                         SEQUENCE LISTING

<110>  Isis Pharmaceuticals, Inc.
 
<120>  COMPOSITIONS AND METHODS FOR MODULATION OF TARGET NUCLEIC ACIDS

<130>  CORE0116WO

<150>  61/838,190
<151>  2013-06-21

<150>  61/871,683
<151>  2013-08-29

<160>  140   

<170>  PatentIn version 3.5

<210>  1
<211>  3964
<212>  DNA
<213>  Homo sapiens

<400>  1
ctactccagg ctgtgttcag ggcttggggc tggtggaggg aggggcctga aattccagtg       60

tgaaaggctg agatgggccc gaggcccctg gcctatgtcc aagccatttc ccctctcacc      120

agcctctccc tggggagcca gtcagctagg aaggaatgag ggctccccag gcccaccccc      180

agttcctgag ctcatctggg ctgcagggct ggcgggacag cagcgtggac tcagtctcct      240

agggatttcc caactctccc gcccgcttgc tgcatctgga caccctgcct caggccctca      300

tctccactgg tcagcaggtg acctttgccc agcgccctgg gtcctcagtg cctgctgccc      360

tggagatgat ataaaacagg tcagaaccct cctgcctgtc tgctcagttc atccctagag      420

gcagctgctc caggtaatgc cctctgggga ggggaaagag gaggggagga ggatgaagag      480

gggcaagagg agctccctgc ccagcccagc cagcaagcct ggagaagcac ttgctagagc      540

taaggaagcc tcggagctgg acgggtgccc cccacccctc atcataacct gaagaacatg      600

gaggcccggg aggggtgtca cttgcccaaa gctacacagg gggtggggct ggaagtggct      660

ccaagtgcag gttcccccct cattcttcag gcttagggct ggaggaagcc ttagacagcc      720

cagtcctacc ccagacaggg aaactgaggc ctggagaggg ccagaaatca cccaaagaca      780

cacagcatgt tggctggact ggacggagat cagtccagac cgcaggtgcc ttgatgttca      840

gtctggtggg ttttctgctc catcccaccc acctcccttt gggcctcgat ccctcgcccc      900

tcaccagtcc cccttctgag agcccgtatt agcagggagc cggcccctac tccttctggc      960

agacccagct aaggttctac cttaggggcc acgccacctc cccagggagg ggtccagagg     1020

catggggacc tggggtgccc ctcacaggac acttccttgc aggaacagag gtgccatgca     1080

gccccgggta ctccttgttg ttgccctcct ggcgctcctg gcctctgccc gtaagcactt     1140

ggtgggactg ggctgggggc agggtggagg caacttgggg atcccagtcc caatgggtgg     1200

tcaagcagga gcccagggct cgtccagagg ccgatccacc ccactcagcc ctgctctttc     1260

ctcaggagct tcagaggccg aggatgcctc ccttctcagc ttcatgcagg gttacatgaa     1320

gcacgccacc aagaccgcca aggatgcact gagcagcgtg caggagtccc aggtggccca     1380

gcaggccagg tacacccgct ggcctccctc cccatccccc ctgccagctg cctccattcc     1440

cacccgcccc tgccctggtg agatcccaac aatggaatgg aggtgctcca gcctcccctg     1500

ggcctgtgcc tcttcagcct cctctttcct cacagggcct ttgtcaggct gctgcgggag     1560

agatgacaga gttgagactg cattcctccc aggtccctcc tttctccccg gagcagtcct     1620

agggcgtgcc gttttagccc tcatttccat tttcctttcc tttccctttc tttctctttc     1680

tatttctttc tttctttctt tctttctttc tttctttctt tctttctttc tttctttctt     1740

tctttctttc ctttctttct ttcctttctt tctttccttt ctttctttct ttcctttctt     1800

tctctttctt tctttctttc ctttttcttt ctttccctct cttcctttct ctctttcttt     1860

cttcttcttt tttttttaat ggagtctccc tctgtcacct aggctggagt gcagtggtgc     1920

catctcggct cactgcaacc tccgtctccc gggttcaacc cattctcctg cctcagcctc     1980

ccaagtagct gggattacag gcacgcgcca ccacacccag ctaatttttg tatttttagc     2040

agagatgggg tttcaccatg ttggccaggt tggtcttgaa ttcctgacct caggggatcc     2100

tcctgcctcg gcctcccaaa gtgctgggat tacaggcatg agccactgcg cctggcccca     2160

ttttcctttt ctgaaggtct ggctagagca gtggtcctca gcctttttgg caccagggac     2220

cagttttgtg gtggacaatt tttccatggg ccagcgggga tggttttggg atgaagctgt     2280

tccacctcag atcatcaggc attagattct cataaggagc cctccaccta gatccctggc     2340

atgtgcagtt cacaataggg ttcacactcc tatgagaatg taaggccact tgatctgaca     2400

ggaggcggag ctcaggcggt attgctcact cacccaccac tcacttcgtg ctgtgcagcc     2460

cggctcctaa cagtccatgg accagtacct atctatgact tgggggttgg ggacccctgg     2520

gctaggggtt tgccttggga ggccccacct gacccaattc aagcccgtga gtgcttctgc     2580

tttgttctaa gacctggggc cagtgtgagc agaagtgtgt ccttcctctc ccatcctgcc     2640

cctgcccatc agtactctcc tctcccctac tcccttctcc acctcaccct gactggcatt     2700

agctggcata gcagaggtgt tcataaacat tcttagtccc cagaaccggc tttggggtag     2760

gtgttatttt ctcactttgc agatgagaaa attgaggctc agagcgatta ggtgacctgc     2820

cccagatcac acaactaatc aatcctccaa tgactttcca aatgagaggc tgcctccctc     2880

tgtcctaccc tgctcagagc caccaggttg tgcaactcca ggcggtgctg tttgcacaga     2940

aaacaatgac agccttgacc tttcacatct ccccaccctg tcactttgtg cctcaggccc     3000

aggggcataa acatctgagg tgacctggag atggcagggt ttgacttgtg ctggggttcc     3060

tgcaaggata tctcttctcc cagggtggca gctgtggggg attcctgcct gaggtctcag     3120

ggctgtcgtc cagtgaagtt gagagggtgg tgtggtcctg actggtgtcg tccagtgggg     3180

acatgggtgt gggtcccatg gttgcctaca gaggagttct catgccctgc tctgttgctt     3240

cccctgactg atttaggggc tgggtgaccg atggcttcag ttccctgaaa gactactgga     3300

gcaccgttaa ggacaagttc tctgagttct gggatttgga ccctgaggtc agaccaactt     3360

cagccgtggc tgcctgagac ctcaataccc caagtccacc tgcctatcca tcctgcgagc     3420

tccttgggtc ctgcaatctc cagggctgcc cctgtaggtt gcttaaaagg gacagtattc     3480

tcagtgctct cctaccccac ctcatgcctg gcccccctcc aggcatgctg gcctcccaat     3540

aaagctggac aagaagctgc tatgagtggg ccgtcgcaag tgtgccatct gtgtctgggc     3600

atgggaaagg gccgaggctg ttctgtgggt gggcactgga cagactccag gtcaggcagg     3660

catggaggcc agcgctctat ccaccttctg gtagctgggc agtctctggg cctcagtttc     3720

ttcatctcta aggtaggaat caccctccgt accctgcctt ccttgacagc tttgtgcgga     3780

aggtcaaaca ggacaataag tttgctgata ctttgataaa ctgttaggtg ctgcacaaca     3840

tgacttgagt gtgtgcccca tgccagccac tatgcctggc acttaagttg tcatcagagt     3900

tgagactgtg tgtgtttact caaaactgtg gagctgacct cccctatcca ggccccctag     3960

ccct                                                                  3964


<210>  2
<211>  533
<212>  DNA
<213>  Homo sapiens

<400>  2
tgctcagttc atccctagag gcagctgctc caggaacaga ggtgccatgc agccccgggt       60

actccttgtt gttgccctcc tggcgctcct ggcctctgcc cgagcttcag aggccgagga      120

tgcctccctt ctcagcttca tgcagggtta catgaagcac gccaccaaga ccgccaagga      180

tgcactgagc agcgtgcagg agtcccaggt ggcccagcag gccaggggct gggtgaccga      240

tggcttcagt tccctgaaag actactggag caccgttaag gacaagttct ctgagttctg      300

ggatttggac cctgaggtca gaccaacttc agccgtggct gcctgagacc tcaatacccc      360

aagtccacct gcctatccat cctgcgagct ccttgggtcc tgcaatctcc agggctgccc      420

ctgtaggttg cttaaaaggg acagtattct cagtgctctc ctaccccacc tcatgcctgg      480

cccccctcca ggcatgctgg cctcccaata aagctggaca agaagctgct atg             533


<210>  3
<211>  21
<212>  DNA
<213>  Artificial sequence

<220>
<223>  Synthetic oligonucleotide

<400>  3
tcacugagaa uacuguccca a                                                 21


<210>  4
<211>  16
<212>  DNA
<213>  Artificial sequence

<220>
<223>  Primer

<400>  4
gccgtggctg cctgag                                                       16


<210>  5
<211>  19
<212>  DNA
<213>  Artificial sequence

<220>
<223>  Primer

<400>  5
aggagctcgc aggatggat                                                    19


<210>  6
<211>  25
<212>  DNA
<213>  Artificial sequence

<220>
<223>  Probe

<400>  6
cctcaatacc ccaagtccac ctgcc                                             25


<210>  7
<211>  16
<212>  DNA
<213>  Artificial sequence

<220>
<223>  Synthetic oligonucleotide

<400>  7
gcactgagaa tactgt                                                       16


<210>  8
<211>  21
<212>  DNA
<213>  Artificial sequence

<220>
<223>  Synthetic oligonucleotide


<220>
<221>  misc_feature
<222>  (2)..(21)
<223>  bases at these positions are RNA

<400>  8
tgaauacugu cccuuuuaaa a                                                 21


<210>  9
<211>  21
<212>  DNA
<213>  Artificial sequence

<220>
<223>  Synthetic oligonucleotide


<220>
<221>  misc_feature
<222>  (2)..(21)
<223>  bases at these positions are RNA

<400>  9
tagaauacug ucccuuuuaa a                                                 21


<210>  10
<211>  21
<212>  DNA
<213>  Artificial sequence

<220>
<223>  Synthetic oligonucleotide


<220>
<221>  misc_feature
<222>  (2)..(21)
<223>  bases at these positions are RNA

<400>  10
tgagaauacu gucccuuuua a                                                 21


<210>  11
<211>  21
<212>  DNA
<213>  Artificial sequence

<220>
<223>  Synthetic oligonucleotide


<220>
<221>  misc_feature
<222>  (2)..(21)
<223>  bases at these positions are RNA

<400>  11
tcugagaaua cugucccuua a                                                 21


<210>  12
<211>  21
<212>  DNA
<213>  Artificial sequence

<220>
<223>  Synthetic oligonucleotide


<220>
<221>  misc_feature
<222>  (2)..(21)
<223>  bases at these positions are RNA

<400>  12
tugagaauac ugucccuuua a                                                 21


<210>  13
<211>  21
<212>  DNA
<213>  Artificial sequence

<220>
<223>  Synthetic oligonucleotide


<220>
<221>  misc_feature
<222>  (2)..(21)
<223>  bases at these positions are RNA

<400>  13
tgcacugaga auacugucca a                                                 21


<210>  14
<211>  21
<212>  DNA
<213>  Artificial sequence

<220>
<223>  Synthetic oligonucleotide


<220>
<221>  misc_feature
<222>  (2)..(21)
<223>  bases at these positions are RNA

<400>  14
tagcuucuug uccagcuuua a                                                 21


<210>  15
<211>  21
<212>  DNA
<213>  Artificial sequence

<220>
<223>  Synthetic oligonucleotide


<220>
<221>  misc_feature
<222>  (2)..(21)
<223>  bases at these positions are RNA

<400>  15
tacugagaau acugucccua a                                                 21


<210>  16
<211>  21
<212>  DNA
<213>  Artificial sequence

<220>
<223>  Synthetic oligonucleotide


<220>
<221>  misc_feature
<222>  (2)..(21)
<223>  bases at these positions are RNA

<400>  16
tguccagcuu uauugggaga a                                                 21


<210>  17
<211>  21
<212>  DNA
<213>  Artificial sequence

<220>
<223>  Synthetic oligonucleotide


<220>
<221>  misc_feature
<222>  (2)..(21)
<223>  bases at these positions are RNA

<400>  17
tuguccuuaa cggugcucca a                                                 21


<210>  18
<211>  21
<212>  DNA
<213>  Artificial sequence

<220>
<223>  Synthetic oligonucleotide


<220>
<221>  misc_feature
<222>  (2)..(21)
<223>  bases at these positions are RNA

<400>  18
taauacuguc ccuuuuaaga a                                                 21


<210>  19
<211>  21
<212>  DNA
<213>  Artificial sequence

<220>
<223>  Synthetic oligonucleotide


<220>
<221>  misc_feature
<222>  (2)..(21)
<223>  bases at these positions are RNA

<400>  19
tucuugucca gcuuuauuga a                                                 21


<210>  20
<211>  21
<212>  DNA
<213>  Artificial sequence

<220>
<223>  Synthetic oligonucleotide


<220>
<221>  misc_feature
<222>  (2)..(21)
<223>  bases at these positions are RNA

<400>  20
tagcagcuuc uuguccagca a                                                 21


<210>  21
<211>  21
<212>  DNA
<213>  Artificial sequence

<220>
<223>  Synthetic oligonucleotide


<220>
<221>  misc_feature
<222>  (2)..(21)
<223>  bases at these positions are RNA

<400>  21
tuguccagcu uuauugggaa a                                                 21


<210>  22
<211>  21
<212>  DNA
<213>  Artificial sequence

<220>
<223>  Synthetic oligonucleotide


<220>
<221>  misc_feature
<222>  (2)..(21)
<223>  bases at these positions are RNA

<400>  22
tcuuguccag cuuuauugga a                                                 21


<210>  23
<211>  21
<212>  DNA
<213>  Artificial sequence

<220>
<223>  Synthetic oligonucleotide


<220>
<221>  misc_feature
<222>  (2)..(21)
<223>  bases at these positions are RNA

<400>  23
tuucuugucc agcuuuauua a                                                 21


<210>  24
<211>  21
<212>  DNA
<213>  Artificial sequence

<220>
<223>  Synthetic oligonucleotide


<220>
<221>  misc_feature
<222>  (2)..(21)
<223>  bases at these positions are RNA

<400>  24
tgucuuucag ggaacugaaa a                                                 21


<210>  25
<211>  21
<212>  DNA
<213>  Artificial sequence

<220>
<223>  Synthetic oligonucleotide


<220>
<221>  misc_feature
<222>  (2)..(21)
<223>  bases at these positions are RNA

<400>  25
tauagcagcu ucuuguccaa a                                                 21


<210>  26
<211>  21
<212>  DNA
<213>  Artificial sequence

<220>
<223>  Synthetic oligonucleotide


<220>
<221>  misc_feature
<222>  (2)..(21)
<223>  bases at these positions are RNA

<400>  26
taacuugucc uuaacgguga a                                                 21


<210>  27
<211>  21
<212>  DNA
<213>  Artificial sequence

<220>
<223>  Synthetic oligonucleotide


<220>
<221>  misc_feature
<222>  (2)..(21)
<223>  bases at these positions are RNA

<400>  27
tcuucuuguc cagcuuuaua a                                                 21


<210>  28
<211>  21
<212>  DNA
<213>  Artificial sequence

<220>
<223>  Synthetic oligonucleotide


<220>
<221>  misc_feature
<222>  (2)..(21)
<223>  bases at these positions are RNA

<400>  28
tauacugucc cuuuuaagca a                                                 21


<210>  29
<211>  21
<212>  DNA
<213>  Artificial sequence

<220>
<223>  Synthetic oligonucleotide


<220>
<221>  misc_feature
<222>  (2)..(21)
<223>  bases at these positions are RNA

<400>  29
tggccaccug ggacuccuga a                                                 21


<210>  30
<211>  21
<212>  DNA
<213>  Artificial sequence

<220>
<223>  Synthetic oligonucleotide


<220>
<221>  misc_feature
<222>  (2)..(21)
<223>  bases at these positions are RNA

<400>  30
tccucuguuc cuggagcaga a                                                 21


<210>  31
<211>  21
<212>  DNA
<213>  Artificial sequence

<220>
<223>  Synthetic oligonucleotide


<220>
<221>  misc_feature
<222>  (2)..(21)
<223>  bases at these positions are RNA

<400>  31
tgcagcuucu uguccagcua a                                                 21


<210>  32
<211>  21
<212>  DNA
<213>  Artificial sequence

<220>
<223>  Synthetic oligonucleotide


<220>
<221>  misc_feature
<222>  (2)..(21)
<223>  bases at these positions are RNA

<400>  32
tgaacugaag ccaucgguca a                                                 21


<210>  33
<211>  21
<212>  DNA
<213>  Artificial sequence

<220>
<223>  Synthetic oligonucleotide


<220>
<221>  misc_feature
<222>  (2)..(21)
<223>  bases at these positions are RNA

<400>  33
tcagcuucuu guccagcuua a                                                 21


<210>  34
<211>  21
<212>  DNA
<213>  Artificial sequence

<220>
<223>  Synthetic oligonucleotide


<220>
<221>  misc_feature
<222>  (2)..(21)
<223>  bases at these positions are RNA

<400>  34
tuggagcagc ugccucuaga a                                                 21


<210>  35
<211>  21
<212>  DNA
<213>  Artificial sequence

<220>
<223>  Synthetic oligonucleotide


<220>
<221>  misc_feature
<222>  (2)..(21)
<223>  bases at these positions are RNA

<400>  35
tuggccugcu gggccaccua a                                                 21


<210>  36
<211>  21
<212>  DNA
<213>  Artificial sequence

<220>
<223>  Synthetic oligonucleotide


<220>
<221>  misc_feature
<222>  (2)..(21)
<223>  bases at these positions are RNA

<400>  36
tcuuucaggg aacugaagca a                                                 21


<210>  37
<211>  21
<212>  DNA
<213>  Artificial sequence

<220>
<223>  Synthetic oligonucleotide


<220>
<221>  misc_feature
<222>  (2)..(21)
<223>  bases at these positions are RNA

<400>  37
tcagggaacu gaagccauca a                                                 21


<210>  38
<211>  21
<212>  DNA
<213>  Artificial sequence

<220>
<223>  Synthetic oligonucleotide


<220>
<221>  misc_feature
<222>  (2)..(21)
<223>  bases at these positions are RNA

<400>  38
tacugaagcc aucggucaca a                                                 21


<210>  39
<211>  21
<212>  DNA
<213>  Artificial sequence

<220>
<223>  Synthetic oligonucleotide


<220>
<221>  misc_feature
<222>  (2)..(21)
<223>  bases at these positions are RNA

<400>  39
tcauagcagc uucuugucca a                                                 21


<210>  40
<211>  21
<212>  DNA
<213>  Artificial sequence

<220>
<223>  Synthetic oligonucleotide


<220>
<221>  misc_feature
<222>  (2)..(21)
<223>  bases at these positions are RNA

<400>  40
taguagucuu ucagggaaca a                                                 21


<210>  41
<211>  21
<212>  DNA
<213>  Artificial sequence

<220>
<223>  Synthetic oligonucleotide


<220>
<221>  misc_feature
<222>  (2)..(21)
<223>  bases at these positions are RNA

<400>  41
tgccaucggu cacccagcca a                                                 21


<210>  42
<211>  21
<212>  DNA
<213>  Artificial sequence

<220>
<223>  Synthetic oligonucleotide


<220>
<221>  misc_feature
<222>  (2)..(21)
<223>  bases at these positions are RNA

<400>  42
tuccagcuuu auugggagga a                                                 21


<210>  43
<211>  21
<212>  DNA
<213>  Artificial sequence

<220>
<223>  Synthetic oligonucleotide


<220>
<221>  misc_feature
<222>  (2)..(21)
<223>  bases at these positions are RNA

<400>  43
tuuguccagc uuuauuggga a                                                 21


<210>  44
<211>  21
<212>  DNA
<213>  Artificial sequence

<220>
<223>  Synthetic oligonucleotide


<220>
<221>  misc_feature
<222>  (2)..(21)
<223>  bases at these positions are RNA

<400>  44
tugaagccau cggucaccca a                                                 21


<210>  45
<211>  21
<212>  DNA
<213>  Artificial sequence

<220>
<223>  Synthetic oligonucleotide


<220>
<221>  misc_feature
<222>  (2)..(21)
<223>  bases at these positions are RNA

<400>  45
tccaguaguc uuucagggaa a                                                 21


<210>  46
<211>  21
<212>  DNA
<213>  Artificial sequence

<220>
<223>  Synthetic oligonucleotide


<220>
<221>  misc_feature
<222>  (2)..(21)
<223>  bases at these positions are RNA

<400>  46
tgcuucuugu ccagcuuuaa a                                                 21


<210>  47
<211>  21
<212>  DNA
<213>  Artificial sequence

<220>
<223>  Synthetic oligonucleotide


<220>
<221>  misc_feature
<222>  (2)..(21)
<223>  bases at these positions are RNA

<400>  47
tuacuguccc uuuuaagcaa a                                                 21


<210>  48
<211>  21
<212>  DNA
<213>  Artificial sequence

<220>
<223>  Synthetic oligonucleotide


<220>
<221>  misc_feature
<222>  (2)..(21)
<223>  bases at these positions are RNA

<400>  48
tuagucuuuc agggaacuga a                                                 21


<210>  49
<211>  21
<212>  DNA
<213>  Artificial sequence

<220>
<223>  Synthetic oligonucleotide


<220>
<221>  misc_feature
<222>  (2)..(21)
<223>  bases at these positions are RNA

<400>  49
tgguauugag gucucaggca a                                                 21


<210>  50
<211>  21
<212>  DNA
<213>  Artificial sequence

<220>
<223>  Synthetic oligonucleotide


<220>
<221>  misc_feature
<222>  (2)..(21)
<223>  bases at these positions are RNA

<400>  50
taagccaucg gucacccaga a                                                 21


<210>  51
<211>  21
<212>  DNA
<213>  Artificial sequence

<220>
<223>  Synthetic oligonucleotide


<220>
<221>  misc_feature
<222>  (2)..(21)
<223>  bases at these positions are RNA

<400>  51
tuguuccugg agcagcugca a                                                 21


<210>  52
<211>  21
<212>  DNA
<213>  Artificial sequence

<220>
<223>  Synthetic oligonucleotide


<220>
<221>  misc_feature
<222>  (2)..(21)
<223>  bases at these positions are RNA

<400>  52
tuagcagcuu cuuguccaga a                                                 21


<210>  53
<211>  21
<212>  DNA
<213>  Artificial sequence

<220>
<223>  Synthetic oligonucleotide


<220>
<221>  misc_feature
<222>  (2)..(21)
<223>  bases at these positions are RNA

<400>  53
tgggaacuga agccaucgga a                                                 21


<210>  54
<211>  21
<212>  DNA
<213>  Artificial sequence

<220>
<223>  Synthetic oligonucleotide


<220>
<221>  misc_feature
<222>  (2)..(21)
<223>  bases at these positions are RNA

<400>  54
tuuuuaagca accuacagga a                                                 21


<210>  55
<211>  21
<212>  DNA
<213>  Artificial sequence

<220>
<223>  Synthetic oligonucleotide


<220>
<221>  misc_feature
<222>  (2)..(21)
<223>  bases at these positions are RNA

<400>  55
tcuccaguag ucuuucagga a                                                 21


<210>  56
<211>  21
<212>  DNA
<213>  Artificial sequence

<220>
<223>  Synthetic oligonucleotide


<220>
<221>  misc_feature
<222>  (2)..(21)
<223>  bases at these positions are RNA

<400>  56
tugcuccagu agucuuucaa a                                                 21


<210>  57
<211>  21
<212>  DNA
<213>  Artificial sequence

<220>
<223>  Synthetic oligonucleotide


<220>
<221>  misc_feature
<222>  (2)..(21)
<223>  bases at these positions are RNA

<400>  57
tacggugcuc caguagucua a                                                 21


<210>  58
<211>  21
<212>  DNA
<213>  Artificial sequence

<220>
<223>  Synthetic oligonucleotide


<220>
<221>  misc_feature
<222>  (2)..(21)
<223>  bases at these positions are RNA

<400>  58
tacugucccu uuuaagcaaa a                                                 21


<210>  59
<211>  21
<212>  DNA
<213>  Artificial sequence

<220>
<223>  Synthetic oligonucleotide


<220>
<221>  misc_feature
<222>  (2)..(21)
<223>  bases at these positions are RNA

<400>  59
tuccuuaacg gugcuccaga a                                                 21


<210>  60
<211>  21
<212>  DNA
<213>  Artificial sequence

<220>
<223>  Synthetic oligonucleotide


<220>
<221>  misc_feature
<222>  (2)..(21)
<223>  bases at these positions are RNA

<400>  60
tggugcucca guagucuuua a                                                 21


<210>  61
<211>  21
<212>  DNA
<213>  Artificial sequence

<220>
<223>  Synthetic oligonucleotide


<220>
<221>  misc_feature
<222>  (2)..(21)
<223>  bases at these positions are RNA

<400>  61
tuaacggugc uccaguagua a                                                 21


<210>  62
<211>  21
<212>  DNA
<213>  Artificial sequence

<220>
<223>  Synthetic oligonucleotide


<220>
<221>  misc_feature
<222>  (2)..(21)
<223>  bases at these positions are RNA

<400>  62
tuuuaagcaa ccuacaggga a                                                 21


<210>  63
<211>  21
<212>  DNA
<213>  Artificial sequence

<220>
<223>  Synthetic oligonucleotide


<220>
<221>  misc_feature
<222>  (2)..(21)
<223>  bases at these positions are RNA

<400>  63
tcugucccuu uuaagcaaca a                                                 21


<210>  64
<211>  21
<212>  DNA
<213>  Artificial sequence

<220>
<223>  Synthetic oligonucleotide


<220>
<221>  misc_feature
<222>  (2)..(21)
<223>  bases at these positions are RNA

<400>  64
tuauugaggu cucaggcaga a                                                 21


<210>  65
<211>  21
<212>  DNA
<213>  Artificial sequence

<220>
<223>  Synthetic oligonucleotide


<220>
<221>  misc_feature
<222>  (2)..(21)
<223>  bases at these positions are RNA

<400>  65
tcuuguccuu aacggugcua a                                                 21


<210>  66
<211>  21
<212>  DNA
<213>  Artificial sequence

<220>
<223>  Synthetic oligonucleotide


<220>
<221>  misc_feature
<222>  (2)..(21)
<223>  bases at these positions are RNA

<400>  66
tcuuaacggu gcuccaguaa a                                                 21


<210>  67
<211>  21
<212>  DNA
<213>  Artificial sequence

<220>
<223>  Synthetic oligonucleotide


<220>
<221>  misc_feature
<222>  (2)..(21)
<223>  bases at these positions are RNA

<400>  67
tucccuuuua agcaaccuaa a                                                 21


<210>  68
<211>  21
<212>  DNA
<213>  Artificial sequence

<220>
<223>  Synthetic oligonucleotide


<220>
<221>  misc_feature
<222>  (2)..(21)
<223>  bases at these positions are RNA

<400>  68
tcccuuuuaa gcaaccuaca a                                                 21


<210>  69
<211>  21
<212>  DNA
<213>  Artificial sequence

<220>
<223>  Synthetic oligonucleotide


<220>
<221>  misc_feature
<222>  (2)..(21)
<223>  bases at these positions are RNA

<400>  69
tuccucggcc ucugaagcua a                                                 21


<210>  70
<211>  21
<212>  DNA
<213>  Artificial sequence

<220>
<223>  Synthetic oligonucleotide


<220>
<221>  misc_feature
<222>  (2)..(21)
<223>  bases at these positions are RNA

<400>  70
tuugaggucu caggcagcca a                                                 21


<210>  71
<211>  21
<212>  DNA
<213>  Artificial sequence

<220>
<223>  Synthetic oligonucleotide


<220>
<221>  misc_feature
<222>  (2)..(21)
<223>  bases at these positions are RNA

<400>  71
tgucccuuuu aagcaaccua a                                                 21


<210>  72
<211>  21
<212>  DNA
<213>  Artificial sequence

<220>
<223>  Synthetic oligonucleotide


<220>
<221>  misc_feature
<222>  (2)..(21)
<223>  bases at these positions are RNA

<400>  72
tccuuuuaag caaccuacaa a                                                 21


<210>  73
<211>  21
<212>  DNA
<213>  Artificial sequence

<220>
<223>  Synthetic oligonucleotide


<220>
<221>  misc_feature
<222>  (2)..(21)
<223>  bases at these positions are RNA

<400>  73
tugcaggacc caaggagcua a                                                 21


<210>  74
<211>  21
<212>  DNA
<213>  Artificial sequence

<220>
<223>  Synthetic oligonucleotide


<220>
<221>  misc_feature
<222>  (2)..(21)
<223>  bases at these positions are RNA

<400>  74
tcuuuuaagc aaccuacaga a                                                 21


<210>  75
<211>  21
<212>  DNA
<213>  Artificial sequence

<220>
<223>  Synthetic oligonucleotide


<220>
<221>  misc_feature
<222>  (2)..(21)
<223>  bases at these positions are RNA

<400>  75
tgagcagcug ccucuaggga a                                                 21


<210>  76
<211>  21
<212>  DNA
<213>  Artificial sequence

<220>
<223>  Synthetic oligonucleotide


<220>
<221>  misc_feature
<222>  (2)..(21)
<223>  bases at these positions are RNA

<400>  76
tagcugccuc uagggaugaa a                                                 21


<210>  77
<211>  21
<212>  DNA
<213>  Artificial sequence

<220>
<223>  Synthetic oligonucleotide


<220>
<221>  misc_feature
<222>  (2)..(21)
<223>  bases at these positions are RNA

<400>  77
tcugccucua gggaugaaca a                                                 21


<210>  78
<211>  21
<212>  DNA
<213>  Artificial sequence

<220>
<223>  Synthetic oligonucleotide


<220>
<221>  misc_feature
<222>  (2)..(21)
<223>  bases at these positions are RNA

<400>  78
tgcagcugcc ucuagggaua a                                                 21


<210>  79
<211>  21
<212>  DNA
<213>  Artificial sequence

<220>
<223>  Synthetic oligonucleotide


<220>
<221>  misc_feature
<222>  (2)..(21)
<223>  bases at these positions are RNA

<400>  79
tugucccuuu uaagcaacca a                                                 21


<210>  80
<211>  21
<212>  DNA
<213>  Artificial sequence

<220>
<223>  Synthetic oligonucleotide


<220>
<221>  misc_feature
<222>  (2)..(21)
<223>  bases at these positions are RNA

<400>  80
tcauccuugg cggucuugga a                                                 21


<210>  81
<211>  21
<212>  DNA
<213>  Artificial sequence

<220>
<223>  Synthetic oligonucleotide


<220>
<221>  misc_feature
<222>  (2)..(21)
<223>  bases at these positions are RNA

<400>  81
tuccuuggcg gucuugguga a                                                 21


<210>  82
<211>  21
<212>  DNA
<213>  Artificial sequence

<220>
<223>  Synthetic oligonucleotide


<220>
<221>  misc_feature
<222>  (2)..(21)
<223>  bases at these positions are RNA

<400>  82
tucagugcau ccuuggcgga a                                                 21


<210>  83
<211>  21
<212>  DNA
<213>  Artificial sequence

<220>
<223>  Synthetic oligonucleotide


<220>
<221>  misc_feature
<222>  (2)..(21)
<223>  bases at these positions are RNA

<400>  83
tagugcaucc uuggcgguca a                                                 21


<210>  84
<211>  21
<212>  DNA
<213>  Artificial sequence

<220>
<223>  Synthetic oligonucleotide


<220>
<221>  misc_feature
<222>  (2)..(21)
<223>  bases at these positions are RNA

<400>  84
tcuuggcggu cuugguggca a                                                 21


<210>  85
<211>  20
<212>  DNA
<213>  Artificial sequence

<220>
<223>  Synthetic oligonucleotide

<400>  85
ctttccgttg gacccctggg                                                   20


<210>  86
<211>  20
<212>  DNA
<213>  Artificial sequence

<220>
<223>  Synthetic oligonucleotide

<400>  86
gtgcgcgcga gcccgaaatc                                                   20


<210>  87
<211>  19
<212>  RNA
<213>  Artificial sequence

<220>
<223>  Synthetic oligonucleotide

<400>  87
ucccugaaag acuacugga                                                    19


<210>  88
<211>  21
<212>  DNA
<213>  Artificial sequence

<220>
<223>  Synthetic oligonucleotide


<220>
<221>  misc_feature
<222>  (1)..(19)
<223>  bases at these positions are RNA

<400>  88
ugggugaccg auggcuucat t                                                 21


<210>  89
<211>  21
<212>  DNA
<213>  Artificial sequence

<220>
<223>  Synthetic oligonucleotide


<220>
<221>  misc_feature
<222>  (1)..(19)
<223>  bases at these positions are RNA

<400>  89
gauggcuuca guucccugat t                                                 21


<210>  90
<211>  21
<212>  DNA
<213>  Artificial sequence

<220>
<223>  Synthetic oligonucleotide


<220>
<221>  misc_feature
<222>  (1)..(19)
<223>  bases at these positions are RNA

<400>  90
ugcagccccg gguacuccut t                                                 21


<210>  91
<211>  21
<212>  DNA
<213>  Artificial sequence

<220>
<223>  Synthetic oligonucleotide


<220>
<221>  misc_feature
<222>  (1)..(19)
<223>  bases at these positions are RNA

<400>  91
gcagccccgg guacuccuut t                                                 21


<210>  92
<211>  21
<212>  DNA
<213>  Artificial sequence

<220>
<223>  Synthetic oligonucleotide


<220>
<221>  misc_feature
<222>  (1)..(19)
<223>  bases at these positions are RNA

<400>  92
ccgauggcuu caguucccut t                                                 21


<210>  93
<211>  21
<212>  DNA
<213>  Artificial sequence

<220>
<223>  Synthetic oligonucleotide


<220>
<221>  misc_feature
<222>  (1)..(19)
<223>  bases at these positions are RNA

<400>  93
auggcuucag uucccugaat t                                                 21


<210>  94
<211>  21
<212>  DNA
<213>  Artificial sequence

<220>
<223>  Synthetic oligonucleotide


<220>
<221>  misc_feature
<222>  (1)..(19)
<223>  bases at these positions are RNA

<400>  94
uggcuucagu ucccugaaat t                                                 21


<210>  95
<211>  21
<212>  DNA
<213>  Artificial sequence

<220>
<223>  Synthetic oligonucleotide


<220>
<221>  misc_feature
<222>  (1)..(19)
<223>  bases at these positions are RNA

<400>  95
cugaaagacu acuggagcat t                                                 21


<210>  96
<211>  21
<212>  DNA
<213>  Artificial sequence

<220>
<223>  Synthetic oligonucleotide


<220>
<221>  misc_feature
<222>  (1)..(19)
<223>  bases at these positions are RNA

<400>  96
agcaccguua aggacaagut t                                                 21


<210>  97
<211>  21
<212>  DNA
<213>  Artificial sequence

<220>
<223>  Synthetic oligonucleotide


<220>
<221>  misc_feature
<222>  (1)..(19)
<223>  bases at these positions are RNA

<400>  97
gcaccguuaa ggacaaguut t                                                 21


<210>  98
<211>  21
<212>  DNA
<213>  Artificial sequence

<220>
<223>  Synthetic oligonucleotide


<220>
<221>  misc_feature
<222>  (1)..(19)
<223>  bases at these positions are RNA

<400>  98
gcugccugag accucaauat t                                                 21


<210>  99
<211>  21
<212>  DNA
<213>  Artificial sequence

<220>
<223>  Synthetic oligonucleotide


<220>
<221>  misc_feature
<222>  (1)..(19)
<223>  bases at these positions are RNA

<400>  99
cugagaccuc aauaccccat t                                                 21


<210>  100
<211>  21
<212>  DNA
<213>  Artificial sequence

<220>
<223>  Synthetic oligonucleotide


<220>
<221>  misc_feature
<222>  (1)..(19)
<223>  bases at these positions are RNA

<400>  100
gcugccccug uagguugcut t                                                 21


<210>  101
<211>  21
<212>  DNA
<213>  Artificial sequence

<220>
<223>  Synthetic oligonucleotide


<220>
<221>  misc_feature
<222>  (1)..(19)
<223>  bases at these positions are RNA

<400>  101
gcuuaaaagg gacaguauut t                                                 21


<210>  102
<211>  21
<212>  DNA
<213>  Artificial sequence

<220>
<223>  Synthetic oligonucleotide


<220>
<221>  misc_feature
<222>  (1)..(19)
<223>  bases at these positions are RNA

<400>  102
cuggacaaga agcugcuaut t                                                 21


<210>  103
<211>  21
<212>  DNA
<213>  Artificial sequence

<220>
<223>  Synthetic oligonucleotide


<220>
<221>  misc_feature
<222>  (1)..(19)
<223>  bases at these positions are RNA

<400>  103
cccuguaggu ugcuuaaaat t                                                 21


<210>  104
<211>  21
<212>  DNA
<213>  Artificial sequence

<220>
<223>  Synthetic oligonucleotide


<220>
<221>  misc_feature
<222>  (1)..(19)
<223>  bases at these positions are RNA

<400>  104
caagaccgcc aaggaugcat t                                                 21


<210>  105
<211>  21
<212>  DNA
<213>  Artificial sequence

<220>
<223>  Synthetic oligonucleotide


<220>
<221>  misc_feature
<222>  (1)..(19)
<223>  bases at these positions are RNA

<400>  105
ggugaccgau ggcuucagut t                                                 21


<210>  106
<211>  21
<212>  DNA
<213>  Artificial sequence

<220>
<223>  Synthetic oligonucleotide


<220>
<221>  misc_feature
<222>  (1)..(19)
<223>  bases at these positions are RNA

<400>  106
gcuucaguuc ccugaaagat t                                                 21


<210>  107
<211>  21
<212>  DNA
<213>  Artificial sequence

<220>
<223>  Synthetic oligonucleotide


<220>
<221>  misc_feature
<222>  (1)..(19)
<223>  bases at these positions are RNA

<400>  107
ccucaauacc ccaaguccat t                                                 21


<210>  108
<211>  21
<212>  DNA
<213>  Artificial sequence

<220>
<223>  Synthetic oligonucleotide


<220>
<221>  misc_feature
<222>  (1)..(19)
<223>  bases at these positions are RNA

<400>  108
agguugcuua aaagggacat t                                                 21


<210>  109
<211>  21
<212>  DNA
<213>  Artificial sequence

<220>
<223>  Synthetic oligonucleotide


<220>
<221>  misc_feature
<222>  (1)..(19)
<223>  bases at these positions are RNA

<400>  109
ugcuuaaaag ggacaguaut t                                                 21


<210>  110
<211>  21
<212>  DNA
<213>  Artificial sequence

<220>
<223>  Synthetic oligonucleotide


<220>
<221>  misc_feature
<222>  (1)..(19)
<223>  bases at these positions are RNA

<400>  110
agacuacugg agcaccguut t                                                 21


<210>  111
<211>  19
<212>  RNA
<213>  Artificial sequence

<220>
<223>  Synthetic oligonucleotide

<400>  111
uccaguaguc uuucaggga                                                    19


<210>  112
<211>  21
<212>  DNA
<213>  Artificial sequence

<220>
<223>  Synthetic oligonucleotide


<220>
<221>  misc_feature
<222>  (1)..(19)
<223>  bases at these positions are RNA

<400>  112
ugaagccauc ggucacccat t                                                 21


<210>  113
<211>  21
<212>  DNA
<213>  Artificial sequence

<220>
<223>  Synthetic oligonucleotide


<220>
<221>  misc_feature
<222>  (1)..(19)
<223>  bases at these positions are RNA

<400>  113
ucagggaacu gaagccauct t                                                 21


<210>  114
<211>  21
<212>  DNA
<213>  Artificial sequence

<220>
<223>  Synthetic oligonucleotide


<220>
<221>  misc_feature
<222>  (1)..(19)
<223>  bases at these positions are RNA

<400>  114
aggaguaccc ggggcugcat t                                                 21


<210>  115
<211>  21
<212>  DNA
<213>  Artificial sequence

<220>
<223>  Synthetic oligonucleotide


<220>
<221>  misc_feature
<222>  (1)..(19)
<223>  bases at these positions are RNA

<400>  115
aaggaguacc cggggcugct t                                                 21


<210>  116
<211>  21
<212>  DNA
<213>  Artificial sequence

<220>
<223>  Synthetic oligonucleotide


<220>
<221>  misc_feature
<222>  (1)..(19)
<223>  bases at these positions are RNA

<400>  116
agggaacuga agccaucggt t                                                 21


<210>  117
<211>  21
<212>  DNA
<213>  Artificial sequence

<220>
<223>  Synthetic oligonucleotide


<220>
<221>  misc_feature
<222>  (1)..(19)
<223>  bases at these positions are RNA

<400>  117
uucagggaac ugaagccaut t                                                 21


<210>  118
<211>  21
<212>  DNA
<213>  Artificial sequence

<220>
<223>  Synthetic oligonucleotide


<220>
<221>  misc_feature
<222>  (1)..(19)
<223>  bases at these positions are RNA

<400>  118
uuucagggaa cugaagccat t                                                 21


<210>  119
<211>  21
<212>  DNA
<213>  Artificial sequence

<220>
<223>  Synthetic oligonucleotide


<220>
<221>  misc_feature
<222>  (1)..(19)
<223>  bases at these positions are RNA

<400>  119
ugcuccagua gucuuucagt t                                                 21


<210>  120
<211>  21
<212>  DNA
<213>  Artificial sequence

<220>
<223>  Synthetic oligonucleotide


<220>
<221>  misc_feature
<222>  (1)..(19)
<223>  bases at these positions are RNA

<400>  120
acuuguccuu aacggugcut t                                                 21


<210>  121
<211>  21
<212>  DNA
<213>  Artificial sequence

<220>
<223>  Synthetic oligonucleotide


<220>
<221>  misc_feature
<222>  (1)..(19)
<223>  bases at these positions are RNA

<400>  121
aacuuguccu uaacggugct t                                                 21


<210>  122
<211>  21
<212>  DNA
<213>  Artificial sequence

<220>
<223>  Synthetic oligonucleotide


<220>
<221>  misc_feature
<222>  (1)..(19)
<223>  bases at these positions are RNA

<400>  122
uauugagguc ucaggcagct t                                                 21


<210>  123
<211>  21
<212>  DNA
<213>  Artificial sequence

<220>
<223>  Synthetic oligonucleotide


<220>
<221>  misc_feature
<222>  (1)..(19)
<223>  bases at these positions are RNA

<400>  123
ugggguauug aggucucagt t                                                 21


<210>  124
<211>  21
<212>  DNA
<213>  Artificial sequence

<220>
<223>  Synthetic oligonucleotide


<220>
<221>  misc_feature
<222>  (1)..(19)
<223>  bases at these positions are RNA

<400>  124
agcaaccuac aggggcagct t                                                 21


<210>  125
<211>  21
<212>  DNA
<213>  Artificial sequence

<220>
<223>  Synthetic oligonucleotide


<220>
<221>  misc_feature
<222>  (1)..(19)
<223>  bases at these positions are RNA

<400>  125
aauacugucc cuuuuaagct t                                                 21


<210>  126
<211>  21
<212>  DNA
<213>  Artificial sequence

<220>
<223>  Synthetic oligonucleotide


<220>
<221>  misc_feature
<222>  (1)..(19)
<223>  bases at these positions are RNA

<400>  126
auagcagcuu cuuguccagt t                                                 21


<210>  127
<211>  21
<212>  DNA
<213>  Artificial sequence

<220>
<223>  Synthetic oligonucleotide


<220>
<221>  misc_feature
<222>  (1)..(19)
<223>  bases at these positions are RNA

<400>  127
uuuuaagcaa ccuacagggt t                                                 21


<210>  128
<211>  21
<212>  DNA
<213>  Artificial sequence

<220>
<223>  Synthetic oligonucleotide


<220>
<221>  misc_feature
<222>  (2)..(21)
<223>  bases at these positions are RNA

<400>  128
ugcauccuug gcggucuugt t                                                 21


<210>  129
<211>  21
<212>  DNA
<213>  Artificial sequence

<220>
<223>  Synthetic oligonucleotide


<220>
<221>  misc_feature
<222>  (1)..(19)
<223>  bases at these positions are RNA

<400>  129
acugaagcca ucggucacct t                                                 21


<210>  130
<211>  21
<212>  DNA
<213>  Artificial sequence

<220>
<223>  Synthetic oligonucleotide


<220>
<221>  misc_feature
<222>  (1)..(19)
<223>  bases at these positions are RNA

<400>  130
ucuuucaggg aacugaagct t                                                 21


<210>  131
<211>  21
<212>  DNA
<213>  Artificial sequence

<220>
<223>  Synthetic oligonucleotide


<220>
<221>  misc_feature
<222>  (1)..(19)
<223>  bases at these positions are RNA

<400>  131
uggacuuggg guauugaggt t                                                 21


<210>  132
<211>  21
<212>  DNA
<213>  Artificial sequence

<220>
<223>  Synthetic oligonucleotide


<220>
<221>  misc_feature
<222>  (1)..(19)
<223>  bases at these positions are RNA

<400>  132
ugucccuuuu aagcaaccut t                                                 21


<210>  133
<211>  21
<212>  DNA
<213>  Artificial sequence

<220>
<223>  Synthetic oligonucleotide


<220>
<221>  misc_feature
<222>  (1)..(19)
<223>  bases at these positions are RNA

<400>  133
auacuguccc uuuuaagcat t                                                 21


<210>  134
<211>  21
<212>  DNA
<213>  Artificial sequence

<220>
<223>  Synthetic oligonucleotide


<220>
<221>  misc_feature
<222>  (1)..(19)
<223>  bases at these positions are RNA

<400>  134
aacggugcuc caguagucut t                                                 21


<210>  135
<211>  20
<212>  DNA
<213>  Artificial sequence

<220>
<223>  Synthetic oligonucleotide

<400>  135
ctgctagcct ctggatttga                                                   20


<210>  136
<211>  21
<212>  DNA
<213>  Artificial sequence

<220>
<223>  Synthetic oligonucleotide


<220>
<221>  misc_feature
<222>  (2)..(21)
<223>  bases at these positions are RNA

<400>  136
tuaucuauaa ugaucaggua a                                                 21


<210>  137
<211>  23
<212>  DNA
<213>  Artificial sequence

<220>
<223>  Synthetic oligonucleotide


<220>
<221>  misc_feature
<222>  (2)..(22)
<223>  bases at these positions are RNA

<400>  137
tuaucuauaa ugaucaggua aat                                               23


<210>  138
<211>  20
<212>  DNA
<213>  Artificial sequence

<220>
<223>  Synthetic oligonucleotide

<400>  138
agcttcttgt ccagctttat                                                   20


<210>  139
<211>  21
<212>  DNA
<213>  Artificial sequence

<220>
<223>  Synthetic oligonucleotide

<400>  139
tcactgagaa tactgtccca a                                                 21


<210>  140
<211>  23
<212>  DNA
<213>  Artificial sequence

<220>
<223>  Synthetic oligonucleotide


<220>
<221>  misc_feature
<222>  (2)..(4)
<223>  bases at these positions are RNA

<220>
<221>  misc_feature
<222>  (6)..(10)
<223>  bases at these positions are RNA

<220>
<221>  misc_feature
<222>  (12)..(13)
<223>  bases at these positions are RNA

<220>
<221>  misc_feature
<222>  (15)..(15)
<223>  bases at these positions are RNA

<220>
<221>  misc_feature
<222>  (17)..(23)
<223>  bases at these positions are RNA

<400>  140
tcactgagaa tactgtccca aau                                               23


