                         SEQUENCE LISTING

<110>  Abengoa Bioenergia Nuevas Tecnologias S.A.
 
<120>  Yeast engineered for the production of 1-alcohols from sugars 
       under anoxic conditions

<130>  P6044096PCT

<150>  EP13382243.7
<151>  2013-06-26

<160>  80    

<170>  PatentIn version 3.3

<210>  1
<211>  563
<212>  PRT
<213>  Saccharomyces cerevisiae


<220>
<221>  MISC_FEATURE
<223>  S. cerevisiae PDC1 (Accession No. NP_013145)

<400>  1

Met Ser Glu Ile Thr Leu Gly Lys Tyr Leu Phe Glu Arg Leu Lys Gln 
1               5                   10                  15      


Val Asn Val Asn Thr Val Phe Gly Leu Pro Gly Asp Phe Asn Leu Ser 
            20                  25                  30          


Leu Leu Asp Lys Ile Tyr Glu Val Glu Gly Met Arg Trp Ala Gly Asn 
        35                  40                  45              


Ala Asn Glu Leu Asn Ala Ala Tyr Ala Ala Asp Gly Tyr Ala Arg Ile 
    50                  55                  60                  


Lys Gly Met Ser Cys Ile Ile Thr Thr Phe Gly Val Gly Glu Leu Ser 
65                  70                  75                  80  


Ala Leu Asn Gly Ile Ala Gly Ser Tyr Ala Glu His Val Gly Val Leu 
                85                  90                  95      


His Val Val Gly Val Pro Ser Ile Ser Ala Gln Ala Lys Gln Leu Leu 
            100                 105                 110         


Leu His His Thr Leu Gly Asn Gly Asp Phe Thr Val Phe His Arg Met 
        115                 120                 125             


Ser Ala Asn Ile Ser Glu Thr Thr Ala Met Ile Thr Asp Ile Ala Thr 
    130                 135                 140                 


Ala Pro Ala Glu Ile Asp Arg Cys Ile Arg Thr Thr Tyr Val Thr Gln 
145                 150                 155                 160 


Arg Pro Val Tyr Leu Gly Leu Pro Ala Asn Leu Val Asp Leu Asn Val 
                165                 170                 175     


Pro Ala Lys Leu Leu Gln Thr Pro Ile Asp Met Ser Leu Lys Pro Asn 
            180                 185                 190         


Asp Ala Glu Ser Glu Lys Glu Val Ile Asp Thr Ile Leu Ala Leu Val 
        195                 200                 205             


Lys Asp Ala Lys Asn Pro Val Ile Leu Ala Asp Ala Cys Cys Ser Arg 
    210                 215                 220                 


His Asp Val Lys Ala Glu Thr Lys Lys Leu Ile Asp Leu Thr Gln Phe 
225                 230                 235                 240 


Pro Ala Phe Val Thr Pro Met Gly Lys Gly Ser Ile Asp Glu Gln His 
                245                 250                 255     


Pro Arg Tyr Gly Gly Val Tyr Val Gly Thr Leu Ser Lys Pro Glu Val 
            260                 265                 270         


Lys Glu Ala Val Glu Ser Ala Asp Leu Ile Leu Ser Val Gly Ala Leu 
        275                 280                 285             


Leu Ser Asp Phe Asn Thr Gly Ser Phe Ser Tyr Ser Tyr Lys Thr Lys 
    290                 295                 300                 


Asn Ile Val Glu Phe His Ser Asp His Met Lys Ile Arg Asn Ala Thr 
305                 310                 315                 320 


Phe Pro Gly Val Gln Met Lys Phe Val Leu Gln Lys Leu Leu Thr Thr 
                325                 330                 335     


Ile Ala Asp Ala Ala Lys Gly Tyr Lys Pro Val Ala Val Pro Ala Arg 
            340                 345                 350         


Thr Pro Ala Asn Ala Ala Val Pro Ala Ser Thr Pro Leu Lys Gln Glu 
        355                 360                 365             


Trp Met Trp Asn Gln Leu Gly Asn Phe Leu Gln Glu Gly Asp Val Val 
    370                 375                 380                 


Ile Ala Glu Thr Gly Thr Ser Ala Phe Gly Ile Asn Gln Thr Thr Phe 
385                 390                 395                 400 


Pro Asn Asn Thr Tyr Gly Ile Ser Gln Val Leu Trp Gly Ser Ile Gly 
                405                 410                 415     


Phe Thr Thr Gly Ala Thr Leu Gly Ala Ala Phe Ala Ala Glu Glu Ile 
            420                 425                 430         


Asp Pro Lys Lys Arg Val Ile Leu Phe Ile Gly Asp Gly Ser Leu Gln 
        435                 440                 445             


Leu Thr Val Gln Glu Ile Ser Thr Met Ile Arg Trp Gly Leu Lys Pro 
    450                 455                 460                 


Tyr Leu Phe Val Leu Asn Asn Asp Gly Tyr Thr Ile Glu Lys Leu Ile 
465                 470                 475                 480 


His Gly Pro Lys Ala Gln Tyr Asn Glu Ile Gln Gly Trp Asp His Leu 
                485                 490                 495     


Ser Leu Leu Pro Thr Phe Gly Ala Lys Asp Tyr Glu Thr His Arg Val 
            500                 505                 510         


Ala Thr Thr Gly Glu Trp Asp Lys Leu Thr Gln Asp Lys Ser Phe Asn 
        515                 520                 525             


Asp Asn Ser Lys Ile Arg Met Ile Glu Ile Met Leu Pro Val Phe Asp 
    530                 535                 540                 


Ala Pro Gln Asn Leu Val Glu Gln Ala Lys Leu Thr Ala Ala Thr Asn 
545                 550                 555                 560 


Ala Lys Gln 
            


<210>  2
<211>  563
<212>  PRT
<213>  Saccharomyces cerevisiae


<220>
<221>  MISC_FEATURE
<223>  S. cerevisiae PDC5 (Accession No. NP_013235)

<400>  2

Met Ser Glu Ile Thr Leu Gly Lys Tyr Leu Phe Glu Arg Leu Ser Gln 
1               5                   10                  15      


Val Asn Cys Asn Thr Val Phe Gly Leu Pro Gly Asp Phe Asn Leu Ser 
            20                  25                  30          


Leu Leu Asp Lys Leu Tyr Glu Val Lys Gly Met Arg Trp Ala Gly Asn 
        35                  40                  45              


Ala Asn Glu Leu Asn Ala Ala Tyr Ala Ala Asp Gly Tyr Ala Arg Ile 
    50                  55                  60                  


Lys Gly Met Ser Cys Ile Ile Thr Thr Phe Gly Val Gly Glu Leu Ser 
65                  70                  75                  80  


Ala Leu Asn Gly Ile Ala Gly Ser Tyr Ala Glu His Val Gly Val Leu 
                85                  90                  95      


His Val Val Gly Val Pro Ser Ile Ser Ser Gln Ala Lys Gln Leu Leu 
            100                 105                 110         


Leu His His Thr Leu Gly Asn Gly Asp Phe Thr Val Phe His Arg Met 
        115                 120                 125             


Ser Ala Asn Ile Ser Glu Thr Thr Ala Met Ile Thr Asp Ile Ala Asn 
    130                 135                 140                 


Ala Pro Ala Glu Ile Asp Arg Cys Ile Arg Thr Thr Tyr Thr Thr Gln 
145                 150                 155                 160 


Arg Pro Val Tyr Leu Gly Leu Pro Ala Asn Leu Val Asp Leu Asn Val 
                165                 170                 175     


Pro Ala Lys Leu Leu Glu Thr Pro Ile Asp Leu Ser Leu Lys Pro Asn 
            180                 185                 190         


Asp Ala Glu Ala Glu Ala Glu Val Val Arg Thr Val Val Glu Leu Ile 
        195                 200                 205             


Lys Asp Ala Lys Asn Pro Val Ile Leu Ala Asp Ala Cys Ala Ser Arg 
    210                 215                 220                 


His Asp Val Lys Ala Glu Thr Lys Lys Leu Met Asp Leu Thr Gln Phe 
225                 230                 235                 240 


Pro Val Tyr Val Thr Pro Met Gly Lys Gly Ala Ile Asp Glu Gln His 
                245                 250                 255     


Pro Arg Tyr Gly Gly Val Tyr Val Gly Thr Leu Ser Arg Pro Glu Val 
            260                 265                 270         


Lys Lys Ala Val Glu Ser Ala Asp Leu Ile Leu Ser Ile Gly Ala Leu 
        275                 280                 285             


Leu Ser Asp Phe Asn Thr Gly Ser Phe Ser Tyr Ser Tyr Lys Thr Lys 
    290                 295                 300                 


Asn Ile Val Glu Phe His Ser Asp His Ile Lys Ile Arg Asn Ala Thr 
305                 310                 315                 320 


Phe Pro Gly Val Gln Met Lys Phe Ala Leu Gln Lys Leu Leu Asp Ala 
                325                 330                 335     


Ile Pro Glu Val Val Lys Asp Tyr Lys Pro Val Ala Val Pro Ala Arg 
            340                 345                 350         


Val Pro Ile Thr Lys Ser Thr Pro Ala Asn Thr Pro Met Lys Gln Glu 
        355                 360                 365             


Trp Met Trp Asn His Leu Gly Asn Phe Leu Arg Glu Gly Asp Ile Val 
    370                 375                 380                 


Ile Ala Glu Thr Gly Thr Ser Ala Phe Gly Ile Asn Gln Thr Thr Phe 
385                 390                 395                 400 


Pro Thr Asp Val Tyr Ala Ile Val Gln Val Leu Trp Gly Ser Ile Gly 
                405                 410                 415     


Phe Thr Val Gly Ala Leu Leu Gly Ala Thr Met Ala Ala Glu Glu Leu 
            420                 425                 430         


Asp Pro Lys Lys Arg Val Ile Leu Phe Ile Gly Asp Gly Ser Leu Gln 
        435                 440                 445             


Leu Thr Val Gln Glu Ile Ser Thr Met Ile Arg Trp Gly Leu Lys Pro 
    450                 455                 460                 


Tyr Ile Phe Val Leu Asn Asn Asn Gly Tyr Thr Ile Glu Lys Leu Ile 
465                 470                 475                 480 


His Gly Pro His Ala Glu Tyr Asn Glu Ile Gln Gly Trp Asp His Leu 
                485                 490                 495     


Ala Leu Leu Pro Thr Phe Gly Ala Arg Asn Tyr Glu Thr His Arg Val 
            500                 505                 510         


Ala Thr Thr Gly Glu Trp Glu Lys Leu Thr Gln Asp Lys Asp Phe Gln 
        515                 520                 525             


Asp Asn Ser Lys Ile Arg Met Ile Glu Val Met Leu Pro Val Phe Asp 
    530                 535                 540                 


Ala Pro Gln Asn Leu Val Lys Gln Ala Gln Leu Thr Ala Ala Thr Asn 
545                 550                 555                 560 


Ala Lys Gln 
            


<210>  3
<211>  563
<212>  PRT
<213>  Saccharomyces cerevisiae


<220>
<221>  MISC_FEATURE
<223>  S. cerevisiae PDC6 (Accession No. NP_011601)

<400>  3

Met Ser Glu Ile Thr Leu Gly Lys Tyr Leu Phe Glu Arg Leu Lys Gln 
1               5                   10                  15      


Val Asn Val Asn Thr Ile Phe Gly Leu Pro Gly Asp Phe Asn Leu Ser 
            20                  25                  30          


Leu Leu Asp Lys Ile Tyr Glu Val Asp Gly Leu Arg Trp Ala Gly Asn 
        35                  40                  45              


Ala Asn Glu Leu Asn Ala Ala Tyr Ala Ala Asp Gly Tyr Ala Arg Ile 
    50                  55                  60                  


Lys Gly Leu Ser Val Leu Val Thr Thr Phe Gly Val Gly Glu Leu Ser 
65                  70                  75                  80  


Ala Leu Asn Gly Ile Ala Gly Ser Tyr Ala Glu His Val Gly Val Leu 
                85                  90                  95      


His Val Val Gly Val Pro Ser Ile Ser Ala Gln Ala Lys Gln Leu Leu 
            100                 105                 110         


Leu His His Thr Leu Gly Asn Gly Asp Phe Thr Val Phe His Arg Met 
        115                 120                 125             


Ser Ala Asn Ile Ser Glu Thr Thr Ser Met Ile Thr Asp Ile Ala Thr 
    130                 135                 140                 


Ala Pro Ser Glu Ile Asp Arg Leu Ile Arg Thr Thr Phe Ile Thr Gln 
145                 150                 155                 160 


Arg Pro Ser Tyr Leu Gly Leu Pro Ala Asn Leu Val Asp Leu Lys Val 
                165                 170                 175     


Pro Gly Ser Leu Leu Glu Lys Pro Ile Asp Leu Ser Leu Lys Pro Asn 
            180                 185                 190         


Asp Pro Glu Ala Glu Lys Glu Val Ile Asp Thr Val Leu Glu Leu Ile 
        195                 200                 205             


Gln Asn Ser Lys Asn Pro Val Ile Leu Ser Asp Ala Cys Ala Ser Arg 
    210                 215                 220                 


His Asn Val Lys Lys Glu Thr Gln Lys Leu Ile Asp Leu Thr Gln Phe 
225                 230                 235                 240 


Pro Ala Phe Val Thr Pro Leu Gly Lys Gly Ser Ile Asp Glu Gln His 
                245                 250                 255     


Pro Arg Tyr Gly Gly Val Tyr Val Gly Thr Leu Ser Lys Gln Asp Val 
            260                 265                 270         


Lys Gln Ala Val Glu Ser Ala Asp Leu Ile Leu Ser Val Gly Ala Leu 
        275                 280                 285             


Leu Ser Asp Phe Asn Thr Gly Ser Phe Ser Tyr Ser Tyr Lys Thr Lys 
    290                 295                 300                 


Asn Val Val Glu Phe His Ser Asp Tyr Val Lys Val Lys Asn Ala Thr 
305                 310                 315                 320 


Phe Leu Gly Val Gln Met Lys Phe Ala Leu Gln Asn Leu Leu Lys Val 
                325                 330                 335     


Ile Pro Asp Val Val Lys Gly Tyr Lys Ser Val Pro Val Pro Thr Lys 
            340                 345                 350         


Thr Pro Ala Asn Lys Gly Val Pro Ala Ser Thr Pro Leu Lys Gln Glu 
        355                 360                 365             


Trp Leu Trp Asn Glu Leu Ser Lys Phe Leu Gln Glu Gly Asp Val Ile 
    370                 375                 380                 


Ile Ser Glu Thr Gly Thr Ser Ala Phe Gly Ile Asn Gln Thr Ile Phe 
385                 390                 395                 400 


Pro Lys Asp Ala Tyr Gly Ile Ser Gln Val Leu Trp Gly Ser Ile Gly 
                405                 410                 415     


Phe Thr Thr Gly Ala Thr Leu Gly Ala Ala Phe Ala Ala Glu Glu Ile 
            420                 425                 430         


Asp Pro Asn Lys Arg Val Ile Leu Phe Ile Gly Asp Gly Ser Leu Gln 
        435                 440                 445             


Leu Thr Val Gln Glu Ile Ser Thr Met Ile Arg Trp Gly Leu Lys Pro 
    450                 455                 460                 


Tyr Leu Phe Val Leu Asn Asn Asp Gly Tyr Thr Ile Glu Lys Leu Ile 
465                 470                 475                 480 


His Gly Pro His Ala Glu Tyr Asn Glu Ile Gln Thr Trp Asp His Leu 
                485                 490                 495     


Ala Leu Leu Pro Ala Phe Gly Ala Lys Lys Tyr Glu Asn His Lys Ile 
            500                 505                 510         


Ala Thr Thr Gly Glu Trp Asp Ala Leu Thr Thr Asp Ser Glu Phe Gln 
        515                 520                 525             


Lys Asn Ser Val Ile Arg Leu Ile Glu Leu Lys Leu Pro Val Phe Asp 
    530                 535                 540                 


Ala Pro Glu Ser Leu Ile Lys Gln Ala Gln Leu Thr Ala Ala Thr Asn 
545                 550                 555                 560 


Ala Lys Gln 
            


<210>  4
<211>  925
<212>  PRT
<213>  Saccharomyces cerevisiae


<220>
<221>  MISC_FEATURE
<223>  S. cerevisiae PDC2 (Accession No. NP_010366)

<400>  4

Met Leu Ser Ile Gln Gln Arg Tyr Asn Ile Cys Leu Met Ala Glu Arg 
1               5                   10                  15      


His Pro Lys Trp Thr Gln Leu Glu Leu Ala Lys Trp Ala Tyr Glu Thr 
            20                  25                  30          


Phe Gln Leu Pro Lys Ile Pro Ser Gln Gly Thr Ile Ser Arg Leu Leu 
        35                  40                  45              


Ala Arg Lys Ser Thr Tyr Met Asn Cys Lys Glu His Glu Lys Asp Ala 
    50                  55                  60                  


Asn Arg Leu Arg Lys Pro Asn Asn Leu Leu Val Arg Lys Ile Leu Gln 
65                  70                  75                  80  


Glu Trp Ile Ser Gln Ser Leu Trp Asn Gly Ile Pro Ile Thr Ser Pro 
                85                  90                  95      


Ile Ile Gln Asp Thr Ala Gln Ala Val Trp His Arg Ile Pro Ala Glu 
            100                 105                 110         


His Arg Glu Gly Asn Gly Ser Phe Ser Tyr Lys Trp Ile Ser Asn Phe 
        115                 120                 125             


Leu Ser Lys Met Asp Val Asn Ile Ser Val Leu Asp Glu Glu Leu Pro 
    130                 135                 140                 


Lys Thr Pro Lys Val Trp Thr Phe Glu Glu Arg Asp Val Leu Lys Ala 
145                 150                 155                 160 


Tyr Phe Ser Lys Ile Pro Pro Lys Asp Leu Phe Thr Leu Asp Glu Ala 
                165                 170                 175     


Phe Leu Ser Tyr Asn Leu Pro Leu Asp Tyr Ala Gln Tyr Glu Ala Ser 
            180                 185                 190         


Ser Ile Gln Arg Arg Ile Glu Val Ala Thr Val Met Leu Cys Ser Asn 
        195                 200                 205             


Leu Asp Gly Ser Glu Lys Leu Lys Pro Val Val Val Gly Lys Tyr Asp 
    210                 215                 220                 


Ser Tyr Lys Ser Phe Arg Asn Tyr Phe Pro Asn Glu Pro Asn Asp Pro 
225                 230                 235                 240 


Val Ser Gln Ser Met Leu Gly Thr Lys Met Ala Lys Lys Phe Asp Ile 
                245                 250                 255     


Ser Tyr His Ser Asn Arg Lys Ala Trp Leu Thr Ser Asn Leu Phe His 
            260                 265                 270         


Asn Trp Leu Val Arg Trp Asp Lys Arg Leu Val Ala Val Asn Arg Lys 
        275                 280                 285             


Ile Trp Ile Val Leu Asp Asp Ser Cys Cys His Arg Ile Ile Asn Leu 
    290                 295                 300                 


Arg Leu Gln Asn Ile Lys Leu Val Tyr Thr Ser Ser Asn Ser Lys Phe 
305                 310                 315                 320 


Leu Pro Phe Asn Trp Gly Val Trp Asp Glu Phe Lys Thr Arg Tyr Arg 
                325                 330                 335     


Ile Gln Gln Tyr Gln Ala Leu Ile Asp Leu Gln Asn Arg Ile Ser Lys 
            340                 345                 350         


Asn Ile Gln Asn Lys Asn Lys Ser Glu Arg Asn Glu Cys Ile Pro Asn 
        355                 360                 365             


Gly Lys Lys Cys Leu Ile Ser Phe Glu Gln Ser Gln Leu Thr Met Ser 
    370                 375                 380                 


Asn Ala Phe Lys Phe Ile Lys Lys Ala Trp Asp Asp Ile Pro Val Asp 
385                 390                 395                 400 


Ala Ile Lys Ala Asn Trp Lys Ser Ser Gly Leu Leu Pro Pro Glu Met 
                405                 410                 415     


Ile His Leu Asn Glu Asn Val Ser Met Ala Phe Lys Lys Asn Glu Val 
            420                 425                 430         


Leu Glu Ser Val Leu Asn Arg Leu Cys Asp Glu Tyr Tyr Cys Val Lys 
        435                 440                 445             


Lys Trp Glu Tyr Glu Met Leu Leu Asp Leu Asn Ile Glu Asn Lys Asn 
    450                 455                 460                 


Thr Asn Phe Leu Ser Thr Glu Glu Leu Val Glu Ser Ala Ile Val Glu 
465                 470                 475                 480 


Pro Cys Glu Pro Asp Phe Asp Thr Ala Pro Lys Gly Asn Glu Val His 
                485                 490                 495     


Asp Asp Asn Phe Asp Val Ser Val Phe Ala Asn Glu Asp Asp Asn Asn 
            500                 505                 510         


Gln Asn His Leu Ser Met Ser Gln Ala Ser His Asn Pro Asp Tyr Asn 
        515                 520                 525             


Ser Asn His Ser Asn Asn Ala Ile Glu Asn Thr Asn Asn Arg Gly Ser 
    530                 535                 540                 


Asn Asn Asn Asn Asn Asn Asn Gly Ser Ser Asn Asn Ile Asn Asp Asn 
545                 550                 555                 560 


Asp Ser Ser Val Lys Tyr Leu Gln Gln Asn Thr Val Asp Asn Ser Thr 
                565                 570                 575     


Lys Thr Gly Asn Pro Gly Gln Pro Asn Ile Ser Ser Met Glu Ser Gln 
            580                 585                 590         


Arg Asn Ser Ser Thr Thr Asp Leu Val Val Asp Gly Asn Tyr Asp Val 
        595                 600                 605             


Asn Phe Asn Gly Leu Leu Asn Asp Pro Tyr Asn Thr Met Lys Gln Pro 
    610                 615                 620                 


Gly Pro Leu Asp Tyr Asn Val Ser Thr Leu Ile Asp Lys Pro Asn Leu 
625                 630                 635                 640 


Phe Leu Ser Pro Asp Leu Asp Leu Ser Thr Val Gly Val Asp Met Gln 
                645                 650                 655     


Leu Pro Ser Ser Glu Tyr Phe Ser Glu Val Phe Ser Ser Ala Ile Arg 
            660                 665                 670         


Asn Asn Glu Lys Ala Ala Ser Asp Gln Asn Lys Ser Thr Asp Glu Leu 
        675                 680                 685             


Pro Ser Ser Thr Ala Met Ala Asn Ser Asn Ser Ile Thr Thr Ala Leu 
    690                 695                 700                 


Leu Glu Ser Arg Asn Gln Ala Gln Pro Phe Asp Val Pro His Met Asn 
705                 710                 715                 720 


Gly Leu Leu Ser Asp Thr Ser Lys Ser Gly His Ser Val Asn Ser Ser 
                725                 730                 735     


Asn Ala Ile Ser Gln Asn Ser Leu Asn Asn Phe Gln His Asn Ser Ala 
            740                 745                 750         


Ser Val Ala Glu Ala Ser Ser Pro Ser Ile Thr Pro Ser Pro Val Ala 
        755                 760                 765             


Ile Asn Ser Thr Gly Ala Pro Ala Arg Ser Ile Ile Ser Ala Pro Ile 
    770                 775                 780                 


Asp Ser Asn Ser Ser Ala Ser Ser Pro Ser Ala Leu Glu His Leu Glu 
785                 790                 795                 800 


Gly Ala Val Ser Gly Met Ser Pro Ser Ser Thr Thr Ile Leu Ser Asn 
                805                 810                 815     


Leu Gln Thr Asn Ile Asn Ile Ala Lys Ser Leu Ser Thr Ile Met Lys 
            820                 825                 830         


His Ala Glu Ser Asn Glu Ile Ser Leu Thr Lys Glu Thr Ile Asn Glu 
        835                 840                 845             


Leu Asn Phe Asn Tyr Leu Thr Leu Leu Lys Arg Ile Lys Lys Thr Arg 
    850                 855                 860                 


Lys Gln Leu Asn Ser Glu Ser Ile Lys Ile Asn Ser Lys Asn Ala Gln 
865                 870                 875                 880 


Asp His Leu Glu Thr Leu Leu Ser Gly Ala Ala Ala Ala Ala Ala Thr 
                885                 890                 895     


Ser Ala Asn Asn Leu Asp Leu Pro Thr Gly Gly Ser Asn Leu Pro Asp 
            900                 905                 910         


Ser Asn Asn Leu His Leu Pro Gly Asn Thr Gly Phe Phe 
        915                 920                 925 


<210>  5
<211>  433
<212>  PRT
<213>  Saccharomyces cerevisiae

<400>  5

Met Phe Val Ser Pro Pro Pro Ala Thr Ser Lys Asn Gln Val Leu Gln 
1               5                   10                  15      


Arg Arg Pro Leu Glu Ser Thr Asn Ser Asn His Gly Phe Ala Ser Ser 
            20                  25                  30          


Leu Gln Ala Ile Pro Glu Asn Thr Met Ser Gly Ser Asp Asn Ala Ser 
        35                  40                  45              


Phe Gln Ser Leu Pro Leu Ser Met Ser Ser Ser Gln Ser Thr Thr Ser 
    50                  55                  60                  


Ser Arg Arg Glu Asn Phe Val Asn Ala Pro Pro Glu Tyr Thr Asp Arg 
65                  70                  75                  80  


Ala Arg Asp Glu Ile Lys Lys Arg Leu Leu Ala Ser Ser Pro Ser Arg 
                85                  90                  95      


Arg Ser His His Ser Ser Ser Met His Ser Ala Ser Arg Arg Ser Ser 
            100                 105                 110         


Val Ala Glu Ser Gly Ser Leu Leu Ser Asp Asn Ala Ser Ser Tyr Gln 
        115                 120                 125             


Ser Ser Ile Phe Ser Ala Pro Ser Thr Val His Thr Gln Leu Thr Asn 
    130                 135                 140                 


Asp Ser Ser Phe Ser Glu Phe Pro Asn His Lys Leu Ile Thr Arg Val 
145                 150                 155                 160 


Ser Leu Asp Glu Ala Leu Pro Lys Thr Phe Tyr Asp Met Tyr Ser Pro 
                165                 170                 175     


Asp Ile Leu Leu Ala Asp Pro Ser Asn Ile Leu Cys Asn Gly Arg Pro 
            180                 185                 190         


Lys Phe Thr Lys Arg Glu Leu Leu Asp Trp Asp Leu Asn Asp Ile Arg 
        195                 200                 205             


Ser Leu Leu Ile Val Glu Lys Leu Arg Pro Glu Trp Gly Asn Gln Leu 
    210                 215                 220                 


Pro Glu Val Ile Thr Val Gly Asp Asn Met Pro Gln Phe Arg Leu Gln 
225                 230                 235                 240 


Leu Leu Pro Leu Tyr Ser Ser Asp Glu Thr Ile Ile Ala Thr Leu Val 
                245                 250                 255     


His Ser Asp Leu Tyr Met Glu Ala Asn Leu Asp Tyr Glu Phe Lys Leu 
            260                 265                 270         


Thr Ser Ala Lys Tyr Thr Val Ala Thr Ala Arg Lys Arg His Glu His 
        275                 280                 285             


Ile Thr Gly Arg Asn Glu Ala Val Met Asn Leu Ser Lys Pro Glu Trp 
    290                 295                 300                 


Arg Asn Ile Ile Glu Asn Tyr Leu Leu Asn Ile Ala Val Glu Ala Gln 
305                 310                 315                 320 


Cys Arg Phe Asp Phe Lys Gln Arg Cys Ser Glu Tyr Lys Lys Trp Lys 
                325                 330                 335     


Leu Gln Gln Ser Asn Leu Lys Arg Pro Asp Met Pro Pro Pro Ser Ile 
            340                 345                 350         


Ile Pro Arg Lys Asn Ser Thr Glu Thr Lys Ser Leu Leu Lys Lys Ala 
        355                 360                 365             


Leu Leu Lys Asn Ile Gln Leu Lys Asn Pro Asn Asn Asn Leu Asp Glu 
    370                 375                 380                 


Leu Met Met Arg Ser Ser Ala Ala Thr Asn Gln Gln Gly Lys Asn Lys 
385                 390                 395                 400 


Val Ser Leu Ser Lys Glu Glu Lys Ala Thr Ile Trp Ser Gln Cys Gln 
                405                 410                 415     


Ala Gln Val Tyr Gln Arg Leu Gly Leu Asp Trp Gln Pro Asp Ser Val 
            420                 425                 430         


Ser 
    


<210>  6
<211>  500
<212>  PRT
<213>  Saccharomyces cerevisiae


<220>
<221>  MISC_FEATURE
<223>  S. cerevisiae ALD6 (Accession NO. NP_015264)

<400>  6

Met Thr Lys Leu His Phe Asp Thr Ala Glu Pro Val Lys Ile Thr Leu 
1               5                   10                  15      


Pro Asn Gly Leu Thr Tyr Glu Gln Pro Thr Gly Leu Phe Ile Asn Asn 
            20                  25                  30          


Lys Phe Met Lys Ala Gln Asp Gly Lys Thr Tyr Pro Val Glu Asp Pro 
        35                  40                  45              


Ser Thr Glu Asn Thr Val Cys Glu Val Ser Ser Ala Thr Thr Glu Asp 
    50                  55                  60                  


Val Glu Tyr Ala Ile Glu Cys Ala Asp Arg Ala Phe His Asp Thr Glu 
65                  70                  75                  80  


Trp Ala Thr Gln Asp Pro Arg Glu Arg Gly Arg Leu Leu Ser Lys Leu 
                85                  90                  95      


Ala Asp Glu Leu Glu Ser Gln Ile Asp Leu Val Ser Ser Ile Glu Ala 
            100                 105                 110         


Leu Asp Asn Gly Lys Thr Leu Ala Leu Ala Arg Gly Asp Val Thr Ile 
        115                 120                 125             


Ala Ile Asn Cys Leu Arg Asp Ala Ala Ala Tyr Ala Asp Lys Val Asn 
    130                 135                 140                 


Gly Arg Thr Ile Asn Thr Gly Asp Gly Tyr Met Asn Phe Thr Thr Leu 
145                 150                 155                 160 


Glu Pro Ile Gly Val Cys Gly Gln Ile Ile Pro Trp Asn Phe Pro Ile 
                165                 170                 175     


Met Met Leu Ala Trp Lys Ile Ala Pro Ala Leu Ala Met Gly Asn Val 
            180                 185                 190         


Cys Ile Leu Lys Pro Ala Ala Val Thr Pro Leu Asn Ala Leu Tyr Phe 
        195                 200                 205             


Ala Ser Leu Cys Lys Lys Val Gly Ile Pro Ala Gly Val Val Asn Ile 
    210                 215                 220                 


Val Pro Gly Pro Gly Arg Thr Val Gly Ala Ala Leu Thr Asn Asp Pro 
225                 230                 235                 240 


Arg Ile Arg Lys Leu Ala Phe Thr Gly Ser Thr Glu Val Gly Lys Ser 
                245                 250                 255     


Val Ala Val Asp Ser Ser Glu Ser Asn Leu Lys Lys Ile Thr Leu Glu 
            260                 265                 270         


Leu Gly Gly Lys Ser Ala His Leu Val Phe Asp Asp Ala Asn Ile Lys 
        275                 280                 285             


Lys Thr Leu Pro Asn Leu Val Asn Gly Ile Phe Lys Asn Ala Gly Gln 
    290                 295                 300                 


Ile Cys Ser Ser Gly Ser Arg Ile Tyr Val Gln Glu Gly Ile Tyr Asp 
305                 310                 315                 320 


Glu Leu Leu Ala Ala Phe Lys Ala Tyr Leu Glu Thr Glu Ile Lys Val 
                325                 330                 335     


Gly Asn Pro Phe Asp Lys Ala Asn Phe Gln Gly Ala Ile Thr Asn Arg 
            340                 345                 350         


Gln Gln Phe Asp Thr Ile Met Asn Tyr Ile Asp Ile Gly Lys Lys Glu 
        355                 360                 365             


Gly Ala Lys Ile Leu Thr Gly Gly Glu Lys Val Gly Asp Lys Gly Tyr 
    370                 375                 380                 


Phe Ile Arg Pro Thr Val Phe Tyr Asp Val Asn Glu Asp Met Arg Ile 
385                 390                 395                 400 


Val Lys Glu Glu Ile Phe Gly Pro Val Val Thr Val Ala Lys Phe Lys 
                405                 410                 415     


Thr Leu Glu Glu Gly Val Glu Met Ala Asn Ser Ser Glu Phe Gly Leu 
            420                 425                 430         


Gly Ser Gly Ile Glu Thr Glu Ser Leu Ser Thr Gly Leu Lys Val Ala 
        435                 440                 445             


Lys Met Leu Lys Ala Gly Thr Val Trp Ile Asn Thr Tyr Asn Asp Phe 
    450                 455                 460                 


Asp Ser Arg Val Pro Phe Gly Gly Val Lys Gln Ser Gly Tyr Gly Arg 
465                 470                 475                 480 


Glu Met Gly Glu Glu Val Tyr His Ala Tyr Thr Glu Val Lys Ala Val 
                485                 490                 495     


Arg Ile Lys Leu 
            500 


<210>  7
<211>  348
<212>  PRT
<213>  Saccharomyces cerevisiae


<220>
<221>  MISC_FEATURE
<223>  S. cerevisiae ADH1 (Accession No. NP_014555)

<400>  7

Met Ser Ile Pro Glu Thr Gln Lys Gly Val Ile Phe Tyr Glu Ser His 
1               5                   10                  15      


Gly Lys Leu Glu Tyr Lys Asp Ile Pro Val Pro Lys Pro Lys Ala Asn 
            20                  25                  30          


Glu Leu Leu Ile Asn Val Lys Tyr Ser Gly Val Cys His Thr Asp Leu 
        35                  40                  45              


His Ala Trp His Gly Asp Trp Pro Leu Pro Val Lys Leu Pro Leu Val 
    50                  55                  60                  


Gly Gly His Glu Gly Ala Gly Val Val Val Gly Met Gly Glu Asn Val 
65                  70                  75                  80  


Lys Gly Trp Lys Ile Gly Asp Tyr Ala Gly Ile Lys Trp Leu Asn Gly 
                85                  90                  95      


Ser Cys Met Ala Cys Glu Tyr Cys Glu Leu Gly Asn Glu Ser Asn Cys 
            100                 105                 110         


Pro His Ala Asp Leu Ser Gly Tyr Thr His Asp Gly Ser Phe Gln Gln 
        115                 120                 125             


Tyr Ala Thr Ala Asp Ala Val Gln Ala Ala His Ile Pro Gln Gly Thr 
    130                 135                 140                 


Asp Leu Ala Gln Val Ala Pro Ile Leu Cys Ala Gly Ile Thr Val Tyr 
145                 150                 155                 160 


Lys Ala Leu Lys Ser Ala Asn Leu Met Ala Gly His Trp Val Ala Ile 
                165                 170                 175     


Ser Gly Ala Ala Gly Gly Leu Gly Ser Leu Ala Val Gln Tyr Ala Lys 
            180                 185                 190         


Ala Met Gly Tyr Arg Val Leu Gly Ile Asp Gly Gly Glu Gly Lys Glu 
        195                 200                 205             


Glu Leu Phe Arg Ser Ile Gly Gly Glu Val Phe Ile Asp Phe Thr Lys 
    210                 215                 220                 


Glu Lys Asp Ile Val Gly Ala Val Leu Lys Ala Thr Asp Gly Gly Ala 
225                 230                 235                 240 


His Gly Val Ile Asn Val Ser Val Ser Glu Ala Ala Ile Glu Ala Ser 
                245                 250                 255     


Thr Arg Tyr Val Arg Ala Asn Gly Thr Thr Val Leu Val Gly Met Pro 
            260                 265                 270         


Ala Gly Ala Lys Cys Cys Ser Asp Val Phe Asn Gln Val Val Lys Ser 
        275                 280                 285             


Ile Ser Ile Val Gly Ser Tyr Val Gly Asn Arg Ala Asp Thr Arg Glu 
    290                 295                 300                 


Ala Leu Asp Phe Phe Ala Arg Gly Leu Val Lys Ser Pro Ile Lys Val 
305                 310                 315                 320 


Val Gly Leu Ser Thr Leu Pro Glu Ile Tyr Glu Lys Met Glu Lys Gly 
                325                 330                 335     


Gln Ile Val Gly Arg Tyr Val Val Asp Thr Ser Lys 
            340                 345             


<210>  8
<211>  713
<212>  PRT
<213>  Saccharomyces cerevisiae


<220>
<221>  MISC_FEATURE
<223>  S. cerevisiae ACS1 (Accession No. NP_009347)

<400>  8

Met Ser Pro Ser Ala Val Gln Ser Ser Lys Leu Glu Glu Gln Ser Ser 
1               5                   10                  15      


Glu Ile Asp Lys Leu Lys Ala Lys Met Ser Gln Ser Ala Ala Thr Ala 
            20                  25                  30          


Gln Gln Lys Lys Glu His Glu Tyr Glu His Leu Thr Ser Val Lys Ile 
        35                  40                  45              


Val Pro Gln Arg Pro Ile Ser Asp Arg Leu Gln Pro Ala Ile Ala Thr 
    50                  55                  60                  


His Tyr Ser Pro His Leu Asp Gly Leu Gln Asp Tyr Gln Arg Leu His 
65                  70                  75                  80  


Lys Glu Ser Ile Glu Asp Pro Ala Lys Phe Phe Gly Ser Lys Ala Thr 
                85                  90                  95      


Gln Phe Leu Asn Trp Ser Lys Pro Phe Asp Lys Val Phe Ile Pro Asp 
            100                 105                 110         


Pro Lys Thr Gly Arg Pro Ser Phe Gln Asn Asn Ala Trp Phe Leu Asn 
        115                 120                 125             


Gly Gln Leu Asn Ala Cys Tyr Asn Cys Val Asp Arg His Ala Leu Lys 
    130                 135                 140                 


Thr Pro Asn Lys Lys Ala Ile Ile Phe Glu Gly Asp Glu Pro Gly Gln 
145                 150                 155                 160 


Gly Tyr Ser Ile Thr Tyr Lys Glu Leu Leu Glu Glu Val Cys Gln Val 
                165                 170                 175     


Ala Gln Val Leu Thr Tyr Ser Met Gly Val Arg Lys Gly Asp Thr Val 
            180                 185                 190         


Ala Val Tyr Met Pro Met Val Pro Glu Ala Ile Ile Thr Leu Leu Ala 
        195                 200                 205             


Ile Ser Arg Ile Gly Ala Ile His Ser Val Val Phe Ala Gly Phe Ser 
    210                 215                 220                 


Ser Asn Ser Leu Arg Asp Arg Ile Asn Asp Gly Asp Ser Lys Val Val 
225                 230                 235                 240 


Ile Thr Thr Asp Glu Ser Asn Arg Gly Gly Lys Val Ile Glu Thr Lys 
                245                 250                 255     


Arg Ile Val Asp Asp Ala Leu Arg Glu Thr Pro Gly Val Arg His Val 
            260                 265                 270         


Leu Val Tyr Arg Lys Thr Asn Asn Pro Ser Val Ala Phe His Ala Pro 
        275                 280                 285             


Arg Asp Leu Asp Trp Ala Thr Glu Lys Lys Lys Tyr Lys Thr Tyr Tyr 
    290                 295                 300                 


Pro Cys Thr Pro Val Asp Ser Glu Asp Pro Leu Phe Leu Leu Tyr Thr 
305                 310                 315                 320 


Ser Gly Ser Thr Gly Ala Pro Lys Gly Val Gln His Ser Thr Ala Gly 
                325                 330                 335     


Tyr Leu Leu Gly Ala Leu Leu Thr Met Arg Tyr Thr Phe Asp Thr His 
            340                 345                 350         


Gln Glu Asp Val Phe Phe Thr Ala Gly Asp Ile Gly Trp Ile Thr Gly 
        355                 360                 365             


His Thr Tyr Val Val Tyr Gly Pro Leu Leu Tyr Gly Cys Ala Thr Leu 
    370                 375                 380                 


Val Phe Glu Gly Thr Pro Ala Tyr Pro Asn Tyr Ser Arg Tyr Trp Asp 
385                 390                 395                 400 


Ile Ile Asp Glu His Lys Val Thr Gln Phe Tyr Val Ala Pro Thr Ala 
                405                 410                 415     


Leu Arg Leu Leu Lys Arg Ala Gly Asp Ser Tyr Ile Glu Asn His Ser 
            420                 425                 430         


Leu Lys Ser Leu Arg Cys Leu Gly Ser Val Gly Glu Pro Ile Ala Ala 
        435                 440                 445             


Glu Val Trp Glu Trp Tyr Ser Glu Lys Ile Gly Lys Asn Glu Ile Pro 
    450                 455                 460                 


Ile Val Asp Thr Tyr Trp Gln Thr Glu Ser Gly Ser His Leu Val Thr 
465                 470                 475                 480 


Pro Leu Ala Gly Gly Val Thr Pro Met Lys Pro Gly Ser Ala Ser Phe 
                485                 490                 495     


Pro Phe Phe Gly Ile Asp Ala Val Val Leu Asp Pro Asn Thr Gly Glu 
            500                 505                 510         


Glu Leu Asn Thr Ser His Ala Glu Gly Val Leu Ala Val Lys Ala Ala 
        515                 520                 525             


Trp Pro Ser Phe Ala Arg Thr Ile Trp Lys Asn His Asp Arg Tyr Leu 
    530                 535                 540                 


Asp Thr Tyr Leu Asn Pro Tyr Pro Gly Tyr Tyr Phe Thr Gly Asp Gly 
545                 550                 555                 560 


Ala Ala Lys Asp Lys Asp Gly Tyr Ile Trp Ile Leu Gly Arg Val Asp 
                565                 570                 575     


Asp Val Val Asn Val Ser Gly His Arg Leu Ser Thr Ala Glu Ile Glu 
            580                 585                 590         


Ala Ala Ile Ile Glu Asp Pro Ile Val Ala Glu Cys Ala Val Val Gly 
        595                 600                 605             


Phe Asn Asp Asp Leu Thr Gly Gln Ala Val Ala Ala Phe Val Val Leu 
    610                 615                 620                 


Lys Asn Lys Ser Ser Trp Ser Thr Ala Thr Asp Asp Glu Leu Gln Asp 
625                 630                 635                 640 


Ile Lys Lys His Leu Val Phe Thr Val Arg Lys Asp Ile Gly Pro Phe 
                645                 650                 655     


Ala Ala Pro Lys Leu Ile Ile Leu Val Asp Asp Leu Pro Lys Thr Arg 
            660                 665                 670         


Ser Gly Lys Ile Met Arg Arg Ile Leu Arg Lys Ile Leu Ala Gly Glu 
        675                 680                 685             


Ser Asp Gln Leu Gly Asp Val Ser Thr Leu Ser Asn Pro Gly Ile Val 
    690                 695                 700                 


Arg His Leu Ile Asp Ser Val Lys Leu 
705                 710             


<210>  9
<211>  683
<212>  PRT
<213>  Saccharomyces cerevisiae


<220>
<221>  MISC_FEATURE
<223>  S. cerevisiae ACS2 (Accession No. NP_013254)

<400>  9

Met Thr Ile Lys Glu His Lys Val Val Tyr Glu Ala His Asn Val Lys 
1               5                   10                  15      


Ala Leu Lys Ala Pro Gln His Phe Tyr Asn Ser Gln Pro Gly Lys Gly 
            20                  25                  30          


Tyr Val Thr Asp Met Gln His Tyr Gln Glu Met Tyr Gln Gln Ser Ile 
        35                  40                  45              


Asn Glu Pro Glu Lys Phe Phe Asp Lys Met Ala Lys Glu Tyr Leu His 
    50                  55                  60                  


Trp Asp Ala Pro Tyr Thr Lys Val Gln Ser Gly Ser Leu Asn Asn Gly 
65                  70                  75                  80  


Asp Val Ala Trp Phe Leu Asn Gly Lys Leu Asn Ala Ser Tyr Asn Cys 
                85                  90                  95      


Val Asp Arg His Ala Phe Ala Asn Pro Asp Lys Pro Ala Leu Ile Tyr 
            100                 105                 110         


Glu Ala Asp Asp Glu Ser Asp Asn Lys Ile Ile Thr Phe Gly Glu Leu 
        115                 120                 125             


Leu Arg Lys Val Ser Gln Ile Ala Gly Val Leu Lys Ser Trp Gly Val 
    130                 135                 140                 


Lys Lys Gly Asp Thr Val Ala Ile Tyr Leu Pro Met Ile Pro Glu Ala 
145                 150                 155                 160 


Val Ile Ala Met Leu Ala Val Ala Arg Ile Gly Ala Ile His Ser Val 
                165                 170                 175     


Val Phe Ala Gly Phe Ser Ala Gly Ser Leu Lys Asp Arg Val Val Asp 
            180                 185                 190         


Ala Asn Ser Lys Val Val Ile Thr Cys Asp Glu Gly Lys Arg Gly Gly 
        195                 200                 205             


Lys Thr Ile Asn Thr Lys Lys Ile Val Asp Glu Gly Leu Asn Gly Val 
    210                 215                 220                 


Asp Leu Val Ser Arg Ile Leu Val Phe Gln Arg Thr Gly Thr Glu Gly 
225                 230                 235                 240 


Ile Pro Met Lys Ala Gly Arg Asp Tyr Trp Trp His Glu Glu Ala Ala 
                245                 250                 255     


Lys Gln Arg Thr Tyr Leu Pro Pro Val Ser Cys Asp Ala Glu Asp Pro 
            260                 265                 270         


Leu Phe Leu Leu Tyr Thr Ser Gly Ser Thr Gly Ser Pro Lys Gly Val 
        275                 280                 285             


Val His Thr Thr Gly Gly Tyr Leu Leu Gly Ala Ala Leu Thr Thr Arg 
    290                 295                 300                 


Tyr Val Phe Asp Ile His Pro Glu Asp Val Leu Phe Thr Ala Gly Asp 
305                 310                 315                 320 


Val Gly Trp Ile Thr Gly His Thr Tyr Ala Leu Tyr Gly Pro Leu Thr 
                325                 330                 335     


Leu Gly Thr Ala Ser Ile Ile Phe Glu Ser Thr Pro Ala Tyr Pro Asp 
            340                 345                 350         


Tyr Gly Arg Tyr Trp Arg Ile Ile Gln Arg His Lys Ala Thr His Phe 
        355                 360                 365             


Tyr Val Ala Pro Thr Ala Leu Arg Leu Ile Lys Arg Val Gly Glu Ala 
    370                 375                 380                 


Glu Ile Ala Lys Tyr Asp Thr Ser Ser Leu Arg Val Leu Gly Ser Val 
385                 390                 395                 400 


Gly Glu Pro Ile Ser Pro Asp Leu Trp Glu Trp Tyr His Glu Lys Val 
                405                 410                 415     


Gly Asn Lys Asn Cys Val Ile Cys Asp Thr Met Trp Gln Thr Glu Ser 
            420                 425                 430         


Gly Ser His Leu Ile Ala Pro Leu Ala Gly Ala Val Pro Thr Lys Pro 
        435                 440                 445             


Gly Ser Ala Thr Val Pro Phe Phe Gly Ile Asn Ala Cys Ile Ile Asp 
    450                 455                 460                 


Pro Val Thr Gly Val Glu Leu Glu Gly Asn Asp Val Glu Gly Val Leu 
465                 470                 475                 480 


Ala Val Lys Ser Pro Trp Pro Ser Met Ala Arg Ser Val Trp Asn His 
                485                 490                 495     


His Asp Arg Tyr Met Asp Thr Tyr Leu Lys Pro Tyr Pro Gly His Tyr 
            500                 505                 510         


Phe Thr Gly Asp Gly Ala Gly Arg Asp His Asp Gly Tyr Tyr Trp Ile 
        515                 520                 525             


Arg Gly Arg Val Asp Asp Val Val Asn Val Ser Gly His Arg Leu Ser 
    530                 535                 540                 


Thr Ser Glu Ile Glu Ala Ser Ile Ser Asn His Glu Asn Val Ser Glu 
545                 550                 555                 560 


Ala Ala Val Val Gly Ile Pro Asp Glu Leu Thr Gly Gln Thr Val Val 
                565                 570                 575     


Ala Tyr Val Ser Leu Lys Asp Gly Tyr Leu Gln Asn Asn Ala Thr Glu 
            580                 585                 590         


Gly Asp Ala Glu His Ile Thr Pro Asp Asn Leu Arg Arg Glu Leu Ile 
        595                 600                 605             


Leu Gln Val Arg Gly Glu Ile Gly Pro Phe Ala Ser Pro Lys Thr Ile 
    610                 615                 620                 


Ile Leu Val Arg Asp Leu Pro Arg Thr Arg Ser Gly Lys Ile Met Arg 
625                 630                 635                 640 


Arg Val Leu Arg Lys Val Ala Ser Asn Glu Ala Glu Gln Leu Gly Asp 
                645                 650                 655     


Leu Thr Thr Leu Ala Asn Pro Glu Val Val Pro Ala Ile Ile Ser Ala 
            660                 665                 670         


Val Glu Asn Gln Phe Phe Ser Gln Lys Lys Lys 
        675                 680             


<210>  10
<211>  2233
<212>  PRT
<213>  Saccharomyces cerevisiae


<220>
<221>  MISC_FEATURE
<223>  S. cerevisiae ACC1 (Accession No. NP_014413)

<400>  10

Met Ser Glu Glu Ser Leu Phe Glu Ser Ser Pro Gln Lys Met Glu Tyr 
1               5                   10                  15      


Glu Ile Thr Asn Tyr Ser Glu Arg His Thr Glu Leu Pro Gly His Phe 
            20                  25                  30          


Ile Gly Leu Asn Thr Val Asp Lys Leu Glu Glu Ser Pro Leu Arg Asp 
        35                  40                  45              


Phe Val Lys Ser His Gly Gly His Thr Val Ile Ser Lys Ile Leu Ile 
    50                  55                  60                  


Ala Asn Asn Gly Ile Ala Ala Val Lys Glu Ile Arg Ser Val Arg Lys 
65                  70                  75                  80  


Trp Ala Tyr Glu Thr Phe Gly Asp Asp Arg Thr Val Gln Phe Val Ala 
                85                  90                  95      


Met Ala Thr Pro Glu Asp Leu Glu Ala Asn Ala Glu Tyr Ile Arg Met 
            100                 105                 110         


Ala Asp Gln Tyr Ile Glu Val Pro Gly Gly Thr Asn Asn Asn Asn Tyr 
        115                 120                 125             


Ala Asn Val Asp Leu Ile Val Asp Ile Ala Glu Arg Ala Asp Val Asp 
    130                 135                 140                 


Ala Val Trp Ala Gly Trp Gly His Ala Ser Glu Asn Pro Leu Leu Pro 
145                 150                 155                 160 


Glu Lys Leu Ser Gln Ser Lys Arg Lys Val Ile Phe Ile Gly Pro Pro 
                165                 170                 175     


Gly Asn Ala Met Arg Ser Leu Gly Asp Lys Ile Ser Ser Thr Ile Val 
            180                 185                 190         


Ala Gln Ser Ala Lys Val Pro Cys Ile Pro Trp Ser Gly Thr Gly Val 
        195                 200                 205             


Asp Thr Val His Val Asp Glu Lys Thr Gly Leu Val Ser Val Asp Asp 
    210                 215                 220                 


Asp Ile Tyr Gln Lys Gly Cys Cys Thr Ser Pro Glu Asp Gly Leu Gln 
225                 230                 235                 240 


Lys Ala Lys Arg Ile Gly Phe Pro Val Met Ile Lys Ala Ser Glu Gly 
                245                 250                 255     


Gly Gly Gly Lys Gly Ile Arg Gln Val Glu Arg Glu Glu Asp Phe Ile 
            260                 265                 270         


Ala Leu Tyr His Gln Ala Ala Asn Glu Ile Pro Gly Ser Pro Ile Phe 
        275                 280                 285             


Ile Met Lys Leu Ala Gly Arg Ala Arg His Leu Glu Val Gln Leu Leu 
    290                 295                 300                 


Ala Asp Gln Tyr Gly Thr Asn Ile Ser Leu Phe Gly Arg Asp Cys Ser 
305                 310                 315                 320 


Val Gln Arg Arg His Gln Lys Ile Ile Glu Glu Ala Pro Val Thr Ile 
                325                 330                 335     


Ala Lys Ala Glu Thr Phe His Glu Met Glu Lys Ala Ala Val Arg Leu 
            340                 345                 350         


Gly Lys Leu Val Gly Tyr Val Ser Ala Gly Thr Val Glu Tyr Leu Tyr 
        355                 360                 365             


Ser His Asp Asp Gly Lys Phe Tyr Phe Leu Glu Leu Asn Pro Arg Leu 
    370                 375                 380                 


Gln Val Glu His Pro Thr Thr Glu Met Val Ser Gly Val Asn Leu Pro 
385                 390                 395                 400 


Ala Ala Gln Leu Gln Ile Ala Met Gly Ile Pro Met His Arg Ile Ser 
                405                 410                 415     


Asp Ile Arg Thr Leu Tyr Gly Met Asn Pro His Ser Ala Ser Glu Ile 
            420                 425                 430         


Asp Phe Glu Phe Lys Thr Gln Asp Ala Thr Lys Lys Gln Arg Arg Pro 
        435                 440                 445             


Ile Pro Lys Gly His Cys Thr Ala Cys Arg Ile Thr Ser Glu Asp Pro 
    450                 455                 460                 


Asn Asp Gly Phe Lys Pro Ser Gly Gly Thr Leu His Glu Leu Asn Phe 
465                 470                 475                 480 


Arg Ser Ser Ser Asn Val Trp Gly Tyr Phe Ser Val Gly Asn Asn Gly 
                485                 490                 495     


Asn Ile His Ser Phe Ser Asp Ser Gln Phe Gly His Ile Phe Ala Phe 
            500                 505                 510         


Gly Glu Asn Arg Gln Ala Ser Arg Lys His Met Val Val Ala Leu Lys 
        515                 520                 525             


Glu Leu Ser Ile Arg Gly Asp Phe Arg Thr Thr Val Glu Tyr Leu Ile 
    530                 535                 540                 


Lys Leu Leu Glu Thr Glu Asp Phe Glu Asp Asn Thr Ile Thr Thr Gly 
545                 550                 555                 560 


Trp Leu Asp Asp Leu Ile Thr His Lys Met Thr Ala Glu Lys Pro Asp 
                565                 570                 575     


Pro Thr Leu Ala Val Ile Cys Gly Ala Ala Thr Lys Ala Phe Leu Ala 
            580                 585                 590         


Ser Glu Glu Ala Arg His Lys Tyr Ile Glu Ser Leu Gln Lys Gly Gln 
        595                 600                 605             


Val Leu Ser Lys Asp Leu Leu Gln Thr Met Phe Pro Val Asp Phe Ile 
    610                 615                 620                 


His Glu Gly Lys Arg Tyr Lys Phe Thr Val Ala Lys Ser Gly Asn Asp 
625                 630                 635                 640 


Arg Tyr Thr Leu Phe Ile Asn Gly Ser Lys Cys Asp Ile Ile Leu Arg 
                645                 650                 655     


Gln Leu Ser Asp Gly Gly Leu Leu Ile Ala Ile Gly Gly Lys Ser His 
            660                 665                 670         


Thr Ile Tyr Trp Lys Glu Glu Val Ala Ala Thr Arg Leu Ser Val Asp 
        675                 680                 685             


Ser Met Thr Thr Leu Leu Glu Val Glu Asn Asp Pro Thr Gln Leu Arg 
    690                 695                 700                 


Thr Pro Ser Pro Gly Lys Leu Val Lys Phe Leu Val Glu Asn Gly Glu 
705                 710                 715                 720 


His Ile Ile Lys Gly Gln Pro Tyr Ala Glu Ile Glu Val Met Lys Met 
                725                 730                 735     


Gln Met Pro Leu Val Ser Gln Glu Asn Gly Ile Val Gln Leu Leu Lys 
            740                 745                 750         


Gln Pro Gly Ser Thr Ile Val Ala Gly Asp Ile Met Ala Ile Met Thr 
        755                 760                 765             


Leu Asp Asp Pro Ser Lys Val Lys His Ala Leu Pro Phe Glu Gly Met 
    770                 775                 780                 


Leu Pro Asp Phe Gly Ser Pro Val Ile Glu Gly Thr Lys Pro Ala Tyr 
785                 790                 795                 800 


Lys Phe Lys Ser Leu Val Ser Thr Leu Glu Asn Ile Leu Lys Gly Tyr 
                805                 810                 815     


Asp Asn Gln Val Ile Met Asn Ala Ser Leu Gln Gln Leu Ile Glu Val 
            820                 825                 830         


Leu Arg Asn Pro Lys Leu Pro Tyr Ser Glu Trp Lys Leu His Ile Ser 
        835                 840                 845             


Ala Leu His Ser Arg Leu Pro Ala Lys Leu Asp Glu Gln Met Glu Glu 
    850                 855                 860                 


Leu Val Ala Arg Ser Leu Arg Arg Gly Ala Val Phe Pro Ala Arg Gln 
865                 870                 875                 880 


Leu Ser Lys Leu Ile Asp Met Ala Val Lys Asn Pro Glu Tyr Asn Pro 
                885                 890                 895     


Asp Lys Leu Leu Gly Ala Val Val Glu Pro Leu Ala Asp Ile Ala His 
            900                 905                 910         


Lys Tyr Ser Asn Gly Leu Glu Ala His Glu His Ser Ile Phe Val His 
        915                 920                 925             


Phe Leu Glu Glu Tyr Tyr Glu Val Glu Lys Leu Phe Asn Gly Pro Asn 
    930                 935                 940                 


Val Arg Glu Glu Asn Ile Ile Leu Lys Leu Arg Asp Glu Asn Pro Lys 
945                 950                 955                 960 


Asp Leu Asp Lys Val Ala Leu Thr Val Leu Ser His Ser Lys Val Ser 
                965                 970                 975     


Ala Lys Asn Asn Leu Ile Leu Ala Ile Leu Lys His Tyr Gln Pro Leu 
            980                 985                 990         


Cys Lys Leu Ser Ser Lys Val Ser  Ala Ile Phe Ser Thr  Pro Leu Gln 
        995                 1000                 1005             


His Ile  Val Glu Leu Glu Ser  Lys Ala Thr Ala Lys  Val Ala Leu 
    1010                 1015                 1020             


Gln Ala  Arg Glu Ile Leu Ile  Gln Gly Ala Leu Pro  Ser Val Lys 
    1025                 1030                 1035             


Glu Arg  Thr Glu Gln Ile Glu  His Ile Leu Lys Ser  Ser Val Val 
    1040                 1045                 1050             


Lys Val  Ala Tyr Gly Ser Ser  Asn Pro Lys Arg Ser  Glu Pro Asp 
    1055                 1060                 1065             


Leu Asn  Ile Leu Lys Asp Leu  Ile Asp Ser Asn Tyr  Val Val Phe 
    1070                 1075                 1080             


Asp Val  Leu Leu Gln Phe Leu  Thr His Gln Asp Pro  Val Val Thr 
    1085                 1090                 1095             


Ala Ala  Ala Ala Gln Val Tyr  Ile Arg Arg Ala Tyr  Arg Ala Tyr 
    1100                 1105                 1110             


Thr Ile  Gly Asp Ile Arg Val  His Glu Gly Val Thr  Val Pro Ile 
    1115                 1120                 1125             


Val Glu  Trp Lys Phe Gln Leu  Pro Ser Ala Ala Phe  Ser Thr Phe 
    1130                 1135                 1140             


Pro Thr  Val Lys Ser Lys Met  Gly Met Asn Arg Ala  Val Ser Val 
    1145                 1150                 1155             


Ser Asp  Leu Ser Tyr Val Ala  Asn Ser Gln Ser Ser  Pro Leu Arg 
    1160                 1165                 1170             


Glu Gly  Ile Leu Met Ala Val  Asp His Leu Asp Asp  Val Asp Glu 
    1175                 1180                 1185             


Ile Leu  Ser Gln Ser Leu Glu  Val Ile Pro Arg His  Gln Ser Ser 
    1190                 1195                 1200             


Ser Asn  Gly Pro Ala Pro Asp  Arg Ser Gly Ser Ser  Ala Ser Leu 
    1205                 1210                 1215             


Ser Asn  Val Ala Asn Val Cys  Val Ala Ser Thr Glu  Gly Phe Glu 
    1220                 1225                 1230             


Ser Glu  Glu Glu Ile Leu Val  Arg Leu Arg Glu Ile  Leu Asp Leu 
    1235                 1240                 1245             


Asn Lys  Gln Glu Leu Ile Asn  Ala Ser Ile Arg Arg  Ile Thr Phe 
    1250                 1255                 1260             


Met Phe  Gly Phe Lys Asp Gly  Ser Tyr Pro Lys Tyr  Tyr Thr Phe 
    1265                 1270                 1275             


Asn Gly  Pro Asn Tyr Asn Glu  Asn Glu Thr Ile Arg  His Ile Glu 
    1280                 1285                 1290             


Pro Ala  Leu Ala Phe Gln Leu  Glu Leu Gly Arg Leu  Ser Asn Phe 
    1295                 1300                 1305             


Asn Ile  Lys Pro Ile Phe Thr  Asp Asn Arg Asn Ile  His Val Tyr 
    1310                 1315                 1320             


Glu Ala  Val Ser Lys Thr Ser  Pro Leu Asp Lys Arg  Phe Phe Thr 
    1325                 1330                 1335             


Arg Gly  Ile Ile Arg Thr Gly  His Ile Arg Asp Asp  Ile Ser Ile 
    1340                 1345                 1350             


Gln Glu  Tyr Leu Thr Ser Glu  Ala Asn Arg Leu Met  Ser Asp Ile 
    1355                 1360                 1365             


Leu Asp  Asn Leu Glu Val Thr  Asp Thr Ser Asn Ser  Asp Leu Asn 
    1370                 1375                 1380             


His Ile  Phe Ile Asn Phe Ile  Ala Val Phe Asp Ile  Ser Pro Glu 
    1385                 1390                 1395             


Asp Val  Glu Ala Ala Phe Gly  Gly Phe Leu Glu Arg  Phe Gly Lys 
    1400                 1405                 1410             


Arg Leu  Leu Arg Leu Arg Val  Ser Ser Ala Glu Ile  Arg Ile Ile 
    1415                 1420                 1425             


Ile Lys  Asp Pro Gln Thr Gly  Ala Pro Val Pro Leu  Arg Ala Leu 
    1430                 1435                 1440             


Ile Asn  Asn Val Ser Gly Tyr  Val Ile Lys Thr Glu  Met Tyr Thr 
    1445                 1450                 1455             


Glu Val  Lys Asn Ala Lys Gly  Glu Trp Val Phe Lys  Ser Leu Gly 
    1460                 1465                 1470             


Lys Pro  Gly Ser Met His Leu  Arg Pro Ile Ala Thr  Pro Tyr Pro 
    1475                 1480                 1485             


Val Lys  Glu Trp Leu Gln Pro  Lys Arg Tyr Lys Ala  His Leu Met 
    1490                 1495                 1500             


Gly Thr  Thr Tyr Val Tyr Asp  Phe Pro Glu Leu Phe  Arg Gln Ala 
    1505                 1510                 1515             


Ser Ser  Ser Gln Trp Lys Asn  Phe Ser Ala Asp Val  Lys Leu Thr 
    1520                 1525                 1530             


Asp Asp  Phe Phe Ile Ser Asn  Glu Leu Ile Glu Asp  Glu Asn Gly 
    1535                 1540                 1545             


Glu Leu  Thr Glu Val Glu Arg  Glu Pro Gly Ala Asn  Ala Ile Gly 
    1550                 1555                 1560             


Met Val  Ala Phe Lys Ile Thr  Val Lys Thr Pro Glu  Tyr Pro Arg 
    1565                 1570                 1575             


Gly Arg  Gln Phe Val Val Val  Ala Asn Asp Ile Thr  Phe Lys Ile 
    1580                 1585                 1590             


Gly Ser  Phe Gly Pro Gln Glu  Asp Glu Phe Phe Asn  Lys Val Thr 
    1595                 1600                 1605             


Glu Tyr  Ala Arg Lys Arg Gly  Ile Pro Arg Ile Tyr  Leu Ala Ala 
    1610                 1615                 1620             


Asn Ser  Gly Ala Arg Ile Gly  Met Ala Glu Glu Ile  Val Pro Leu 
    1625                 1630                 1635             


Phe Gln  Val Ala Trp Asn Asp  Ala Ala Asn Pro Asp  Lys Gly Phe 
    1640                 1645                 1650             


Gln Tyr  Leu Tyr Leu Thr Ser  Glu Gly Met Glu Thr  Leu Lys Lys 
    1655                 1660                 1665             


Phe Asp  Lys Glu Asn Ser Val  Leu Thr Glu Arg Thr  Val Ile Asn 
    1670                 1675                 1680             


Gly Glu  Glu Arg Phe Val Ile  Lys Thr Ile Ile Gly  Ser Glu Asp 
    1685                 1690                 1695             


Gly Leu  Gly Val Glu Cys Leu  Arg Gly Ser Gly Leu  Ile Ala Gly 
    1700                 1705                 1710             


Ala Thr  Ser Arg Ala Tyr His  Asp Ile Phe Thr Ile  Thr Leu Val 
    1715                 1720                 1725             


Thr Cys  Arg Ser Val Gly Ile  Gly Ala Tyr Leu Val  Arg Leu Gly 
    1730                 1735                 1740             


Gln Arg  Ala Ile Gln Val Glu  Gly Gln Pro Ile Ile  Leu Thr Gly 
    1745                 1750                 1755             


Ala Pro  Ala Ile Asn Lys Met  Leu Gly Arg Glu Val  Tyr Thr Ser 
    1760                 1765                 1770             


Asn Leu  Gln Leu Gly Gly Thr  Gln Ile Met Tyr Asn  Asn Gly Val 
    1775                 1780                 1785             


Ser His  Leu Thr Ala Val Asp  Asp Leu Ala Gly Val  Glu Lys Ile 
    1790                 1795                 1800             


Val Glu  Trp Met Ser Tyr Val  Pro Ala Lys Arg Asn  Met Pro Val 
    1805                 1810                 1815             


Pro Ile  Leu Glu Thr Lys Asp  Thr Trp Asp Arg Pro  Val Asp Phe 
    1820                 1825                 1830             


Thr Pro  Thr Asn Asp Glu Thr  Tyr Asp Val Arg Trp  Met Ile Glu 
    1835                 1840                 1845             


Gly Arg  Glu Thr Glu Ser Gly  Phe Glu Tyr Gly Leu  Phe Asp Lys 
    1850                 1855                 1860             


Gly Ser  Phe Phe Glu Thr Leu  Ser Gly Trp Ala Lys  Gly Val Val 
    1865                 1870                 1875             


Val Gly  Arg Ala Arg Leu Gly  Gly Ile Pro Leu Gly  Val Ile Gly 
    1880                 1885                 1890             


Val Glu  Thr Arg Thr Val Glu  Asn Leu Ile Pro Ala  Asp Pro Ala 
    1895                 1900                 1905             


Asn Pro  Asn Ser Ala Glu Thr  Leu Ile Gln Glu Pro  Gly Gln Val 
    1910                 1915                 1920             


Trp His  Pro Asn Ser Ala Phe  Lys Thr Ala Gln Ala  Ile Asn Asp 
    1925                 1930                 1935             


Phe Asn  Asn Gly Glu Gln Leu  Pro Met Met Ile Leu  Ala Asn Trp 
    1940                 1945                 1950             


Arg Gly  Phe Ser Gly Gly Gln  Arg Asp Met Phe Asn  Glu Val Leu 
    1955                 1960                 1965             


Lys Tyr  Gly Ser Phe Ile Val  Asp Ala Leu Val Asp  Tyr Lys Gln 
    1970                 1975                 1980             


Pro Ile  Ile Ile Tyr Ile Pro  Pro Thr Gly Glu Leu  Arg Gly Gly 
    1985                 1990                 1995             


Ser Trp  Val Val Val Asp Pro  Thr Ile Asn Ala Asp  Gln Met Glu 
    2000                 2005                 2010             


Met Tyr  Ala Asp Val Asn Ala  Arg Ala Gly Val Leu  Glu Pro Gln 
    2015                 2020                 2025             


Gly Met  Val Gly Ile Lys Phe  Arg Arg Glu Lys Leu  Leu Asp Thr 
    2030                 2035                 2040             


Met Asn  Arg Leu Asp Asp Lys  Tyr Arg Glu Leu Arg  Ser Gln Leu 
    2045                 2050                 2055             


Ser Asn  Lys Ser Leu Ala Pro  Glu Val His Gln Gln  Ile Ser Lys 
    2060                 2065                 2070             


Gln Leu  Ala Asp Arg Glu Arg  Glu Leu Leu Pro Ile  Tyr Gly Gln 
    2075                 2080                 2085             


Ile Ser  Leu Gln Phe Ala Asp  Leu His Asp Arg Ser  Ser Arg Met 
    2090                 2095                 2100             


Val Ala  Lys Gly Val Ile Ser  Lys Glu Leu Glu Trp  Thr Glu Ala 
    2105                 2110                 2115             


Arg Arg  Phe Phe Phe Trp Arg  Leu Arg Arg Arg Leu  Asn Glu Glu 
    2120                 2125                 2130             


Tyr Leu  Ile Lys Arg Leu Ser  His Gln Val Gly Glu  Ala Ser Arg 
    2135                 2140                 2145             


Leu Glu  Lys Ile Ala Arg Ile  Arg Ser Trp Tyr Pro  Ala Ser Val 
    2150                 2155                 2160             


Asp His  Glu Asp Asp Arg Gln  Val Ala Thr Trp Ile  Glu Glu Asn 
    2165                 2170                 2175             


Tyr Lys  Thr Leu Asp Asp Lys  Leu Lys Gly Leu Lys  Leu Glu Ser 
    2180                 2185                 2190             


Phe Ala  Gln Asp Leu Ala Lys  Lys Ile Arg Ser Asp  His Asp Asn 
    2195                 2200                 2205             


Ala Ile  Asp Gly Leu Ser Glu  Val Ile Lys Met Leu  Ser Thr Asp 
    2210                 2215                 2220             


Asp Lys  Glu Lys Leu Leu Lys  Thr Leu Lys 
    2225                 2230             


<210>  11
<211>  2051
<212>  PRT
<213>  Saccharomyces cerevisiae


<220>
<221>  MISC_FEATURE
<223>  S. cerevisiae FAS1 (Accession No. NP_012739)

<400>  11

Met Asp Ala Tyr Ser Thr Arg Pro Leu Thr Leu Ser His Gly Ser Leu 
1               5                   10                  15      


Glu His Val Leu Leu Val Pro Thr Ala Ser Phe Phe Ile Ala Ser Gln 
            20                  25                  30          


Leu Gln Glu Gln Phe Asn Lys Ile Leu Pro Glu Pro Thr Glu Gly Phe 
        35                  40                  45              


Ala Ala Asp Asp Glu Pro Thr Thr Pro Ala Glu Leu Val Gly Lys Phe 
    50                  55                  60                  


Leu Gly Tyr Val Ser Ser Leu Val Glu Pro Ser Lys Val Gly Gln Phe 
65                  70                  75                  80  


Asp Gln Val Leu Asn Leu Cys Leu Thr Glu Phe Glu Asn Cys Tyr Leu 
                85                  90                  95      


Glu Gly Asn Asp Ile His Ala Leu Ala Ala Lys Leu Leu Gln Glu Asn 
            100                 105                 110         


Asp Thr Thr Leu Val Lys Thr Lys Glu Leu Ile Lys Asn Tyr Ile Thr 
        115                 120                 125             


Ala Arg Ile Met Ala Lys Arg Pro Phe Asp Lys Lys Ser Asn Ser Ala 
    130                 135                 140                 


Leu Phe Arg Ala Val Gly Glu Gly Asn Ala Gln Leu Val Ala Ile Phe 
145                 150                 155                 160 


Gly Gly Gln Gly Asn Thr Asp Asp Tyr Phe Glu Glu Leu Arg Asp Leu 
                165                 170                 175     


Tyr Gln Thr Tyr His Val Leu Val Gly Asp Leu Ile Lys Phe Ser Ala 
            180                 185                 190         


Glu Thr Leu Ser Glu Leu Ile Arg Thr Thr Leu Asp Ala Glu Lys Val 
        195                 200                 205             


Phe Thr Gln Gly Leu Asn Ile Leu Glu Trp Leu Glu Asn Pro Ser Asn 
    210                 215                 220                 


Thr Pro Asp Lys Asp Tyr Leu Leu Ser Ile Pro Ile Ser Cys Pro Leu 
225                 230                 235                 240 


Ile Gly Val Ile Gln Leu Ala His Tyr Val Val Thr Ala Lys Leu Leu 
                245                 250                 255     


Gly Phe Thr Pro Gly Glu Leu Arg Ser Tyr Leu Lys Gly Ala Thr Gly 
            260                 265                 270         


His Ser Gln Gly Leu Val Thr Ala Val Ala Ile Ala Glu Thr Asp Ser 
        275                 280                 285             


Trp Glu Ser Phe Phe Val Ser Val Arg Lys Ala Ile Thr Val Leu Phe 
    290                 295                 300                 


Phe Ile Gly Val Arg Cys Tyr Glu Ala Tyr Pro Asn Thr Ser Leu Pro 
305                 310                 315                 320 


Pro Ser Ile Leu Glu Asp Ser Leu Glu Asn Asn Glu Gly Val Pro Ser 
                325                 330                 335     


Pro Met Leu Ser Ile Ser Asn Leu Thr Gln Glu Gln Val Gln Asp Tyr 
            340                 345                 350         


Val Asn Lys Thr Asn Ser His Leu Pro Ala Gly Lys Gln Val Glu Ile 
        355                 360                 365             


Ser Leu Val Asn Gly Ala Lys Asn Leu Val Val Ser Gly Pro Pro Gln 
    370                 375                 380                 


Ser Leu Tyr Gly Leu Asn Leu Thr Leu Arg Lys Ala Lys Ala Pro Ser 
385                 390                 395                 400 


Gly Leu Asp Gln Ser Arg Ile Pro Phe Ser Glu Arg Lys Leu Lys Phe 
                405                 410                 415     


Ser Asn Arg Phe Leu Pro Val Ala Ser Pro Phe His Ser His Leu Leu 
            420                 425                 430         


Val Pro Ala Ser Asp Leu Ile Asn Lys Asp Leu Val Lys Asn Asn Val 
        435                 440                 445             


Ser Phe Asn Ala Lys Asp Ile Gln Ile Pro Val Tyr Asp Thr Phe Asp 
    450                 455                 460                 


Gly Ser Asp Leu Arg Val Leu Ser Gly Ser Ile Ser Glu Arg Ile Val 
465                 470                 475                 480 


Asp Cys Ile Ile Arg Leu Pro Val Lys Trp Glu Thr Thr Thr Gln Phe 
                485                 490                 495     


Lys Ala Thr His Ile Leu Asp Phe Gly Pro Gly Gly Ala Ser Gly Leu 
            500                 505                 510         


Gly Val Leu Thr His Arg Asn Lys Asp Gly Thr Gly Val Arg Val Ile 
        515                 520                 525             


Val Ala Gly Thr Leu Asp Ile Asn Pro Asp Asp Asp Tyr Gly Phe Lys 
    530                 535                 540                 


Gln Glu Ile Phe Asp Val Thr Ser Asn Gly Leu Lys Lys Asn Pro Asn 
545                 550                 555                 560 


Trp Leu Glu Glu Tyr His Pro Lys Leu Ile Lys Asn Lys Ser Gly Lys 
                565                 570                 575     


Ile Phe Val Glu Thr Lys Phe Ser Lys Leu Ile Gly Arg Pro Pro Leu 
            580                 585                 590         


Leu Val Pro Gly Met Thr Pro Cys Thr Val Ser Pro Asp Phe Val Ala 
        595                 600                 605             


Ala Thr Thr Asn Ala Gly Tyr Thr Ile Glu Leu Ala Gly Gly Gly Tyr 
    610                 615                 620                 


Phe Ser Ala Ala Gly Met Thr Ala Ala Ile Asp Ser Val Val Ser Gln 
625                 630                 635                 640 


Ile Glu Lys Gly Ser Thr Phe Gly Ile Asn Leu Ile Tyr Val Asn Pro 
                645                 650                 655     


Phe Met Leu Gln Trp Gly Ile Pro Leu Ile Lys Glu Leu Arg Ser Lys 
            660                 665                 670         


Gly Tyr Pro Ile Gln Phe Leu Thr Ile Gly Ala Gly Val Pro Ser Leu 
        675                 680                 685             


Glu Val Ala Ser Glu Tyr Ile Glu Thr Leu Gly Leu Lys Tyr Leu Gly 
    690                 695                 700                 


Leu Lys Pro Gly Ser Ile Asp Ala Ile Ser Gln Val Ile Asn Ile Ala 
705                 710                 715                 720 


Lys Ala His Pro Asn Phe Pro Ile Ala Leu Gln Trp Thr Gly Gly Arg 
                725                 730                 735     


Gly Gly Gly His His Ser Phe Glu Asp Ala His Thr Pro Met Leu Gln 
            740                 745                 750         


Met Tyr Ser Lys Ile Arg Arg His Pro Asn Ile Met Leu Ile Phe Gly 
        755                 760                 765             


Ser Gly Phe Gly Ser Ala Asp Asp Thr Tyr Pro Tyr Leu Thr Gly Glu 
    770                 775                 780                 


Trp Ser Thr Lys Phe Asp Tyr Pro Pro Met Pro Phe Asp Gly Phe Leu 
785                 790                 795                 800 


Phe Gly Ser Arg Val Met Ile Ala Lys Glu Val Lys Thr Ser Pro Asp 
                805                 810                 815     


Ala Lys Lys Cys Ile Ala Ala Cys Thr Gly Val Pro Asp Asp Lys Trp 
            820                 825                 830         


Glu Gln Thr Tyr Lys Lys Pro Thr Gly Gly Ile Val Thr Val Arg Ser 
        835                 840                 845             


Glu Met Gly Glu Pro Ile His Lys Ile Ala Thr Arg Gly Val Met Leu 
    850                 855                 860                 


Trp Lys Glu Phe Asp Glu Thr Ile Phe Asn Leu Pro Lys Asn Lys Leu 
865                 870                 875                 880 


Val Pro Thr Leu Glu Ala Lys Arg Asp Tyr Ile Ile Ser Arg Leu Asn 
                885                 890                 895     


Ala Asp Phe Gln Lys Pro Trp Phe Ala Thr Val Asn Gly Gln Ala Arg 
            900                 905                 910         


Asp Leu Ala Thr Met Thr Tyr Glu Glu Val Ala Lys Arg Leu Val Glu 
        915                 920                 925             


Leu Met Phe Ile Arg Ser Thr Asn Ser Trp Phe Asp Val Thr Trp Arg 
    930                 935                 940                 


Thr Phe Thr Gly Asp Phe Leu Arg Arg Val Glu Glu Arg Phe Thr Lys 
945                 950                 955                 960 


Ser Lys Thr Leu Ser Leu Ile Gln Ser Tyr Ser Leu Leu Asp Lys Pro 
                965                 970                 975     


Asp Glu Ala Ile Glu Lys Val Phe Asn Ala Tyr Pro Ala Ala Arg Glu 
            980                 985                 990         


Gln Phe Leu Asn Ala Gln Asp Ile  Asp His Phe Leu Ser  Met Cys Gln 
        995                 1000                 1005             


Asn Pro  Met Gln Lys Pro Val  Pro Phe Val Pro Val  Leu Asp Arg 
    1010                 1015                 1020             


Arg Phe  Glu Ile Phe Phe Lys  Lys Asp Ser Leu Trp  Gln Ser Glu 
    1025                 1030                 1035             


His Leu  Glu Ala Val Val Asp  Gln Asp Val Gln Arg  Thr Cys Ile 
    1040                 1045                 1050             


Leu His  Gly Pro Val Ala Ala  Gln Phe Thr Lys Val  Ile Asp Glu 
    1055                 1060                 1065             


Pro Ile  Lys Ser Ile Met Asp  Gly Ile His Asp Gly  His Ile Lys 
    1070                 1075                 1080             


Lys Leu  Leu His Gln Tyr Tyr  Gly Asp Asp Glu Ser  Lys Ile Pro 
    1085                 1090                 1095             


Ala Val  Glu Tyr Phe Gly Gly  Glu Ser Pro Val Asp  Val Gln Ser 
    1100                 1105                 1110             


Gln Val  Asp Ser Ser Ser Val  Ser Glu Asp Ser Ala  Val Phe Lys 
    1115                 1120                 1125             


Ala Thr  Ser Ser Thr Asp Glu  Glu Ser Trp Phe Lys  Ala Leu Ala 
    1130                 1135                 1140             


Gly Ser  Glu Ile Asn Trp Arg  His Ala Ser Phe Leu  Cys Ser Phe 
    1145                 1150                 1155             


Ile Thr  Gln Asp Lys Met Phe  Val Ser Asn Pro Ile  Arg Lys Val 
    1160                 1165                 1170             


Phe Lys  Pro Ser Gln Gly Met  Val Val Glu Ile Ser  Asn Gly Asn 
    1175                 1180                 1185             


Thr Ser  Ser Lys Thr Val Val  Thr Leu Ser Glu Pro  Val Gln Gly 
    1190                 1195                 1200             


Glu Leu  Lys Pro Thr Val Ile  Leu Lys Leu Leu Lys  Glu Asn Ile 
    1205                 1210                 1215             


Ile Gln  Met Glu Met Ile Glu  Asn Arg Thr Met Asp  Gly Lys Pro 
    1220                 1225                 1230             


Val Ser  Leu Pro Leu Leu Tyr  Asn Phe Asn Pro Asp  Asn Gly Phe 
    1235                 1240                 1245             


Ala Pro  Ile Ser Glu Val Met  Glu Asp Arg Asn Gln  Arg Ile Lys 
    1250                 1255                 1260             


Glu Met  Tyr Trp Lys Leu Trp  Ile Asp Glu Pro Phe  Asn Leu Asp 
    1265                 1270                 1275             


Phe Asp  Pro Arg Asp Val Ile  Lys Gly Lys Asp Phe  Glu Ile Thr 
    1280                 1285                 1290             


Ala Lys  Glu Val Tyr Asp Phe  Thr His Ala Val Gly  Asn Asn Cys 
    1295                 1300                 1305             


Glu Asp  Phe Val Ser Arg Pro  Asp Arg Thr Met Leu  Ala Pro Met 
    1310                 1315                 1320             


Asp Phe  Ala Ile Val Val Gly  Trp Arg Ala Ile Ile  Lys Ala Ile 
    1325                 1330                 1335             


Phe Pro  Asn Thr Val Asp Gly  Asp Leu Leu Lys Leu  Val His Leu 
    1340                 1345                 1350             


Ser Asn  Gly Tyr Lys Met Ile  Pro Gly Ala Lys Pro  Leu Gln Val 
    1355                 1360                 1365             


Gly Asp  Val Val Ser Thr Thr  Ala Val Ile Glu Ser  Val Val Asn 
    1370                 1375                 1380             


Gln Pro  Thr Gly Lys Ile Val  Asp Val Val Gly Thr  Leu Ser Arg 
    1385                 1390                 1395             


Asn Gly  Lys Pro Val Met Glu  Val Thr Ser Ser Phe  Phe Tyr Arg 
    1400                 1405                 1410             


Gly Asn  Tyr Thr Asp Phe Glu  Asn Thr Phe Gln Lys  Thr Val Glu 
    1415                 1420                 1425             


Pro Val  Tyr Gln Met His Ile  Lys Thr Ser Lys Asp  Ile Ala Val 
    1430                 1435                 1440             


Leu Arg  Ser Lys Glu Trp Phe  Gln Leu Asp Asp Glu  Asp Phe Asp 
    1445                 1450                 1455             


Leu Leu  Asn Lys Thr Leu Thr  Phe Glu Thr Glu Thr  Glu Val Thr 
    1460                 1465                 1470             


Phe Lys  Asn Ala Asn Ile Phe  Ser Ser Val Lys Cys  Phe Gly Pro 
    1475                 1480                 1485             


Ile Lys  Val Glu Leu Pro Thr  Lys Glu Thr Val Glu  Ile Gly Ile 
    1490                 1495                 1500             


Val Asp  Tyr Glu Ala Gly Ala  Ser His Gly Asn Pro  Val Val Asp 
    1505                 1510                 1515             


Phe Leu  Lys Arg Asn Gly Ser  Thr Leu Glu Gln Lys  Val Asn Leu 
    1520                 1525                 1530             


Glu Asn  Pro Ile Pro Ile Ala  Val Leu Asp Ser Tyr  Thr Pro Ser 
    1535                 1540                 1545             


Thr Asn  Glu Pro Tyr Ala Arg  Val Ser Gly Asp Leu  Asn Pro Ile 
    1550                 1555                 1560             


His Val  Ser Arg His Phe Ala  Ser Tyr Ala Asn Leu  Pro Gly Thr 
    1565                 1570                 1575             


Ile Thr  His Gly Met Phe Ser  Ser Ala Ser Val Arg  Ala Leu Ile 
    1580                 1585                 1590             


Glu Asn  Trp Ala Ala Asp Ser  Val Ser Ser Arg Val  Arg Gly Tyr 
    1595                 1600                 1605             


Thr Cys  Gln Phe Val Asp Met  Val Leu Pro Asn Thr  Ala Leu Lys 
    1610                 1615                 1620             


Thr Ser  Ile Gln His Val Gly  Met Ile Asn Gly Arg  Lys Leu Ile 
    1625                 1630                 1635             


Lys Phe  Glu Thr Arg Asn Glu  Asp Asp Val Val Val  Leu Thr Gly 
    1640                 1645                 1650             


Glu Ala  Glu Ile Glu Gln Pro  Val Thr Thr Phe Val  Phe Thr Gly 
    1655                 1660                 1665             


Gln Gly  Ser Gln Glu Gln Gly  Met Gly Met Asp Leu  Tyr Lys Thr 
    1670                 1675                 1680             


Ser Lys  Ala Ala Gln Asp Val  Trp Asn Arg Ala Asp  Asn His Phe 
    1685                 1690                 1695             


Lys Asp  Thr Tyr Gly Phe Ser  Ile Leu Asp Ile Val  Ile Asn Asn 
    1700                 1705                 1710             


Pro Val  Asn Leu Thr Ile His  Phe Gly Gly Glu Lys  Gly Lys Arg 
    1715                 1720                 1725             


Ile Arg  Glu Asn Tyr Ser Ala  Met Ile Phe Glu Thr  Ile Val Asp 
    1730                 1735                 1740             


Gly Lys  Leu Lys Thr Glu Lys  Ile Phe Lys Glu Ile  Asn Glu His 
    1745                 1750                 1755             


Ser Thr  Ser Tyr Thr Phe Arg  Ser Glu Lys Gly Leu  Leu Ser Ala 
    1760                 1765                 1770             


Thr Gln  Phe Thr Gln Pro Ala  Leu Thr Leu Met Glu  Lys Ala Ala 
    1775                 1780                 1785             


Phe Glu  Asp Leu Lys Ser Lys  Gly Leu Ile Pro Ala  Asp Ala Thr 
    1790                 1795                 1800             


Phe Ala  Gly His Ser Leu Gly  Glu Tyr Ala Ala Leu  Ala Ser Leu 
    1805                 1810                 1815             


Ala Asp  Val Met Ser Ile Glu  Ser Leu Val Glu Val  Val Phe Tyr 
    1820                 1825                 1830             


Arg Gly  Met Thr Met Gln Val  Ala Val Pro Arg Asp  Glu Leu Gly 
    1835                 1840                 1845             


Arg Ser  Asn Tyr Gly Met Ile  Ala Ile Asn Pro Gly  Arg Val Ala 
    1850                 1855                 1860             


Ala Ser  Phe Ser Gln Glu Ala  Leu Gln Tyr Val Val  Glu Arg Val 
    1865                 1870                 1875             


Gly Lys  Arg Thr Gly Trp Leu  Val Glu Ile Val Asn  Tyr Asn Val 
    1880                 1885                 1890             


Glu Asn  Gln Gln Tyr Val Ala  Ala Gly Asp Leu Arg  Ala Leu Asp 
    1895                 1900                 1905             


Thr Val  Thr Asn Val Leu Asn  Phe Ile Lys Leu Gln  Lys Ile Asp 
    1910                 1915                 1920             


Ile Ile  Glu Leu Gln Lys Ser  Leu Ser Leu Glu Glu  Val Glu Gly 
    1925                 1930                 1935             


His Leu  Phe Glu Ile Ile Asp  Glu Ala Ser Lys Lys  Ser Ala Val 
    1940                 1945                 1950             


Lys Pro  Arg Pro Leu Lys Leu  Glu Arg Gly Phe Ala  Cys Ile Pro 
    1955                 1960                 1965             


Leu Val  Gly Ile Ser Val Pro  Phe His Ser Thr Tyr  Leu Met Asn 
    1970                 1975                 1980             


Gly Val  Lys Pro Phe Lys Ser  Phe Leu Lys Lys Asn  Ile Ile Lys 
    1985                 1990                 1995             


Glu Asn  Val Lys Val Ala Arg  Leu Ala Gly Lys Tyr  Ile Pro Asn 
    2000                 2005                 2010             


Leu Thr  Ala Lys Pro Phe Gln  Val Thr Lys Glu Tyr  Phe Gln Asp 
    2015                 2020                 2025             


Val Tyr  Asp Leu Thr Gly Ser  Glu Pro Ile Lys Glu  Ile Ile Asp 
    2030                 2035                 2040             


Asn Trp  Glu Lys Tyr Glu Gln  Ser 
    2045                 2050     


<210>  12
<211>  1887
<212>  PRT
<213>  Saccharomyces cerevisiae


<220>
<221>  MISC_FEATURE
<223>  S. cerevisiae FAS2 (Accession No. NP_015093)

<400>  12

Met Lys Pro Glu Val Glu Gln Glu Leu Ala His Ile Leu Leu Thr Glu 
1               5                   10                  15      


Leu Leu Ala Tyr Gln Phe Ala Ser Pro Val Arg Trp Ile Glu Thr Gln 
            20                  25                  30          


Asp Val Phe Leu Lys Asp Phe Asn Thr Glu Arg Val Val Glu Ile Gly 
        35                  40                  45              


Pro Ser Pro Thr Leu Ala Gly Met Ala Gln Arg Thr Leu Lys Asn Lys 
    50                  55                  60                  


Tyr Glu Ser Tyr Asp Ala Ala Leu Ser Leu His Arg Glu Ile Leu Cys 
65                  70                  75                  80  


Tyr Ser Lys Asp Ala Lys Glu Ile Tyr Tyr Thr Pro Asp Pro Ser Glu 
                85                  90                  95      


Leu Ala Ala Lys Glu Glu Pro Ala Lys Glu Glu Ala Pro Ala Pro Thr 
            100                 105                 110         


Pro Ala Ala Ser Ala Pro Ala Pro Ala Ala Ala Ala Pro Ala Pro Val 
        115                 120                 125             


Ala Ala Ala Ala Pro Ala Ala Ala Ala Ala Glu Ile Ala Asp Glu Pro 
    130                 135                 140                 


Val Lys Ala Ser Leu Leu Leu His Val Leu Val Ala His Lys Leu Lys 
145                 150                 155                 160 


Lys Ser Leu Asp Ser Ile Pro Met Ser Lys Thr Ile Lys Asp Leu Val 
                165                 170                 175     


Gly Gly Lys Ser Thr Val Gln Asn Glu Ile Leu Gly Asp Leu Gly Lys 
            180                 185                 190         


Glu Phe Gly Thr Thr Pro Glu Lys Pro Glu Glu Thr Pro Leu Glu Glu 
        195                 200                 205             


Leu Ala Glu Thr Phe Gln Asp Thr Phe Ser Gly Ala Leu Gly Lys Gln 
    210                 215                 220                 


Ser Ser Ser Leu Leu Ser Arg Leu Ile Ser Ser Lys Met Pro Gly Gly 
225                 230                 235                 240 


Phe Thr Ile Thr Val Ala Arg Lys Tyr Leu Gln Thr Arg Trp Gly Leu 
                245                 250                 255     


Pro Ser Gly Arg Gln Asp Gly Val Leu Leu Val Ala Leu Ser Asn Glu 
            260                 265                 270         


Pro Ala Ala Arg Leu Gly Ser Glu Ala Asp Ala Lys Ala Phe Leu Asp 
        275                 280                 285             


Ser Met Ala Gln Lys Tyr Ala Ser Ile Val Gly Val Asp Leu Ser Ser 
    290                 295                 300                 


Ala Ala Ser Ala Ser Gly Ala Ala Gly Ala Gly Ala Ala Ala Gly Ala 
305                 310                 315                 320 


Ala Met Ile Asp Ala Gly Ala Leu Glu Glu Ile Thr Lys Asp His Lys 
                325                 330                 335     


Val Leu Ala Arg Gln Gln Leu Gln Val Leu Ala Arg Tyr Leu Lys Met 
            340                 345                 350         


Asp Leu Asp Asn Gly Glu Arg Lys Phe Leu Lys Glu Lys Asp Thr Val 
        355                 360                 365             


Ala Glu Leu Gln Ala Gln Leu Asp Tyr Leu Asn Ala Glu Leu Gly Glu 
    370                 375                 380                 


Phe Phe Val Asn Gly Val Ala Thr Ser Phe Ser Arg Lys Lys Ala Arg 
385                 390                 395                 400 


Thr Phe Asp Ser Ser Trp Asn Trp Ala Lys Gln Ser Leu Leu Ser Leu 
                405                 410                 415     


Tyr Phe Glu Ile Ile His Gly Val Leu Lys Asn Val Asp Arg Glu Val 
            420                 425                 430         


Val Ser Glu Ala Ile Asn Ile Met Asn Arg Ser Asn Asp Ala Leu Ile 
        435                 440                 445             


Lys Phe Met Glu Tyr His Ile Ser Asn Thr Asp Glu Thr Lys Gly Glu 
    450                 455                 460                 


Asn Tyr Gln Leu Val Lys Thr Leu Gly Glu Gln Leu Ile Glu Asn Cys 
465                 470                 475                 480 


Lys Gln Val Leu Asp Val Asp Pro Val Tyr Lys Asp Val Ala Lys Pro 
                485                 490                 495     


Thr Gly Pro Lys Thr Ala Ile Asp Lys Asn Gly Asn Ile Thr Tyr Ser 
            500                 505                 510         


Glu Glu Pro Arg Glu Lys Val Arg Lys Leu Ser Gln Tyr Val Gln Glu 
        515                 520                 525             


Met Ala Leu Gly Gly Pro Ile Thr Lys Glu Ser Gln Pro Thr Ile Glu 
    530                 535                 540                 


Glu Asp Leu Thr Arg Val Tyr Lys Ala Ile Ser Ala Gln Ala Asp Lys 
545                 550                 555                 560 


Gln Asp Ile Ser Ser Ser Thr Arg Val Glu Phe Glu Lys Leu Tyr Ser 
                565                 570                 575     


Asp Leu Met Lys Phe Leu Glu Ser Ser Lys Glu Ile Asp Pro Ser Gln 
            580                 585                 590         


Thr Thr Gln Leu Ala Gly Met Asp Val Glu Asp Ala Leu Asp Lys Asp 
        595                 600                 605             


Ser Thr Lys Glu Val Ala Ser Leu Pro Asn Lys Ser Thr Ile Ser Lys 
    610                 615                 620                 


Thr Val Ser Ser Thr Ile Pro Arg Glu Thr Ile Pro Phe Leu His Leu 
625                 630                 635                 640 


Arg Lys Lys Thr Pro Ala Gly Asp Trp Lys Tyr Asp Arg Gln Leu Ser 
                645                 650                 655     


Ser Leu Phe Leu Asp Gly Leu Glu Lys Ala Ala Phe Asn Gly Val Thr 
            660                 665                 670         


Phe Lys Asp Lys Tyr Val Leu Ile Thr Gly Ala Gly Lys Gly Ser Ile 
        675                 680                 685             


Gly Ala Glu Val Leu Gln Gly Leu Leu Gln Gly Gly Ala Lys Val Val 
    690                 695                 700                 


Val Thr Thr Ser Arg Phe Ser Lys Gln Val Thr Asp Tyr Tyr Gln Ser 
705                 710                 715                 720 


Ile Tyr Ala Lys Tyr Gly Ala Lys Gly Ser Thr Leu Ile Val Val Pro 
                725                 730                 735     


Phe Asn Gln Gly Ser Lys Gln Asp Val Glu Ala Leu Ile Glu Phe Ile 
            740                 745                 750         


Tyr Asp Thr Glu Lys Asn Gly Gly Leu Gly Trp Asp Leu Asp Ala Ile 
        755                 760                 765             


Ile Pro Phe Ala Ala Ile Pro Glu Gln Gly Ile Glu Leu Glu His Ile 
    770                 775                 780                 


Asp Ser Lys Ser Glu Phe Ala His Arg Ile Met Leu Thr Asn Ile Leu 
785                 790                 795                 800 


Arg Met Met Gly Cys Val Lys Lys Gln Lys Ser Ala Arg Gly Ile Glu 
                805                 810                 815     


Thr Arg Pro Ala Gln Val Ile Leu Pro Met Ser Pro Asn His Gly Thr 
            820                 825                 830         


Phe Gly Gly Asp Gly Met Tyr Ser Glu Ser Lys Leu Ser Leu Glu Thr 
        835                 840                 845             


Leu Phe Asn Arg Trp His Ser Glu Ser Trp Ala Asn Gln Leu Thr Val 
    850                 855                 860                 


Cys Gly Ala Ile Ile Gly Trp Thr Arg Gly Thr Gly Leu Met Ser Ala 
865                 870                 875                 880 


Asn Asn Ile Ile Ala Glu Gly Ile Glu Lys Met Gly Val Arg Thr Phe 
                885                 890                 895     


Ser Gln Lys Glu Met Ala Phe Asn Leu Leu Gly Leu Leu Thr Pro Glu 
            900                 905                 910         


Val Val Glu Leu Cys Gln Lys Ser Pro Val Met Ala Asp Leu Asn Gly 
        915                 920                 925             


Gly Leu Gln Phe Val Pro Glu Leu Lys Glu Phe Thr Ala Lys Leu Arg 
    930                 935                 940                 


Lys Glu Leu Val Glu Thr Ser Glu Val Arg Lys Ala Val Ser Ile Glu 
945                 950                 955                 960 


Thr Ala Leu Glu His Lys Val Val Asn Gly Asn Ser Ala Asp Ala Ala 
                965                 970                 975     


Tyr Ala Gln Val Glu Ile Gln Pro Arg Ala Asn Ile Gln Leu Asp Phe 
            980                 985                 990         


Pro Glu Leu Lys Pro Tyr Lys Gln  Val Lys Gln Ile Ala  Pro Ala Glu 
        995                 1000                 1005             


Leu Glu  Gly Leu Leu Asp Leu  Glu Arg Val Ile Val  Val Thr Gly 
    1010                 1015                 1020             


Phe Ala  Glu Val Gly Pro Trp  Gly Ser Ala Arg Thr  Arg Trp Glu 
    1025                 1030                 1035             


Met Glu  Ala Phe Gly Glu Phe  Ser Leu Glu Gly Cys  Val Glu Met 
    1040                 1045                 1050             


Ala Trp  Ile Met Gly Phe Ile  Ser Tyr His Asn Gly  Asn Leu Lys 
    1055                 1060                 1065             


Gly Arg  Pro Tyr Thr Gly Trp  Val Asp Ser Lys Thr  Lys Glu Pro 
    1070                 1075                 1080             


Val Asp  Asp Lys Asp Val Lys  Ala Lys Tyr Glu Thr  Ser Ile Leu 
    1085                 1090                 1095             


Glu His  Ser Gly Ile Arg Leu  Ile Glu Pro Glu Leu  Phe Asn Gly 
    1100                 1105                 1110             


Tyr Asn  Pro Glu Lys Lys Glu  Met Ile Gln Glu Val  Ile Val Glu 
    1115                 1120                 1125             


Glu Asp  Leu Glu Pro Phe Glu  Ala Ser Lys Glu Thr  Ala Glu Gln 
    1130                 1135                 1140             


Phe Lys  His Gln His Gly Asp  Lys Val Asp Ile Phe  Glu Ile Pro 
    1145                 1150                 1155             


Glu Thr  Gly Glu Tyr Ser Val  Lys Leu Leu Lys Gly  Ala Thr Leu 
    1160                 1165                 1170             


Tyr Ile  Pro Lys Ala Leu Arg  Phe Asp Arg Leu Val  Ala Gly Gln 
    1175                 1180                 1185             


Ile Pro  Thr Gly Trp Asn Ala  Lys Thr Tyr Gly Ile  Ser Asp Asp 
    1190                 1195                 1200             


Ile Ile  Ser Gln Val Asp Pro  Ile Thr Leu Phe Val  Leu Val Ser 
    1205                 1210                 1215             


Val Val  Glu Ala Phe Ile Ala  Ser Gly Ile Thr Asp  Pro Tyr Glu 
    1220                 1225                 1230             


Met Tyr  Lys Tyr Val His Val  Ser Glu Val Gly Asn  Cys Ser Gly 
    1235                 1240                 1245             


Ser Gly  Met Gly Gly Val Ser  Ala Leu Arg Gly Met  Phe Lys Asp 
    1250                 1255                 1260             


Arg Phe  Lys Asp Glu Pro Val  Gln Asn Asp Ile Leu  Gln Glu Ser 
    1265                 1270                 1275             


Phe Ile  Asn Thr Met Ser Ala  Trp Val Asn Met Leu  Leu Ile Ser 
    1280                 1285                 1290             


Ser Ser  Gly Pro Ile Lys Thr  Pro Val Gly Ala Cys  Ala Thr Ser 
    1295                 1300                 1305             


Val Glu  Ser Val Asp Ile Gly  Val Glu Thr Ile Leu  Ser Gly Lys 
    1310                 1315                 1320             


Ala Arg  Ile Cys Ile Val Gly  Gly Tyr Asp Asp Phe  Gln Glu Glu 
    1325                 1330                 1335             


Gly Ser  Phe Glu Phe Gly Asn  Met Lys Ala Thr Ser  Asn Thr Leu 
    1340                 1345                 1350             


Glu Glu  Phe Glu His Gly Arg  Thr Pro Ala Glu Met  Ser Arg Pro 
    1355                 1360                 1365             


Ala Thr  Thr Thr Arg Asn Gly  Phe Met Glu Ala Gln  Gly Ala Gly 
    1370                 1375                 1380             


Ile Gln  Ile Ile Met Gln Ala  Asp Leu Ala Leu Lys  Met Gly Val 
    1385                 1390                 1395             


Pro Ile  Tyr Gly Ile Val Ala  Met Ala Ala Thr Ala  Thr Asp Lys 
    1400                 1405                 1410             


Ile Gly  Arg Ser Val Pro Ala  Pro Gly Lys Gly Ile  Leu Thr Thr 
    1415                 1420                 1425             


Ala Arg  Glu His His Ser Ser  Val Lys Tyr Ala Ser  Pro Asn Leu 
    1430                 1435                 1440             


Asn Met  Lys Tyr Arg Lys Arg  Gln Leu Val Thr Arg  Glu Ala Gln 
    1445                 1450                 1455             


Ile Lys  Asp Trp Val Glu Asn  Glu Leu Glu Ala Leu  Lys Leu Glu 
    1460                 1465                 1470             


Ala Glu  Glu Ile Pro Ser Glu  Asp Gln Asn Glu Phe  Leu Leu Glu 
    1475                 1480                 1485             


Arg Thr  Arg Glu Ile His Asn  Glu Ala Glu Ser Gln  Leu Arg Ala 
    1490                 1495                 1500             


Ala Gln  Gln Gln Trp Gly Asn  Asp Phe Tyr Lys Arg  Asp Pro Arg 
    1505                 1510                 1515             


Ile Ala  Pro Leu Arg Gly Ala  Leu Ala Thr Tyr Gly  Leu Thr Ile 
    1520                 1525                 1530             


Asp Asp  Leu Gly Val Ala Ser  Phe His Gly Thr Ser  Thr Lys Ala 
    1535                 1540                 1545             


Asn Asp  Lys Asn Glu Ser Ala  Thr Ile Asn Glu Met  Met Lys His 
    1550                 1555                 1560             


Leu Gly  Arg Ser Glu Gly Asn  Pro Val Ile Gly Val  Phe Gln Lys 
    1565                 1570                 1575             


Phe Leu  Thr Gly His Pro Lys  Gly Ala Ala Gly Ala  Trp Met Met 
    1580                 1585                 1590             


Asn Gly  Ala Leu Gln Ile Leu  Asn Ser Gly Ile Ile  Pro Gly Asn 
    1595                 1600                 1605             


Arg Asn  Ala Asp Asn Val Asp  Lys Ile Leu Glu Gln  Phe Glu Tyr 
    1610                 1615                 1620             


Val Leu  Tyr Pro Ser Lys Thr  Leu Lys Thr Asp Gly  Val Arg Ala 
    1625                 1630                 1635             


Val Ser  Ile Thr Ser Phe Gly  Phe Gly Gln Lys Gly  Gly Gln Ala 
    1640                 1645                 1650             


Ile Val  Val His Pro Asp Tyr  Leu Tyr Gly Ala Ile  Thr Glu Asp 
    1655                 1660                 1665             


Arg Tyr  Asn Glu Tyr Val Ala  Lys Val Ser Ala Arg  Glu Lys Ser 
    1670                 1675                 1680             


Ala Tyr  Lys Phe Phe His Asn  Gly Met Ile Tyr Asn  Lys Leu Phe 
    1685                 1690                 1695             


Val Ser  Lys Glu His Ala Pro  Tyr Thr Asp Glu Leu  Glu Glu Asp 
    1700                 1705                 1710             


Val Tyr  Leu Asp Pro Leu Ala  Arg Val Ser Lys Asp  Lys Lys Ser 
    1715                 1720                 1725             


Gly Ser  Leu Thr Phe Asn Ser  Lys Asn Ile Gln Ser  Lys Asp Ser 
    1730                 1735                 1740             


Tyr Ile  Asn Ala Asn Thr Ile  Glu Thr Ala Lys Met  Ile Glu Asn 
    1745                 1750                 1755             


Met Thr  Lys Glu Lys Val Ser  Asn Gly Gly Val Gly  Val Asp Val 
    1760                 1765                 1770             


Glu Leu  Ile Thr Ser Ile Asn  Val Glu Asn Asp Thr  Phe Ile Glu 
    1775                 1780                 1785             


Arg Asn  Phe Thr Pro Gln Glu  Ile Glu Tyr Cys Ser  Ala Gln Pro 
    1790                 1795                 1800             


Ser Val  Gln Ser Ser Phe Ala  Gly Thr Trp Ser Ala  Lys Glu Ala 
    1805                 1810                 1815             


Val Phe  Lys Ser Leu Gly Val  Lys Ser Leu Gly Gly  Gly Ala Ala 
    1820                 1825                 1830             


Leu Lys  Asp Ile Glu Ile Val  Arg Val Asn Lys Asn  Ala Pro Ala 
    1835                 1840                 1845             


Val Glu  Leu His Gly Asn Ala  Lys Lys Ala Ala Glu  Glu Ala Gly 
    1850                 1855                 1860             


Val Thr  Asp Val Lys Val Ser  Ile Ser His Asp Asp  Leu Gln Ala 
    1865                 1870                 1875             


Val Ala  Val Ala Val Ser Thr  Lys Lys 
    1880                 1885         


<210>  13
<211>  460
<212>  PRT
<213>  Saccharomyces cerevisiae


<220>
<221>  MISC_FEATURE
<223>  S.cerevisiae CIT2 (Accession No. NP_009931)

<400>  13

Met Thr Val Pro Tyr Leu Asn Ser Asn Arg Asn Val Ala Ser Tyr Leu 
1               5                   10                  15      


Gln Ser Asn Ser Ser Gln Glu Lys Thr Leu Lys Glu Arg Phe Ser Glu 
            20                  25                  30          


Ile Tyr Pro Ile His Ala Gln Asp Val Arg Gln Phe Val Lys Glu His 
        35                  40                  45              


Gly Lys Thr Lys Ile Ser Asp Val Leu Leu Glu Gln Val Tyr Gly Gly 
    50                  55                  60                  


Met Arg Gly Ile Pro Gly Ser Val Trp Glu Gly Ser Val Leu Asp Pro 
65                  70                  75                  80  


Glu Asp Gly Ile Arg Phe Arg Gly Arg Thr Ile Ala Asp Ile Gln Lys 
                85                  90                  95      


Asp Leu Pro Lys Ala Lys Gly Ser Ser Gln Pro Leu Pro Glu Ala Leu 
            100                 105                 110         


Phe Trp Leu Leu Leu Thr Gly Glu Val Pro Thr Gln Ala Gln Val Glu 
        115                 120                 125             


Asn Leu Ser Ala Asp Leu Met Ser Arg Ser Glu Leu Pro Ser His Val 
    130                 135                 140                 


Val Gln Leu Leu Asp Asn Leu Pro Lys Asp Leu His Pro Met Ala Gln 
145                 150                 155                 160 


Phe Ser Ile Ala Val Thr Ala Leu Glu Ser Glu Ser Lys Phe Ala Lys 
                165                 170                 175     


Ala Tyr Ala Gln Gly Ile Ser Lys Gln Asp Tyr Trp Ser Tyr Thr Phe 
            180                 185                 190         


Glu Asp Ser Leu Asp Leu Leu Gly Lys Leu Pro Val Ile Ala Ala Lys 
        195                 200                 205             


Ile Tyr Arg Asn Val Phe Lys Asp Gly Lys Met Gly Glu Val Asp Pro 
    210                 215                 220                 


Asn Ala Asp Tyr Ala Lys Asn Leu Val Asn Leu Ile Gly Ser Lys Asp 
225                 230                 235                 240 


Glu Asp Phe Val Asp Leu Met Arg Leu Tyr Leu Thr Ile His Ser Asp 
                245                 250                 255     


His Glu Gly Gly Asn Val Ser Ala His Thr Ser His Leu Val Gly Ser 
            260                 265                 270         


Ala Leu Ser Ser Pro Tyr Leu Ser Leu Ala Ser Gly Leu Asn Gly Leu 
        275                 280                 285             


Ala Gly Pro Leu His Gly Arg Ala Asn Gln Glu Val Leu Glu Trp Leu 
    290                 295                 300                 


Phe Ala Leu Lys Glu Glu Val Asn Asp Asp Tyr Ser Lys Asp Thr Ile 
305                 310                 315                 320 


Glu Lys Tyr Leu Trp Asp Thr Leu Asn Ser Gly Arg Val Ile Pro Gly 
                325                 330                 335     


Tyr Gly His Ala Val Leu Arg Lys Thr Asp Pro Arg Tyr Met Ala Gln 
            340                 345                 350         


Arg Lys Phe Ala Met Asp His Phe Pro Asp Tyr Glu Leu Phe Lys Leu 
        355                 360                 365             


Val Ser Ser Ile Tyr Glu Val Ala Pro Gly Val Leu Thr Glu His Gly 
    370                 375                 380                 


Lys Thr Lys Asn Pro Trp Pro Asn Val Asp Ala His Ser Gly Val Leu 
385                 390                 395                 400 


Leu Gln Tyr Tyr Gly Leu Lys Glu Ser Ser Phe Tyr Thr Val Leu Phe 
                405                 410                 415     


Gly Val Ser Arg Ala Phe Gly Ile Leu Ala Gln Leu Ile Thr Asp Arg 
            420                 425                 430         


Ala Ile Gly Ala Ser Ile Glu Arg Pro Lys Ser Tyr Ser Thr Glu Lys 
        435                 440                 445             


Tyr Lys Glu Leu Val Lys Asn Ile Glu Ser Lys Leu 
    450                 455                 460 


<210>  14
<211>  557
<212>  PRT
<213>  Saccharomyces cerevisiae


<220>
<221>  MISC_FEATURE
<223>  S. cerevisiae ILC1 (Accession No. NP_010987)

<400>  14

Met Pro Ile Pro Val Gly Asn Thr Lys Asn Asp Phe Ala Ala Leu Gln 
1               5                   10                  15      


Ala Lys Leu Asp Ala Asp Ala Ala Glu Ile Glu Lys Trp Trp Ser Asp 
            20                  25                  30          


Ser Arg Trp Ser Lys Thr Lys Arg Asn Tyr Ser Ala Arg Asp Ile Ala 
        35                  40                  45              


Val Arg Arg Gly Thr Phe Pro Pro Ile Glu Tyr Pro Ser Ser Val Met 
    50                  55                  60                  


Ala Arg Lys Leu Phe Lys Val Leu Glu Lys His His Asn Glu Gly Thr 
65                  70                  75                  80  


Val Ser Lys Thr Phe Gly Ala Leu Asp Pro Val Gln Ile Ser Gln Met 
                85                  90                  95      


Ala Lys Tyr Leu Asp Thr Ile Tyr Ile Ser Gly Trp Gln Cys Ser Ser 
            100                 105                 110         


Thr Ala Ser Thr Ser Asn Glu Pro Gly Pro Asp Leu Ala Asp Tyr Pro 
        115                 120                 125             


Met Asp Thr Val Pro Asn Lys Val Glu His Leu Phe Lys Ala Gln Leu 
    130                 135                 140                 


Phe His Asp Arg Lys Gln Leu Glu Ala Arg Ser Lys Ala Lys Ser Gln 
145                 150                 155                 160 


Glu Glu Leu Asp Glu Met Gly Ala Pro Ile Asp Tyr Leu Thr Pro Ile 
                165                 170                 175     


Val Ala Asp Ala Asp Ala Gly His Gly Gly Leu Thr Ala Val Phe Lys 
            180                 185                 190         


Leu Thr Lys Met Phe Ile Glu Arg Gly Ala Ala Gly Ile His Met Glu 
        195                 200                 205             


Asp Gln Thr Ser Thr Asn Lys Lys Cys Gly His Met Ala Gly Arg Cys 
    210                 215                 220                 


Val Ile Pro Val Gln Glu His Val Asn Arg Leu Val Thr Ile Arg Met 
225                 230                 235                 240 


Cys Ala Asp Ile Met His Ser Asp Leu Ile Val Val Ala Arg Thr Asp 
                245                 250                 255     


Ser Glu Ala Ala Thr Leu Ile Ser Ser Thr Ile Asp Thr Arg Asp His 
            260                 265                 270         


Tyr Phe Ile Val Gly Ala Thr Asn Pro Asn Ile Glu Pro Phe Ala Glu 
        275                 280                 285             


Val Leu Asn Asp Ala Ile Met Ser Gly Ala Ser Gly Gln Glu Leu Ala 
    290                 295                 300                 


Asp Ile Glu Gln Lys Trp Cys Arg Asp Ala Gly Leu Lys Leu Phe His 
305                 310                 315                 320 


Glu Ala Val Ile Asp Glu Ile Glu Arg Ser Ala Leu Ser Asn Lys Gln 
                325                 330                 335     


Glu Leu Ile Lys Lys Phe Thr Ser Lys Val Gly Pro Leu Thr Glu Thr 
            340                 345                 350         


Ser His Arg Glu Ala Lys Lys Leu Ala Lys Glu Ile Leu Gly His Glu 
        355                 360                 365             


Ile Phe Phe Asp Trp Glu Leu Pro Arg Val Arg Glu Gly Leu Tyr Arg 
    370                 375                 380                 


Tyr Arg Gly Gly Thr Gln Cys Ser Ile Met Arg Ala Arg Ala Phe Ala 
385                 390                 395                 400 


Pro Tyr Ala Asp Leu Val Trp Met Glu Ser Asn Tyr Pro Asp Phe Gln 
                405                 410                 415     


Gln Ala Lys Glu Phe Ala Glu Gly Val Lys Glu Lys Phe Pro Asp Gln 
            420                 425                 430         


Trp Leu Ala Tyr Asn Leu Ser Pro Ser Phe Asn Trp Pro Lys Ala Met 
        435                 440                 445             


Ser Val Asp Glu Gln His Thr Phe Ile Gln Arg Leu Gly Asp Leu Gly 
    450                 455                 460                 


Tyr Ile Trp Gln Phe Ile Thr Leu Ala Gly Leu His Thr Asn Ala Leu 
465                 470                 475                 480 


Ala Val His Asn Phe Ser Arg Asp Phe Ala Lys Asp Gly Met Lys Ala 
                485                 490                 495     


Tyr Ala Gln Asn Val Gln Gln Arg Glu Met Asp Asp Gly Val Asp Val 
            500                 505                 510         


Leu Lys His Gln Lys Trp Ser Gly Ala Glu Tyr Ile Asp Gly Leu Leu 
        515                 520                 525             


Lys Leu Ala Gln Gly Gly Val Ser Ala Thr Ala Ala Met Gly Thr Gly 
    530                 535                 540                 


Val Thr Glu Asp Gln Phe Lys Glu Asn Gly Val Lys Lys 
545                 550                 555         


<210>  15
<211>  554
<212>  PRT
<213>  Saccharomyces cerevisiae


<220>
<221>  MISC_FEATURE
<223>  S. cerevisiae MLS1 (Accession NO. NP_014282)

<400>  15

Met Val Lys Val Ser Leu Asp Asn Val Lys Leu Leu Val Asp Val Asp 
1               5                   10                  15      


Lys Glu Pro Phe Phe Lys Pro Ser Ser Thr Thr Val Gly Asp Ile Leu 
            20                  25                  30          


Thr Lys Asp Ala Leu Glu Phe Ile Val Leu Leu His Arg Thr Phe Asn 
        35                  40                  45              


Asn Lys Arg Lys Gln Leu Leu Glu Asn Arg Gln Val Val Gln Lys Lys 
    50                  55                  60                  


Leu Asp Ser Gly Ser Tyr His Leu Asp Phe Leu Pro Glu Thr Ala Asn 
65                  70                  75                  80  


Ile Arg Asn Asp Pro Thr Trp Gln Gly Pro Ile Leu Ala Pro Gly Leu 
                85                  90                  95      


Ile Asn Arg Ser Thr Glu Ile Thr Gly Pro Pro Leu Arg Asn Met Leu 
            100                 105                 110         


Ile Asn Ala Leu Asn Ala Pro Val Asn Thr Tyr Met Thr Asp Phe Glu 
        115                 120                 125             


Asp Ser Ala Ser Pro Thr Trp Asn Asn Met Val Tyr Gly Gln Val Asn 
    130                 135                 140                 


Leu Tyr Asp Ala Ile Arg Asn Gln Ile Asp Phe Asp Thr Pro Arg Lys 
145                 150                 155                 160 


Ser Tyr Lys Leu Asn Gly Asn Val Ala Asn Leu Pro Thr Ile Ile Val 
                165                 170                 175     


Arg Pro Arg Gly Trp His Met Val Glu Lys His Leu Tyr Val Asp Asp 
            180                 185                 190         


Glu Pro Ile Ser Ala Ser Ile Phe Asp Phe Gly Leu Tyr Phe Tyr His 
        195                 200                 205             


Asn Ala Lys Glu Leu Ile Lys Leu Gly Lys Gly Pro Tyr Phe Tyr Leu 
    210                 215                 220                 


Pro Lys Met Glu His His Leu Glu Ala Lys Leu Trp Asn Asp Val Phe 
225                 230                 235                 240 


Cys Val Ala Gln Asp Tyr Ile Gly Ile Pro Arg Gly Thr Ile Arg Ala 
                245                 250                 255     


Thr Val Leu Ile Glu Thr Leu Pro Ala Ala Phe Gln Met Glu Glu Ile 
            260                 265                 270         


Ile Tyr Gln Leu Arg Gln His Ser Ser Gly Leu Asn Cys Gly Arg Trp 
        275                 280                 285             


Asp Tyr Ile Phe Ser Thr Ile Lys Arg Leu Arg Asn Asp Pro Asn His 
    290                 295                 300                 


Ile Leu Pro Asn Arg Asn Gln Val Thr Met Thr Ser Pro Phe Met Asp 
305                 310                 315                 320 


Ala Tyr Val Lys Arg Leu Ile Asn Thr Cys His Arg Arg Gly Val His 
                325                 330                 335     


Ala Met Gly Gly Met Ala Ala Gln Ile Pro Ile Lys Asp Asp Pro Ala 
            340                 345                 350         


Ala Asn Glu Lys Ala Met Thr Lys Val Arg Asn Asp Lys Ile Arg Glu 
        355                 360                 365             


Leu Thr Asn Gly His Asp Gly Ser Trp Val Ala His Pro Ala Leu Ala 
    370                 375                 380                 


Pro Ile Cys Asn Glu Val Phe Ile Asn Met Gly Thr Pro Asn Gln Ile 
385                 390                 395                 400 


Tyr Phe Ile Pro Glu Asn Val Val Thr Ala Ala Asn Leu Leu Glu Thr 
                405                 410                 415     


Lys Ile Pro Asn Gly Glu Ile Thr Thr Glu Gly Ile Val Gln Asn Leu 
            420                 425                 430         


Asp Ile Gly Leu Gln Tyr Met Glu Ala Trp Leu Arg Gly Ser Gly Cys 
        435                 440                 445             


Val Pro Ile Asn Asn Leu Met Glu Asp Ala Ala Thr Ala Glu Val Ser 
    450                 455                 460                 


Arg Cys Gln Leu Tyr Gln Trp Val Lys His Gly Val Thr Leu Lys Asp 
465                 470                 475                 480 


Thr Gly Glu Lys Val Thr Pro Glu Leu Thr Glu Lys Ile Leu Lys Glu 
                485                 490                 495     


Gln Val Glu Arg Leu Ser Lys Ala Ser Pro Leu Gly Asp Lys Asn Lys 
            500                 505                 510         


Phe Ala Leu Ala Ala Lys Tyr Phe Leu Pro Glu Ile Arg Gly Glu Lys 
        515                 520                 525             


Phe Ser Glu Phe Leu Thr Thr Leu Leu Tyr Asp Glu Ile Val Ser Thr 
    530                 535                 540                 


Lys Ala Thr Pro Thr Asp Leu Ser Lys Leu 
545                 550                 


<210>  16
<211>  343
<212>  PRT
<213>  Saccharomyces cerevisiae


<220>
<221>  MISC_FEATURE
<223>  S. cerevisiae MDH3 (Accession No. NP_010205)

<400>  16

Met Val Lys Val Ala Ile Leu Gly Ala Ser Gly Gly Val Gly Gln Pro 
1               5                   10                  15      


Leu Ser Leu Leu Leu Lys Leu Ser Pro Tyr Val Ser Glu Leu Ala Leu 
            20                  25                  30          


Tyr Asp Ile Arg Ala Ala Glu Gly Ile Gly Lys Asp Leu Ser His Ile 
        35                  40                  45              


Asn Thr Asn Ser Ser Cys Val Gly Tyr Asp Lys Asp Ser Ile Glu Asn 
    50                  55                  60                  


Thr Leu Ser Asn Ala Gln Val Val Leu Ile Pro Ala Gly Val Pro Arg 
65                  70                  75                  80  


Lys Pro Gly Leu Thr Arg Asp Asp Leu Phe Lys Met Asn Ala Gly Ile 
                85                  90                  95      


Val Lys Ser Leu Val Thr Ala Val Gly Lys Phe Ala Pro Asn Ala Arg 
            100                 105                 110         


Ile Leu Val Ile Ser Asn Pro Val Asn Ser Leu Val Pro Ile Ala Val 
        115                 120                 125             


Glu Thr Leu Lys Lys Met Gly Lys Phe Lys Pro Gly Asn Val Met Gly 
    130                 135                 140                 


Val Thr Asn Leu Asp Leu Val Arg Ala Glu Thr Phe Leu Val Asp Tyr 
145                 150                 155                 160 


Leu Met Leu Lys Asn Pro Lys Ile Gly Gln Glu Gln Asp Lys Thr Thr 
                165                 170                 175     


Met His Arg Lys Val Thr Val Ile Gly Gly His Ser Gly Glu Thr Ile 
            180                 185                 190         


Ile Pro Ile Ile Thr Asp Lys Ser Leu Val Phe Gln Leu Asp Lys Gln 
        195                 200                 205             


Tyr Glu His Phe Ile His Arg Val Gln Phe Gly Gly Asp Glu Ile Val 
    210                 215                 220                 


Lys Ala Lys Gln Gly Ala Gly Ser Ala Thr Leu Ser Met Ala Phe Ala 
225                 230                 235                 240 


Gly Ala Lys Phe Ala Glu Glu Val Leu Arg Ser Phe His Asn Glu Lys 
                245                 250                 255     


Pro Glu Thr Glu Ser Leu Ser Ala Phe Val Tyr Leu Pro Gly Leu Lys 
            260                 265                 270         


Asn Gly Lys Lys Ala Gln Gln Leu Val Gly Asp Asn Ser Ile Glu Tyr 
        275                 280                 285             


Phe Ser Leu Pro Ile Val Leu Arg Asn Gly Ser Val Val Ser Ile Asp 
    290                 295                 300                 


Thr Ser Val Leu Glu Lys Leu Ser Pro Arg Glu Glu Gln Leu Val Asn 
305                 310                 315                 320 


Thr Ala Val Lys Glu Leu Arg Lys Asn Ile Glu Lys Gly Lys Ser Phe 
                325                 330                 335     


Ile Leu Asp Ser Ser Lys Leu 
            340             


<210>  17
<211>  309
<212>  PRT
<213>  Saccharomyces cerevisiae


<220>
<221>  MISC_FEATURE
<223>  S.cerevisiae HAP2

<400>  17

Met Ala Ser Ser Ser His Asn Pro Val Ile Leu Leu Lys Arg Ile Leu 
1               5                   10                  15      


Ser Leu Thr Glu Ser Ser Pro Phe Ile Leu Cys Leu Asp Ser Ile Ala 
            20                  25                  30          


Gln Thr Ser Tyr Lys Leu Ile Gln Glu Phe Val His Gln Ser Lys Ser 
        35                  40                  45              


Lys Gly Asn Glu Tyr Pro Ile Val Tyr Ile Ser Phe Glu Thr Val Asn 
    50                  55                  60                  


Lys Pro Ser Tyr Cys Thr Gln Phe Ile Asp Ala Thr Gln Met Asp Phe 
65                  70                  75                  80  


Val His Leu Val Lys Gln Ile Ile Ser Tyr Leu Pro Ala Ala Thr Ala 
                85                  90                  95      


Thr Gln Ala Lys Lys His Met Val Ile Ile Asp Ser Leu Asn Tyr Ile 
            100                 105                 110         


Ser Thr Glu Tyr Ile Thr Arg Phe Leu Ser Glu Ile Ala Ser Pro His 
        115                 120                 125             


Cys Thr Met Val Ala Thr Tyr His Lys Asp Ile Lys Asp Glu Asn Arg 
    130                 135                 140                 


Thr Val Ile Pro Asp Trp Asn Asn Asn Tyr Pro Asp Lys Leu Thr Leu 
145                 150                 155                 160 


Leu Gln Phe Met Ala Thr Thr Ile Val Asp Ile Asp Val Val Leu Thr 
                165                 170                 175     


Gly Thr Leu Asp Thr Glu Glu Val Ser Glu Leu Leu Asn Glu Phe Arg 
            180                 185                 190         


Ile Pro Arg Gly Leu Asn Asn Asp Ile Phe Gln Leu Arg Leu Val Asn 
        195                 200                 205             


Lys Arg Lys Ser Gly Arg Ser Leu Glu Tyr Asp Phe Ile Val Asn Ser 
    210                 215                 220                 


Asn Thr His Glu Tyr Glu Leu Leu Ser Thr Thr Lys Gln Glu Glu Glu 
225                 230                 235                 240 


Ser Ser Ser Asn Gly Leu Glu Thr Pro Glu Met Leu Gln Gly Leu Thr 
                245                 250                 255     


Thr Phe Asn Leu Gly Thr Ser Asn Lys Gln Lys Leu Ala Lys Asp Gln 
            260                 265                 270         


Val Ala Leu Pro Phe Leu Glu Ala Gln Ser Phe Gly Gln Gly Gly Ala 
        275                 280                 285             


Ile Val Tyr Glu Tyr Glu Lys Asp Asp Asp Tyr Asp Glu Glu Asp Pro 
    290                 295                 300                 


Tyr Glu Asp Pro Phe 
305                 


<210>  18
<211>  144
<212>  PRT
<213>  Saccharomyces cerevisiae


<220>
<221>  MISC_FEATURE
<223>  S.cerevisiae HAP3

<400>  18

Met Asn Thr Asn Glu Ser Glu His Val Ser Thr Ser Pro Glu Asp Thr 
1               5                   10                  15      


Gln Glu Asn Gly Gly Asn Ala Ser Ser Ser Gly Ser Leu Gln Gln Ile 
            20                  25                  30          


Ser Thr Leu Arg Glu Gln Asp Arg Trp Leu Pro Ile Asn Asn Val Ala 
        35                  40                  45              


Arg Leu Met Lys Asn Thr Leu Pro Pro Ser Ala Lys Val Ser Lys Asp 
    50                  55                  60                  


Ala Lys Glu Cys Met Gln Glu Cys Val Ser Glu Leu Ile Ser Phe Val 
65                  70                  75                  80  


Thr Ser Glu Ala Ser Asp Arg Cys Ala Ala Asp Lys Arg Lys Thr Ile 
                85                  90                  95      


Asn Gly Glu Asp Ile Leu Ile Ser Leu His Ala Leu Gly Phe Glu Asn 
            100                 105                 110         


Tyr Ala Glu Val Leu Lys Ile Tyr Leu Ala Lys Tyr Arg Gln Gln Gln 
        115                 120                 125             


Ala Leu Lys Asn Gln Leu Met Tyr Glu Gln Asp Asp Glu Glu Val Pro 
    130                 135                 140                 


<210>  19
<211>  554
<212>  PRT
<213>  Saccharomyces cerevisiae


<220>
<221>  MISC_FEATURE
<223>  S.cerevisiae HAP4

<400>  19

Met Thr Ala Lys Thr Phe Leu Leu Gln Ala Ser Ala Ser Arg Pro Arg 
1               5                   10                  15      


Ser Asn His Phe Lys Asn Glu His Asn Asn Ile Pro Leu Ala Pro Val 
            20                  25                  30          


Pro Ile Ala Pro Asn Thr Asn His His Asn Asn Ser Ser Leu Glu Phe 
        35                  40                  45              


Glu Asn Asp Gly Ser Lys Lys Lys Lys Lys Ser Ser Leu Val Val Arg 
    50                  55                  60                  


Thr Ser Lys His Trp Val Leu Pro Pro Arg Pro Arg Pro Gly Arg Arg 
65                  70                  75                  80  


Ser Ser Ser His Asn Thr Leu Pro Ala Asn Asn Thr Asn Asn Ile Leu 
                85                  90                  95      


Asn Val Gly Pro Asn Ser Arg Asn Ser Ser Asn Asn Asn Asn Asn Asn 
            100                 105                 110         


Asn Ile Ile Ser Asn Arg Lys Gln Ala Ser Lys Glu Lys Arg Lys Ile 
        115                 120                 125             


Pro Arg His Ile Gln Thr Ile Asp Glu Lys Leu Ile Asn Asp Ser Asn 
    130                 135                 140                 


Tyr Leu Ala Phe Leu Lys Phe Asp Asp Leu Glu Asn Glu Lys Phe His 
145                 150                 155                 160 


Ser Ser Ala Ser Ser Ile Ser Ser Pro Ser Tyr Ser Ser Pro Ser Phe 
                165                 170                 175     


Ser Ser Tyr Arg Asn Arg Lys Lys Ser Glu Phe Met Asp Asp Glu Ser 
            180                 185                 190         


Cys Thr Asp Val Glu Thr Ile Ala Ala His Asn Ser Leu Leu Thr Lys 
        195                 200                 205             


Asn His His Ile Asp Ser Ser Ser Asn Val His Ala Pro Pro Thr Lys 
    210                 215                 220                 


Lys Ser Lys Leu Asn Asp Phe Asp Leu Leu Ser Leu Ser Ser Thr Ser 
225                 230                 235                 240 


Ser Ser Ala Thr Pro Val Pro Gln Leu Thr Lys Asp Leu Asn Met Asn 
                245                 250                 255     


Leu Asn Phe His Lys Ile Pro His Lys Ala Ser Phe Pro Asp Ser Pro 
            260                 265                 270         


Ala Asp Phe Ser Pro Ala Asp Ser Val Ser Leu Ile Arg Asn His Ser 
        275                 280                 285             


Leu Pro Thr Asn Leu Gln Val Lys Asp Lys Ile Glu Asp Leu Asn Glu 
    290                 295                 300                 


Ile Lys Phe Phe Asn Asp Phe Glu Lys Leu Glu Phe Phe Asn Lys Tyr 
305                 310                 315                 320 


Ala Lys Val Asn Thr Asn Asn Asp Val Asn Glu Asn Asn Asp Leu Trp 
                325                 330                 335     


Asn Ser Tyr Leu Gln Ser Met Asp Asp Thr Thr Gly Lys Asn Ser Gly 
            340                 345                 350         


Asn Tyr Gln Gln Val Asp Asn Asp Asp Asn Met Ser Leu Leu Asn Leu 
        355                 360                 365             


Pro Ile Leu Glu Glu Thr Val Ser Ser Gly Gln Asp Asp Lys Val Glu 
    370                 375                 380                 


Pro Asp Glu Glu Asp Ile Trp Asn Tyr Leu Pro Ser Ser Ser Ser Gln 
385                 390                 395                 400 


Gln Glu Asp Ser Ser Arg Ala Leu Lys Lys Asn Thr Asn Ser Glu Lys 
                405                 410                 415     


Ala Asn Ile Gln Ala Lys Asn Asp Glu Thr Tyr Leu Phe Leu Gln Asp 
            420                 425                 430         


Gln Asp Glu Ser Ala Asp Ser His His His Asp Glu Leu Gly Ser Glu 
        435                 440                 445             


Ile Thr Leu Ala Asp Asn Lys Phe Ser Tyr Leu Pro Pro Thr Leu Glu 
    450                 455                 460                 


Glu Leu Met Glu Glu Gln Asp Cys Asn Asn Gly Arg Ser Phe Lys Asn 
465                 470                 475                 480 


Phe Met Phe Ser Asn Asp Thr Gly Ile Asp Gly Ser Ala Gly Thr Asp 
                485                 490                 495     


Asp Asp Tyr Thr Lys Val Leu Lys Ser Lys Lys Ile Ser Thr Ser Lys 
            500                 505                 510         


Ser Asn Ala Asn Leu Tyr Asp Leu Asn Asp Asn Asn Asn Asp Ala Thr 
        515                 520                 525             


Ala Thr Asn Glu Leu Asp Gln Ser Ser Phe Ile Asp Asp Leu Asp Glu 
    530                 535                 540                 


Asp Val Asp Phe Leu Lys Val Gln Val Phe 
545                 550                 


<210>  20
<211>  242
<212>  PRT
<213>  Saccharomyces cerevisiae


<220>
<221>  MISC_FEATURE
<223>  S.cerevisiae HAP5

<400>  20

Met Thr Asp Arg Asn Phe Ser Pro Gln Gln Gly Gln Gly Pro Gln Glu 
1               5                   10                  15      


Ser Leu Pro Glu Gly Pro Gln Pro Ser Thr Met Ile Gln Arg Glu Glu 
            20                  25                  30          


Met Asn Met Pro Arg Gln Tyr Ser Glu Gln Gln Gln Leu Gln Glu Asn 
        35                  40                  45              


Glu Gly Glu Gly Glu Asn Thr Arg Leu Pro Val Ser Glu Glu Glu Phe 
    50                  55                  60                  


Arg Met Val Gln Glu Leu Gln Ala Ile Gln Ala Gly His Asp Gln Ala 
65                  70                  75                  80  


Asn Leu Pro Pro Ser Gly Arg Gly Ser Leu Glu Gly Glu Asp Asn Gly 
                85                  90                  95      


Asn Ser Asp Gly Ala Asp Gly Glu Met Asp Glu Asp Asp Glu Glu Tyr 
            100                 105                 110         


Asp Val Phe Arg Asn Val Gly Gln Gly Leu Val Gly His Tyr Lys Glu 
        115                 120                 125             


Ile Met Ile Arg Tyr Trp Gln Glu Leu Ile Asn Glu Ile Glu Ser Thr 
    130                 135                 140                 


Asn Glu Pro Gly Ser Glu His Gln Asp Asp Phe Lys Ser His Ser Leu 
145                 150                 155                 160 


Pro Phe Ala Arg Ile Arg Lys Val Met Lys Thr Asp Glu Asp Val Lys 
                165                 170                 175     


Met Ile Ser Ala Glu Ala Pro Ile Ile Phe Ala Lys Ala Cys Glu Ile 
            180                 185                 190         


Phe Ile Thr Glu Leu Thr Met Arg Ala Trp Cys Val Ala Glu Arg Asn 
        195                 200                 205             


Lys Arg Arg Thr Leu Gln Lys Ala Asp Ile Ala Glu Ala Leu Gln Lys 
    210                 215                 220                 


Ser Asp Met Phe Asp Phe Leu Ile Asp Val Val Pro Arg Arg Pro Leu 
225                 230                 235                 240 


Pro Gln 
        


<210>  21
<211>  420
<212>  PRT
<213>  Saccharomyces cerevisiae


<220>
<221>  MISC_FEATURE
<223>  S. cerevisiae PDA1 (Accession No. NP_011105)

<400>  21

Met Leu Ala Ala Ser Phe Lys Arg Gln Pro Ser Gln Leu Val Arg Gly 
1               5                   10                  15      


Leu Gly Ala Val Leu Arg Thr Pro Thr Arg Ile Gly His Val Arg Thr 
            20                  25                  30          


Met Ala Thr Leu Lys Thr Thr Asp Lys Lys Ala Pro Glu Asp Ile Glu 
        35                  40                  45              


Gly Ser Asp Thr Val Gln Ile Glu Leu Pro Glu Ser Ser Phe Glu Ser 
    50                  55                  60                  


Tyr Met Leu Glu Pro Pro Asp Leu Ser Tyr Glu Thr Ser Lys Ala Thr 
65                  70                  75                  80  


Leu Leu Gln Met Tyr Lys Asp Met Val Ile Ile Arg Arg Met Glu Met 
                85                  90                  95      


Ala Cys Asp Ala Leu Tyr Lys Ala Lys Lys Ile Arg Gly Phe Cys His 
            100                 105                 110         


Leu Ser Val Gly Gln Glu Ala Ile Ala Val Gly Ile Glu Asn Ala Ile 
        115                 120                 125             


Thr Lys Leu Asp Ser Ile Ile Thr Ser Tyr Arg Cys His Gly Phe Thr 
    130                 135                 140                 


Phe Met Arg Gly Ala Ser Val Lys Ala Val Leu Ala Glu Leu Met Gly 
145                 150                 155                 160 


Arg Arg Ala Gly Val Ser Tyr Gly Lys Gly Gly Ser Met His Leu Tyr 
                165                 170                 175     


Ala Pro Gly Phe Tyr Gly Gly Asn Gly Ile Val Gly Ala Gln Val Pro 
            180                 185                 190         


Leu Gly Ala Gly Leu Ala Phe Ala His Gln Tyr Lys Asn Glu Asp Ala 
        195                 200                 205             


Cys Ser Phe Thr Leu Tyr Gly Asp Gly Ala Ser Asn Gln Gly Gln Val 
    210                 215                 220                 


Phe Glu Ser Phe Asn Met Ala Lys Leu Trp Asn Leu Pro Val Val Phe 
225                 230                 235                 240 


Cys Cys Glu Asn Asn Lys Tyr Gly Met Gly Thr Ala Ala Ser Arg Ser 
                245                 250                 255     


Ser Ala Met Thr Glu Tyr Phe Lys Arg Gly Gln Tyr Ile Pro Gly Leu 
            260                 265                 270         


Lys Val Asn Gly Met Asp Ile Leu Ala Val Tyr Gln Ala Ser Lys Phe 
        275                 280                 285             


Ala Lys Asp Trp Cys Leu Ser Gly Lys Gly Pro Leu Val Leu Glu Tyr 
    290                 295                 300                 


Glu Thr Tyr Arg Tyr Gly Gly His Ser Met Ser Asp Pro Gly Thr Thr 
305                 310                 315                 320 


Tyr Arg Thr Arg Asp Glu Ile Gln His Met Arg Ser Lys Asn Asp Pro 
                325                 330                 335     


Ile Ala Gly Leu Lys Met His Leu Ile Asp Leu Gly Ile Ala Thr Glu 
            340                 345                 350         


Ala Glu Val Lys Ala Tyr Asp Lys Ser Ala Arg Lys Tyr Val Asp Glu 
        355                 360                 365             


Gln Val Glu Leu Ala Asp Ala Ala Pro Pro Pro Glu Ala Lys Leu Ser 
    370                 375                 380                 


Ile Leu Phe Glu Asp Val Tyr Val Lys Gly Thr Glu Thr Pro Thr Leu 
385                 390                 395                 400 


Arg Gly Arg Ile Pro Glu Asp Thr Trp Asp Phe Lys Lys Gln Gly Phe 
                405                 410                 415     


Ala Ser Arg Asp 
            420 


<210>  22
<211>  366
<212>  PRT
<213>  Saccharomyces cerevisiae


<220>
<221>  MISC_FEATURE
<223>  S. cerevisiae PDB1 (Accession No. NP_009780)

<400>  22

Met Phe Ser Arg Leu Pro Thr Ser Leu Ala Arg Asn Val Ala Arg Arg 
1               5                   10                  15      


Ala Pro Thr Ser Phe Val Arg Pro Ser Ala Ala Ala Ala Ala Leu Arg 
            20                  25                  30          


Phe Ser Ser Thr Lys Thr Met Thr Val Arg Glu Ala Leu Asn Ser Ala 
        35                  40                  45              


Met Ala Glu Glu Leu Asp Arg Asp Asp Asp Val Phe Leu Ile Gly Glu 
    50                  55                  60                  


Glu Val Ala Gln Tyr Asn Gly Ala Tyr Lys Val Ser Lys Gly Leu Leu 
65                  70                  75                  80  


Asp Arg Phe Gly Glu Arg Arg Val Val Asp Thr Pro Ile Thr Glu Tyr 
                85                  90                  95      


Gly Phe Thr Gly Leu Ala Val Gly Ala Ala Leu Lys Gly Leu Lys Pro 
            100                 105                 110         


Ile Val Glu Phe Met Ser Phe Asn Phe Ser Met Gln Ala Ile Asp His 
        115                 120                 125             


Val Val Asn Ser Ala Ala Lys Thr His Tyr Met Ser Gly Gly Thr Gln 
    130                 135                 140                 


Lys Cys Gln Met Val Phe Arg Gly Pro Asn Gly Ala Ala Val Gly Val 
145                 150                 155                 160 


Gly Ala Gln His Ser Gln Asp Phe Ser Pro Trp Tyr Gly Ser Ile Pro 
                165                 170                 175     


Gly Leu Lys Val Leu Val Pro Tyr Ser Ala Glu Asp Ala Arg Gly Leu 
            180                 185                 190         


Leu Lys Ala Ala Ile Arg Asp Pro Asn Pro Val Val Phe Leu Glu Asn 
        195                 200                 205             


Glu Leu Leu Tyr Gly Glu Ser Phe Glu Ile Ser Glu Glu Ala Leu Ser 
    210                 215                 220                 


Pro Glu Phe Thr Leu Pro Tyr Lys Ala Lys Ile Glu Arg Glu Gly Thr 
225                 230                 235                 240 


Asp Ile Ser Ile Val Thr Tyr Thr Arg Asn Val Gln Phe Ser Leu Glu 
                245                 250                 255     


Ala Ala Glu Ile Leu Gln Lys Lys Tyr Gly Val Ser Ala Glu Val Ile 
            260                 265                 270         


Asn Leu Arg Ser Ile Arg Pro Leu Asp Thr Glu Ala Ile Ile Lys Thr 
        275                 280                 285             


Val Lys Lys Thr Asn His Leu Ile Thr Val Glu Ser Thr Phe Pro Ser 
    290                 295                 300                 


Phe Gly Val Gly Ala Glu Ile Val Ala Gln Val Met Glu Ser Glu Ala 
305                 310                 315                 320 


Phe Asp Tyr Leu Asp Ala Pro Ile Gln Arg Val Thr Gly Ala Asp Val 
                325                 330                 335     


Pro Thr Pro Tyr Ala Lys Glu Leu Glu Asp Phe Ala Phe Pro Asp Thr 
            340                 345                 350         


Pro Thr Ile Val Lys Ala Val Lys Glu Val Leu Ser Ile Glu 
        355                 360                 365     


<210>  23
<211>  482
<212>  PRT
<213>  Saccharomyces cerevisiae


<220>
<221>  MISC_FEATURE
<223>  S. cerevisiae LAT1 (Accession No. NP_014328)

<400>  23

Met Ser Ala Phe Val Arg Val Val Pro Arg Ile Ser Arg Ser Ser Val 
1               5                   10                  15      


Leu Thr Arg Ser Leu Arg Leu Gln Leu Arg Cys Tyr Ala Ser Tyr Pro 
            20                  25                  30          


Glu His Thr Ile Ile Gly Met Pro Ala Leu Ser Pro Thr Met Thr Gln 
        35                  40                  45              


Gly Asn Leu Ala Ala Trp Thr Lys Lys Glu Gly Asp Gln Leu Ser Pro 
    50                  55                  60                  


Gly Glu Val Ile Ala Glu Ile Glu Thr Asp Lys Ala Gln Met Asp Phe 
65                  70                  75                  80  


Glu Phe Gln Glu Asp Gly Tyr Leu Ala Lys Ile Leu Val Pro Glu Gly 
                85                  90                  95      


Thr Lys Asp Ile Pro Val Asn Lys Pro Ile Ala Val Tyr Val Glu Asp 
            100                 105                 110         


Lys Ala Asp Val Pro Ala Phe Lys Asp Phe Lys Leu Glu Asp Ser Gly 
        115                 120                 125             


Ser Asp Ser Lys Thr Ser Thr Lys Ala Gln Pro Ala Glu Pro Gln Ala 
    130                 135                 140                 


Glu Lys Lys Gln Glu Ala Pro Ala Glu Glu Thr Lys Thr Ser Ala Pro 
145                 150                 155                 160 


Glu Ala Lys Lys Ser Asp Val Ala Ala Pro Gln Gly Arg Ile Phe Ala 
                165                 170                 175     


Ser Pro Leu Ala Lys Thr Ile Ala Leu Glu Lys Gly Ile Ser Leu Lys 
            180                 185                 190         


Asp Val His Gly Thr Gly Pro Arg Gly Arg Ile Thr Lys Ala Asp Ile 
        195                 200                 205             


Glu Ser Tyr Leu Glu Lys Ser Ser Lys Gln Ser Ser Gln Thr Ser Gly 
    210                 215                 220                 


Ala Ala Ala Ala Thr Pro Ala Ala Ala Thr Ser Ser Thr Thr Ala Gly 
225                 230                 235                 240 


Ser Ala Pro Ser Pro Ser Ser Thr Ala Ser Tyr Glu Asp Val Pro Ile 
                245                 250                 255     


Ser Thr Met Arg Ser Ile Ile Gly Glu Arg Leu Leu Gln Ser Thr Gln 
            260                 265                 270         


Gly Ile Pro Ser Tyr Ile Val Ser Ser Lys Ile Ser Ile Ser Lys Leu 
        275                 280                 285             


Leu Lys Leu Arg Gln Ser Leu Asn Ala Thr Ala Asn Asp Lys Tyr Lys 
    290                 295                 300                 


Leu Ser Ile Asn Asp Leu Leu Val Lys Ala Ile Thr Val Ala Ala Lys 
305                 310                 315                 320 


Arg Val Pro Asp Ala Asn Ala Tyr Trp Leu Pro Asn Glu Asn Val Ile 
                325                 330                 335     


Arg Lys Phe Lys Asn Val Asp Val Ser Val Ala Val Ala Thr Pro Thr 
            340                 345                 350         


Gly Leu Leu Thr Pro Ile Val Lys Asn Cys Glu Ala Lys Gly Leu Ser 
        355                 360                 365             


Gln Ile Ser Asn Glu Ile Lys Glu Leu Val Lys Arg Ala Arg Ile Asn 
    370                 375                 380                 


Lys Leu Ala Pro Glu Glu Phe Gln Gly Gly Thr Ile Cys Ile Ser Asn 
385                 390                 395                 400 


Met Gly Met Asn Asn Ala Val Asn Met Phe Thr Ser Ile Ile Asn Pro 
                405                 410                 415     


Pro Gln Ser Thr Ile Leu Ala Ile Ala Thr Val Glu Arg Val Ala Val 
            420                 425                 430         


Glu Asp Ala Ala Ala Glu Asn Gly Phe Ser Phe Asp Asn Gln Val Thr 
        435                 440                 445             


Ile Thr Gly Thr Phe Asp His Arg Thr Ile Asp Gly Ala Lys Gly Ala 
    450                 455                 460                 


Glu Phe Met Lys Glu Leu Lys Thr Val Ile Glu Asn Pro Leu Glu Met 
465                 470                 475                 480 


Leu Leu 
        


<210>  24
<211>  499
<212>  PRT
<213>  Saccharomyces cerevisiae


<220>
<221>  MISC_FEATURE
<223>  S. cerevisiae LPD1 (Accession No. NP_116635)

<400>  24

Met Leu Arg Ile Arg Ser Leu Leu Asn Asn Lys Arg Ala Phe Ser Ser 
1               5                   10                  15      


Thr Val Arg Thr Leu Thr Ile Asn Lys Ser His Asp Val Val Ile Ile 
            20                  25                  30          


Gly Gly Gly Pro Ala Gly Tyr Val Ala Ala Ile Lys Ala Ala Gln Leu 
        35                  40                  45              


Gly Phe Asn Thr Ala Cys Val Glu Lys Arg Gly Lys Leu Gly Gly Thr 
    50                  55                  60                  


Cys Leu Asn Val Gly Cys Ile Pro Ser Lys Ala Leu Leu Asn Asn Ser 
65                  70                  75                  80  


His Leu Phe His Gln Met His Thr Glu Ala Gln Lys Arg Gly Ile Asp 
                85                  90                  95      


Val Asn Gly Asp Ile Lys Ile Asn Val Ala Asn Phe Gln Lys Ala Lys 
            100                 105                 110         


Asp Asp Ala Val Lys Gln Leu Thr Gly Gly Ile Glu Leu Leu Phe Lys 
        115                 120                 125             


Lys Asn Lys Val Thr Tyr Tyr Lys Gly Asn Gly Ser Phe Glu Asp Glu 
    130                 135                 140                 


Thr Lys Ile Arg Val Thr Pro Val Asp Gly Leu Glu Gly Thr Val Lys 
145                 150                 155                 160 


Glu Asp His Ile Leu Asp Val Lys Asn Ile Ile Val Ala Thr Gly Ser 
                165                 170                 175     


Glu Val Thr Pro Phe Pro Gly Ile Glu Ile Asp Glu Glu Lys Ile Val 
            180                 185                 190         


Ser Ser Thr Gly Ala Leu Ser Leu Lys Glu Ile Pro Lys Arg Leu Thr 
        195                 200                 205             


Ile Ile Gly Gly Gly Ile Ile Gly Leu Glu Met Gly Ser Val Tyr Ser 
    210                 215                 220                 


Arg Leu Gly Ser Lys Val Thr Val Val Glu Phe Gln Pro Gln Ile Gly 
225                 230                 235                 240 


Ala Ser Met Asp Gly Glu Val Ala Lys Ala Thr Gln Lys Phe Leu Lys 
                245                 250                 255     


Lys Gln Gly Leu Asp Phe Lys Leu Ser Thr Lys Val Ile Ser Ala Lys 
            260                 265                 270         


Arg Asn Asp Asp Lys Asn Val Val Glu Ile Val Val Glu Asp Thr Lys 
        275                 280                 285             


Thr Asn Lys Gln Glu Asn Leu Glu Ala Glu Val Leu Leu Val Ala Val 
    290                 295                 300                 


Gly Arg Arg Pro Tyr Ile Ala Gly Leu Gly Ala Glu Lys Ile Gly Leu 
305                 310                 315                 320 


Glu Val Asp Lys Arg Gly Arg Leu Val Ile Asp Asp Gln Phe Asn Ser 
                325                 330                 335     


Lys Phe Pro His Ile Lys Val Val Gly Asp Val Thr Phe Gly Pro Met 
            340                 345                 350         


Leu Ala His Lys Ala Glu Glu Glu Gly Ile Ala Ala Val Glu Met Leu 
        355                 360                 365             


Lys Thr Gly His Gly His Val Asn Tyr Asn Asn Ile Pro Ser Val Met 
    370                 375                 380                 


Tyr Ser His Pro Glu Val Ala Trp Val Gly Lys Thr Glu Glu Gln Leu 
385                 390                 395                 400 


Lys Glu Ala Gly Ile Asp Tyr Lys Ile Gly Lys Phe Pro Phe Ala Ala 
                405                 410                 415     


Asn Ser Arg Ala Lys Thr Asn Gln Asp Thr Glu Gly Phe Val Lys Ile 
            420                 425                 430         


Leu Ile Asp Ser Lys Thr Glu Arg Ile Leu Gly Ala His Ile Ile Gly 
        435                 440                 445             


Pro Asn Ala Gly Glu Met Ile Ala Glu Ala Gly Leu Ala Leu Glu Tyr 
    450                 455                 460                 


Gly Ala Ser Ala Glu Asp Val Ala Arg Val Cys His Ala His Pro Thr 
465                 470                 475                 480 


Leu Ser Glu Ala Phe Lys Glu Ala Asn Met Ala Ala Tyr Asp Lys Ala 
                485                 490                 495     


Ile His Cys 
            


<210>  25
<211>  410
<212>  PRT
<213>  Saccharomyces cerevisiae


<220>
<221>  MISC_FEATURE
<223>  S. cerevisiae PDX1 (Accession No. NP_011709)

<400>  25

Met Leu Ser Ala Ile Ser Lys Val Ser Thr Leu Lys Ser Cys Thr Arg 
1               5                   10                  15      


Tyr Leu Thr Lys Cys Asn Tyr His Ala Ser Ala Lys Leu Leu Ala Val 
            20                  25                  30          


Lys Thr Phe Ser Met Pro Ala Met Ser Pro Thr Met Glu Lys Gly Gly 
        35                  40                  45              


Ile Val Ser Trp Lys Tyr Lys Val Gly Glu Pro Phe Ser Ala Gly Asp 
    50                  55                  60                  


Val Ile Leu Glu Val Glu Thr Asp Lys Ser Gln Ile Asp Val Glu Ala 
65                  70                  75                  80  


Leu Asp Asp Gly Lys Leu Ala Lys Ile Leu Lys Asp Glu Gly Ser Lys 
                85                  90                  95      


Asp Val Asp Val Gly Glu Pro Ile Ala Tyr Ile Ala Asp Val Asp Asp 
            100                 105                 110         


Asp Leu Ala Thr Ile Lys Leu Pro Gln Glu Ala Asn Thr Ala Asn Ala 
        115                 120                 125             


Lys Ser Ile Glu Ile Lys Lys Pro Ser Ala Asp Ser Thr Glu Ala Thr 
    130                 135                 140                 


Gln Gln His Leu Lys Lys Ala Thr Val Thr Pro Ile Lys Thr Val Asp 
145                 150                 155                 160 


Gly Ser Gln Ala Asn Leu Glu Gln Thr Leu Leu Pro Ser Val Ser Leu 
                165                 170                 175     


Leu Leu Ala Glu Asn Asn Ile Ser Lys Gln Lys Ala Leu Lys Glu Ile 
            180                 185                 190         


Ala Pro Ser Gly Ser Asn Gly Arg Leu Leu Lys Gly Asp Val Leu Ala 
        195                 200                 205             


Tyr Leu Gly Lys Ile Pro Gln Asp Ser Val Asn Lys Val Thr Glu Phe 
    210                 215                 220                 


Ile Lys Lys Asn Glu Arg Leu Asp Leu Ser Asn Ile Lys Pro Ile Gln 
225                 230                 235                 240 


Leu Lys Pro Lys Ile Ala Glu Gln Ala Gln Thr Lys Ala Ala Asp Lys 
                245                 250                 255     


Pro Lys Ile Thr Pro Val Glu Phe Glu Glu Gln Leu Val Phe His Ala 
            260                 265                 270         


Pro Ala Ser Ile Pro Phe Asp Lys Leu Ser Glu Ser Leu Asn Ser Phe 
        275                 280                 285             


Met Lys Glu Ala Tyr Gln Phe Ser His Gly Thr Pro Leu Met Asp Thr 
    290                 295                 300                 


Asn Ser Lys Tyr Phe Asp Pro Ile Phe Glu Asp Leu Val Thr Leu Ser 
305                 310                 315                 320 


Pro Arg Glu Pro Arg Phe Lys Phe Ser Tyr Asp Leu Met Gln Ile Pro 
                325                 330                 335     


Lys Ala Asn Asn Met Gln Asp Thr Tyr Gly Gln Glu Asp Ile Phe Asp 
            340                 345                 350         


Leu Leu Thr Gly Ser Asp Ala Thr Ala Ser Ser Val Arg Pro Val Glu 
        355                 360                 365             


Lys Asn Leu Pro Glu Lys Asn Glu Tyr Ile Leu Ala Leu Asn Val Ser 
    370                 375                 380                 


Val Asn Asn Lys Lys Phe Asn Asp Ala Glu Ala Lys Ala Lys Arg Phe 
385                 390                 395                 400 


Leu Asp Tyr Val Arg Glu Leu Glu Ser Phe 
                405                 410 


<210>  26
<211>  130
<212>  PRT
<213>  Saccharomyces cerevisiae


<220>
<221>  MISC_FEATURE
<223>  S. cerevisiae MPC1 (FMP37) (Accession No. NP_011435)

<400>  26

Met Ser Gln Pro Val Gln Arg Ala Ala Ala Arg Ser Phe Leu Gln Lys 
1               5                   10                  15      


Tyr Ile Asn Lys Glu Thr Leu Lys Tyr Ile Phe Thr Thr His Phe Trp 
            20                  25                  30          


Gly Pro Val Ser Asn Phe Gly Ile Pro Ile Ala Ala Ile Tyr Asp Leu 
        35                  40                  45              


Lys Lys Asp Pro Thr Leu Ile Ser Gly Pro Met Thr Phe Ala Leu Val 
    50                  55                  60                  


Thr Tyr Ser Gly Val Phe Met Lys Tyr Ala Leu Ser Val Ser Pro Lys 
65                  70                  75                  80  


Asn Tyr Leu Leu Phe Gly Cys His Leu Ile Asn Glu Thr Ala Gln Leu 
                85                  90                  95      


Ala Gln Gly Tyr Arg Phe Leu Lys Tyr Thr Tyr Phe Thr Thr Asp Glu 
            100                 105                 110         


Glu Lys Lys Ala Leu Asp Lys Glu Trp Lys Glu Lys Glu Lys Thr Gly 
        115                 120                 125             


Lys Gln 
    130 


<210>  27
<211>  373
<212>  PRT
<213>  Saccharomyces cerevisiae


<220>
<221>  MISC_FEATURE
<223>  S. cerevisiae YIA6 (Accession No. NP_012260)

<400>  27

Met Thr Gln Thr Asp Asn Pro Val Pro Asn Cys Gly Leu Leu Pro Glu 
1               5                   10                  15      


Gln Gln Tyr Cys Ser Ala Asp His Glu Glu Pro Leu Leu Leu His Glu 
            20                  25                  30          


Glu Gln Leu Ile Phe Pro Asp His Ser Ser Gln Leu Ser Ser Ala Asp 
        35                  40                  45              


Ile Ile Glu Pro Ile Lys Met Asn Ser Ser Thr Glu Ser Ile Ile Gly 
    50                  55                  60                  


Thr Thr Leu Arg Lys Lys Trp Val Pro Leu Ser Ser Thr Gln Ile Thr 
65                  70                  75                  80  


Ala Leu Ser Gly Ala Phe Ala Gly Phe Leu Ser Gly Val Ala Val Cys 
                85                  90                  95      


Pro Leu Asp Val Ala Lys Thr Arg Leu Gln Ala Gln Gly Leu Gln Thr 
            100                 105                 110         


Arg Phe Glu Asn Pro Tyr Tyr Arg Gly Ile Met Gly Thr Leu Ser Thr 
        115                 120                 125             


Ile Val Arg Asp Glu Gly Pro Arg Gly Leu Tyr Lys Gly Leu Val Pro 
    130                 135                 140                 


Ile Val Leu Gly Tyr Phe Pro Thr Trp Met Ile Tyr Phe Ser Val Tyr 
145                 150                 155                 160 


Glu Phe Ser Lys Lys Phe Phe His Gly Ile Phe Pro Gln Phe Asp Phe 
                165                 170                 175     


Val Ala Gln Ser Cys Ala Ala Ile Thr Ala Gly Ala Ala Ser Thr Thr 
            180                 185                 190         


Leu Thr Asn Pro Ile Trp Val Val Lys Thr Arg Leu Met Leu Gln Ser 
        195                 200                 205             


Asn Leu Gly Glu His Pro Thr His Tyr Lys Gly Thr Phe Asp Ala Phe 
    210                 215                 220                 


Arg Lys Leu Phe Tyr Gln Glu Gly Phe Lys Ala Leu Tyr Ala Gly Leu 
225                 230                 235                 240 


Val Pro Ser Leu Leu Gly Leu Phe His Val Ala Ile His Phe Pro Ile 
                245                 250                 255     


Tyr Glu Asp Leu Lys Val Arg Phe His Cys Tyr Ser Arg Glu Asn Asn 
            260                 265                 270         


Thr Asn Ser Ile Asn Leu Gln Arg Leu Ile Met Ala Ser Ser Val Ser 
        275                 280                 285             


Lys Met Ile Ala Ser Ala Val Thr Tyr Pro His Glu Ile Leu Arg Thr 
    290                 295                 300                 


Arg Met Gln Leu Lys Ser Asp Ile Pro Asp Ser Ile Gln Arg Arg Leu 
305                 310                 315                 320 


Phe Pro Leu Ile Lys Ala Thr Tyr Ala Gln Glu Gly Leu Lys Gly Phe 
                325                 330                 335     


Tyr Ser Gly Phe Thr Thr Asn Leu Val Arg Thr Ile Pro Ala Ser Ala 
            340                 345                 350         


Ile Thr Leu Val Ser Phe Glu Tyr Phe Arg Asn Arg Leu Glu Asn Ile 
        355                 360                 365             


Ser Thr Met Val Ile 
    370             


<210>  28
<211>  335
<212>  PRT
<213>  Saccharomyces cerevisiae


<220>
<221>  MISC_FEATURE
<223>  S. cerevisiae YEA6 (Accession No. NP_010910)

<400>  28

Met Asn Asn Gly Asp Asn Lys Thr Thr Leu Glu Asn Ser Lys Asn Ala 
1               5                   10                  15      


Ser Leu Ala Asn Gly Asn Tyr Ala Ile Pro Thr Lys Leu Asn Arg Leu 
            20                  25                  30          


Lys Lys Asn Ala Asp Pro Arg Val Ala Ala Ile Ser Gly Ala Leu Ser 
        35                  40                  45              


Gly Ala Leu Ser Ala Met Leu Val Cys Pro Phe Asp Val Ala Lys Thr 
    50                  55                  60                  


Arg Leu Gln Ala Gln Gly Leu Gln Asn Met Thr His Gln Ser Gln His 
65                  70                  75                  80  


Tyr Lys Gly Phe Phe Gly Thr Phe Ala Thr Ile Phe Lys Asp Glu Gly 
                85                  90                  95      


Ala Ala Gly Leu Tyr Lys Gly Leu Gln Pro Thr Val Leu Gly Tyr Ile 
            100                 105                 110         


Pro Thr Leu Met Ile Tyr Phe Ser Val Tyr Asp Phe Cys Arg Lys Tyr 
        115                 120                 125             


Ser Val Asp Ile Phe Pro His Ser Pro Phe Leu Ser Asn Ala Ser Ser 
    130                 135                 140                 


Ala Ile Thr Ala Gly Ala Ile Ser Thr Val Ala Thr Asn Pro Ile Trp 
145                 150                 155                 160 


Val Val Lys Thr Arg Leu Met Leu Gln Thr Gly Ile Gly Lys Tyr Ser 
                165                 170                 175     


Thr His Tyr Lys Gly Thr Ile Asp Thr Phe Arg Lys Ile Ile Gln Gln 
            180                 185                 190         


Glu Gly Ala Lys Ala Leu Tyr Ala Gly Leu Val Pro Ala Leu Leu Gly 
        195                 200                 205             


Met Leu Asn Val Ala Ile Gln Phe Pro Leu Tyr Glu Asn Leu Lys Ile 
    210                 215                 220                 


Arg Phe Gly Tyr Ser Glu Ser Thr Asp Val Ser Thr Asp Val Thr Ser 
225                 230                 235                 240 


Ser Asn Phe Gln Lys Leu Ile Leu Ala Ser Met Leu Ser Lys Met Val 
                245                 250                 255     


Ala Ser Thr Val Thr Tyr Pro His Glu Ile Leu Arg Thr Arg Met Gln 
            260                 265                 270         


Leu Lys Ser Asp Leu Pro Asn Thr Val Gln Arg His Leu Leu Pro Leu 
        275                 280                 285             


Ile Lys Ile Thr Tyr Arg Gln Glu Gly Phe Ala Gly Phe Tyr Ser Gly 
    290                 295                 300                 


Phe Ala Thr Asn Leu Val Arg Thr Val Pro Ala Ala Val Val Thr Leu 
305                 310                 315                 320 


Val Ser Phe Glu Tyr Ser Lys Lys Tyr Leu Thr Thr Phe Phe Gln 
                325                 330                 335 


<210>  29
<211>  687
<212>  PRT
<213>  Saccharomyces cerevisiae


<220>
<221>  MISC_FEATURE
<223>  S. cerevisiae YAT1 (Accession No. NP_009420)

<400>  29

Met Pro Asn Leu Lys Arg Leu Pro Ile Pro Pro Leu Gln Asp Thr Leu 
1               5                   10                  15      


Asn Arg Tyr Leu Ala Arg Val Glu Pro Leu Gln Asp Glu Arg Gln Asn 
            20                  25                  30          


Arg Arg Thr Arg Arg Thr Val Leu Ser Ala Glu Asn Leu Asp Ala Leu 
        35                  40                  45              


Asn Thr Leu His Glu Arg Leu Leu Glu Tyr Asp Ala Arg Leu Ala Glu 
    50                  55                  60                  


Ser Asn Pro Glu Ser Ser Tyr Ile Glu Gln Phe Trp Tyr Asp Ala Tyr 
65                  70                  75                  80  


Leu Leu Tyr Asp Ala Thr Val Val Leu Asn Val Asn Pro Tyr Phe Gln 
                85                  90                  95      


Leu Gln Asp Asp Pro Thr Ile Lys Asp Thr Pro Glu Thr Ala Ala Gln 
            100                 105                 110         


Gly Pro Tyr Gly Ala His Thr Val Gln Val Arg Arg Ala Ala Arg Leu 
        115                 120                 125             


Thr Thr Ser Ile Leu Lys Phe Ile Arg Gln Ile Arg His Gly Thr Leu 
    130                 135                 140                 


Arg Thr Asp Thr Val Arg Gly Lys Thr Pro Leu Ser Met Asp Gln Tyr 
145                 150                 155                 160 


Glu Arg Leu Phe Gly Ser Ser Arg Ile Pro Pro Gly Pro Gly Glu Pro 
                165                 170                 175     


Ser Cys His Leu Gln Thr Asp Ala Thr Ser His His Val Val Ala Met 
            180                 185                 190         


Tyr Arg Gly Gln Phe Tyr Trp Phe Asp Val Leu Asp Thr Arg Asn Glu 
        195                 200                 205             


Pro Ile Phe Ala Thr Pro Glu Gln Leu Glu Trp Asn Leu Tyr Ser Ile 
    210                 215                 220                 


Ile Met Asp Ala Glu Ser Ala Gly Ser Gly Ser Ala Pro Phe Gly Val 
225                 230                 235                 240 


Phe Thr Thr Glu Ser Arg Arg Val Trp Ser Asn Ile Arg Asp Tyr Leu 
                245                 250                 255     


Phe His Ala Asp Asp Cys Thr Asn Trp Arg Asn Leu Lys Leu Ile Asp 
            260                 265                 270         


Ser Ala Leu Phe Val Val Cys Leu Asp Asp Val Ala Phe Ala Ala Asp 
        275                 280                 285             


Gln Gln Asp Glu Leu Thr Arg Ser Met Leu Cys Gly Thr Ser Thr Ile 
    290                 295                 300                 


Asn Leu Asp Pro His Gln His Gln Pro Pro Leu Asn Val Gln Thr Gly 
305                 310                 315                 320 


Thr Cys Leu Asn Arg Trp Tyr Asp Lys Leu Gln Leu Ile Val Thr Lys 
                325                 330                 335     


Asn Gly Lys Ala Gly Ile Asn Phe Glu His Thr Gly Val Asp Gly His 
            340                 345                 350         


Thr Val Leu Arg Leu Ala Thr Asp Ile Tyr Thr Asp Ser Ile Leu Ser 
        355                 360                 365             


Phe Ala Arg Gly Val Thr Lys Asn Val Val Asp Ile Phe Ser Asp Asp 
    370                 375                 380                 


Asp Gly Lys Pro Ser Ser Ser Ser Leu Ala Ser Ala Ala His Ser Ala 
385                 390                 395                 400 


Asn Leu Ile Thr Ile Pro Arg Lys Leu Glu Trp Arg Thr Asp Asn Phe 
                405                 410                 415     


Leu Gln Ser Ser Leu His Phe Ala Glu Thr Arg Ile Ser Asp Leu Ile 
            420                 425                 430         


Ser Gln Tyr Glu Phe Val Asn Leu Asp Phe Ser Asn Tyr Gly Ala Ser 
        435                 440                 445             


His Ile Lys Thr Val Phe Lys Cys Ser Pro Asp Ala Phe Val Gln Gln 
    450                 455                 460                 


Val Phe Gln Val Ala Tyr Phe Ala Leu Tyr Gly Arg Phe Glu Thr Val 
465                 470                 475                 480 


Tyr Glu Pro Ala Met Thr Lys Ala Phe Gln Asn Gly Arg Thr Glu Ala 
                485                 490                 495     


Ile Arg Ser Val Thr Gly Gln Ser Lys Leu Phe Val Lys Ser Leu Leu 
            500                 505                 510         


Asp Gln Asp Ala Ser Asp Ala Thr Lys Ile Gln Leu Leu His Asp Ala 
        515                 520                 525             


Cys Thr Ala His Ser Gln Ile Thr Arg Glu Cys Ser Gln Gly Leu Gly 
    530                 535                 540                 


Gln Asp Arg His Leu Tyr Ala Leu Tyr Cys Leu Trp Asn Gln Trp Tyr 
545                 550                 555                 560 


Lys Asp Lys Leu Glu Leu Pro Pro Ile Phe Arg Asp Lys Ser Trp Thr 
                565                 570                 575     


Thr Met Gln Asn Asn Val Leu Ser Thr Ser Asn Cys Gly Asn Pro Cys 
            580                 585                 590         


Leu Lys Ser Phe Gly Phe Gly Pro Val Thr Ala Asn Gly Phe Gly Ile 
        595                 600                 605             


Gly Tyr Ile Ile Arg Asp His Ser Val Ser Val Val Val Ser Ser Arg 
    610                 615                 620                 


His Arg Gln Thr Ala Arg Phe Ala Ser Leu Met Glu Lys Ser Leu Leu 
625                 630                 635                 640 


Glu Ile Asp Arg Ile Phe Lys Arg Gln Gln Ala Arg Ala Ala Lys Pro 
                645                 650                 655     


Ala Ala Arg Thr Thr Ala Ser Ala Asn Thr Lys Ser Glu Asp Met Lys 
            660                 665                 670         


Tyr Leu Leu Ser Gly Tyr Asp Tyr Phe Asp Val Ser Val Ser Gly 
        675                 680                 685         


<210>  30
<211>  923
<212>  PRT
<213>  Saccharomyces cerevisiae


<220>
<221>  MISC_FEATURE
<223>  S. cerevisiae YAT2 (Accession No. NP_010941)

<400>  30

Met Ser Ser Gly Ser Thr Ile Val Ser Ser Asp Lys Ser Gly Arg Thr 
1               5                   10                  15      


Phe Lys His Glu Glu Glu Leu Pro Lys Leu Pro Leu Pro Lys Leu Cys 
            20                  25                  30          


Asp Thr Leu Gln Arg Leu Lys Glu Ser Leu Glu Pro Leu Tyr Tyr Ala 
        35                  40                  45              


Asp Gly Tyr Tyr Gln His Pro Leu Asp Pro Glu Gln Ile Glu Lys Leu 
    50                  55                  60                  


Ser Ser Ile Ile Arg Asp Phe Glu Glu Asn Pro Val Ser Glu Lys Leu 
65                  70                  75                  80  


Gln Ser Lys Leu Gln Ser Tyr His Asp Thr Arg Asp Cys Tyr Leu Asp 
                85                  90                  95      


Glu Leu His Leu Asp Ile Asn Asn Gln Thr Ser Thr Arg Glu Ile Gln 
            100                 105                 110         


Asp Asp Val Leu Pro Arg Asn Pro Phe Leu Val Leu Ala Asp Asp Ala 
        115                 120                 125             


Leu Pro Asn Ile Thr Gln Ala Asp Arg Ser Ala Val Leu Val His Ser 
    130                 135                 140                 


Ala Ala Arg Phe Ile Ser Ala Leu Lys Gln Asp Leu Leu Pro Pro Asp 
145                 150                 155                 160 


Ile Asn Ala Thr Asn Gly Lys Pro Leu Ser Met Ala Pro Phe Leu Asn 
                165                 170                 175     


Leu Phe Gly Thr Thr Arg Ser Pro Val Phe Gln Arg Gly Glu Val Glu 
            180                 185                 190         


Asn Phe Asp Leu Asn Lys Pro Tyr Thr Ala Ser Asp Leu Glu Asp Pro 
        195                 200                 205             


Asp Tyr Ser Ser Asp Glu Asp Asp Asn Asp Glu Pro Thr Gln Lys Asp 
    210                 215                 220                 


Phe Asp Asp Arg Lys Arg Lys His Glu Glu Asp Ile Phe Thr Gly Asn 
225                 230                 235                 240 


Gly Ile Thr Ile Lys Arg His Pro Asp Ser Lys His Ile Leu Ile Ile 
                245                 250                 255     


Ser Arg Gly Gln Tyr Tyr Thr Leu Glu Val Leu Asp Ser Thr Asn Lys 
            260                 265                 270         


Ile Ile Tyr Thr Ala Ala Glu Leu Thr Thr Ile Phe Asn His Ile Ile 
        275                 280                 285             


Lys Asp Ser Ser Gly Ile Glu Lys Ser Thr Ala Leu Gly Ser Leu Thr 
    290                 295                 300                 


Ser His Ser Phe Arg Asn Trp Lys Tyr Ala Arg Lys Arg Leu Gln Lys 
305                 310                 315                 320 


Arg Tyr Pro Asn Glu Leu His Arg Ile Asp Ser Ala Leu Phe Val Leu 
                325                 330                 335     


Val Leu Asp Glu Ser Gln Glu Glu Thr Thr Asn Asp Gly Asp Asp Thr 
            340                 345                 350         


Ala Asp Ile Ser Gln Met Phe Asn Arg Thr Ile Thr Glu Arg Asp Lys 
        355                 360                 365             


Lys Cys Thr Ser Ala Asn Cys Lys Arg Val Phe Tyr Gly Thr Ser Ile 
    370                 375                 380                 


Ile Asn Ser Lys Gly His Gln Val Gly Ser Cys Val Ser Arg Trp Tyr 
385                 390                 395                 400 


Asp Lys Leu Gln Leu Val Val Thr Ala Asp Ala Lys Ala Thr Val Ile 
                405                 410                 415     


Trp Asp Ser Phe Thr Cys Asp Gly Ser Val Val Leu Arg Phe Thr Ser 
            420                 425                 430         


Glu Ile Tyr Thr Glu Ser Val Leu Arg Leu Ala Arg Asp Val Asn Ala 
        435                 440                 445             


Gly Asp Pro Gln Phe Ser Leu Trp Pro Asn Val Thr Gln Met Asp Pro 
    450                 455                 460                 


Glu Thr Lys Lys Leu Met Thr Ala Thr Ile Ser Ala Asp Gly Gly Gly 
465                 470                 475                 480 


Pro Ser Glu Ile Asp Pro Lys Leu Val Val Asn Lys Ile Asp Trp Ser 
                485                 490                 495     


Phe Ser Asn Ile Leu Asn Thr His Val His Leu Ser Glu Thr Lys Leu 
            500                 505                 510         


Ala Asp Leu Ile Ser Lys Tyr Asp Ile Val Arg Ala Ser Ile Pro Leu 
        515                 520                 525             


Gly Arg Arg Ser Ala Gln Arg Leu Gly Val Lys Pro Asp Ser Met Val 
    530                 535                 540                 


Gln Val Ala Leu Gln Ile Ala His Tyr Ala Leu Tyr Gly Arg Met Val 
545                 550                 555                 560 


Phe Gly Leu Glu Pro Val Ser Thr Arg Gly Phe Lys Asn Ser Arg Ser 
                565                 570                 575     


Ser Phe Ile Asn Ile Gln Ser Gln Ala Leu Leu Glu Leu Cys Gln Leu 
            580                 585                 590         


Phe Ile Ser Ser Ser Ile Asp Gly Thr Asp Lys Leu Asp Lys Phe Ile 
        595                 600                 605             


Gln Thr Cys Glu Thr His Asn Asn Met Val Lys His Ala Lys Ser Gly 
    610                 615                 620                 


Val Gly Tyr Glu Lys His Phe Asn Ala Leu Lys Tyr Leu Phe Lys Phe 
625                 630                 635                 640 


His Asp His Phe Gly Ile His Leu Ser Gly Asp Glu Ser Ser Ala Ala 
                645                 650                 655     


Lys Asp Leu Phe Glu Asn Pro Leu Val Leu Pro Phe Ser Gln Pro Glu 
            660                 665                 670         


Leu Ile Val Ala Asn Cys Gly Asn Ala Ala Thr Thr Thr Phe Gly Ile 
        675                 680                 685             


Thr Pro Ala Val Pro His Gly Phe Gly Ile Gly Tyr Ile Ile Lys Asp 
    690                 695                 700                 


Asp Gln Val Asp Leu Thr Val Thr Ser Gln Phe Arg Gln Gly Asp Arg 
705                 710                 715                 720 


Leu Met Phe Met Leu Ser Trp Val Leu Gly Glu Ile Arg Ser Tyr Trp 
                725                 730                 735     


Arg Met Ser Arg Gly Thr Ser His Asn Lys Thr Gly Val Lys Ile Ser 
            740                 745                 750         


Pro Val Val Asp Lys Leu Tyr Glu Met Asp Asn Ala Val Asn Asn Pro 
        755                 760                 765             


Pro Lys Arg Asn Gly His Thr Val Asn Gly Ser Arg Lys Thr Ser Ser 
    770                 775                 780                 


Ser Ser Gln Val Asn Leu Asn Arg Tyr Gly Gly Phe Phe Asp Leu Glu 
785                 790                 795                 800 


Gly His Ile Asp Ser Arg Asn Ile Ser Lys Thr Pro Ser Met Lys Asn 
                805                 810                 815     


Leu Gln Lys Thr Phe Asn Gly Leu Thr Met Ser Ala Asp Asn Asp His 
            820                 825                 830         


Ser Ser Ser Ala Val Ser Val Pro Thr Glu Lys Glu Lys Leu Asn Thr 
        835                 840                 845             


Gly His Glu Ile Leu Gln Ile Gln Pro Arg Glu Val Ala Ser Asn Gly 
    850                 855                 860                 


Leu Glu Ala Asp Asp Glu Thr Asp Ile Glu Ile Val Ala Gly Asn Ala 
865                 870                 875                 880 


Asp Gly Thr Ser Ser Ser Ala Ser Ser Ala Thr Ser Leu Asn Ser Lys 
                885                 890                 895     


Lys Arg Asn Val Ile Asn Ser Arg Phe Asp Ile Asp Phe Asp Arg Ser 
            900                 905                 910         


Arg Val Gly Arg Lys Val Ala Thr Leu Asp Gln 
        915                 920             


<210>  31
<211>  327
<212>  PRT
<213>  Saccharomyces cerevisiae


<220>
<221>  MISC_FEATURE
<223>  S. cerevisiae CRC1 (Accession No. NP_014743)

<400>  31

Met Ser Ser Asp Thr Ser Leu Ser Glu Ser Ser Leu Leu Lys Glu Glu 
1               5                   10                  15      


Ser Gly Ser Leu Thr Lys Ser Arg Pro Pro Ile Lys Ser Asn Pro Val 
            20                  25                  30          


Arg Glu Asn Ile Lys Ser Phe Val Ala Gly Gly Val Gly Gly Val Cys 
        35                  40                  45              


Ala Val Phe Thr Gly His Pro Phe Asp Leu Ile Lys Val Arg Cys Gln 
    50                  55                  60                  


Asn Gly Gln Ala Asn Ser Thr Val His Ala Ile Thr Asn Ile Ile Lys 
65                  70                  75                  80  


Glu Ala Lys Thr Gln Val Lys Gly Thr Leu Phe Thr Asn Ser Val Lys 
                85                  90                  95      


Gly Phe Tyr Lys Gly Val Ile Pro Pro Leu Leu Gly Val Thr Pro Ile 
            100                 105                 110         


Phe Ala Val Ser Phe Trp Gly Tyr Asp Val Gly Lys Lys Leu Val Thr 
        115                 120                 125             


Phe Asn Asn Lys Gln Gly Gly Ser Asn Glu Leu Thr Met Gly Gln Met 
    130                 135                 140                 


Ala Ala Ala Gly Phe Ile Ser Ala Ile Pro Thr Thr Leu Val Thr Ala 
145                 150                 155                 160 


Pro Thr Glu Arg Val Lys Val Val Leu Gln Thr Ser Ser Lys Gly Ser 
                165                 170                 175     


Phe Ile Gln Ala Ala Lys Thr Ile Val Lys Glu Gly Gly Ile Ala Ser 
            180                 185                 190         


Leu Phe Lys Gly Ser Leu Ala Thr Leu Ala Arg Asp Gly Pro Gly Ser 
        195                 200                 205             


Ala Leu Tyr Phe Ala Ser Tyr Glu Ile Ser Lys Asn Tyr Leu Asn Ser 
    210                 215                 220                 


Arg Gln Pro Arg Gln Asp Ala Gly Lys Asp Glu Pro Val Asn Ile Leu 
225                 230                 235                 240 


Asn Val Cys Leu Ala Gly Gly Ile Ala Gly Met Ser Met Trp Leu Ala 
                245                 250                 255     


Val Phe Pro Ile Asp Thr Ile Lys Thr Lys Leu Gln Ala Ser Ser Thr 
            260                 265                 270         


Arg Gln Asn Met Leu Ser Ala Thr Lys Glu Ile Tyr Leu Gln Arg Gly 
        275                 280                 285             


Gly Ile Lys Gly Phe Phe Pro Gly Leu Gly Pro Ala Leu Leu Arg Ser 
    290                 295                 300                 


Phe Pro Ala Asn Ala Ala Thr Phe Leu Gly Val Glu Met Thr His Ser 
305                 310                 315                 320 


Leu Phe Lys Lys Tyr Gly Ile 
                325         


<210>  32
<211>  669
<212>  PRT
<213>  Saccharomyces cerevisiae


<220>
<221>  MISC_FEATURE
<223>  S. cerevisiae FPS1 (Accession No. NP_013057)

<400>  32

Met Ser Asn Pro Gln Lys Ala Leu Asn Asp Phe Leu Ser Ser Glu Ser 
1               5                   10                  15      


Val His Thr His Asp Ser Ser Arg Lys Gln Ser Asn Lys Gln Ser Ser 
            20                  25                  30          


Asp Glu Gly Arg Ser Ser Ser Gln Pro Ser His His His Ser Gly Gly 
        35                  40                  45              


Thr Asn Asn Asn Asn Asn Asn Asn Asn Asn Asn Asn Asn Ser Asn Asn 
    50                  55                  60                  


Asn Asn Asn Gly Asn Asp Gly Gly Asn Asp Asp Asp Tyr Asp Tyr Glu 
65                  70                  75                  80  


Met Gln Asp Tyr Arg Pro Ser Pro Gln Ser Ala Arg Pro Thr Pro Thr 
                85                  90                  95      


Tyr Val Pro Gln Tyr Ser Val Glu Ser Gly Thr Ala Phe Pro Ile Gln 
            100                 105                 110         


Glu Val Ile Pro Ser Ala Tyr Ile Asn Thr Gln Asp Ile Asn His Lys 
        115                 120                 125             


Asp Asn Gly Pro Pro Ser Ala Ser Ser Asn Arg Ala Phe Arg Pro Arg 
    130                 135                 140                 


Gly Gln Thr Thr Val Ser Ala Asn Val Leu Asn Ile Glu Asp Phe Tyr 
145                 150                 155                 160 


Lys Asn Ala Asp Asp Ala His Thr Ile Pro Glu Ser His Leu Ser Arg 
                165                 170                 175     


Arg Arg Ser Arg Ser Arg Ala Thr Ser Asn Ala Gly His Ser Ala Asn 
            180                 185                 190         


Thr Gly Ala Thr Asn Gly Arg Thr Thr Gly Ala Gln Thr Asn Met Glu 
        195                 200                 205             


Ser Asn Glu Ser Pro Arg Asn Val Pro Ile Met Val Lys Pro Lys Thr 
    210                 215                 220                 


Leu Tyr Gln Asn Pro Gln Thr Pro Thr Val Leu Pro Ser Thr Tyr His 
225                 230                 235                 240 


Pro Ile Asn Lys Trp Ser Ser Val Lys Asn Thr Tyr Leu Lys Glu Phe 
                245                 250                 255     


Leu Ala Glu Phe Met Gly Thr Met Val Met Ile Ile Phe Gly Ser Ala 
            260                 265                 270         


Val Val Cys Gln Val Asn Val Ala Gly Lys Ile Gln Gln Asp Asn Phe 
        275                 280                 285             


Asn Val Ala Leu Asp Asn Leu Asn Val Thr Gly Ser Ser Ala Glu Thr 
    290                 295                 300                 


Ile Asp Ala Met Lys Ser Leu Thr Ser Leu Val Ser Ser Val Ala Gly 
305                 310                 315                 320 


Gly Thr Phe Asp Asp Val Ala Leu Gly Trp Ala Ala Ala Val Val Met 
                325                 330                 335     


Gly Tyr Phe Cys Ala Gly Gly Ser Ala Ile Ser Gly Ala His Leu Asn 
            340                 345                 350         


Pro Ser Ile Thr Leu Ala Asn Leu Val Tyr Arg Gly Phe Pro Leu Lys 
        355                 360                 365             


Lys Val Pro Tyr Tyr Phe Ala Gly Gln Leu Ile Gly Ala Phe Thr Gly 
    370                 375                 380                 


Ala Leu Ile Leu Phe Ile Trp Tyr Lys Arg Val Leu Gln Glu Ala Tyr 
385                 390                 395                 400 


Ser Asp Trp Trp Met Asn Glu Ser Val Ala Gly Met Phe Cys Val Phe 
                405                 410                 415     


Pro Lys Pro Tyr Leu Ser Ser Gly Arg Gln Phe Phe Ser Glu Phe Leu 
            420                 425                 430         


Cys Gly Ala Met Leu Gln Ala Gly Thr Phe Ala Leu Thr Asp Pro Tyr 
        435                 440                 445             


Thr Cys Leu Ser Ser Asp Val Phe Pro Leu Met Met Phe Ile Leu Ile 
    450                 455                 460                 


Phe Ile Ile Asn Ala Ser Met Ala Tyr Gln Thr Gly Thr Ala Met Asn 
465                 470                 475                 480 


Leu Ala Arg Asp Leu Gly Pro Arg Leu Ala Leu Tyr Ala Val Gly Phe 
                485                 490                 495     


Asp His Lys Met Leu Trp Val His His His His Phe Phe Trp Val Pro 
            500                 505                 510         


Met Val Gly Pro Phe Ile Gly Ala Leu Met Gly Gly Leu Val Tyr Asp 
        515                 520                 525             


Val Cys Ile Tyr Gln Gly His Glu Ser Pro Val Asn Trp Ser Leu Pro 
    530                 535                 540                 


Val Tyr Lys Glu Met Ile Met Arg Ala Trp Phe Arg Arg Pro Gly Trp 
545                 550                 555                 560 


Lys Lys Arg Asn Arg Ala Arg Arg Thr Ser Asp Leu Ser Asp Phe Ser 
                565                 570                 575     


Tyr Asn Asn Asp Asp Asp Glu Glu Phe Gly Glu Arg Met Ala Leu Gln 
            580                 585                 590         


Lys Thr Lys Thr Lys Ser Ser Ile Ser Asp Asn Glu Asn Glu Ala Gly 
        595                 600                 605             


Glu Lys Lys Val Gln Phe Lys Ser Val Gln Arg Gly Lys Arg Thr Phe 
    610                 615                 620                 


Gly Gly Ile Pro Thr Ile Leu Glu Glu Glu Asp Ser Ile Glu Thr Ala 
625                 630                 635                 640 


Ser Leu Gly Ala Thr Thr Thr Asp Ser Ile Gly Leu Ser Asp Thr Ser 
                645                 650                 655     


Ser Glu Asp Ser His Tyr Gly Asn Ala Lys Lys Val Thr 
            660                 665                 


<210>  33
<211>  391
<212>  PRT
<213>  Saccharomyces cerevisiae

<400>  33

Met Ser Ala Ala Ala Asp Arg Leu Asn Leu Thr Ser Gly His Leu Asn 
1               5                   10                  15      


Ala Gly Arg Lys Arg Ser Ser Ser Ser Val Ser Leu Lys Ala Ala Glu 
            20                  25                  30          


Lys Pro Phe Lys Val Thr Val Ile Gly Ser Gly Asn Trp Gly Thr Thr 
        35                  40                  45              


Ile Ala Lys Val Val Ala Glu Asn Cys Lys Gly Tyr Pro Glu Val Phe 
    50                  55                  60                  


Ala Pro Ile Val Gln Met Trp Val Phe Glu Glu Glu Ile Asn Gly Glu 
65                  70                  75                  80  


Lys Leu Thr Glu Ile Ile Asn Thr Arg His Gln Asn Val Lys Tyr Leu 
                85                  90                  95      


Pro Gly Ile Thr Leu Pro Asp Asn Leu Val Ala Asn Pro Asp Leu Ile 
            100                 105                 110         


Asp Ser Val Lys Asp Val Asp Ile Ile Val Phe Asn Ile Pro His Gln 
        115                 120                 125             


Phe Leu Pro Arg Ile Cys Ser Gln Leu Lys Gly His Val Asp Ser His 
    130                 135                 140                 


Val Arg Ala Ile Ser Cys Leu Lys Gly Phe Glu Val Gly Ala Lys Gly 
145                 150                 155                 160 


Val Gln Leu Leu Ser Ser Tyr Ile Thr Glu Glu Leu Gly Ile Gln Cys 
                165                 170                 175     


Gly Ala Leu Ser Gly Ala Asn Ile Ala Thr Glu Val Ala Gln Glu His 
            180                 185                 190         


Trp Ser Glu Thr Thr Val Ala Tyr His Ile Pro Lys Asp Phe Arg Gly 
        195                 200                 205             


Glu Gly Lys Asp Val Asp His Lys Val Leu Lys Ala Leu Phe His Arg 
    210                 215                 220                 


Pro Tyr Phe His Val Ser Val Ile Glu Asp Val Ala Gly Ile Ser Ile 
225                 230                 235                 240 


Cys Gly Ala Leu Lys Asn Val Val Ala Leu Gly Cys Gly Phe Val Glu 
                245                 250                 255     


Gly Leu Gly Trp Gly Asn Asn Ala Ser Ala Ala Ile Gln Arg Val Gly 
            260                 265                 270         


Leu Gly Glu Ile Ile Arg Phe Gly Gln Met Phe Phe Pro Glu Ser Arg 
        275                 280                 285             


Glu Glu Thr Tyr Tyr Gln Glu Ser Ala Gly Val Ala Asp Leu Ile Thr 
    290                 295                 300                 


Thr Cys Ala Gly Gly Arg Asn Val Lys Val Ala Arg Leu Met Ala Thr 
305                 310                 315                 320 


Ser Gly Lys Asp Ala Trp Glu Cys Glu Lys Glu Leu Leu Asn Gly Gln 
                325                 330                 335     


Ser Ala Gln Gly Leu Ile Thr Cys Lys Glu Val His Glu Trp Leu Glu 
            340                 345                 350         


Thr Cys Gly Ser Val Glu Asp Phe Pro Leu Phe Glu Ala Val Tyr Gln 
        355                 360                 365             


Ile Val Tyr Asn Asn Tyr Pro Met Lys Asn Leu Pro Asp Met Ile Glu 
    370                 375                 380                 


Glu Leu Asp Leu His Glu Asp 
385                 390     


<210>  34
<211>  440
<212>  PRT
<213>  Saccharomyces cerevisiae

<400>  34

Met Leu Ala Val Arg Arg Leu Thr Arg Tyr Thr Phe Leu Lys Arg Thr 
1               5                   10                  15      


His Pro Val Leu Tyr Thr Arg Arg Ala Tyr Lys Ile Leu Pro Ser Arg 
            20                  25                  30          


Ser Thr Phe Leu Arg Arg Ser Leu Leu Gln Thr Gln Leu His Ser Lys 
        35                  40                  45              


Met Thr Ala His Thr Asn Ile Lys Gln His Lys His Cys His Glu Asp 
    50                  55                  60                  


His Pro Ile Arg Arg Ser Asp Ser Ala Val Ser Ile Val His Leu Lys 
65                  70                  75                  80  


Arg Ala Pro Phe Lys Val Thr Val Ile Gly Ser Gly Asn Trp Gly Thr 
                85                  90                  95      


Thr Ile Ala Lys Val Ile Ala Glu Asn Thr Glu Leu His Ser His Ile 
            100                 105                 110         


Phe Glu Pro Glu Val Arg Met Trp Val Phe Asp Glu Lys Ile Gly Asp 
        115                 120                 125             


Glu Asn Leu Thr Asp Ile Ile Asn Thr Arg His Gln Asn Val Lys Tyr 
    130                 135                 140                 


Leu Pro Asn Ile Asp Leu Pro His Asn Leu Val Ala Asp Pro Asp Leu 
145                 150                 155                 160 


Leu His Ser Ile Lys Gly Ala Asp Ile Leu Val Phe Asn Ile Pro His 
                165                 170                 175     


Gln Phe Leu Pro Asn Ile Val Lys Gln Leu Gln Gly His Val Ala Pro 
            180                 185                 190         


His Val Arg Ala Ile Ser Cys Leu Lys Gly Phe Glu Leu Gly Ser Lys 
        195                 200                 205             


Gly Val Gln Leu Leu Ser Ser Tyr Val Thr Asp Glu Leu Gly Ile Gln 
    210                 215                 220                 


Cys Gly Ala Leu Ser Gly Ala Asn Leu Ala Pro Glu Val Ala Lys Glu 
225                 230                 235                 240 


His Trp Ser Glu Thr Thr Val Ala Tyr Gln Leu Pro Lys Asp Tyr Gln 
                245                 250                 255     


Gly Asp Gly Lys Asp Val Asp His Lys Ile Leu Lys Leu Leu Phe His 
            260                 265                 270         


Arg Pro Tyr Phe His Val Asn Val Ile Asp Asp Val Ala Gly Ile Ser 
        275                 280                 285             


Ile Ala Gly Ala Leu Lys Asn Val Val Ala Leu Ala Cys Gly Phe Val 
    290                 295                 300                 


Glu Gly Met Gly Trp Gly Asn Asn Ala Ser Ala Ala Ile Gln Arg Leu 
305                 310                 315                 320 


Gly Leu Gly Glu Ile Ile Lys Phe Gly Arg Met Phe Phe Pro Glu Ser 
                325                 330                 335     


Lys Val Glu Thr Tyr Tyr Gln Glu Ser Ala Gly Val Ala Asp Leu Ile 
            340                 345                 350         


Thr Thr Cys Ser Gly Gly Arg Asn Val Lys Val Ala Thr Tyr Met Ala 
        355                 360                 365             


Lys Thr Gly Lys Ser Ala Leu Glu Ala Glu Lys Glu Leu Leu Asn Gly 
    370                 375                 380                 


Gln Ser Ala Gln Gly Ile Ile Thr Cys Arg Glu Val His Glu Trp Leu 
385                 390                 395                 400 


Gln Thr Cys Glu Leu Thr Gln Glu Phe Pro Leu Phe Glu Ala Val Tyr 
                405                 410                 415     


Gln Ile Val Tyr Asn Asn Val Arg Met Glu Asp Leu Pro Glu Met Ile 
            420                 425                 430         


Glu Glu Leu Asp Ile Asp Asp Glu 
        435                 440 


<210>  35
<211>  250
<212>  PRT
<213>  Saccharomyces cerevisiae

<400>  35

Met Gly Leu Thr Thr Lys Pro Leu Ser Leu Lys Val Asn Ala Ala Leu 
1               5                   10                  15      


Phe Asp Val Asp Gly Thr Ile Ile Ile Ser Gln Pro Ala Ile Ala Ala 
            20                  25                  30          


Phe Trp Arg Asp Phe Gly Lys Asp Lys Pro Tyr Phe Asp Ala Glu His 
        35                  40                  45              


Val Ile Gln Val Ser His Gly Trp Arg Thr Phe Asp Ala Ile Ala Lys 
    50                  55                  60                  


Phe Ala Pro Asp Phe Ala Asn Glu Glu Tyr Val Asn Lys Leu Glu Ala 
65                  70                  75                  80  


Glu Ile Pro Val Lys Tyr Gly Glu Lys Ser Ile Glu Val Pro Gly Ala 
                85                  90                  95      


Val Lys Leu Cys Asn Ala Leu Asn Ala Leu Pro Lys Glu Lys Trp Ala 
            100                 105                 110         


Val Ala Thr Ser Gly Thr Arg Asp Met Ala Gln Lys Trp Phe Glu His 
        115                 120                 125             


Leu Gly Ile Arg Arg Pro Lys Tyr Phe Ile Thr Ala Asn Asp Val Lys 
    130                 135                 140                 


Gln Gly Lys Pro His Pro Glu Pro Tyr Leu Lys Gly Arg Asn Gly Leu 
145                 150                 155                 160 


Gly Tyr Pro Ile Asn Glu Gln Asp Pro Ser Lys Ser Lys Val Val Val 
                165                 170                 175     


Phe Glu Asp Ala Pro Ala Gly Ile Ala Ala Gly Lys Ala Ala Gly Cys 
            180                 185                 190         


Lys Ile Ile Gly Ile Ala Thr Thr Phe Asp Leu Asp Phe Leu Lys Glu 
        195                 200                 205             


Lys Gly Cys Asp Ile Ile Val Lys Asn His Glu Ser Ile Arg Val Gly 
    210                 215                 220                 


Gly Tyr Asn Ala Glu Thr Asp Glu Val Glu Phe Ile Phe Asp Asp Tyr 
225                 230                 235                 240 


Leu Tyr Ala Lys Asp Asp Leu Leu Lys Trp 
                245                 250 


<210>  36
<211>  250
<212>  PRT
<213>  Saccharomyces cerevisiae

<400>  36

Met Pro Leu Thr Thr Lys Pro Leu Ser Leu Lys Ile Asn Ala Ala Leu 
1               5                   10                  15      


Phe Asp Val Asp Gly Thr Ile Ile Ile Ser Gln Pro Ala Ile Ala Ala 
            20                  25                  30          


Phe Trp Arg Asp Phe Gly Lys Asp Lys Pro Tyr Phe Asp Ala Glu His 
        35                  40                  45              


Val Ile His Ile Ser His Gly Trp Arg Thr Tyr Asp Ala Ile Ala Lys 
    50                  55                  60                  


Phe Ala Pro Asp Phe Ala Asp Glu Glu Tyr Val Asn Lys Leu Glu Gly 
65                  70                  75                  80  


Glu Ile Pro Glu Lys Tyr Gly Glu His Ser Ile Glu Val Pro Gly Ala 
                85                  90                  95      


Val Lys Leu Cys Asn Ala Leu Asn Ala Leu Pro Lys Glu Lys Trp Ala 
            100                 105                 110         


Val Ala Thr Ser Gly Thr Arg Asp Met Ala Lys Lys Trp Phe Asp Ile 
        115                 120                 125             


Leu Lys Ile Lys Arg Pro Glu Tyr Phe Ile Thr Ala Asn Asp Val Lys 
    130                 135                 140                 


Gln Gly Lys Pro His Pro Glu Pro Tyr Leu Lys Gly Arg Asn Gly Leu 
145                 150                 155                 160 


Gly Phe Pro Ile Asn Glu Gln Asp Pro Ser Lys Ser Lys Val Val Val 
                165                 170                 175     


Phe Glu Asp Ala Pro Ala Gly Ile Ala Ala Gly Lys Ala Ala Gly Cys 
            180                 185                 190         


Lys Ile Val Gly Ile Ala Thr Thr Phe Asp Leu Asp Phe Leu Lys Glu 
        195                 200                 205             


Lys Gly Cys Asp Ile Ile Val Lys Asn His Glu Ser Ile Arg Val Gly 
    210                 215                 220                 


Glu Tyr Asn Ala Glu Thr Asp Glu Val Glu Leu Ile Phe Asp Asp Tyr 
225                 230                 235                 240 


Leu Tyr Ala Lys Asp Asp Leu Leu Lys Trp 
                245                 250 


<210>  37
<211>  316
<212>  PRT
<213>  Escherichia coli

<400>  37

Met Ser Lys Arg Lys Val Ala Ile Ile Gly Ser Gly Asn Ile Gly Thr 
1               5                   10                  15      


Asp Leu Met Ile Lys Ile Leu Arg His Gly Gln His Leu Glu Met Ala 
            20                  25                  30          


Val Met Val Gly Ile Asp Pro Gln Ser Asp Gly Leu Ala Arg Ala Arg 
        35                  40                  45              


Arg Met Gly Val Ala Thr Thr His Glu Gly Val Ile Gly Leu Met Asn 
    50                  55                  60                  


Met Pro Glu Phe Ala Asp Ile Asp Ile Val Phe Asp Ala Thr Ser Ala 
65                  70                  75                  80  


Gly Ala His Val Lys Asn Asp Ala Ala Leu Arg Glu Ala Lys Pro Asp 
                85                  90                  95      


Ile Arg Leu Ile Asp Leu Thr Pro Ala Ala Ile Gly Pro Tyr Cys Val 
            100                 105                 110         


Pro Val Val Asn Leu Glu Ala Asn Val Asp Gln Leu Asn Val Asn Met 
        115                 120                 125             


Val Thr Cys Gly Gly Gln Ala Thr Ile Pro Met Val Ala Ala Val Ser 
    130                 135                 140                 


Arg Val Ala Arg Val His Tyr Ala Glu Ile Ile Ala Ser Ile Ala Ser 
145                 150                 155                 160 


Lys Ser Ala Gly Pro Gly Thr Arg Ala Asn Ile Asp Glu Phe Thr Glu 
                165                 170                 175     


Thr Thr Ser Arg Ala Ile Glu Val Val Gly Gly Ala Ala Lys Gly Lys 
            180                 185                 190         


Ala Ile Ile Val Leu Asn Pro Ala Glu Pro Pro Leu Met Met Arg Asp 
        195                 200                 205             


Thr Val Tyr Val Leu Ser Asp Glu Ala Ser Gln Asp Asp Ile Glu Ala 
    210                 215                 220                 


Ser Ile Asn Glu Met Ala Glu Ala Val Gln Ala Tyr Val Pro Gly Tyr 
225                 230                 235                 240 


Arg Leu Lys Gln Arg Val Gln Phe Glu Val Ile Pro Gln Asp Lys Pro 
                245                 250                 255     


Val Asn Leu Pro Gly Val Gly Gln Phe Ser Gly Leu Lys Thr Ala Val 
            260                 265                 270         


Trp Leu Glu Val Glu Gly Ala Ala His Tyr Leu Pro Ala Tyr Ala Gly 
        275                 280                 285             


Asn Leu Asp Ile Met Thr Ser Ser Ala Leu Ala Thr Ala Glu Lys Met 
    290                 295                 300                 


Ala Gln Ser Leu Ala Arg Lys Ala Gly Glu Ala Ala 
305                 310                 315     


<210>  38
<211>  968
<212>  DNA
<213>  Artificial

<220>
<223>  mhpF codon optimised

<400>  38
ctgcagtcta gatgtctaag agaaaggttg ctatcatcgg ttctggtaac atcggtactg     60

acttgatgat caagatccta agacacggtc aacacttgga aatggctgtt atggttggta    120

tcgacccaca atctgacggt ttggctagag ctagaagaat gggtgttgct accacccacg    180

aaggtgttat cggtttgatg aacatgccag aattcgctga catcgacatc gttttcgacg    240

ctacctctgc tggtgctcac gttaagaacg acgctgcttt gagagaagct aagccagaca    300

tcagattgat cgacttgacc ccagctgcta tcggtccata ctgtgttcca gttgttaact    360

tggaagctaa cgttgaccaa ttaaacgtta acatggttac ctgtggtggt caagctacca    420

tcccaatggt tgctgctgtt tcaagagttg ctagagttca ctacgctgaa atcatcgctt    480

ctatcgcttc taagtctgct ggtccaggta ccagagctaa catcgacgaa ttcaccgaaa    540

ccacctctag ggctatcgaa gttgttggtg gtgctgctaa gggtaaggct atcatcgttt    600

tgaacccagc tgaaccacca ttgatgatga gagacaccgt ttacgttttg tctgacgaag    660

catctcaaga cgacatcgaa gcttcaatca acgaaatggc tgaagctgtt caagcatacg    720

ttccaggtta cagattgaag caaagagttc aattcgaagt tatcccacaa gacaagccag    780

ttaacttgcc aggtgttggt caattctctg gtttgaagac cgctgtttgg ttggaagttg    840

aaggtgctgc tcactacttg ccagcttacg ctggtaactt ggacattatg acctcttctg    900

ctttggctac cgctgaaaag atggctcaat ctttggctag aaaggctggt gaagctgctt    960

aagcgcgc                                                             968


<210>  39
<211>  760
<212>  PRT
<213>  Escherichia coli

<400>  39

Met Ser Glu Leu Asn Glu Lys Leu Ala Thr Ala Trp Glu Gly Phe Thr 
1               5                   10                  15      


Lys Gly Asp Trp Gln Asn Glu Val Asn Val Arg Asp Phe Ile Gln Lys 
            20                  25                  30          


Asn Tyr Thr Pro Tyr Glu Gly Asp Glu Ser Phe Leu Ala Gly Ala Thr 
        35                  40                  45              


Glu Ala Thr Thr Thr Leu Trp Asp Lys Val Met Glu Gly Val Lys Leu 
    50                  55                  60                  


Glu Asn Arg Thr His Ala Pro Val Asp Phe Asp Thr Ala Val Ala Ser 
65                  70                  75                  80  


Thr Ile Thr Ser His Asp Ala Gly Tyr Ile Asn Lys Gln Leu Glu Lys 
                85                  90                  95      


Ile Val Gly Leu Gln Thr Glu Ala Pro Leu Lys Arg Ala Leu Ile Pro 
            100                 105                 110         


Phe Gly Gly Ile Lys Met Ile Glu Gly Ser Cys Lys Ala Tyr Asn Arg 
        115                 120                 125             


Glu Leu Asp Pro Met Ile Lys Lys Ile Phe Thr Glu Tyr Arg Lys Thr 
    130                 135                 140                 


His Asn Gln Gly Val Phe Asp Val Tyr Thr Pro Asp Ile Leu Arg Cys 
145                 150                 155                 160 


Arg Lys Ser Gly Val Leu Thr Gly Leu Pro Asp Ala Tyr Gly Arg Gly 
                165                 170                 175     


Arg Ile Ile Gly Asp Tyr Arg Arg Val Ala Leu Tyr Gly Ile Asp Tyr 
            180                 185                 190         


Leu Met Lys Asp Lys Leu Ala Gln Phe Thr Ser Leu Gln Ala Asp Leu 
        195                 200                 205             


Glu Asn Gly Val Asn Leu Glu Gln Thr Ile Arg Leu Arg Glu Glu Ile 
    210                 215                 220                 


Ala Glu Gln His Arg Ala Leu Gly Gln Met Lys Glu Met Ala Ala Lys 
225                 230                 235                 240 


Tyr Gly Tyr Asp Ile Ser Gly Pro Ala Thr Asn Ala Gln Glu Ala Ile 
                245                 250                 255     


Gln Trp Thr Tyr Phe Gly Tyr Leu Ala Ala Val Lys Ser Gln Asn Gly 
            260                 265                 270         


Ala Ala Met Ser Phe Gly Arg Thr Ser Thr Phe Leu Asp Val Tyr Ile 
        275                 280                 285             


Glu Arg Asp Leu Lys Ala Gly Lys Ile Thr Glu Gln Glu Ala Gln Glu 
    290                 295                 300                 


Met Val Asp His Leu Val Met Lys Leu Arg Met Val Arg Phe Leu Arg 
305                 310                 315                 320 


Thr Pro Glu Tyr Asp Glu Leu Phe Ser Gly Asp Pro Ile Trp Ala Thr 
                325                 330                 335     


Glu Ser Ile Gly Gly Met Gly Leu Asp Gly Arg Thr Leu Val Thr Lys 
            340                 345                 350         


Asn Ser Phe Arg Phe Leu Asn Thr Leu Tyr Thr Met Gly Pro Ser Pro 
        355                 360                 365             


Glu Pro Asn Met Thr Ile Leu Trp Ser Glu Lys Leu Pro Leu Asn Phe 
    370                 375                 380                 


Lys Lys Phe Ala Ala Lys Val Ser Ile Asp Thr Ser Ser Leu Gln Tyr 
385                 390                 395                 400 


Glu Asn Asp Asp Leu Met Arg Pro Asp Phe Asn Asn Asp Asp Tyr Ala 
                405                 410                 415     


Ile Ala Cys Cys Val Ser Pro Met Ile Val Gly Lys Gln Met Gln Phe 
            420                 425                 430         


Phe Gly Ala Arg Ala Asn Leu Ala Lys Thr Met Leu Tyr Ala Ile Asn 
        435                 440                 445             


Gly Gly Val Asp Glu Lys Leu Lys Met Gln Val Gly Pro Lys Ser Glu 
    450                 455                 460                 


Pro Ile Lys Gly Asp Val Leu Asn Tyr Asp Glu Val Met Glu Arg Met 
465                 470                 475                 480 


Asp His Phe Met Asp Trp Leu Ala Lys Gln Tyr Ile Thr Ala Leu Asn 
                485                 490                 495     


Ile Ile His Tyr Met His Asp Lys Tyr Ser Tyr Glu Ala Ser Leu Met 
            500                 505                 510         


Ala Leu His Asp Arg Asp Val Ile Arg Thr Met Ala Cys Gly Ile Ala 
        515                 520                 525             


Gly Leu Ser Val Ala Ala Asp Ser Leu Ser Ala Ile Lys Tyr Ala Lys 
    530                 535                 540                 


Val Lys Pro Ile Arg Asp Glu Asp Gly Leu Ala Ile Asp Phe Glu Ile 
545                 550                 555                 560 


Glu Gly Glu Tyr Pro Gln Phe Gly Asn Asn Asp Pro Arg Val Asp Asp 
                565                 570                 575     


Leu Ala Val Asp Leu Val Glu Arg Phe Met Lys Lys Ile Gln Lys Leu 
            580                 585                 590         


His Thr Tyr Arg Asp Ala Ile Pro Thr Gln Ser Val Leu Thr Ile Thr 
        595                 600                 605             


Ser Asn Val Val Tyr Gly Lys Lys Thr Gly Asn Thr Pro Asp Gly Arg 
    610                 615                 620                 


Arg Ala Gly Ala Pro Phe Gly Pro Gly Ala Asn Pro Met His Gly Arg 
625                 630                 635                 640 


Asp Gln Lys Gly Ala Val Ala Ser Leu Thr Ser Val Ala Lys Leu Pro 
                645                 650                 655     


Phe Ala Tyr Ala Lys Asp Gly Ile Ser Tyr Thr Phe Ser Ile Val Pro 
            660                 665                 670         


Asn Ala Leu Gly Lys Asp Asp Glu Val Arg Lys Thr Asn Leu Ala Gly 
        675                 680                 685             


Leu Met Asp Gly Tyr Phe His His Glu Ala Ser Ile Glu Gly Gly Gln 
    690                 695                 700                 


His Leu Asn Val Asn Val Met Asn Arg Glu Met Leu Leu Asp Ala Met 
705                 710                 715                 720 


Glu Asn Pro Glu Lys Tyr Pro Gln Leu Thr Ile Arg Val Ser Gly Tyr 
                725                 730                 735     


Ala Val Arg Phe Asn Ser Leu Thr Lys Glu Gln Gln Gln Asp Val Ile 
            740                 745                 750         


Thr Arg Thr Phe Thr Gln Ser Met 
        755                 760 


<210>  40
<211>  2283
<212>  DNA
<213>  Artificial

<220>
<223>  synthetic codon optimised E.coli pflB

<400>  40
atgtctgaat tgaacgagaa gttggctacc gcttgggaag gtttcaccaa gggtgactgg     60

caaaacgaag ttaacgttag agacttcatc caaaagaact acaccccata cgaaggtgac    120

gaatctttct tggctggtgc taccgaagct accaccacct tgtgggacaa ggttatggaa    180

ggtgttaagt tggaaaacag aacccacgct ccagttgact tcgacaccgc tgttgcttct    240

accatcacct ctcacgacgc tggttacatc aacaagcaat tggaaaagat cgttggttta    300

caaaccgaag ctccattgaa gagagctttg atcccattcg gtggtatcaa gatgatcgaa    360

ggttcttgta aggcttacaa cagagaattg gacccaatga tcaagaagat tttcaccgaa    420

tacagaaaga cccacaacca aggtgttttc gacgtttaca ctccagacat cttgagatgt    480

agaaagtctg gtgttttgac tggtttgcca gacgcttacg gtagaggtag aatcatcggt    540

gactacagaa gagttgcttt gtacggtatc gactacttga tgaaggacaa gttggctcaa    600

ttcacctctt tgcaagctga cttggaaaac ggtgttaact tggaacaaac catcagattg    660

agagaagaaa tcgctgaaca acacagagct ttgggtcaaa tgaaggaaat ggctgctaag    720

tacggttacg acatctctgg tccagctacc aacgctcaag aagctatcca atggacctac    780

ttcggttact tggctgctgt taagtctcaa aacggtgctg ctatgtcttt cggtaggacc    840

tctaccttct tggacgttta catcgaaaga gacttgaagg ctggtaagat caccgaacaa    900

gaagctcaag aaatggttga ccacttggtt atgaagttga gaatggttag attcttgaga    960

accccagaat acgacgaatt gttctctggt gacccaatct gggctaccga atctatcggt   1020

ggtatgggtt tggacggtag aaccttggtt accaagaact ctttcagatt cttgaacacc   1080

ttatacacca tgggtccatc tccagaacca aacatgacca tcttgtggtc tgaaaagtta   1140

ccattgaact tcaagaagtt cgctgctaag gtttctatcg acacctcttc tttgcaatac   1200

gaaaacgacg acttgatgag accagacttc aacaacgacg actacgctat cgcttgttgt   1260

gtttctccaa tgatcgttgg taagcaaatg caattcttcg gtgctagagc taacttggct   1320

aagaccatgt tgtacgctat caacggtggt gttgacgaaa agttgaagat gcaagttggt   1380

ccaaagtctg aaccaatcaa gggtgacgtt ttgaactacg acgaagttat ggaaagaatg   1440

gaccacttca tggactggtt ggctaagcaa tacatcaccg ctttgaacat catccactac   1500

atgcacgaca agtactctta cgaagcatca ttgatggctt tgcacgacag agacgtaatc   1560

agaaccatgg cttgtggtat cgctggtttg tctgttgctg ctgactcttt gtctgctatc   1620

aagtacgcta aggttaagcc aatcagagac gaagacggtt tggctatcga cttcgaaatc   1680

gaaggtgaat accctcaatt cggtaacaac gacccaagag ttgacgactt ggctgttgac   1740

ttggttgaaa gatttatgaa gaagatccaa aagttgcaca cctacagaga cgctatccca   1800

acccaatctg ttttgactat cacatctaac gttgtttacg gtaagaagac tggtaacacc   1860

ccagacggta gaagagctgg tgctccattc ggtccaggtg ctaacccaat gcacggtaga   1920

gaccaaaagg gtgctgtagc atctttgacc tctgttgcta agttgccatt cgcttacgct   1980

aaggacggta tctcttacac cttctctatc gttccaaacg ctttgggtaa ggacgatgaa   2040

gttagaaaga ccaacttggc tggtttgatg gacggttact tccaccacga agcatctatc   2100

gaaggtggtc aacacttgaa cgtaaatgtt atgaacagag aaatgttgtt ggacgctatg   2160

gaaaacccag aaaagtaccc acaattgacc atcagagttt ctggttacgc tgttagattc   2220

aactctttga ccaaggaaca acaacaagac gttatcacca gaaccttcac ccaatctatg   2280

taa                                                                 2283


<210>  41
<211>  246
<212>  PRT
<213>  Escherichia coli

<400>  41

Met Ser Val Ile Gly Arg Ile His Ser Phe Glu Ser Cys Gly Thr Val 
1               5                   10                  15      


Asp Gly Pro Gly Ile Arg Phe Ile Thr Phe Phe Gln Gly Cys Leu Met 
            20                  25                  30          


Arg Cys Leu Tyr Cys His Asn Arg Asp Thr Trp Asp Thr His Gly Gly 
        35                  40                  45              


Lys Glu Val Thr Val Glu Asp Leu Met Lys Glu Val Val Thr Tyr Arg 
    50                  55                  60                  


His Phe Met Asn Ala Ser Gly Gly Gly Val Thr Ala Ser Gly Gly Glu 
65                  70                  75                  80  


Ala Ile Leu Gln Ala Glu Phe Val Arg Asp Trp Phe Arg Ala Cys Lys 
                85                  90                  95      


Lys Glu Gly Ile His Thr Cys Leu Asp Thr Asn Gly Phe Val Arg Arg 
            100                 105                 110         


Tyr Asp Pro Val Ile Asp Glu Leu Leu Glu Val Thr Asp Leu Val Met 
        115                 120                 125             


Leu Asp Leu Lys Gln Met Asn Asp Glu Ile His Gln Asn Leu Val Gly 
    130                 135                 140                 


Val Ser Asn His Arg Thr Leu Glu Phe Ala Lys Tyr Leu Ala Asn Lys 
145                 150                 155                 160 


Asn Val Lys Val Trp Ile Arg Tyr Val Val Val Pro Gly Trp Ser Asp 
                165                 170                 175     


Asp Asp Asp Ser Ala His Arg Leu Gly Glu Phe Thr Arg Asp Met Gly 
            180                 185                 190         


Asn Val Glu Lys Ile Glu Leu Leu Pro Tyr His Glu Leu Gly Lys His 
        195                 200                 205             


Lys Trp Val Ala Met Gly Glu Glu Tyr Lys Leu Asp Gly Val Lys Pro 
    210                 215                 220                 


Pro Lys Lys Glu Thr Met Glu Arg Val Lys Gly Ile Leu Glu Gln Tyr 
225                 230                 235                 240 


Gly His Lys Val Met Phe 
                245     


<210>  42
<211>  741
<212>  DNA
<213>  Artificial

<220>
<223>  synthetic codon optimised E.coli pflA

<400>  42
atgtctgtta tcggtagaat ccactctttc gaatcttgtg gtactgttga cggtccaggt     60

atcagattca tcaccttctt ccaaggttgt ttgatgagat gtttgtactg tcacaacaga    120

gacacctggg acacccacgg tggtaaggaa gttactgttg aagacttgat gaaggaagtt    180

gttacctaca gacactttat gaacgcttca ggaggtggtg ttaccgcttc tggtggtgaa    240

gctatcttgc aagctgaatt tgttagagac tggttcagag cttgtaagaa ggaaggtatc    300

cacacctgtt tggacaccaa cggtttcgtt agaagatacg acccagttat cgacgaattg    360

ttggaagtta ccgacttggt tatgttggac ttgaagcaaa tgaacgacga aatccaccaa    420

aacttggttg gtgtttctaa ccacagaacc ttggaatttg ctaagtactt ggctaacaag    480

aacgttaagg tttggatcag atacgttgtt gttccaggtt ggtctgacga cgacgactct    540

gctcacagat tgggtgagtt caccagagac atgggtaacg ttgaaaagat cgaattgttg    600

ccataccacg aattgggtaa gcacaagtgg gttgctatgg gtgaagaata caagttggac    660

ggtgttaagc caccaaagaa ggaaaccatg gaaagagtta agggtatctt ggaacaatac    720

ggtcacaagg ttatgttcta a                                              741


<210>  43
<211>  376
<212>  PRT
<213>  Saccharomyces cerevisiae

<400>  43

Met Ser Lys Gly Lys Val Leu Leu Val Leu Tyr Glu Gly Gly Lys His 
1               5                   10                  15      


Ala Glu Glu Gln Glu Lys Leu Leu Gly Cys Ile Glu Asn Glu Leu Gly 
            20                  25                  30          


Ile Arg Asn Phe Ile Glu Glu Gln Gly Tyr Glu Leu Val Thr Thr Ile 
        35                  40                  45              


Asp Lys Asp Pro Glu Pro Thr Ser Thr Val Asp Arg Glu Leu Lys Asp 
    50                  55                  60                  


Ala Glu Ile Val Ile Thr Thr Pro Phe Phe Pro Ala Tyr Ile Ser Arg 
65                  70                  75                  80  


Asn Arg Ile Ala Glu Ala Pro Asn Leu Lys Leu Cys Val Thr Ala Gly 
                85                  90                  95      


Val Gly Ser Asp His Val Asp Leu Glu Ala Ala Asn Glu Arg Lys Ile 
            100                 105                 110         


Thr Val Thr Glu Val Thr Gly Ser Asn Val Val Ser Val Ala Glu His 
        115                 120                 125             


Val Met Ala Thr Ile Leu Val Leu Ile Arg Asn Tyr Asn Gly Gly His 
    130                 135                 140                 


Gln Gln Ala Ile Asn Gly Glu Trp Asp Ile Ala Gly Val Ala Lys Asn 
145                 150                 155                 160 


Glu Tyr Asp Leu Glu Asp Lys Ile Ile Ser Thr Val Gly Ala Gly Arg 
                165                 170                 175     


Ile Gly Tyr Arg Val Leu Glu Arg Leu Val Ala Phe Asn Pro Lys Lys 
            180                 185                 190         


Leu Leu Tyr Tyr Asp Tyr Gln Glu Leu Pro Ala Glu Ala Ile Asn Arg 
        195                 200                 205             


Leu Asn Glu Ala Ser Lys Leu Phe Asn Gly Arg Gly Asp Ile Val Gln 
    210                 215                 220                 


Arg Val Glu Lys Leu Glu Asp Met Val Ala Gln Ser Asp Val Val Thr 
225                 230                 235                 240 


Ile Asn Cys Pro Leu His Lys Asp Ser Arg Gly Leu Phe Asn Lys Lys 
                245                 250                 255     


Leu Ile Ser His Met Lys Asp Gly Ala Tyr Leu Val Asn Thr Ala Arg 
            260                 265                 270         


Gly Ala Ile Cys Val Ala Glu Asp Val Ala Glu Ala Val Lys Ser Gly 
        275                 280                 285             


Lys Leu Ala Gly Tyr Gly Gly Asp Val Trp Asp Lys Gln Pro Ala Pro 
    290                 295                 300                 


Lys Asp His Pro Trp Arg Thr Met Asp Asn Lys Asp His Val Gly Asn 
305                 310                 315                 320 


Ala Met Thr Val His Ile Ser Gly Thr Ser Leu Asp Ala Gln Lys Arg 
                325                 330                 335     


Tyr Ala Gln Gly Val Lys Asn Ile Leu Asn Ser Tyr Phe Ser Lys Lys 
            340                 345                 350         


Phe Asp Tyr Arg Pro Gln Asp Ile Ile Val Gln Asn Gly Ser Tyr Ala 
        355                 360                 365             


Thr Arg Ala Tyr Gly Gln Lys Lys 
    370                 375     


<210>  44
<211>  376
<212>  PRT
<213>  Saccharomyces cerevisiae

<400>  44

Met Ser Lys Gly Lys Val Leu Leu Val Leu Tyr Glu Gly Gly Lys His 
1               5                   10                  15      


Ala Glu Glu Gln Glu Lys Leu Leu Gly Cys Ile Glu Asn Glu Leu Gly 
            20                  25                  30          


Ile Arg Asn Phe Ile Glu Glu Gln Gly Tyr Glu Leu Val Thr Thr Ile 
        35                  40                  45              


Asp Lys Asp Pro Glu Pro Thr Ser Thr Val Asp Arg Glu Leu Lys Asp 
    50                  55                  60                  


Ala Glu Ile Val Ile Thr Thr Pro Phe Phe Pro Ala Tyr Ile Ser Arg 
65                  70                  75                  80  


Asn Arg Ile Ala Glu Ala Pro Asn Leu Lys Leu Cys Val Thr Ala Gly 
                85                  90                  95      


Val Gly Ser Asp His Val Asp Leu Glu Ala Ala Asn Glu Arg Lys Ile 
            100                 105                 110         


Thr Val Thr Glu Val Thr Gly Ser Asn Val Val Ser Val Ala Glu His 
        115                 120                 125             


Val Met Ala Thr Ile Leu Val Leu Ile Arg Asn Tyr Asn Gly Gly His 
    130                 135                 140                 


Gln Gln Ala Ile Asn Gly Glu Trp Asp Ile Ala Gly Val Ala Lys Asn 
145                 150                 155                 160 


Glu Tyr Asp Leu Glu Asp Lys Ile Ile Ser Thr Val Gly Ala Gly Arg 
                165                 170                 175     


Ile Gly Tyr Arg Val Leu Glu Arg Leu Val Ala Phe Asn Pro Lys Lys 
            180                 185                 190         


Leu Leu Tyr Tyr Asp Tyr Gln Glu Leu Pro Ala Glu Ala Ile Asn Arg 
        195                 200                 205             


Leu Asn Glu Ala Ser Lys Leu Phe Asn Gly Arg Gly Asp Ile Val Gln 
    210                 215                 220                 


Arg Val Glu Lys Leu Glu Asp Met Val Ala Gln Ser Asp Val Val Thr 
225                 230                 235                 240 


Ile Asn Cys Pro Leu His Lys Asp Ser Arg Gly Leu Phe Asn Lys Lys 
                245                 250                 255     


Leu Ile Ser His Met Lys Asp Gly Ala Tyr Leu Val Asn Thr Ala Arg 
            260                 265                 270         


Gly Ala Ile Cys Val Ala Glu Asp Val Ala Glu Ala Val Lys Ser Gly 
        275                 280                 285             


Lys Leu Ala Gly Tyr Gly Gly Asp Val Trp Asp Lys Gln Pro Ala Pro 
    290                 295                 300                 


Lys Asp His Pro Trp Arg Thr Met Asp Asn Lys Asp His Val Gly Asn 
305                 310                 315                 320 


Ala Met Thr Val His Ile Ser Gly Thr Ser Leu Asp Ala Gln Lys Arg 
                325                 330                 335     


Tyr Ala Gln Gly Val Lys Asn Ile Leu Asn Ser Tyr Phe Ser Lys Lys 
            340                 345                 350         


Phe Asp Tyr Arg Pro Gln Asp Ile Ile Val Gln Asn Gly Ser Tyr Ala 
        355                 360                 365             


Thr Arg Ala Tyr Gly Gln Lys Lys 
    370                 375     


<210>  45
<211>  652
<212>  PRT
<213>  Salmonella enterica


<220>
<221>  MISC_FEATURE
<223>  Salmonella enterica acetyl-CoA synthetase

<400>  45

Met Ser Gln Thr His Lys His Ala Ile Pro Ala Asn Ile Ala Asp Arg 
1               5                   10                  15      


Cys Leu Ile Asn Pro Glu Gln Tyr Glu Thr Lys Tyr Lys Gln Ser Ile 
            20                  25                  30          


Asn Asp Pro Asp Thr Phe Trp Gly Glu Gln Gly Lys Ile Leu Asp Trp 
        35                  40                  45              


Ile Thr Pro Tyr Gln Lys Val Lys Asn Thr Ser Phe Ala Pro Gly Asn 
    50                  55                  60                  


Val Ser Ile Lys Trp Tyr Glu Asp Gly Thr Leu Asn Leu Ala Ala Asn 
65                  70                  75                  80  


Cys Leu Asp Arg His Leu Gln Glu Asn Gly Asp Arg Thr Ala Ile Ile 
                85                  90                  95      


Trp Glu Gly Asp Asp Thr Ser Gln Ser Lys His Ile Ser Tyr Arg Glu 
            100                 105                 110         


Leu His Arg Asp Val Cys Arg Phe Ala Asn Thr Leu Leu Asp Leu Gly 
        115                 120                 125             


Ile Lys Lys Gly Asp Val Val Ala Ile Tyr Met Pro Met Val Pro Glu 
    130                 135                 140                 


Ala Ala Val Ala Met Leu Ala Cys Ala Arg Ile Gly Ala Val His Ser 
145                 150                 155                 160 


Val Ile Phe Gly Gly Phe Ser Pro Glu Ala Val Ala Gly Arg Ile Ile 
                165                 170                 175     


Asp Ser Ser Ser Arg Leu Val Ile Thr Ala Asp Glu Gly Val Arg Ala 
            180                 185                 190         


Gly Arg Ser Ile Pro Leu Lys Lys Asn Val Asp Asp Ala Leu Lys Asn 
        195                 200                 205             


Pro Asn Val Thr Ser Val Glu His Val Ile Val Leu Lys Arg Thr Gly 
    210                 215                 220                 


Ser Asp Ile Asp Trp Gln Glu Gly Arg Asp Leu Trp Trp Arg Asp Leu 
225                 230                 235                 240 


Ile Glu Lys Ala Ser Pro Glu His Gln Pro Glu Ala Met Asn Ala Glu 
                245                 250                 255     


Asp Pro Leu Phe Ile Leu Tyr Thr Ser Gly Ser Thr Gly Lys Pro Lys 
            260                 265                 270         


Gly Val Leu His Thr Thr Gly Gly Tyr Leu Val Tyr Ala Ala Thr Thr 
        275                 280                 285             


Phe Lys Tyr Val Phe Asp Tyr His Pro Gly Asp Ile Tyr Trp Cys Thr 
    290                 295                 300                 


Ala Asp Val Gly Trp Val Thr Gly His Ser Tyr Leu Leu Tyr Gly Pro 
305                 310                 315                 320 


Leu Ala Cys Gly Ala Thr Thr Leu Met Phe Glu Gly Val Pro Asn Trp 
                325                 330                 335     


Pro Thr Pro Ala Arg Met Cys Gln Val Val Asp Lys His Gln Val Asn 
            340                 345                 350         


Ile Leu Tyr Thr Ala Pro Thr Ala Ile Arg Ala Leu Met Ala Glu Gly 
        355                 360                 365             


Asp Lys Ala Ile Glu Gly Thr Asp Arg Ser Ser Leu Arg Ile Leu Gly 
    370                 375                 380                 


Ser Val Gly Glu Pro Ile Asn Pro Glu Ala Trp Glu Trp Tyr Trp Lys 
385                 390                 395                 400 


Lys Ile Gly Lys Glu Lys Cys Pro Val Val Asp Thr Trp Trp Gln Thr 
                405                 410                 415     


Glu Thr Gly Gly Phe Met Ile Thr Pro Leu Pro Gly Ala Ile Glu Leu 
            420                 425                 430         


Lys Ala Gly Ser Ala Thr Arg Pro Phe Phe Gly Val Gln Pro Ala Leu 
        435                 440                 445             


Val Asp Asn Glu Gly His Pro Gln Glu Gly Ala Thr Glu Gly Asn Leu 
    450                 455                 460                 


Val Ile Thr Asp Ser Trp Pro Gly Gln Ala Arg Thr Leu Phe Gly Asp 
465                 470                 475                 480 


His Glu Arg Phe Glu Gln Thr Tyr Phe Ser Thr Phe Lys Asn Met Tyr 
                485                 490                 495     


Phe Ser Gly Asp Gly Ala Arg Arg Asp Glu Asp Gly Tyr Tyr Trp Ile 
            500                 505                 510         


Thr Gly Arg Val Asp Asp Val Leu Asn Val Ser Gly His Arg Leu Gly 
        515                 520                 525             


Thr Ala Glu Ile Glu Ser Ala Leu Val Ala His Pro Lys Ile Ala Glu 
    530                 535                 540                 


Ala Ala Val Val Gly Ile Pro His Ala Ile Lys Gly Gln Ala Ile Tyr 
545                 550                 555                 560 


Ala Tyr Val Thr Leu Asn His Gly Glu Glu Pro Ser Pro Glu Leu Tyr 
                565                 570                 575     


Ala Glu Val Arg Asn Trp Val Arg Lys Glu Ile Gly Pro Leu Ala Thr 
            580                 585                 590         


Pro Asp Val Leu His Trp Thr Asp Ser Leu Pro Lys Thr Arg Ser Gly 
        595                 600                 605             


Lys Ile Met Arg Arg Ile Leu Arg Lys Ile Ala Ala Gly Asp Thr Ser 
    610                 615                 620                 


Asn Leu Gly Asp Thr Ser Thr Leu Ala Asp Pro Gly Val Val Glu Lys 
625                 630                 635                 640 


Pro Leu Glu Glu Lys Gln Ala Ile Ala Met Pro Ser 
                645                 650         


<210>  46
<211>  506
<212>  PRT
<213>  Pseudomonas aeruginosa

<400>  46

Met Ile Tyr Ala Ala Pro Gly Thr Pro Gly Ala Val Val Thr Phe Lys 
1               5                   10                  15      


Pro Arg Tyr Gly Asn Tyr Ile Gly Gly Glu Phe Val Pro Pro Val Lys 
            20                  25                  30          


Gly Gln Tyr Phe Thr Asn Thr Ser Pro Val Asn Gly Gln Pro Ile Ala 
        35                  40                  45              


Glu Phe Pro Arg Ser Thr Ala Glu Asp Ile Asp Lys Ala Leu Asp Ala 
    50                  55                  60                  


Ala His Ala Ala Ala Asp Ala Trp Gly Arg Thr Ser Val Gln Glu Arg 
65                  70                  75                  80  


Ser Asn Ile Leu Leu Lys Ile Ala Asp Arg Ile Glu Gln Asn Leu Glu 
                85                  90                  95      


Leu Leu Ala Val Thr Glu Thr Trp Asp Asn Gly Lys Ala Val Arg Glu 
            100                 105                 110         


Thr Leu Asn Ala Asp Ile Pro Leu Ala Ala Asp His Phe Arg Tyr Phe 
        115                 120                 125             


Ala Gly Cys Ile Arg Ala Gln Glu Gly Ser Ala Ala Glu Ile Asn Asp 
    130                 135                 140                 


Ser Thr Val Ala Tyr His Ile His Glu Pro Leu Gly Val Val Gly Gln 
145                 150                 155                 160 


Ile Ile Pro Trp Asn Phe Pro Leu Leu Met Ala Ala Trp Lys Leu Ala 
                165                 170                 175     


Pro Ala Leu Ala Ala Gly Asn Cys Val Val Leu Lys Pro Ala Glu Gln 
            180                 185                 190         


Thr Pro Leu Gly Ile Cys Val Leu Leu Glu Leu Ile Gly Asp Leu Leu 
        195                 200                 205             


Pro Pro Gly Val Leu Asn Val Val Gln Gly Phe Gly Arg Glu Ala Gly 
    210                 215                 220                 


Glu Ala Leu Ala Thr Ser Lys Arg Ile Ala Lys Ile Ala Phe Thr Gly 
225                 230                 235                 240 


Ser Thr Pro Val Gly Ser His Ile Leu Lys Cys Ala Ala Glu Asn Ile 
                245                 250                 255     


Ile Pro Ser Thr Val Glu Leu Gly Gly Lys Ser Pro Asn Ile Tyr Phe 
            260                 265                 270         


Glu Asp Ile Met Gln Ala Glu Pro Ala Phe Ile Glu Lys Ala Ala Glu 
        275                 280                 285             


Gly Leu Val Leu Ala Phe Phe Asn Gln Gly Glu Val Cys Thr Cys Pro 
    290                 295                 300                 


Ser Arg Ala Leu Val Gln Glu Ser Ile Tyr Pro Ala Phe Met Glu Glu 
305                 310                 315                 320 


Val Leu Lys Lys Val Arg Ala Ile Lys Arg Gly Asp Pro Leu Asp Thr 
                325                 330                 335     


Glu Thr Met Val Gly Ala Gln Ala Ser Gln Gln Gln Tyr Glu Lys Ile 
            340                 345                 350         


Leu Ser Tyr Leu Asp Ile Ala Gln Gln Glu Gly Ala Glu Val Leu Thr 
        355                 360                 365             


Gly Gly Ser Val Glu Lys Leu Glu Gly Asn Leu Ala Ser Gly Tyr Tyr 
    370                 375                 380                 


Ile Gln Pro Thr Leu Leu Lys Gly His Asn Lys Met Arg Val Phe Gln 
385                 390                 395                 400 


Glu Glu Ile Phe Gly Pro Val Val Gly Val Thr Thr Phe Lys Asp Glu 
                405                 410                 415     


Ala Glu Ala Leu Ala Ile Ala Asn Asp Thr Glu Tyr Gly Leu Gly Ala 
            420                 425                 430         


Gly Leu Trp Thr Arg Asp Ile Asn Arg Ala Tyr Arg Met Gly Arg Gly 
        435                 440                 445             


Ile Lys Ala Gly Arg Val Trp Thr Asn Cys Tyr His Leu Tyr Pro Ala 
    450                 455                 460                 


His Ala Ala Phe Gly Gly Tyr Lys Lys Ser Gly Val Gly Arg Glu Thr 
465                 470                 475                 480 


His Lys Met Met Leu Asp His Tyr Gln Gln Thr Lys Asn Leu Leu Val 
                485                 490                 495     


Ser Tyr Asp Ile Asp Pro Leu Gly Phe Phe 
            500                 505     


<210>  47
<211>  401
<212>  PRT
<213>  Saccharomyces cerevisiae


<220>
<221>  MISC_FEATURE
<223>  POT1 S.cerevisiae

<400>  47

Met Gly Lys Gly Glu Ser Lys Arg Lys Asn Ser Leu Leu Glu Lys Arg 
1               5                   10                  15      


Pro Glu Asp Val Val Ile Val Ala Ala Asn Arg Ser Ala Ile Gly Lys 
            20                  25                  30          


Gly Phe Lys Gly Ala Phe Lys Asp Val Asn Thr Asp Tyr Leu Leu Tyr 
        35                  40                  45              


Asn Phe Leu Asn Glu Phe Ile Gly Arg Phe Pro Glu Pro Leu Arg Ala 
    50                  55                  60                  


Asp Leu Asn Leu Ile Glu Glu Val Ala Cys Gly Asn Val Leu Asn Val 
65                  70                  75                  80  


Gly Ala Gly Ala Thr Glu His Arg Ala Ala Cys Leu Ala Ser Gly Ile 
                85                  90                  95      


Pro Tyr Ser Thr Pro Phe Val Ala Leu Asn Arg Gln Cys Ser Ser Gly 
            100                 105                 110         


Leu Thr Ala Val Asn Asp Ile Ala Asn Lys Ile Lys Val Gly Gln Ile 
        115                 120                 125             


Asp Ile Gly Leu Ala Leu Gly Val Glu Ser Met Thr Asn Asn Tyr Lys 
    130                 135                 140                 


Asn Val Asn Pro Leu Gly Met Ile Ser Ser Glu Glu Leu Gln Lys Asn 
145                 150                 155                 160 


Arg Glu Ala Lys Lys Cys Leu Ile Pro Met Gly Ile Thr Asn Glu Asn 
                165                 170                 175     


Val Ala Ala Asn Phe Lys Ile Ser Arg Lys Asp Gln Asp Glu Phe Ala 
            180                 185                 190         


Ala Asn Ser Tyr Gln Lys Ala Tyr Lys Ala Lys Asn Glu Gly Leu Phe 
        195                 200                 205             


Glu Asp Glu Ile Leu Pro Ile Lys Leu Pro Asp Gly Ser Ile Cys Gln 
    210                 215                 220                 


Ser Asp Glu Gly Pro Arg Pro Asn Val Thr Ala Glu Ser Leu Leu Ser 
225                 230                 235                 240 


Ile Arg Pro Ala Phe Ile Lys Asp Arg Gly Thr Thr Thr Ala Gly Asn 
                245                 250                 255     


Ala Ser Gln Val Ser Asp Gly Val Ala Gly Val Leu Leu Ala Arg Arg 
            260                 265                 270         


Ser Val Ala Asn Gln Leu Asn Leu Pro Val Leu Gly Arg Tyr Ile Asp 
        275                 280                 285             


Phe Gln Thr Val Gly Val Pro Pro Glu Ile Met Gly Val Gly Pro Ala 
    290                 295                 300                 


Tyr Ala Ile Pro Lys Val Leu Glu Ala Thr Gly Leu Gln Val Gln Asp 
305                 310                 315                 320 


Ile Asp Ile Phe Glu Ile Asn Glu Ala Phe Ala Ala Gln Ala Leu Tyr 
                325                 330                 335     


Cys Ile His Lys Leu Gly Ile Asp Leu Asn Lys Val Asn Pro Arg Gly 
            340                 345                 350         


Gly Ala Ile Ala Leu Gly His Pro Leu Gly Cys Thr Gly Ala Arg Gln 
        355                 360                 365             


Val Ala Thr Ile Leu Arg Glu Leu Lys Lys Asp Gln Ile Gly Val Val 
    370                 375                 380                 


Ser Met Cys Ile Gly Thr Gly Met Gly Ala Ala Ala Ile Phe Ile Lys 
385                 390                 395                 400 


Glu 
    


<210>  48
<211>  398
<212>  PRT
<213>  Saccharomyces cerevisiae


<220>
<221>  MISC_FEATURE
<223>  S.cerevisiae C4-thiolase

<400>  48

Met Ser Gln Asn Val Tyr Ile Val Ser Thr Ala Arg Thr Pro Ile Gly 
1               5                   10                  15      


Ser Phe Gln Gly Ser Leu Ser Ser Lys Thr Ala Val Glu Leu Gly Ala 
            20                  25                  30          


Val Ala Leu Lys Gly Ala Leu Ala Lys Val Pro Glu Leu Asp Ala Ser 
        35                  40                  45              


Lys Asp Phe Asp Glu Ile Ile Phe Gly Asn Val Leu Ser Ala Asn Leu 
    50                  55                  60                  


Gly Gln Ala Pro Ala Arg Gln Val Ala Leu Ala Ala Gly Leu Ser Asn 
65                  70                  75                  80  


His Ile Val Ala Ser Thr Val Asn Lys Val Cys Ala Ser Ala Met Lys 
                85                  90                  95      


Ala Ile Ile Leu Gly Ala Gln Ser Ile Lys Cys Gly Asn Ala Asp Val 
            100                 105                 110         


Val Val Ala Gly Gly Cys Glu Ser Met Thr Asn Ala Pro Tyr Tyr Met 
        115                 120                 125             


Pro Ala Ala Arg Ala Gly Ala Lys Phe Gly Gln Thr Val Leu Val Asp 
    130                 135                 140                 


Gly Val Glu Arg Asp Gly Leu Asn Asp Ala Tyr Asp Gly Leu Ala Met 
145                 150                 155                 160 


Gly Val His Ala Glu Lys Cys Ala Arg Asp Trp Asp Ile Thr Arg Glu 
                165                 170                 175     


Gln Gln Asp Asn Phe Ala Ile Glu Ser Tyr Gln Lys Ser Gln Lys Ser 
            180                 185                 190         


Gln Lys Glu Gly Lys Phe Asp Asn Glu Ile Val Pro Val Thr Ile Lys 
        195                 200                 205             


Gly Phe Arg Gly Lys Pro Asp Thr Gln Val Thr Lys Asp Glu Glu Pro 
    210                 215                 220                 


Ala Arg Leu His Val Glu Lys Leu Arg Ser Ala Arg Thr Val Phe Gln 
225                 230                 235                 240 


Lys Glu Asn Gly Thr Val Thr Ala Ala Asn Ala Ser Pro Ile Asn Asp 
                245                 250                 255     


Gly Ala Ala Ala Val Ile Leu Val Ser Glu Lys Val Leu Lys Glu Lys 
            260                 265                 270         


Asn Leu Lys Pro Leu Ala Ile Ile Lys Gly Trp Gly Glu Ala Ala His 
        275                 280                 285             


Gln Pro Ala Asp Phe Thr Trp Ala Pro Ser Leu Ala Val Pro Lys Ala 
    290                 295                 300                 


Leu Lys His Ala Gly Ile Glu Asp Ile Asn Ser Val Asp Tyr Phe Glu 
305                 310                 315                 320 


Phe Asn Glu Ala Phe Ser Val Val Gly Leu Val Asn Thr Lys Ile Leu 
                325                 330                 335     


Lys Leu Asp Pro Ser Lys Val Asn Val Tyr Gly Gly Ala Val Ala Leu 
            340                 345                 350         


Gly His Pro Leu Gly Cys Ser Gly Ala Arg Val Val Val Thr Leu Leu 
        355                 360                 365             


Ser Ile Leu Gln Gln Glu Gly Gly Lys Ile Gly Val Ala Ala Ile Cys 
    370                 375                 380                 


Asn Gly Gly Gly Gly Ala Ser Ser Ile Val Ile Glu Lys Ile 
385                 390                 395             


<210>  49
<211>  394
<212>  PRT
<213>  Escherichia coli


<220>
<221>  MISC_FEATURE
<223>  E.coli C4 thiolase

<400>  49

Met Lys Asn Cys Val Ile Val Ser Ala Val Arg Thr Ala Ile Gly Ser 
1               5                   10                  15      


Phe Asn Gly Ser Leu Ala Ser Thr Ser Ala Ile Asp Leu Gly Ala Thr 
            20                  25                  30          


Val Ile Lys Ala Ala Ile Glu Arg Ala Lys Ile Asp Ser Gln His Val 
        35                  40                  45              


Asp Glu Val Ile Met Gly Asn Val Leu Gln Ala Gly Leu Gly Gln Asn 
    50                  55                  60                  


Pro Ala Arg Gln Ala Leu Leu Lys Ser Gly Leu Ala Glu Thr Val Cys 
65                  70                  75                  80  


Gly Phe Thr Val Asn Lys Val Cys Gly Ser Gly Leu Lys Ser Val Ala 
                85                  90                  95      


Leu Ala Ala Gln Ala Ile Gln Ala Gly Gln Ala Gln Ser Ile Val Ala 
            100                 105                 110         


Gly Gly Met Glu Asn Met Ser Leu Ala Pro Tyr Leu Leu Asp Ala Lys 
        115                 120                 125             


Ala Arg Ser Gly Tyr Arg Leu Gly Asp Gly Gln Val Tyr Asp Val Ile 
    130                 135                 140                 


Leu Arg Asp Gly Leu Met Cys Ala Thr His Gly Tyr His Met Gly Ile 
145                 150                 155                 160 


Thr Ala Glu Asn Val Ala Lys Glu Tyr Gly Ile Thr Arg Glu Met Gln 
                165                 170                 175     


Asp Glu Leu Ala Leu His Ser Gln Arg Lys Ala Ala Ala Ala Ile Glu 
            180                 185                 190         


Ser Gly Ala Phe Thr Ala Glu Ile Val Pro Val Asn Val Val Thr Arg 
        195                 200                 205             


Lys Lys Thr Phe Val Phe Ser Gln Asp Glu Phe Pro Lys Ala Asn Ser 
    210                 215                 220                 


Thr Ala Glu Ala Leu Gly Ala Leu Arg Pro Ala Phe Asp Lys Ala Gly 
225                 230                 235                 240 


Thr Val Thr Ala Gly Asn Ala Ser Gly Ile Asn Asp Gly Ala Ala Ala 
                245                 250                 255     


Leu Val Ile Met Glu Glu Ser Ala Ala Leu Ala Ala Gly Leu Thr Pro 
            260                 265                 270         


Leu Ala Arg Ile Lys Ser Tyr Ala Ser Gly Gly Val Pro Pro Ala Leu 
        275                 280                 285             


Met Gly Met Gly Pro Val Pro Ala Thr Gln Lys Ala Leu Gln Leu Ala 
    290                 295                 300                 


Gly Leu Gln Leu Ala Asp Ile Asp Leu Ile Glu Ala Asn Glu Ala Phe 
305                 310                 315                 320 


Ala Ala Gln Phe Leu Ala Val Gly Lys Asn Leu Gly Phe Asp Ser Glu 
                325                 330                 335     


Lys Val Asn Val Asn Gly Gly Ala Ile Ala Leu Gly His Pro Ile Gly 
            340                 345                 350         


Ala Ser Gly Ala Arg Ile Leu Val Thr Leu Leu His Ala Met Gln Ala 
        355                 360                 365             


Arg Asp Lys Thr Leu Gly Leu Ala Thr Leu Cys Ile Gly Gly Gly Gln 
    370                 375                 380                 


Gly Ile Ala Met Val Ile Glu Arg Leu Asn 
385                 390                 


<210>  50
<211>  393
<212>  PRT
<213>  Ralstonia eutropha

<400>  50

Met Thr Asp Val Val Ile Val Ser Ala Ala Arg Thr Ala Val Gly Lys 
1               5                   10                  15      


Phe Gly Gly Ser Leu Ala Lys Ile Pro Ala Pro Glu Leu Gly Ala Val 
            20                  25                  30          


Val Ile Lys Ala Ala Leu Glu Arg Ala Gly Val Lys Pro Glu Gln Val 
        35                  40                  45              


Ser Glu Val Ile Met Gly Gln Val Leu Thr Ala Gly Ser Gly Gln Asn 
    50                  55                  60                  


Pro Ala Arg Gln Ala Ala Ile Lys Ala Gly Leu Pro Ala Met Val Pro 
65                  70                  75                  80  


Ala Met Thr Ile Asn Lys Val Cys Gly Ser Gly Leu Lys Ala Val Met 
                85                  90                  95      


Leu Ala Ala Asn Ala Ile Met Ala Gly Asp Ala Glu Ile Val Val Ala 
            100                 105                 110         


Gly Gly Gln Glu Asn Met Ser Ala Ala Pro His Val Leu Pro Gly Ser 
        115                 120                 125             


Arg Asp Gly Phe Arg Met Gly Asp Ala Lys Leu Val Asp Thr Met Ile 
    130                 135                 140                 


Val Asp Gly Leu Trp Asp Val Tyr Asn Gln Tyr His Met Gly Ile Thr 
145                 150                 155                 160 


Ala Glu Asn Val Ala Lys Glu Tyr Gly Ile Thr Arg Glu Ala Gln Asp 
                165                 170                 175     


Glu Phe Ala Val Gly Ser Gln Asn Lys Ala Glu Ala Ala Gln Lys Ala 
            180                 185                 190         


Gly Lys Phe Asp Glu Glu Ile Val Pro Val Leu Ile Pro Gln Arg Lys 
        195                 200                 205             


Gly Asp Pro Val Ala Phe Lys Thr Asp Glu Phe Val Arg Gln Gly Ala 
    210                 215                 220                 


Thr Leu Asp Ser Met Ser Gly Leu Lys Pro Ala Phe Asp Lys Ala Gly 
225                 230                 235                 240 


Thr Val Thr Ala Ala Asn Ala Ser Gly Leu Asn Asp Gly Ala Ala Ala 
                245                 250                 255     


Val Val Val Met Ser Ala Ala Lys Ala Lys Glu Leu Gly Leu Thr Pro 
            260                 265                 270         


Leu Ala Thr Ile Lys Ser Tyr Ala Asn Ala Gly Val Asp Pro Lys Val 
        275                 280                 285             


Met Gly Met Gly Pro Val Pro Ala Ser Lys Arg Ala Leu Ser Arg Ala 
    290                 295                 300                 


Glu Trp Thr Pro Gln Asp Leu Asp Leu Met Glu Ile Asn Glu Ala Phe 
305                 310                 315                 320 


Ala Ala Gln Ala Leu Ala Val His Gln Gln Met Gly Trp Asp Thr Ser 
                325                 330                 335     


Lys Val Asn Val Asn Gly Gly Ala Ile Ala Ile Gly His Pro Ile Gly 
            340                 345                 350         


Ala Ser Gly Cys Arg Ile Leu Val Thr Leu Leu His Glu Met Lys Arg 
        355                 360                 365             


Arg Asp Ala Lys Lys Gly Leu Ala Ser Leu Cys Ile Gly Gly Gly Met 
    370                 375                 380                 


Gly Val Ala Leu Ala Val Glu Arg Lys 
385                 390             


<210>  51
<211>  387
<212>  PRT
<213>  Escherichia coli


<220>
<221>  MISC_FEATURE
<223>  E.coli C12 thiolase

<400>  51

Met Glu Gln Val Val Ile Val Asp Ala Ile Arg Thr Pro Met Gly Arg 
1               5                   10                  15      


Ser Lys Gly Gly Ala Phe Arg Asn Val Arg Ala Glu Asp Leu Ser Ala 
            20                  25                  30          


His Leu Met Arg Ser Leu Leu Ala Arg Asn Pro Ala Leu Glu Ala Ala 
        35                  40                  45              


Ala Leu Asp Asp Ile Tyr Trp Gly Cys Val Gln Gln Thr Leu Glu Gln 
    50                  55                  60                  


Gly Phe Asn Ile Ala Arg Asn Ala Ala Leu Leu Ala Glu Val Pro His 
65                  70                  75                  80  


Ser Val Pro Ala Val Thr Val Asn Arg Leu Cys Gly Ser Ser Met Gln 
                85                  90                  95      


Ala Leu His Asp Ala Ala Arg Met Ile Met Thr Gly Asp Ala Gln Ala 
            100                 105                 110         


Cys Leu Val Gly Gly Val Glu His Met Gly His Val Pro Met Ser His 
        115                 120                 125             


Gly Val Asp Phe His Pro Gly Leu Ser Arg Asn Val Ala Lys Ala Ala 
    130                 135                 140                 


Gly Met Met Gly Leu Thr Ala Glu Met Leu Ala Arg Met His Gly Ile 
145                 150                 155                 160 


Ser Arg Glu Met Gln Asp Ala Phe Ala Ala Arg Ser His Ala Arg Ala 
                165                 170                 175     


Trp Ala Ala Thr Gln Ser Ala Ala Phe Lys Asn Glu Ile Ile Pro Thr 
            180                 185                 190         


Gly Gly His Asp Ala Asp Gly Val Leu Lys Gln Phe Asn Tyr Asp Glu 
        195                 200                 205             


Val Ile Arg Pro Glu Thr Thr Val Glu Ala Leu Ala Thr Leu Arg Pro 
    210                 215                 220                 


Ala Phe Asp Pro Val Asn Gly Met Val Thr Ala Gly Thr Ser Ser Ala 
225                 230                 235                 240 


Leu Ser Asp Gly Ala Ala Ala Met Leu Val Met Ser Glu Ser Arg Ala 
                245                 250                 255     


His Glu Leu Gly Leu Lys Pro Arg Ala Arg Val Arg Ser Met Ala Val 
            260                 265                 270         


Val Gly Cys Asp Pro Ser Ile Met Gly Tyr Gly Pro Val Pro Ala Ser 
        275                 280                 285             


Lys Leu Ala Leu Lys Lys Ala Gly Leu Ser Ala Ser Asp Ile Gly Val 
    290                 295                 300                 


Phe Glu Met Asn Glu Ala Phe Ala Ala Gln Ile Leu Pro Cys Ile Lys 
305                 310                 315                 320 


Asp Leu Gly Leu Ile Glu Gln Ile Asp Glu Lys Ile Asn Leu Asn Gly 
                325                 330                 335     


Gly Ala Ile Ala Leu Gly His Pro Leu Gly Cys Ser Gly Ala Arg Ile 
            340                 345                 350         


Ser Thr Thr Leu Leu Asn Leu Met Glu Arg Lys Asp Val Gln Phe Gly 
        355                 360                 365             


Leu Ala Thr Met Cys Ile Gly Leu Gly Gln Gly Ile Ala Thr Val Phe 
    370                 375                 380                 


Glu Arg Val 
385         


<210>  52
<211>  897
<212>  PRT
<213>  Saccharomyces cerevisiae


<220>
<221>  MISC_FEATURE
<223>  FOX2 S.cerevisiae

<400>  52

Met Pro Gly Asn Leu Ser Phe Lys Asp Arg Val Val Val Ile Thr Gly 
1               5                   10                  15      


Ala Gly Gly Gly Leu Gly Lys Val Tyr Ala Leu Ala Tyr Ala Ser Arg 
            20                  25                  30          


Gly Ala Lys Val Val Val Asn Asp Leu Gly Gly Thr Leu Gly Gly Ser 
        35                  40                  45              


Gly His Asn Ser Lys Ala Ala Asp Leu Val Val Asp Glu Ile Lys Lys 
    50                  55                  60                  


Ala Gly Gly Ile Ala Val Ala Asn Tyr Asp Ser Val Asn Glu Asn Gly 
65                  70                  75                  80  


Glu Lys Ile Ile Glu Thr Ala Ile Lys Glu Phe Gly Arg Val Asp Val 
                85                  90                  95      


Leu Ile Asn Asn Ala Gly Ile Leu Arg Asp Val Ser Phe Ala Lys Met 
            100                 105                 110         


Thr Glu Arg Glu Phe Ala Ser Val Val Asp Val His Leu Thr Gly Gly 
        115                 120                 125             


Tyr Lys Leu Ser Arg Ala Ala Trp Pro Tyr Met Arg Ser Gln Lys Phe 
    130                 135                 140                 


Gly Arg Ile Ile Asn Thr Ala Ser Pro Ala Gly Leu Phe Gly Asn Phe 
145                 150                 155                 160 


Gly Gln Ala Asn Tyr Ser Ala Ala Lys Met Gly Leu Val Gly Leu Ala 
                165                 170                 175     


Glu Thr Leu Ala Lys Glu Gly Ala Lys Tyr Asn Ile Asn Val Asn Ser 
            180                 185                 190         


Ile Ala Pro Leu Ala Arg Ser Arg Met Thr Glu Asn Val Leu Pro Pro 
        195                 200                 205             


His Ile Leu Lys Gln Leu Gly Pro Glu Lys Ile Val Pro Leu Val Leu 
    210                 215                 220                 


Tyr Leu Thr His Glu Ser Thr Lys Val Ser Asn Ser Ile Phe Glu Leu 
225                 230                 235                 240 


Ala Ala Gly Phe Phe Gly Gln Leu Arg Trp Glu Arg Ser Ser Gly Gln 
                245                 250                 255     


Ile Phe Asn Pro Asp Pro Lys Thr Tyr Thr Pro Glu Ala Ile Leu Asn 
            260                 265                 270         


Lys Trp Lys Glu Ile Thr Asp Tyr Arg Asp Lys Pro Phe Asn Lys Thr 
        275                 280                 285             


Gln His Pro Tyr Gln Leu Ser Asp Tyr Asn Asp Leu Ile Thr Lys Ala 
    290                 295                 300                 


Lys Lys Leu Pro Pro Asn Glu Gln Gly Ser Val Lys Ile Lys Ser Leu 
305                 310                 315                 320 


Cys Asn Lys Val Val Val Val Thr Gly Ala Gly Gly Gly Leu Gly Lys 
                325                 330                 335     


Ser His Ala Ile Trp Phe Ala Arg Tyr Gly Ala Lys Val Val Val Asn 
            340                 345                 350         


Asp Ile Lys Asp Pro Phe Ser Val Val Glu Glu Ile Asn Lys Leu Tyr 
        355                 360                 365             


Gly Glu Gly Thr Ala Ile Pro Asp Ser His Asp Val Val Thr Glu Ala 
    370                 375                 380                 


Pro Leu Ile Ile Gln Thr Ala Ile Ser Lys Phe Gln Arg Val Asp Ile 
385                 390                 395                 400 


Leu Val Asn Asn Ala Gly Ile Leu Arg Asp Lys Ser Phe Leu Lys Met 
                405                 410                 415     


Lys Asp Glu Glu Trp Phe Ala Val Leu Lys Val His Leu Phe Ser Thr 
            420                 425                 430         


Phe Ser Leu Ser Lys Ala Val Trp Pro Ile Phe Thr Lys Gln Lys Ser 
        435                 440                 445             


Gly Phe Ile Ile Asn Thr Thr Ser Thr Ser Gly Ile Tyr Gly Asn Phe 
    450                 455                 460                 


Gly Gln Ala Asn Tyr Ala Ala Ala Lys Ala Ala Ile Leu Gly Phe Ser 
465                 470                 475                 480 


Lys Thr Ile Ala Leu Glu Gly Ala Lys Arg Gly Ile Ile Val Asn Val 
                485                 490                 495     


Ile Ala Pro His Ala Glu Thr Ala Met Thr Lys Thr Ile Phe Ser Glu 
            500                 505                 510         


Lys Glu Leu Ser Asn His Phe Asp Ala Ser Gln Val Ser Pro Leu Val 
        515                 520                 525             


Val Leu Leu Ala Ser Glu Glu Leu Gln Lys Tyr Ser Gly Arg Arg Val 
    530                 535                 540                 


Ile Gly Gln Leu Phe Glu Val Gly Gly Gly Trp Cys Gly Gln Thr Arg 
545                 550                 555                 560 


Trp Gln Arg Ser Ser Gly Tyr Val Ser Ile Lys Glu Thr Ile Glu Pro 
                565                 570                 575     


Glu Glu Ile Lys Glu Asn Trp Asn His Ile Thr Asp Phe Ser Arg Asn 
            580                 585                 590         


Thr Ile Asn Pro Ser Ser Thr Glu Glu Ser Ser Met Ala Thr Leu Gln 
        595                 600                 605             


Ala Val Gln Lys Ala His Ser Ser Lys Glu Leu Asp Asp Gly Leu Phe 
    610                 615                 620                 


Lys Tyr Thr Thr Lys Asp Cys Ile Leu Tyr Asn Leu Gly Leu Gly Cys 
625                 630                 635                 640 


Thr Ser Lys Glu Leu Lys Tyr Thr Tyr Glu Asn Asp Pro Asp Phe Gln 
                645                 650                 655     


Val Leu Pro Thr Phe Ala Val Ile Pro Phe Met Gln Ala Thr Ala Thr 
            660                 665                 670         


Leu Ala Met Asp Asn Leu Val Asp Asn Phe Asn Tyr Ala Met Leu Leu 
        675                 680                 685             


His Gly Glu Gln Tyr Phe Lys Leu Cys Thr Pro Thr Met Pro Ser Asn 
    690                 695                 700                 


Gly Thr Leu Lys Thr Leu Ala Lys Pro Leu Gln Val Leu Asp Lys Asn 
705                 710                 715                 720 


Gly Lys Ala Ala Leu Val Val Gly Gly Phe Glu Thr Tyr Asp Ile Lys 
                725                 730                 735     


Thr Lys Lys Leu Ile Ala Tyr Asn Glu Gly Ser Phe Phe Ile Arg Gly 
            740                 745                 750         


Ala His Val Pro Pro Glu Lys Glu Val Arg Asp Gly Lys Arg Ala Lys 
        755                 760                 765             


Phe Ala Val Gln Asn Phe Glu Val Pro His Gly Lys Val Pro Asp Phe 
    770                 775                 780                 


Glu Ala Glu Ile Ser Thr Asn Lys Asp Gln Ala Ala Leu Tyr Arg Leu 
785                 790                 795                 800 


Ser Gly Asp Phe Asn Pro Leu His Ile Asp Pro Thr Leu Ala Lys Ala 
                805                 810                 815     


Val Lys Phe Pro Thr Pro Ile Leu His Gly Leu Cys Thr Leu Gly Ile 
            820                 825                 830         


Ser Ala Lys Ala Leu Phe Glu His Tyr Gly Pro Tyr Glu Glu Leu Lys 
        835                 840                 845             


Val Arg Phe Thr Asn Val Val Phe Pro Gly Asp Thr Leu Lys Val Lys 
    850                 855                 860                 


Ala Trp Lys Gln Gly Ser Val Val Val Phe Gln Thr Ile Asp Thr Thr 
865                 870                 875                 880 


Arg Asn Val Ile Val Leu Asp Asn Ala Ala Val Lys Leu Ser Gln Ala 
                885                 890                 895     


Lys 
    


<210>  53
<211>  282
<212>  PRT
<213>  Clostridium acetobutylicum

<400>  53

Met Lys Lys Val Cys Val Ile Gly Ala Gly Thr Met Gly Ser Gly Ile 
1               5                   10                  15      


Ala Gln Ala Phe Ala Ala Lys Gly Phe Glu Val Val Leu Arg Asp Ile 
            20                  25                  30          


Lys Asp Glu Phe Val Asp Arg Gly Leu Asp Phe Ile Asn Lys Asn Leu 
        35                  40                  45              


Ser Lys Leu Val Lys Lys Gly Lys Ile Glu Glu Ala Thr Lys Val Glu 
    50                  55                  60                  


Ile Leu Thr Arg Ile Ser Gly Thr Val Asp Leu Asn Met Ala Ala Asp 
65                  70                  75                  80  


Cys Asp Leu Val Ile Glu Ala Ala Val Glu Arg Met Asp Ile Lys Lys 
                85                  90                  95      


Gln Ile Phe Ala Asp Leu Asp Asn Ile Cys Lys Pro Glu Thr Ile Leu 
            100                 105                 110         


Ala Ser Asn Thr Ser Ser Leu Ser Ile Thr Glu Val Ala Ser Ala Thr 
        115                 120                 125             


Lys Arg Pro Asp Lys Val Ile Gly Met His Phe Phe Asn Pro Ala Pro 
    130                 135                 140                 


Val Met Lys Leu Val Glu Val Ile Arg Gly Ile Ala Thr Ser Gln Glu 
145                 150                 155                 160 


Thr Phe Asp Ala Val Lys Glu Thr Ser Ile Ala Ile Gly Lys Asp Pro 
                165                 170                 175     


Val Glu Val Ala Glu Ala Pro Gly Phe Val Val Asn Arg Ile Leu Ile 
            180                 185                 190         


Pro Met Ile Asn Glu Ala Val Gly Ile Leu Ala Glu Gly Ile Ala Ser 
        195                 200                 205             


Val Glu Asp Ile Asp Lys Ala Met Lys Leu Gly Ala Asn His Pro Met 
    210                 215                 220                 


Gly Pro Leu Glu Leu Gly Asp Phe Ile Gly Leu Asp Ile Cys Leu Ala 
225                 230                 235                 240 


Ile Met Asp Val Leu Tyr Ser Glu Thr Gly Asp Ser Lys Tyr Arg Pro 
                245                 250                 255     


His Thr Leu Leu Lys Lys Tyr Val Arg Ala Gly Trp Leu Gly Arg Lys 
            260                 265                 270         


Ser Gly Lys Gly Phe Tyr Asp Tyr Ser Lys 
        275                 280         


<210>  54
<211>  282
<212>  PRT
<213>  Clostridium beijerinckii

<400>  54

Met Lys Lys Ile Phe Val Leu Gly Ala Gly Thr Met Gly Ala Gly Ile 
1               5                   10                  15      


Val Gln Ala Phe Ala Gln Lys Gly Cys Glu Val Ile Val Arg Asp Ile 
            20                  25                  30          


Lys Glu Glu Phe Val Asp Arg Gly Ile Ala Gly Ile Thr Lys Gly Leu 
        35                  40                  45              


Glu Lys Gln Val Ala Lys Gly Lys Met Ser Glu Glu Asp Lys Glu Ala 
    50                  55                  60                  


Ile Leu Ser Arg Ile Ser Gly Thr Thr Asp Met Lys Leu Ala Ala Asp 
65                  70                  75                  80  


Cys Asp Leu Val Val Glu Ala Ala Ile Glu Asn Met Lys Ile Lys Lys 
                85                  90                  95      


Glu Ile Phe Ala Glu Leu Asp Gly Ile Cys Lys Pro Glu Ala Ile Leu 
            100                 105                 110         


Ala Ser Asn Thr Ser Ser Leu Ser Ile Thr Glu Val Ala Ser Ala Thr 
        115                 120                 125             


Lys Arg Pro Asp Lys Val Ile Gly Met His Phe Phe Asn Pro Ala Pro 
    130                 135                 140                 


Val Met Lys Leu Val Glu Ile Ile Lys Gly Ile Ala Thr Ser Gln Glu 
145                 150                 155                 160 


Thr Phe Asp Ala Val Lys Glu Leu Ser Val Ala Ile Gly Lys Glu Pro 
                165                 170                 175     


Val Glu Val Ala Glu Ala Pro Gly Phe Val Val Asn Arg Ile Leu Ile 
            180                 185                 190         


Pro Met Ile Asn Glu Ala Ser Phe Ile Leu Gln Glu Gly Ile Ala Ser 
        195                 200                 205             


Val Glu Asp Ile Asp Thr Ala Met Lys Tyr Gly Ala Asn His Pro Met 
    210                 215                 220                 


Gly Pro Leu Ala Leu Gly Asp Leu Ile Gly Leu Asp Val Cys Leu Ala 
225                 230                 235                 240 


Ile Met Asp Val Leu Phe Thr Glu Thr Gly Asp Asn Lys Tyr Arg Ala 
                245                 250                 255     


Ser Ser Ile Leu Arg Lys Tyr Val Arg Ala Gly Trp Leu Gly Arg Lys 
            260                 265                 270         


Ser Gly Lys Gly Phe Tyr Asp Tyr Ser Lys 
        275                 280         


<210>  55
<211>  729
<212>  PRT
<213>  Escherichia coli

<400>  55

Met Leu Tyr Lys Gly Asp Thr Leu Tyr Leu Asp Trp Leu Glu Asp Gly 
1               5                   10                  15      


Ile Ala Glu Leu Val Phe Asp Ala Pro Gly Ser Val Asn Lys Leu Asp 
            20                  25                  30          


Thr Ala Thr Val Ala Ser Leu Gly Glu Ala Ile Gly Val Leu Glu Gln 
        35                  40                  45              


Gln Ser Asp Leu Lys Gly Leu Leu Leu Arg Ser Asn Lys Ala Ala Phe 
    50                  55                  60                  


Ile Val Gly Ala Asp Ile Thr Glu Phe Leu Ser Leu Phe Leu Val Pro 
65                  70                  75                  80  


Glu Glu Gln Leu Ser Gln Trp Leu His Phe Ala Asn Ser Val Phe Asn 
                85                  90                  95      


Arg Leu Glu Asp Leu Pro Val Pro Thr Ile Ala Ala Val Asn Gly Tyr 
            100                 105                 110         


Ala Leu Gly Gly Gly Cys Glu Cys Val Leu Ala Thr Asp Tyr Arg Leu 
        115                 120                 125             


Ala Thr Pro Asp Leu Arg Ile Gly Leu Pro Glu Thr Lys Leu Gly Ile 
    130                 135                 140                 


Met Pro Gly Phe Gly Gly Ser Val Arg Met Pro Arg Met Leu Gly Ala 
145                 150                 155                 160 


Asp Ser Ala Leu Glu Ile Ile Ala Ala Gly Lys Asp Val Gly Ala Asp 
                165                 170                 175     


Gln Ala Leu Lys Ile Gly Leu Val Asp Gly Val Val Lys Ala Glu Lys 
            180                 185                 190         


Leu Val Glu Gly Ala Lys Ala Val Leu Arg Gln Ala Ile Asn Gly Asp 
        195                 200                 205             


Leu Asp Trp Lys Ala Lys Arg Gln Pro Lys Leu Glu Pro Leu Lys Leu 
    210                 215                 220                 


Ser Lys Ile Glu Ala Thr Met Ser Phe Thr Ile Ala Lys Gly Met Val 
225                 230                 235                 240 


Ala Gln Thr Ala Gly Lys His Tyr Pro Ala Pro Ile Thr Ala Val Lys 
                245                 250                 255     


Thr Ile Glu Ala Ala Ala Arg Phe Gly Arg Glu Glu Ala Leu Asn Leu 
            260                 265                 270         


Glu Asn Lys Ser Phe Val Pro Leu Ala His Thr Asn Glu Ala Arg Ala 
        275                 280                 285             


Leu Val Gly Ile Phe Leu Asn Asp Gln Tyr Val Lys Gly Lys Ala Lys 
    290                 295                 300                 


Lys Leu Thr Lys Asp Val Glu Thr Pro Lys Gln Ala Ala Val Leu Gly 
305                 310                 315                 320 


Ala Gly Ile Met Gly Gly Gly Ile Ala Tyr Gln Ser Ala Trp Lys Gly 
                325                 330                 335     


Val Pro Val Val Met Lys Asp Ile Asn Asp Lys Ser Leu Thr Leu Gly 
            340                 345                 350         


Met Thr Glu Ala Ala Lys Leu Leu Asn Lys Gln Leu Glu Arg Gly Lys 
        355                 360                 365             


Ile Asp Gly Leu Lys Leu Ala Gly Val Ile Ser Thr Ile His Pro Thr 
    370                 375                 380                 


Leu Asp Tyr Ala Gly Phe Asp Arg Val Asp Ile Val Val Glu Ala Val 
385                 390                 395                 400 


Val Glu Asn Pro Lys Val Lys Lys Ala Val Leu Ala Glu Thr Glu Gln 
                405                 410                 415     


Lys Val Arg Gln Asp Thr Val Leu Ala Ser Asn Thr Ser Thr Ile Pro 
            420                 425                 430         


Ile Ser Glu Leu Ala Asn Ala Leu Glu Arg Pro Glu Asn Phe Cys Gly 
        435                 440                 445             


Met His Phe Phe Asn Pro Val His Arg Met Pro Leu Val Glu Ile Ile 
    450                 455                 460                 


Arg Gly Glu Lys Ser Ser Asp Glu Thr Ile Ala Lys Val Val Ala Trp 
465                 470                 475                 480 


Ala Ser Lys Met Gly Lys Thr Pro Ile Val Val Asn Asp Cys Pro Gly 
                485                 490                 495     


Phe Phe Val Asn Arg Val Leu Phe Pro Tyr Phe Ala Gly Phe Ser Gln 
            500                 505                 510         


Leu Leu Arg Asp Gly Ala Asp Phe Arg Lys Ile Asp Lys Val Met Glu 
        515                 520                 525             


Lys Gln Phe Gly Trp Pro Met Gly Pro Ala Tyr Leu Leu Asp Val Val 
    530                 535                 540                 


Gly Ile Asp Thr Ala His His Ala Gln Ala Val Met Ala Ala Gly Phe 
545                 550                 555                 560 


Pro Gln Arg Met Gln Lys Asp Tyr Arg Asp Ala Ile Asp Ala Leu Phe 
                565                 570                 575     


Asp Ala Asn Arg Phe Gly Gln Lys Asn Gly Leu Gly Phe Trp Arg Tyr 
            580                 585                 590         


Lys Glu Asp Ser Lys Gly Lys Pro Lys Lys Glu Glu Asp Ala Ala Val 
        595                 600                 605             


Glu Asp Leu Leu Ala Glu Val Ser Gln Pro Lys Arg Asp Phe Ser Glu 
    610                 615                 620                 


Glu Glu Ile Ile Ala Arg Met Met Ile Pro Met Val Asn Glu Val Val 
625                 630                 635                 640 


Arg Cys Leu Glu Glu Gly Ile Ile Ala Thr Pro Ala Glu Ala Asp Met 
                645                 650                 655     


Ala Leu Val Tyr Gly Leu Gly Phe Pro Pro Phe His Gly Gly Ala Phe 
            660                 665                 670         


Arg Trp Leu Asp Thr Leu Gly Ser Ala Lys Tyr Leu Asp Met Ala Gln 
        675                 680                 685             


Gln Tyr Gln His Leu Gly Pro Leu Tyr Glu Val Pro Glu Gly Leu Arg 
    690                 695                 700                 


Asn Lys Ala Arg His Asn Glu Pro Tyr Tyr Pro Pro Val Glu Pro Ala 
705                 710                 715                 720 


Arg Pro Val Gly Asp Leu Lys Thr Ala 
                725                 


<210>  56
<211>  261
<212>  PRT
<213>  Clostridium acetobutylicum

<400>  56

Met Glu Leu Asn Asn Val Ile Leu Glu Lys Glu Gly Lys Val Ala Val 
1               5                   10                  15      


Val Thr Ile Asn Arg Pro Lys Ala Leu Asn Ala Leu Asn Ser Asp Thr 
            20                  25                  30          


Leu Lys Glu Met Asp Tyr Val Ile Gly Glu Ile Glu Asn Asp Ser Glu 
        35                  40                  45              


Val Leu Ala Val Ile Leu Thr Gly Ala Gly Glu Lys Ser Phe Val Ala 
    50                  55                  60                  


Gly Ala Asp Ile Ser Glu Met Lys Glu Met Asn Thr Ile Glu Gly Arg 
65                  70                  75                  80  


Lys Phe Gly Ile Leu Gly Asn Lys Val Phe Arg Arg Leu Glu Leu Leu 
                85                  90                  95      


Glu Lys Pro Val Ile Ala Ala Val Asn Gly Phe Ala Leu Gly Gly Gly 
            100                 105                 110         


Cys Glu Ile Ala Met Ser Cys Asp Ile Arg Ile Ala Ser Ser Asn Ala 
        115                 120                 125             


Arg Phe Gly Gln Pro Glu Val Gly Leu Gly Ile Thr Pro Gly Phe Gly 
    130                 135                 140                 


Gly Thr Gln Arg Leu Ser Arg Leu Val Gly Met Gly Met Ala Lys Gln 
145                 150                 155                 160 


Leu Ile Phe Thr Ala Gln Asn Ile Lys Ala Asp Glu Ala Leu Arg Ile 
                165                 170                 175     


Gly Leu Val Asn Lys Val Val Glu Pro Ser Glu Leu Met Asn Thr Ala 
            180                 185                 190         


Lys Glu Ile Ala Asn Lys Ile Val Ser Asn Ala Pro Val Ala Val Lys 
        195                 200                 205             


Leu Ser Lys Gln Ala Ile Asn Arg Gly Met Gln Cys Asp Ile Asp Thr 
    210                 215                 220                 


Ala Leu Ala Phe Glu Ser Glu Ala Phe Gly Glu Cys Phe Ser Thr Glu 
225                 230                 235                 240 


Asp Gln Lys Asp Ala Met Thr Ala Phe Ile Glu Lys Arg Lys Ile Glu 
                245                 250                 255     


Gly Phe Lys Asn Arg 
            260     


<210>  57
<211>  258
<212>  PRT
<213>  Clostridium beijerinckii

<400>  57

Met Glu Asn Ile Lys Val Lys Glu Glu Asn Gly Val Ser Val Ile Cys 
1               5                   10                  15      


Ile Asp Arg Pro Lys Ser Leu Asn Ala Leu Asn Thr Gln Thr Leu Lys 
            20                  25                  30          


Glu Leu Gly Gln Val Ile Asn Asp Ile Ser Glu Arg Lys Asp Ile Tyr 
        35                  40                  45              


Thr Val Ile Ile Thr Gly Ser Gly Glu Lys Ala Phe Val Ala Gly Ala 
    50                  55                  60                  


Asp Ile Thr Glu Met Lys Ser Lys Ser Ala Ile Glu Gly Arg Glu Met 
65                  70                  75                  80  


Ala Lys Leu Ala Gln Lys Val Phe Ser Asn Ile Glu Asn Met Pro Gln 
                85                  90                  95      


Val Val Ile Ala Ala Val Asn Gly Tyr Ala Leu Gly Gly Gly Cys Glu 
            100                 105                 110         


Leu Ser Met Ala Cys Asp Ile Arg Leu Ala Ser Thr Asn Ala Lys Phe 
        115                 120                 125             


Gly Gln Pro Glu Val Gly Leu Gly Ile Ile Pro Gly Phe Ala Gly Thr 
    130                 135                 140                 


Gln Arg Leu Pro Arg Leu Val Gly Lys Gly Ile Ala Lys Glu Leu Ile 
145                 150                 155                 160 


Phe Thr Thr Asp Met Ile Asp Ala Lys Glu Ala Tyr Arg Ile Gly Leu 
                165                 170                 175     


Val Asn Lys Val Tyr Glu Pro Glu Glu Leu Met Glu Lys Thr Ile Glu 
            180                 185                 190         


Leu Ala Gln Lys Ile Met Lys Lys Gly Leu Phe Ala Val Ser Leu Ala 
        195                 200                 205             


Lys Ser Ala Ile Asn Asn Gly Leu Asn Met Asp Thr Glu Ser Ala Tyr 
    210                 215                 220                 


Ala Phe Glu Ala Asn Leu Phe Gly Leu Cys Phe Ser Thr Asp Asp Gln 
225                 230                 235                 240 


Thr Glu Gly Met Ser Ala Phe Ile Glu Lys Arg Lys Ala Leu Phe Lys 
                245                 250                 255     


Gly Cys 
        


<210>  58
<211>  397
<212>  PRT
<213>  Treponema denticola

<400>  58

Met Ile Val Lys Pro Met Val Arg Asn Asn Ile Cys Leu Asn Ala His 
1               5                   10                  15      


Pro Gln Gly Cys Lys Lys Gly Val Glu Asp Gln Ile Glu Tyr Thr Lys 
            20                  25                  30          


Lys Arg Ile Thr Ala Glu Val Lys Ala Gly Ala Lys Ala Pro Lys Asn 
        35                  40                  45              


Val Leu Val Leu Gly Cys Ser Asn Gly Tyr Gly Leu Ala Ser Arg Ile 
    50                  55                  60                  


Thr Ala Ala Phe Gly Tyr Gly Ala Ala Thr Ile Gly Val Ser Phe Glu 
65                  70                  75                  80  


Lys Ala Gly Ser Glu Thr Lys Tyr Gly Thr Pro Gly Trp Tyr Asn Asn 
                85                  90                  95      


Leu Ala Phe Asp Glu Ala Ala Lys Arg Glu Gly Leu Tyr Ser Val Thr 
            100                 105                 110         


Ile Asp Gly Asp Ala Phe Ser Asp Glu Ile Lys Ala Gln Val Ile Glu 
        115                 120                 125             


Glu Ala Lys Lys Lys Gly Ile Lys Phe Asp Leu Ile Val Tyr Ser Leu 
    130                 135                 140                 


Ala Ser Pro Val Arg Thr Asp Pro Asp Thr Gly Ile Met His Lys Ser 
145                 150                 155                 160 


Val Leu Lys Pro Phe Gly Lys Thr Phe Thr Gly Lys Thr Val Asp Pro 
                165                 170                 175     


Phe Thr Gly Glu Leu Lys Glu Ile Ser Ala Glu Pro Ala Asn Asp Glu 
            180                 185                 190         


Glu Ala Ala Ala Thr Val Lys Val Met Gly Gly Glu Asp Trp Glu Arg 
        195                 200                 205             


Trp Ile Lys Gln Leu Ser Lys Glu Gly Leu Leu Glu Glu Gly Cys Ile 
    210                 215                 220                 


Thr Leu Ala Tyr Ser Tyr Ile Gly Pro Glu Ala Thr Gln Ala Leu Tyr 
225                 230                 235                 240 


Arg Lys Gly Thr Ile Gly Lys Ala Lys Glu His Leu Glu Ala Thr Ala 
                245                 250                 255     


His Arg Leu Asn Lys Glu Asn Pro Ser Ile Arg Ala Phe Val Ser Val 
            260                 265                 270         


Asn Lys Gly Leu Val Thr Arg Ala Ser Ala Val Ile Pro Val Ile Pro 
        275                 280                 285             


Leu Tyr Leu Ala Ser Leu Phe Lys Val Met Lys Glu Lys Gly Asn His 
    290                 295                 300                 


Glu Gly Cys Ile Glu Gln Ile Thr Arg Leu Tyr Ala Glu Arg Leu Tyr 
305                 310                 315                 320 


Arg Lys Asp Gly Thr Ile Pro Val Asp Glu Glu Asn Arg Ile Arg Ile 
                325                 330                 335     


Asp Asp Trp Glu Leu Glu Glu Asp Val Gln Lys Ala Val Ser Ala Leu 
            340                 345                 350         


Met Glu Lys Val Thr Gly Glu Asn Ala Glu Ser Leu Thr Asp Leu Ala 
        355                 360                 365             


Gly Tyr Arg His Asp Phe Leu Ala Ser Asn Gly Phe Asp Val Glu Gly 
    370                 375                 380                 


Ile Asn Tyr Glu Ala Glu Val Glu Arg Phe Asp Arg Ile 
385                 390                 395         


<210>  59
<211>  539
<212>  PRT
<213>  Euglena gracilis

<400>  59

Met Ser Cys Pro Ala Ser Pro Ser Ala Ala Val Val Ser Ala Gly Ala 
1               5                   10                  15      


Leu Cys Leu Cys Val Ala Thr Val Leu Leu Ala Thr Gly Ser Asn Pro 
            20                  25                  30          


Thr Ala Leu Ser Thr Ala Ser Thr Arg Ser Pro Thr Ser Leu Val Arg 
        35                  40                  45              


Gly Val Asp Arg Gly Leu Met Arg Pro Thr Thr Ala Ala Ala Leu Thr 
    50                  55                  60                  


Thr Met Arg Glu Val Pro Gln Met Ala Glu Gly Phe Ser Gly Glu Ala 
65                  70                  75                  80  


Thr Ser Ala Trp Ala Ala Ala Gly Pro Gln Trp Ala Ala Pro Leu Val 
                85                  90                  95      


Ala Ala Ala Ser Ser Ala Leu Ala Leu Trp Trp Trp Ala Ala Arg Arg 
            100                 105                 110         


Ser Val Arg Arg Pro Leu Ala Ala Leu Ala Glu Leu Pro Thr Ala Val 
        115                 120                 125             


Thr His Leu Ala Pro Pro Met Ala Met Phe Thr Thr Thr Ala Lys Val 
    130                 135                 140                 


Ile Gln Pro Lys Ile Arg Gly Phe Ile Cys Thr Thr Thr His Pro Ile 
145                 150                 155                 160 


Gly Cys Glu Lys Arg Val Gln Glu Glu Ile Ala Tyr Ala Arg Ala His 
                165                 170                 175     


Pro Pro Thr Ser Pro Gly Pro Lys Arg Val Leu Val Ile Gly Cys Ser 
            180                 185                 190         


Thr Gly Tyr Gly Leu Ser Thr Arg Ile Thr Ala Ala Phe Gly Tyr Gln 
        195                 200                 205             


Ala Ala Thr Leu Gly Val Phe Leu Ala Gly Pro Pro Thr Lys Gly Arg 
    210                 215                 220                 


Pro Ala Ala Ala Gly Trp Tyr Asn Thr Val Ala Phe Glu Lys Ala Ala 
225                 230                 235                 240 


Leu Glu Ala Gly Leu Tyr Ala Arg Ser Leu Asn Gly Asp Ala Phe Asp 
                245                 250                 255     


Ser Thr Thr Lys Ala Arg Thr Val Glu Ala Ile Lys Arg Asp Leu Gly 
            260                 265                 270         


Thr Val Asp Leu Val Val Tyr Ser Ile Ala Ala Pro Lys Arg Thr Asp 
        275                 280                 285             


Pro Ala Thr Gly Val Leu His Lys Ala Cys Leu Lys Pro Ile Gly Ala 
    290                 295                 300                 


Thr Tyr Thr Asn Arg Thr Val Asn Thr Asp Lys Ala Glu Val Thr Asp 
305                 310                 315                 320 


Val Ser Ile Glu Pro Ala Ser Pro Glu Glu Ile Ala Asp Thr Val Lys 
                325                 330                 335     


Val Met Gly Gly Glu Asp Trp Glu Leu Trp Ile Gln Ala Leu Ser Glu 
            340                 345                 350         


Ala Gly Val Leu Ala Glu Gly Ala Lys Thr Val Ala Tyr Ser Tyr Ile 
        355                 360                 365             


Gly Pro Glu Met Thr Trp Pro Val Tyr Trp Ser Gly Thr Ile Gly Glu 
    370                 375                 380                 


Ala Lys Lys Asp Val Glu Lys Ala Ala Lys Arg Ile Thr Gln Gln Tyr 
385                 390                 395                 400 


Gly Cys Pro Ala Tyr Pro Val Val Ala Lys Ala Leu Val Thr Gln Ala 
                405                 410                 415     


Ser Ser Ala Ile Pro Val Val Pro Leu Tyr Ile Cys Leu Leu Tyr Arg 
            420                 425                 430         


Val Met Lys Glu Lys Gly Thr His Glu Gly Cys Ile Glu Gln Met Val 
        435                 440                 445             


Arg Leu Leu Thr Thr Lys Leu Tyr Pro Glu Asn Gly Ala Pro Ile Val 
    450                 455                 460                 


Asp Glu Ala Gly Arg Val Arg Val Asp Asp Trp Glu Met Ala Glu Asp 
465                 470                 475                 480 


Val Gln Gln Ala Val Lys Asp Leu Trp Ser Gln Val Ser Thr Ala Asn 
                485                 490                 495     


Leu Lys Asp Ile Ser Asp Phe Ala Gly Tyr Gln Thr Glu Phe Leu Arg 
            500                 505                 510         


Leu Phe Gly Phe Gly Ile Asp Gly Val Asp Tyr Asp Gln Pro Val Asp 
        515                 520                 525             


Val Glu Ala Asp Leu Pro Ser Ala Ala Gln Gln 
    530                 535                 


<210>  60
<211>  2346
<212>  PRT
<213>  Homo sapiens

<400>  60

Met Asp Glu Pro Ser Pro Leu Ala Gln Pro Leu Glu Leu Asn Gln His 
1               5                   10                  15      


Ser Arg Phe Ile Ile Gly Ser Val Ser Glu Asp Asn Ser Glu Asp Glu 
            20                  25                  30          


Ile Ser Asn Leu Val Lys Leu Asp Leu Leu Glu Glu Lys Glu Gly Ser 
        35                  40                  45              


Leu Ser Pro Ala Ser Val Gly Ser Asp Thr Leu Ser Asp Leu Gly Ile 
    50                  55                  60                  


Ser Ser Leu Gln Asp Gly Leu Ala Leu His Ile Arg Ser Ser Met Ser 
65                  70                  75                  80  


Gly Leu His Leu Val Lys Gln Gly Arg Asp Arg Lys Lys Ile Asp Ser 
                85                  90                  95      


Gln Arg Asp Phe Thr Val Ala Ser Pro Ala Glu Phe Val Thr Arg Phe 
            100                 105                 110         


Gly Gly Asn Lys Val Ile Glu Lys Val Leu Ile Ala Asn Asn Gly Ile 
        115                 120                 125             


Ala Ala Val Lys Cys Met Arg Ser Ile Arg Arg Trp Ser Tyr Glu Met 
    130                 135                 140                 


Phe Arg Asn Glu Arg Ala Ile Arg Phe Val Val Met Val Thr Pro Glu 
145                 150                 155                 160 


Asp Leu Lys Ala Asn Ala Glu Tyr Ile Lys Met Ala Asp His Tyr Val 
                165                 170                 175     


Pro Val Pro Gly Gly Pro Asn Asn Asn Asn Tyr Ala Asn Val Glu Leu 
            180                 185                 190         


Ile Leu Asp Ile Ala Lys Arg Ile Pro Val Gln Ala Val Trp Ala Gly 
        195                 200                 205             


Trp Gly His Ala Ser Glu Asn Pro Lys Leu Pro Glu Leu Leu Leu Lys 
    210                 215                 220                 


Asn Gly Ile Ala Phe Met Gly Pro Pro Ser Gln Ala Met Trp Ala Leu 
225                 230                 235                 240 


Gly Asp Lys Ile Ala Ser Ser Ile Val Ala Gln Thr Ala Gly Ile Pro 
                245                 250                 255     


Thr Leu Pro Trp Ser Gly Ser Gly Leu Arg Val Asp Trp Gln Glu Asn 
            260                 265                 270         


Asp Phe Ser Lys Arg Ile Leu Asn Val Pro Gln Glu Leu Tyr Glu Lys 
        275                 280                 285             


Gly Tyr Val Lys Asp Val Asp Asp Gly Leu Gln Ala Ala Glu Glu Val 
    290                 295                 300                 


Gly Tyr Pro Val Met Ile Lys Ala Ser Glu Gly Gly Gly Gly Lys Gly 
305                 310                 315                 320 


Ile Arg Lys Val Asn Asn Ala Asp Asp Phe Pro Asn Leu Phe Arg Gln 
                325                 330                 335     


Val Gln Ala Glu Val Pro Gly Ser Pro Ile Phe Val Met Arg Leu Ala 
            340                 345                 350         


Lys Gln Ser Arg His Leu Glu Val Gln Ile Leu Ala Asp Gln Tyr Gly 
        355                 360                 365             


Asn Ala Ile Ser Leu Phe Gly Arg Asp Cys Ser Val Gln Arg Arg His 
    370                 375                 380                 


Gln Lys Ile Ile Glu Glu Ala Pro Ala Thr Ile Ala Thr Pro Ala Val 
385                 390                 395                 400 


Phe Glu His Met Glu Gln Cys Ala Val Lys Leu Ala Lys Met Val Gly 
                405                 410                 415     


Tyr Val Ser Ala Gly Thr Val Glu Tyr Leu Tyr Ser Gln Asp Gly Ser 
            420                 425                 430         


Phe Tyr Phe Leu Glu Leu Asn Pro Arg Leu Gln Val Glu His Pro Cys 
        435                 440                 445             


Thr Glu Met Val Ala Asp Val Asn Leu Pro Ala Ala Gln Leu Gln Ile 
    450                 455                 460                 


Ala Met Gly Ile Pro Leu Tyr Arg Ile Lys Asp Ile Arg Met Met Tyr 
465                 470                 475                 480 


Gly Val Ser Pro Trp Gly Asp Ser Pro Ile Asp Phe Glu Asp Ser Ala 
                485                 490                 495     


His Val Pro Cys Pro Arg Gly His Val Ile Ala Ala Arg Ile Thr Ser 
            500                 505                 510         


Glu Asn Pro Asp Glu Gly Phe Lys Pro Ser Ser Gly Thr Val Gln Glu 
        515                 520                 525             


Leu Asn Phe Arg Ser Asn Lys Asn Val Trp Gly Tyr Phe Ser Val Ala 
    530                 535                 540                 


Ala Ala Gly Gly Leu His Glu Phe Ala Asp Ser Gln Phe Gly His Cys 
545                 550                 555                 560 


Phe Ser Trp Gly Glu Asn Arg Glu Glu Ala Ile Ser Asn Met Val Val 
                565                 570                 575     


Ala Leu Lys Glu Leu Ser Ile Arg Gly Asp Phe Arg Thr Thr Val Glu 
            580                 585                 590         


Tyr Leu Ile Lys Leu Leu Glu Thr Glu Ser Phe Gln Met Asn Arg Ile 
        595                 600                 605             


Asp Thr Gly Trp Leu Asp Arg Leu Ile Ala Glu Lys Val Gln Ala Glu 
    610                 615                 620                 


Arg Pro Asp Thr Met Leu Gly Val Val Cys Gly Ala Leu His Val Ala 
625                 630                 635                 640 


Asp Val Ser Leu Arg Asn Ser Val Ser Asn Phe Leu His Ser Leu Glu 
                645                 650                 655     


Arg Gly Gln Val Leu Pro Ala His Thr Leu Leu Asn Thr Val Asp Val 
            660                 665                 670         


Glu Leu Ile Tyr Glu Gly Val Lys Tyr Val Leu Lys Val Thr Arg Gln 
        675                 680                 685             


Ser Pro Asn Ser Tyr Val Val Ile Met Asn Gly Ser Cys Val Glu Val 
    690                 695                 700                 


Asp Val His Arg Leu Ser Asp Gly Gly Leu Leu Leu Ser Tyr Asp Gly 
705                 710                 715                 720 


Ser Ser Tyr Thr Thr Tyr Met Lys Glu Glu Val Asp Arg Tyr Arg Ile 
                725                 730                 735     


Thr Ile Gly Asn Lys Thr Cys Val Phe Glu Lys Glu Asn Asp Pro Ser 
            740                 745                 750         


Val Met Arg Ser Pro Ser Ala Gly Lys Leu Ile Gln Tyr Ile Val Glu 
        755                 760                 765             


Asp Gly Gly His Val Phe Ala Gly Gln Cys Tyr Ala Glu Ile Glu Val 
    770                 775                 780                 


Met Lys Met Val Met Thr Leu Thr Ala Val Glu Ser Gly Cys Ile His 
785                 790                 795                 800 


Tyr Val Lys Arg Pro Gly Ala Ala Leu Asp Pro Gly Cys Val Leu Ala 
                805                 810                 815     


Lys Met Gln Leu Asp Asn Pro Ser Lys Val Gln Gln Ala Glu Leu His 
            820                 825                 830         


Thr Gly Ser Leu Pro Arg Ile Gln Ser Thr Ala Leu Arg Gly Glu Lys 
        835                 840                 845             


Leu His Arg Val Phe His Tyr Val Leu Asp Asn Leu Val Asn Val Met 
    850                 855                 860                 


Asn Gly Tyr Cys Leu Pro Asp Pro Phe Phe Ser Ser Lys Val Lys Asp 
865                 870                 875                 880 


Trp Val Glu Arg Leu Met Lys Thr Leu Arg Asp Pro Ser Leu Pro Leu 
                885                 890                 895     


Leu Glu Leu Gln Asp Ile Met Thr Ser Val Ser Gly Arg Ile Pro Pro 
            900                 905                 910         


Asn Val Glu Lys Ser Ile Lys Lys Glu Met Ala Gln Tyr Ala Ser Asn 
        915                 920                 925             


Ile Thr Ser Val Leu Cys Gln Phe Pro Ser Gln Gln Ile Ala Asn Ile 
    930                 935                 940                 


Leu Asp Ser His Ala Ala Thr Leu Asn Arg Lys Ser Glu Arg Glu Val 
945                 950                 955                 960 


Phe Phe Met Asn Thr Gln Ser Ile Val Gln Leu Val Gln Arg Tyr Arg 
                965                 970                 975     


Ser Gly Ile Arg Gly His Met Lys Ala Val Val Met Asp Leu Leu Arg 
            980                 985                 990         


Gln Tyr Leu Arg Val Glu Thr Gln  Phe Gln Asn Gly His  Tyr Asp Lys 
        995                 1000                 1005             


Cys Val  Phe Ala Leu Arg Glu  Glu Asn Lys Ser Asp  Met Asn Thr 
    1010                 1015                 1020             


Val Leu  Asn Tyr Ile Phe Ser  His Ala Gln Val Thr  Lys Lys Asn 
    1025                 1030                 1035             


Leu Leu  Val Thr Met Leu Ile  Asp Gln Leu Cys Gly  Arg Asp Pro 
    1040                 1045                 1050             


Thr Leu  Thr Asp Glu Leu Leu  Asn Ile Leu Thr Glu  Leu Thr Gln 
    1055                 1060                 1065             


Leu Ser  Lys Thr Thr Asn Ala  Lys Val Ala Leu Arg  Ala Arg Gln 
    1070                 1075                 1080             


Val Leu  Ile Ala Ser His Leu  Pro Ser Tyr Glu Leu  Arg His Asn 
    1085                 1090                 1095             


Gln Val  Glu Ser Ile Phe Leu  Ser Ala Ile Asp Met  Tyr Gly His 
    1100                 1105                 1110             


Gln Phe  Cys Ile Glu Asn Leu  Gln Lys Leu Ile Leu  Ser Glu Thr 
    1115                 1120                 1125             


Ser Ile  Phe Asp Val Leu Pro  Asn Phe Phe Tyr His  Ser Asn Gln 
    1130                 1135                 1140             


Val Val  Arg Met Ala Ala Leu  Glu Val Tyr Val Arg  Arg Ala Tyr 
    1145                 1150                 1155             


Ile Ala  Tyr Glu Leu Asn Ser  Val Gln His Arg Gln  Leu Lys Asp 
    1160                 1165                 1170             


Asn Thr  Cys Val Val Glu Phe  Gln Phe Met Leu Pro  Thr Ser His 
    1175                 1180                 1185             


Pro Asn  Arg Gly Asn Ile Pro  Thr Leu Asn Arg Met  Ser Phe Ser 
    1190                 1195                 1200             


Ser Asn  Leu Asn His Tyr Gly  Met Thr His Val Ala  Ser Val Ser 
    1205                 1210                 1215             


Asp Val  Leu Leu Asp Asn Ser  Phe Thr Pro Pro Cys  Gln Arg Met 
    1220                 1225                 1230             


Gly Gly  Met Val Ser Phe Arg  Thr Phe Glu Asp Phe  Val Arg Ile 
    1235                 1240                 1245             


Phe Asp  Glu Val Met Gly Cys  Phe Ser Asp Ser Pro  Pro Gln Ser 
    1250                 1255                 1260             


Pro Thr  Phe Pro Glu Ala Gly  His Thr Ser Leu Tyr  Asp Glu Asp 
    1265                 1270                 1275             


Lys Val  Pro Arg Asp Glu Pro  Ile His Ile Leu Asn  Val Ala Ile 
    1280                 1285                 1290             


Lys Thr  Asp Cys Asp Ile Glu  Asp Asp Arg Leu Ala  Ala Met Phe 
    1295                 1300                 1305             


Arg Glu  Phe Thr Gln Gln Asn  Lys Ala Thr Leu Val  Asp His Gly 
    1310                 1315                 1320             


Ile Arg  Arg Leu Thr Phe Leu  Val Ala Gln Lys Asp  Phe Arg Lys 
    1325                 1330                 1335             


Gln Val  Asn Tyr Glu Val Asp  Arg Arg Phe His Arg  Glu Phe Pro 
    1340                 1345                 1350             


Lys Phe  Phe Thr Phe Arg Ala  Arg Asp Lys Phe Glu  Glu Asp Arg 
    1355                 1360                 1365             


Ile Tyr  Arg His Leu Glu Pro  Ala Leu Ala Phe Gln  Leu Glu Leu 
    1370                 1375                 1380             


Asn Arg  Met Arg Asn Phe Asp  Leu Thr Ala Ile Pro  Cys Ala Asn 
    1385                 1390                 1395             


His Lys  Met His Leu Tyr Leu  Gly Ala Ala Lys Val  Glu Val Gly 
    1400                 1405                 1410             


Thr Glu  Val Thr Asp Tyr Arg  Phe Phe Val Arg Ala  Ile Ile Arg 
    1415                 1420                 1425             


His Ser  Asp Leu Val Thr Lys  Glu Ala Ser Phe Glu  Tyr Leu Gln 
    1430                 1435                 1440             


Asn Glu  Gly Glu Arg Leu Leu  Leu Glu Ala Met Asp  Glu Leu Glu 
    1445                 1450                 1455             


Val Ala  Phe Asn Asn Thr Asn  Val Arg Thr Asp Cys  Asn His Ile 
    1460                 1465                 1470             


Phe Leu  Asn Phe Val Pro Thr  Val Ile Met Asp Pro  Ser Lys Ile 
    1475                 1480                 1485             


Glu Glu  Ser Val Arg Ser Met  Val Met Arg Tyr Gly  Ser Arg Leu 
    1490                 1495                 1500             


Trp Lys  Leu Arg Val Leu Gln  Ala Glu Leu Lys Ile  Asn Ile Arg 
    1505                 1510                 1515             


Leu Thr  Pro Thr Gly Lys Ala  Ile Pro Ile Arg Leu  Phe Leu Thr 
    1520                 1525                 1530             


Asn Glu  Ser Gly Tyr Tyr Leu  Asp Ile Ser Leu Tyr  Lys Glu Val 
    1535                 1540                 1545             


Thr Asp  Ser Arg Thr Ala Gln  Ile Met Phe Gln Ala  Tyr Gly Asp 
    1550                 1555                 1560             


Lys Gln  Gly Pro Leu His Gly  Met Leu Ile Asn Thr  Pro Tyr Val 
    1565                 1570                 1575             


Thr Lys  Asp Leu Leu Gln Ser  Lys Arg Phe Gln Ala  Gln Ser Leu 
    1580                 1585                 1590             


Gly Thr  Thr Tyr Ile Tyr Asp  Ile Pro Glu Met Phe  Arg Gln Ser 
    1595                 1600                 1605             


Leu Ile  Lys Leu Trp Glu Ser  Met Ser Thr Gln Ala  Phe Leu Pro 
    1610                 1615                 1620             


Ser Pro  Pro Leu Pro Ser Asp  Met Leu Thr Tyr Thr  Glu Leu Val 
    1625                 1630                 1635             


Leu Asp  Asp Gln Gly Gln Leu  Val His Met Asn Arg  Leu Pro Gly 
    1640                 1645                 1650             


Gly Asn  Glu Ile Gly Met Val  Ala Trp Lys Met Thr  Phe Lys Ser 
    1655                 1660                 1665             


Pro Glu  Tyr Pro Glu Gly Arg  Asp Ile Ile Val Ile  Gly Asn Asp 
    1670                 1675                 1680             


Ile Thr  Tyr Arg Ile Gly Ser  Phe Gly Pro Gln Glu  Asp Leu Leu 
    1685                 1690                 1695             


Phe Leu  Arg Ala Ser Glu Leu  Ala Arg Ala Glu Gly  Ile Pro Arg 
    1700                 1705                 1710             


Ile Tyr  Val Ser Ala Asn Ser  Gly Ala Arg Ile Gly  Leu Ala Glu 
    1715                 1720                 1725             


Glu Ile  Arg His Met Phe His  Val Ala Trp Val Asp  Pro Glu Asp 
    1730                 1735                 1740             


Pro Tyr  Lys Gly Tyr Arg Tyr  Leu Tyr Leu Thr Pro  Gln Asp Tyr 
    1745                 1750                 1755             


Lys Arg  Val Ser Ala Leu Asn  Ser Val His Cys Glu  His Val Glu 
    1760                 1765                 1770             


Asp Glu  Gly Glu Ser Arg Tyr  Lys Ile Thr Asp Ile  Ile Gly Lys 
    1775                 1780                 1785             


Glu Glu  Gly Ile Gly Pro Glu  Asn Leu Arg Gly Ser  Gly Met Ile 
    1790                 1795                 1800             


Ala Gly  Glu Ser Ser Leu Ala  Tyr Asn Glu Ile Ile  Thr Ile Ser 
    1805                 1810                 1815             


Leu Val  Thr Cys Arg Ala Ile  Gly Ile Gly Ala Tyr  Leu Val Arg 
    1820                 1825                 1830             


Leu Gly  Gln Arg Thr Ile Gln  Val Glu Asn Ser His  Leu Ile Leu 
    1835                 1840                 1845             


Thr Gly  Ala Gly Ala Leu Asn  Lys Val Leu Gly Arg  Glu Val Tyr 
    1850                 1855                 1860             


Thr Ser  Asn Asn Gln Leu Gly  Gly Ile Gln Ile Met  His Asn Asn 
    1865                 1870                 1875             


Gly Val  Thr His Cys Thr Val  Cys Asp Asp Phe Glu  Gly Val Phe 
    1880                 1885                 1890             


Thr Val  Leu His Trp Leu Ser  Tyr Met Pro Lys Ser  Val His Ser 
    1895                 1900                 1905             


Ser Val  Pro Leu Leu Asn Ser  Lys Asp Pro Ile Asp  Arg Ile Ile 
    1910                 1915                 1920             


Glu Phe  Val Pro Thr Lys Thr  Pro Tyr Asp Pro Arg  Trp Met Leu 
    1925                 1930                 1935             


Ala Gly  Arg Pro His Pro Thr  Gln Lys Gly Gln Trp  Leu Ser Gly 
    1940                 1945                 1950             


Phe Phe  Asp Tyr Gly Ser Phe  Ser Glu Ile Met Gln  Pro Trp Ala 
    1955                 1960                 1965             


Gln Thr  Val Val Val Gly Arg  Ala Arg Leu Gly Gly  Ile Pro Val 
    1970                 1975                 1980             


Gly Val  Val Ala Val Glu Thr  Arg Thr Val Glu Leu  Ser Ile Pro 
    1985                 1990                 1995             


Ala Asp  Pro Ala Asn Leu Asp  Ser Glu Ala Lys Ile  Ile Gln Gln 
    2000                 2005                 2010             


Ala Gly  Gln Val Trp Phe Pro  Asp Ser Ala Phe Lys  Thr Tyr Gln 
    2015                 2020                 2025             


Ala Ile  Lys Asp Phe Asn Arg  Glu Gly Leu Pro Leu  Met Val Phe 
    2030                 2035                 2040             


Ala Asn  Trp Arg Gly Phe Ser  Gly Gly Met Lys Asp  Met Tyr Asp 
    2045                 2050                 2055             


Gln Val  Leu Lys Phe Gly Ala  Tyr Ile Val Asp Gly  Leu Arg Glu 
    2060                 2065                 2070             


Cys Cys  Gln Pro Val Leu Val  Tyr Ile Pro Pro Gln  Ala Glu Leu 
    2075                 2080                 2085             


Arg Gly  Gly Ser Trp Val Val  Ile Asp Ser Ser Ile  Asn Pro Arg 
    2090                 2095                 2100             


His Met  Glu Met Tyr Ala Asp  Arg Glu Ser Arg Gly  Ser Val Leu 
    2105                 2110                 2115             


Glu Pro  Glu Gly Thr Val Glu  Ile Lys Phe Arg Arg  Lys Asp Leu 
    2120                 2125                 2130             


Val Lys  Thr Met Arg Arg Val  Asp Pro Val Tyr Ile  His Leu Ala 
    2135                 2140                 2145             


Glu Arg  Leu Gly Thr Pro Glu  Leu Ser Thr Ala Glu  Arg Lys Glu 
    2150                 2155                 2160             


Leu Glu  Asn Lys Leu Lys Glu  Arg Glu Glu Phe Leu  Ile Pro Ile 
    2165                 2170                 2175             


Tyr His  Gln Val Ala Val Gln  Phe Ala Asp Leu His  Asp Thr Pro 
    2180                 2185                 2190             


Gly Arg  Met Gln Glu Lys Gly  Val Ile Ser Asp Ile  Leu Asp Trp 
    2195                 2200                 2205             


Lys Thr  Ser Arg Thr Phe Phe  Tyr Trp Arg Leu Arg  Arg Leu Leu 
    2210                 2215                 2220             


Leu Glu  Asp Leu Val Lys Lys  Lys Ile His Asn Ala  Asn Pro Glu 
    2225                 2230                 2235             


Leu Thr  Asp Gly Gln Ile Gln  Ala Met Leu Arg Arg  Trp Phe Val 
    2240                 2245                 2250             


Glu Val  Glu Gly Thr Val Lys  Ala Tyr Val Trp Asp  Asn Asn Lys 
    2255                 2260                 2265             


Asp Leu  Ala Glu Trp Leu Glu  Lys Gln Leu Thr Glu  Glu Asp Gly 
    2270                 2275                 2280             


Val His  Ser Val Ile Glu Glu  Asn Ile Lys Cys Ile  Ser Arg Asp 
    2285                 2290                 2295             


Tyr Val  Leu Lys Gln Ile Arg  Ser Leu Val Gln Ala  Asn Pro Glu 
    2300                 2305                 2310             


Val Ala  Met Asp Ser Ile Ile  His Met Thr Gln His  Ile Ser Pro 
    2315                 2320                 2325             


Thr Gln  Arg Ala Glu Val Ile  Arg Ile Leu Ser Thr  Met Asp Ser 
    2330                 2335                 2340             


Pro Ser  Thr 
    2345     


<210>  61
<211>  329
<212>  PRT
<213>  Streptomyces sp.

<400>  61

Met Thr Asp Val Arg Phe Arg Ile Ile Gly Thr Gly Ala Tyr Val Pro 
1               5                   10                  15      


Glu Arg Ile Val Ser Asn Asp Glu Val Gly Ala Pro Ala Gly Val Asp 
            20                  25                  30          


Asp Asp Trp Ile Thr Arg Lys Thr Gly Ile Arg Gln Arg Arg Trp Ala 
        35                  40                  45              


Ala Asp Asp Gln Ala Thr Ser Asp Leu Ala Thr Ala Ala Gly Arg Ala 
    50                  55                  60                  


Ala Leu Lys Ala Ala Gly Ile Thr Pro Glu Gln Leu Thr Val Ile Ala 
65                  70                  75                  80  


Val Ala Thr Ser Thr Pro Asp Arg Pro Gln Pro Pro Thr Ala Ala Tyr 
                85                  90                  95      


Val Gln His His Leu Gly Ala Thr Gly Thr Ala Ala Phe Asp Val Asn 
            100                 105                 110         


Ala Val Cys Ser Gly Thr Val Phe Ala Leu Ser Ser Val Ala Gly Thr 
        115                 120                 125             


Leu Val Tyr Arg Gly Gly Tyr Ala Leu Val Ile Gly Ala Asp Leu Tyr 
    130                 135                 140                 


Ser Arg Ile Leu Asn Pro Ala Asp Arg Lys Thr Val Val Leu Phe Gly 
145                 150                 155                 160 


Asp Gly Ala Gly Ala Met Val Leu Gly Pro Thr Ser Thr Gly Thr Gly 
                165                 170                 175     


Pro Ile Val Arg Arg Val Ala Leu His Thr Phe Gly Gly Leu Thr Asp 
            180                 185                 190         


Leu Ile Arg Val Pro Ala Gly Gly Ser Arg Gln Pro Leu Asp Thr Asp 
        195                 200                 205             


Gly Leu Asp Ala Gly Leu Gln Tyr Phe Ala Met Asp Gly Arg Glu Val 
    210                 215                 220                 


Arg Arg Phe Val Thr Glu His Leu Pro Gln Leu Ile Lys Gly Phe Leu 
225                 230                 235                 240 


His Glu Ala Gly Val Asp Ala Ala Asp Ile Ser His Phe Val Pro His 
                245                 250                 255     


Gln Ala Asn Gly Val Met Leu Asp Glu Val Phe Gly Glu Leu His Leu 
            260                 265                 270         


Pro Arg Ala Thr Met His Arg Thr Val Glu Thr Tyr Gly Asn Thr Gly 
        275                 280                 285             


Ala Ala Ser Ile Pro Ile Thr Met Asp Ala Ala Val Arg Ala Gly Ser 
    290                 295                 300                 


Phe Arg Pro Gly Glu Leu Val Leu Leu Ala Gly Phe Gly Gly Gly Met 
305                 310                 315                 320 


Ala Ala Ser Phe Ala Leu Ile Glu Trp 
                325                 


<210>  62
<211>  323
<212>  PRT
<213>  Escherichia coli

<400>  62

Met Met Ala Asn Arg Met Ile Leu Asn Glu Thr Ala Trp Phe Gly Arg 
1               5                   10                  15      


Gly Ala Val Gly Ala Leu Thr Asp Glu Val Lys Arg Arg Gly Tyr Gln 
            20                  25                  30          


Lys Ala Leu Ile Val Thr Asp Lys Thr Leu Val Gln Cys Gly Val Val 
        35                  40                  45              


Ala Lys Val Thr Asp Lys Met Asp Ala Ala Gly Leu Ala Trp Ala Ile 
    50                  55                  60                  


Tyr Asp Gly Val Val Pro Asn Pro Thr Ile Thr Val Val Lys Glu Gly 
65                  70                  75                  80  


Leu Gly Val Phe Gln Asn Ser Gly Ala Asp Tyr Leu Ile Ala Ile Gly 
                85                  90                  95      


Gly Gly Ser Pro Gln Asp Thr Cys Lys Ala Ile Gly Ile Ile Ser Asn 
            100                 105                 110         


Asn Pro Glu Phe Ala Asp Val Arg Ser Leu Glu Gly Leu Ser Pro Thr 
        115                 120                 125             


Asn Lys Pro Ser Val Pro Ile Leu Ala Ile Pro Thr Thr Ala Gly Thr 
    130                 135                 140                 


Ala Ala Glu Val Thr Ile Asn Tyr Val Ile Thr Asp Glu Glu Lys Arg 
145                 150                 155                 160 


Arg Lys Phe Val Cys Val Asp Pro His Asp Ile Pro Gln Val Ala Phe 
                165                 170                 175     


Ile Asp Ala Asp Met Met Asp Gly Met Pro Pro Ala Leu Lys Ala Ala 
            180                 185                 190         


Thr Gly Val Asp Ala Leu Thr His Ala Ile Glu Gly Tyr Ile Thr Arg 
        195                 200                 205             


Gly Ala Trp Ala Leu Thr Asp Ala Leu His Ile Lys Ala Ile Glu Ile 
    210                 215                 220                 


Ile Ala Gly Ala Leu Arg Gly Ser Val Ala Gly Asp Lys Asp Ala Gly 
225                 230                 235                 240 


Glu Glu Met Ala Leu Gly Gln Tyr Val Ala Gly Met Gly Phe Ser Asn 
                245                 250                 255     


Val Gly Leu Gly Leu Val His Gly Met Ala His Pro Leu Gly Ala Phe 
            260                 265                 270         


Tyr Asn Thr Pro His Gly Val Ala Asn Ala Ile Leu Leu Pro His Val 
        275                 280                 285             


Met Arg Tyr Asn Ala Asp Phe Thr Gly Glu Lys Tyr Val Cys Thr Gly 
    290                 295                 300                 


Gly Asn Pro Arg Glu Ala Thr Leu Glu Asp Ile Val Glu Leu Tyr His 
305                 310                 315                 320 


Thr Ala Trp 
            


<210>  63
<211>  858
<212>  PRT
<213>  Clostridium acetobutylicum

<400>  63

Met Lys Val Thr Asn Gln Lys Glu Leu Lys Gln Lys Leu Asn Glu Leu 
1               5                   10                  15      


Arg Glu Ala Gln Lys Lys Phe Ala Thr Tyr Thr Gln Glu Gln Val Asp 
            20                  25                  30          


Lys Ile Phe Lys Gln Cys Ala Ile Ala Ala Ala Lys Glu Arg Ile Asn 
        35                  40                  45              


Leu Ala Lys Leu Ala Val Glu Glu Thr Gly Ile Gly Leu Val Glu Asp 
    50                  55                  60                  


Lys Ile Ile Lys Asn His Phe Ala Ala Glu Tyr Ile Tyr Asn Lys Tyr 
65                  70                  75                  80  


Lys Asn Glu Lys Thr Cys Gly Ile Ile Asp His Asp Asp Ser Leu Gly 
                85                  90                  95      


Ile Thr Lys Val Ala Glu Pro Ile Gly Ile Val Ala Ala Ile Val Pro 
            100                 105                 110         


Thr Thr Asn Pro Thr Ser Thr Ala Ile Phe Lys Ser Leu Ile Ser Leu 
        115                 120                 125             


Lys Thr Arg Asn Ala Ile Phe Phe Ser Pro His Pro Arg Ala Lys Lys 
    130                 135                 140                 


Ser Thr Ile Ala Ala Ala Lys Leu Ile Leu Asp Ala Ala Val Lys Ala 
145                 150                 155                 160 


Gly Ala Pro Lys Asn Ile Ile Gly Trp Ile Asp Glu Pro Ser Ile Glu 
                165                 170                 175     


Leu Ser Gln Asp Leu Met Ser Glu Ala Asp Ile Ile Leu Ala Thr Gly 
            180                 185                 190         


Gly Pro Ser Met Val Lys Ala Ala Tyr Ser Ser Gly Lys Pro Ala Ile 
        195                 200                 205             


Gly Val Gly Ala Gly Asn Thr Pro Ala Ile Ile Asp Glu Ser Ala Asp 
    210                 215                 220                 


Ile Asp Met Ala Val Ser Ser Ile Ile Leu Ser Lys Thr Tyr Asp Asn 
225                 230                 235                 240 


Gly Val Ile Cys Ala Ser Glu Gln Ser Ile Leu Val Met Asn Ser Ile 
                245                 250                 255     


Tyr Glu Lys Val Lys Glu Glu Phe Val Lys Arg Gly Ser Tyr Ile Leu 
            260                 265                 270         


Asn Gln Asn Glu Ile Ala Lys Ile Lys Glu Thr Met Phe Lys Asn Gly 
        275                 280                 285             


Ala Ile Asn Ala Asp Ile Val Gly Lys Ser Ala Tyr Ile Ile Ala Lys 
    290                 295                 300                 


Met Ala Gly Ile Glu Val Pro Gln Thr Thr Lys Ile Leu Ile Gly Glu 
305                 310                 315                 320 


Val Gln Ser Val Glu Lys Ser Glu Leu Phe Ser His Glu Lys Leu Ser 
                325                 330                 335     


Pro Val Leu Ala Met Tyr Lys Val Lys Asp Phe Asp Glu Ala Leu Lys 
            340                 345                 350         


Lys Ala Gln Arg Leu Ile Glu Leu Gly Gly Ser Gly His Thr Ser Ser 
        355                 360                 365             


Leu Tyr Ile Asp Ser Gln Asn Asn Lys Asp Lys Val Lys Glu Phe Gly 
    370                 375                 380                 


Leu Ala Met Lys Thr Ser Arg Thr Phe Ile Asn Met Pro Ser Ser Gln 
385                 390                 395                 400 


Gly Ala Ser Gly Asp Leu Tyr Asn Phe Ala Ile Ala Pro Ser Phe Thr 
                405                 410                 415     


Leu Gly Cys Gly Thr Trp Gly Gly Asn Ser Val Ser Gln Asn Val Glu 
            420                 425                 430         


Pro Lys His Leu Leu Asn Ile Lys Ser Val Ala Glu Arg Arg Glu Asn 
        435                 440                 445             


Met Leu Trp Phe Lys Val Pro Gln Lys Ile Tyr Phe Lys Tyr Gly Cys 
    450                 455                 460                 


Leu Arg Phe Ala Leu Lys Glu Leu Lys Asp Met Asn Lys Lys Arg Ala 
465                 470                 475                 480 


Phe Ile Val Thr Asp Lys Asp Leu Phe Lys Leu Gly Tyr Val Asn Lys 
                485                 490                 495     


Ile Thr Lys Val Leu Asp Glu Ile Asp Ile Lys Tyr Ser Ile Phe Thr 
            500                 505                 510         


Asp Ile Lys Ser Asp Pro Thr Ile Asp Ser Val Lys Lys Gly Ala Lys 
        515                 520                 525             


Glu Met Leu Asn Phe Glu Pro Asp Thr Ile Ile Ser Ile Gly Gly Gly 
    530                 535                 540                 


Ser Pro Met Asp Ala Ala Lys Val Met His Leu Leu Tyr Glu Tyr Pro 
545                 550                 555                 560 


Glu Ala Glu Ile Glu Asn Leu Ala Ile Asn Phe Met Asp Ile Arg Lys 
                565                 570                 575     


Arg Ile Cys Asn Phe Pro Lys Leu Gly Thr Lys Ala Ile Ser Val Ala 
            580                 585                 590         


Ile Pro Thr Thr Ala Gly Thr Gly Ser Glu Ala Thr Pro Phe Ala Val 
        595                 600                 605             


Ile Thr Asn Asp Glu Thr Gly Met Lys Tyr Pro Leu Thr Ser Tyr Glu 
    610                 615                 620                 


Leu Thr Pro Asn Met Ala Ile Ile Asp Thr Glu Leu Met Leu Asn Met 
625                 630                 635                 640 


Pro Arg Lys Leu Thr Ala Ala Thr Gly Ile Asp Ala Leu Val His Ala 
                645                 650                 655     


Ile Glu Ala Tyr Val Ser Val Met Ala Thr Asp Tyr Thr Asp Glu Leu 
            660                 665                 670         


Ala Leu Arg Ala Ile Lys Met Ile Phe Lys Tyr Leu Pro Arg Ala Tyr 
        675                 680                 685             


Lys Asn Gly Thr Asn Asp Ile Glu Ala Arg Glu Lys Met Ala His Ala 
    690                 695                 700                 


Ser Asn Ile Ala Gly Met Ala Phe Ala Asn Ala Phe Leu Gly Val Cys 
705                 710                 715                 720 


His Ser Met Ala His Lys Leu Gly Ala Met His His Val Pro His Gly 
                725                 730                 735     


Ile Ala Cys Ala Val Leu Ile Glu Glu Val Ile Lys Tyr Asn Ala Thr 
            740                 745                 750         


Asp Cys Pro Thr Lys Gln Thr Ala Phe Pro Gln Tyr Lys Ser Pro Asn 
        755                 760                 765             


Ala Lys Arg Lys Tyr Ala Glu Ile Ala Glu Tyr Leu Asn Leu Lys Gly 
    770                 775                 780                 


Thr Ser Asp Thr Glu Lys Val Thr Ala Leu Ile Glu Ala Ile Ser Lys 
785                 790                 795                 800 


Leu Lys Ile Asp Leu Ser Ile Pro Gln Asn Ile Ser Ala Ala Gly Ile 
                805                 810                 815     


Asn Lys Lys Asp Phe Tyr Asn Thr Leu Asp Lys Met Ser Glu Leu Ala 
            820                 825                 830         


Phe Asp Asp Gln Cys Thr Thr Ala Asn Pro Arg Tyr Pro Leu Ile Ser 
        835                 840                 845             


Glu Leu Lys Asp Ile Tyr Ile Lys Ser Phe 
    850                 855             


<210>  64
<211>  514
<212>  PRT
<213>  Euglena gracilis

<400>  64

Met Asn Asp Phe Tyr Ala Gly Lys Gly Val Phe Leu Thr Gly Val Thr 
1               5                   10                  15      


Gly Phe Val Gly Lys Met Val Val Glu Lys Ile Leu Arg Ser Leu Pro 
            20                  25                  30          


Thr Val Gly Arg Leu Tyr Val Leu Val Arg Pro Lys Ala Gly Thr Asp 
        35                  40                  45              


Pro His Gln Arg Leu His Ser Glu Val Trp Ser Ser Ala Gly Phe Asp 
    50                  55                  60                  


Val Val Arg Glu Lys Val Gly Gly Pro Ala Ala Phe Asp Ala Leu Ile 
65                  70                  75                  80  


Arg Glu Lys Val Val Pro Val Pro Gly Asp Met Val Lys Asp Arg Phe 
                85                  90                  95      


Gly Leu Asp Asp Ala Ala Tyr Arg Ser Leu Ala Ala Asn Val Asn Val 
            100                 105                 110         


Ile Ile His Met Ala Ala Thr Ile Asp Phe Thr Glu Arg Leu Asp Val 
        115                 120                 125             


Ala Val Ser Leu Asn Val Leu Gly Thr Val Arg Val Leu Thr Leu Ala 
    130                 135                 140                 


Arg Arg Ala Arg Glu Leu Gly Ala Leu His Ser Val Val His Val Ser 
145                 150                 155                 160 


Thr Cys Tyr Val Asn Ser Asn Gln Pro Pro Gly Ala Arg Leu Arg Glu 
                165                 170                 175     


Gln Leu Tyr Pro Leu Pro Phe Asp Pro Arg Glu Met Cys Thr Arg Ile 
            180                 185                 190         


Leu Asp Met Ser Pro Arg Glu Ile Asp Leu Phe Gly Pro Gln Leu Leu 
        195                 200                 205             


Lys Gln Tyr Gly Phe Pro Asn Thr Tyr Thr Phe Thr Lys Cys Met Ala 
    210                 215                 220                 


Glu Gln Leu Gly Ala Gln Ile Ala His Asp Leu Pro Phe Ala Ile Phe 
225                 230                 235                 240 


Arg Pro Ala Ile Ile Gly Ala Ala Leu Ser Glu Pro Phe Pro Gly Trp 
                245                 250                 255     


Cys Asp Ser Ala Ser Ala Cys Gly Ala Val Phe Leu Ala Val Gly Leu 
            260                 265                 270         


Gly Val Leu Gln Glu Leu Gln Gly Asn Ala Ser Ser Val Cys Asp Leu 
        275                 280                 285             


Ile Pro Val Asp His Val Val Asn Met Leu Leu Val Thr Ala Ala Tyr 
    290                 295                 300                 


Thr Ala Ser Ala Pro Pro Ala Asp Pro Ser Pro Ser Ser Leu Ala Leu 
305                 310                 315                 320 


Ser Pro Pro Gln Leu Pro Leu Ala Thr Leu Pro Pro Gly Thr Val Ala 
                325                 330                 335     


Asp Val Pro Ile Tyr His Cys Gly Thr Ser Ala Gly Pro Asn Ala Val 
            340                 345                 350         


Asn Trp Gly Arg Ile Lys Val Ser Leu Val Glu Tyr Trp Asn Ala His 
        355                 360                 365             


Pro Ile Ala Lys Thr Lys Ala Ala Ile Ala Leu Leu Pro Val Trp Arg 
    370                 375                 380                 


Phe Glu Leu Ser Phe Leu Leu Lys Arg Arg Leu Pro Ala Thr Ala Leu 
385                 390                 395                 400 


Ser Leu Val Ala Ser Leu Pro Gly Ala Ser Ala Ala Val Arg Arg Gln 
                405                 410                 415     


Ala Glu Gln Thr Glu Arg Leu Val Gly Lys Met Arg Lys Leu Val Asp 
            420                 425                 430         


Thr Phe Gln Ser Phe Val Phe Trp Ala Trp Tyr Phe Gln Thr Glu Ser 
        435                 440                 445             


Ser Ala Arg Leu Leu Ala Ser Leu Cys Pro Glu Asp Arg Glu Thr Phe 
    450                 455                 460                 


Asn Trp Asp Pro Arg Arg Ile Gly Trp Arg Ala Trp Val Glu Asn Tyr 
465                 470                 475                 480 


Cys Tyr Gly Leu Val Arg Tyr Val Leu Lys Gln Pro Ile Gly Asp Arg 
                485                 490                 495     


Pro Pro Val Ala Ala Glu Glu Leu Ala Ser Asn Arg Phe Leu Arg Ala 
            500                 505                 510         


Met Leu 
        


<210>  65
<211>  383
<212>  PRT
<213>  Escherichia coli

<400>  65

Met Ala Ala Ser Thr Phe Phe Ile Pro Ser Val Asn Val Ile Gly Ala 
1               5                   10                  15      


Asp Ser Leu Thr Asp Ala Met Asn Met Met Ala Asp Tyr Gly Phe Thr 
            20                  25                  30          


Arg Thr Leu Ile Val Thr Asp Asn Met Leu Thr Lys Leu Gly Met Ala 
        35                  40                  45              


Gly Asp Val Gln Lys Ala Leu Glu Glu Arg Asn Ile Phe Ser Val Ile 
    50                  55                  60                  


Tyr Asp Gly Thr Gln Pro Asn Pro Thr Thr Glu Asn Val Ala Ala Gly 
65                  70                  75                  80  


Leu Lys Leu Leu Lys Glu Asn Asn Cys Asp Ser Val Ile Ser Leu Gly 
                85                  90                  95      


Gly Gly Ser Pro His Asp Cys Ala Lys Gly Ile Ala Leu Val Ala Ala 
            100                 105                 110         


Asn Gly Gly Asp Ile Arg Asp Tyr Glu Gly Val Asp Arg Ser Ala Lys 
        115                 120                 125             


Pro Gln Leu Pro Met Ile Ala Ile Asn Thr Thr Ala Gly Thr Ala Ser 
    130                 135                 140                 


Glu Met Thr Arg Phe Cys Ile Ile Thr Asp Glu Ala Arg His Ile Lys 
145                 150                 155                 160 


Met Ala Ile Val Asp Lys His Val Thr Pro Leu Leu Ser Val Asn Asp 
                165                 170                 175     


Ser Ser Leu Met Ile Gly Met Pro Lys Ser Leu Thr Ala Ala Thr Gly 
            180                 185                 190         


Met Asp Ala Leu Thr His Ala Ile Glu Ala Tyr Val Ser Ile Ala Ala 
        195                 200                 205             


Thr Pro Ile Thr Asp Ala Cys Ala Leu Lys Ala Val Thr Met Ile Ala 
    210                 215                 220                 


Glu Asn Leu Pro Leu Ala Val Glu Asp Gly Ser Asn Ala Lys Ala Arg 
225                 230                 235                 240 


Glu Ala Met Ala Tyr Ala Gln Phe Leu Ala Gly Met Ala Phe Asn Asn 
                245                 250                 255     


Ala Ser Leu Gly Tyr Val His Ala Met Ala His Gln Leu Gly Gly Phe 
            260                 265                 270         


Tyr Asn Leu Pro His Gly Val Cys Asn Ala Val Leu Leu Pro His Val 
        275                 280                 285             


Gln Val Phe Asn Ser Lys Val Ala Ala Ala Arg Leu Arg Asp Cys Ala 
    290                 295                 300                 


Ala Ala Met Gly Val Asn Val Thr Gly Lys Asn Asp Ala Glu Gly Ala 
305                 310                 315                 320 


Glu Ala Cys Ile Asn Ala Ile Arg Glu Leu Ala Lys Lys Val Asp Ile 
                325                 330                 335     


Pro Ala Gly Leu Arg Asp Leu Asn Val Lys Glu Glu Asp Phe Ala Val 
            340                 345                 350         


Leu Ala Thr Asn Ala Leu Lys Asp Ala Cys Gly Phe Thr Asn Pro Ile 
        355                 360                 365             


Gln Ala Thr His Glu Glu Ile Val Ala Ile Tyr Arg Ala Ala Met 
    370                 375                 380             


<210>  66
<211>  60
<212>  DNA
<213>  Artificial

<220>
<223>  PCR primer ADH1crelox fw

<400>  66
atgtctatcc cagaaactca aaaaggtgtt atcttctacg ccagctgaag cttcgtacgc     60


<210>  67
<211>  62
<212>  DNA
<213>  Artificial

<220>
<223>  PCR primer ADH1crelox rev

<400>  67
ttatttagaa gtgtcaacaa cgtatctacc aacgatttga gcataggcca ctagtggatc     60

tg                                                                    62


<210>  68
<211>  61
<212>  DNA
<213>  Artificial

<220>
<223>  PCR primer FPS1crelox fw

<400>  68
atgagtaatc ctcaaaaagc tctaaacgac tttctgtcca gccagctgaa gcttcgtacg     60

c                                                                     61


<210>  69
<211>  62
<212>  DNA
<213>  Artificial

<220>
<223>  PCR primer FPS1crelox rev

<400>  69
tcatgttacc ttcttagcat taccataatg cgaatcttct gcataggcca ctagtggatc     60

tg                                                                    62


<210>  70
<211>  200
<212>  DNA
<213>  Artificial

<220>
<223>  URA3 Marker recycling sequence; MR

<400>  70
catatttaaa gaagacctcg tacgaaagta cgggcttttt tttcgtatat tgcacacacc     60

ggggggatga gaagccccga ccgggttcga caactggcga cacgatgtga cagaccgtga    120

acgcagagag cggcgtcccg ccaggcgagc gaagcgactc aatccccccc tcaccgccat    180

atttaaagaa gacctcgtac                                                200


<210>  71
<211>  2456
<212>  DNA
<213>  Artificial

<220>
<223>  plasmid pMA

<400>  71
ctaaattgta agcgttaata ttttgttaaa attcgcgtta aatttttgtt aaatcagctc     60

attttttaac caataggccg aaatcggcaa aatcccttat aaatcaaaag aatagaccga    120

gatagggttg agtggccgct acagggcgct cccattcgcc attcaggctg cgcaactgtt    180

gggaagggcg tttcggtgcg ggcctcttcg ctattacgcc agctggcgaa agggggatgt    240

gctgcaaggc gattaagttg ggtaacgcca gggttttccc agtcacgacg ttgtaaaacg    300

acggccagtg agcgcgacgt aatacgactc actatagggc gaattggcgg aaggccgtca    360

aggcctaggc gcgccatgag ctctaaagct tcgctcgagc tgcggccgca cggatcctcg    420

aattcccaag cttatctcga gtagcggccg cttggatccc agaattctag gtacctctta    480

attaactggc ctcatgggcc ttccgctcac tgcccgcttt ccagtcggga aacctgtcgt    540

gccagctgca ttaacatggt catagctgtt tccttgcgta ttgggcgctc tccgcttcct    600

cgctcactga ctcgctgcgc tcggtcgttc gggtaaagcc tggggtgcct aatgagcaaa    660

aggccagcaa aaggccagga accgtaaaaa ggccgcgttg ctggcgtttt tccataggct    720

ccgcccccct gacgagcatc acaaaaatcg acgctcaagt cagaggtggc gaaacccgac    780

aggactataa agataccagg cgtttccccc tggaagctcc ctcgtgcgct ctcctgttcc    840

gaccctgccg cttaccggat acctgtccgc ctttctccct tcgggaagcg tggcgctttc    900

tcatagctca cgctgtaggt atctcagttc ggtgtaggtc gttcgctcca agctgggctg    960

tgtgcacgaa ccccccgttc agcccgaccg ctgcgcctta tccggtaact atcgtcttga   1020

gtccaacccg gtaagacacg acttatcgcc actggcagca gccactggta acaggattag   1080

cagagcgagg tatgtaggcg gtgctacaga gttcttgaag tggtggccta actacggcta   1140

cactagaaga acagtatttg gtatctgcgc tctgctgaag ccagttacct tcggaaaaag   1200

agttggtagc tcttgatccg gcaaacaaac caccgctggt agcggtggtt tttttgtttg   1260

caagcagcag attacgcgca gaaaaaaagg atctcaagaa gatcctttga tcttttctac   1320

ggggtctgac gctcagtgga acgaaaactc acgttaaggg attttggtca tgagattatc   1380

aaaaaggatc ttcacctaga tccttttaaa ttaaaaatga agttttaaat caatctaaag   1440

tatatatgag taaacttggt ctgacagtta ccaatgctta atcagtgagg cacctatctc   1500

agcgatctgt ctatttcgtt catccatagt tgcctgactc cccgtcgtgt agataactac   1560

gatacgggag ggcttaccat ctggccccag tgctgcaatg ataccgcgag aaccacgctc   1620

accggctcca gatttatcag caataaacca gccagccgga agggccgagc gcagaagtgg   1680

tcctgcaact ttatccgcct ccatccagtc tattaattgt tgccgggaag ctagagtaag   1740

tagttcgcca gttaatagtt tgcgcaacgt tgttgccatt gctacaggca tcgtggtgtc   1800

acgctcgtcg tttggtatgg cttcattcag ctccggttcc caacgatcaa ggcgagttac   1860

atgatccccc atgttgtgca aaaaagcggt tagctccttc ggtcctccga tcgttgtcag   1920

aagtaagttg gccgcagtgt tatcactcat ggttatggca gcactgcata attctcttac   1980

tgtcatgcca tccgtaagat gcttttctgt gactggtgag tactcaacca agtcattctg   2040

agaatagtgt atgcggcgac cgagttgctc ttgcccggcg tcaatacggg ataataccgc   2100

gccacatagc agaactttaa aagtgctcat cattggaaaa cgttcttcgg ggcgaaaact   2160

ctcaaggatc ttaccgctgt tgagatccag ttcgatgtaa cccactcgtg cacccaactg   2220

atcttcagca tcttttactt tcaccagcgt ttctgggtga gcaaaaacag gaaggcaaaa   2280

tgccgcaaaa aagggaataa gggcgacacg gaaatgttga atactcatac tcttcctttt   2340

tcaatattat tgaagcattt atcagggtta ttgtctcatg agcggataca tatttgaatg   2400

tatttagaaa aataaacaaa taggggttcc gcgcacattt ccccgaaaag tgccac       2456


<210>  72
<211>  519
<212>  DNA
<213>  Artificial

<220>
<223>  CEN/ARS sequence for replication in yeast

<400>  72
ggtccttttc atcacgtgct ataaaaataa ttataattta aattttttaa tataaatata     60

taaattaaaa atagaaagta aaaaaagaaa ttaaagaaaa aatagttttt gttttccgaa    120

gatgtaaaag actctagggg gatcgccaac aaatactacc ttttatcttg ctcttcctgc    180

tctcaggtat taatgccgaa ttgtttcatc ttgtctgtgt agaagaccac acacgaaaat    240

cctgtgattt tacattttac ttatcgttaa tcgaatgtat atctatttaa tctgcttttc    300

ttgtctaata aatatatatg taaagtacgc tttttgttga aattttttaa acctttgttt    360

attttttttt cttcattccg taactcttct accttcttta tttactttct aaaatccaaa    420

tacaaaacat aaaaataaat aaacacagag taaattccca aattattcca tcattaaaag    480

atacgaggcg cgtgtaagtt acaggcaagc gatccgtcc                           519


<210>  73
<211>  816
<212>  DNA
<213>  Saccharomyces cerevisiae

<400>  73
ccatatgatc atgtgtcgtc gcacacatat atatatgcct gtatgtgtca gcactaaagt     60

tgcctggcca tccacgctat atatacacgc ctggcggatc tgctcgagga ttgcctacgc    120

gtgggcttga tccaccaacc aacgctcgcc aaatgaactg gcgctttggt cttctgccat    180

cgtccgtaaa ccccggccaa agagaccgga aagatcggtg aaaacatctt gatcttgctc    240

ccgggaattt tagattcagg taggaaattg attacatcaa tactgttacc ctgaatcata    300

ttcgacgatg tcgtctcaca cggaaatata attcatttct tggttttcca aaaaaatttt    360

catttttttt cacttttttg tttcgtcctc cttttttttt tttttttttt attttttttc    420

ctgtgttcac cttttttttt ttcagttgac atctttctgc attcttttct gtgttttttt    480

tttttttttt cgtttttcca ttgttcgttc gttgcctgtt ttttcgccct attgttctcg    540

agcctaaaaa ttttttcctt tcctgctttc ctttcttcgt tcaaagtttc ctattccatt    600

gttctctttg gtaaactcat tgttgtcgga actcagatat attcaggtca atttactgta    660

cttcaattga cttttttctt gaaatttcaa cttgcctttt caacttgttc ttctttttta    720

atcttattct acactttagt tcccttacct tgttcctaat tattgtctag caaaaagaaa    780

acatacacct atttcattca cacactgcag aaaatg                              816


<210>  74
<211>  951
<212>  DNA
<213>  Artificial

<220>
<223>  synthetic mhpF coding sequence optimized for S.cerevisiae

<400>  74
atgagtaaga gaaaggtcgc tattattggt tccggtaaca ttggtacaga cttgatgata     60

aagattttga gacacggtca acatttggaa atggctgtca tggttggtat cgatcctcaa    120

tctgacggtt tggcaagagc cagaagaatg ggtgtcgcaa ctacacatga aggtgttatt    180

ggtttgatga acatgccaga attcgcagat atagacatcg ttttcgatgc cacatcagct    240

ggtgcacacg ttaaaaacga cgctgcattg agagaagcta agcctgatat tagattgata    300

gacttaaccc cagccgctat tggtccatat tgtgttcctg ttgtcaattt ggaagctaac    360

gttgatcaat tgaacgtaaa catggttaca tgcggtggtc aagcaaccat tcctatggtc    420

gcagccgtat ccagagttgc cagagtccat tacgctgaaa ttatagctag tatagcatcc    480

aaaagtgcag gtccaggtac tagagccaat atagatgaat tcactgaaac cacttctaga    540

gctatcgaag tagttggtgg tgctgcaaag ggtaaagcta tcattgtttt gaaccctgca    600

gaaccacctt taatgatgag agatactgtt tacgtcttat ctgacgaagc ctcacaagat    660

gacatcgaag cttccattaa tgaaatggcc gaagctgtac aagcttatgt tccaggttac    720

agattgaagc aaagagtcca attcgaagta ataccacaag ataagcctgt aaacttacca    780

ggtgttggtc aattctctgg tttgaagacc gctgtttggt tagaagtcga aggtgccgct    840

cactatttgc cagcatacgc cggtaatttg gatattatga cttcttcagc attagcaacc    900

gccgaaaaga tggcacaatc attagcaaga aaggcaggtg aagcagcata a             951


<210>  75
<211>  1521
<212>  DNA
<213>  Artificial

<220>
<223>  synthetic ald-pa coding sequence optimized for S.cerevisiae

<400>  75
atgatatacg ctgcccctgg tactcctggt gctgttgtaa cctttaagcc aagatacggt     60

aactacatcg gtggtgaatt tgtcccacct gtaaagggtc aatacttcac caacacttcc    120

ccagttaacg gtcaacctat agcagaattc ccaagatcta ccgcagaaga tatcgacaag    180

gccttagatg ctgcacatgc cgctgcagac gcttggggta gaacttctgt tcaagaaaga    240

tcaaacatat tgttgaagat agcagataga atcgaacaaa acttggaatt gttagctgtt    300

acagaaacct gggacaatgg taaagctgtc agagaaacct tgaacgcaga tattccatta    360

gccgctgacc actttagata tttcgctggt tgtataagag cacaagaagg ttctgcagcc    420

gaaattaatg attcaacagt tgcttaccat atacacgaac ctttaggtgt tgtcggtcaa    480

ataatccctt ggaacttccc tttgttgatg gctgcatgga aattggcacc agccttagcc    540

gctggtaact gtgtagtttt gaagcctgca gaacaaactc cattaggtat ctgcgttttg    600

ttagaattga tcggtgactt gttaccacct ggtgtcttaa acgtcgtaca aggttttggt    660

agagaagctg gtgaagcttt ggcaacttca aaaagaatag ccaagatcgc tttcaccggt    720

tccactcctg ttggtagtca tattttaaaa tgcgcagccg aaaatatcat tccttctaca    780

gttgaattgg gtggtaaatc accaaacatc tatttcgaag atatcatgca agcagaacca    840

gccttcattg aaaaagctgc agaaggtttg gttttagctt tctttaatca aggtgaagtc    900

tgtacatgcc cttccagagc cttggtacaa gaaagtatct acccagcttt tatggaagaa    960

gtattgaaga aagttagagc tattaaaaga ggtgacccat tggacactga aacaatggtt   1020

ggtgcccaag cttcccaaca acaatacgaa aagatcttga gttacttaga tattgcccaa   1080

caagaaggtg ctgaagtctt aactggtggt tctgtagaaa aattggaagg caatttggct   1140

tcaggttact acatccaacc tacattgttg aaaggtcata acaagatgag agtctttcaa   1200

gaagaaattt tcggtccagt tgtcggtgta actactttta aagatgaagc agaagccttg   1260

gctattgcaa atgacacaga atatggtttg ggtgcaggtt tatggaccag agatatcaac   1320

agagcataca gaatgggtag aggtattaaa gccggtagag tttggacaaa ctgttaccat   1380

ttgtacccag ctcacgccgc tttcggtggt tacaaaaagt ctggtgttgg tagagaaacc   1440

cataagatga tgttggacca ctatcaacaa acaaagaact tattggtatc ctacgacata   1500

gatccattgg gtttcttctg a                                             1521


<210>  76
<211>  1959
<212>  DNA
<213>  Artificial

<220>
<223>  synthetic sequence encoding S. enterica acs optimized for 
       S.cerevisiae

<400>  76
atgtcacaaa ctcacaaaca cgcaatccca gccaacatag ccgatagatg cttgataaac     60

cctgaacaat acgaaacaaa atacaaacaa tctattaatg atccagacac tttttggggt    120

gaacaaggta aaatcttgga ttggatcaca ccataccaaa aggttaagaa tacctcattc    180

gcacctggta acgtatccat taagtggtac gaagatggta cattgaattt ggctgcaaac    240

tgcttggata gacatttgca agaaaatggt gacagaactg ctattatatg ggaaggtgac    300

gacacatcac aatccaagca tatctcttac agagaattac acagagatgt ttgcagattt    360

gccaacactt tgttggattt gggtattaaa aagggtgacg ttgtagctat atacatgcca    420

atggttcctg aagccgctgt agctatgtta gcatgtgcca gaatcggtgc agtacatagt    480

gtcatttttg gtggtttctc tccagaagct gttgcaggta gaatcattga ttcttcatcc    540

agattggtaa taacagcaga cgaaggtgtc agagccggta gatcaatccc attgaagaaa    600

aatgttgatg acgcattgaa aaatcctaac gttacctcag tagaacacgt cattgttttg    660

aagagaactg gttccgatat agactggcaa gaaggtagag atttgtggtg gagagactta    720

attgaaaaag cttccccaga acatcaacct gaagccatga acgctgaaga tccattgttt    780

atattgtaca cttctggttc tacaggtaaa cctaagggtg ttttacacac tacaggtggt    840

tatttggtat acgcagccac cacttttaag tatgtcttcg attaccatcc aggtgacatc    900

tattggtgta ctgcagatgt cggttgggtt acaggtcact cttatttgtt atacggtcca    960

ttagcatgcg gtgccacaac cttgatgttc gaaggtgttc ctaattggcc aactcctgct   1020

agaatgtgtc aagtcgttga taagcatcaa gttaacatct tgtacacagc tccaaccgca   1080

attagagcct tgatggctga aggtgacaag gcaatagaag gtacagacag aagttctttg   1140

agaatattag gttcagttgg tgaaccaatc aatcctgaag cctgggaatg gtactggaaa   1200

aagattggta aagaaaagtg tcctgtagtc gatacatggt ggcaaactga aacaggtggt   1260

tttatgataa ccccattgcc tggtgctatc gaattaaaag caggtagtgc cactagacca   1320

tttttcggtg tccaacctgc attagttgat aatgaaggtc atccacaaga aggtgccacc   1380

gagggtaact tagttattac tgattcttgg cctggtcaag ctagaacatt gtttggtgac   1440

cacgaaagat tcgaacaaac ctacttctca actttcaaaa acatgtactt ctccggtgac   1500

ggtgcaagaa gagatgaaga cggttattac tggattactg gtagagtaga tgatgtttta   1560

aacgttagtg gtcatagatt gggtacagct gaaatcgaat ctgctttagt tgcacatcca   1620

aaaattgccg aagctgcagt tgtaggtatt cctcacgcta taaagggtca agccatctat   1680

gcttacgtta ccttaaatca tggtgaagaa ccatcacctg aattgtatgc tgaagtaaga   1740

aactgggtca gaaaagaaat tggtccattg gcaacacctg atgttttaca ctggacagac   1800

tcattgccaa aaaccagatc cggtaaaatc atgagaagaa tattgagaaa gatagccgct   1860

ggtgacactt ctaatttggg tgacacctct actttggctg accctggtgt agtagaaaag   1920

ccattagaag aaaaacaagc cattgctatg ccaagttag                          1959


<210>  77
<211>  993
<212>  DNA
<213>  Saccharomyces cerevisiae

<400>  77
gatttttata atgacgaaaa aaaaaaaatt ggaaagaaaa agcttaatgc ggtagtttat     60

cacagttaaa ttgctaacgc agtcaggcac cgtgtatgaa atctaacaat gcgctcatcg    120

tcatcctcgg caccgtcacc ctggatgctg taggcatagg cttggttatg ccggtactgc    180

cgggcctctt gcgggatatc gtccattccg acagcatcgc cagtcactat ggcgtgctgc    240

tagcgctata tgcgttgatg caatttctat gcgcacccgt tctcggagca ctgtccgacc    300

gctttggccg ccgcccagtc ctgctcgctt cgctacttgg agccactatc gactacgcga    360

tcatggcgac cacacccgtc ctgtggatcc tctacgccgg acgcatcgtg gccggcatca    420

ccggcgccac aggtgcggtt gctggcgcct atatcgccga catcaccgat ggggaagatc    480

gggctcgcca cttcgggctc atgagcgctt gtttcggcgt gggtatggtg gcaggccccg    540

tggccggggg actgttgggc gccatctcct tgcatgcaac ttcttttctt tttttttctt    600

ttctctctcc cccgttgttg tctcaccata tccgcaatga caaaaaaatg atggaagaca    660

ctaaaggaaa aaattaacga caaagacagc accaacagat gtcgttgttc cagagctgat    720

gaggggtatc tcgaagcaca cgaaactttt tccttccttc attcacgcac actactctct    780

aatgagcaac ggtatacggc cttccttcca gttacttgaa tttgaaataa aaaaaagttt    840

gctgtcttgc tatcaagtat aaatagacct gcaattatta atcttttgtt tcctcgtcat    900

tgttctcgtt ccctttcttc cttgtttctt tttctgcaca atatttcaag ctataccaag    960

catacaatca aggaattcga gctaagcggc cgc                                 993


<210>  78
<211>  375
<212>  PRT
<213>  Saccharomyces cerevisiae


<220>
<221>  MISC_FEATURE
<223>  ADH3

<400>  78

Met Leu Arg Thr Ser Thr Leu Phe Thr Arg Arg Val Gln Pro Ser Leu 
1               5                   10                  15      


Phe Ser Arg Asn Ile Leu Arg Leu Gln Ser Thr Ala Ala Ile Pro Lys 
            20                  25                  30          


Thr Gln Lys Gly Val Ile Phe Tyr Glu Asn Lys Gly Lys Leu His Tyr 
        35                  40                  45              


Lys Asp Ile Pro Val Pro Glu Pro Lys Pro Asn Glu Ile Leu Ile Asn 
    50                  55                  60                  


Val Lys Tyr Ser Gly Val Cys His Thr Asp Leu His Ala Trp His Gly 
65                  70                  75                  80  


Asp Trp Pro Leu Pro Val Lys Leu Pro Leu Val Gly Gly His Glu Gly 
                85                  90                  95      


Ala Gly Val Val Val Lys Leu Gly Ser Asn Val Lys Gly Trp Lys Val 
            100                 105                 110         


Gly Asp Leu Ala Gly Ile Lys Trp Leu Asn Gly Ser Cys Met Thr Cys 
        115                 120                 125             


Glu Phe Cys Glu Ser Gly His Glu Ser Asn Cys Pro Asp Ala Asp Leu 
    130                 135                 140                 


Ser Gly Tyr Thr His Asp Gly Ser Phe Gln Gln Phe Ala Thr Ala Asp 
145                 150                 155                 160 


Ala Ile Gln Ala Ala Lys Ile Gln Gln Gly Thr Asp Leu Ala Glu Val 
                165                 170                 175     


Ala Pro Ile Leu Cys Ala Gly Val Thr Val Tyr Lys Ala Leu Lys Glu 
            180                 185                 190         


Ala Asp Leu Lys Ala Gly Asp Trp Val Ala Ile Ser Gly Ala Ala Gly 
        195                 200                 205             


Gly Leu Gly Ser Leu Ala Val Gln Tyr Ala Thr Ala Met Gly Tyr Arg 
    210                 215                 220                 


Val Leu Gly Ile Asp Ala Gly Glu Glu Lys Glu Lys Leu Phe Lys Lys 
225                 230                 235                 240 


Leu Gly Gly Glu Val Phe Ile Asp Phe Thr Lys Thr Lys Asn Met Val 
                245                 250                 255     


Ser Asp Ile Gln Glu Ala Thr Lys Gly Gly Pro His Gly Val Ile Asn 
            260                 265                 270         


Val Ser Val Ser Glu Ala Ala Ile Ser Leu Ser Thr Glu Tyr Val Arg 
        275                 280                 285             


Pro Cys Gly Thr Val Val Leu Val Gly Leu Pro Ala Asn Ala Tyr Val 
    290                 295                 300                 


Lys Ser Glu Val Phe Ser His Val Val Lys Ser Ile Asn Ile Lys Gly 
305                 310                 315                 320 


Ser Tyr Val Gly Asn Arg Ala Asp Thr Arg Glu Ala Leu Asp Phe Phe 
                325                 330                 335     


Ser Arg Gly Leu Ile Lys Ser Pro Ile Lys Ile Val Gly Leu Ser Glu 
            340                 345                 350         


Leu Pro Lys Val Tyr Asp Leu Met Glu Lys Gly Lys Ile Leu Gly Arg 
        355                 360                 365             


Tyr Val Val Asp Thr Ser Lys 
    370                 375 


<210>  79
<211>  465
<212>  PRT
<213>  Saccharomyces cerevisiae


<220>
<221>  MISC_FEATURE
<223>  ADH4

<400>  79

Met Leu Gly Ile Thr Tyr Ala Val Asn Ser Thr Lys Gln Leu Ile Phe 
1               5                   10                  15      


Cys Cys Leu Lys Tyr Leu Thr Leu Leu Gly Tyr Ile Leu Leu Ser Asn 
            20                  25                  30          


Arg Lys Lys Gly Gln Arg Thr Asn Met Tyr Lys Arg Val Ile Ser Ile 
        35                  40                  45              


Ser Gly Leu Leu Lys Thr Gly Val Lys Arg Phe Ser Ser Val Tyr Cys 
    50                  55                  60                  


Lys Thr Thr Ile Asn Asn Lys Phe Thr Phe Ala Thr Thr Asn Ser Gln 
65                  70                  75                  80  


Ile Arg Lys Met Ser Ser Val Thr Gly Phe Tyr Ile Pro Pro Ile Ser 
                85                  90                  95      


Phe Phe Gly Glu Gly Ala Leu Glu Glu Thr Ala Asp Tyr Ile Lys Asn 
            100                 105                 110         


Lys Asp Tyr Lys Lys Ala Leu Ile Val Thr Asp Pro Gly Ile Ala Ala 
        115                 120                 125             


Ile Gly Leu Ser Gly Arg Val Gln Lys Met Leu Glu Glu Arg Asp Leu 
    130                 135                 140                 


Asn Val Ala Ile Tyr Asp Lys Thr Gln Pro Asn Pro Asn Ile Ala Asn 
145                 150                 155                 160 


Val Thr Ala Gly Leu Lys Val Leu Lys Glu Gln Asn Ser Glu Ile Val 
                165                 170                 175     


Val Ser Ile Gly Gly Gly Ser Ala His Asp Asn Ala Lys Ala Ile Ala 
            180                 185                 190         


Leu Leu Ala Thr Asn Gly Gly Glu Ile Gly Asp Tyr Glu Gly Val Asn 
        195                 200                 205             


Gln Ser Lys Lys Ala Ala Leu Pro Leu Phe Ala Ile Asn Thr Thr Ala 
    210                 215                 220                 


Gly Thr Ala Ser Glu Met Thr Arg Phe Thr Ile Ile Ser Asn Glu Glu 
225                 230                 235                 240 


Lys Lys Ile Lys Met Ala Ile Ile Asp Asn Asn Val Thr Pro Ala Val 
                245                 250                 255     


Ala Val Asn Asp Pro Ser Thr Met Phe Gly Leu Pro Pro Ala Leu Thr 
            260                 265                 270         


Ala Ala Thr Gly Leu Asp Ala Leu Thr His Cys Ile Glu Ala Tyr Val 
        275                 280                 285             


Ser Thr Ala Ser Asn Pro Ile Thr Asp Ala Cys Ala Leu Lys Gly Ile 
    290                 295                 300                 


Asp Leu Ile Asn Glu Ser Leu Val Ala Ala Tyr Lys Asp Gly Lys Asp 
305                 310                 315                 320 


Lys Lys Ala Arg Thr Asp Met Cys Tyr Ala Glu Tyr Leu Ala Gly Met 
                325                 330                 335     


Ala Phe Asn Asn Ala Ser Leu Gly Tyr Val His Ala Leu Ala His Gln 
            340                 345                 350         


Leu Gly Gly Phe Tyr His Leu Pro His Gly Val Cys Asn Ala Val Leu 
        355                 360                 365             


Leu Pro His Val Gln Glu Ala Asn Met Gln Cys Pro Lys Ala Lys Lys 
    370                 375                 380                 


Arg Leu Gly Glu Ile Ala Leu His Phe Gly Ala Ser Gln Glu Asp Pro 
385                 390                 395                 400 


Glu Glu Thr Ile Lys Ala Leu His Val Leu Asn Arg Thr Met Asn Ile 
                405                 410                 415     


Pro Arg Asn Leu Lys Glu Leu Gly Val Lys Thr Glu Asp Phe Glu Ile 
            420                 425                 430         


Leu Ala Glu His Ala Met His Asp Ala Cys His Leu Thr Asn Pro Val 
        435                 440                 445             


Gln Phe Thr Lys Glu Gln Val Val Ala Ile Ile Lys Lys Ala Tyr Glu 
    450                 455                 460                 


Tyr 
465 


<210>  80
<211>  351
<212>  PRT
<213>  Saccharomyces cerevisiae


<220>
<221>  MISC_FEATURE
<223>  ADH5

<400>  80

Met Pro Ser Gln Val Ile Pro Glu Lys Gln Lys Ala Ile Val Phe Tyr 
1               5                   10                  15      


Glu Thr Asp Gly Lys Leu Glu Tyr Lys Asp Val Thr Val Pro Glu Pro 
            20                  25                  30          


Lys Pro Asn Glu Ile Leu Val His Val Lys Tyr Ser Gly Val Cys His 
        35                  40                  45              


Ser Asp Leu His Ala Trp His Gly Asp Trp Pro Phe Gln Leu Lys Phe 
    50                  55                  60                  


Pro Leu Ile Gly Gly His Glu Gly Ala Gly Val Val Val Lys Leu Gly 
65                  70                  75                  80  


Ser Asn Val Lys Gly Trp Lys Val Gly Asp Phe Ala Gly Ile Lys Trp 
                85                  90                  95      


Leu Asn Gly Thr Cys Met Ser Cys Glu Tyr Cys Glu Val Gly Asn Glu 
            100                 105                 110         


Ser Gln Cys Pro Tyr Leu Asp Gly Thr Gly Phe Thr His Asp Gly Thr 
        115                 120                 125             


Phe Gln Glu Tyr Ala Thr Ala Asp Ala Val Gln Ala Ala His Ile Pro 
    130                 135                 140                 


Pro Asn Val Asn Leu Ala Glu Val Ala Pro Ile Leu Cys Ala Gly Ile 
145                 150                 155                 160 


Thr Val Tyr Lys Ala Leu Lys Arg Ala Asn Val Ile Pro Gly Gln Trp 
                165                 170                 175     


Val Thr Ile Ser Gly Ala Cys Gly Gly Leu Gly Ser Leu Ala Ile Gln 
            180                 185                 190         


Tyr Ala Leu Ala Met Gly Tyr Arg Val Ile Gly Ile Asp Gly Gly Asn 
        195                 200                 205             


Ala Lys Arg Lys Leu Phe Glu Gln Leu Gly Gly Glu Ile Phe Ile Asp 
    210                 215                 220                 


Phe Thr Glu Glu Lys Asp Ile Val Gly Ala Ile Ile Lys Ala Thr Asn 
225                 230                 235                 240 


Gly Gly Ser His Gly Val Ile Asn Val Ser Val Ser Glu Ala Ala Ile 
                245                 250                 255     


Glu Ala Ser Thr Arg Tyr Cys Arg Pro Asn Gly Thr Val Val Leu Val 
            260                 265                 270         


Gly Met Pro Ala His Ala Tyr Cys Asn Ser Asp Val Phe Asn Gln Val 
        275                 280                 285             


Val Lys Ser Ile Ser Ile Val Gly Ser Cys Val Gly Asn Arg Ala Asp 
    290                 295                 300                 


Thr Arg Glu Ala Leu Asp Phe Phe Ala Arg Gly Leu Ile Lys Ser Pro 
305                 310                 315                 320 


Ile His Leu Ala Gly Leu Ser Asp Val Pro Glu Ile Phe Ala Lys Met 
                325                 330                 335     


Glu Lys Gly Glu Ile Val Gly Arg Tyr Val Val Glu Thr Ser Lys 
            340                 345                 350     


