                         SEQUENCE LISTING

<110>  Santaris Pharma A/S
 
<120>  Antisense oligomers and conjugates targeting PCSK9

<130>  1141WO

<160>  46    

<170>  PatentIn version 3.5

<210>  1
<211>  14
<212>  DNA
<213>  ARTIFICIAL

<220>
<223>  LNA antisense gapmer oligonucleotide


<220>
<221>  misc_feature
<222>  (1)..(14)
<223>  phosphorothioate lnternucleoside linkages

<220>
<221>  misc_feature
<222>  (1)..(3)
<223>  LNA nucleosides, LNA C are 5-methyl C

<220>
<221>  misc_feature
<222>  (12)..(14)
<223>  LNA nucleosides, LNA C are 5-methyl C

<400>  1
tgctacaaaa ccca                                                         14


<210>  2
<211>  16
<212>  DNA
<213>  ARTIFICIAL

<220>
<223>  LNA antisense gapmer oligonucleotide


<220>
<221>  misc_feature
<222>  (1)..(16)
<223>  phosphorothioate lnternucleoside linkages

<220>
<221>  misc_feature
<222>  (1)..(3)
<223>  LNA nucleosides

<220>
<221>  misc_feature
<222>  (13)..(16)
<223>  LNA nucleosides, LNA C are 5-methyl C

<400>  2
aatgctacaa aaccca                                                       16


<210>  3
<211>  16
<212>  DNA
<213>  ARTIFICIAL

<220>
<223>  LNA antisense gapmer oligonucleotide


<220>
<221>  misc_feature
<222>  (1)..(16)
<223>  phosphorothioate lnternucleoside linkages

<220>
<221>  misc_feature
<222>  (1)..(3)
<223>  LNA nucleosides

<220>
<221>  misc_feature
<222>  (14)..(16)
<223>  LNA nucleosides, LNA C are 5-methyl C

<400>  3
aatgctacaa aaccca                                                       16


<210>  4
<211>  15
<212>  DNA
<213>  ARTIFICIAL

<220>
<223>  LNA antisense gapmer oligonucleotide


<220>
<221>  misc_feature
<222>  (1)..(15)
<223>  phosphorothioate lnternucleoside linkages

<220>
<221>  misc_feature
<222>  (1)..(2)
<223>  LNA nucleosides, LNA C are 5-methyl C

<220>
<221>  misc_feature
<222>  (14)..(15)
<223>  LNA nucleosides

<400>  4
gctgtgtgag cttgg                                                        15


<210>  5
<211>  16
<212>  DNA
<213>  ARTIFICIAL

<220>
<223>  LNA antisense gapmer oligonucleotide


<220>
<221>  misc_feature
<222>  (1)..(2)
<223>  LNA nucleosides

<220>
<221>  misc_feature
<222>  (1)..(16)
<223>  phosphorothioate lnternucleoside linkages

<220>
<221>  misc_feature
<222>  (14)..(16)
<223>  LNA nucleosides

<400>  5
tgctgtgtga gcttgg                                                       16


<210>  6
<211>  16
<212>  DNA
<213>  ARTIFICIAL

<220>
<223>  LNA antisense gapmer oligonucleotide


<220>
<221>  misc_feature
<222>  (1)..(16)
<223>  phosphorothioate lnternucleoside linkages

<220>
<221>  misc_feature
<222>  (1)..(3)
<223>  LNA nucleosides, LNA C are 5-methyl C

<220>
<221>  misc_feature
<222>  (14)..(16)
<223>  LNA nucleosides

<400>  6
tgctgtgtga gcttgg                                                       16


<210>  7
<211>  16
<212>  DNA
<213>  ARTIFICIAL

<220>
<223>  LNA antisense gapmer oligonucleotide


<220>
<221>  misc_feature
<222>  (1)..(16)
<223>  phosphorothioate lnternucleoside linkages

<220>
<221>  misc_feature
<222>  (1)..(3)
<223>  LNA nucleosides, LNA C are 5-methyl C

<220>
<221>  misc_feature
<222>  (14)..(16)
<223>  LNA nucleosides, LNA C are 5-methyl C

<400>  7
tcctggtctg tgttcc                                                       16


<210>  8
<211>  16
<212>  DNA
<213>  artificial

<220>
<223>  LNA antisense gapmer oligonucleotide


<220>
<221>  misc_feature
<222>  (1)..(16)
<223>  phosphorothioate lnternucleoside linkages

<220>
<221>  misc_feature
<222>  (1)..(3)
<223>  LNA nucleosides, LNA C are 5-methyl C

<220>
<221>  misc_feature
<222>  (15)..(16)
<223>  LNA nucleosides, LNA C are 5-methyl C

<400>  8
tcctggtctg tgttcc                                                       16


<210>  9
<211>  16
<212>  DNA
<213>  ARTIFICIAL

<220>
<223>  LNA antisense gapmer oligonucleotide conjugate


<220>
<221>  misc_feature
<222>  (1)..(1)
<223>  Cholesterol-C6

<220>
<221>  misc_feature
<222>  (1)..(2)
<223>  phosphodiester lnternucleoside linkages

<220>
<221>  misc_feature
<222>  (3)..(16)
<223>  phosphorothioate lnternucleoside linkages

<220>
<221>  misc_feature
<222>  (3)..(5)
<223>  LNA nucleosides, LNA C are 5-methyl C

<220>
<221>  misc_feature
<222>  (14)..(16)
<223>  LNA nucleosides, LNA C are 5-methyl C

<400>  9
catgctacaa aaccca                                                       16


<210>  10
<211>  18
<212>  DNA
<213>  ARTIFICIAL

<220>
<223>  LNA antisense gapmer oligonucleotide conjugate


<220>
<221>  misc_feature
<222>  (1)..(1)
<223>  Cholesterol-C6

<220>
<221>  misc_feature
<222>  (1)..(2)
<223>  phosphodiester lnternucleoside linkages

<220>
<221>  misc_feature
<222>  (3)..(18)
<223>  phosphorothioate lnternucleoside linkages

<220>
<221>  misc_feature
<222>  (3)..(5)
<223>  LNA nucleosides

<220>
<221>  misc_feature
<222>  (15)..(18)
<223>  LNA nucleosides, LNA C are 5-methyl C

<400>  10
caaatgctac aaaaccca                                                     18


<210>  11
<211>  18
<212>  DNA
<213>  ARTIFICIAL

<220>
<223>  LNA antisense gapmer oligonucleotide conjugate


<220>
<221>  misc_feature
<222>  (1)..(1)
<223>  Cholesterol-C6

<220>
<221>  misc_feature
<222>  (1)..(2)
<223>  phosphodiester lnternucleoside linkages

<220>
<221>  misc_feature
<222>  (3)..(18)
<223>  phosphorothioate lnternucleoside linkages

<220>
<221>  misc_feature
<222>  (3)..(5)
<223>  LNA nucleosides

<220>
<221>  misc_feature
<222>  (16)..(18)
<223>  LNA nucleosides, LNA C are 5-methyl C

<400>  11
caaatgctac aaaaccca                                                     18


<210>  12
<211>  17
<212>  DNA
<213>  ARTIFICIAL

<220>
<223>  LNA antisense gapmer oligonucleotide conjugate


<220>
<221>  misc_feature
<222>  (1)..(1)
<223>  Cholesterol-C6

<220>
<221>  misc_feature
<222>  (1)..(2)
<223>  phosphodiester lnternucleoside linkages

<220>
<221>  misc_feature
<222>  (3)..(17)
<223>  phosphorothioate lnternucleoside linkages

<220>
<221>  misc_feature
<222>  (3)..(4)
<223>  LNA nucleosides, LNA C are 5-methyl C

<220>
<221>  misc_feature
<222>  (16)..(17)
<223>  LNA nucleosides

<400>  12
cagctgtgtg agcttgg                                                      17


<210>  13
<211>  18
<212>  DNA
<213>  ARTIFICIAL

<220>
<223>  LNA antisense gapmer oligonucleotide conjugate


<220>
<221>  misc_feature
<222>  (1)..(1)
<223>  Cholesterol-C6

<220>
<221>  misc_feature
<222>  (1)..(2)
<223>  phosphodiester lnternucleoside linkages

<220>
<221>  misc_feature
<222>  (3)..(4)
<223>  LNA nucleosides

<220>
<221>  misc_feature
<222>  (3)..(18)
<223>  phosphorothioate lnternucleoside linkages

<220>
<221>  misc_feature
<222>  (16)..(18)
<223>  LNA nucleosides

<400>  13
catgctgtgt gagcttgg                                                     18


<210>  14
<211>  18
<212>  DNA
<213>  ARTIFICIAL

<220>
<223>  LNA antisense gapmer oligonucleotide conjugate


<220>
<221>  misc_feature
<222>  (1)..(1)
<223>  Cholesterol-C6

<220>
<221>  misc_feature
<222>  (1)..(2)
<223>  phosphodiester lnternucleoside linkages

<220>
<221>  misc_feature
<222>  (3)..(18)
<223>  phosphorothioate lnternucleoside linkages

<220>
<221>  misc_feature
<222>  (3)..(5)
<223>  LNA nucleosides, LNA C are 5-methyl C

<220>
<221>  misc_feature
<222>  (16)..(18)
<223>  LNA nucleosides

<400>  14
catgctgtgt gagcttgg                                                     18


<210>  15
<211>  18
<212>  DNA
<213>  ARTIFICIAL

<220>
<223>  LNA antisense gapmer oligonucleotide conjugate


<220>
<221>  misc_feature
<222>  (1)..(1)
<223>  Cholesterol-C6

<220>
<221>  misc_feature
<222>  (1)..(2)
<223>  phosphodiester lnternucleoside linkages

<220>
<221>  misc_feature
<222>  (3)..(18)
<223>  phosphorothioate lnternucleoside linkages

<220>
<221>  misc_feature
<222>  (3)..(5)
<223>  LNA nucleosides, LNA C are 5-methyl C

<220>
<221>  misc_feature
<222>  (16)..(18)
<223>  LNA nucleosides, LNA C are 5-methyl C

<400>  15
catcctggtc tgtgttcc                                                     18


<210>  16
<211>  18
<212>  DNA
<213>  artificial

<220>
<223>  LNA antisense gapmer oligonucleotide conjugate


<220>
<221>  misc_feature
<222>  (1)..(1)
<223>  Cholesterol-C6

<220>
<221>  misc_feature
<222>  (1)..(2)
<223>  phosphodiester lnternucleoside linkages

<220>
<221>  misc_feature
<222>  (3)..(18)
<223>  phosphorothioate lnternucleoside linkages

<220>
<221>  misc_feature
<222>  (3)..(5)
<223>  LNA nucleosides, LNA C are 5-methyl C

<220>
<221>  misc_feature
<222>  (17)..(18)
<223>  LNA nucleosides, LNA C are 5-methyl C

<400>  16
catcctggtc tgtgttcc                                                     18


<210>  17
<211>  14
<212>  DNA
<213>  ARTIFICIAL

<220>
<223>  LNA antisense gapmer oligonucleotide conjugate


<220>
<221>  misc_feature
<222>  (1)..(1)
<223>  GalNAc Conj2a

<220>
<221>  misc_feature
<222>  (1)..(14)
<223>  phosphorothioate lnternucleoside linkages

<220>
<221>  misc_feature
<222>  (1)..(3)
<223>  LNA nucleosides, LNA C are 5-methyl C

<220>
<221>  misc_feature
<222>  (12)..(14)
<223>  LNA nucleosides, LNA C are 5-methyl C

<400>  17
tgctacaaaa ccca                                                         14


<210>  18
<211>  16
<212>  DNA
<213>  ARTIFICIAL

<220>
<223>  LNA antisense gapmer oligonucleotide conjugate


<220>
<221>  misc_feature
<222>  (1)..(1)
<223>  GalNAc Conj2a

<220>
<221>  misc_feature
<222>  (1)..(16)
<223>  phosphorothioate lnternucleoside linkages

<220>
<221>  misc_feature
<222>  (1)..(3)
<223>  LNA nucleosides

<220>
<221>  misc_feature
<222>  (13)..(16)
<223>  LNA nucleosides, LNA C are 5-methyl C

<400>  18
aatgctacaa aaccca                                                       16


<210>  19
<211>  16
<212>  DNA
<213>  ARTIFICIAL

<220>
<223>  LNA antisense gapmer oligonucleotide conjugate


<220>
<221>  misc_feature
<222>  (1)..(1)
<223>  GalNAc Conj2a

<220>
<221>  misc_feature
<222>  (1)..(16)
<223>  phosphorothioate lnternucleoside linkages

<220>
<221>  misc_feature
<222>  (1)..(3)
<223>  LNA nucleosides

<220>
<221>  misc_feature
<222>  (14)..(16)
<223>  LNA nucleosides, LNA C are 5-methyl C

<400>  19
aatgctacaa aaccca                                                       16


<210>  20
<211>  15
<212>  DNA
<213>  ARTIFICIAL

<220>
<223>  LNA antisense gapmer oligonucleotide conjugate


<220>
<221>  misc_feature
<222>  (1)..(1)
<223>  GalNAc Conj2a

<220>
<221>  misc_feature
<222>  (1)..(15)
<223>  phosphorothioate lnternucleoside linkages

<220>
<221>  misc_feature
<222>  (1)..(2)
<223>  LNA nucleosides, LNA C are 5-methyl C

<220>
<221>  misc_feature
<222>  (14)..(15)
<223>  LNA nucleosides

<400>  20
gctgtgtgag cttgg                                                        15


<210>  21
<211>  16
<212>  DNA
<213>  ARTIFICIAL

<220>
<223>  LNA antisense gapmer oligonucleotide conjugate


<220>
<221>  misc_feature
<222>  (1)..(1)
<223>  GalNAc Conj2a

<220>
<221>  misc_feature
<222>  (1)..(2)
<223>  LNA nucleosides

<220>
<221>  misc_feature
<222>  (1)..(16)
<223>  phosphorothioate lnternucleoside linkages

<220>
<221>  misc_feature
<222>  (14)..(16)
<223>  LNA nucleosides

<400>  21
tgctgtgtga gcttgg                                                       16


<210>  22
<211>  16
<212>  DNA
<213>  ARTIFICIAL

<220>
<223>  LNA antisense gapmer oligonucleotide conjugate


<220>
<221>  misc_feature
<222>  (1)..(1)
<223>  GalNAc Conj2a

<220>
<221>  misc_feature
<222>  (1)..(16)
<223>  phosphorothioate lnternucleoside linkages

<220>
<221>  misc_feature
<222>  (1)..(3)
<223>  LNA nucleosides, LNA C are 5-methyl C

<220>
<221>  misc_feature
<222>  (14)..(16)
<223>  LNA nucleosides

<400>  22
tgctgtgtga gcttgg                                                       16


<210>  23
<211>  16
<212>  DNA
<213>  ARTIFICIAL

<220>
<223>  LNA antisense gapmer oligonucleotide conjugate


<220>
<221>  misc_feature
<222>  (1)..(1)
<223>  GalNAc Conj2a

<220>
<221>  misc_feature
<222>  (1)..(16)
<223>  phosphorothioate lnternucleoside linkages

<220>
<221>  misc_feature
<222>  (1)..(3)
<223>  LNA nucleosides, LNA C are 5-methyl C

<220>
<221>  misc_feature
<222>  (14)..(16)
<223>  LNA nucleosides, LNA C are 5-methyl C

<400>  23
tcctggtctg tgttcc                                                       16


<210>  24
<211>  16
<212>  DNA
<213>  artificial

<220>
<223>  LNA antisense gapmer oligonucleotide conjugate


<220>
<221>  misc_feature
<222>  (1)..(1)
<223>  GalNAc Conj2a

<220>
<221>  misc_feature
<222>  (1)..(16)
<223>  phosphorothioate lnternucleoside linkages

<220>
<221>  misc_feature
<222>  (1)..(3)
<223>  LNA nucleosides, LNA C are 5-methyl C

<220>
<221>  misc_feature
<222>  (15)..(16)
<223>  LNA nucleosides, LNA C are 5-methyl C

<400>  24
tcctggtctg tgttcc                                                       16


<210>  25
<211>  14
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  nucleobase sequence motif

<400>  25
tgctacaaaa ccca                                                         14


<210>  26
<211>  16
<212>  DNA
<213>  ARTIFICIAL

<220>
<223>  nucleobase sequence motif

<400>  26
aatgctacaa aaccca                                                       16


<210>  27
<211>  15
<212>  DNA
<213>  ARTIFICIAL

<220>
<223>  nucleobase sequence motif

<400>  27
gctgtgtgag cttgg                                                        15


<210>  28
<211>  16
<212>  DNA
<213>  ARTIFICIAL

<220>
<223>  nucleobase sequence motif

<400>  28
tgctgtgtga gcttgg                                                       16


<210>  29
<211>  16
<212>  DNA
<213>  ARTIFICIAL

<220>
<223>  nucleobase sequence motif

<400>  29
tcctggtctg tgttcc                                                       16


<210>  30
<211>  14
<212>  RNA
<213>  Homo sapiens

<400>  30
uggguuuugu agca                                                         14


<210>  31
<211>  16
<212>  RNA
<213>  Homo sapiens

<400>  31
uggguuuugu agcauu                                                       16


<210>  32
<211>  15
<212>  RNA
<213>  Homo sapiens

<400>  32
ccaagcucac acagc                                                        15


<210>  33
<211>  16
<212>  RNA
<213>  Homo sapiens

<400>  33
ccaagcucac acagca                                                       16


<210>  34
<211>  16
<212>  RNA
<213>  Homo sapiens

<400>  34
ggaacacaga ccagga                                                       16


<210>  35
<211>  16
<212>  DNA
<213>  artificial

<220>
<223>  LNA antisense gapmer oligonucleotide conjugate


<220>
<221>  misc_feature
<222>  (1)..(3)
<223>  phosphodiester lnternucleoside linkages

<220>
<221>  misc_feature
<222>  (1)..(1)
<223>  FAM conjugate

<220>
<221>  misc_feature
<222>  (4)..(16)
<223>  phosphorothioate lnternucleoside linkages

<220>
<221>  misc_feature
<222>  (4)..(5)
<223>  LNA nucleosides, LNA C are 5-methyl C

<220>
<221>  misc_feature
<222>  (14)..(16)
<223>  LNA nucleosides, LNA C are 5-methyl C

<400>  35
tcagcattgg tattca                                                       16


<210>  36
<211>  15
<212>  DNA
<213>  artificial

<220>
<223>  LNA antisense gapmer oligonucleotide conjugate


<220>
<221>  misc_feature
<222>  (1)..(2)
<223>  phosphodiester lnternucleoside linkages

<220>
<221>  misc_feature
<222>  (1)..(1)
<223>  FAM conjugate

<220>
<221>  misc_feature
<222>  (3)..(15)
<223>  phosphorothioate lnternucleoside linkages

<220>
<221>  misc_feature
<222>  (3)..(4)
<223>  LNA nucleosides, LNA C are 5-methyl C

<220>
<221>  misc_feature
<222>  (13)..(15)
<223>  LNA nucleosides, LNA C are 5-methyl C

<400>  36
cagcattggt attca                                                        15


<210>  37
<211>  14
<212>  DNA
<213>  artificial

<220>
<223>  LNA antisense gapmer oligonucleotide conjugate


<220>
<221>  misc_feature
<222>  (1)..(1)
<223>  phosphodiester lnternucleoside linkages

<220>
<221>  misc_feature
<222>  (1)..(1)
<223>  FAM conjugate

<220>
<221>  misc_feature
<222>  (2)..(14)
<223>  phosphorothioate lnternucleoside linkages

<220>
<221>  misc_feature
<222>  (2)..(3)
<223>  LNA nucleosides, LNA C are 5-methyl C

<220>
<221>  misc_feature
<222>  (12)..(14)
<223>  LNA nucleosides, LNA C are 5-methyl C

<400>  37
agcattggta ttca                                                         14


<210>  38
<211>  16
<212>  DNA
<213>  artificial

<220>
<223>  LNA antisense gapmer oligonucleotide conjugate


<220>
<221>  misc_feature
<222>  (1)..(3)
<223>  phosphodiester lnternucleoside linkages

<220>
<221>  misc_feature
<222>  (1)..(1)
<223>  FAM conjugate

<220>
<221>  misc_feature
<222>  (4)..(16)
<223>  phosphorothioate lnternucleoside linkages

<220>
<221>  misc_feature
<222>  (4)..(5)
<223>  LNA nucleosides, LNA C are 5-methyl C

<220>
<221>  misc_feature
<222>  (14)..(16)
<223>  LNA nucleosides, LNA C are 5-methyl C

<400>  38
gacgcattgg tattca                                                       16


<210>  39
<211>  13
<212>  DNA
<213>  artificial

<220>
<223>  LNA antisense gapmer oligonucleotide conjugate


<220>
<221>  misc_feature
<222>  (1)..(13)
<223>  phosphorothioate lnternucleoside linkages

<220>
<221>  misc_feature
<222>  (1)..(2)
<223>  LNA nucleosides, LNA C are 5-methyl C

<220>
<221>  misc_feature
<222>  (1)..(1)
<223>  FAM conjugate

<220>
<221>  misc_feature
<222>  (11)..(13)
<223>  LNA nucleosides, LNA C are 5-methyl C

<400>  39
gcattggtat tca                                                          13


<210>  40
<211>  13
<212>  DNA
<213>  artificial

<220>
<223>  LNA antisense gapmer oligonucleotide


<220>
<221>  misc_feature
<222>  (1)..(13)
<223>  phosphorothioate lnternucleoside linkages

<220>
<221>  misc_feature
<222>  (1)..(2)
<223>  LNA nucleosides

<220>
<221>  misc_feature
<222>  (11)..(13)
<223>  LNA nucleosides, LNA C are 5-methyl C

<400>  40
gtctgtggaa gcg                                                          13


<210>  41
<211>  13
<212>  DNA
<213>  artificial

<220>
<223>  LNA antisense gapmer oligonucleotide conjugate


<220>
<221>  misc_feature
<222>  (1)..(1)
<223>  Cholesterol-C6

<220>
<221>  misc_feature
<222>  (1)..(13)
<223>  phosphorothioate lnternucleoside linkages

<220>
<221>  misc_feature
<222>  (1)..(2)
<223>  LNA nucleosides

<220>
<221>  misc_feature
<222>  (11)..(13)
<223>  LNA nucleosides, LNA C are 5-methyl C

<400>  41
gtctgtggaa gcg                                                          13


<210>  42
<211>  15
<212>  DNA
<213>  artificial

<220>
<223>  LNA antisense gapmer oligonucleotide conjugate


<220>
<221>  misc_feature
<222>  (1)..(1)
<223>  Cholesterol-C6

<220>
<221>  misc_feature
<222>  (1)..(2)
<223>  phosphodiester lnternucleoside linkages

<220>
<221>  misc_feature
<222>  (3)..(4)
<223>  LNA nucleosides

<220>
<221>  misc_feature
<222>  (3)..(15)
<223>  phosphorothioate lnternucleoside linkages

<220>
<221>  misc_feature
<222>  (13)..(15)
<223>  LNA nucleosides, LNA C are 5-methyl C

<400>  42
cagtctgtgg aagcg                                                        15


<210>  43
<211>  15
<212>  DNA
<213>  artificial

<220>
<223>  LNA antisense gapmer oligonucleotide conjugate


<220>
<221>  misc_feature
<222>  (1)..(1)
<223>  Cholesterol-C6

<220>
<221>  misc_feature
<222>  (1)..(2)
<223>  phosphodiester lnternucleoside linkages

<220>
<221>  misc_feature
<222>  (3)..(4)
<223>  LNA nucleosides

<220>
<221>  misc_feature
<222>  (3)..(15)
<223>  phosphorothioate lnternucleoside linkages

<220>
<221>  misc_feature
<222>  (13)..(15)
<223>  LNA nucleosides, LNA C are 5-methyl C

<400>  43
ctgtctgtgg aagcg                                                        15


<210>  44
<211>  13
<212>  DNA
<213>  artificial

<220>
<223>  nucleobase sequence motif

<400>  44
gtctgtggaa gcg                                                          13


<210>  45
<211>  13
<212>  RNA
<213>  Homo sapiens

<400>  45
cgcuuccaca gac                                                          13


<210>  46
<211>  3731
<212>  DNA
<213>  homo sapiens

<400>  46
gtccgatggg gctctggtgg cgtgatctgc gcgccccagg cgtcaagcac ccacacccta       60

gaaggtttcc gcagcgacgt cgaggcgctc atggttgcag gcgggcgccg ccgttcagtt      120

cagggtctga gcctggagga gtgagccagg cagtgagact ggctcgggcg ggccgggacg      180

cgtcgttgca gcagcggctc ccagctccca gccaggattc cgcgcgcccc ttcacgcgcc      240

ctgctcctga acttcagctc ctgcacagtc ctccccaccg caaggctcaa ggcgccgccg      300

gcgtggaccg cgcacggcct ctaggtctcc tcgccaggac agcaacctct cccctggccc      360

tcatgggcac cgtcagctcc aggcggtcct ggtggccgct gccactgctg ctgctgctgc      420

tgctgctcct gggtcccgcg ggcgcccgtg cgcaggagga cgaggacggc gactacgagg      480

agctggtgct agccttgcgt tccgaggagg acggcctggc cgaagcaccc gagcacggaa      540

ccacagccac cttccaccgc tgcgccaagg atccgtggag gttgcctggc acctacgtgg      600

tggtgctgaa ggaggagacc cacctctcgc agtcagagcg cactgcccgc cgcctgcagg      660

cccaggctgc ccgccgggga tacctcacca agatcctgca tgtcttccat ggccttcttc      720

ctggcttcct ggtgaagatg agtggcgacc tgctggagct ggccttgaag ttgccccatg      780

tcgactacat cgaggaggac tcctctgtct ttgcccagag catcccgtgg aacctggagc      840

ggattacccc tccacggtac cgggcggatg aataccagcc ccccgacgga ggcagcctgg      900

tggaggtgta tctcctagac accagcatac agagtgacca ccgggaaatc gagggcaggg      960

tcatggtcac cgacttcgag aatgtgcccg aggaggacgg gacccgcttc cacagacagg     1020

ccagcaagtg tgacagtcat ggcacccacc tggcaggggt ggtcagcggc cgggatgccg     1080

gcgtggccaa gggtgccagc atgcgcagcc tgcgcgtgct caactgccaa gggaagggca     1140

cggttagcgg caccctcata ggcctggagt ttattcggaa aagccagctg gtccagcctg     1200

tggggccact ggtggtgctg ctgcccctgg cgggtgggta cagccgcgtc ctcaacgccg     1260

cctgccagcg cctggcgagg gctggggtcg tgctggtcac cgctgccggc aacttccggg     1320

acgatgcctg cctctactcc ccagcctcag ctcccgaggt catcacagtt ggggccacca     1380

atgcccaaga ccagccggtg accctgggga ctttggggac caactttggc cgctgtgtgg     1440

acctctttgc cccaggggag gacatcattg gtgcctccag cgactgcagc acctgctttg     1500

tgtcacagag tgggacatca caggctgctg cccacgtggc tggcattgca gccatgatgc     1560

tgtctgccga gccggagctc accctggccg agttgaggca gagactgatc cacttctctg     1620

ccaaagatgt catcaatgag gcctggttcc ctgaggacca gcgggtactg acccccaacc     1680

tggtggccgc cctgcccccc agcacccatg gggcaggttg gcagctgttt tgcaggactg     1740

tatggtcagc acactcgggg cctacacgga tggccacagc cgtcgcccgc tgcgccccag     1800

atgaggagct gctgagctgc tccagtttct ccaggagtgg gaagcggcgg ggcgagcgca     1860

tggaggccca agggggcaag ctggtctgcc gggcccacaa cgcttttggg ggtgagggtg     1920

tctacgccat tgccaggtgc tgcctgctac cccaggccaa ctgcagcgtc cacacagctc     1980

caccagctga ggccagcatg gggacccgtg tccactgcca ccaacagggc cacgtcctca     2040

caggctgcag ctcccactgg gaggtggagg accttggcac ccacaagccg cctgtgctga     2100

ggccacgagg tcagcccaac cagtgcgtgg gccacaggga ggccagcatc cacgcttcct     2160

gctgccatgc cccaggtctg gaatgcaaag tcaaggagca tggaatcccg gcccctcagg     2220

agcaggtgac cgtggcctgc gaggagggct ggaccctgac tggctgcagt gccctccctg     2280

ggacctccca cgtcctgggg gcctacgccg tagacaacac gtgtgtagtc aggagccggg     2340

acgtcagcac tacaggcagc accagcgaag gggccgtgac agccgttgcc atctgctgcc     2400

ggagccggca cctggcgcag gcctcccagg agctccagtg acagccccat cccaggatgg     2460

gtgtctgggg agggtcaagg gctggggctg agctttaaaa tggttccgac ttgtccctct     2520

ctcagccctc catggcctgg cacgagggga tggggatgct tccgcctttc cggggctgct     2580

ggcctggccc ttgagtgggg cagcctcctt gcctggaact cactcactct gggtgcctcc     2640

tccccaggtg gaggtgccag gaagctccct ccctcactgt ggggcatttc accattcaaa     2700

caggtcgagc tgtgctcggg tgctgccagc tgctcccaat gtgccgatgt ccgtgggcag     2760

aatgactttt attgagctct tgttccgtgc caggcattca atcctcaggt ctccaccaag     2820

gaggcaggat tcttcccatg gataggggag ggggcggtag gggctgcagg gacaaacatc     2880

gttggggggt gagtgtgaaa ggtgctgatg gccctcatct ccagctaact gtggagaagc     2940

ccctgggggc tccctgatta atggaggctt agctttctgg atggcatcta gccagaggct     3000

ggagacaggt gcgcccctgg tggtcacagg ctgtgccttg gtttcctgag ccacctttac     3060

tctgctctat gccaggctgt gctagcaaca cccaaaggtg gcctgcgggg agccatcacc     3120

taggactgac tcggcagtgt gcagtggtgc atgcactgtc tcagccaacc cgctccacta     3180

cccggcaggg tacacattcg cacccctact tcacagagga agaaacctgg aaccagaggg     3240

ggcgtgcctg ccaagctcac acagcaggaa ctgagccaga aacgcagatt gggctggctc     3300

tgaagccaag cctcttctta cttcacccgg ctgggctcct catttttacg ggtaacagtg     3360

aggctgggaa ggggaacaca gaccaggaag ctcggtgagt gatggcagaa cgatgcctgc     3420

aggcatggaa ctttttccgt tatcacccag gcctgattca ctggcctggc ggagatgctt     3480

ctaaggcatg gtcgggggag agggccaaca actgtccctc cttgagcacc agccccaccc     3540

aagcaagcag acatttatct tttgggtctg tcctctctgt tgccttttta cagccaactt     3600

ttctagacct gttttgcttt tgtaacttga agatatttat tctgggtttt gtagcatttt     3660

tattaatatg gtgacttttt aaaataaaaa caaacaaacg ttgtcctaac aaaaaaaaaa     3720

aaaaaaaaaa a                                                          3731


