                         SEQUENCE LISTING

<110>  THE UNITED STATES OF AMERICA, AS REPRESENTED BY THE 
       SECRETARY, DEPARTMENT OF HEALTH AND HUMAN SERVICES
 
<120>  CYTOLETHAL DISTENDING TOXIN SUBUNIT B CONJUGATED OR FUSED TO 
       BACILLUS ANTHRACIS TOXIN LETHAL FACTOR

<130>  718053

<150>  US 61/837,428
<151>  2013-06-20

<160>  17    

<170>  PatentIn version 3.5

<210>  1
<211>  261
<212>  PRT
<213>  Haemophilus ducreyi

<400>  1

Asn Leu Ser Asp Phe Lys Val Ala Thr Trp Asn Leu Gln Gly Ser Ser 
1               5                   10                  15      


Ala Val Asn Glu Ser Lys Trp Asn Ile Asn Val Arg Gln Leu Leu Ser 
            20                  25                  30          


Gly Glu Gln Gly Ala Asp Ile Leu Met Val Gln Glu Ala Gly Ser Leu 
        35                  40                  45              


Pro Ser Ser Ala Val Arg Thr Ser Arg Val Ile Gln His Gly Gly Thr 
    50                  55                  60                  


Pro Ile Glu Glu Tyr Thr Trp Asn Leu Gly Thr Arg Ser Arg Pro Asn 
65                  70                  75                  80  


Met Val Tyr Ile Tyr Tyr Ser Arg Leu Asp Val Gly Ala Asn Arg Val 
                85                  90                  95      


Asn Leu Ala Ile Val Ser Arg Arg Gln Ala Asp Glu Ala Phe Ile Val 
            100                 105                 110         


His Ser Asp Ser Ser Val Leu Gln Ser Arg Pro Ala Val Gly Ile Arg 
        115                 120                 125             


Ile Gly Thr Asp Val Phe Phe Thr Val His Ala Leu Ala Thr Gly Gly 
    130                 135                 140                 


Ser Asp Ala Val Ser Leu Ile Arg Asn Ile Phe Thr Thr Phe Asn Ser 
145                 150                 155                 160 


Ser Ser Ser Pro Pro Glu Arg Arg Val Tyr Ser Trp Met Val Val Gly 
                165                 170                 175     


Asp Phe Asn Arg Ala Pro Ala Asn Leu Glu Val Ala Leu Arg Gln Glu 
            180                 185                 190         


Pro Ala Val Ser Glu Asn Thr Ile Ile Ile Ala Pro Thr Glu Pro Thr 
        195                 200                 205             


His Arg Ser Gly Asn Ile Leu Asp Tyr Ala Ile Leu His Asp Ala His 
    210                 215                 220                 


Leu Pro Arg Arg Glu Gln Ala Arg Glu Arg Ile Gly Ala Ser Leu Met 
225                 230                 235                 240 


Leu Asn Gln Leu Arg Ser Gln Ile Thr Ser Asp His Phe Pro Val Ser 
                245                 250                 255     


Phe Val Arg Asp Arg 
            260     


<210>  2
<211>  255
<212>  PRT
<213>  Bacillus anthracis

<400>  2

Ala Gly Gly His Gly Asp Val Gly Met His Val Lys Glu Lys Glu Lys 
1               5                   10                  15      


Asn Lys Asp Glu Asn Lys Arg Lys Asp Glu Glu Arg Asn Lys Thr Gln 
            20                  25                  30          


Glu Glu His Leu Lys Glu Ile Met Lys His Ile Val Lys Ile Glu Val 
        35                  40                  45              


Lys Gly Glu Glu Ala Val Lys Lys Glu Ala Ala Glu Lys Leu Leu Glu 
    50                  55                  60                  


Lys Val Pro Ser Asp Val Leu Glu Met Tyr Lys Ala Ile Gly Gly Lys 
65                  70                  75                  80  


Ile Tyr Ile Val Asp Gly Asp Ile Thr Lys His Ile Ser Leu Glu Ala 
                85                  90                  95      


Leu Ser Glu Asp Lys Lys Lys Ile Lys Asp Ile Tyr Gly Lys Asp Ala 
            100                 105                 110         


Leu Leu His Glu His Tyr Val Tyr Ala Lys Glu Gly Tyr Glu Pro Val 
        115                 120                 125             


Leu Val Ile Gln Ser Ser Glu Asp Tyr Val Glu Asn Thr Glu Lys Ala 
    130                 135                 140                 


Leu Asn Val Tyr Tyr Glu Ile Gly Lys Ile Leu Ser Arg Asp Ile Leu 
145                 150                 155                 160 


Ser Lys Ile Asn Gln Pro Tyr Gln Lys Phe Leu Asp Val Leu Asn Thr 
                165                 170                 175     


Ile Lys Asn Ala Ser Asp Ser Asp Gly Gln Asp Leu Leu Phe Thr Asn 
            180                 185                 190         


Gln Leu Lys Glu His Pro Thr Asp Phe Ser Val Glu Phe Leu Glu Gln 
        195                 200                 205             


Asn Ser Asn Glu Val Gln Glu Val Phe Ala Lys Ala Phe Ala Tyr Tyr 
    210                 215                 220                 


Ile Glu Pro Gln His Arg Asp Val Leu Gln Leu Tyr Ala Pro Glu Ala 
225                 230                 235                 240 


Phe Asn Tyr Met Asp Lys Phe Asn Glu Gln Glu Ile Asn Leu Ser 
                245                 250                 255 


<210>  3
<211>  527
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic

<400>  3

Ala Gly Gly His Gly Asp Val Gly Met His Val Lys Glu Lys Glu Lys 
1               5                   10                  15      


Asn Lys Asp Glu Asn Lys Arg Lys Asp Glu Glu Arg Asn Lys Thr Gln 
            20                  25                  30          


Glu Glu His Leu Lys Glu Ile Met Lys His Ile Val Lys Ile Glu Val 
        35                  40                  45              


Lys Gly Glu Glu Ala Val Lys Lys Glu Ala Ala Glu Lys Leu Leu Glu 
    50                  55                  60                  


Lys Val Pro Ser Asp Val Leu Glu Met Tyr Lys Ala Ile Gly Gly Lys 
65                  70                  75                  80  


Ile Tyr Ile Val Asp Gly Asp Ile Thr Lys His Ile Ser Leu Glu Ala 
                85                  90                  95      


Leu Ser Glu Asp Lys Lys Lys Ile Lys Asp Ile Tyr Gly Lys Asp Ala 
            100                 105                 110         


Leu Leu His Glu His Tyr Val Tyr Ala Lys Glu Gly Tyr Glu Pro Val 
        115                 120                 125             


Leu Val Ile Gln Ser Ser Glu Asp Tyr Val Glu Asn Thr Glu Lys Ala 
    130                 135                 140                 


Leu Asn Val Tyr Tyr Glu Ile Gly Lys Ile Leu Ser Arg Asp Ile Leu 
145                 150                 155                 160 


Ser Lys Ile Asn Gln Pro Tyr Gln Lys Phe Leu Asp Val Leu Asn Thr 
                165                 170                 175     


Ile Lys Asn Ala Ser Asp Ser Asp Gly Gln Asp Leu Leu Phe Thr Asn 
            180                 185                 190         


Gln Leu Lys Glu His Pro Thr Asp Phe Ser Val Glu Phe Leu Glu Gln 
        195                 200                 205             


Asn Ser Asn Glu Val Gln Glu Val Phe Ala Lys Ala Phe Ala Tyr Tyr 
    210                 215                 220                 


Ile Glu Pro Gln His Arg Asp Val Leu Gln Leu Tyr Ala Pro Glu Ala 
225                 230                 235                 240 


Phe Asn Tyr Met Asp Lys Phe Asn Glu Gln Glu Ile Asn Leu Ser Thr 
                245                 250                 255     


Arg Ser Gly Glu Asn Leu Tyr Phe Gln Ser Asn Leu Ser Asp Phe Lys 
            260                 265                 270         


Val Ala Thr Trp Asn Leu Gln Gly Ser Ser Ala Val Asn Glu Ser Lys 
        275                 280                 285             


Trp Asn Ile Asn Val Arg Gln Leu Leu Ser Gly Glu Gln Gly Ala Asp 
    290                 295                 300                 


Ile Leu Met Val Gln Glu Ala Gly Ser Leu Pro Ser Ser Ala Val Arg 
305                 310                 315                 320 


Thr Ser Arg Val Ile Gln His Gly Gly Thr Pro Ile Glu Glu Tyr Thr 
                325                 330                 335     


Trp Asn Leu Gly Thr Arg Ser Arg Pro Asn Met Val Tyr Ile Tyr Tyr 
            340                 345                 350         


Ser Arg Leu Asp Val Gly Ala Asn Arg Val Asn Leu Ala Ile Val Ser 
        355                 360                 365             


Arg Arg Gln Ala Asp Glu Ala Phe Ile Val His Ser Asp Ser Ser Val 
    370                 375                 380                 


Leu Gln Ser Arg Pro Ala Val Gly Ile Arg Ile Gly Thr Asp Val Phe 
385                 390                 395                 400 


Phe Thr Val His Ala Leu Ala Thr Gly Gly Ser Asp Ala Val Ser Leu 
                405                 410                 415     


Ile Arg Asn Ile Phe Thr Thr Phe Asn Ser Ser Ser Ser Pro Pro Glu 
            420                 425                 430         


Arg Arg Val Tyr Ser Trp Met Val Val Gly Asp Phe Asn Arg Ala Pro 
        435                 440                 445             


Ala Asn Leu Glu Val Ala Leu Arg Gln Glu Pro Ala Val Ser Glu Asn 
    450                 455                 460                 


Thr Ile Ile Ile Ala Pro Thr Glu Pro Thr His Arg Ser Gly Asn Ile 
465                 470                 475                 480 


Leu Asp Tyr Ala Ile Leu His Asp Ala His Leu Pro Arg Arg Glu Gln 
                485                 490                 495     


Ala Arg Glu Arg Ile Gly Ala Ser Leu Met Leu Asn Gln Leu Arg Ser 
            500                 505                 510         


Gln Ile Thr Ser Asp His Phe Pro Val Ser Phe Val Arg Asp Arg 
        515                 520                 525         


<210>  4
<211>  11
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic

<400>  4

Thr Arg Ser Gly Glu Asn Leu Tyr Phe Gln Ser 
1               5                   10      


<210>  5
<211>  29
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic

<400>  5

Met Lys Lys Arg Lys Val Leu Ile Pro Leu Met Ala Leu Ser Thr Ile 
1               5                   10                  15      


Leu Val Ser Ser Thr Gly Asn Leu Glu Val Ile Gln Ala 
            20                  25                  


<210>  6
<211>  87
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic

<400>  6
atgaaaaaac gaaaagtgtt aataccatta atggcattgt ctacgatatt agtttcaagc       60

acaggtaatt tagaggtgat tcaggca                                           87


<210>  7
<211>  765
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic

<400>  7
gcgggcggtc atggtgatgt aggtatgcac gtaaaagaga aagagaaaaa taaagatgag       60

aataagagaa aagatgaaga acgaaataaa acacaggaag agcatttaaa ggaaatcatg      120

aaacacattg taaaaataga agtaaaaggg gaggaagctg ttaaaaaaga ggcagcagaa      180

aagctacttg agaaagtacc atctgatgtt ttagagatgt ataaagcaat tggaggaaag      240

atatatattg tggatggtga tattacaaaa catatatctt tagaagcatt atctgaagat      300

aagaaaaaaa taaaagacat ttatgggaaa gatgctttat tacatgaaca ttatgtatat      360

gcaaaagaag gatatgaacc cgtacttgta atccaatctt cggaagatta tgtagaaaat      420

actgaaaagg cactgaacgt ttattatgaa ataggtaaga tattatcaag ggatatttta      480

agtaaaatta atcaaccata tcagaaattt ttagatgtat taaataccat taaaaatgca      540

tctgattcag atggacaaga tcttttattt actaatcagc ttaaggaaca tcccacagac      600

ttttctgtag aattcttgga acaaaatagc aatgaggtac aagaagtatt tgcgaaagct      660

tttgcatatt atatcgagcc acagcatcgt gatgttttac agctttatgc accggaagct      720

tttaattaca tggataaatt taacgaacaa gaaataaatc tatcc                      765


<210>  8
<211>  783
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic

<400>  8
aacttgagtg acttcaaagt agcaacttgg aatctgcaag gttcttcagc agtaaatgaa       60

agtaaatgga atattaatgt gcgccaatta ttatcgggag aacaaggtgc agatattttg      120

atggtacaag aagcgggttc cttaccaagt tcggcagtaa gaacctcacg ggtaattcaa      180

catgggggaa cgccaattga ggaatatact tggaatttag gtactcgttc ccgcccaaat      240

atggtctata tttattattc tcgtttagat gttggggcaa accgagtgaa cttagctatc      300

gtgtcacgcc gtcaagccga tgaagctttt atcgtacatt ctgattcttc tgtgcttcaa      360

tctcgccctg cagtaggtat ccgcattggt actgatgtat tttttacagt gcatgctttg      420

gccacaggcg gttctgatgc ggtaagtctg attcgtaata tcttcactac ttttaactca      480

tcatcatccc caccggaaag acgagtatat agctggatgg ttgttggtga tttcaatcgt      540

gcgccggcta atctggaagt tgcattaaga caggagcccg cagtgagtga aaatacaatt      600

attattgcgc caacagaacc gactcatcga tctggtaata ttttagatta tgcaatttta      660

catgatgcac atttaccacg tagagaacag gcccgtgaac gtatcggtgc aagtttaatg      720

ttaaatcagt tacgctcaca aattacatcc gatcattttc ctgttagttt tgttcgtgat      780

cgc                                                                    783


<210>  9
<211>  33
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic

<400>  9
acgcgttccg gagagaatct ttattttcaa tca                                    33


<210>  10
<211>  776
<212>  PRT
<213>  Bacillus anthracis

<400>  10

Ala Gly Gly His Gly Asp Val Gly Met His Val Lys Glu Lys Glu Lys 
1               5                   10                  15      


Asn Lys Asp Glu Asn Lys Arg Lys Asp Glu Glu Arg Asn Lys Thr Gln 
            20                  25                  30          


Glu Glu His Leu Lys Glu Ile Met Lys His Ile Val Lys Ile Glu Val 
        35                  40                  45              


Lys Gly Glu Glu Ala Val Lys Lys Glu Ala Ala Glu Lys Leu Leu Glu 
    50                  55                  60                  


Lys Val Pro Ser Asp Val Leu Glu Met Tyr Lys Ala Ile Gly Gly Lys 
65                  70                  75                  80  


Ile Tyr Ile Val Asp Gly Asp Ile Thr Lys His Ile Ser Leu Glu Ala 
                85                  90                  95      


Leu Ser Glu Asp Lys Lys Lys Ile Lys Asp Ile Tyr Gly Lys Asp Ala 
            100                 105                 110         


Leu Leu His Glu His Tyr Val Tyr Ala Lys Glu Gly Tyr Glu Pro Val 
        115                 120                 125             


Leu Val Ile Gln Ser Ser Glu Asp Tyr Val Glu Asn Thr Glu Lys Ala 
    130                 135                 140                 


Leu Asn Val Tyr Tyr Glu Ile Gly Lys Ile Leu Ser Arg Asp Ile Leu 
145                 150                 155                 160 


Ser Lys Ile Asn Gln Pro Tyr Gln Lys Phe Leu Asp Val Leu Asn Thr 
                165                 170                 175     


Ile Lys Asn Ala Ser Asp Ser Asp Gly Gln Asp Leu Leu Phe Thr Asn 
            180                 185                 190         


Gln Leu Lys Glu His Pro Thr Asp Phe Ser Val Glu Phe Leu Glu Gln 
        195                 200                 205             


Asn Ser Asn Glu Val Gln Glu Val Phe Ala Lys Ala Phe Ala Tyr Tyr 
    210                 215                 220                 


Ile Glu Pro Gln His Arg Asp Val Leu Gln Leu Tyr Ala Pro Glu Ala 
225                 230                 235                 240 


Phe Asn Tyr Met Asp Lys Phe Asn Glu Gln Glu Ile Asn Leu Ser Leu 
                245                 250                 255     


Glu Glu Leu Lys Asp Gln Arg Met Leu Ser Arg Tyr Glu Lys Trp Glu 
            260                 265                 270         


Lys Ile Lys Gln His Tyr Gln His Trp Ser Asp Ser Leu Ser Glu Glu 
        275                 280                 285             


Gly Arg Gly Leu Leu Lys Lys Leu Gln Ile Pro Ile Glu Pro Lys Lys 
    290                 295                 300                 


Asp Asp Ile Ile His Ser Leu Ser Gln Glu Glu Lys Glu Leu Leu Lys 
305                 310                 315                 320 


Arg Ile Gln Ile Asp Ser Ser Asp Phe Leu Ser Thr Glu Glu Lys Glu 
                325                 330                 335     


Phe Leu Lys Lys Leu Gln Ile Asp Ile Arg Asp Ser Leu Ser Glu Glu 
            340                 345                 350         


Glu Lys Glu Leu Leu Asn Arg Ile Gln Val Asp Ser Ser Asn Pro Leu 
        355                 360                 365             


Ser Glu Lys Glu Lys Glu Phe Leu Lys Lys Leu Lys Leu Asp Ile Gln 
    370                 375                 380                 


Pro Tyr Asp Ile Asn Gln Arg Leu Gln Asp Thr Gly Gly Leu Ile Asp 
385                 390                 395                 400 


Ser Pro Ser Ile Asn Leu Asp Val Arg Lys Gln Tyr Lys Arg Asp Ile 
                405                 410                 415     


Gln Asn Ile Asp Ala Leu Leu His Gln Ser Ile Gly Ser Thr Leu Tyr 
            420                 425                 430         


Asn Lys Ile Tyr Leu Tyr Glu Asn Met Asn Ile Asn Asn Leu Thr Ala 
        435                 440                 445             


Thr Leu Gly Ala Asp Leu Val Asp Ser Thr Asp Asn Thr Lys Ile Asn 
    450                 455                 460                 


Arg Gly Ile Phe Asn Glu Phe Lys Lys Asn Phe Lys Tyr Ser Ile Ser 
465                 470                 475                 480 


Ser Asn Tyr Met Ile Val Asp Ile Asn Glu Arg Pro Ala Leu Asp Asn 
                485                 490                 495     


Glu Arg Leu Lys Trp Arg Ile Gln Leu Ser Pro Asp Thr Arg Ala Gly 
            500                 505                 510         


Tyr Leu Glu Asn Gly Lys Leu Ile Leu Gln Arg Asn Ile Gly Leu Glu 
        515                 520                 525             


Ile Lys Asp Val Gln Ile Ile Lys Gln Ser Glu Lys Glu Tyr Ile Arg 
    530                 535                 540                 


Ile Asp Ala Lys Val Val Pro Lys Ser Lys Ile Asp Thr Lys Ile Gln 
545                 550                 555                 560 


Glu Ala Gln Leu Asn Ile Asn Gln Glu Trp Asn Lys Ala Leu Gly Leu 
                565                 570                 575     


Pro Lys Tyr Thr Lys Leu Ile Thr Phe Asn Val His Asn Arg Tyr Ala 
            580                 585                 590         


Ser Asn Ile Val Glu Ser Ala Tyr Leu Ile Leu Asn Glu Trp Lys Asn 
        595                 600                 605             


Asn Ile Gln Ser Asp Leu Ile Lys Lys Val Thr Asn Tyr Leu Val Asp 
    610                 615                 620                 


Gly Asn Gly Arg Phe Val Phe Thr Asp Ile Thr Leu Pro Asn Ile Ala 
625                 630                 635                 640 


Glu Gln Tyr Thr His Gln Asp Glu Ile Tyr Glu Gln Val His Ser Lys 
                645                 650                 655     


Gly Leu Tyr Val Pro Glu Ser Arg Ser Ile Leu Leu His Gly Pro Ser 
            660                 665                 670         


Lys Gly Val Glu Leu Arg Asn Asp Ser Glu Gly Phe Ile His Glu Phe 
        675                 680                 685             


Gly His Ala Val Asp Asp Tyr Ala Gly Tyr Leu Leu Asp Lys Asn Gln 
    690                 695                 700                 


Ser Asp Leu Val Thr Asn Ser Lys Lys Phe Ile Asp Ile Phe Lys Glu 
705                 710                 715                 720 


Glu Gly Ser Asn Leu Thr Ser Tyr Gly Arg Thr Asn Glu Ala Glu Phe 
                725                 730                 735     


Phe Ala Glu Ala Phe Arg Leu Met His Ser Thr Asp His Ala Glu Arg 
            740                 745                 750         


Leu Lys Val Gln Lys Asn Ala Pro Lys Thr Phe Gln Phe Ile Asn Asp 
        755                 760                 765             


Gln Ile Lys Phe Ile Ile Asn Ser 
    770                 775     


<210>  11
<211>  269
<212>  PRT
<213>  Escherichia coli

<400>  11

Met Lys Lys Tyr Ile Ile Ser Leu Ile Val Phe Leu Ser Phe Tyr Ala 
1               5                   10                  15      


Gln Ala Asp Leu Thr Asp Phe Arg Val Ala Thr Trp Asn Leu Gln Gly 
            20                  25                  30          


Ala Ser Ala Thr Thr Glu Ser Lys Trp Asn Ile Asn Val Arg Gln Leu 
        35                  40                  45              


Ile Ser Gly Glu Asn Ala Val Asp Ile Leu Ala Val Gln Glu Ala Gly 
    50                  55                  60                  


Ser Pro Pro Ser Thr Ala Val Asp Thr Gly Arg Val Ile Pro Ser Pro 
65                  70                  75                  80  


Gly Ile Pro Val Arg Glu Leu Ile Trp Asn Leu Ser Thr Asn Ser Arg 
                85                  90                  95      


Pro Gln Gln Val Tyr Ile Tyr Phe Ser Ala Val Asp Ala Phe Gly Gly 
            100                 105                 110         


Arg Val Asn Leu Ala Leu Val Ser Asn Arg Gln Ala Asp Glu Val Phe 
        115                 120                 125             


Val Leu Arg Pro Val Arg Gln Gly Gly Arg Pro Leu Leu Gly Ile Arg 
    130                 135                 140                 


Ile Gly Asn Asp Ala Phe Phe Thr Ala His Ala Ile Ala Thr Arg Asn 
145                 150                 155                 160 


Asn Asp Ala Pro Ala Leu Val Glu Glu Val Tyr Ser Phe Phe Arg Asp 
                165                 170                 175     


Ser Arg Asp Pro Val His Gln Ala Ile Asn Trp Met Ile Leu Gly Asp 
            180                 185                 190         


Phe Asn Arg Glu Pro Asp Asp Leu Glu Val Asn Leu Thr Val Pro Val 
        195                 200                 205             


Arg Asn Ala Ser Glu Ile Ile Phe Pro Ala Ala Pro Thr Gln Thr Ser 
    210                 215                 220                 


Gln Arg Thr Leu Asp Tyr Ala Val Ala Gly Asn Ala Val Ala Phe Arg 
225                 230                 235                 240 


Pro Phe Pro Leu Gln Ala Gly Ile Val Tyr Gly Ala Arg Arg Thr Gln 
                245                 250                 255     


Met Ser Ser Asp His Tyr Pro Val Gly Val Ser Arg Arg 
            260                 265                 


<210>  12
<211>  283
<212>  PRT
<213>  Actinobacillus sp.

<400>  12

Met Gln Trp Val Lys Gln Leu Asn Val Val Phe Cys Thr Met Leu Phe 
1               5                   10                  15      


Ser Phe Ser Ser Tyr Ala Asn Leu Ser Asp Phe Lys Val Ala Thr Trp 
            20                  25                  30          


Asn Leu Gln Gly Ser Ser Ala Val Asn Glu Ser Lys Trp Asn Ile Asn 
        35                  40                  45              


Val Arg Gln Leu Leu Ser Gly Glu Gln Gly Ala Asp Ile Leu Met Val 
    50                  55                  60                  


Gln Glu Ala Gly Ser Leu Pro Ser Ser Ala Val Arg Thr Ser Arg Val 
65                  70                  75                  80  


Ile Gln His Gly Gly Thr Pro Ile Glu Glu Tyr Thr Trp Asn Leu Gly 
                85                  90                  95      


Thr Arg Ser Arg Pro Asn Met Val Tyr Ile Tyr Tyr Ser Arg Leu Asp 
            100                 105                 110         


Val Gly Ala Asn Arg Val Asn Leu Ala Ile Val Ser Arg Arg Gln Ala 
        115                 120                 125             


Asp Glu Ala Phe Ile Val His Ser Asp Ser Ser Val Leu Gln Ser Arg 
    130                 135                 140                 


Pro Ala Val Gly Ile Arg Ile Gly Thr Asp Val Phe Phe Thr Val His 
145                 150                 155                 160 


Ala Leu Ala Thr Gly Gly Ser Asp Ala Val Ser Leu Ile Arg Asn Ile 
                165                 170                 175     


Phe Thr Thr Phe Thr Ser Ser Pro Ser Ser Pro Glu Arg Arg Gly Tyr 
            180                 185                 190         


Ser Trp Met Val Val Gly Asp Phe Asn Arg Ala Pro Val Asn Leu Glu 
        195                 200                 205             


Ala Ala Leu Arg Gln Glu Pro Ala Val Ser Glu Asn Thr Ile Ile Ile 
    210                 215                 220                 


Ala Pro Thr Glu Pro Thr His Arg Ser Gly Asn Ile Leu Asp Tyr Ala 
225                 230                 235                 240 


Ile Leu His Asp Ala His Leu Pro Arg Arg Glu Gln Ala Arg Glu Arg 
                245                 250                 255     


Ile Gly Ala Ser Leu Met Leu Asn Gln Leu Arg Ser Gln Ile Thr Ser 
            260                 265                 270         


Asp His Phe Pro Val Ser Phe Val His Asp Arg 
        275                 280             


<210>  13
<211>  265
<212>  PRT
<213>  Campylobacter jejuni

<400>  13

Met Lys Lys Ile Ile Cys Leu Phe Leu Ser Phe Asn Leu Ala Phe Ala 
1               5                   10                  15      


Asn Leu Glu Asn Phe Asn Val Gly Thr Trp Asn Leu Gln Gly Ser Ser 
            20                  25                  30          


Ala Ala Thr Glu Ser Lys Trp Ser Val Ser Val Arg Gln Leu Val Ser 
        35                  40                  45              


Gly Ala Asn Pro Leu Asp Ile Leu Met Ile Gln Glu Ala Gly Thr Leu 
    50                  55                  60                  


Pro Arg Thr Ala Thr Pro Thr Gly Arg His Val Gln Gln Gly Gly Thr 
65                  70                  75                  80  


Pro Ile Asp Glu Tyr Glu Trp Asn Leu Gly Thr Leu Ser Arg Pro Asp 
                85                  90                  95      


Arg Val Phe Ile Tyr Tyr Ser Arg Val Asp Val Gly Ala Asn Arg Val 
            100                 105                 110         


Asn Leu Ala Ile Val Ser Arg Met Gln Ala Glu Glu Val Ile Val Leu 
        115                 120                 125             


Pro Pro Pro Thr Thr Val Ser Arg Pro Ile Ile Gly Ile Arg Asn Gly 
    130                 135                 140                 


Asn Asp Ala Phe Phe Asn Ile His Ala Leu Ala Asn Gly Gly Thr Asp 
145                 150                 155                 160 


Val Gly Ala Ile Ile Thr Ala Val Asp Ala His Phe Ala Asn Met Pro 
                165                 170                 175     


Gln Val Asn Trp Met Ile Ala Gly Asp Phe Asn Arg Asp Pro Ser Thr 
            180                 185                 190         


Ile Thr Ser Thr Val Asp Arg Glu Leu Ala Asn Arg Ile Arg Val Val 
        195                 200                 205             


Phe Pro Thr Ser Ala Thr Gln Ala Ser Gly Gly Thr Leu Asp Tyr Ala 
    210                 215                 220                 


Ile Thr Gly Asn Ser Asn Arg Gln Gln Thr Tyr Thr Pro Pro Leu Leu 
225                 230                 235                 240 


Ala Ala Ile Leu Met Leu Ala Ser Leu Arg Ser His Ile Val Ser Asp 
                245                 250                 255     


His Phe Pro Val Asn Phe Arg Lys Phe 
            260                 265 


<210>  14
<211>  283
<212>  PRT
<213>  Aggregatibacter actinomycetemcomitans

<400>  14

Met Gln Trp Val Lys Gln Leu Asn Val Val Phe Cys Thr Met Leu Phe 
1               5                   10                  15      


Ser Phe Ser Ser Tyr Ala Asn Leu Ser Asp Phe Lys Val Ala Thr Trp 
            20                  25                  30          


Asn Leu Gln Gly Ser Ser Ala Val Asn Glu Ser Lys Trp Asn Ile Asn 
        35                  40                  45              


Val Arg Gln Leu Leu Ser Gly Glu Gln Gly Ala Asp Ile Leu Met Val 
    50                  55                  60                  


Gln Glu Ala Gly Ser Leu Pro Ser Ser Ala Val Arg Thr Ser Arg Val 
65                  70                  75                  80  


Ile Gln His Gly Gly Thr Pro Ile Glu Glu Tyr Thr Trp Asn Leu Gly 
                85                  90                  95      


Thr Arg Ser Arg Pro Asn Met Val Tyr Ile Tyr Tyr Ser Arg Leu Asp 
            100                 105                 110         


Val Gly Ala Asn Arg Val Asn Leu Ala Ile Val Ser Arg Arg Gln Ala 
        115                 120                 125             


Asp Glu Ala Phe Ile Val His Ser Asp Ser Ser Val Leu Gln Ser Arg 
    130                 135                 140                 


Pro Ala Val Gly Ile Arg Ile Gly Thr Asp Val Phe Phe Thr Val His 
145                 150                 155                 160 


Ala Leu Ala Thr Gly Gly Ser Asp Ala Val Ser Leu Ile Arg Asn Ile 
                165                 170                 175     


Phe Thr Thr Phe Thr Ser Ser Pro Ser Ser Pro Glu Arg Arg Gly Tyr 
            180                 185                 190         


Ser Trp Met Val Val Gly Asp Phe Asn Arg Ala Pro Val Asn Leu Glu 
        195                 200                 205             


Ala Ala Leu Arg Gln Glu Pro Ala Val Ser Glu Asn Thr Ile Ile Ile 
    210                 215                 220                 


Ala Pro Thr Glu Pro Thr His Arg Ser Gly Asn Ile Leu Asp Tyr Ala 
225                 230                 235                 240 


Ile Leu His Asp Ala His Leu Pro Arg Arg Glu Gln Ala Arg Glu Arg 
                245                 250                 255     


Ile Gly Ala Ser Leu Met Leu Asn Gln Leu Arg Ser Gln Ile Thr Ser 
            260                 265                 270         


Asp His Phe Pro Val Ser Phe Val Arg Asp Arg 
        275                 280             


<210>  15
<211>  269
<212>  PRT
<213>  Salmonella enterica subsp. enterica serovar Typhi

<400>  15

Met Lys Lys Pro Val Phe Phe Leu Leu Thr Met Ile Ile Cys Ser Tyr 
1               5                   10                  15      


Ile Ser Phe Ala Cys Ala Asn Ile Ser Asp Tyr Lys Val Met Thr Trp 
            20                  25                  30          


Asn Leu Gln Gly Ser Ser Ala Ser Thr Glu Ser Lys Trp Asn Val Asn 
        35                  40                  45              


Val Arg Gln Leu Leu Ser Gly Thr Ala Gly Val Asp Ile Leu Met Val 
    50                  55                  60                  


Gln Glu Ala Gly Ala Val Pro Thr Ser Ala Val Pro Thr Gly Arg His 
65                  70                  75                  80  


Ile Gln Pro Phe Gly Val Gly Ile Pro Ile Asp Glu Tyr Thr Trp Asn 
                85                  90                  95      


Leu Gly Thr Thr Ser Arg Gln Asp Ile Arg Tyr Ile Tyr His Ser Ala 
            100                 105                 110         


Ile Asp Val Gly Ala Arg Arg Val Asn Leu Ala Ile Val Ser Arg Gln 
        115                 120                 125             


Arg Ala Asp Asn Val Tyr Val Leu Arg Pro Thr Thr Val Ala Ser Arg 
    130                 135                 140                 


Pro Val Ile Gly Ile Gly Leu Gly Asn Asp Val Phe Leu Thr Ala His 
145                 150                 155                 160 


Ala Leu Ala Ser Gly Gly Pro Asp Ala Ala Ala Ile Val Arg Val Thr 
                165                 170                 175     


Ile Asn Phe Phe Arg Gln Pro Gln Met Arg His Leu Ser Trp Phe Leu 
            180                 185                 190         


Ala Gly Asp Phe Asn Arg Ser Pro Asp Arg Leu Glu Asn Asp Leu Met 
        195                 200                 205             


Thr Glu His Leu Glu Arg Val Val Ala Val Leu Ala Pro Thr Glu Pro 
    210                 215                 220                 


Thr Gln Ile Gly Gly Gly Ile Leu Asp Tyr Gly Val Ile Val Asp Arg 
225                 230                 235                 240 


Ala Pro Tyr Ser Gln Arg Val Glu Ala Leu Arg Asn Pro Gln Leu Ala 
                245                 250                 255     


Ser Asp His Tyr Pro Val Ala Phe Leu Ala Arg Ser Cys 
            260                 265                 


<210>  16
<211>  233
<212>  PRT
<213>  Helicobacter bilis

<400>  16

Ser Ser Ala Ser Thr Glu Asn Lys Trp Asn Val Ser Val Arg Gln Leu 
1               5                   10                  15      


Ile Thr Gly Asp Asn Pro Val Asp Ile Leu Met Val Gln Glu Ala Gly 
            20                  25                  30          


Ser Val Pro Thr Ser Ala Arg Pro Thr Gly Arg Met Ile Gln Pro Gly 
        35                  40                  45              


Gly Thr Pro Ile Gln Glu Tyr Val Trp Asp Leu Gly Thr Arg Ser Arg 
    50                  55                  60                  


Pro Arg Ser Val Phe Ile Tyr Tyr Ala Asn Ile Asp Ala Gly Ala Arg 
65                  70                  75                  80  


Arg Val Asn Leu Ala Ile Val Ser Gly Arg Gln Ala Asp Glu Val Phe 
                85                  90                  95      


Val Ile Ser Gln Ser Thr Ile Ala Pro Glu Val Ser Arg Pro Val Ile 
            100                 105                 110         


Gly Ile Arg Leu Gly Asn Asp Val Phe Phe Asn Ile His Ala Leu Ala 
        115                 120                 125             


Arg Gly Gly Gly Asp Ala Ala Ala Leu Val Thr Ala Val His Asp His 
    130                 135                 140                 


Phe Val Gly Gln Pro Ser Ile Asn Trp Leu Ile Ala Gly Asp Phe Asn 
145                 150                 155                 160 


Arg Asp Pro Ala Asn Leu Leu Ser Gly Leu Asp Thr Arg Ile Thr Asn 
                165                 170                 175     


His Thr Arg Ile Val Thr Gln Asn Ser Ala Thr His Phe Ser Met Gly 
            180                 185                 190         


Ala Ala Asn Arg Ile Leu Asp Tyr Ala Ile Val Gly Arg Ser Ser Asn 
        195                 200                 205             


Asp Arg Ser Arg Leu Ala Leu Pro Thr Ile Thr Ala Leu Leu Met Ala 
    210                 215                 220                 


Ala Ser Val Arg Ser His Leu Ser Ser 
225                 230             


<210>  17
<211>  269
<212>  PRT
<213>  Providencia alcalifaciens

<400>  17

Met Ile Lys Tyr Ile Ile Ser Leu Ile Val Phe Leu Ser Phe Tyr Ala 
1               5                   10                  15      


Gln Ala Asp Leu Thr Asp Phe Arg Val Ala Thr Trp Asn Leu Gln Gly 
            20                  25                  30          


Ala Ser Ala Thr Thr Glu Ser Lys Trp Asn Ile Asn Val Arg Gln Leu 
        35                  40                  45              


Ile Ser Gly Glu Asn Ala Val Asp Ile Leu Ala Ile Gln Glu Ala Gly 
    50                  55                  60                  


Ser Pro Pro Ser Thr Ala Val Asp Thr Gly Arg Val Ile His Ser Pro 
65                  70                  75                  80  


Gly Ile Pro Ile Arg Glu Leu Ile Trp Asn Leu Ser Thr Asn Ser Arg 
                85                  90                  95      


Pro Glu Gln Val Tyr Ile Tyr Phe Ser Ala Val Asp Ala Leu Gly Gly 
            100                 105                 110         


Arg Val Asn Leu Ala Leu Ile Ser Asn Arg Arg Ala Asp Glu Val Phe 
        115                 120                 125             


Val Leu Ser Pro Val Arg Gln Gly Gly Arg Pro Leu Leu Gly Ile Arg 
    130                 135                 140                 


Ile Gly Asn Asp Ala Phe Phe Thr Ala His Ala Ile Ala Thr Arg Asn 
145                 150                 155                 160 


Asn Asp Ala Pro Ala Leu Val Glu Glu Val Tyr Asn Phe Phe Arg Asp 
                165                 170                 175     


Ser Arg Asp Pro Leu His Gln Ala Leu Asn Trp Met Ile Leu Gly Asp 
            180                 185                 190         


Phe Asn Arg Glu Pro Asp Asp Leu Glu Met Asn Leu Thr Val Pro Val 
        195                 200                 205             


Arg Asn Ala Ser Glu Ile Ile Phe Pro Ala Ala Ala Thr Gln Thr Ser 
    210                 215                 220                 


Gln Arg Thr Leu Asp Tyr Ala Val Ala Gly Asn Ala Val Ala Phe Arg 
225                 230                 235                 240 


Pro Leu Pro Leu Gln Ala Gly Ile Val Tyr Gly Ala Arg Arg Thr Gln 
                245                 250                 255     


Ile Ser Ser Asp His Tyr Pro Val Gly Val Phe Arg Arg 
            260                 265                 


