                         SEQUENCE LISTING

<110>  Charit - Universittsmedizin Berlin
 
<120>  IMMORTALISIERTE HUMANE CHORIONZELLLINIE SOWIE VERFAHREN ZUR 
       IMMORTALISIERUNG HUMANER CHORIONZELLEN

<130>  XI 403/13WO

<160>  6     

<170>  PatentIn version 3.5

<210>  1
<211>  3073
<212>  DNA
<213>  Homo sapiens

<400>  1
ttttattatt atagtcagct gacgtgtagt gtatttatac ccggtgagtt cctcaagagg       60

ccactcttga gtgccagcga gtagagtttt ctcctccgag ccgctccgac accgggactg      120

aaaatgagac atattatctg ccacggaggt gttattaccg aagaaatggc cgccagtctt      180

ttggaccagc tgatcgaaga ggtactggct gataatcttc cacctcctag ccattttgaa      240

ccacctaccc ttcacgaact gtatgattta gacgtgacgg cccccgaaga tcccaacgag      300

gaggcggttt cgcagatttt tcccgactct gtaatgttgg cggtgcagga agggattgac      360

ttactcactt ttccgccggc gcccggttct ccggagccgc ctcacctttc ccggcagccc      420

gagcagccgg agcagagagc cttgggtccg gtttctatgc caaaccttgt accggaggtg      480

atcgatctta cctgccacga ggctggcttt ccacccagtg acgacgagga tgaagagggt      540

gaggagtttg tgttagatta tgtggagcac cccgggcacg gttgcaggtc ttgtcattat      600

caccggagga atacggggga cccagatatt atgtgttcgc tttgctatat gaggacctgt      660

ggcatgtttg tctacagtaa gtgaaaatta tgggcagtgg gtgatagagt ggtgggtttg      720

gtgtggtaat ttttttttta atttttacag ttttgtggtt taaagaattt tgtattgtga      780

tttttttaaa aggtcctgtg tctgaacctg agcctgagcc cgagccagaa ccggagcctg      840

caagacctac ccgccgtcct aaaatggcgc ctgctatcct gagacgcccg acatcacctg      900

tgtctagaga atgcaatagt agtacggata gctgtgactc cggtccttct aacacacctc      960

ctgagataca cccggtggtc ccgctgtgcc ccattaaacc agttgccgtg agagttggtg     1020

ggcgtcgcca ggctgtggaa tgtatcgagg acttgcttaa cgagcctggg caacctttgg     1080

acttgagctg taaacgcccc aggccataag gtgtaaacct gtgattgcgt gtgtggttaa     1140

cgcctttgtt tgctgaatga gttgatgtaa gtttaataaa gggtgagata atgtttaact     1200

tgcatggcgt gttaaatggg gcggggctta aagggtatat aatgcgccgt gggctaatct     1260

tggttacatc tgacctcatg gaggcttggg agtgtttgga agatttttct gctgtgcgta     1320

acttgctgga acagagctct aacagtacct cttggttttg gaggtttctg tggggctcat     1380

cccaggcaaa gttagtctgc agaattaagg aggattacaa gtgggaattt gaagagcttt     1440

tgaaatcctg tggtgagctg tttgattctt tgaatctggg tcaccaggcg cttttccaag     1500

agaaggtcat caagactttg gatttttcca caccggggcg cgctgcggct gctgttgctt     1560

ttttgagttt tataaaggat aaatggagcg aagaaaccca tctgagcggg gggtacctgc     1620

tggattttct ggccatgcat ctgtggagag cggttgtgag acacaagaat cgcctgctac     1680

tgttgtcttc cgtccgcccg gcgataatac cgacggagga gcagcagcag cagcaggagg     1740

aagccaggcg gcggcggcag gagcagagcc catggaaccc gagagccggc ctggaccctc     1800

gggaatgaat gttgtacagg tggctgaact gtatccagaa ctgagacgca ttttgacaat     1860

tacagaggat gggcaggggc taaagggggt aaagagggag cggggggctt gtgaggctac     1920

agaggaggct aggaatctag cttttagctt aatgaccaga caccgtcctg agtgtattac     1980

ttttcaacag atcaaggata attgcgctaa tgagcttgat ctgctggcgc agaagtattc     2040

catagagcag ctgaccactt actggctgca gccaggggat gattttgagg aggctattag     2100

ggtatatgca aaggtggcac ttaggccaga ttgcaagtac aagatcagca aacttgtaaa     2160

tatcaggaat tgttgctaca tttctgggaa cggggccgag gtggagatag atacggagga     2220

tagggtggcc tttagatgta gcatgataaa tatgtggccg ggggtgcttg gcatggacgg     2280

ggtggttatt atgaatgtaa ggtttactgg ccccaatttt agcggtacgg ttttcctggc     2340

caataccaac cttatcctac acggtgtaag cttctatggg tttaacaata cctgtgtgga     2400

agcctggacc gatgtaaggg ttcggggctg tgccttttac tgctgctgga agggggtggt     2460

gtgtcgcccc aaaagcaggg cttcaattaa gaaatgcctc tttgaaaggt gtaccttggg     2520

tatcctgtct gagggtaact ccagggtgcg ccacaatgtg gcctccgact gtggttgctt     2580

catgctagtg aaaagcgtgg ctgtgattaa gcataacatg gtatgtggca actgcgagga     2640

cagggcctct cagatgctga cctgctcgga cggcaactgt cacctgctga agaccattca     2700

cgtagccagc cactctcgca aggcctggcc agtgtttgag cataacatac tgacccgctg     2760

ttccttgcat ttgggtaaca ggaggggggt gttcctacct taccaatgca atttgagtca     2820

cactaagata ttgcttgagc ccgagagcat gtccaaggtg aacctgaacg gggtgtttga     2880

catgaccatg aagatctgga aggtgctgag gtacgatgag acccgcacca ggtgcagacc     2940

ctgcgagtgt ggcggtaaac atattaggaa ccagcctgtg atgctggatg tgaccgagga     3000

gctgaggccc gatcacttgg tgctggcctg cacccgcgct gagtttggct ctagcgatga     3060

agatacagat tga                                                        3073


<210>  2
<211>  289
<212>  PRT
<213>  Homo sapiens

<400>  2

Met Arg His Ile Ile Cys His Gly Gly Val Ile Thr Glu Glu Met Ala 
1               5                   10                  15      


Ala Ser Leu Leu Asp Gln Leu Ile Glu Glu Val Leu Ala Asp Asn Leu 
            20                  25                  30          


Pro Pro Pro Ser His Phe Glu Pro Pro Thr Leu His Glu Leu Tyr Asp 
        35                  40                  45              


Leu Asp Val Thr Ala Pro Glu Asp Pro Asn Glu Glu Ala Val Ser Gln 
    50                  55                  60                  


Ile Phe Pro Asp Ser Val Met Leu Ala Val Gln Glu Gly Ile Asp Leu 
65                  70                  75                  80  


Leu Thr Phe Pro Pro Ala Pro Gly Ser Pro Glu Pro Pro His Leu Ser 
                85                  90                  95      


Arg Gln Pro Glu Gln Pro Glu Gln Arg Ala Leu Gly Pro Val Ser Met 
            100                 105                 110         


Pro Asn Leu Val Pro Glu Val Ile Asp Leu Thr Cys His Glu Ala Gly 
        115                 120                 125             


Phe Pro Pro Ser Asp Asp Glu Asp Glu Glu Gly Glu Glu Phe Val Leu 
    130                 135                 140                 


Asp Tyr Val Glu His Pro Gly His Gly Cys Arg Ser Cys His Tyr His 
145                 150                 155                 160 


Arg Arg Asn Thr Gly Asp Pro Asp Ile Met Cys Ser Leu Cys Tyr Met 
                165                 170                 175     


Arg Thr Cys Gly Met Phe Val Tyr Ser Pro Val Ser Glu Pro Glu Pro 
            180                 185                 190         


Glu Pro Glu Pro Glu Pro Glu Pro Ala Arg Pro Thr Arg Arg Pro Lys 
        195                 200                 205             


Met Ala Pro Ala Ile Leu Arg Arg Pro Thr Ser Pro Val Ser Arg Glu 
    210                 215                 220                 


Cys Asn Ser Ser Thr Asp Ser Cys Asp Ser Gly Pro Ser Asn Thr Pro 
225                 230                 235                 240 


Pro Glu Ile His Pro Val Val Pro Leu Cys Pro Ile Lys Pro Val Ala 
                245                 250                 255     


Val Arg Val Gly Gly Arg Arg Gln Ala Val Glu Cys Ile Glu Asp Leu 
            260                 265                 270         


Leu Asn Glu Pro Gly Gln Pro Leu Asp Leu Ser Cys Lys Arg Pro Arg 
        275                 280                 285             


Pro 
    


<210>  3
<211>  176
<212>  PRT
<213>  Homo sapiens

<400>  3

Met Glu Ala Trp Glu Cys Leu Glu Asp Phe Ser Ala Val Arg Asn Leu 
1               5                   10                  15      


Leu Glu Gln Ser Ser Asn Ser Thr Ser Trp Phe Trp Arg Phe Leu Trp 
            20                  25                  30          


Gly Ser Ser Gln Ala Lys Leu Val Cys Arg Ile Lys Glu Asp Tyr Lys 
        35                  40                  45              


Trp Glu Phe Glu Glu Leu Leu Lys Ser Cys Gly Glu Leu Phe Asp Ser 
    50                  55                  60                  


Leu Asn Leu Gly His Gln Ala Leu Phe Gln Glu Lys Val Ile Lys Thr 
65                  70                  75                  80  


Leu Asp Phe Ser Thr Pro Gly Arg Ala Ala Ala Ala Val Ala Phe Leu 
                85                  90                  95      


Ser Phe Ile Lys Asp Lys Trp Ser Glu Glu Thr His Leu Ser Gly Gly 
            100                 105                 110         


Tyr Leu Leu Asp Phe Leu Ala Met His Leu Trp Arg Ala Val Val Arg 
        115                 120                 125             


His Lys Asn Arg Leu Leu Leu Leu Ser Ser Val Arg Pro Ala Ile Ile 
    130                 135                 140                 


Pro Thr Glu Glu Gln Gln Gln Gln Gln Glu Glu Ala Arg Arg Arg Arg 
145                 150                 155                 160 


Gln Glu Gln Ser Pro Trp Asn Pro Arg Ala Gly Leu Asp Pro Arg Glu 
                165                 170                 175     


<210>  4
<211>  496
<212>  PRT
<213>  Homo sapiens

<400>  4

Met Glu Arg Arg Asn Pro Ser Glu Arg Gly Val Pro Ala Gly Phe Ser 
1               5                   10                  15      


Gly His Ala Ser Val Glu Ser Gly Cys Glu Thr Gln Glu Ser Pro Ala 
            20                  25                  30          


Thr Val Val Phe Arg Pro Pro Gly Asp Asn Thr Asp Gly Gly Ala Ala 
        35                  40                  45              


Ala Ala Ala Gly Gly Ser Gln Ala Ala Ala Ala Gly Ala Glu Pro Met 
    50                  55                  60                  


Glu Pro Glu Ser Arg Pro Gly Pro Ser Gly Met Asn Val Val Gln Val 
65                  70                  75                  80  


Ala Glu Leu Tyr Pro Glu Leu Arg Arg Ile Leu Thr Ile Thr Glu Asp 
                85                  90                  95      


Gly Gln Gly Leu Lys Gly Val Lys Arg Glu Arg Gly Ala Cys Glu Ala 
            100                 105                 110         


Thr Glu Glu Ala Arg Asn Leu Ala Phe Ser Leu Met Thr Arg His Arg 
        115                 120                 125             


Pro Glu Cys Ile Thr Phe Gln Gln Ile Lys Asp Asn Cys Ala Asn Glu 
    130                 135                 140                 


Leu Asp Leu Leu Ala Gln Lys Tyr Ser Ile Glu Gln Leu Thr Thr Tyr 
145                 150                 155                 160 


Trp Leu Gln Pro Gly Asp Asp Phe Glu Glu Ala Ile Arg Val Tyr Ala 
                165                 170                 175     


Lys Val Ala Leu Arg Pro Asp Cys Lys Tyr Lys Ile Ser Lys Leu Val 
            180                 185                 190         


Asn Ile Arg Asn Cys Cys Tyr Ile Ser Gly Asn Gly Ala Glu Val Glu 
        195                 200                 205             


Ile Asp Thr Glu Asp Arg Val Ala Phe Arg Cys Ser Met Ile Asn Met 
    210                 215                 220                 


Trp Pro Gly Val Leu Gly Met Asp Gly Val Val Ile Met Asn Val Arg 
225                 230                 235                 240 


Phe Thr Gly Pro Asn Phe Ser Gly Thr Val Phe Leu Ala Asn Thr Asn 
                245                 250                 255     


Leu Ile Leu His Gly Val Ser Phe Tyr Gly Phe Asn Asn Thr Cys Val 
            260                 265                 270         


Glu Ala Trp Thr Asp Val Arg Val Arg Gly Cys Ala Phe Tyr Cys Cys 
        275                 280                 285             


Trp Lys Gly Val Val Cys Arg Pro Lys Ser Arg Ala Ser Ile Lys Lys 
    290                 295                 300                 


Cys Leu Phe Glu Arg Cys Thr Leu Gly Ile Leu Ser Glu Gly Asn Ser 
305                 310                 315                 320 


Arg Val Arg His Asn Val Ala Ser Asp Cys Gly Cys Phe Met Leu Val 
                325                 330                 335     


Lys Ser Val Ala Val Ile Lys His Asn Met Val Cys Gly Asn Cys Glu 
            340                 345                 350         


Asp Arg Ala Ser Gln Met Leu Thr Cys Ser Asp Gly Asn Cys His Leu 
        355                 360                 365             


Leu Lys Thr Ile His Val Ala Ser His Ser Arg Lys Ala Trp Pro Val 
    370                 375                 380                 


Phe Glu His Asn Ile Leu Thr Arg Cys Ser Leu His Leu Gly Asn Arg 
385                 390                 395                 400 


Arg Gly Val Phe Leu Pro Tyr Gln Cys Asn Leu Ser His Thr Lys Ile 
                405                 410                 415     


Leu Leu Glu Pro Glu Ser Met Ser Lys Val Asn Leu Asn Gly Val Phe 
            420                 425                 430         


Asp Met Thr Met Lys Ile Trp Lys Val Leu Arg Tyr Asp Glu Thr Arg 
        435                 440                 445             


Thr Arg Cys Arg Pro Cys Glu Cys Gly Gly Lys His Ile Arg Asn Gln 
    450                 455                 460                 


Pro Val Met Leu Asp Val Thr Glu Glu Leu Arg Pro Asp His Leu Val 
465                 470                 475                 480 


Leu Ala Cys Thr Arg Ala Glu Phe Gly Ser Ser Asp Glu Asp Thr Asp 
                485                 490                 495     


<210>  5
<211>  3210
<212>  DNA
<213>  Homo sapiens

<400>  5
atgccgcgcg ctccccgctg ccgagccgtg cgctccctgc tgcgcagcca ctaccgcgag       60

gtgctgccgc tggccacgtt cgtgcggcgc ctggggcccc agggctggcg gctggtgcag      120

cgcggggacc cggcggcttt ccgcgcgctg gtggcccagt gcctggtgtg cgtgccctgg      180

gacgcacggc cgccccccgc cgccccctcc ttccgccagg tgtcctgcct gaaggagctg      240

gtggcccgag tgctgcagag gctgtgcgag cgcggcgcga agaacgtgct ggccttcggc      300

ttcgcgctgc tggacggggc ccgcgggggc ccccccgagg ccttcaccac cagcgtgcgc      360

agctacctgc ccaacacggt gaccgacgca ctgcggggga gcggggcgtg ggggctgctg      420

ctgcgccgcg tgggcgacga cgtgctggtt cacctgctgg cacgctgcgc gctctttgtg      480

ctggtggctc ccagctgcgc ctaccaggtg tgcgggccgc cgctgtacca gctcggcgct      540

gccactcagg cccggccccc gccacacgct agtggacccc gaaggcgtct gggatgcgaa      600

cgggcctgga accatagcgt cagggaggcc ggggtccccc tgggcctgcc agccccgggt      660

gcgaggaggc gcgggggcag tgccagccga agtctgccgt tgcccaagag gcccaggcgt      720

ggcgctgccc ctgagccgga gcggacgccc gttgggcagg ggtcctgggc ccacccgggc      780

aggacgcgtg gaccgagtga ccgtggtttc tgtgtggtgt cacctgccag acccgccgaa      840

gaagccacct ctttggaggg tgcgctctct ggcacgcgcc actcccaccc atccgtgggc      900

cgccagcacc acgcgggccc cccatccaca tcgcggccac cacgtccctg ggacacgcct      960

tgtcccccgg tgtacgccga gaccaagcac ttcctctact cctcaggcga caaggagcag     1020

ctgcggccct ccttcctact cagctctctg aggcccagcc tgactggcgc tcggaggctc     1080

gtggagacca tctttctggg ttccaggccc tggatgccag ggactccccg caggttgccc     1140

cgcctgcccc agcgctactg gcaaatgcgg cccctgtttc tggagctgct tgggaaccac     1200

gcgcagtgcc cctacggggt gctcctcaag acgcactgcc cgctgcgagc tgcggtcacc     1260

ccagcagccg gtgtctgtgc ccgggagaag ccccagggct ctgtggcggc ccccgaggag     1320

gaggacacag acccccgtcg cctggtgcag ctgctccgcc agcacagcag cccctggcag     1380

gtgtacggct tcgtgcgggc ctgcctgcgc cggctggtgc ccccaggcct ctggggctcc     1440

aggcacaacg aacgccgctt cctcaggaac accaagaagt tcatctccct ggggaagcat     1500

gccaagctct cgctgcagga gctgacgtgg aagatgagcg tgcgggactg cgcttggctg     1560

cgcaggagcc caggggttgg ctgtgttccg gccgcagagc accgtctgcg tgaggagatc     1620

ctggccaagt tcctgcactg gctgatgagt gtgtacgtcg tcgagctgct caggtctttc     1680

ttttatgtca cggagaccac gtttcaaaag aacaggctct ttttctaccg gaagagtgtc     1740

tggagcaagt tgcaaagcat tggaatcaga cagcacttga agagggtgca gctgcgggag     1800

ctgtcggaag cagaggtcag gcagcatcgg gaagccaggc ccgccctgct gacgtccaga     1860

ctccgcttca tccccaagcc tgacgggctg cggccgattg tgaacatgga ctacgtcgtg     1920

ggagccagaa cgttccgcag agaaaagagg gccgagcgtc tcacctcgag ggtgaaggca     1980

ctgttcagcg tgctcaacta cgagcgggcg cggcgccccg gcctcctggg cgcctctgtg     2040

ctgggcctgg acgatatcca cagggcctgg cgcaccttcg tgctgcgtgt gcgggcccag     2100

gacccgccgc ctgagctgta ctttgtcaag gtggatgtga cgggcgcgta cgacaccatc     2160

ccccaggaca ggctcacgga ggtcatcgcc agcatcatca aaccccagaa cacgtactgc     2220

gtgcgtcggt atgccgtggt ccagaaggcc gcccatgggc acgtccgcaa ggccttcaag     2280

agccacgtct ctaccttgac agacctccag ccgtacatgc gacagttcgt ggctcacctg     2340

caggagacca gcccgctgag ggatgccgtc gtcatcgagc agagctcctc cctgaatgag     2400

gccagcagtg gcctcttcga cgtcttccta cgcttcatgt gccaccacgc cgtgcgcatc     2460

aggggcaagt cctacgtcca gtgccagggg atcccgcagg gctccatcct ctccacgctg     2520

ctctgcagcc tgtgctacgg cgacatggag aacaagctgt ttgcggggat tcggcgggac     2580

gggctgctcc tgcgtttggt ggatgatttc ttgttggtga cacctcacct cacccacgcg     2640

aaaaccttcc tcagctatgc ccggacctcc atcagagcca gtctcacctt caaccgcggc     2700

ttcaaggctg ggaggaacat gcgtcgcaaa ctctttgggg tcttgcggct gaagtgtcac     2760

agcctgtttc tggatttgca ggtgaacagc ctccagacgg tgtgcaccaa catctacaag     2820

atcctcctgc tgcaggcgta caggtttcac gcatgtgtgc tgcagctccc atttcatcag     2880

caagtttgga agaaccccac atttttcctg cgcgtcatct ctgacacggc ctccctctgc     2940

tactccatcc tgaaagccaa gaacgcaggg atgtcgctgg gggccaaggg cgccgccggc     3000

cctctgccct ccgaggccgt gcagtggctg tgccaccaag cattcctgct caagctgact     3060

cgacaccgtg tcacctacgt gccactcctg gggtcactca ggacagccca gacgcagctg     3120

agtcggaagc tcccggggac gacgctgact gccctggagg ccgcagccaa cccggcactg     3180

ccctcagact tcaagaccat cctggactga                                      3210


<210>  6
<211>  1069
<212>  PRT
<213>  Homo sapiens

<400>  6

Met Pro Arg Ala Pro Arg Cys Arg Ala Val Arg Ser Leu Leu Arg Ser 
1               5                   10                  15      


His Tyr Arg Glu Val Leu Pro Leu Ala Thr Phe Val Arg Arg Leu Gly 
            20                  25                  30          


Pro Gln Gly Trp Arg Leu Val Gln Arg Gly Asp Pro Ala Ala Phe Arg 
        35                  40                  45              


Ala Leu Val Ala Gln Cys Leu Val Cys Val Pro Trp Asp Ala Arg Pro 
    50                  55                  60                  


Pro Pro Ala Ala Pro Ser Phe Arg Gln Val Ser Cys Leu Lys Glu Leu 
65                  70                  75                  80  


Val Ala Arg Val Leu Gln Arg Leu Cys Glu Arg Gly Ala Lys Asn Val 
                85                  90                  95      


Leu Ala Phe Gly Phe Ala Leu Leu Asp Gly Ala Arg Gly Gly Pro Pro 
            100                 105                 110         


Glu Ala Phe Thr Thr Ser Val Arg Ser Tyr Leu Pro Asn Thr Val Thr 
        115                 120                 125             


Asp Ala Leu Arg Gly Ser Gly Ala Trp Gly Leu Leu Leu Arg Arg Val 
    130                 135                 140                 


Gly Asp Asp Val Leu Val His Leu Leu Ala Arg Cys Ala Leu Phe Val 
145                 150                 155                 160 


Leu Val Ala Pro Ser Cys Ala Tyr Gln Val Cys Gly Pro Pro Leu Tyr 
                165                 170                 175     


Gln Leu Gly Ala Ala Thr Gln Ala Arg Pro Pro Pro His Ala Ser Gly 
            180                 185                 190         


Pro Arg Arg Arg Leu Gly Cys Glu Arg Ala Trp Asn His Ser Val Arg 
        195                 200                 205             


Glu Ala Gly Val Pro Leu Gly Leu Pro Ala Pro Gly Ala Arg Arg Arg 
    210                 215                 220                 


Gly Gly Ser Ala Ser Arg Ser Leu Pro Leu Pro Lys Arg Pro Arg Arg 
225                 230                 235                 240 


Gly Ala Ala Pro Glu Pro Glu Arg Thr Pro Val Gly Gln Gly Ser Trp 
                245                 250                 255     


Ala His Pro Gly Arg Thr Arg Gly Pro Ser Asp Arg Gly Phe Cys Val 
            260                 265                 270         


Val Ser Pro Ala Arg Pro Ala Glu Glu Ala Thr Ser Leu Glu Gly Ala 
        275                 280                 285             


Leu Ser Gly Thr Arg His Ser His Pro Ser Val Gly Arg Gln His His 
    290                 295                 300                 


Ala Gly Pro Pro Ser Thr Ser Arg Pro Pro Arg Pro Trp Asp Thr Pro 
305                 310                 315                 320 


Cys Pro Pro Val Tyr Ala Glu Thr Lys His Phe Leu Tyr Ser Ser Gly 
                325                 330                 335     


Asp Lys Glu Gln Leu Arg Pro Ser Phe Leu Leu Ser Ser Leu Arg Pro 
            340                 345                 350         


Ser Leu Thr Gly Ala Arg Arg Leu Val Glu Thr Ile Phe Leu Gly Ser 
        355                 360                 365             


Arg Pro Trp Met Pro Gly Thr Pro Arg Arg Leu Pro Arg Leu Pro Gln 
    370                 375                 380                 


Arg Tyr Trp Gln Met Arg Pro Leu Phe Leu Glu Leu Leu Gly Asn His 
385                 390                 395                 400 


Ala Gln Cys Pro Tyr Gly Val Leu Leu Lys Thr His Cys Pro Leu Arg 
                405                 410                 415     


Ala Ala Val Thr Pro Ala Ala Gly Val Cys Ala Arg Glu Lys Pro Gln 
            420                 425                 430         


Gly Ser Val Ala Ala Pro Glu Glu Glu Asp Thr Asp Pro Arg Arg Leu 
        435                 440                 445             


Val Gln Leu Leu Arg Gln His Ser Ser Pro Trp Gln Val Tyr Gly Phe 
    450                 455                 460                 


Val Arg Ala Cys Leu Arg Arg Leu Val Pro Pro Gly Leu Trp Gly Ser 
465                 470                 475                 480 


Arg His Asn Glu Arg Arg Phe Leu Arg Asn Thr Lys Lys Phe Ile Ser 
                485                 490                 495     


Leu Gly Lys His Ala Lys Leu Ser Leu Gln Glu Leu Thr Trp Lys Met 
            500                 505                 510         


Ser Val Arg Asp Cys Ala Trp Leu Arg Arg Ser Pro Gly Val Gly Cys 
        515                 520                 525             


Val Pro Ala Ala Glu His Arg Leu Arg Glu Glu Ile Leu Ala Lys Phe 
    530                 535                 540                 


Leu His Trp Leu Met Ser Val Tyr Val Val Glu Leu Leu Arg Ser Phe 
545                 550                 555                 560 


Phe Tyr Val Thr Glu Thr Thr Phe Gln Lys Asn Arg Leu Phe Phe Tyr 
                565                 570                 575     


Arg Lys Ser Val Trp Ser Lys Leu Gln Ser Ile Gly Ile Arg Gln His 
            580                 585                 590         


Leu Lys Arg Val Gln Leu Arg Glu Leu Ser Glu Ala Glu Val Arg Gln 
        595                 600                 605             


His Arg Glu Ala Arg Pro Ala Leu Leu Thr Ser Arg Leu Arg Phe Ile 
    610                 615                 620                 


Pro Lys Pro Asp Gly Leu Arg Pro Ile Val Asn Met Asp Tyr Val Val 
625                 630                 635                 640 


Gly Ala Arg Thr Phe Arg Arg Glu Lys Arg Ala Glu Arg Leu Thr Ser 
                645                 650                 655     


Arg Val Lys Ala Leu Phe Ser Val Leu Asn Tyr Glu Arg Ala Arg Arg 
            660                 665                 670         


Pro Gly Leu Leu Gly Ala Ser Val Leu Gly Leu Asp Asp Ile His Arg 
        675                 680                 685             


Ala Trp Arg Thr Phe Val Leu Arg Val Arg Ala Gln Asp Pro Pro Pro 
    690                 695                 700                 


Glu Leu Tyr Phe Val Lys Val Asp Val Thr Gly Ala Tyr Asp Thr Ile 
705                 710                 715                 720 


Pro Gln Asp Arg Leu Thr Glu Val Ile Ala Ser Ile Ile Lys Pro Gln 
                725                 730                 735     


Asn Thr Tyr Cys Val Arg Arg Tyr Ala Val Val Gln Lys Ala Ala His 
            740                 745                 750         


Gly His Val Arg Lys Ala Phe Lys Ser His Val Ser Thr Leu Thr Asp 
        755                 760                 765             


Leu Gln Pro Tyr Met Arg Gln Phe Val Ala His Leu Gln Glu Thr Ser 
    770                 775                 780                 


Pro Leu Arg Asp Ala Val Val Ile Glu Gln Ser Ser Ser Leu Asn Glu 
785                 790                 795                 800 


Ala Ser Ser Gly Leu Phe Asp Val Phe Leu Arg Phe Met Cys His His 
                805                 810                 815     


Ala Val Arg Ile Arg Gly Lys Ser Tyr Val Gln Cys Gln Gly Ile Pro 
            820                 825                 830         


Gln Gly Ser Ile Leu Ser Thr Leu Leu Cys Ser Leu Cys Tyr Gly Asp 
        835                 840                 845             


Met Glu Asn Lys Leu Phe Ala Gly Ile Arg Arg Asp Gly Leu Leu Leu 
    850                 855                 860                 


Arg Leu Val Asp Asp Phe Leu Leu Val Thr Pro His Leu Thr His Ala 
865                 870                 875                 880 


Lys Thr Phe Leu Ser Tyr Ala Arg Thr Ser Ile Arg Ala Ser Leu Thr 
                885                 890                 895     


Phe Asn Arg Gly Phe Lys Ala Gly Arg Asn Met Arg Arg Lys Leu Phe 
            900                 905                 910         


Gly Val Leu Arg Leu Lys Cys His Ser Leu Phe Leu Asp Leu Gln Val 
        915                 920                 925             


Asn Ser Leu Gln Thr Val Cys Thr Asn Ile Tyr Lys Ile Leu Leu Leu 
    930                 935                 940                 


Gln Ala Tyr Arg Phe His Ala Cys Val Leu Gln Leu Pro Phe His Gln 
945                 950                 955                 960 


Gln Val Trp Lys Asn Pro Thr Phe Phe Leu Arg Val Ile Ser Asp Thr 
                965                 970                 975     


Ala Ser Leu Cys Tyr Ser Ile Leu Lys Ala Lys Asn Ala Gly Met Ser 
            980                 985                 990         


Leu Gly Ala Lys Gly Ala Ala Gly  Pro Leu Pro Ser Glu  Ala Val Gln 
        995                 1000                 1005             


Trp Leu  Cys His Gln Ala Phe  Leu Leu Lys Leu Thr  Arg His Arg 
    1010                 1015                 1020             


Val Thr  Tyr Val Pro Leu Leu  Gly Ser Leu Arg Thr  Ala Gln Thr 
    1025                 1030                 1035             


Gln Leu  Ser Arg Lys Leu Pro  Gly Thr Thr Leu Thr  Ala Leu Glu 
    1040                 1045                 1050             


Ala Ala  Ala Asn Pro Ala Leu  Pro Ser Asp Phe Lys  Thr Ile Leu 
    1055                 1060                 1065             


Asp 
    


