                         SEQUENCE LISTING

<110>  Fondazione Centro San Raffaele
       Fondazione Italiana Sclerosi Multipla
 
<120>  PTGDS pathway activators and uses thereof

<130>  PCT123618

<160>  37    

<170>  PatentIn version 3.5

<210>  1
<211>  374
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  synthetic

<400>  1

Lys Thr Lys Lys Gln Arg Gln Lys Leu His Asp Arg Leu Arg Gln Ser 
1               5                   10                  15      


Leu Arg Ser Glu Arg Ser Asn Leu Val Asn Ile Ala Asn Gly Pro His 
            20                  25                  30          


His Pro Asn Pro Pro Pro Glu Asn Val Gln Leu Val Asn Gln Tyr Val 
        35                  40                  45              


Ser Lys Asn Val Ile Ser Ser Glu His Ile Val Glu Arg Glu Val Glu 
    50                  55                  60                  


Thr Ser Phe Ser Thr Ser His Tyr Thr Ser Thr Ala His His Ser Thr 
65                  70                  75                  80  


Thr Val Thr Gln Thr Pro Ser His Ser Trp Ser Asn Gly His Thr Glu 
                85                  90                  95      


Ser Val Ile Ser Glu Ser Asn Ser Val Ile Met Met Ser Ser Val Glu 
            100                 105                 110         


Asn Ser Arg His Ser Ser Pro Ala Gly Gly Pro Arg Gly Arg Leu His 
        115                 120                 125             


Gly Leu Gly Gly Pro Arg Asp Asn Ser Phe Leu Arg His Ala Arg Glu 
    130                 135                 140                 


Thr Pro Asp Ser Tyr Arg Asp Ser Pro His Ser Glu Arg Tyr Val Ser 
145                 150                 155                 160 


Ala Met Thr Thr Pro Ala Arg Met Ser Pro Val Asp Phe His Thr Pro 
                165                 170                 175     


Ser Ser Pro Lys Ser Pro Pro Ser Glu Met Ser Pro Pro Val Ser Ser 
            180                 185                 190         


Met Thr Val Ser Met Pro Ser Val Ala Val Ser Pro Phe Val Glu Glu 
        195                 200                 205             


Glu Arg Pro Leu Leu Leu Val Thr Pro Pro Arg Leu Arg Glu Lys Lys 
    210                 215                 220                 


Tyr Asp His His Pro Gln Gln Leu Asn Ser Phe His His Asn Pro Ala 
225                 230                 235                 240 


His Gln Ser Thr Ser Leu Pro Pro Ser Pro Leu Arg Ile Val Glu Asp 
                245                 250                 255     


Glu Glu Tyr Glu Thr Thr Gln Glu Tyr Glu Ser Val Gln Glu Pro Val 
            260                 265                 270         


Lys Lys Val Thr Asn Ser Arg Arg Ala Lys Arg Thr Lys Pro Asn Gly 
        275                 280                 285             


His Ile Ala Asn Arg Leu Glu Met Asp Ser Asn Thr Ser Ser Val Ser 
    290                 295                 300                 


Ser Asn Ser Glu Ser Glu Thr Glu Asp Glu Arg Val Gly Glu Asp Thr 
305                 310                 315                 320 


Pro Phe Leu Gly Ile Gln Asn Pro Leu Ala Ala Ser Leu Glu Val Ala 
                325                 330                 335     


Pro Ala Phe Arg Leu Ala Glu Ser Arg Thr Asn Pro Ala Gly Arg Phe 
            340                 345                 350         


Ser Thr Gln Glu Glu Leu Gln Ala Arg Leu Ser Ser Val Ile Ala Asn 
        355                 360                 365             


Gln Asp Pro Ile Ala Val 
    370                 


<210>  2
<211>  1125
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  synthetic

<400>  2
aaaaccaaga agcagcggca gaagcttcat gatcggcttc ggcagagtct tcggtcagaa       60

cggagcaacc tggtgaacat agcgaatggg cctcaccacc caaacccacc gccagagaac      120

gtgcagctgg tgaatcaata cgtatctaaa aacgtcatct ccagtgagca tattgttgag      180

agagaagtgg agacttcctt ttccaccagt cattacactt ccacagccca tcactccacg      240

actgtcaccc agactcctag tcacagctgg agtaatgggc acacggagag cgtcatttca      300

gaaagcaact ccgtaatcat gatgtcttcg gtagagaaca gcaggcacag cagtcccgcc      360

gggggcccac gaggacgtct tcatggcctg ggaggccctc gtgataacag cttcctcagg      420

catgccagag aaacccctga ctcctacaga gactctcctc atagcgaaag gtatgtatca      480

gccatgacca ccccggctcg tatgtcacct gtagatttcc acacgccaag ctcccctaaa      540

tcgccccctt cggaaatgtc tccacccgtg tccagcatga cggtgtccat gccctctgtg      600

gcagtcagcc cctttgtgga agaagagagg cctctgctgc ttgtgacgcc accaaggcta      660

cgggagaaga aatatgatca tcacccccag caactcaact cctttcatca caaccctgca      720

catcagagta ccagcctccc ccctagccca ctgaggatag tggaggatga ggagtacgag      780

acgacccagg agtatgagtc agttcaagag cccgttaaga aagtcaccaa tagccggcgg      840

gccaaaagaa ccaagcccaa tggccacatt gccaataggt tggaaatgga cagcaacaca      900

agttctgtga gcagtaactc agaaagtgag acagaagacg aaagagtagg tgaagacaca      960

ccattcctgg gcatacagaa ccccctggca gccagccttg aggtggcccc tgccttccgt     1020

ctggctgaga gcaggactaa cccagcaggc cgcttctcca cacaggagga attacaggcc     1080

aggctgtcta gtgtaatcgc taaccaagac cctattgctg tataa                     1125


<210>  3
<211>  23
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  synthetic

<400>  3
gagttgctgc atctgacctt ttc                                               23


<210>  4
<211>  23
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  synthetic

<400>  4
tagcgaataa tttcggctct tcc                                               23


<210>  5
<211>  21
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  synthetic

<400>  5
tgtcaggaat gtggtatgct c                                                 21


<210>  6
<211>  24
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  synthetic

<400>  6
aatacagctt tcttctcccg gaac                                              24


<210>  7
<211>  28
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  synthetic

<400>  7
atcgccttct atcgccttct tgacgagt                                          28


<210>  8
<211>  30
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  synthetic

<400>  8
atgtgtactg gctccaactt cccagagagt                                        30


<210>  9
<211>  30
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  synthetic

<400>  9
tcttgagagt gcaacagagc aaaggagtcc                                        30


<210>  10
<211>  28
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  synthetic

<400>  10
atcgccttct atcgccttct tgacgagt                                          28


<210>  11
<211>  24
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  synthetic

<400>  11
tggggtcaaa ctcagctcct cacg                                              24


<210>  12
<211>  23
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  synthetic

<400>  12
cgcgcggcta acaagtcgga tag                                               23


<210>  13
<211>  23
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  synthetic

<400>  13
ctcgccggac acgctgaact tgt                                               23


<210>  14
<211>  27
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  synthetic

<400>  14
gagaagaaag agctactgtt tatgtgc                                           27


<210>  15
<211>  26
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  synthetic

<400>  15
ctaaaggtga tgaatttctc cttcag                                            26


<210>  16
<211>  27
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  synthetic

<400>  16
ggttaccagg gctgccttct cttgtga                                           27


<210>  17
<211>  25
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  synthetic

<400>  17
cggaaggggc ggagatgatg accct                                             25


<210>  18
<211>  24
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  synthetic

<400>  18
cttgagggag ttgtcatatt tctc                                              24


<210>  19
<211>  26
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  synthetic

<400>  19
acctcaacta catggtctac atgttc                                            26


<210>  20
<211>  26
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  synthetic

<400>  20
atcttgaggg agttgtcata tttctc                                            26


<210>  21
<211>  24
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  synthetic

<400>  21
cattctcggt aataggcttc tctg                                              24


<210>  22
<211>  24
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  synthetic

<400>  22
tccacaagtt taaaggctcc atag                                              24


<210>  23
<211>  25
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  synthetic

<400>  23
cactactcta tgtgctcact tgtcc                                             25


<210>  24
<211>  25
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  synthetic

<400>  24
ccatctaatc caaagtacag ctcaa                                             25


<210>  25
<211>  24
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  synthetic

<400>  25
ctgtcggatc cacaaaaaga gtag                                              24


<210>  26
<211>  25
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  synthetic

<400>  26
gaattcatgt cgtagatgac aaatg                                             25


<210>  27
<211>  25
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  synthetic

<400>  27
aacaaccaaa tcagagaaaa tgcag                                             25


<210>  28
<211>  26
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  synthetic

<400>  28
agcaaaccat accttagtga aacctc                                            26


<210>  29
<211>  27
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  synthetic

<400>  29
caggtctact ttttatgtct ccaatgg                                           27


<210>  30
<211>  25
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  synthetic

<400>  30
atccgtaggc cagatctata agacg                                             25


<210>  31
<211>  23
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  synthetic

<400>  31
ttcttgttct gcaacctgct act                                               23


<210>  32
<211>  22
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  synthetic

<400>  32
attgaaggag gcctcaagtc tg                                                22


<210>  33
<211>  22
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  synthetic

<400>  33
attgaaggag gcctcaagtc tg                                                22


<210>  34
<211>  24
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  synthetic

<400>  34
tctcacaccc cttcaccaaa gacc                                              24


<210>  35
<211>  26
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  synthetic

<400>  35
aaatagcagt gatccgagaa tactcc                                            26


<210>  36
<211>  26
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  synthetic

<400>  36
ggtctacatg ttccagtatg actcta                                            26


<210>  37
<211>  24
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  synthetic

<400>  37
cttgagggag ttgtcatatt tctc                                              24


