                         SEQUENCE LISTING

<110>  Gellman, Samuel H.
       Cheloha, Ross W.
       Gardella, Thomas J.
 
<120>  ALPHA-/BETA-POLYPEPTIDE ANALOGS OF PARATHYROID HORMONE (PTH) AND 
       METHOD OF USING SAME

<130>  09820.579

<140>  xx/yyy,zzz
<141>  2014-06-23

<150>  61/940,124
<151>  2014-02-14

<150>  61/838,307
<151>  2013-06-23

<160>  60    

<170>  PatentIn version 3.5

<210>  1
<211>  34
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificial PTH polypeptide.

<400>  1

Ser Val Ser Glu Ile Gln Leu Met His Asn Leu Gly Lys His Leu Asn 
1               5                   10                  15      


Ser Met Glu Arg Val Glu Trp Leu Arg Lys Lys Leu Gln Asp Val His 
            20                  25                  30          


Asn Phe 
        


<210>  2
<211>  34
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificial PTH polypeptide.

<400>  2

Ser Val Ser Glu Ile Gln Leu Met His Asn Leu Gly Lys His Leu Asn 
1               5                   10                  15      


Ser Met Glu Arg Val Glu Trp Leu Arg Lys Lys Leu Gln Asp Val Gln 
            20                  25                  30          


Asn Phe 
        


<210>  3
<211>  34
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificial PTH polypeptide.

<400>  3

Ser Val Ser Glu Ile Gln Leu Met His Asn Leu Gly Lys His Leu Asn 
1               5                   10                  15      


Ser Met Glu Arg Val Glu Trp Leu Arg Lys Lys Leu Gln Asp Val His 
            20                  25                  30          


Asn Phe 
        


<210>  4
<211>  34
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificial PTH polypeptide.

<400>  4

Ser Val Ser Glu Ile Gln Leu Met His Asn Leu Gly Lys His Leu Asn 
1               5                   10                  15      


Ser Met Glu Arg Val Glu Trp Leu Arg Lys Lys Leu Gln Asp Val His 
            20                  25                  30          


Asn Phe 
        


<210>  5
<211>  34
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificial PTH polypeptide.

<400>  5

Ser Val Ser Glu Ile Gln Leu Met His Asn Leu Gly Lys His Leu Asn 
1               5                   10                  15      


Ser Met Glu Arg Val Glu Trp Leu Arg Lys Lys Leu Gln Asp Val His 
            20                  25                  30          


Asn Phe 
        


<210>  6
<211>  34
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificial PTH polypeptide.

<400>  6

Ser Val Ser Glu Ile Gln Leu Met His Asn Leu Gly Lys His Leu Asn 
1               5                   10                  15      


Ser Met Glu Arg Val Glu Trp Leu Arg Lys Lys Leu Gln Asp Val Gln 
            20                  25                  30          


Asn Phe 
        


<210>  7
<211>  34
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificial PTH polypeptide.

<400>  7

Ser Val Ser Glu Ile Gln Leu Met His Asn Leu Gly Lys His Leu Asn 
1               5                   10                  15      


Ser Met Glu Arg Val Glu Trp Leu Arg Lys Lys Leu Gln Asp Val His 
            20                  25                  30          


Asn Phe 
        


<210>  8
<211>  34
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificial PTH polypeptide.

<400>  8

Ser Val Ser Glu Ile Gln Leu Met His Asn Leu Gly Lys His Leu Asn 
1               5                   10                  15      


Ser Met Glu Arg Val Glu Trp Leu Arg Lys Lys Leu Gln Asp Val His 
            20                  25                  30          


Asn Phe 
        


<210>  9
<211>  34
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificial PTH polypeptide.

<400>  9

Ser Val Ser Glu Ile Gln Leu Met His Asn Leu Gly Lys Trp Leu Asn 
1               5                   10                  15      


Ser Met Glu Arg Val Glu Trp Leu Arg Lys Lys Leu Gln Asp Val His 
            20                  25                  30          


Asn Phe 
        


<210>  10
<211>  34
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificial PTH polypeptide.

<400>  10

Ser Val Ser Glu Ile Gln Leu Met His Asn Leu Gly Lys Trp Leu Asn 
1               5                   10                  15      


Ser Met Glu Arg Val Glu Trp Leu Arg Lys Lys Leu Gln Asp Val His 
            20                  25                  30          


Asn Phe 
        


<210>  11
<211>  115
<212>  PRT
<213>  Homo sapiens

<400>  11

Met Ile Pro Ala Lys Asp Met Ala Lys Val Met Ile Val Met Leu Ala 
1               5                   10                  15      


Ile Cys Phe Leu Thr Lys Ser Asp Gly Lys Ser Val Lys Lys Arg Ser 
            20                  25                  30          


Val Ser Glu Ile Gln Leu Met His Asn Leu Gly Lys His Leu Asn Ser 
        35                  40                  45              


Met Glu Arg Val Glu Trp Leu Arg Lys Lys Leu Gln Asp Val His Asn 
    50                  55                  60                  


Phe Val Ala Leu Gly Ala Pro Leu Ala Pro Arg Asp Ala Gly Ser Gln 
65                  70                  75                  80  


Arg Pro Arg Lys Lys Glu Asp Asn Val Leu Val Glu Ser His Glu Lys 
                85                  90                  95      


Ser Leu Gly Glu Ala Asp Lys Ala Asp Val Asn Val Leu Thr Lys Ala 
            100                 105                 110         


Lys Ser Gln 
        115 


<210>  12
<211>  84
<212>  PRT
<213>  Homo sapiens

<400>  12

Ser Val Ser Glu Ile Gln Leu Met His Asn Leu Gly Lys His Leu Asn 
1               5                   10                  15      


Ser Met Glu Arg Val Glu Trp Leu Arg Lys Lys Leu Gln Asp Val His 
            20                  25                  30          


Asn Phe Val Ala Leu Gly Ala Pro Leu Ala Pro Arg Asp Ala Gly Ser 
        35                  40                  45              


Gln Arg Pro Arg Lys Lys Glu Asp Asn Val Leu Val Glu Ser His Glu 
    50                  55                  60                  


Lys Ser Leu Gly Glu Ala Asp Lys Ala Asp Val Asn Val Leu Thr Lys 
65                  70                  75                  80  


Ala Lys Ser Gln 
                


<210>  13
<211>  9
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificial PTH polypeptide.

<400>  13

Ser Val Ser Glu Ile Gln Leu Met His 
1               5                   


<210>  14
<211>  34
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificial PTH polypeptide.

<400>  14

Ser Val Ser Glu Ile Gln Leu Met His Asn Leu Gly Lys His Leu Asn 
1               5                   10                  15      


Ser Met Glu Arg Val Glu Trp Leu Arg Lys Lys Leu Gln Asp Val His 
            20                  25                  30          


Asn Phe 
        


<210>  15
<211>  34
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificial PTH polypeptide.


<220>
<221>  misc_feature
<222>  (1)..(1)
<223>  Xaa can be any naturally occurring amino acid

<220>
<221>  misc_feature
<222>  (7)..(7)
<223>  Xaa can be any naturally occurring amino acid

<400>  15

Xaa Val Ser Glu Ile Gln Xaa Met His Asn Leu Gly Lys His Leu Asn 
1               5                   10                  15      


Ser Met Glu Arg Val Glu Trp Leu Arg Lys Lys Leu Gln Asp Val His 
            20                  25                  30          


Asn Phe 
        


<210>  16
<211>  34
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificial PTH polypeptide.


<220>
<221>  misc_feature
<222>  (1)..(1)
<223>  Xaa can be any naturally occurring amino acid

<220>
<221>  misc_feature
<222>  (5)..(5)
<223>  Xaa can be any naturally occurring amino acid

<220>
<221>  misc_feature
<222>  (7)..(7)
<223>  Xaa can be any naturally occurring amino acid

<400>  16

Xaa Val Ser Glu Xaa Gln Xaa Met His Asn Leu Gly Lys His Leu Asn 
1               5                   10                  15      


Ser Met Glu Arg Val Glu Trp Leu Arg Lys Lys Leu Gln Asp Val His 
            20                  25                  30          


Asn Phe 
        


<210>  17
<211>  34
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificial PTH polypeptide.

<400>  17

Ser Val Ser Glu Ile Gln Leu Met His Asn Leu Gly Lys Trp Leu Asn 
1               5                   10                  15      


Ser Met Glu Arg Val Glu Trp Leu Arg Lys Lys Leu Gln Asp Val His 
            20                  25                  30          


Asn Phe 
        


<210>  18
<211>  34
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificial PTH polypeptide


<220>
<221>  misc_feature
<222>  (14)..(14)
<223>  Xaa can be any naturally occurring amino acid

<220>
<221>  misc_feature
<222>  (18)..(18)
<223>  Xaa can be any naturally occurring amino acid

<220>
<221>  misc_feature
<222>  (34)..(34)
<223>  Xaa can be any naturally occurring amino acid

<400>  18

Ser Val Ser Glu Ile Gln Leu Met His Asn Leu Gly Lys Xaa Leu Asn 
1               5                   10                  15      


Ser Xaa Glu Arg Val Glu Trp Leu Arg Glx Lys Leu Gln Asp Val His 
            20                  25                  30          


Asn Xaa 
        


<210>  19
<211>  34
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificial PTH polypeptide.


<220>
<221>  misc_feature
<222>  (14)..(14)
<223>  Xaa can be any naturally occurring amino acid

<220>
<221>  misc_feature
<222>  (18)..(18)
<223>  Xaa can be any naturally occurring amino acid

<220>
<221>  misc_feature
<222>  (30)..(30)
<223>  Xaa can be any naturally occurring amino acid

<220>
<221>  misc_feature
<222>  (34)..(34)
<223>  Xaa can be any naturally occurring amino acid

<400>  19

Ser Val Ser Glu Ile Gln Leu Met His Asn Leu Gly Lys Xaa Leu Asn 
1               5                   10                  15      


Ser Xaa Glu Arg Val Glx Trp Leu Arg Glx Lys Leu Gln Xaa Val His 
            20                  25                  30          


Asn Xaa 
        


<210>  20
<211>  34
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificial PTH polypeptide.


<220>
<221>  misc_feature
<222>  (1)..(1)
<223>  Xaa can be any naturally occurring amino acid

<220>
<221>  misc_feature
<222>  (7)..(7)
<223>  Xaa can be any naturally occurring amino acid

<400>  20

Xaa Val Ser Glu Ile Gln Xaa Met His Asn Leu Gly Lys Trp Leu Asn 
1               5                   10                  15      


Ser Met Glu Arg Val Glu Trp Leu Arg Lys Lys Leu Gln Asp Val His 
            20                  25                  30          


Asn Phe 
        


<210>  21
<211>  34
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificial PTH polypeptide.


<220>
<221>  misc_feature
<222>  (1)..(1)
<223>  Xaa can be any naturally occurring amino acid

<220>
<221>  misc_feature
<222>  (7)..(7)
<223>  Xaa can be any naturally occurring amino acid

<220>
<221>  misc_feature
<222>  (14)..(14)
<223>  Xaa can be any naturally occurring amino acid

<220>
<221>  misc_feature
<222>  (18)..(18)
<223>  Xaa can be any naturally occurring amino acid

<220>
<221>  misc_feature
<222>  (34)..(34)
<223>  Xaa can be any naturally occurring amino acid

<400>  21

Xaa Val Ser Glu Ile Gln Xaa Met His Asn Leu Gly Lys Xaa Leu Asn 
1               5                   10                  15      


Ser Xaa Glu Arg Val Glu Trp Leu Arg Glx Lys Leu Gln Asp Val His 
            20                  25                  30          


Asn Xaa 
        


<210>  22
<211>  34
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificial PTH polypeptide.


<220>
<221>  misc_feature
<222>  (1)..(1)
<223>  Xaa can be any naturally occurring amino acid

<220>
<221>  misc_feature
<222>  (7)..(7)
<223>  Xaa can be any naturally occurring amino acid

<220>
<221>  misc_feature
<222>  (14)..(14)
<223>  Xaa can be any naturally occurring amino acid

<220>
<221>  misc_feature
<222>  (18)..(18)
<223>  Xaa can be any naturally occurring amino acid

<220>
<221>  misc_feature
<222>  (30)..(30)
<223>  Xaa can be any naturally occurring amino acid

<220>
<221>  misc_feature
<222>  (34)..(34)
<223>  Xaa can be any naturally occurring amino acid

<400>  22

Xaa Val Ser Glu Ile Gln Xaa Met His Asn Leu Gly Lys Xaa Leu Asn 
1               5                   10                  15      


Ser Xaa Glu Arg Val Glx Trp Leu Arg Glx Lys Leu Gln Xaa Val His 
            20                  25                  30          


Asn Xaa 
        


<210>  23
<211>  34
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificial PTH polypeptide.


<220>
<221>  misc_feature
<222>  (1)..(1)
<223>  Xaa can be any naturally occurring amino acid

<220>
<221>  misc_feature
<222>  (5)..(5)
<223>  Xaa can be any naturally occurring amino acid

<220>
<221>  misc_feature
<222>  (7)..(7)
<223>  Xaa can be any naturally occurring amino acid

<400>  23

Xaa Val Ser Glu Xaa Gln Xaa Met His Asn Leu Gly Lys Trp Leu Asn 
1               5                   10                  15      


Ser Met Glu Arg Val Glu Trp Leu Arg Lys Lys Leu Gln Asp Val His 
            20                  25                  30          


Asn Phe 
        


<210>  24
<211>  34
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificial PTH polypeptide.


<220>
<221>  misc_feature
<222>  (1)..(1)
<223>  Xaa can be any naturally occurring amino acid

<220>
<221>  misc_feature
<222>  (5)..(5)
<223>  Xaa can be any naturally occurring amino acid

<220>
<221>  misc_feature
<222>  (7)..(7)
<223>  Xaa can be any naturally occurring amino acid

<220>
<221>  misc_feature
<222>  (14)..(14)
<223>  Xaa can be any naturally occurring amino acid

<220>
<221>  misc_feature
<222>  (18)..(18)
<223>  Xaa can be any naturally occurring amino acid

<220>
<221>  misc_feature
<222>  (34)..(34)
<223>  Xaa can be any naturally occurring amino acid

<400>  24

Xaa Val Ser Glu Xaa Gln Xaa Met His Asn Leu Gly Lys Xaa Leu Asn 
1               5                   10                  15      


Ser Xaa Glu Arg Val Glu Trp Leu Arg Glx Lys Leu Gln Asp Val His 
            20                  25                  30          


Asn Xaa 
        


<210>  25
<211>  34
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificial PTH polypeptide.


<220>
<221>  misc_feature
<222>  (1)..(1)
<223>  Xaa can be any naturally occurring amino acid

<220>
<221>  misc_feature
<222>  (5)..(5)
<223>  Xaa can be any naturally occurring amino acid

<220>
<221>  misc_feature
<222>  (7)..(7)
<223>  Xaa can be any naturally occurring amino acid

<220>
<221>  misc_feature
<222>  (14)..(14)
<223>  Xaa can be any naturally occurring amino acid

<220>
<221>  misc_feature
<222>  (18)..(18)
<223>  Xaa can be any naturally occurring amino acid

<220>
<221>  misc_feature
<222>  (30)..(30)
<223>  Xaa can be any naturally occurring amino acid

<220>
<221>  misc_feature
<222>  (34)..(34)
<223>  Xaa can be any naturally occurring amino acid

<400>  25

Xaa Val Ser Glu Xaa Gln Xaa Met His Asn Leu Gly Lys Xaa Leu Asn 
1               5                   10                  15      


Ser Xaa Glu Arg Val Glx Trp Leu Arg Glx Lys Leu Gln Xaa Val His 
            20                  25                  30          


Asn Xaa 
        


<210>  26
<211>  34
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificial PTH polypeptide.

<400>  26

Ala Val Ala Glu Ile Gln Leu Met His Gln Arg Ala Lys Trp Leu Asn 
1               5                   10                  15      


Ser Met Arg Arg Val Glu Trp Leu Arg Lys Lys Leu Gln Asp Val His 
            20                  25                  30          


Asn Phe 
        


<210>  27
<211>  34
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificial PTH polypeptide.


<220>
<221>  misc_feature
<222>  (1)..(1)
<223>  Xaa can be any naturally occurring amino acid

<220>
<221>  misc_feature
<222>  (3)..(3)
<223>  Xaa can be any naturally occurring amino acid

<220>
<221>  misc_feature
<222>  (7)..(7)
<223>  Xaa can be any naturally occurring amino acid

<400>  27

Xaa Val Xaa Glu Ile Gln Xaa Met His Gln Arg Ala Lys Trp Leu Asn 
1               5                   10                  15      


Ser Met Arg Arg Val Glu Trp Leu Arg Lys Lys Leu Gln Asp Val His 
            20                  25                  30          


Asn Phe 
        


<210>  28
<211>  34
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificial PTH polypeptide.


<220>
<221>  misc_feature
<222>  (1)..(1)
<223>  Xaa can be any naturally occurring amino acid

<220>
<221>  misc_feature
<222>  (3)..(3)
<223>  Xaa can be any naturally occurring amino acid

<220>
<221>  misc_feature
<222>  (5)..(5)
<223>  Xaa can be any naturally occurring amino acid

<220>
<221>  misc_feature
<222>  (7)..(7)
<223>  Xaa can be any naturally occurring amino acid

<400>  28

Xaa Val Xaa Glu Xaa Gln Xaa Met His Gln Arg Ala Lys Trp Leu Asn 
1               5                   10                  15      


Ser Met Arg Arg Val Glu Trp Leu Arg Lys Lys Leu Gln Asp Val His 
            20                  25                  30          


Asn Phe 
        


<210>  29
<211>  34
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificial PTH polypeptide.


<220>
<221>  misc_feature
<222>  (7)..(7)
<223>  Xaa can be any naturally occurring amino acid

<400>  29

Ala Val Ala Glu Ile Gln Xaa Met His Gln Arg Ala Lys Trp Leu Asn 
1               5                   10                  15      


Ser Met Arg Arg Val Glu Trp Leu Arg Lys Lys Leu Gln Asp Val His 
            20                  25                  30          


Asn Phe 
        


<210>  30
<211>  34
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificial PTH polypeptide.


<220>
<221>  misc_feature
<222>  (7)..(7)
<223>  Xaa can be any naturally occurring amino acid

<220>
<221>  misc_feature
<222>  (14)..(14)
<223>  Xaa can be any naturally occurring amino acid

<220>
<221>  misc_feature
<222>  (18)..(18)
<223>  Xaa can be any naturally occurring amino acid

<220>
<221>  misc_feature
<222>  (34)..(34)
<223>  Xaa can be any naturally occurring amino acid

<400>  30

Ala Val Ala Glu Ile Gln Xaa Met His Gln Arg Ala Lys Xaa Leu Asn 
1               5                   10                  15      


Ser Xaa Arg Arg Val Glu Trp Leu Arg Glx Lys Leu Gln Asp Val His 
            20                  25                  30          


Asn Xaa 
        


<210>  31
<211>  34
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificial PTH polypeptide.


<220>
<221>  misc_feature
<222>  (7)..(7)
<223>  Xaa can be any naturally occurring amino acid

<220>
<221>  misc_feature
<222>  (14)..(14)
<223>  Xaa can be any naturally occurring amino acid

<220>
<221>  misc_feature
<222>  (18)..(18)
<223>  Xaa can be any naturally occurring amino acid

<220>
<221>  misc_feature
<222>  (30)..(30)
<223>  Xaa can be any naturally occurring amino acid

<220>
<221>  misc_feature
<222>  (34)..(34)
<223>  Xaa can be any naturally occurring amino acid

<400>  31

Ala Val Ala Glu Ile Gln Xaa Met His Gln Arg Ala Lys Xaa Leu Asn 
1               5                   10                  15      


Ser Xaa Arg Arg Val Glx Trp Leu Arg Glx Lys Leu Gln Xaa Val His 
            20                  25                  30          


Asn Xaa 
        


<210>  32
<211>  34
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificial PTH polypeptide.


<220>
<221>  misc_feature
<222>  (1)..(1)
<223>  Xaa can be any naturally occurring amino acid

<220>
<221>  misc_feature
<222>  (3)..(3)
<223>  Xaa can be any naturally occurring amino acid

<220>
<221>  misc_feature
<222>  (7)..(7)
<223>  Xaa can be any naturally occurring amino acid

<400>  32

Xaa Val Xaa Glu Ile Gln Xaa Met His Gln Arg Ala Lys Trp Leu Asn 
1               5                   10                  15      


Ser Met Arg Arg Val Glu Trp Leu Arg Lys Lys Leu Gln Asp Val His 
            20                  25                  30          


Asn Phe 
        


<210>  33
<211>  34
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificial PTH polypeptide.


<220>
<221>  misc_feature
<222>  (1)..(1)
<223>  Xaa can be any naturally occurring amino acid

<220>
<221>  misc_feature
<222>  (3)..(3)
<223>  Xaa can be any naturally occurring amino acid

<220>
<221>  misc_feature
<222>  (7)..(7)
<223>  Xaa can be any naturally occurring amino acid

<220>
<221>  misc_feature
<222>  (14)..(14)
<223>  Xaa can be any naturally occurring amino acid

<220>
<221>  misc_feature
<222>  (18)..(18)
<223>  Xaa can be any naturally occurring amino acid

<220>
<221>  misc_feature
<222>  (34)..(34)
<223>  Xaa can be any naturally occurring amino acid

<400>  33

Xaa Val Xaa Glu Ile Gln Xaa Met His Gln Arg Ala Lys Xaa Leu Asn 
1               5                   10                  15      


Ser Xaa Arg Arg Val Glu Trp Leu Arg Glx Lys Leu Gln Asp Val His 
            20                  25                  30          


Asn Xaa 
        


<210>  34
<211>  34
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificial PTH polypeptide.


<220>
<221>  misc_feature
<222>  (1)..(1)
<223>  Xaa can be any naturally occurring amino acid

<220>
<221>  misc_feature
<222>  (3)..(3)
<223>  Xaa can be any naturally occurring amino acid

<220>
<221>  misc_feature
<222>  (7)..(7)
<223>  Xaa can be any naturally occurring amino acid

<220>
<221>  misc_feature
<222>  (14)..(14)
<223>  Xaa can be any naturally occurring amino acid

<220>
<221>  misc_feature
<222>  (18)..(18)
<223>  Xaa can be any naturally occurring amino acid

<220>
<221>  misc_feature
<222>  (30)..(30)
<223>  Xaa can be any naturally occurring amino acid

<220>
<221>  misc_feature
<222>  (34)..(34)
<223>  Xaa can be any naturally occurring amino acid

<400>  34

Xaa Val Xaa Glu Ile Gln Xaa Met His Gln Arg Ala Lys Xaa Leu Asn 
1               5                   10                  15      


Ser Xaa Arg Arg Val Glx Trp Leu Arg Glx Lys Leu Gln Xaa Val His 
            20                  25                  30          


Asn Xaa 
        


<210>  35
<211>  34
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificial PTH polypeptide.


<220>
<221>  misc_feature
<222>  (1)..(1)
<223>  Xaa can be any naturally occurring amino acid

<220>
<221>  misc_feature
<222>  (3)..(3)
<223>  Xaa can be any naturally occurring amino acid

<220>
<221>  misc_feature
<222>  (5)..(5)
<223>  Xaa can be any naturally occurring amino acid

<220>
<221>  misc_feature
<222>  (7)..(7)
<223>  Xaa can be any naturally occurring amino acid

<400>  35

Xaa Val Xaa Glu Xaa Gln Xaa Met His Gln Arg Ala Lys Trp Leu Asn 
1               5                   10                  15      


Ser Met Arg Arg Val Glu Trp Leu Arg Lys Lys Leu Gln Asp Val His 
            20                  25                  30          


Asn Phe 
        


<210>  36
<211>  35
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificial PTH polypeptide.


<220>
<221>  misc_feature
<222>  (2)..(2)
<223>  Xaa can be any naturally occurring amino acid

<220>
<221>  misc_feature
<222>  (4)..(4)
<223>  Xaa can be any naturally occurring amino acid

<220>
<221>  misc_feature
<222>  (6)..(6)
<223>  Xaa can be any naturally occurring amino acid

<220>
<221>  misc_feature
<222>  (8)..(8)
<223>  Xaa can be any naturally occurring amino acid

<220>
<221>  misc_feature
<222>  (15)..(15)
<223>  Xaa can be any naturally occurring amino acid

<220>
<221>  misc_feature
<222>  (19)..(19)
<223>  Xaa can be any naturally occurring amino acid

<220>
<221>  misc_feature
<222>  (35)..(35)
<223>  Xaa can be any naturally occurring amino acid

<400>  36

His Xaa Val Xaa Glu Xaa Gln Xaa Met His Gln Arg Ala Lys Xaa Leu 
1               5                   10                  15      


Asn Ser Xaa Arg Arg Val Glu Trp Leu Arg Glx Lys Leu Gln Asp Val 
            20                  25                  30          


His Asn Xaa 
        35  


<210>  37
<211>  34
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificial PTH polypeptide.


<220>
<221>  misc_feature
<222>  (1)..(1)
<223>  Xaa can be any naturally occurring amino acid

<220>
<221>  misc_feature
<222>  (3)..(3)
<223>  Xaa can be any naturally occurring amino acid

<220>
<221>  misc_feature
<222>  (5)..(5)
<223>  Xaa can be any naturally occurring amino acid

<220>
<221>  misc_feature
<222>  (7)..(7)
<223>  Xaa can be any naturally occurring amino acid

<220>
<221>  misc_feature
<222>  (14)..(14)
<223>  Xaa can be any naturally occurring amino acid

<220>
<221>  misc_feature
<222>  (18)..(18)
<223>  Xaa can be any naturally occurring amino acid

<220>
<221>  misc_feature
<222>  (30)..(30)
<223>  Xaa can be any naturally occurring amino acid

<220>
<221>  misc_feature
<222>  (34)..(34)
<223>  Xaa can be any naturally occurring amino acid

<400>  37

Xaa Val Xaa Glu Xaa Gln Xaa Met His Gln Arg Ala Lys Xaa Leu Asn 
1               5                   10                  15      


Ser Xaa Arg Arg Val Glx Trp Leu Arg Glx Lys Leu Gln Xaa Val His 
            20                  25                  30          


Asn Xaa 
        


<210>  38
<211>  34
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificial PTH polypeptide.


<220>
<221>  misc_feature
<222>  (5)..(5)
<223>  Xaa can be any naturally occurring amino acid

<220>
<221>  misc_feature
<222>  (7)..(7)
<223>  Xaa can be any naturally occurring amino acid

<220>
<221>  misc_feature
<222>  (14)..(14)
<223>  Xaa can be any naturally occurring amino acid

<220>
<221>  misc_feature
<222>  (18)..(18)
<223>  Xaa can be any naturally occurring amino acid

<220>
<221>  misc_feature
<222>  (30)..(30)
<223>  Xaa can be any naturally occurring amino acid

<220>
<221>  misc_feature
<222>  (34)..(34)
<223>  Xaa can be any naturally occurring amino acid

<400>  38

Ser Val Ser Glu Xaa Gln Xaa Met His Asn Leu Gly Lys Xaa Leu Asn 
1               5                   10                  15      


Ser Xaa Glu Arg Val Glx Trp Leu Arg Glx Lys Leu Gln Xaa Val His 
            20                  25                  30          


Asn Xaa 
        


<210>  39
<211>  34
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificial PTH polypeptide.


<220>
<221>  misc_feature
<222>  (3)..(3)
<223>  Xaa can be any naturally occurring amino acid

<220>
<221>  misc_feature
<222>  (7)..(7)
<223>  Xaa can be any naturally occurring amino acid

<220>
<221>  misc_feature
<222>  (14)..(14)
<223>  Xaa can be any naturally occurring amino acid

<220>
<221>  misc_feature
<222>  (18)..(18)
<223>  Xaa can be any naturally occurring amino acid

<220>
<221>  misc_feature
<222>  (30)..(30)
<223>  Xaa can be any naturally occurring amino acid

<220>
<221>  misc_feature
<222>  (34)..(34)
<223>  Xaa can be any naturally occurring amino acid

<400>  39

Ser Val Xaa Glu Ile Gln Xaa Met His Asn Leu Gly Lys Xaa Leu Asn 
1               5                   10                  15      


Ser Xaa Glu Arg Val Glx Trp Leu Arg Glx Lys Leu Gln Xaa Val His 
            20                  25                  30          


Asn Xaa 
        


<210>  40
<211>  34
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificial PTH polypeptide.


<220>
<221>  misc_feature
<222>  (29)..(29)
<223>  Xaa can be any naturally occurring amino acid

<400>  40

Ala Val Ser Glu His Gln Leu Leu His Asp Lys Gly Lys Ser Ile Gln 
1               5                   10                  15      


Asp Leu Arg Arg Arg Glu Leu Leu Glu Lys Leu Leu Xaa Lys Leu His 
            20                  25                  30          


Thr Ala 
        


<210>  41
<211>  34
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificial PTH polypeptide.


<220>
<221>  misc_feature
<222>  (29)..(29)
<223>  Xaa can be any naturally occurring amino acid

<400>  41

Ala Val Ser Glu His Gln Leu Leu His Asp Lys Gly Lys Ser Ile Gln 
1               5                   10                  15      


Asp Leu Arg Arg Arg Glu Leu Leu Glu Lys Leu Leu Xaa Lys Leu His 
            20                  25                  30          


Thr Ala 
        


<210>  42
<211>  34
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificial PTH polypeptide.


<220>
<221>  misc_feature
<222>  (14)..(14)
<223>  Xaa can be any naturally occurring amino acid

<220>
<221>  misc_feature
<222>  (18)..(18)
<223>  Xaa can be any naturally occurring amino acid

<220>
<221>  misc_feature
<222>  (29)..(30)
<223>  Xaa can be any naturally occurring amino acid

<220>
<221>  misc_feature
<222>  (34)..(34)
<223>  Xaa can be any naturally occurring amino acid

<400>  42

Ala Val Ser Glu His Gln Leu Leu His Asp Lys Gly Lys Xaa Ile Gln 
1               5                   10                  15      


Asp Xaa Arg Arg Arg Glx Leu Leu Glu Glx Leu Leu Xaa Xaa Leu His 
            20                  25                  30          


Thr Xaa 
        


<210>  43
<211>  34
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificial PTH polypeptide.


<220>
<221>  misc_feature
<222>  (1)..(1)
<223>  Xaa can be any naturally occurring amino acid

<220>
<221>  misc_feature
<222>  (7)..(7)
<223>  Xaa can be any naturally occurring amino acid

<220>
<221>  misc_feature
<222>  (29)..(29)
<223>  Xaa can be any naturally occurring amino acid

<400>  43

Xaa Val Ser Glu His Gln Xaa Leu His Asp Lys Gly Lys Ser Ile Gln 
1               5                   10                  15      


Asp Leu Arg Arg Arg Glu Leu Leu Glu Lys Leu Leu Xaa Lys Leu His 
            20                  25                  30          


Thr Ala 
        


<210>  44
<211>  34
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificial PTH polypeptide.


<220>
<221>  misc_feature
<222>  (1)..(1)
<223>  Xaa can be any naturally occurring amino acid

<220>
<221>  misc_feature
<222>  (7)..(7)
<223>  Xaa can be any naturally occurring amino acid

<220>
<221>  misc_feature
<222>  (29)..(29)
<223>  Xaa can be any naturally occurring amino acid

<220>
<221>  misc_feature
<222>  (34)..(34)
<223>  Xaa can be any naturally occurring amino acid

<400>  44

Xaa Val Ser Glu His Gln Xaa Leu His Asp Lys Gly Lys Ser Ile Gln 
1               5                   10                  15      


Asp Leu Arg Arg Arg Glu Leu Leu Glu Lys Leu Leu Xaa Lys Leu His 
            20                  25                  30          


Thr Xaa 
        


<210>  45
<211>  34
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificial PTH polypeptide.


<220>
<221>  misc_feature
<222>  (1)..(1)
<223>  Xaa can be any naturally occurring amino acid

<220>
<221>  misc_feature
<222>  (7)..(7)
<223>  Xaa can be any naturally occurring amino acid

<220>
<221>  misc_feature
<222>  (14)..(14)
<223>  Xaa can be any naturally occurring amino acid

<220>
<221>  misc_feature
<222>  (18)..(18)
<223>  Xaa can be any naturally occurring amino acid

<220>
<221>  misc_feature
<222>  (29)..(30)
<223>  Xaa can be any naturally occurring amino acid

<220>
<221>  misc_feature
<222>  (34)..(34)
<223>  Xaa can be any naturally occurring amino acid

<400>  45

Xaa Val Ser Glu His Gln Xaa Leu His Asp Lys Gly Lys Xaa Ile Gln 
1               5                   10                  15      


Asp Xaa Arg Arg Arg Glx Leu Leu Glu Glx Leu Leu Xaa Xaa Leu His 
            20                  25                  30          


Thr Xaa 
        


<210>  46
<211>  34
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificial PTH polypeptide.


<220>
<221>  misc_feature
<222>  (1)..(1)
<223>  Xaa can be any naturally occurring amino acid

<220>
<221>  misc_feature
<222>  (5)..(5)
<223>  Xaa can be any naturally occurring amino acid

<220>
<221>  misc_feature
<222>  (7)..(7)
<223>  Xaa can be any naturally occurring amino acid

<220>
<221>  misc_feature
<222>  (29)..(29)
<223>  Xaa can be any naturally occurring amino acid

<400>  46

Xaa Val Ser Glu Xaa Gln Xaa Leu His Asp Lys Gly Lys Ser Ile Gln 
1               5                   10                  15      


Asp Leu Arg Arg Arg Glu Leu Leu Glu Lys Leu Leu Xaa Lys Leu His 
            20                  25                  30          


Thr Ala 
        


<210>  47
<211>  34
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificial PTH polypeptide.


<220>
<221>  misc_feature
<222>  (1)..(1)
<223>  Xaa can be any naturally occurring amino acid

<220>
<221>  misc_feature
<222>  (5)..(5)
<223>  Xaa can be any naturally occurring amino acid

<220>
<221>  misc_feature
<222>  (7)..(7)
<223>  Xaa can be any naturally occurring amino acid

<220>
<221>  misc_feature
<222>  (29)..(29)
<223>  Xaa can be any naturally occurring amino acid

<220>
<221>  misc_feature
<222>  (34)..(34)
<223>  Xaa can be any naturally occurring amino acid

<400>  47

Xaa Val Ser Glu Xaa Gln Xaa Leu His Asp Lys Gly Lys Ser Ile Gln 
1               5                   10                  15      


Asp Leu Arg Arg Arg Glu Leu Leu Glu Lys Leu Leu Xaa Lys Leu His 
            20                  25                  30          


Thr Xaa 
        


<210>  48
<211>  34
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificial PTH polypeptide.


<220>
<221>  misc_feature
<222>  (1)..(1)
<223>  Xaa can be any naturally occurring amino acid

<220>
<221>  misc_feature
<222>  (5)..(5)
<223>  Xaa can be any naturally occurring amino acid

<220>
<221>  misc_feature
<222>  (7)..(7)
<223>  Xaa can be any naturally occurring amino acid

<220>
<221>  misc_feature
<222>  (14)..(14)
<223>  Xaa can be any naturally occurring amino acid

<220>
<221>  misc_feature
<222>  (18)..(18)
<223>  Xaa can be any naturally occurring amino acid

<220>
<221>  misc_feature
<222>  (29)..(30)
<223>  Xaa can be any naturally occurring amino acid

<220>
<221>  misc_feature
<222>  (34)..(34)
<223>  Xaa can be any naturally occurring amino acid

<400>  48

Xaa Val Ser Glu Xaa Gln Xaa Leu His Asp Lys Gly Lys Xaa Ile Gln 
1               5                   10                  15      


Asp Xaa Arg Arg Arg Glx Leu Leu Glu Glx Leu Leu Xaa Xaa Leu His 
            20                  25                  30          


Thr Xaa 
        


<210>  49
<211>  34
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificial PTH polypeptide.

<400>  49

Ser Val Ser Glu Ile Gln Leu Met His Asn Leu Gly Lys His Leu Asn 
1               5                   10                  15      


Ser Met Glu Arg Val Glu Trp Leu Arg Lys Lys Leu Gln Asp Val His 
            20                  25                  30          


Asn Phe 
        


<210>  50
<211>  34
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificial PTH polypeptide.

<400>  50

Ala Val Ser Glu His Gln Leu Leu His Asp Lys Gly Lys Ser Ile Gln 
1               5                   10                  15      


Asp Leu Arg Arg Arg Phe Phe Leu His His Leu Ile Ala Glu Ile His 
            20                  25                  30          


Thr Ala 
        


<210>  51
<211>  34
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificial PTH polypeptide.

<400>  51

Ala Val Ser Glu His Gln Leu Leu His Asp Lys Gly Lys Ser Ile Gln 
1               5                   10                  15      


Asp Leu Arg Arg Arg Phe Phe Leu His Lys Leu Ile Ala Glu Ile His 
            20                  25                  30          


Thr Ala 
        


<210>  52
<211>  34
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificial PTH polypeptide.


<220>
<221>  misc_feature
<222>  (14)..(14)
<223>  Xaa can be any naturally occurring amino acid

<220>
<221>  misc_feature
<222>  (18)..(18)
<223>  Xaa can be any naturally occurring amino acid

<220>
<221>  misc_feature
<222>  (30)..(30)
<223>  Xaa can be any naturally occurring amino acid

<220>
<221>  misc_feature
<222>  (34)..(34)
<223>  Xaa can be any naturally occurring amino acid

<400>  52

Ala Val Ser Glu His Gln Leu Leu His Asp Lys Gly Lys Xaa Ile Gln 
1               5                   10                  15      


Asp Xaa Arg Arg Arg Glx Phe Leu His Glx Leu Ile Ala Xaa Ile His 
            20                  25                  30          


Thr Xaa 
        


<210>  53
<211>  34
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificial PTH polypeptide.


<220>
<221>  misc_feature
<222>  (1)..(1)
<223>  Xaa can be any naturally occurring amino acid

<220>
<221>  misc_feature
<222>  (5)..(5)
<223>  Xaa can be any naturally occurring amino acid

<220>
<221>  misc_feature
<222>  (7)..(7)
<223>  Xaa can be any naturally occurring amino acid

<400>  53

Xaa Val Ser Glu Xaa Gln Xaa Leu His Asp Lys Gly Lys Ser Ile Gln 
1               5                   10                  15      


Asp Leu Arg Arg Arg Phe Phe Leu His Lys Leu Ile Ala Glu Ile His 
            20                  25                  30          


Thr Ala 
        


<210>  54
<211>  34
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificial PTH polypeptide.


<220>
<221>  misc_feature
<222>  (1)..(1)
<223>  Xaa can be any naturally occurring amino acid

<220>
<221>  misc_feature
<222>  (5)..(5)
<223>  Xaa can be any naturally occurring amino acid

<220>
<221>  misc_feature
<222>  (7)..(7)
<223>  Xaa can be any naturally occurring amino acid

<220>
<221>  misc_feature
<222>  (14)..(14)
<223>  Xaa can be any naturally occurring amino acid

<220>
<221>  misc_feature
<222>  (18)..(18)
<223>  Xaa can be any naturally occurring amino acid

<220>
<221>  misc_feature
<222>  (30)..(30)
<223>  Xaa can be any naturally occurring amino acid

<220>
<221>  misc_feature
<222>  (34)..(34)
<223>  Xaa can be any naturally occurring amino acid

<400>  54

Xaa Val Ser Glu Xaa Gln Xaa Leu His Asp Lys Gly Lys Xaa Ile Gln 
1               5                   10                  15      


Asp Xaa Arg Arg Arg Glx Phe Leu His Glx Leu Ile Ala Xaa Ile His 
            20                  25                  30          


Thr Xaa 
        


<210>  55
<211>  28
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificial PTH polypeptide.

<400>  55

Leu Met His Asn Leu Gly Lys His Leu Asn Ser Met Glu Arg Val Glu 
1               5                   10                  15      


Trp Leu Arg Lys Lys Leu Gln Asp Val His Asn Phe 
            20                  25              


<210>  56
<211>  28
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificial PTH polypeptide.

<400>  56

Phe Met His Asn Leu Gly Lys His Leu Ser Ser Met Glu Arg Val Glu 
1               5                   10                  15      


Trp Leu Arg Lys Lys Leu Gln Asp Val His Asn Phe 
            20                  25              


<210>  57
<211>  28
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificial PTH polypeptide.

<400>  57

Phe Met His Asn Leu Trp Lys His Leu Ser Ser Met Glu Arg Val Glu 
1               5                   10                  15      


Trp Leu Arg Lys Lys Leu Gln Asp Val His Asn Phe 
            20                  25              


<210>  58
<211>  28
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificial PTH polypeptide.

<400>  58

Phe Met His Asn Leu Trp Lys Trp Leu Ser Ser Met Glu Arg Val Glu 
1               5                   10                  15      


Trp Leu Arg Lys Lys Leu Gln Asp Val His Asn Phe 
            20                  25              


<210>  59
<211>  28
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificial PTH polypeptide.


<220>
<221>  misc_feature
<222>  (1)..(1)
<223>  Xaa can be any naturally occurring amino acid

<400>  59

Xaa Met His Asn Leu Trp Lys Trp Leu Ser Ser Met Glu Arg Val Glu 
1               5                   10                  15      


Trp Leu Arg Lys Lys Leu Gln Asp Val His Asn Phe 
            20                  25              


<210>  60
<211>  28
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificial PTH polypeptide.


<220>
<221>  misc_feature
<222>  (1)..(1)
<223>  Xaa can be any naturally occurring amino acid

<220>
<221>  misc_feature
<222>  (8)..(8)
<223>  Xaa can be any naturally occurring amino acid

<220>
<221>  misc_feature
<222>  (12)..(12)
<223>  Xaa can be any naturally occurring amino acid

<220>
<221>  misc_feature
<222>  (24)..(24)
<223>  Xaa can be any naturally occurring amino acid

<220>
<221>  misc_feature
<222>  (28)..(28)
<223>  Xaa can be any naturally occurring amino acid

<400>  60

Xaa Met His Asn Leu Trp Lys Xaa Leu Ser Ser Xaa Glu Arg Val Glx 
1               5                   10                  15      


Trp Leu Arg Glx Lys Leu Gln Xaa Val His Asn Xaa 
            20                  25              


