                         SEQUENCE LISTING

<110>  Broad Institute of harvard and MIT
       Suva, Mario L
       Rheinbay, Esther
       Patel, Anoop P
       Bernstein, Bradley E
 
<120>  COMPOSITIONS AND METHODS FOR DETECTING AND TREATING GLIOBLASTOMA

<130>  364950-1000WO1 (00025)

<150>  US  61/837,527
<151>  2013-06-20

<160>  14    

<170>  PatentIn version 3.5

<210>  1
<211>  317
<212>  PRT
<213>  Homo sapiens

<400>  1

Met Tyr Asn Met Met Glu Thr Glu Leu Lys Pro Pro Gly Pro Gln Gln 
1               5                   10                  15      


Thr Ser Gly Gly Gly Gly Gly Asn Ser Thr Ala Ala Ala Ala Gly Gly 
            20                  25                  30          


Asn Gln Lys Asn Ser Pro Asp Arg Val Lys Arg Pro Met Asn Ala Phe 
        35                  40                  45              


Met Val Trp Ser Arg Gly Gln Arg Arg Lys Met Ala Gln Glu Asn Pro 
    50                  55                  60                  


Lys Met His Asn Ser Glu Ile Ser Lys Arg Leu Gly Ala Glu Trp Lys 
65                  70                  75                  80  


Leu Leu Ser Glu Thr Glu Lys Arg Pro Phe Ile Asp Glu Ala Lys Arg 
                85                  90                  95      


Leu Arg Ala Leu His Met Lys Glu His Pro Asp Tyr Lys Tyr Arg Pro 
            100                 105                 110         


Arg Arg Lys Thr Lys Thr Leu Met Lys Lys Asp Lys Tyr Thr Leu Pro 
        115                 120                 125             


Gly Gly Leu Leu Ala Pro Gly Gly Asn Ser Met Ala Ser Gly Val Gly 
    130                 135                 140                 


Val Gly Ala Gly Leu Gly Ala Gly Val Asn Gln Arg Met Asp Ser Tyr 
145                 150                 155                 160 


Ala His Met Asn Gly Trp Ser Asn Gly Ser Tyr Ser Met Met Gln Asp 
                165                 170                 175     


Gln Leu Gly Tyr Pro Gln His Pro Gly Leu Asn Ala His Gly Ala Ala 
            180                 185                 190         


Gln Met Gln Pro Met His Arg Tyr Asp Val Ser Ala Leu Gln Tyr Asn 
        195                 200                 205             


Ser Met Thr Ser Ser Gln Thr Tyr Met Asn Gly Ser Pro Thr Tyr Ser 
    210                 215                 220                 


Met Ser Tyr Ser Gln Gln Gly Thr Pro Gly Met Ala Leu Gly Ser Met 
225                 230                 235                 240 


Gly Ser Val Val Lys Ser Glu Ala Ser Ser Ser Pro Pro Val Val Thr 
                245                 250                 255     


Ser Ser Ser His Ser Arg Ala Pro Cys Gln Ala Gly Asp Leu Arg Asp 
            260                 265                 270         


Met Ile Ser Met Tyr Leu Pro Gly Ala Glu Val Pro Glu Pro Ala Ala 
        275                 280                 285             


Pro Ser Arg Leu His Met Ser Gln His Tyr Gln Ser Gly Pro Val Pro 
    290                 295                 300                 


Gly Thr Ala Ile Asn Gly Thr Leu Pro Leu Ser His Met 
305                 310                 315         


<210>  2
<211>  2520
<212>  DNA
<213>  Homo sapiens

<400>  2
ggatggttgt ctattaactt gttcaaaaaa gtatcaggag ttgtcaaggc agagaagaga       60

gtgtttgcaa aagggggaaa gtagtttgct gcctctttaa gactaggact gagagaaaga      120

agaggagaga gaaagaaagg gagagaagtt tgagccccag gcttaagcct ttccaaaaaa      180

taataataac aatcatcggc ggcggcagga tcggccagag gaggagggaa gcgctttttt      240

tgatcctgat tccagtttgc ctctctcttt ttttccccca aattattctt cgcctgattt      300

tcctcgcgga gccctgcgct cccgacaccc ccgcccgcct cccctcctcc tctccccccg      360

cccgcgggcc ccccaaagtc ccggccgggc cgagggtcgg cggccgccgg cgggccgggc      420

ccgcgcacag cgcccgcatg tacaacatga tggagacgga gctgaagccg ccgggcccgc      480

agcaaacttc ggggggcggc ggcggcaact ccaccgcggc ggcggccggc ggcaaccaga      540

aaaacagccc ggaccgcgtc aagcggccca tgaatgcctt catggtgtgg tcccgcgggc      600

agcggcgcaa gatggcccag gagaacccca agatgcacaa ctcggagatc agcaagcgcc      660

tgggcgccga gtggaaactt ttgtcggaga cggagaagcg gccgttcatc gacgaggcta      720

agcggctgcg agcgctgcac atgaaggagc acccggatta taaataccgg ccccggcgga      780

aaaccaagac gctcatgaag aaggataagt acacgctgcc cggcgggctg ctggcccccg      840

gcggcaatag catggcgagc ggggtcgggg tgggcgccgg cctgggcgcg ggcgtgaacc      900

agcgcatgga cagttacgcg cacatgaacg gctggagcaa cggcagctac agcatgatgc      960

aggaccagct gggctacccg cagcacccgg gcctcaatgc gcacggcgca gcgcagatgc     1020

agcccatgca ccgctacgac gtgagcgccc tgcagtacaa ctccatgacc agctcgcaga     1080

cctacatgaa cggctcgccc acctacagca tgtcctactc gcagcagggc acccctggca     1140

tggctcttgg ctccatgggt tcggtggtca agtccgaggc cagctccagc ccccctgtgg     1200

ttacctcttc ctcccactcc agggcgccct gccaggccgg ggacctccgg gacatgatca     1260

gcatgtatct ccccggcgcc gaggtgccgg aacccgccgc ccccagcaga cttcacatgt     1320

cccagcacta ccagagcggc ccggtgcccg gcacggccat taacggcaca ctgcccctct     1380

cacacatgtg agggccggac agcgaactgg aggggggaga aattttcaaa gaaaaacgag     1440

ggaaatggga ggggtgcaaa agaggagagt aagaaacagc atggagaaaa cccggtacgc     1500

tcaaaaagaa aaaggaaaaa aaaaaatccc atcacccaca gcaaatgaca gctgcaaaag     1560

agaacaccaa tcccatccac actcacgcaa aaaccgcgat gccgacaaga aaacttttat     1620

gagagagatc ctggacttct ttttggggga ctatttttgt acagagaaaa cctggggagg     1680

gtggggaggg cgggggaatg gaccttgtat agatctggag gaaagaaagc tacgaaaaac     1740

tttttaaaag ttctagtggt acggtaggag ctttgcagga agtttgcaaa agtctttacc     1800

aataatattt agagctagtc tccaagcgac gaaaaaaatg ttttaatatt tgcaagcaac     1860

ttttgtacag tatttatcga gataaacatg gcaatcaaaa tgtccattgt ttataagctg     1920

agaatttgcc aatatttttc aaggagaggc ttcttgctga attttgattc tgcagctgaa     1980

atttaggaca gttgcaaacg tgaaaagaag aaaattattc aaatttggac attttaattg     2040

tttaaaaatt gtacaaaagg aaaaaattag aataagtact ggcgaaccat ctctgtggtc     2100

ttgtttaaaa agggcaaaag ttttagactg tactaaattt tataacttac tgttaaaagc     2160

aaaaatggcc atgcaggttg acaccgttgg taatttataa tagcttttgt tcgatcccaa     2220

ctttccattt tgttcagata aaaaaaacca tgaaattact gtgtttgaaa tattttctta     2280

tggtttgtaa tatttctgta aatttattgt gatattttaa ggttttcccc cctttatttt     2340

ccgtagttgt attttaaaag attcggctct gtattatttg aatcagtctg ccgagaatcc     2400

atgtatatat ttgaactaat atcatcctta taacaggtac attttcaact taagttttta     2460

ctccattatg cacagtttga gataaataaa tttttgaaat atggacactg aaaaaaaaaa     2520


<210>  3
<211>  323
<212>  PRT
<213>  Homo sapiens

<400>  3

Met Asp Ser Asp Ala Ser Leu Val Ser Ser Arg Pro Ser Ser Pro Glu 
1               5                   10                  15      


Pro Asp Asp Leu Phe Leu Pro Ala Arg Ser Lys Gly Ser Ser Gly Ser 
            20                  25                  30          


Ala Phe Thr Gly Gly Thr Val Ser Ser Ser Thr Pro Ser Asp Cys Pro 
        35                  40                  45              


Pro Glu Leu Ser Ala Glu Leu Arg Gly Ala Met Gly Ser Ala Gly Ala 
    50                  55                  60                  


His Pro Gly Asp Lys Leu Gly Gly Ser Gly Phe Lys Ser Ser Ser Ser 
65                  70                  75                  80  


Ser Thr Ser Ser Ser Thr Ser Ser Ala Ala Ala Ser Ser Thr Lys Lys 
                85                  90                  95      


Asp Lys Lys Gln Met Thr Glu Pro Glu Leu Gln Gln Leu Arg Leu Lys 
            100                 105                 110         


Ile Asn Ser Arg Glu Arg Lys Arg Met His Asp Leu Asn Ile Ala Met 
        115                 120                 125             


Asp Gly Leu Arg Glu Val Met Pro Tyr Ala His Gly Pro Ser Val Arg 
    130                 135                 140                 


Lys Leu Ser Lys Ile Ala Thr Leu Leu Leu Ala Arg Asn Tyr Ile Leu 
145                 150                 155                 160 


Met Leu Thr Asn Ser Leu Glu Glu Met Lys Arg Leu Val Ser Glu Ile 
                165                 170                 175     


Tyr Gly Gly His His Ala Gly Phe His Pro Ser Ala Cys Gly Gly Leu 
            180                 185                 190         


Ala His Ser Ala Pro Leu Pro Ala Ala Thr Ala His Pro Ala Ala Ala 
        195                 200                 205             


Ala His Ala Ala His His Pro Ala Val His His Pro Ile Leu Pro Pro 
    210                 215                 220                 


Ala Ala Ala Ala Ala Ala Ala Ala Ala Ala Ala Ala Ala Val Ser Ser 
225                 230                 235                 240 


Ala Ser Leu Pro Gly Ser Gly Leu Pro Ser Val Gly Ser Ile Arg Pro 
                245                 250                 255     


Pro His Gly Leu Leu Lys Ser Pro Ser Ala Ala Ala Ala Ala Pro Leu 
            260                 265                 270         


Gly Gly Gly Gly Gly Gly Ser Gly Ala Ser Gly Gly Phe Gln His Trp 
        275                 280                 285             


Gly Gly Met Pro Cys Pro Cys Ser Met Cys Gln Val Pro Pro Pro His 
    290                 295                 300                 


His His Val Ser Ala Met Gly Ala Gly Ser Leu Pro Arg Leu Thr Ser 
305                 310                 315                 320 


Asp Ala Lys 
            


<210>  4
<211>  2521
<212>  DNA
<213>  Homo sapiens

<400>  4
aaaaaccggc cgagccccta aaggtgcgga tgcttattat agatcgacgc gacaccagcg       60

cccggtgcca ggttctcccc tgaggctttt cggagcgagc tcctcaaatc gcatccagat      120

tttcgggtcc gagggaagga ggaccctgcg aaagctgcga cgactatctt cccctggggc      180

catggactcg gacgccagcc tggtgtccag ccgcccgtcg tcgccagagc ccgatgacct      240

ttttctgccg gcccggagta agggcagcag cggcagcgcc ttcactgggg gcaccgtgtc      300

ctcgtccacc ccgagtgact gcccgccgga gctgagcgcc gagctgcgcg gcgctatggg      360

ctctgcgggc gcgcatcctg gggacaagct aggaggcagt ggcttcaagt catcctcgtc      420

cagcacctcg tcgtctacgt cgtcggcggc tgcgtcgtcc accaagaagg acaagaagca      480

aatgacagag ccggagctgc agcagctgcg tctcaagatc aacagccgcg agcgcaagcg      540

catgcacgac ctcaacatcg ccatggatgg cctccgcgag gtcatgccgt acgcacacgg      600

cccttcggtg cgcaagcttt ccaagatcgc cacgctgctg ctggcgcgca actacatcct      660

catgctcacc aactcgctgg aggagatgaa gcgactggtg agcgagatct acgggggcca      720

ccacgctggc ttccacccgt cggcctgcgg cggcctggcg cactccgcgc ccctgcccgc      780

cgccaccgcg cacccggcag cagcagcgca cgccgcacat caccccgcgg tgcaccaccc      840

catcctgccg cccgccgccg cagcggctgc tgccgccgct gcagccgcgg ctgtgtccag      900

cgcctctctg cccggatccg ggctgccgtc ggtcggctcc atccgtccac cgcacggcct      960

actcaagtct ccgtctgctg ccgcggccgc cccgctgggg ggcgggggcg gcggcagtgg     1020

ggcgagcggg ggcttccagc actggggcgg catgccctgc ccctgcagca tgtgccaggt     1080

gccgccgccg caccaccacg tgtcggctat gggcgccggc agcctgccgc gcctcacctc     1140

cgacgccaag tgagccgact ggcgccggcg cgttctggcg acaggggagc caggggccgc     1200

ggggaagcga ggactggcct gcgctgggct cgggagctct gtcgcgagga ggggcgcagg     1260

accatggact gggggtgggg catggtgggg attccagcat ctgcgaaccc aagcaatggg     1320

ggcgcccaca gagcagtggg gagtgagggg atgttctctc cgggacctga tcgagcgctg     1380

tctggcttta acctgagctg gtccagtaga catcgtttta tgaaaaggta ccgctgtgtg     1440

cattcctcac tagaactcat ccgacccccg acccccacct ccgggaaaag attctaaaaa     1500

cttctttccc tgagagcgtg gcctgacttg cagactcggc ttgggcagca cttcgggggg     1560

ggagggggtg ttatgggagg gggacacatt ggggccttgc tcctcttcct cctttcttgg     1620

cgggtgggag actccgggta gccgcactgc agaagcaaca gcccgaccgc gccctccagg     1680

gtcgtccctg gcccaaggcc aggggccaca agttagttgg aagccggcgt tcggtatcag     1740

aagcgctgat ggtcatatcc aatctcaata tctgggtcaa tccacaccct cttagaactg     1800

tggccgttcc tccctgtctc tcgttgattt gggagaatat ggttttctaa taaatctgtg     1860

gatgttcctt cttcaacagt atgagcaagt ttatagacat tcagagtaga accacttgtg     1920

gattggaata acccaaaact gccgatttca ggggcgggtg cattgtagtt attattttaa     1980

aatagaaact accccaccga ctcatctttc cttctctaag cacaaagtga tttggttatt     2040

ttggtacctg agaacgtaac agaattaaaa ggcagttgct gtggaaacag tttgggttat     2100

ttgggggttc tgttggcttt ttaaaatttt cttttttgga tgtgtaaatt tatcaatgat     2160

gaggtaagtg cgcaatgcta agctgtttgc tcacgtgact gccagcccca tcggagtcta     2220

agccggcttt cctctatttt ggtttatttt tgccacgttt aacacaaatg gtaaactcct     2280

ccacgtgctt cctgcgttcc gtgcaagccg cctcggcgct gcctgcgttg caaactgggc     2340

tttgtagcgt ctgccgtgta acacccttcc tctgatcgca ccgcccctcg cagagagtgt     2400

atcatctgtt ttatttttgt aaaaacaaag tgctaaataa tatttattac ttgtttggtt     2460

gcaaaaacgg aataaatgac tgagtgttga gattttaaat aaaatttaaa gtaaaaaaaa     2520

a                                                                     2521


<210>  5
<211>  443
<212>  PRT
<213>  Homo sapiens

<400>  5

Met Ala Thr Ala Ala Ser Asn His Tyr Ser Leu Leu Thr Ser Ser Ala 
1               5                   10                  15      


Ser Ile Val His Ala Glu Pro Pro Gly Gly Met Gln Gln Gly Ala Gly 
            20                  25                  30          


Gly Tyr Arg Glu Ala Gln Ser Leu Val Gln Gly Asp Tyr Gly Ala Leu 
        35                  40                  45              


Gln Ser Asn Gly His Pro Leu Ser His Ala His Gln Trp Ile Thr Ala 
    50                  55                  60                  


Leu Ser His Gly Gly Gly Gly Gly Gly Gly Gly Gly Gly Gly Gly Gly 
65                  70                  75                  80  


Gly Gly Gly Gly Gly Gly Gly Gly Asp Gly Ser Pro Trp Ser Thr Ser 
                85                  90                  95      


Pro Leu Gly Gln Pro Asp Ile Lys Pro Ser Val Val Val Gln Gln Gly 
            100                 105                 110         


Gly Arg Gly Asp Glu Leu His Gly Pro Gly Ala Leu Gln Gln Gln His 
        115                 120                 125             


Gln Gln Gln Gln Gln Gln Gln Gln Gln Gln Gln Gln Gln Gln Gln Gln 
    130                 135                 140                 


Gln Gln Gln Gln Gln Arg Pro Pro His Leu Val His His Ala Ala Asn 
145                 150                 155                 160 


His His Pro Gly Pro Gly Ala Trp Arg Ser Ala Ala Ala Ala Ala His 
                165                 170                 175     


Leu Pro Pro Ser Met Gly Ala Ser Asn Gly Gly Leu Leu Tyr Ser Gln 
            180                 185                 190         


Pro Ser Phe Thr Val Asn Gly Met Leu Gly Ala Gly Gly Gln Pro Ala 
        195                 200                 205             


Gly Leu His His His Gly Leu Arg Asp Ala His Asp Glu Pro His His 
    210                 215                 220                 


Ala Asp His His Pro His Pro His Ser His Pro His Gln Gln Pro Pro 
225                 230                 235                 240 


Pro Pro Pro Pro Pro Gln Gly Pro Pro Gly His Pro Gly Ala His His 
                245                 250                 255     


Asp Pro His Ser Asp Glu Asp Thr Pro Thr Ser Asp Asp Leu Glu Gln 
            260                 265                 270         


Phe Ala Lys Gln Phe Lys Gln Arg Arg Ile Lys Leu Gly Phe Thr Gln 
        275                 280                 285             


Ala Asp Val Gly Leu Ala Leu Gly Thr Leu Tyr Gly Asn Val Phe Ser 
    290                 295                 300                 


Gln Thr Thr Ile Cys Arg Phe Glu Ala Leu Gln Leu Ser Phe Lys Asn 
305                 310                 315                 320 


Met Cys Lys Leu Lys Pro Leu Leu Asn Lys Trp Leu Glu Glu Ala Asp 
                325                 330                 335     


Ser Ser Ser Gly Ser Pro Thr Ser Ile Asp Lys Ile Ala Ala Gln Gly 
            340                 345                 350         


Arg Lys Arg Lys Lys Arg Thr Ser Ile Glu Val Ser Val Lys Gly Ala 
        355                 360                 365             


Leu Glu Ser His Phe Leu Lys Cys Pro Lys Pro Ser Ala Gln Glu Ile 
    370                 375                 380                 


Thr Ser Leu Ala Asp Ser Leu Gln Leu Glu Lys Glu Val Val Arg Val 
385                 390                 395                 400 


Trp Phe Cys Asn Arg Arg Gln Lys Glu Lys Arg Met Thr Pro Pro Gly 
                405                 410                 415     


Gly Thr Leu Pro Gly Ala Glu Asp Val Tyr Gly Gly Ser Arg Asp Thr 
            420                 425                 430         


Pro Pro His His Gly Val Gln Thr Pro Val Gln 
        435                 440             


<210>  6
<211>  4108
<212>  DNA
<213>  Homo sapiens

<400>  6
agtaatagca ggagcagcaa cagaaggcgt cggagcgggc gtcggagctg cccgctgtgg       60

gagagagagg agacagaaag agcgagcgag gagagggagc ccgaggcgaa aaagtaactg      120

tcaaatgcgc ggctccttta accggagcgc tcagtccggc tccgagagtc atggcgaccg      180

cagcgtctaa ccactacagc ctgctcacct ccagcgcctc catcgtgcac gccgagccgc      240

ccggcggcat gcagcagggc gcggggggct accgcgaagc gcagagcctg gtgcagggcg      300

actacggcgc tctgcagagc aacggacacc cgctcagcca cgctcaccag tggatcaccg      360

cgctgtccca cggcggcggc ggcgggggcg gtggcggcgg cggggggggc gggggcggcg      420

gcgggggcgg cggcgacggc tccccgtggt ccaccagccc cctgggccag ccggacatca      480

agccctcggt ggtggtgcag cagggcggcc gcggagacga gctgcacggg ccaggcgccc      540

tgcagcagca gcatcagcag cagcaacagc aacagcagca gcaacagcag caacagcagc      600

agcagcagca gcaacagcgg ccgccgcatc tggtgcacca cgccgctaac caccacccgg      660

gacccggggc atggcggagc gcggcggctg cagcgcacct cccaccctcc atgggagcgt      720

ccaacggcgg cttgctctac tcgcagccca gcttcacggt gaacggcatg ctgggcgccg      780

gcgggcagcc ggccggtctg caccaccacg gcctgcggga cgcgcacgac gagccacacc      840

atgccgacca ccacccgcac ccgcactcgc acccacacca gcagccgccg cccccgccgc      900

ccccgcaggg tccgcctggc cacccaggcg cgcaccacga cccgcactcg gacgaggaca      960

cgccgacctc ggacgacctg gagcagttcg ccaagcagtt caagcagcgg cggatcaaac     1020

tgggatttac ccaagcggac gtggggctgg ctctgggcac cctgtatggc aacgtgttct     1080

cgcagaccac catctgcagg tttgaggccc tgcagctgag cttcaagaac atgtgcaagc     1140

tgaagccttt gttgaacaag tggttggagg aggcggactc gtcctcgggc agccccacga     1200

gcatagacaa gatcgcagcg caagggcgca agcggaaaaa gcggacctcc atcgaggtga     1260

gcgtcaaggg ggctctggag agccatttcc tcaaatgccc caagccctcg gcccaggaga     1320

tcacctccct cgcggacagc ttacagctgg agaaggaggt ggtgagagtt tggttttgta     1380

acaggagaca gaaagagaaa aggatgaccc ctcccggagg gactctgccg ggcgccgagg     1440

atgtgtacgg ggggagtagg gacactccac cacaccacgg ggtgcagacg cccgtccagt     1500

gaactcgagc tgggggaggg gcagagcgcg gggctccccc tccccttcgg tccttggccc     1560

tttcccggcc ctcttgttcc ctctctaact tctgattgtt cttttatttt taattattat     1620

ttccccgtcc cttaaaaaga caaaaaaaat aaggcaaaag gaaagcaact aagacactgg     1680

actatccttt aaaggtagca ggtgtaatga tgtgttttga cctttgcagg cgagtaacca     1740

ggcaatggag tggagtgtct cctggagaga gtgaggagag tgtgtgatag ctagaaagag     1800

agagagacag agagatggca agcactgaga taaatacctg gcaaaactaa ataaattacc     1860

aaaaaggaaa aaaaatccac caaaccatga taaacacaaa atgcagcttc ctgatgctta     1920

gagttggcac atgctgctgt gtttatttat tgtggattcc catcaggaaa gaggaaaaaa     1980

tacacatgtt ctttcatata ggcaaaattt aaccacataa atttgcactg caagaaaatt     2040

gaagtttacg tgaacaaatt catgagcata ttttctcttt ctccccaccg ttaatttggg     2100

agttgccgtt ttgggggatt ttgttttgct ttgctttatt catcggagag agttgaagcc     2160

agctcttggc cactctccat ttctaatgtt cttgtgttgc cccttcttcg tactgtttgt     2220

gaactttggt taccttcaca ttccccttac gagggtgtaa catctatttg ttcctcttac     2280

caaagcaaaa ggattggctt catacaaaat agacaattct ctgatttcag gaaatgtgca     2340

tggtctaccc gctttatcga aggcaagaat ccggtttgga atataaaaat aagcattggt     2400

tgttcttacc agccacaaag taaacttcat tttcaggcag tgtttctggg ggaggttatg     2460

gagggaagaa aaaagaaaaa tcgatagtga gtgactgatt gcttcatttt atcaggcggg     2520

cccattgtga aagagctcag gggaaatgtg gaggttaaat atatttccag agttgtccag     2580

cagaaagaaa gtggcacttt gaagagaact agggaagtac atatcttcag atatccctat     2640

atagttctct accttcagtt ttagtaacaa ttatgaagaa ttatttgtgc tgacagcagc     2700

agttaaactt tgtttctcta atagcttttt ttttacataa aaaaagaccc aggaacttaa     2760

tagtgtatgc ataagactgt gttttttagc acacagatac ccacagcata cactgacgat     2820

ctccacgcag tagacaggtt ttgtcttcac tagctcattt gtttatcaag tcatatttag     2880

ggtcccacac cctcttttcc tgtaatttat tgcagaatac accactttga cttggacagc     2940

tttctgcccc ctctttcact aaggaaggca aatgaagtga aaaaaaaaaa tgccattttc     3000

aatccttcct ttctcccctt tgttaatagt tttaagtgaa tttttgacct tatcttaatg     3060

gaaaacggtt aactccaaac acaaaagact ctactggaaa gtgtaggtga aaaaacttgt     3120

aactgtattg aaaataaata ccattaaact gtgatcagtt aaaatttaaa agaaaaatca     3180

gcacaaaagg gcgctaaaag ggaaaacact ttttattaat cttaaaagtt tgggggtttt     3240

tttccagtta ggtattagat aaatttttat tttaaaaaat gaaagtctca ctaccataaa     3300

attatggttc agcatcagat tagcattgca ctcagtagtc tttaaggttt taggaaatat     3360

gctttatatt gtcttttcaa acacctgtga ttgtttcatt ttccatgttt ttgcaagata     3420

aatggtgact tataatgggc atatttattt gcctgtattt catttccccc aatgaatgtc     3480

acaaggagat gggcacggag ctgcttcggg tgcatcacgc tgctcgttcc tgaggtatgg     3540

gaactggcct ttagtgaagc tatccagagc agggcaaata gccactggta aagggaggaa     3600

atgaatttcc agatacttat taccaagtag gtaaggtcag aagctggagt tcagagaatg     3660

tgtctacagc ttctctgact cttataggtt tactaagatg aaagttacca ctgaacctta     3720

ccactatgta tatatgttta atatctgtct tttgaaatgc agaaatagtt taaatgtttc     3780

tttgtctatt tttctttttt tttaatgcta cccagggaaa tattttcata tcatttttaa     3840

gtggcctgcc tcaatgtata tttatttctt ttgaaacaaa aaggttctgg aaactgtttt     3900

tctgtagctt taaatgaata ggtgagcaaa atctatatgg gatgtaattt ttttgttcag     3960

tctcttaaaa aatactttgt tttggtacat ttggttgtgc ttgtggggaa aataaaaacg     4020

cagagatcct tatatattta tgttaaagta atattttatt atctacataa aacagaaatg     4080

cacaataaaa aaaaaaaaaa aaaaaaaa                                        4108


<210>  7
<211>  1007
<212>  PRT
<213>  Homo sapiens

<400>  7

Met Ser Arg Arg Lys Gln Arg Lys Pro Gln Gln Leu Ile Ser Asp Cys 
1               5                   10                  15      


Glu Gly Pro Ser Ala Ser Glu Asn Gly Asp Ala Ser Glu Glu Asp His 
            20                  25                  30          


Pro Gln Val Cys Ala Lys Cys Cys Ala Gln Phe Thr Asp Pro Thr Glu 
        35                  40                  45              


Phe Leu Ala His Gln Asn Ala Cys Ser Thr Asp Pro Pro Val Met Val 
    50                  55                  60                  


Ile Ile Gly Gly Gln Glu Asn Pro Asn Asn Ser Ser Ala Ser Ser Glu 
65                  70                  75                  80  


Pro Arg Pro Glu Gly His Asn Asn Pro Gln Val Met Asp Thr Glu His 
                85                  90                  95      


Ser Asn Pro Pro Asp Ser Gly Ser Ser Val Pro Thr Asp Pro Thr Trp 
            100                 105                 110         


Gly Pro Glu Arg Arg Gly Glu Glu Ser Pro Gly His Phe Leu Val Ala 
        115                 120                 125             


Ala Thr Gly Thr Ala Ala Gly Gly Gly Gly Gly Leu Ile Leu Ala Ser 
    130                 135                 140                 


Pro Lys Leu Gly Ala Thr Pro Leu Pro Pro Glu Ser Thr Pro Ala Pro 
145                 150                 155                 160 


Pro Pro Pro Pro Pro Pro Pro Pro Pro Pro Gly Val Gly Ser Gly His 
                165                 170                 175     


Leu Asn Ile Pro Leu Ile Leu Glu Glu Leu Arg Val Leu Gln Gln Arg 
            180                 185                 190         


Gln Ile His Gln Met Gln Met Thr Glu Gln Ile Cys Arg Gln Val Leu 
        195                 200                 205             


Leu Leu Gly Ser Leu Gly Gln Thr Val Gly Ala Pro Ala Ser Pro Ser 
    210                 215                 220                 


Glu Leu Pro Gly Thr Gly Thr Ala Ser Ser Thr Lys Pro Leu Leu Pro 
225                 230                 235                 240 


Leu Phe Ser Pro Ile Lys Pro Val Gln Thr Ser Lys Thr Leu Ala Ser 
                245                 250                 255     


Ser Ser Ser Ser Ser Ser Ser Ser Ser Gly Ala Glu Thr Pro Lys Gln 
            260                 265                 270         


Ala Phe Phe His Leu Tyr His Pro Leu Gly Ser Gln His Pro Phe Ser 
        275                 280                 285             


Ala Gly Gly Val Gly Arg Ser His Lys Pro Thr Pro Ala Pro Ser Pro 
    290                 295                 300                 


Ala Leu Pro Gly Ser Thr Asp Gln Leu Ile Ala Ser Pro His Leu Ala 
305                 310                 315                 320 


Phe Pro Ser Thr Thr Gly Leu Leu Ala Ala Gln Cys Leu Gly Ala Ala 
                325                 330                 335     


Arg Gly Leu Glu Ala Thr Ala Ser Pro Gly Leu Leu Lys Pro Lys Asn 
            340                 345                 350         


Gly Ser Gly Glu Leu Ser Tyr Gly Glu Val Met Gly Pro Leu Glu Lys 
        355                 360                 365             


Pro Gly Gly Arg His Lys Cys Arg Phe Cys Ala Lys Val Phe Gly Ser 
    370                 375                 380                 


Asp Ser Ala Leu Gln Ile His Leu Arg Ser His Thr Gly Glu Arg Pro 
385                 390                 395                 400 


Tyr Lys Cys Asn Val Cys Gly Asn Arg Phe Thr Thr Arg Gly Asn Leu 
                405                 410                 415     


Lys Val His Phe His Arg His Arg Glu Lys Tyr Pro His Val Gln Met 
            420                 425                 430         


Asn Pro His Pro Val Pro Glu His Leu Asp Tyr Val Ile Thr Ser Ser 
        435                 440                 445             


Gly Leu Pro Tyr Gly Met Ser Val Pro Pro Glu Lys Ala Glu Glu Glu 
    450                 455                 460                 


Ala Ala Thr Pro Gly Gly Gly Val Glu Arg Lys Pro Leu Val Ala Ser 
465                 470                 475                 480 


Thr Thr Ala Leu Ser Ala Thr Glu Ser Leu Thr Leu Leu Ser Thr Ser 
                485                 490                 495     


Ala Gly Thr Ala Thr Ala Pro Gly Leu Pro Ala Phe Asn Lys Phe Val 
            500                 505                 510         


Leu Met Lys Ala Val Glu Pro Lys Asn Lys Ala Asp Glu Asn Thr Pro 
        515                 520                 525             


Pro Gly Ser Glu Gly Ser Ala Ile Ser Gly Val Ala Glu Ser Ser Thr 
    530                 535                 540                 


Ala Thr Arg Met Gln Leu Ser Lys Leu Val Thr Ser Leu Pro Ser Trp 
545                 550                 555                 560 


Ala Leu Leu Thr Asn His Phe Lys Ser Thr Gly Ser Phe Pro Phe Pro 
                565                 570                 575     


Tyr Val Leu Glu Pro Leu Gly Ala Ser Pro Ser Glu Thr Ser Lys Leu 
            580                 585                 590         


Gln Gln Leu Val Glu Lys Ile Asp Arg Gln Gly Ala Val Ala Val Thr 
        595                 600                 605             


Ser Ala Ala Ser Gly Ala Pro Thr Thr Ser Ala Pro Ala Pro Ser Ser 
    610                 615                 620                 


Ser Ala Ser Ser Gly Pro Asn Gln Cys Val Ile Cys Leu Arg Val Leu 
625                 630                 635                 640 


Ser Cys Pro Arg Ala Leu Arg Leu His Tyr Gly Gln His Gly Gly Glu 
                645                 650                 655     


Arg Pro Phe Lys Cys Lys Val Cys Gly Arg Ala Phe Ser Thr Arg Gly 
            660                 665                 670         


Asn Leu Arg Ala His Phe Val Gly His Lys Ala Ser Pro Ala Ala Arg 
        675                 680                 685             


Ala Gln Asn Ser Cys Pro Ile Cys Gln Lys Lys Phe Thr Asn Ala Val 
    690                 695                 700                 


Thr Leu Gln Gln His Val Arg Met His Leu Gly Gly Gln Ile Pro Asn 
705                 710                 715                 720 


Gly Gly Thr Ala Leu Pro Glu Gly Gly Gly Ala Ala Gln Glu Asn Gly 
                725                 730                 735     


Ser Glu Gln Ser Thr Val Ser Gly Ala Gly Ser Phe Pro Gln Gln Gln 
            740                 745                 750         


Ser Gln Gln Pro Ser Pro Glu Glu Glu Leu Ser Glu Glu Glu Glu Glu 
        755                 760                 765             


Glu Asp Glu Glu Glu Glu Glu Asp Val Thr Asp Glu Asp Ser Leu Ala 
    770                 775                 780                 


Gly Arg Gly Ser Glu Ser Gly Gly Glu Lys Ala Ile Ser Val Arg Gly 
785                 790                 795                 800 


Asp Ser Glu Glu Ala Ser Gly Ala Glu Glu Glu Val Gly Thr Val Ala 
                805                 810                 815     


Ala Ala Ala Thr Ala Gly Lys Glu Met Asp Ser Asn Glu Lys Thr Thr 
            820                 825                 830         


Gln Gln Ser Ser Leu Pro Pro Pro Pro Pro Pro Asp Ser Leu Asp Gln 
        835                 840                 845             


Pro Gln Pro Met Glu Gln Gly Ser Ser Gly Val Leu Gly Gly Lys Glu 
    850                 855                 860                 


Glu Gly Gly Lys Pro Glu Arg Ser Ser Ser Pro Ala Ser Ala Leu Thr 
865                 870                 875                 880 


Pro Glu Gly Glu Ala Thr Ser Val Thr Leu Val Glu Glu Leu Ser Leu 
                885                 890                 895     


Gln Glu Ala Met Arg Lys Glu Pro Gly Glu Ser Ser Ser Arg Lys Ala 
            900                 905                 910         


Cys Glu Val Cys Gly Gln Ala Phe Pro Ser Gln Ala Ala Leu Glu Glu 
        915                 920                 925             


His Gln Lys Thr His Pro Lys Glu Gly Pro Leu Phe Thr Cys Val Phe 
    930                 935                 940                 


Cys Arg Gln Gly Phe Leu Glu Arg Ala Thr Leu Lys Lys His Met Leu 
945                 950                 955                 960 


Leu Ala His His Gln Val Gln Pro Phe Ala Pro His Gly Pro Gln Asn 
                965                 970                 975     


Ile Ala Ala Leu Ser Leu Val Pro Gly Cys Ser Pro Ser Ile Thr Ser 
            980                 985                 990         


Thr Gly Leu Ser Pro Phe Pro Arg  Lys Asp Asp Pro Thr  Ile Pro 
        995                 1000                 1005         


<210>  8
<211>  4931
<212>  DNA
<213>  Homo sapiens

<400>  8
gagctgcaga agcgtaggga agaagctgaa gaaaaaaagg gggcgtctcc cctttaaaga       60

cttgcaaaga ttgagagaga aagagagaga gtcaagaaca gagaatcaga gagagagaga      120

gagtctgtgt ctctgggaaa gaagaacatc tctgcttcac agtgatttgc gctgggggag      180

aggcatcaat tggcttcgga cccaaggggg agacgagacc aggtcacccc ggttaagacc      240

aagtgagcgt tgcccctccc tctcccaact ctctacccgg gaatgtctcg gcgaaagcag      300

cggaaacccc aacagttaat ctcggactgc gaaggtccca gcgcgtctga gaacggtgat      360

gctagcgagg aggatcaccc ccaagtctgt gccaagtgct gcgcacaatt cactgaccca      420

actgaattcc tcgcccacca gaacgcatgt tctactgacc ctcctgtaat ggtgataatt      480

gggggccagg agaaccccaa caactcttcg gcctcctctg aaccccggcc tgagggtcac      540

aataatcctc aggtcatgga cacagagcat agcaaccccc cagattctgg gtcctccgtg      600

cccacggatc ccacctgggg cccagagagg agaggagagg agtctccagg gcatttcctg      660

gtcgctgcca caggtacagc ggctggggga ggcgggggcc tgatcttggc cagtcccaag      720

ctgggagcaa ccccattacc tccagaatcg acccctgcac cccctcctcc tccaccaccc      780

cctccgcccc caggggtagg cagtggccac ttgaatatcc ccctgatctt ggaagagcta      840

cgggtgctgc agcagcggca gatccatcag atgcagatga ctgagcaaat ctgcaggcag      900

gtgctgttgc ttggctcctt aggccagacg gtgggtgccc ctgccagtcc ctcagagcta      960

cctgggacag ggactgcctc ttccaccaag cccctactac ccctcttcag ccccatcaag     1020

cctgtccaaa ccagcaagac actggcatct tcctcctcct cctcctcttc ctcttcaggg     1080

gcagaaacgc ccaagcaggc cttcttccac ctttaccacc cactggggtc acagcatcct     1140

ttctctgctg gaggggttgg gcgaagccac aaacccaccc ctgccccttc cccagccttg     1200

ccaggcagca cagatcagct gattgcctcg cctcatctgg cattcccaag caccacggga     1260

ctactggcag cacagtgtct tggggcagcc cgaggccttg aggccactgc ctccccaggg     1320

ctcctgaagc caaagaatgg aagtggtgag ctgagctacg gagaagtgat gggtcccttg     1380

gagaagcctg gtggaaggca caaatgccgc ttctgtgcca aagtatttgg cagtgacagt     1440

gccctgcaga tccaccttcg ttcccacacg ggtgagaggc cctataagtg caatgtctgt     1500

ggaaaccgtt ttaccacccg tggcaacctc aaagtgcatt tccaccggca tcgtgagaag     1560

tacccacatg tgcagatgaa cccacaccca gtaccagagc acctagacta tgtcattacc     1620

agcagtggct tgccttatgg tatgtccgtg ccaccagaga aggccgagga ggaggcagcc     1680

actccaggtg gaggggttga gcgcaagcct ctggtggcct ccacaacagc actcagtgcc     1740

acagagagcc tgactctgct ctccaccagt gcaggcacag ccacggctcc aggactccct     1800

gctttcaata agtttgtgct catgaaagca gtggaaccca agaataaagc tgatgaaaac     1860

acccccccag ggagtgaggg ctcagccatc agtggagtgg cagaaagtag cacggcaact     1920

cgcatgcaac taagtaagtt ggtgacttca ctaccaagct gggcactgct taccaaccac     1980

ttcaagtcca ctggcagctt ccccttcccc tatgtgctag agcccttggg ggcctcaccc     2040

tctgagacat caaagctgca gcaactggta gaaaagattg accggcaagg agctgtggcg     2100

gtgacctcag ctgcctcagg agcccccacc acctctgccc ctgcaccttc atcctcagcc     2160

tcttctggac ctaaccagtg tgtcatctgt ctccgagtgc ttagctgtcc tcgggcccta     2220

cgccttcatt atggccaaca tggaggtgag aggcccttca aatgcaaagt gtgtggcaga     2280

gccttctcca ccaggggtaa tctgcgtgca catttcgtgg gccacaaggc cagtccagct     2340

gcccgggcac agaattcctg ccccatctgc cagaagaagt tcaccaatgc tgtcactctg     2400

cagcagcatg tccggatgca cctggggggc cagatcccca acggtggtac tgcactccct     2460

gaaggtggag gagctgctca ggagaatggc tccgagcaat ctacagtctc cggggcaggg     2520

agtttccccc agcagcagtc ccagcagcca tcaccggaag aggagttgtc tgaggaggag     2580

gaagaggagg atgaggaaga agaggaagat gtgactgatg aagattccct ggcagggaga     2640

ggctcagaga gtggaggtga gaaggcaata tcagtgagag gtgattcaga agaggcatct     2700

ggggcagagg aggaggtggg gacagtggcg gcagcagcca cagctgggaa ggagatggac     2760

agtaatgaga aaactactca acagtcttct ttgccaccac caccaccacc tgacagcctg     2820

gatcagcctc agccaatgga gcagggaagc agtggtgttt taggaggcaa ggaagagggg     2880

ggcaaaccgg agagaagctc aagtccggca tcagcactca ccccagaagg ggaagccacc     2940

agcgtgacct tggtagagga gctgagcctg caggaggcaa tgagaaagga gccaggagag     3000

agcagcagca gaaaggcctg cgaagtgtgt ggccaggcct ttccctccca ggcagctctg     3060

gaggagcatc agaagaccca ccccaaggag gggccgctct tcacttgtgt tttctgcagg     3120

cagggctttc ttgagcgggc taccctcaag aagcatatgc tcctggcaca ccaccaggta     3180

cagccctttg ccccccatgg ccctcagaat attgctgctc tttctctagt ccctggctgt     3240

tcgccttcca tcacctccac agggctctcc ccctttcccc gaaaagatga ccccacgatc     3300

ccatgagcct gtttttctgt acctgctgct ctttgtccca cagagcagaa acagcttcac     3360

aaaaggacct cccagagtta tgagccctga ttttgtcttt ttctctaagt tcttaacatg     3420

ttatgtccct agtggctttt ctgtagtccc tgagcttgga aattactgtg cttacaaggg     3480

gatggccccc taaggaattt ttcttccctc ctcattcttt gtacctgagg aacatagatt     3540

ctctgcagct ttctcaaggg gaaccctctc cagcttccct ggtgtgaccc ttcttccccc     3600

tcctctctcc tctccctttc cctttggtag gtgcacctga gcacctacat ttggcattgc     3660

agcctagcca aaaagggctg gcagctgtct ctggagggcc cagtgccact cctctggggt     3720

gacctttctg ctcagctggt gggtatgggt cccctatctt tctagaacca gtatgtggca     3780

ttcctgtcaa atggcctgcc catgaagccc tggaattcca gctccacctc cactaccact     3840

ccaagcctgg ccccaccagt gctgtttggc ctaggaactg tggctgggaa ggtgcctcca     3900

acaatgggat ccagggaagc caaggagaag acagcccccc tcctatttca gcctcctgca     3960

cccaaggcag tgcctgagaa gcccatcata gacaagaagt agcaaactgt acattccttc     4020

ttcctccccc tgctccagaa ggtgccggta ctgaagatgc tccagtaatt ggtgacccaa     4080

ccctaggaag tagggagaaa tgaaggaagg gcataggaaa attttcccag taaatcccct     4140

gatggtcaca ttaaggtaaa ggttttggct ggtcagtgtg ccaagacctc tccagcttct     4200

cattcatgat gacctctcaa agttgggaaa caagctgatt tcttgccaag aggtctccca     4260

ggagatattt gggaaatgtg aagttcgtat ctttaaggag catttttggt cagcatggtt     4320

gatgaactaa tgatgagaga gttaaggaat gttgctagaa catagggctt gctggtacct     4380

atgtgactaa gaaagggaca tgatgtaagg gaaaaggcct caaattcttg tgaatgtgga     4440

cattctcgtt aatattcttt tgggctaata gtgacatagt gtgcagaggt gtaccaggga     4500

tcatggggga tttcctagca ctagtatgct tctagtttta gataactccc tcctttattc     4560

cctggcccct tgtattttcc ttatcttcct ctttcaagac ccctacccat tttgcctatc     4620

cgtaggctgg ggcttgtgtc tttgtcattg tctggttctt aagagtccca gctccaggtg     4680

gcgtcctccc tgcctctccg tcttgtaatg agttgtagta tttactctta acataggatc     4740

atttggaaca ggagttctga ggaggagaga gtgagggttt tgctattgac tgacttgaac     4800

gatggcttct cctcaagctg taggctccag agcttcctaa cctagtaaaa tgtcaagaac     4860

agacgggaga tattagtgtc tttccctcta tcattaaagg tgttttaacc aaaaaaaaaa     4920

aaaaaaaaaa a                                                          4931


<210>  9
<211>  852
<212>  PRT
<213>  Homo sapiens

<400>  9

Met Leu Ser Gly Lys Lys Ala Ala Ala Ala Ala Ala Ala Ala Ala Ala 
1               5                   10                  15      


Ala Ala Thr Gly Thr Glu Ala Gly Pro Gly Thr Ala Gly Gly Ser Glu 
            20                  25                  30          


Asn Gly Ser Glu Val Ala Ala Gln Pro Ala Gly Leu Ser Gly Pro Ala 
        35                  40                  45              


Glu Val Gly Pro Gly Ala Val Gly Glu Arg Thr Pro Arg Lys Lys Glu 
    50                  55                  60                  


Pro Pro Arg Ala Ser Pro Pro Gly Gly Leu Ala Glu Pro Pro Gly Ser 
65                  70                  75                  80  


Ala Gly Pro Gln Ala Gly Pro Thr Val Val Pro Gly Ser Ala Thr Pro 
                85                  90                  95      


Met Glu Thr Gly Ile Ala Glu Thr Pro Glu Gly Arg Arg Thr Ser Arg 
            100                 105                 110         


Arg Lys Arg Ala Lys Val Glu Tyr Arg Glu Met Asp Glu Ser Leu Ala 
        115                 120                 125             


Asn Leu Ser Glu Asp Glu Tyr Tyr Ser Glu Glu Glu Arg Asn Ala Lys 
    130                 135                 140                 


Ala Glu Lys Glu Lys Lys Leu Pro Pro Pro Pro Pro Gln Ala Pro Pro 
145                 150                 155                 160 


Glu Glu Glu Asn Glu Ser Glu Pro Glu Glu Pro Ser Gly Val Glu Gly 
                165                 170                 175     


Ala Ala Phe Gln Ser Arg Leu Pro His Asp Arg Met Thr Ser Gln Glu 
            180                 185                 190         


Ala Ala Cys Phe Pro Asp Ile Ile Ser Gly Pro Gln Gln Thr Gln Lys 
        195                 200                 205             


Val Phe Leu Phe Ile Arg Asn Arg Thr Leu Gln Leu Trp Leu Asp Asn 
    210                 215                 220                 


Pro Lys Ile Gln Leu Thr Phe Glu Ala Thr Leu Gln Gln Leu Glu Ala 
225                 230                 235                 240 


Pro Tyr Asn Ser Asp Thr Val Leu Val His Arg Val His Ser Tyr Leu 
                245                 250                 255     


Glu Arg His Gly Leu Ile Asn Phe Gly Ile Tyr Lys Arg Ile Lys Pro 
            260                 265                 270         


Leu Pro Thr Lys Lys Thr Gly Lys Val Ile Ile Ile Gly Ser Gly Val 
        275                 280                 285             


Ser Gly Leu Ala Ala Ala Arg Gln Leu Gln Ser Phe Gly Met Asp Val 
    290                 295                 300                 


Thr Leu Leu Glu Ala Arg Asp Arg Val Gly Gly Arg Val Ala Thr Phe 
305                 310                 315                 320 


Arg Lys Gly Asn Tyr Val Ala Asp Leu Gly Ala Met Val Val Thr Gly 
                325                 330                 335     


Leu Gly Gly Asn Pro Met Ala Val Val Ser Lys Gln Val Asn Met Glu 
            340                 345                 350         


Leu Ala Lys Ile Lys Gln Lys Cys Pro Leu Tyr Glu Ala Asn Gly Gln 
        355                 360                 365             


Ala Val Pro Lys Glu Lys Asp Glu Met Val Glu Gln Glu Phe Asn Arg 
    370                 375                 380                 


Leu Leu Glu Ala Thr Ser Tyr Leu Ser His Gln Leu Asp Phe Asn Val 
385                 390                 395                 400 


Leu Asn Asn Lys Pro Val Ser Leu Gly Gln Ala Leu Glu Val Val Ile 
                405                 410                 415     


Gln Leu Gln Glu Lys His Val Lys Asp Glu Gln Ile Glu His Trp Lys 
            420                 425                 430         


Lys Ile Val Lys Thr Gln Glu Glu Leu Lys Glu Leu Leu Asn Lys Met 
        435                 440                 445             


Val Asn Leu Lys Glu Lys Ile Lys Glu Leu His Gln Gln Tyr Lys Glu 
    450                 455                 460                 


Ala Ser Glu Val Lys Pro Pro Arg Asp Ile Thr Ala Glu Phe Leu Val 
465                 470                 475                 480 


Lys Ser Lys His Arg Asp Leu Thr Ala Leu Cys Lys Glu Tyr Asp Glu 
                485                 490                 495     


Leu Ala Glu Thr Gln Gly Lys Leu Glu Glu Lys Leu Gln Glu Leu Glu 
            500                 505                 510         


Ala Asn Pro Pro Ser Asp Val Tyr Leu Ser Ser Arg Asp Arg Gln Ile 
        515                 520                 525             


Leu Asp Trp His Phe Ala Asn Leu Glu Phe Ala Asn Ala Thr Pro Leu 
    530                 535                 540                 


Ser Thr Leu Ser Leu Lys His Trp Asp Gln Asp Asp Asp Phe Glu Phe 
545                 550                 555                 560 


Thr Gly Ser His Leu Thr Val Arg Asn Gly Tyr Ser Cys Val Pro Val 
                565                 570                 575     


Ala Leu Ala Glu Gly Leu Asp Ile Lys Leu Asn Thr Ala Val Arg Gln 
            580                 585                 590         


Val Arg Tyr Thr Ala Ser Gly Cys Glu Val Ile Ala Val Asn Thr Arg 
        595                 600                 605             


Ser Thr Ser Gln Thr Phe Ile Tyr Lys Cys Asp Ala Val Leu Cys Thr 
    610                 615                 620                 


Leu Pro Leu Gly Val Leu Lys Gln Gln Pro Pro Ala Val Gln Phe Val 
625                 630                 635                 640 


Pro Pro Leu Pro Glu Trp Lys Thr Ser Ala Val Gln Arg Met Gly Phe 
                645                 650                 655     


Gly Asn Leu Asn Lys Val Val Leu Cys Phe Asp Arg Val Phe Trp Asp 
            660                 665                 670         


Pro Ser Val Asn Leu Phe Gly His Val Gly Ser Thr Thr Ala Ser Arg 
        675                 680                 685             


Gly Glu Leu Phe Leu Phe Trp Asn Leu Tyr Lys Ala Pro Ile Leu Leu 
    690                 695                 700                 


Ala Leu Val Ala Gly Glu Ala Ala Gly Ile Met Glu Asn Ile Ser Asp 
705                 710                 715                 720 


Asp Val Ile Val Gly Arg Cys Leu Ala Ile Leu Lys Gly Ile Phe Gly 
                725                 730                 735     


Ser Ser Ala Val Pro Gln Pro Lys Glu Thr Val Val Ser Arg Trp Arg 
            740                 745                 750         


Ala Asp Pro Trp Ala Arg Gly Ser Tyr Ser Tyr Val Ala Ala Gly Ser 
        755                 760                 765             


Ser Gly Asn Asp Tyr Asp Leu Met Ala Gln Pro Ile Thr Pro Gly Pro 
    770                 775                 780                 


Ser Ile Pro Gly Ala Pro Gln Pro Ile Pro Arg Leu Phe Phe Ala Gly 
785                 790                 795                 800 


Glu His Thr Ile Arg Asn Tyr Pro Ala Thr Val His Gly Ala Leu Leu 
                805                 810                 815     


Ser Gly Leu Arg Glu Ala Gly Arg Ile Ala Asp Gln Phe Leu Gly Ala 
            820                 825                 830         


Met Tyr Thr Leu Pro Arg Gln Ala Thr Pro Gly Val Pro Ala Gln Gln 
        835                 840                 845             


Ser Pro Ser Met 
    850         


<210>  10
<211>  3053
<212>  DNA
<213>  Homo sapiens

<400>  10
ggcgcggcgg gagcgcgctt ggcgcgtgcg tacgcgacgg cggttggcgg cgcgcgggca       60

gcgtgaagcg aggcgaggca aggcttttcg gacccacgga gcgacagagc gagcggcccc      120

tacggccgtc ggcggcccgg cggcccgaga tgttatctgg gaagaaggcg gcagccgcgg      180

cggcggcggc tgcagcggca gcaaccggga cggaggctgg ccctgggaca gcaggcggct      240

ccgagaacgg gtctgaggtg gccgcgcagc ccgcgggcct gtcgggccca gccgaggtcg      300

ggccgggggc ggtgggggag cgcacacccc gcaagaaaga gcctccgcgg gcctcgcccc      360

ccgggggcct ggcggaaccg ccggggtccg cagggcctca ggccggccct actgtcgtgc      420

ctgggtctgc gacccccatg gaaactggaa tagcagagac tccggagggg cgtcggacca      480

gccggcgcaa gcgggcgaag gtagagtaca gagagatgga tgaaagcttg gccaacctct      540

cagaagatga gtattattca gaagaagaga gaaatgccaa agcagagaag gaaaagaagc      600

ttcccccacc accccctcaa gccccacctg aggaagaaaa tgaaagtgag cctgaagaac      660

catcgggtgt ggagggcgca gctttccaga gccgacttcc tcatgaccgg atgacttctc      720

aagaagcagc ctgttttcca gatattatca gtggaccaca acagacccag aaggtttttc      780

ttttcattag aaaccgcaca ctgcagttgt ggttggataa tccaaagatt cagctgacat      840

ttgaggctac tctccaacaa ttagaagcac cttataacag tgatactgtg cttgtccacc      900

gagttcacag ttatttagag cgtcatggtc ttatcaactt cggcatctat aagaggataa      960

aacccctacc aactaaaaag acaggaaagg taattattat aggctctggg gtctcaggct     1020

tggcagcagc tcgacagtta caaagttttg gaatggatgt cacacttttg gaagccaggg     1080

atcgtgtggg tggacgagtt gccacatttc gcaaaggaaa ctatgtagct gatcttggag     1140

ccatggtggt aacaggtctt ggagggaatc ctatggctgt ggtcagcaaa caagtaaata     1200

tggaactggc caagatcaag caaaaatgcc cactttatga agccaacgga caagctgttc     1260

ctaaagagaa agatgaaatg gtagagcaag agtttaaccg gttgctagaa gctacatctt     1320

accttagtca tcaactagac ttcaatgtcc tcaataataa gcctgtgtcc cttggccagg     1380

cattggaagt tgtcattcag ttacaagaga agcatgtcaa agatgagcag attgaacatt     1440

ggaagaagat agtgaaaact caggaagaat tgaaagaact tcttaataag atggtaaatt     1500

tgaaagagaa aattaaagaa ctccatcagc aatacaaaga agcatctgaa gtaaagccac     1560

ccagagatat tactgccgag ttcttagtga aaagcaaaca cagggatctg accgccctat     1620

gcaaggaata tgatgaatta gctgaaacac aaggaaagct agaagaaaaa cttcaggagt     1680

tggaagcgaa tcccccaagt gatgtatatc tctcatcaag agacagacaa atacttgatt     1740

ggcattttgc aaatcttgaa tttgctaatg ccacacctct ctcaactctc tcccttaagc     1800

actgggatca ggatgatgac tttgagttca ctggcagcca cctgacagta aggaatggct     1860

actcgtgtgt gcctgtggct ttagcagaag gcctagacat taaactgaat acagcagtgc     1920

gacaggttcg ctacacggct tcaggatgtg aagtgatagc tgtgaatacc cgctccacga     1980

gtcaaacctt tatttataaa tgcgacgcag ttctctgtac ccttcccctg ggtgtgctga     2040

agcagcagcc accagccgtt cagtttgtgc cacctctccc tgagtggaaa acatctgcag     2100

tccaaaggat gggatttggc aaccttaaca aggtggtgtt gtgttttgat cgggtgttct     2160

gggatccaag tgtcaatttg ttcgggcatg ttggcagtac gactgccagc aggggtgagc     2220

tcttcctctt ctggaacctc tataaagctc caatactgtt ggcactagtg gcaggagaag     2280

ctgctggtat catggaaaac ataagtgacg atgtgattgt tggccgatgc ctggccattc     2340

tcaaagggat ttttggtagc agtgcagtac ctcagcccaa agaaactgtg gtgtctcgtt     2400

ggcgtgctga tccctgggct cggggctctt attcctatgt tgctgcagga tcatctggaa     2460

atgactatga tttaatggct cagccaatca ctcctggccc ctcgattcca ggtgccccac     2520

agccgattcc acgactcttc tttgcgggag aacatacgat ccgtaactac ccagccacag     2580

tgcatggtgc tctgctgagt gggctgcgag aagcgggaag aattgcagac cagtttttgg     2640

gggccatgta tacgctgcct cgccaggcca caccaggtgt tcctgcacag cagtccccaa     2700

gcatgtgaga cagatgcatt ctaagggaag aggcccatgt gcctgtttct gccatgtaag     2760

gaaggctctt ctagcaatac tagatcccac tgagaaaatc caccctggca tctgggctcc     2820

tgatcagctg atggagctcc tgatttgaca aaggagcttg cctcctttga atgacctaga     2880

gcacagggag gaacttgtcc attagtttgg aattgtgttc ttcgtaaaga ctgaggcaag     2940

caagtgctgt gaaataacat catcttagtc ccttggtgtg tggggttttt gttttttttt     3000

tatattttga gaataaaact tcatataaaa ttggcaaaaa aaaaaaaaaa aaa            3053


<210>  11
<211>  876
<212>  PRT
<213>  Homo sapiens

<400>  11

Met Leu Ser Gly Lys Lys Ala Ala Ala Ala Ala Ala Ala Ala Ala Ala 
1               5                   10                  15      


Ala Ala Thr Gly Thr Glu Ala Gly Pro Gly Thr Ala Gly Gly Ser Glu 
            20                  25                  30          


Asn Gly Ser Glu Val Ala Ala Gln Pro Ala Gly Leu Ser Gly Pro Ala 
        35                  40                  45              


Glu Val Gly Pro Gly Ala Val Gly Glu Arg Thr Pro Arg Lys Lys Glu 
    50                  55                  60                  


Pro Pro Arg Ala Ser Pro Pro Gly Gly Leu Ala Glu Pro Pro Gly Ser 
65                  70                  75                  80  


Ala Gly Pro Gln Ala Gly Pro Thr Val Val Pro Gly Ser Ala Thr Pro 
                85                  90                  95      


Met Glu Thr Gly Ile Ala Glu Thr Pro Glu Gly Arg Arg Thr Ser Arg 
            100                 105                 110         


Arg Lys Arg Ala Lys Val Glu Tyr Arg Glu Met Asp Glu Ser Leu Ala 
        115                 120                 125             


Asn Leu Ser Glu Asp Glu Tyr Tyr Ser Glu Glu Glu Arg Asn Ala Lys 
    130                 135                 140                 


Ala Glu Lys Glu Lys Lys Leu Pro Pro Pro Pro Pro Gln Ala Pro Pro 
145                 150                 155                 160 


Glu Glu Glu Asn Glu Ser Glu Pro Glu Glu Pro Ser Gly Gln Ala Gly 
                165                 170                 175     


Gly Leu Gln Asp Asp Ser Ser Gly Gly Tyr Gly Asp Gly Gln Ala Ser 
            180                 185                 190         


Gly Val Glu Gly Ala Ala Phe Gln Ser Arg Leu Pro His Asp Arg Met 
        195                 200                 205             


Thr Ser Gln Glu Ala Ala Cys Phe Pro Asp Ile Ile Ser Gly Pro Gln 
    210                 215                 220                 


Gln Thr Gln Lys Val Phe Leu Phe Ile Arg Asn Arg Thr Leu Gln Leu 
225                 230                 235                 240 


Trp Leu Asp Asn Pro Lys Ile Gln Leu Thr Phe Glu Ala Thr Leu Gln 
                245                 250                 255     


Gln Leu Glu Ala Pro Tyr Asn Ser Asp Thr Val Leu Val His Arg Val 
            260                 265                 270         


His Ser Tyr Leu Glu Arg His Gly Leu Ile Asn Phe Gly Ile Tyr Lys 
        275                 280                 285             


Arg Ile Lys Pro Leu Pro Thr Lys Lys Thr Gly Lys Val Ile Ile Ile 
    290                 295                 300                 


Gly Ser Gly Val Ser Gly Leu Ala Ala Ala Arg Gln Leu Gln Ser Phe 
305                 310                 315                 320 


Gly Met Asp Val Thr Leu Leu Glu Ala Arg Asp Arg Val Gly Gly Arg 
                325                 330                 335     


Val Ala Thr Phe Arg Lys Gly Asn Tyr Val Ala Asp Leu Gly Ala Met 
            340                 345                 350         


Val Val Thr Gly Leu Gly Gly Asn Pro Met Ala Val Val Ser Lys Gln 
        355                 360                 365             


Val Asn Met Glu Leu Ala Lys Ile Lys Gln Lys Cys Pro Leu Tyr Glu 
    370                 375                 380                 


Ala Asn Gly Gln Ala Asp Thr Val Lys Val Pro Lys Glu Lys Asp Glu 
385                 390                 395                 400 


Met Val Glu Gln Glu Phe Asn Arg Leu Leu Glu Ala Thr Ser Tyr Leu 
                405                 410                 415     


Ser His Gln Leu Asp Phe Asn Val Leu Asn Asn Lys Pro Val Ser Leu 
            420                 425                 430         


Gly Gln Ala Leu Glu Val Val Ile Gln Leu Gln Glu Lys His Val Lys 
        435                 440                 445             


Asp Glu Gln Ile Glu His Trp Lys Lys Ile Val Lys Thr Gln Glu Glu 
    450                 455                 460                 


Leu Lys Glu Leu Leu Asn Lys Met Val Asn Leu Lys Glu Lys Ile Lys 
465                 470                 475                 480 


Glu Leu His Gln Gln Tyr Lys Glu Ala Ser Glu Val Lys Pro Pro Arg 
                485                 490                 495     


Asp Ile Thr Ala Glu Phe Leu Val Lys Ser Lys His Arg Asp Leu Thr 
            500                 505                 510         


Ala Leu Cys Lys Glu Tyr Asp Glu Leu Ala Glu Thr Gln Gly Lys Leu 
        515                 520                 525             


Glu Glu Lys Leu Gln Glu Leu Glu Ala Asn Pro Pro Ser Asp Val Tyr 
    530                 535                 540                 


Leu Ser Ser Arg Asp Arg Gln Ile Leu Asp Trp His Phe Ala Asn Leu 
545                 550                 555                 560 


Glu Phe Ala Asn Ala Thr Pro Leu Ser Thr Leu Ser Leu Lys His Trp 
                565                 570                 575     


Asp Gln Asp Asp Asp Phe Glu Phe Thr Gly Ser His Leu Thr Val Arg 
            580                 585                 590         


Asn Gly Tyr Ser Cys Val Pro Val Ala Leu Ala Glu Gly Leu Asp Ile 
        595                 600                 605             


Lys Leu Asn Thr Ala Val Arg Gln Val Arg Tyr Thr Ala Ser Gly Cys 
    610                 615                 620                 


Glu Val Ile Ala Val Asn Thr Arg Ser Thr Ser Gln Thr Phe Ile Tyr 
625                 630                 635                 640 


Lys Cys Asp Ala Val Leu Cys Thr Leu Pro Leu Gly Val Leu Lys Gln 
                645                 650                 655     


Gln Pro Pro Ala Val Gln Phe Val Pro Pro Leu Pro Glu Trp Lys Thr 
            660                 665                 670         


Ser Ala Val Gln Arg Met Gly Phe Gly Asn Leu Asn Lys Val Val Leu 
        675                 680                 685             


Cys Phe Asp Arg Val Phe Trp Asp Pro Ser Val Asn Leu Phe Gly His 
    690                 695                 700                 


Val Gly Ser Thr Thr Ala Ser Arg Gly Glu Leu Phe Leu Phe Trp Asn 
705                 710                 715                 720 


Leu Tyr Lys Ala Pro Ile Leu Leu Ala Leu Val Ala Gly Glu Ala Ala 
                725                 730                 735     


Gly Ile Met Glu Asn Ile Ser Asp Asp Val Ile Val Gly Arg Cys Leu 
            740                 745                 750         


Ala Ile Leu Lys Gly Ile Phe Gly Ser Ser Ala Val Pro Gln Pro Lys 
        755                 760                 765             


Glu Thr Val Val Ser Arg Trp Arg Ala Asp Pro Trp Ala Arg Gly Ser 
    770                 775                 780                 


Tyr Ser Tyr Val Ala Ala Gly Ser Ser Gly Asn Asp Tyr Asp Leu Met 
785                 790                 795                 800 


Ala Gln Pro Ile Thr Pro Gly Pro Ser Ile Pro Gly Ala Pro Gln Pro 
                805                 810                 815     


Ile Pro Arg Leu Phe Phe Ala Gly Glu His Thr Ile Arg Asn Tyr Pro 
            820                 825                 830         


Ala Thr Val His Gly Ala Leu Leu Ser Gly Leu Arg Glu Ala Gly Arg 
        835                 840                 845             


Ile Ala Asp Gln Phe Leu Gly Ala Met Tyr Thr Leu Pro Arg Gln Ala 
    850                 855                 860                 


Thr Pro Gly Val Pro Ala Gln Gln Ser Pro Ser Met 
865                 870                 875     


<210>  12
<211>  3125
<212>  DNA
<213>  Homo sapiens

<400>  12
ggcgcggcgg gagcgcgctt ggcgcgtgcg tacgcgacgg cggttggcgg cgcgcgggca       60

gcgtgaagcg aggcgaggca aggcttttcg gacccacgga gcgacagagc gagcggcccc      120

tacggccgtc ggcggcccgg cggcccgaga tgttatctgg gaagaaggcg gcagccgcgg      180

cggcggcggc tgcagcggca gcaaccggga cggaggctgg ccctgggaca gcaggcggct      240

ccgagaacgg gtctgaggtg gccgcgcagc ccgcgggcct gtcgggccca gccgaggtcg      300

ggccgggggc ggtgggggag cgcacacccc gcaagaaaga gcctccgcgg gcctcgcccc      360

ccgggggcct ggcggaaccg ccggggtccg cagggcctca ggccggccct actgtcgtgc      420

ctgggtctgc gacccccatg gaaactggaa tagcagagac tccggagggg cgtcggacca      480

gccggcgcaa gcgggcgaag gtagagtaca gagagatgga tgaaagcttg gccaacctct      540

cagaagatga gtattattca gaagaagaga gaaatgccaa agcagagaag gaaaagaagc      600

ttcccccacc accccctcaa gccccacctg aggaagaaaa tgaaagtgag cctgaagaac      660

catcggggca agcaggagga cttcaagacg acagttctgg agggtatgga gacggccaag      720

catcaggtgt ggagggcgca gctttccaga gccgacttcc tcatgaccgg atgacttctc      780

aagaagcagc ctgttttcca gatattatca gtggaccaca acagacccag aaggtttttc      840

ttttcattag aaaccgcaca ctgcagttgt ggttggataa tccaaagatt cagctgacat      900

ttgaggctac tctccaacaa ttagaagcac cttataacag tgatactgtg cttgtccacc      960

gagttcacag ttatttagag cgtcatggtc ttatcaactt cggcatctat aagaggataa     1020

aacccctacc aactaaaaag acaggaaagg taattattat aggctctggg gtctcaggct     1080

tggcagcagc tcgacagtta caaagttttg gaatggatgt cacacttttg gaagccaggg     1140

atcgtgtggg tggacgagtt gccacatttc gcaaaggaaa ctatgtagct gatcttggag     1200

ccatggtggt aacaggtctt ggagggaatc ctatggctgt ggtcagcaaa caagtaaata     1260

tggaactggc caagatcaag caaaaatgcc cactttatga agccaacgga caagctgaca     1320

ctgtcaaggt tcctaaagag aaagatgaaa tggtagagca agagtttaac cggttgctag     1380

aagctacatc ttaccttagt catcaactag acttcaatgt cctcaataat aagcctgtgt     1440

cccttggcca ggcattggaa gttgtcattc agttacaaga gaagcatgtc aaagatgagc     1500

agattgaaca ttggaagaag atagtgaaaa ctcaggaaga attgaaagaa cttcttaata     1560

agatggtaaa tttgaaagag aaaattaaag aactccatca gcaatacaaa gaagcatctg     1620

aagtaaagcc acccagagat attactgccg agttcttagt gaaaagcaaa cacagggatc     1680

tgaccgccct atgcaaggaa tatgatgaat tagctgaaac acaaggaaag ctagaagaaa     1740

aacttcagga gttggaagcg aatcccccaa gtgatgtata tctctcatca agagacagac     1800

aaatacttga ttggcatttt gcaaatcttg aatttgctaa tgccacacct ctctcaactc     1860

tctcccttaa gcactgggat caggatgatg actttgagtt cactggcagc cacctgacag     1920

taaggaatgg ctactcgtgt gtgcctgtgg ctttagcaga aggcctagac attaaactga     1980

atacagcagt gcgacaggtt cgctacacgg cttcaggatg tgaagtgata gctgtgaata     2040

cccgctccac gagtcaaacc tttatttata aatgcgacgc agttctctgt acccttcccc     2100

tgggtgtgct gaagcagcag ccaccagccg ttcagtttgt gccacctctc cctgagtgga     2160

aaacatctgc agtccaaagg atgggatttg gcaaccttaa caaggtggtg ttgtgttttg     2220

atcgggtgtt ctgggatcca agtgtcaatt tgttcgggca tgttggcagt acgactgcca     2280

gcaggggtga gctcttcctc ttctggaacc tctataaagc tccaatactg ttggcactag     2340

tggcaggaga agctgctggt atcatggaaa acataagtga cgatgtgatt gttggccgat     2400

gcctggccat tctcaaaggg atttttggta gcagtgcagt acctcagccc aaagaaactg     2460

tggtgtctcg ttggcgtgct gatccctggg ctcggggctc ttattcctat gttgctgcag     2520

gatcatctgg aaatgactat gatttaatgg ctcagccaat cactcctggc ccctcgattc     2580

caggtgcccc acagccgatt ccacgactct tctttgcggg agaacatacg atccgtaact     2640

acccagccac agtgcatggt gctctgctga gtgggctgcg agaagcggga agaattgcag     2700

accagttttt gggggccatg tatacgctgc ctcgccaggc cacaccaggt gttcctgcac     2760

agcagtcccc aagcatgtga gacagatgca ttctaaggga agaggcccat gtgcctgttt     2820

ctgccatgta aggaaggctc ttctagcaat actagatccc actgagaaaa tccaccctgg     2880

catctgggct cctgatcagc tgatggagct cctgatttga caaaggagct tgcctccttt     2940

gaatgaccta gagcacaggg aggaacttgt ccattagttt ggaattgtgt tcttcgtaaa     3000

gactgaggca agcaagtgct gtgaaataac atcatcttag tcccttggtg tgtggggttt     3060

ttgttttttt tttatatttt gagaataaaa cttcatataa aattggcaaa aaaaaaaaaa     3120

aaaaa                                                                 3125


<210>  13
<211>  523
<212>  PRT
<213>  Homo sapiens

<400>  13

Met Pro Ser Val Met Glu Lys Pro Ser Ala Gly Ser Gly Ile Leu Ser 
1               5                   10                  15      


Arg Ser Arg Ala Lys Thr Val Pro Asn Gly Gly Gln Pro His Ser Glu 
            20                  25                  30          


Asp Asp Ser Ser Glu Glu Glu His Ser His Asp Ser Met Ile Arg Val 
        35                  40                  45              


Gly Thr Asn Tyr Gln Ala Val Ile Pro Glu Cys Lys Pro Glu Ser Pro 
    50                  55                  60                  


Ala Arg Tyr Ser Asn Lys Glu Leu Lys Gly Met Leu Val Trp Ser Pro 
65                  70                  75                  80  


Asn His Cys Val Ser Asp Ala Lys Leu Asp Lys Tyr Ile Ala Met Ala 
                85                  90                  95      


Lys Glu Lys His Gly Tyr Asn Ile Glu Gln Ala Leu Gly Met Leu Leu 
            100                 105                 110         


Trp His Lys His Asp Val Glu Lys Ser Leu Ala Asp Leu Ala Asn Phe 
        115                 120                 125             


Thr Pro Phe Pro Asp Glu Trp Thr Val Glu Asp Lys Val Leu Phe Glu 
    130                 135                 140                 


Gln Ala Phe Gly Phe His Gly Lys Cys Phe Gln Arg Ile Gln Gln Met 
145                 150                 155                 160 


Leu Pro Asp Lys Leu Ile Pro Ser Leu Val Lys Tyr Tyr Tyr Ser Trp 
                165                 170                 175     


Lys Lys Thr Arg Ser Arg Thr Ser Val Met Asp Arg Gln Ala Arg Arg 
            180                 185                 190         


Leu Gly Gly Arg Lys Asp Lys Glu Asp Ser Asp Glu Leu Glu Glu Gly 
        195                 200                 205             


Arg Gly Gly Val Ser Glu Gly Glu Pro Asp Pro Ala Asp Pro Lys Arg 
    210                 215                 220                 


Glu Pro Leu Pro Ser Arg Pro Leu Asn Ala Arg Pro Gly Pro Gly Lys 
225                 230                 235                 240 


Lys Glu Val Gln Val Ser Gln Tyr Arg His His Pro Leu Arg Thr Arg 
                245                 250                 255     


Arg Arg Pro Pro Lys Gly Met Tyr Leu Ser Pro Glu Gly Leu Thr Ala 
            260                 265                 270         


Val Ser Gly Ser Pro Asp Leu Ala Asn Leu Thr Leu Arg Gly Leu Asp 
        275                 280                 285             


Ser Gln Leu Ile Ser Leu Lys Arg Gln Val Gln Ser Met Lys Gln Thr 
    290                 295                 300                 


Asn Ser Ser Leu Arg Gln Ala Leu Glu Gly Gly Ile Asp Pro Leu Arg 
305                 310                 315                 320 


Pro Pro Glu Ala Asn Thr Lys Phe Asn Ser Arg Trp Thr Thr Asp Glu 
                325                 330                 335     


Gln Leu Leu Ala Val Gln Ala Ile Arg Arg Tyr Gly Lys Asp Phe Gly 
            340                 345                 350         


Ala Ile Ala Glu Val Ile Gly Asn Lys Thr Leu Thr Gln Val Lys Thr 
        355                 360                 365             


Phe Phe Val Ser Tyr Arg Arg Arg Phe Asn Leu Glu Glu Val Leu Gln 
    370                 375                 380                 


Glu Trp Glu Ala Glu Gln Asp Gly Ala Pro Gly Ala Pro Val Pro Met 
385                 390                 395                 400 


Glu Glu Ala Arg Arg Gly Ala Pro Leu Pro Ala Pro Ala Leu Glu Glu 
                405                 410                 415     


Asp Asp Glu Val Gln Ile Thr Ser Val Ser Thr Ser Val Pro Arg Ser 
            420                 425                 430         


Val Pro Pro Ala Pro Pro Pro Pro Pro Pro Pro Thr Ser Leu Ser Gln 
        435                 440                 445             


Pro Pro Pro Leu Leu Arg Pro Pro Leu Pro Thr Ala Pro Thr Leu Leu 
    450                 455                 460                 


Arg Gln Pro Pro Pro Leu Gln Gln Gly Arg Phe Leu Gln Pro Arg Leu 
465                 470                 475                 480 


Ala Pro Asn Gln Pro Pro Pro Pro Leu Ile Arg Pro Ala Leu Ala Ala 
                485                 490                 495     


Pro Arg His Ser Ala Arg Pro Gly Pro Gln Pro Pro Pro Thr Leu Ile 
            500                 505                 510         


Gly Thr Pro Leu Glu Pro Pro Ala Pro Ser Leu 
        515                 520             


<210>  14
<211>  2621
<212>  DNA
<213>  Homo sapiens

<400>  14
gcgcccagcc gctgaacggc gtgggcaggt gggcggtggg gttccagggc gccccgagga       60

cagggggccc cgacttcagg ggaaccccaa ccctgagggg cgtacatagt aatcacgccc      120

cagccgcacc ggaccttgcg ctcatccctt gcgtccccca cttctgcaca aacttttctg      180

acgccctggc tcgtgggggt cgtggagagc gctggggcta ccaggtgggc tcccaccccg      240

ccggacccta gccacgctga cctcctgcct ctcctaacct cagtggcgac ctctccaggc      300

cgggccgggc tcggcactcg gagcgagtgc ggcaaccact gtcgctctcc gaaggctcct      360

gcgccccccg gggcagctgg gcggggtaat gccctcagtg atggagaagc cgagcgcggg      420

ctctgggatc ctgtcccgta gccgggccaa gacggtgccc aacggcggac agccccactc      480

ggaggatgac agcagcgagg aggagcactc gcacgacagc atgatccgcg ttggaaccaa      540

ttaccaggcc gtaattccgg agtgcaagcc tgagagcccc gcacgctaca gcaacaagga      600

gctgaagggg atgctggtgt ggtcacccaa ccactgtgtg tcagatgcca agcttgacaa      660

gtacattgcg atggccaagg agaagcatgg ctacaacatt gagcaggcgc tgggcatgct      720

tctgtggcat aagcacgatg tggagaagtc gctggccgac ctggccaact tcaccccatt      780

ccctgacgag tggacagtag aggacaaggt gctgtttgaa caggcctttg gcttccatgg      840

caaatgcttc cagcggatcc agcagatgct gcctgacaag ttgattccca gcctggtgaa      900

atactactac tcttggaaga agacccgcag ccgaactagt gtgatggaca gacaggcccg      960

gcggctgggg ggccgcaagg acaaagaaga cagtgatgag ctcgaagagg gtcgaggagg     1020

cgtgagtgag ggagagcccg atcctgcaga tcccaagaga gagcctctac cctctcggcc     1080

cctgaatgca cgcccaggcc ctgggaaaaa ggaggtccag gtgtctcagt accgccacca     1140

tcccttgcga acccggcgtc gcccacccaa gggcatgtac ctgagccctg aaggcctcac     1200

ggcagtgtca ggaagcccgg accttgccaa cctcacgctc cgaggtcttg actctcagct     1260

catctccctc aagcgccagg tacagagcat gaagcagacg aacagcagcc tgcgccaagc     1320

cctggagggc ggtattgatc cactacgccc cccggaggcc aacaccaagt tcaactcccg     1380

ctggaccaca gatgagcagc ttttggctgt tcaagccatc cgtaggtatg gcaaagactt     1440

tggggctatt gcagaggtga ttgggaacaa gactctgacc caggtgaaga ctttctttgt     1500

gagctaccgg cgccgcttca atctggagga ggtgctgcag gaatgggagg ctgagcagga     1560

tggggcccct ggagccccag tccccatgga ggaggctagg agaggggctc cattgccagc     1620

cccagcccta gaggaagatg atgaggtcca gattacatcg gtctccacgt ccgtgccccg     1680

atcagtgccc cctgcgccac caccccctcc acctcccacc tcgctgtccc agccaccccc     1740

gctgctgagg ccacctttgc ccacggctcc cactctgctc cgacagccac ccccactgca     1800

gcagggccgc ttcctccagc cccggctggc ccccaaccag cccccaccgc ctctcatccg     1860

ccccgctctg gctgcccccc gccacagcgc ccgccctggc cctcagcccc cacccaccct     1920

gattggaacc cctctggagc ccccagcacc ctcactctga gccctgacgt cctccaccaa     1980

ccacgggctc caggacccct ttgctggcca tccccaggca tctctggtgt cactgaggac     2040

agaagggact agggctctgg cggggtcttt gtaagaccag agtttcggac agcccagccc     2100

cgccctttgg gttctgcatg tgttcctggc agctgggcct gtctcctggg gccatggccg     2160

ggctcagggg cctttgagct ggcctgaggg cactttcgct tcctggccgg tactggaatg     2220

gctgtgtcct agtctgctgg ggcttggcct ctgggtcctg ccctttgtgt gtccggggta     2280

gtgaccttag cgtggagtgg ggagagggca gttgggtgtg ctggctgttc tcattcctct     2340

ttcccttctt ttagcaataa gtctggggtg aggtggggag ggaggctgca gggggggagg     2400

tgggcagagg ggccttacag cagcagaggc tggaagagaa gctctgtctt caggggccag     2460

ctgggaaatg ctaaggagct gagggtgccc accaagccca ccttccagaa acttggagaa     2520

atgggggttg ggaacttatg cagacatgga tttatttttc aacatttttt aaaaattaaa     2580

aaaaataaaa tctaagctta ctgaaaaaaa aaaaaaaaaa a                         2621


