                         SEQUENCE LISTING

<110>  Calysta Energy, Inc.
       Silverman, Josh
       Saville, Renee M.
       Lee, Sungwon
       Regitsky, Drew D.
       Resnick, Sol M.
 
<120>  Compositions and Methods for Biological Production of Lactate

<130>  200206.414WO

<150>  US 61/836,609
<151>  2013-06-18

<150>  US 61/928,390
<151>  2014-01-16

<160>  67    

<170>  PatentIn version 3.5

<210>  1
<211>  987
<212>  DNA
<213>  Artificial

<220>
<223>  Synthetic construct (Streptococcus bovis LDH)


<220>
<221>  CDS
<222>  (1)..(987)

<400>  1
atg acc gcg acc aag cag cac aaa aaa gtt atc ctg gtt gga gat ggg         48
Met Thr Ala Thr Lys Gln His Lys Lys Val Ile Leu Val Gly Asp Gly           
1               5                   10                  15                

gcc gtg ggc tcg tcg tat gcg ttc gcc ctc gtc aac cag ggc ata gcc         96
Ala Val Gly Ser Ser Tyr Ala Phe Ala Leu Val Asn Gln Gly Ile Ala           
            20                  25                  30                    

cag gaa ctg ggc atc atc gag atc ccg cag ttg ttc gac aaa gcc gtc        144
Gln Glu Leu Gly Ile Ile Glu Ile Pro Gln Leu Phe Asp Lys Ala Val           
        35                  40                  45                        

ggt gac gcc gag gac ctc agc cac gct ctt gcc ttc acc agc cct aaa        192
Gly Asp Ala Glu Asp Leu Ser His Ala Leu Ala Phe Thr Ser Pro Lys           
    50                  55                  60                            

aag atc tac gcg gca aag tac gag gat tgc gcc gac gcg gac ctg gta        240
Lys Ile Tyr Ala Ala Lys Tyr Glu Asp Cys Ala Asp Ala Asp Leu Val           
65                  70                  75                  80            

gtg atc acc gcc gga gcg ccc cag aag ccc ggt gaa acg cgc ctg gac        288
Val Ile Thr Ala Gly Ala Pro Gln Lys Pro Gly Glu Thr Arg Leu Asp           
                85                  90                  95                

ctg gtc ggg aag aac ttg gct atc aat aag tca att gtc acc gaa gtg        336
Leu Val Gly Lys Asn Leu Ala Ile Asn Lys Ser Ile Val Thr Glu Val           
            100                 105                 110                   

gtc aag tcg ggg ttc aac ggc att ttc ctc gtg gcc gcg aat cca gtg        384
Val Lys Ser Gly Phe Asn Gly Ile Phe Leu Val Ala Ala Asn Pro Val           
        115                 120                 125                       

gac gtg ctg aca tac agc acc tgg aag ttc tcc ggc ttc ccg aag gaa        432
Asp Val Leu Thr Tyr Ser Thr Trp Lys Phe Ser Gly Phe Pro Lys Glu           
    130                 135                 140                           

cgg gtc atc ggt agc ggc acg agc ctg gac tcg gcc agg ttt cgg caa        480
Arg Val Ile Gly Ser Gly Thr Ser Leu Asp Ser Ala Arg Phe Arg Gln           
145                 150                 155                 160           

gcc ctg gcg gag aag ctg gat gtc gat gcc cgc tcc gtc cac gca tac        528
Ala Leu Ala Glu Lys Leu Asp Val Asp Ala Arg Ser Val His Ala Tyr           
                165                 170                 175               

atc atg ggc gag cat ggc gac tcg gag ttc gcc gtg tgg agc cat gcg        576
Ile Met Gly Glu His Gly Asp Ser Glu Phe Ala Val Trp Ser His Ala           
            180                 185                 190                   

aat gtc gct ggg gtg aat ctg gag aac tat ctg aaa gac gtc cag aac        624
Asn Val Ala Gly Val Asn Leu Glu Asn Tyr Leu Lys Asp Val Gln Asn           
        195                 200                 205                       

gtg aac gaa gcg gaa ctc gtg gag ctg ttc gag ggc gtc cgt gat gcg        672
Val Asn Glu Ala Glu Leu Val Glu Leu Phe Glu Gly Val Arg Asp Ala           
    210                 215                 220                           

gcg tat tcc atc atc aac aaa aag ggc gcc act ttc tac ggc atc gcc        720
Ala Tyr Ser Ile Ile Asn Lys Lys Gly Ala Thr Phe Tyr Gly Ile Ala           
225                 230                 235                 240           

gtg gcg ctc gcc cgg atc acg aag gcc att ttg aac gat gaa aac gcc        768
Val Ala Leu Ala Arg Ile Thr Lys Ala Ile Leu Asn Asp Glu Asn Ala           
                245                 250                 255               

gtc ctg ccg ctg tcc gtg ttc cag gaa ggg cag tat ccg ggt gtg acc        816
Val Leu Pro Leu Ser Val Phe Gln Glu Gly Gln Tyr Pro Gly Val Thr           
            260                 265                 270                   

gac tgc tac atc ggc cag ccc gcc atc gtc gga gcc cat ggc atc gta        864
Asp Cys Tyr Ile Gly Gln Pro Ala Ile Val Gly Ala His Gly Ile Val           
        275                 280                 285                       

cgc ccc gtc aac atc ccg ctc aac gac gcg gag cag caa aag atg gaa        912
Arg Pro Val Asn Ile Pro Leu Asn Asp Ala Glu Gln Gln Lys Met Glu           
    290                 295                 300                           

gca tct gca aaa gaa ctg aag gcc atc atc gac gaa gcc ttc tcc aaa        960
Ala Ser Ala Lys Glu Leu Lys Ala Ile Ile Asp Glu Ala Phe Ser Lys           
305                 310                 315                 320           

gaa gag ttt gcc agt gcg gcg aag taa                                    987
Glu Glu Phe Ala Ser Ala Ala Lys                                           
                325                                                       


<210>  2
<211>  328
<212>  PRT
<213>  Artificial

<220>
<223>  Synthetic Construct

<400>  2

Met Thr Ala Thr Lys Gln His Lys Lys Val Ile Leu Val Gly Asp Gly 
1               5                   10                  15      


Ala Val Gly Ser Ser Tyr Ala Phe Ala Leu Val Asn Gln Gly Ile Ala 
            20                  25                  30          


Gln Glu Leu Gly Ile Ile Glu Ile Pro Gln Leu Phe Asp Lys Ala Val 
        35                  40                  45              


Gly Asp Ala Glu Asp Leu Ser His Ala Leu Ala Phe Thr Ser Pro Lys 
    50                  55                  60                  


Lys Ile Tyr Ala Ala Lys Tyr Glu Asp Cys Ala Asp Ala Asp Leu Val 
65                  70                  75                  80  


Val Ile Thr Ala Gly Ala Pro Gln Lys Pro Gly Glu Thr Arg Leu Asp 
                85                  90                  95      


Leu Val Gly Lys Asn Leu Ala Ile Asn Lys Ser Ile Val Thr Glu Val 
            100                 105                 110         


Val Lys Ser Gly Phe Asn Gly Ile Phe Leu Val Ala Ala Asn Pro Val 
        115                 120                 125             


Asp Val Leu Thr Tyr Ser Thr Trp Lys Phe Ser Gly Phe Pro Lys Glu 
    130                 135                 140                 


Arg Val Ile Gly Ser Gly Thr Ser Leu Asp Ser Ala Arg Phe Arg Gln 
145                 150                 155                 160 


Ala Leu Ala Glu Lys Leu Asp Val Asp Ala Arg Ser Val His Ala Tyr 
                165                 170                 175     


Ile Met Gly Glu His Gly Asp Ser Glu Phe Ala Val Trp Ser His Ala 
            180                 185                 190         


Asn Val Ala Gly Val Asn Leu Glu Asn Tyr Leu Lys Asp Val Gln Asn 
        195                 200                 205             


Val Asn Glu Ala Glu Leu Val Glu Leu Phe Glu Gly Val Arg Asp Ala 
    210                 215                 220                 


Ala Tyr Ser Ile Ile Asn Lys Lys Gly Ala Thr Phe Tyr Gly Ile Ala 
225                 230                 235                 240 


Val Ala Leu Ala Arg Ile Thr Lys Ala Ile Leu Asn Asp Glu Asn Ala 
                245                 250                 255     


Val Leu Pro Leu Ser Val Phe Gln Glu Gly Gln Tyr Pro Gly Val Thr 
            260                 265                 270         


Asp Cys Tyr Ile Gly Gln Pro Ala Ile Val Gly Ala His Gly Ile Val 
        275                 280                 285             


Arg Pro Val Asn Ile Pro Leu Asn Asp Ala Glu Gln Gln Lys Met Glu 
    290                 295                 300                 


Ala Ser Ala Lys Glu Leu Lys Ala Ile Ile Asp Glu Ala Phe Ser Lys 
305                 310                 315                 320 


Glu Glu Phe Ala Ser Ala Ala Lys 
                325             


<210>  3
<211>  924
<212>  DNA
<213>  Artificial

<220>
<223>  Synthetic construct (Lactobacillus helveticus LDH)


<220>
<221>  CDS
<222>  (1)..(924)

<400>  3
atg tct agg aaa gtg ttt ctt gtg ggt gat ggt gcg gtg ggg tca acg         48
Met Ser Arg Lys Val Phe Leu Val Gly Asp Gly Ala Val Gly Ser Thr           
1               5                   10                  15                

ttt gcg aac gat ttg ttg cag aat gcg aaa gtg gac gag ctc gcc atc         96
Phe Ala Asn Asp Leu Leu Gln Asn Ala Lys Val Asp Glu Leu Ala Ile           
            20                  25                  30                    

ttc gag gtc gcc aag gat cgg ccg gta ggc gac gcg atg gac ctg gaa        144
Phe Glu Val Ala Lys Asp Arg Pro Val Gly Asp Ala Met Asp Leu Glu           
        35                  40                  45                        

gat atc acc ccc ttc atg ggc cag acg gat atc cac ccg gca gac tac        192
Asp Ile Thr Pro Phe Met Gly Gln Thr Asp Ile His Pro Ala Asp Tyr           
    50                  55                  60                            

tcg gac gcg aaa gac gcc gac gtg tgc gtc atc gct gcg ggt gtg ccc        240
Ser Asp Ala Lys Asp Ala Asp Val Cys Val Ile Ala Ala Gly Val Pro           
65                  70                  75                  80            

cgc aag ccc ggt gaa aca cgg ctc gac ctg gtc gcg aaa aac gtc aag        288
Arg Lys Pro Gly Glu Thr Arg Leu Asp Leu Val Ala Lys Asn Val Lys           
                85                  90                  95                

ata ctg aag tcc atc gtg cag ccg gtc gtg gaa tcc ggc ttc aaa ggc        336
Ile Leu Lys Ser Ile Val Gln Pro Val Val Glu Ser Gly Phe Lys Gly           
            100                 105                 110                   

gtg ttc gtt gtg tcg gcg aac ccg gtc gac att ctg acc acc ctc acg        384
Val Phe Val Val Ser Ala Asn Pro Val Asp Ile Leu Thr Thr Leu Thr           
        115                 120                 125                       

cag aag ttg agt ggc ttc ccg aag aac cgc gtg atc gga acc ggc acc        432
Gln Lys Leu Ser Gly Phe Pro Lys Asn Arg Val Ile Gly Thr Gly Thr           
    130                 135                 140                           

agc ctg gat tcg atg cgt ctg cgc gtg gag ctc gcc aag aaa ctg aac        480
Ser Leu Asp Ser Met Arg Leu Arg Val Glu Leu Ala Lys Lys Leu Asn           
145                 150                 155                 160           

gtt ccc gtc gct aag gtc aat agc atg gtc ctc gga gaa cac ggc gac        528
Val Pro Val Ala Lys Val Asn Ser Met Val Leu Gly Glu His Gly Asp           
                165                 170                 175               

acg tcg ttc gag aat ttc gac gag agc acc gtg gac ggc aag ccg ctg        576
Thr Ser Phe Glu Asn Phe Asp Glu Ser Thr Val Asp Gly Lys Pro Leu           
            180                 185                 190                   

cgc gac tac gcc gag atc aac gac gat gtc ctg agc gag atc gaa acc        624
Arg Asp Tyr Ala Glu Ile Asn Asp Asp Val Leu Ser Glu Ile Glu Thr           
        195                 200                 205                       

gac gtc cga aag aaa ggc gag aag atc atc gcc aaa aag ggc gcc acg        672
Asp Val Arg Lys Lys Gly Glu Lys Ile Ile Ala Lys Lys Gly Ala Thr           
    210                 215                 220                           

ttc tat ggg gtc gcc atg atg ctg acc cag atc gta tcc gcc att ctg        720
Phe Tyr Gly Val Ala Met Met Leu Thr Gln Ile Val Ser Ala Ile Leu           
225                 230                 235                 240           

gac aat cgg tcc atc tgc ctg ccg ctg agc gcc cct atc aac ggc gaa        768
Asp Asn Arg Ser Ile Cys Leu Pro Leu Ser Ala Pro Ile Asn Gly Glu           
                245                 250                 255               

tat ggc atc aag cat gac ctc tac ctg ggc acc cca gcc gtg atc aac        816
Tyr Gly Ile Lys His Asp Leu Tyr Leu Gly Thr Pro Ala Val Ile Asn           
            260                 265                 270                   

ggg gaa ggg atc gaa cag gtc atc gag act aag ctg tcg gat gcc gaa        864
Gly Glu Gly Ile Glu Gln Val Ile Glu Thr Lys Leu Ser Asp Ala Glu           
        275                 280                 285                       

aag gcc aag atg att aac tcc gca gat aag atg caa gaa gtc ctg ggc        912
Lys Ala Lys Met Ile Asn Ser Ala Asp Lys Met Gln Glu Val Leu Gly           
    290                 295                 300                           

gga atc gag taa                                                        924
Gly Ile Glu                                                               
305                                                                       


<210>  4
<211>  307
<212>  PRT
<213>  Artificial

<220>
<223>  Synthetic Construct

<400>  4

Met Ser Arg Lys Val Phe Leu Val Gly Asp Gly Ala Val Gly Ser Thr 
1               5                   10                  15      


Phe Ala Asn Asp Leu Leu Gln Asn Ala Lys Val Asp Glu Leu Ala Ile 
            20                  25                  30          


Phe Glu Val Ala Lys Asp Arg Pro Val Gly Asp Ala Met Asp Leu Glu 
        35                  40                  45              


Asp Ile Thr Pro Phe Met Gly Gln Thr Asp Ile His Pro Ala Asp Tyr 
    50                  55                  60                  


Ser Asp Ala Lys Asp Ala Asp Val Cys Val Ile Ala Ala Gly Val Pro 
65                  70                  75                  80  


Arg Lys Pro Gly Glu Thr Arg Leu Asp Leu Val Ala Lys Asn Val Lys 
                85                  90                  95      


Ile Leu Lys Ser Ile Val Gln Pro Val Val Glu Ser Gly Phe Lys Gly 
            100                 105                 110         


Val Phe Val Val Ser Ala Asn Pro Val Asp Ile Leu Thr Thr Leu Thr 
        115                 120                 125             


Gln Lys Leu Ser Gly Phe Pro Lys Asn Arg Val Ile Gly Thr Gly Thr 
    130                 135                 140                 


Ser Leu Asp Ser Met Arg Leu Arg Val Glu Leu Ala Lys Lys Leu Asn 
145                 150                 155                 160 


Val Pro Val Ala Lys Val Asn Ser Met Val Leu Gly Glu His Gly Asp 
                165                 170                 175     


Thr Ser Phe Glu Asn Phe Asp Glu Ser Thr Val Asp Gly Lys Pro Leu 
            180                 185                 190         


Arg Asp Tyr Ala Glu Ile Asn Asp Asp Val Leu Ser Glu Ile Glu Thr 
        195                 200                 205             


Asp Val Arg Lys Lys Gly Glu Lys Ile Ile Ala Lys Lys Gly Ala Thr 
    210                 215                 220                 


Phe Tyr Gly Val Ala Met Met Leu Thr Gln Ile Val Ser Ala Ile Leu 
225                 230                 235                 240 


Asp Asn Arg Ser Ile Cys Leu Pro Leu Ser Ala Pro Ile Asn Gly Glu 
                245                 250                 255     


Tyr Gly Ile Lys His Asp Leu Tyr Leu Gly Thr Pro Ala Val Ile Asn 
            260                 265                 270         


Gly Glu Gly Ile Glu Gln Val Ile Glu Thr Lys Leu Ser Asp Ala Glu 
        275                 280                 285             


Lys Ala Lys Met Ile Asn Ser Ala Asp Lys Met Gln Glu Val Leu Gly 
    290                 295                 300                 


Gly Ile Glu 
305         


<210>  5
<211>  1002
<212>  DNA
<213>  Artificial

<220>
<223>  Synthetic construct (Bos taurus LDH variant)


<220>
<221>  CDS
<222>  (1)..(1002)

<400>  5
atg gcg act ctc aaa gat cag ctc ata cag aac ttg ctt aaa gaa gaa         48
Met Ala Thr Leu Lys Asp Gln Leu Ile Gln Asn Leu Leu Lys Glu Glu           
1               5                   10                  15                

cat gtg ccc cag aac aag atc acc atc gtg ggt gtg ggc gcc gtt ggg         96
His Val Pro Gln Asn Lys Ile Thr Ile Val Gly Val Gly Ala Val Gly           
            20                  25                  30                    

atg gcc tgc gcg atc agc atc ctg atg aaa gat ctc gcc gac gaa gtc        144
Met Ala Cys Ala Ile Ser Ile Leu Met Lys Asp Leu Ala Asp Glu Val           
        35                  40                  45                        

gca ctg gtt gac gtg atg gaa gat aag ctc aag ggt aat gaa atg atg        192
Ala Leu Val Asp Val Met Glu Asp Lys Leu Lys Gly Asn Glu Met Met           
    50                  55                  60                            

gac ctc cag cat ggg tca ctg ttc ctg cga acc cca aag att gtc tcc        240
Asp Leu Gln His Gly Ser Leu Phe Leu Arg Thr Pro Lys Ile Val Ser           
65                  70                  75                  80            

gga aag gac tac aac gtc acc gcc aac agc cgg ctg gtg atc atc acg        288
Gly Lys Asp Tyr Asn Val Thr Ala Asn Ser Arg Leu Val Ile Ile Thr           
                85                  90                  95                

gct ggg gca cgc caa cag gaa ggc gag tcg agg ctg aac ctc gtc cag        336
Ala Gly Ala Arg Gln Gln Glu Gly Glu Ser Arg Leu Asn Leu Val Gln           
            100                 105                 110                   

cgc aat gtc aac atc ttt aag ttc atc atc ccg aac atc gtg aag tac        384
Arg Asn Val Asn Ile Phe Lys Phe Ile Ile Pro Asn Ile Val Lys Tyr           
        115                 120                 125                       

tcc ccg aac tgc aag ctg ttg gtt gtg tcg aat ccc gtg gat atc ctg        432
Ser Pro Asn Cys Lys Leu Leu Val Val Ser Asn Pro Val Asp Ile Leu           
    130                 135                 140                           

acg tac gtc gcc tgg aag att tcg ggc ttc ccc aag aac cgg gta atc        480
Thr Tyr Val Ala Trp Lys Ile Ser Gly Phe Pro Lys Asn Arg Val Ile           
145                 150                 155                 160           

ggc agc ggc tgt aac ctg gat agc gcg cgt ttc cgc tac ctg atg ggc        528
Gly Ser Gly Cys Asn Leu Asp Ser Ala Arg Phe Arg Tyr Leu Met Gly           
                165                 170                 175               

gag cgc ttg gga gtc cac ccg ctg agc tgc cac ggg tgg atc ctc ggt        576
Glu Arg Leu Gly Val His Pro Leu Ser Cys His Gly Trp Ile Leu Gly           
            180                 185                 190                   

gag cat ggc gac tcc tcg gtg cct gtc tgg tct ggc gtc aat gta gcc        624
Glu His Gly Asp Ser Ser Val Pro Val Trp Ser Gly Val Asn Val Ala           
        195                 200                 205                       

ggc gtc agt ctg aag aat ctg cac ccc gag ctg ggc acc gac gcc gac        672
Gly Val Ser Leu Lys Asn Leu His Pro Glu Leu Gly Thr Asp Ala Asp           
    210                 215                 220                           

aaa gag cag tgg aaa gcc gtc cac aag caa gtg gtg gac tcg gcg tat        720
Lys Glu Gln Trp Lys Ala Val His Lys Gln Val Val Asp Ser Ala Tyr           
225                 230                 235                 240           

gaa gtc atc aag ctg aag ggc tat acc agt tgg gcg atc ggc ctg agc        768
Glu Val Ile Lys Leu Lys Gly Tyr Thr Ser Trp Ala Ile Gly Leu Ser           
                245                 250                 255               

gtg gcc gac ctg gcg gag tcc att atg aag aac ctt cgg cgc gtc cac        816
Val Ala Asp Leu Ala Glu Ser Ile Met Lys Asn Leu Arg Arg Val His           
            260                 265                 270                   

ccg atc tcg acc atg atc aaa ggc ctc tac ggg atc aaa gaa gat gtg        864
Pro Ile Ser Thr Met Ile Lys Gly Leu Tyr Gly Ile Lys Glu Asp Val           
        275                 280                 285                       

ttc ctc tcc gtc ccg tgc atc ttg ggc cag aac gga atc tcc gac gtc        912
Phe Leu Ser Val Pro Cys Ile Leu Gly Gln Asn Gly Ile Ser Asp Val           
    290                 295                 300                           

gtg aag gtc aca ctg acg cat gaa gaa gaa gcg tgc ctg aag aag tcg        960
Val Lys Val Thr Leu Thr His Glu Glu Glu Ala Cys Leu Lys Lys Ser           
305                 310                 315                 320           

gcc gac acc ctg tgg ggc atc cag aaa gaa cta cag ttc taa               1002
Ala Asp Thr Leu Trp Gly Ile Gln Lys Glu Leu Gln Phe                       
                325                 330                                   


<210>  6
<211>  333
<212>  PRT
<213>  Artificial

<220>
<223>  Synthetic Construct

<400>  6

Met Ala Thr Leu Lys Asp Gln Leu Ile Gln Asn Leu Leu Lys Glu Glu 
1               5                   10                  15      


His Val Pro Gln Asn Lys Ile Thr Ile Val Gly Val Gly Ala Val Gly 
            20                  25                  30          


Met Ala Cys Ala Ile Ser Ile Leu Met Lys Asp Leu Ala Asp Glu Val 
        35                  40                  45              


Ala Leu Val Asp Val Met Glu Asp Lys Leu Lys Gly Asn Glu Met Met 
    50                  55                  60                  


Asp Leu Gln His Gly Ser Leu Phe Leu Arg Thr Pro Lys Ile Val Ser 
65                  70                  75                  80  


Gly Lys Asp Tyr Asn Val Thr Ala Asn Ser Arg Leu Val Ile Ile Thr 
                85                  90                  95      


Ala Gly Ala Arg Gln Gln Glu Gly Glu Ser Arg Leu Asn Leu Val Gln 
            100                 105                 110         


Arg Asn Val Asn Ile Phe Lys Phe Ile Ile Pro Asn Ile Val Lys Tyr 
        115                 120                 125             


Ser Pro Asn Cys Lys Leu Leu Val Val Ser Asn Pro Val Asp Ile Leu 
    130                 135                 140                 


Thr Tyr Val Ala Trp Lys Ile Ser Gly Phe Pro Lys Asn Arg Val Ile 
145                 150                 155                 160 


Gly Ser Gly Cys Asn Leu Asp Ser Ala Arg Phe Arg Tyr Leu Met Gly 
                165                 170                 175     


Glu Arg Leu Gly Val His Pro Leu Ser Cys His Gly Trp Ile Leu Gly 
            180                 185                 190         


Glu His Gly Asp Ser Ser Val Pro Val Trp Ser Gly Val Asn Val Ala 
        195                 200                 205             


Gly Val Ser Leu Lys Asn Leu His Pro Glu Leu Gly Thr Asp Ala Asp 
    210                 215                 220                 


Lys Glu Gln Trp Lys Ala Val His Lys Gln Val Val Asp Ser Ala Tyr 
225                 230                 235                 240 


Glu Val Ile Lys Leu Lys Gly Tyr Thr Ser Trp Ala Ile Gly Leu Ser 
                245                 250                 255     


Val Ala Asp Leu Ala Glu Ser Ile Met Lys Asn Leu Arg Arg Val His 
            260                 265                 270         


Pro Ile Ser Thr Met Ile Lys Gly Leu Tyr Gly Ile Lys Glu Asp Val 
        275                 280                 285             


Phe Leu Ser Val Pro Cys Ile Leu Gly Gln Asn Gly Ile Ser Asp Val 
    290                 295                 300                 


Val Lys Val Thr Leu Thr His Glu Glu Glu Ala Cys Leu Lys Lys Ser 
305                 310                 315                 320 


Ala Asp Thr Leu Trp Gly Ile Gln Lys Glu Leu Gln Phe 
                325                 330             


<210>  7
<211>  260
<212>  DNA
<213>  Artificial

<220>
<223>  Synthetic construct (Pediococcus acidilactici LDH)


<220>
<221>  CDS
<222>  (1)..(258)

<400>  7
atg tct aat att caa aat cat caa aaa gtt gtc ctc gtc ggt gac ggt         48
Met Ser Asn Ile Gln Asn His Gln Lys Val Val Leu Val Gly Asp Gly           
1               5                   10                  15                

gcc gta ggt tct agt tac gca ttc gcg atg gca caa caa gga atc gct         96
Ala Val Gly Ser Ser Tyr Ala Phe Ala Met Ala Gln Gln Gly Ile Ala           
            20                  25                  30                    

gaa gaa ttc gtc att gtc gac gtt gtt aag gat cgt aca gtt ggg gac        144
Glu Glu Phe Val Ile Val Asp Val Val Lys Asp Arg Thr Val Gly Asp           
        35                  40                  45                        

gca ttg gac ctt gaa gat gct act cca ttc aca gct cca aag aac atc        192
Ala Leu Asp Leu Glu Asp Ala Thr Pro Phe Thr Ala Pro Lys Asn Ile           
    50                  55                  60                            

tac tct ggt gaa tac tca gac tgc aag gat gct gac tta gtt gtt atc        240
Tyr Ser Gly Glu Tyr Ser Asp Cys Lys Asp Ala Asp Leu Val Val Ile           
65                  70                  75                  80            

aca gct ggc gca cca caa aa                                             260
Thr Ala Gly Ala Pro Gln                                                   
                85                                                        


<210>  8
<211>  86
<212>  PRT
<213>  Artificial

<220>
<223>  Synthetic Construct

<400>  8

Met Ser Asn Ile Gln Asn His Gln Lys Val Val Leu Val Gly Asp Gly 
1               5                   10                  15      


Ala Val Gly Ser Ser Tyr Ala Phe Ala Met Ala Gln Gln Gly Ile Ala 
            20                  25                  30          


Glu Glu Phe Val Ile Val Asp Val Val Lys Asp Arg Thr Val Gly Asp 
        35                  40                  45              


Ala Leu Asp Leu Glu Asp Ala Thr Pro Phe Thr Ala Pro Lys Asn Ile 
    50                  55                  60                  


Tyr Ser Gly Glu Tyr Ser Asp Cys Lys Asp Ala Asp Leu Val Val Ile 
65                  70                  75                  80  


Thr Ala Gly Ala Pro Gln 
                85      


<210>  9
<211>  963
<212>  DNA
<213>  Artificial

<220>
<223>  Synthetic construct (Rhizopus oryzae LDH)


<220>
<221>  CDS
<222>  (1)..(963)

<400>  9
atg gta tta cac agc aaa gtc gca ata gtc gga gcg gga gca gtt ggc         48
Met Val Leu His Ser Lys Val Ala Ile Val Gly Ala Gly Ala Val Gly           
1               5                   10                  15                

gca tct aca gca tac gcg ttg atg ttc aag aac atc tgc acg gaa att         96
Ala Ser Thr Ala Tyr Ala Leu Met Phe Lys Asn Ile Cys Thr Glu Ile           
            20                  25                  30                    

atc gtg gtc gac gtg aac ccc gat atc gtg cag gcc cag gtg ctg gac        144
Ile Val Val Asp Val Asn Pro Asp Ile Val Gln Ala Gln Val Leu Asp           
        35                  40                  45                        

ctg gcc gat gcc gct agc atc tcc cac act cct atc agg gcg gga tcg        192
Leu Ala Asp Ala Ala Ser Ile Ser His Thr Pro Ile Arg Ala Gly Ser           
    50                  55                  60                            

gtc gaa gaa gcc ggg cag gcc gat atc gtt gtg ata acc gcg ggt gcc        240
Val Glu Glu Ala Gly Gln Ala Asp Ile Val Val Ile Thr Ala Gly Ala           
65                  70                  75                  80            

aag cag cgc gag ggc gag ccg cgc acc aag ctg atc gaa cgg aat tac        288
Lys Gln Arg Glu Gly Glu Pro Arg Thr Lys Leu Ile Glu Arg Asn Tyr           
                85                  90                  95                

cgg gtc ctg cag agc atc atc ggc ggc atg cag ccc atc cgt cca gac        336
Arg Val Leu Gln Ser Ile Ile Gly Gly Met Gln Pro Ile Arg Pro Asp           
            100                 105                 110                   

gcc gtg atc ctc gtg gtc gct aac ccg gtc gac att ctg acc cat atc        384
Ala Val Ile Leu Val Val Ala Asn Pro Val Asp Ile Leu Thr His Ile           
        115                 120                 125                       

gct aag acc ctc tcc ggc ctg ccg ccc aac caa gtg atc ggc tcg ggt        432
Ala Lys Thr Leu Ser Gly Leu Pro Pro Asn Gln Val Ile Gly Ser Gly           
    130                 135                 140                           

acc tac ctg gac acg acg cgc ctg cgc gtg cac ctc ggc gac gtg ttc        480
Thr Tyr Leu Asp Thr Thr Arg Leu Arg Val His Leu Gly Asp Val Phe           
145                 150                 155                 160           

gac gtc aac ccg cag agc atc cac gcg ttc gtg ctg ggc gag cac ggc        528
Asp Val Asn Pro Gln Ser Ile His Ala Phe Val Leu Gly Glu His Gly           
                165                 170                 175               

gac tcg caa atg atc gcg tgg gaa gcc gcg tcg atc ggc ggt cag ccc        576
Asp Ser Gln Met Ile Ala Trp Glu Ala Ala Ser Ile Gly Gly Gln Pro           
            180                 185                 190                   

ctc acg agc ttc ccg gag ttc gcg aag ctg gac aag acc gcc atc tca        624
Leu Thr Ser Phe Pro Glu Phe Ala Lys Leu Asp Lys Thr Ala Ile Ser           
        195                 200                 205                       

aag gcc atc tcc ggc aag gcc atg gaa atc att cgg ttg aaa ggc gcc        672
Lys Ala Ile Ser Gly Lys Ala Met Glu Ile Ile Arg Leu Lys Gly Ala           
    210                 215                 220                           

acc ttc tac ggg atc ggg gcg tgt gcc gcc gat ctg gtg cat acc atc        720
Thr Phe Tyr Gly Ile Gly Ala Cys Ala Ala Asp Leu Val His Thr Ile           
225                 230                 235                 240           

atg ctg aac cgt aag agt gtc cat ccg gtg agt gtg tac gtc gag aaa        768
Met Leu Asn Arg Lys Ser Val His Pro Val Ser Val Tyr Val Glu Lys           
                245                 250                 255               

tat ggt gcg acg ttc tcc atg cct gcg aag ctg ggc tgg cgc ggc gta        816
Tyr Gly Ala Thr Phe Ser Met Pro Ala Lys Leu Gly Trp Arg Gly Val           
            260                 265                 270                   

gag caa atc tat gaa gtc ccc ttg acc gaa gaa gaa gaa gcc ctt ctg        864
Glu Gln Ile Tyr Glu Val Pro Leu Thr Glu Glu Glu Glu Ala Leu Leu           
        275                 280                 285                       

gtc aaa tcg gtc gag gcc ctc aag agc gtc gag tat tcc agt acc aag        912
Val Lys Ser Val Glu Ala Leu Lys Ser Val Glu Tyr Ser Ser Thr Lys           
    290                 295                 300                           

gtg ccc gag aaa aaa gtc cat gcg acc tcg ttt agc aag tcc aat tgc        960
Val Pro Glu Lys Lys Val His Ala Thr Ser Phe Ser Lys Ser Asn Cys           
305                 310                 315                 320           

taa                                                                    963


<210>  10
<211>  320
<212>  PRT
<213>  Artificial

<220>
<223>  Synthetic Construct

<400>  10

Met Val Leu His Ser Lys Val Ala Ile Val Gly Ala Gly Ala Val Gly 
1               5                   10                  15      


Ala Ser Thr Ala Tyr Ala Leu Met Phe Lys Asn Ile Cys Thr Glu Ile 
            20                  25                  30          


Ile Val Val Asp Val Asn Pro Asp Ile Val Gln Ala Gln Val Leu Asp 
        35                  40                  45              


Leu Ala Asp Ala Ala Ser Ile Ser His Thr Pro Ile Arg Ala Gly Ser 
    50                  55                  60                  


Val Glu Glu Ala Gly Gln Ala Asp Ile Val Val Ile Thr Ala Gly Ala 
65                  70                  75                  80  


Lys Gln Arg Glu Gly Glu Pro Arg Thr Lys Leu Ile Glu Arg Asn Tyr 
                85                  90                  95      


Arg Val Leu Gln Ser Ile Ile Gly Gly Met Gln Pro Ile Arg Pro Asp 
            100                 105                 110         


Ala Val Ile Leu Val Val Ala Asn Pro Val Asp Ile Leu Thr His Ile 
        115                 120                 125             


Ala Lys Thr Leu Ser Gly Leu Pro Pro Asn Gln Val Ile Gly Ser Gly 
    130                 135                 140                 


Thr Tyr Leu Asp Thr Thr Arg Leu Arg Val His Leu Gly Asp Val Phe 
145                 150                 155                 160 


Asp Val Asn Pro Gln Ser Ile His Ala Phe Val Leu Gly Glu His Gly 
                165                 170                 175     


Asp Ser Gln Met Ile Ala Trp Glu Ala Ala Ser Ile Gly Gly Gln Pro 
            180                 185                 190         


Leu Thr Ser Phe Pro Glu Phe Ala Lys Leu Asp Lys Thr Ala Ile Ser 
        195                 200                 205             


Lys Ala Ile Ser Gly Lys Ala Met Glu Ile Ile Arg Leu Lys Gly Ala 
    210                 215                 220                 


Thr Phe Tyr Gly Ile Gly Ala Cys Ala Ala Asp Leu Val His Thr Ile 
225                 230                 235                 240 


Met Leu Asn Arg Lys Ser Val His Pro Val Ser Val Tyr Val Glu Lys 
                245                 250                 255     


Tyr Gly Ala Thr Phe Ser Met Pro Ala Lys Leu Gly Trp Arg Gly Val 
            260                 265                 270         


Glu Gln Ile Tyr Glu Val Pro Leu Thr Glu Glu Glu Glu Ala Leu Leu 
        275                 280                 285             


Val Lys Ser Val Glu Ala Leu Lys Ser Val Glu Tyr Ser Ser Thr Lys 
    290                 295                 300                 


Val Pro Glu Lys Lys Val His Ala Thr Ser Phe Ser Lys Ser Asn Cys 
305                 310                 315                 320 


<210>  11
<211>  984
<212>  DNA
<213>  Artificial

<220>
<223>  Synthetic construct (Enterococcus faecalis LDH)


<220>
<221>  CDS
<222>  (1)..(984)

<400>  11
atg acc gcg gct gcc gga aat aag gac cac cag aaa gtg ata ctg gtc         48
Met Thr Ala Ala Ala Gly Asn Lys Asp His Gln Lys Val Ile Leu Val           
1               5                   10                  15                

ggg gac ggt gcc gtg ggc agc tcg tat gca ttc gcg ttg gtg acc cag         96
Gly Asp Gly Ala Val Gly Ser Ser Tyr Ala Phe Ala Leu Val Thr Gln           
            20                  25                  30                    

aac atc gcc caa gaa gtc ggc atc ata gat atc aac gtc ccc aag acc        144
Asn Ile Ala Gln Glu Val Gly Ile Ile Asp Ile Asn Val Pro Lys Thr           
        35                  40                  45                        

gag ggc gac gcc ctg gat ctc tcc cac gcc ctg gcc ttc acc agc ccc        192
Glu Gly Asp Ala Leu Asp Leu Ser His Ala Leu Ala Phe Thr Ser Pro           
    50                  55                  60                            

aaa aag atc tac gcg gcc acc tac gac gat tgc cat gac gcg gat ctc        240
Lys Lys Ile Tyr Ala Ala Thr Tyr Asp Asp Cys His Asp Ala Asp Leu           
65                  70                  75                  80            

gtt gtc ctg acc gcg ggt gcg ccg cag aag cct ggc gaa acg cga ctg        288
Val Val Leu Thr Ala Gly Ala Pro Gln Lys Pro Gly Glu Thr Arg Leu           
                85                  90                  95                

gat ctc gtc cat aag aac ttg aag atc aac aaa gaa atc gtc acc acc        336
Asp Leu Val His Lys Asn Leu Lys Ile Asn Lys Glu Ile Val Thr Thr           
            100                 105                 110                   

atc gtg gac tcg ggc ttc aac ggc atc ttc ctg gtg gcg gcc aac cca        384
Ile Val Asp Ser Gly Phe Asn Gly Ile Phe Leu Val Ala Ala Asn Pro           
        115                 120                 125                       

gta gac atc ctg acc tac tca acg tgg aag ttt agc ggg ttc ccg aag        432
Val Asp Ile Leu Thr Tyr Ser Thr Trp Lys Phe Ser Gly Phe Pro Lys           
    130                 135                 140                           

gaa cgg gtc atc ggg tcc ggc aca tcg ctt gac tcc gcg cgg ttc cgc        480
Glu Arg Val Ile Gly Ser Gly Thr Ser Leu Asp Ser Ala Arg Phe Arg           
145                 150                 155                 160           

cag gcc att gcg gag ctg gtc gac gtg gac gcc cgc aac gtg cac gcg        528
Gln Ala Ile Ala Glu Leu Val Asp Val Asp Ala Arg Asn Val His Ala           
                165                 170                 175               

tat atc ctc ggc gag cat ggc gac acc gag ttt ccc gtt tgg tcc cac        576
Tyr Ile Leu Gly Glu His Gly Asp Thr Glu Phe Pro Val Trp Ser His           
            180                 185                 190                   

gcc aat gtg gcg gga ttg cag atc tac gag tgg gta aag aat aat ccc        624
Ala Asn Val Ala Gly Leu Gln Ile Tyr Glu Trp Val Lys Asn Asn Pro           
        195                 200                 205                       

gat gtc gac gaa gaa gcc atg gtc aac ctc ttc ttc aac gtg cgc gat        672
Asp Val Asp Glu Glu Ala Met Val Asn Leu Phe Phe Asn Val Arg Asp           
    210                 215                 220                           

gca gct tat acg atc atc gag aaa aag gga gcc acg ttc tat ggc atc        720
Ala Ala Tyr Thr Ile Ile Glu Lys Lys Gly Ala Thr Phe Tyr Gly Ile           
225                 230                 235                 240           

gcc gtg gcg ctg gcc cgg atc acg aag gcc atc ctg aac gac gag aat        768
Ala Val Ala Leu Ala Arg Ile Thr Lys Ala Ile Leu Asn Asp Glu Asn           
                245                 250                 255               

tcc gtg ctc ccg ctg agt gtc tac ctg gaa ggg gag tac ggt cag aac        816
Ser Val Leu Pro Leu Ser Val Tyr Leu Glu Gly Glu Tyr Gly Gln Asn           
            260                 265                 270                   

gac atc tac atc ggc gca ccg gcc atc att aac cgt cag ggc gtc aaa        864
Asp Ile Tyr Ile Gly Ala Pro Ala Ile Ile Asn Arg Gln Gly Val Lys           
        275                 280                 285                       

caa gtg att gaa atc ccg ctg acc gac gcc gag caa gag aag atg gaa        912
Gln Val Ile Glu Ile Pro Leu Thr Asp Ala Glu Gln Glu Lys Met Glu           
    290                 295                 300                           

gcc agc gct tcg gcg ctg aaa gaa gtc atc gag act gcc ttc gcc aag        960
Ala Ser Ala Ser Ala Leu Lys Glu Val Ile Glu Thr Ala Phe Ala Lys           
305                 310                 315                 320           

ttc gag gcc gaa gaa gcg aag taa                                        984
Phe Glu Ala Glu Glu Ala Lys                                               
                325                                                       


<210>  12
<211>  327
<212>  PRT
<213>  Artificial

<220>
<223>  Synthetic Construct

<400>  12

Met Thr Ala Ala Ala Gly Asn Lys Asp His Gln Lys Val Ile Leu Val 
1               5                   10                  15      


Gly Asp Gly Ala Val Gly Ser Ser Tyr Ala Phe Ala Leu Val Thr Gln 
            20                  25                  30          


Asn Ile Ala Gln Glu Val Gly Ile Ile Asp Ile Asn Val Pro Lys Thr 
        35                  40                  45              


Glu Gly Asp Ala Leu Asp Leu Ser His Ala Leu Ala Phe Thr Ser Pro 
    50                  55                  60                  


Lys Lys Ile Tyr Ala Ala Thr Tyr Asp Asp Cys His Asp Ala Asp Leu 
65                  70                  75                  80  


Val Val Leu Thr Ala Gly Ala Pro Gln Lys Pro Gly Glu Thr Arg Leu 
                85                  90                  95      


Asp Leu Val His Lys Asn Leu Lys Ile Asn Lys Glu Ile Val Thr Thr 
            100                 105                 110         


Ile Val Asp Ser Gly Phe Asn Gly Ile Phe Leu Val Ala Ala Asn Pro 
        115                 120                 125             


Val Asp Ile Leu Thr Tyr Ser Thr Trp Lys Phe Ser Gly Phe Pro Lys 
    130                 135                 140                 


Glu Arg Val Ile Gly Ser Gly Thr Ser Leu Asp Ser Ala Arg Phe Arg 
145                 150                 155                 160 


Gln Ala Ile Ala Glu Leu Val Asp Val Asp Ala Arg Asn Val His Ala 
                165                 170                 175     


Tyr Ile Leu Gly Glu His Gly Asp Thr Glu Phe Pro Val Trp Ser His 
            180                 185                 190         


Ala Asn Val Ala Gly Leu Gln Ile Tyr Glu Trp Val Lys Asn Asn Pro 
        195                 200                 205             


Asp Val Asp Glu Glu Ala Met Val Asn Leu Phe Phe Asn Val Arg Asp 
    210                 215                 220                 


Ala Ala Tyr Thr Ile Ile Glu Lys Lys Gly Ala Thr Phe Tyr Gly Ile 
225                 230                 235                 240 


Ala Val Ala Leu Ala Arg Ile Thr Lys Ala Ile Leu Asn Asp Glu Asn 
                245                 250                 255     


Ser Val Leu Pro Leu Ser Val Tyr Leu Glu Gly Glu Tyr Gly Gln Asn 
            260                 265                 270         


Asp Ile Tyr Ile Gly Ala Pro Ala Ile Ile Asn Arg Gln Gly Val Lys 
        275                 280                 285             


Gln Val Ile Glu Ile Pro Leu Thr Asp Ala Glu Gln Glu Lys Met Glu 
    290                 295                 300                 


Ala Ser Ala Ser Ala Leu Lys Glu Val Ile Glu Thr Ala Phe Ala Lys 
305                 310                 315                 320 


Phe Glu Ala Glu Glu Ala Lys 
                325         


<210>  13
<211>  939
<212>  DNA
<213>  Artificial

<220>
<223>  Synthetic construct (Lactobacillus casei LDH)


<220>
<221>  CDS
<222>  (1)..(939)

<400>  13
atg cgc aat aac ggg aac atc att ctt ata ggt gac ggt gcc atc ggt         48
Met Arg Asn Asn Gly Asn Ile Ile Leu Ile Gly Asp Gly Ala Ile Gly           
1               5                   10                  15                

agt tct tat gcc ttc aac tgc ctg acc acc ggc gtc ggc cag tcc ctg         96
Ser Ser Tyr Ala Phe Asn Cys Leu Thr Thr Gly Val Gly Gln Ser Leu           
            20                  25                  30                    

ggg ata atc gac gtg aac gag aag cgc gta cag ggc gac gtc gag gac        144
Gly Ile Ile Asp Val Asn Glu Lys Arg Val Gln Gly Asp Val Glu Asp           
        35                  40                  45                        

ttg agc gac gcc ctg ccc tac act tcg cag aag aac atc tac gct gcg        192
Leu Ser Asp Ala Leu Pro Tyr Thr Ser Gln Lys Asn Ile Tyr Ala Ala           
    50                  55                  60                            

tcc tac gaa gat tgc aaa tat gcc gac att atc gtg atc acg gca ggc        240
Ser Tyr Glu Asp Cys Lys Tyr Ala Asp Ile Ile Val Ile Thr Ala Gly           
65                  70                  75                  80            

atc gcc cag aag ccc gga cag acc cgg ttg cag ctc ctg gca atc aac        288
Ile Ala Gln Lys Pro Gly Gln Thr Arg Leu Gln Leu Leu Ala Ile Asn           
                85                  90                  95                

gcg aag att atg aaa gaa atc acc cat aac atc atg gcc tcg ggt ttc        336
Ala Lys Ile Met Lys Glu Ile Thr His Asn Ile Met Ala Ser Gly Phe           
            100                 105                 110                   

aat ggc ttc atc ctg gtc gcc agc aac ccg gtg gac gtc ttg gcg gag        384
Asn Gly Phe Ile Leu Val Ala Ser Asn Pro Val Asp Val Leu Ala Glu           
        115                 120                 125                       

ctg gtg ctc cag gaa tcg ggc ctg ccc cgg aac caa gtc ctg ggc tcg        432
Leu Val Leu Gln Glu Ser Gly Leu Pro Arg Asn Gln Val Leu Gly Ser           
    130                 135                 140                           

ggc acc gcc ctc gac tcg gcg cgt ctg cgg agc gag atc ggg ctg cgc        480
Gly Thr Ala Leu Asp Ser Ala Arg Leu Arg Ser Glu Ile Gly Leu Arg           
145                 150                 155                 160           

tac aat gtc gac gca cgg atc gtc cac ggg tac atc atg ggc gag cac        528
Tyr Asn Val Asp Ala Arg Ile Val His Gly Tyr Ile Met Gly Glu His           
                165                 170                 175               

ggc gat tcc gag ttc ccg gtg tgg gac tac acc aat atc ggc ggc aag        576
Gly Asp Ser Glu Phe Pro Val Trp Asp Tyr Thr Asn Ile Gly Gly Lys           
            180                 185                 190                   

ccg atc ctc gat tgg atc ccg aag gac cgc cag gac aaa gat ctc cct        624
Pro Ile Leu Asp Trp Ile Pro Lys Asp Arg Gln Asp Lys Asp Leu Pro           
        195                 200                 205                       

gat atc tcc gaa agg gtt aag aca gcg gcc tat gga att atc gag aag        672
Asp Ile Ser Glu Arg Val Lys Thr Ala Ala Tyr Gly Ile Ile Glu Lys           
    210                 215                 220                           

aaa ggg gcc acg ttt tac ggc atc gcc gcg tcc ctg acc cgt ttg acg        720
Lys Gly Ala Thr Phe Tyr Gly Ile Ala Ala Ser Leu Thr Arg Leu Thr           
225                 230                 235                 240           

tca gcg ttc ctg aac gac gat cga gcg gcc ttc gcc atg agc gtg cat        768
Ser Ala Phe Leu Asn Asp Asp Arg Ala Ala Phe Ala Met Ser Val His           
                245                 250                 255               

ctg gaa ggc gaa tat ggc ctt agc gga gtg tcg atc ggc gtc ccg gtg        816
Leu Glu Gly Glu Tyr Gly Leu Ser Gly Val Ser Ile Gly Val Pro Val           
            260                 265                 270                   

atc ctg ggc gcc aac ggc ctg gag cgc atc atc gaa ctc gac ctg aat        864
Ile Leu Gly Ala Asn Gly Leu Glu Arg Ile Ile Glu Leu Asp Leu Asn           
        275                 280                 285                       

cca gag gat cac aag cgc ctg gcc gac agc gct gcg atc ctc aag gaa        912
Pro Glu Asp His Lys Arg Leu Ala Asp Ser Ala Ala Ile Leu Lys Glu           
    290                 295                 300                           

aac ctg aaa aag gcg caa gaa gcc taa                                    939
Asn Leu Lys Lys Ala Gln Glu Ala                                           
305                 310                                                   


<210>  14
<211>  312
<212>  PRT
<213>  Artificial

<220>
<223>  Synthetic Construct

<400>  14

Met Arg Asn Asn Gly Asn Ile Ile Leu Ile Gly Asp Gly Ala Ile Gly 
1               5                   10                  15      


Ser Ser Tyr Ala Phe Asn Cys Leu Thr Thr Gly Val Gly Gln Ser Leu 
            20                  25                  30          


Gly Ile Ile Asp Val Asn Glu Lys Arg Val Gln Gly Asp Val Glu Asp 
        35                  40                  45              


Leu Ser Asp Ala Leu Pro Tyr Thr Ser Gln Lys Asn Ile Tyr Ala Ala 
    50                  55                  60                  


Ser Tyr Glu Asp Cys Lys Tyr Ala Asp Ile Ile Val Ile Thr Ala Gly 
65                  70                  75                  80  


Ile Ala Gln Lys Pro Gly Gln Thr Arg Leu Gln Leu Leu Ala Ile Asn 
                85                  90                  95      


Ala Lys Ile Met Lys Glu Ile Thr His Asn Ile Met Ala Ser Gly Phe 
            100                 105                 110         


Asn Gly Phe Ile Leu Val Ala Ser Asn Pro Val Asp Val Leu Ala Glu 
        115                 120                 125             


Leu Val Leu Gln Glu Ser Gly Leu Pro Arg Asn Gln Val Leu Gly Ser 
    130                 135                 140                 


Gly Thr Ala Leu Asp Ser Ala Arg Leu Arg Ser Glu Ile Gly Leu Arg 
145                 150                 155                 160 


Tyr Asn Val Asp Ala Arg Ile Val His Gly Tyr Ile Met Gly Glu His 
                165                 170                 175     


Gly Asp Ser Glu Phe Pro Val Trp Asp Tyr Thr Asn Ile Gly Gly Lys 
            180                 185                 190         


Pro Ile Leu Asp Trp Ile Pro Lys Asp Arg Gln Asp Lys Asp Leu Pro 
        195                 200                 205             


Asp Ile Ser Glu Arg Val Lys Thr Ala Ala Tyr Gly Ile Ile Glu Lys 
    210                 215                 220                 


Lys Gly Ala Thr Phe Tyr Gly Ile Ala Ala Ser Leu Thr Arg Leu Thr 
225                 230                 235                 240 


Ser Ala Phe Leu Asn Asp Asp Arg Ala Ala Phe Ala Met Ser Val His 
                245                 250                 255     


Leu Glu Gly Glu Tyr Gly Leu Ser Gly Val Ser Ile Gly Val Pro Val 
            260                 265                 270         


Ile Leu Gly Ala Asn Gly Leu Glu Arg Ile Ile Glu Leu Asp Leu Asn 
        275                 280                 285             


Pro Glu Asp His Lys Arg Leu Ala Asp Ser Ala Ala Ile Leu Lys Glu 
    290                 295                 300                 


Asn Leu Lys Lys Ala Gln Glu Ala 
305                 310         


<210>  15
<211>  957
<212>  DNA
<213>  Artificial

<220>
<223>  Synthetic construct (Bacillus megaterium LDH)


<220>
<221>  CDS
<222>  (1)..(957)

<400>  15
atg aaa acg cag ttc acc ccc aag aca cga aaa gta gca gtt ata ggc         48
Met Lys Thr Gln Phe Thr Pro Lys Thr Arg Lys Val Ala Val Ile Gly           
1               5                   10                  15                

acc ggc ttc gtg ggc tcc tcc tac gcg ttc tcg atg gtc aat cag ggg         96
Thr Gly Phe Val Gly Ser Ser Tyr Ala Phe Ser Met Val Asn Gln Gly           
            20                  25                  30                    

atc gcg aac gaa ctg gtc ctg atc gac atg aac aag gaa aag gcc gag        144
Ile Ala Asn Glu Leu Val Leu Ile Asp Met Asn Lys Glu Lys Ala Glu           
        35                  40                  45                        

ggc gaa gcc cgg gat atc aac cat ggc atg cct ttt gcc acc ccg atg        192
Gly Glu Ala Arg Asp Ile Asn His Gly Met Pro Phe Ala Thr Pro Met           
    50                  55                  60                            

aag att tgg gcc gga gat tac aag gac tgc gcg gac gcg gac ctg gcc        240
Lys Ile Trp Ala Gly Asp Tyr Lys Asp Cys Ala Asp Ala Asp Leu Ala           
65                  70                  75                  80            

gtg atc acc gcg ggt gcg aat cag gct ccg ggt gaa acc cgg ctg gac        288
Val Ile Thr Ala Gly Ala Asn Gln Ala Pro Gly Glu Thr Arg Leu Asp           
                85                  90                  95                

ctc gtc gag aaa aat gtc aag atc ttc gag tgc atc gtt aaa gac atc        336
Leu Val Glu Lys Asn Val Lys Ile Phe Glu Cys Ile Val Lys Asp Ile           
            100                 105                 110                   

atg aac tcg ggg ttc gac ggc atc atc ctg gtc gcc acc aac ccg gtc        384
Met Asn Ser Gly Phe Asp Gly Ile Ile Leu Val Ala Thr Asn Pro Val           
        115                 120                 125                       

gat atc ctg gcc cat gtc acg caa aag gtg agc ggc ctg ccc aac gag        432
Asp Ile Leu Ala His Val Thr Gln Lys Val Ser Gly Leu Pro Asn Glu           
    130                 135                 140                           

cgg gtc att ggt tcg ggc acc atc ttg gac acg gcc cgt ttc cgc tat        480
Arg Val Ile Gly Ser Gly Thr Ile Leu Asp Thr Ala Arg Phe Arg Tyr           
145                 150                 155                 160           

ctc ttg agc gat tac ttc gaa gtg gat tcc cgc aac gtc cac gcg tac        528
Leu Leu Ser Asp Tyr Phe Glu Val Asp Ser Arg Asn Val His Ala Tyr           
                165                 170                 175               

atc atg ggc gag cac ggg gac acg gaa ttc ccg gtc tgg tcg cac gcc        576
Ile Met Gly Glu His Gly Asp Thr Glu Phe Pro Val Trp Ser His Ala           
            180                 185                 190                   

cag atc ggc gga gtg aag ctg gag cac ttt atc aat acg gca gct atc        624
Gln Ile Gly Gly Val Lys Leu Glu His Phe Ile Asn Thr Ala Ala Ile           
        195                 200                 205                       

gaa aaa gag cca gac atg cag cac ctg ttc gag cag acc cgg gac gcg        672
Glu Lys Glu Pro Asp Met Gln His Leu Phe Glu Gln Thr Arg Asp Ala           
    210                 215                 220                           

gcc tac cac atc att aat cgc aag ggc gcg acg tac tat gga atc gcc        720
Ala Tyr His Ile Ile Asn Arg Lys Gly Ala Thr Tyr Tyr Gly Ile Ala           
225                 230                 235                 240           

atg ggg ctg gtc agg atc acc aag gcc atc ctt gac gat gag aac agc        768
Met Gly Leu Val Arg Ile Thr Lys Ala Ile Leu Asp Asp Glu Asn Ser           
                245                 250                 255               

atc ctc acc gtg agt gcg ctg ttg gaa ggc cag tat ggc ata tca gac        816
Ile Leu Thr Val Ser Ala Leu Leu Glu Gly Gln Tyr Gly Ile Ser Asp           
            260                 265                 270                   

gtg tat atc ggt gtg ccc gcc att atc aac aag aac ggc gtg cgg cag        864
Val Tyr Ile Gly Val Pro Ala Ile Ile Asn Lys Asn Gly Val Arg Gln           
        275                 280                 285                       

atc atc gag ctg aac ctg acc ccg cat gaa caa cag cag ctc gaa cat        912
Ile Ile Glu Leu Asn Leu Thr Pro His Glu Gln Gln Gln Leu Glu His           
    290                 295                 300                           

agc gcc tcc atc ctc aag cag act cgc gat cgc gcc ttc gtg taa            957
Ser Ala Ser Ile Leu Lys Gln Thr Arg Asp Arg Ala Phe Val                   
305                 310                 315                               


<210>  16
<211>  318
<212>  PRT
<213>  Artificial

<220>
<223>  Synthetic Construct

<400>  16

Met Lys Thr Gln Phe Thr Pro Lys Thr Arg Lys Val Ala Val Ile Gly 
1               5                   10                  15      


Thr Gly Phe Val Gly Ser Ser Tyr Ala Phe Ser Met Val Asn Gln Gly 
            20                  25                  30          


Ile Ala Asn Glu Leu Val Leu Ile Asp Met Asn Lys Glu Lys Ala Glu 
        35                  40                  45              


Gly Glu Ala Arg Asp Ile Asn His Gly Met Pro Phe Ala Thr Pro Met 
    50                  55                  60                  


Lys Ile Trp Ala Gly Asp Tyr Lys Asp Cys Ala Asp Ala Asp Leu Ala 
65                  70                  75                  80  


Val Ile Thr Ala Gly Ala Asn Gln Ala Pro Gly Glu Thr Arg Leu Asp 
                85                  90                  95      


Leu Val Glu Lys Asn Val Lys Ile Phe Glu Cys Ile Val Lys Asp Ile 
            100                 105                 110         


Met Asn Ser Gly Phe Asp Gly Ile Ile Leu Val Ala Thr Asn Pro Val 
        115                 120                 125             


Asp Ile Leu Ala His Val Thr Gln Lys Val Ser Gly Leu Pro Asn Glu 
    130                 135                 140                 


Arg Val Ile Gly Ser Gly Thr Ile Leu Asp Thr Ala Arg Phe Arg Tyr 
145                 150                 155                 160 


Leu Leu Ser Asp Tyr Phe Glu Val Asp Ser Arg Asn Val His Ala Tyr 
                165                 170                 175     


Ile Met Gly Glu His Gly Asp Thr Glu Phe Pro Val Trp Ser His Ala 
            180                 185                 190         


Gln Ile Gly Gly Val Lys Leu Glu His Phe Ile Asn Thr Ala Ala Ile 
        195                 200                 205             


Glu Lys Glu Pro Asp Met Gln His Leu Phe Glu Gln Thr Arg Asp Ala 
    210                 215                 220                 


Ala Tyr His Ile Ile Asn Arg Lys Gly Ala Thr Tyr Tyr Gly Ile Ala 
225                 230                 235                 240 


Met Gly Leu Val Arg Ile Thr Lys Ala Ile Leu Asp Asp Glu Asn Ser 
                245                 250                 255     


Ile Leu Thr Val Ser Ala Leu Leu Glu Gly Gln Tyr Gly Ile Ser Asp 
            260                 265                 270         


Val Tyr Ile Gly Val Pro Ala Ile Ile Asn Lys Asn Gly Val Arg Gln 
        275                 280                 285             


Ile Ile Glu Leu Asn Leu Thr Pro His Glu Gln Gln Gln Leu Glu His 
    290                 295                 300                 


Ser Ala Ser Ile Leu Lys Gln Thr Arg Asp Arg Ala Phe Val 
305                 310                 315             


<210>  17
<211>  957
<212>  DNA
<213>  Artificial

<220>
<223>  Synthetic construct (Taeniopygia guttata LDH)


<220>
<221>  CDS
<222>  (1)..(957)

<400>  17
atg aaa acg cag ttc acc ccc aag aca cga aaa gta gca gtt ata ggc         48
Met Lys Thr Gln Phe Thr Pro Lys Thr Arg Lys Val Ala Val Ile Gly           
1               5                   10                  15                

acc ggc ttc gtg ggc tcc tcc tac gcg ttc tcg atg gtc aat cag ggg         96
Thr Gly Phe Val Gly Ser Ser Tyr Ala Phe Ser Met Val Asn Gln Gly           
            20                  25                  30                    

atc gcg aac gaa ctg gtc ctg atc gac atg aac aag gaa aag gcc gag        144
Ile Ala Asn Glu Leu Val Leu Ile Asp Met Asn Lys Glu Lys Ala Glu           
        35                  40                  45                        

ggc gaa gcc cgg gat atc aac cat ggc atg cct ttt gcc acc ccg atg        192
Gly Glu Ala Arg Asp Ile Asn His Gly Met Pro Phe Ala Thr Pro Met           
    50                  55                  60                            

aag att tgg gcc gga gat tac aag gac tgc gcg gac gcg gac ctg gcc        240
Lys Ile Trp Ala Gly Asp Tyr Lys Asp Cys Ala Asp Ala Asp Leu Ala           
65                  70                  75                  80            

gtg atc acc gcg ggt gcg aat cag gct ccg ggt gaa acc cgg ctg gac        288
Val Ile Thr Ala Gly Ala Asn Gln Ala Pro Gly Glu Thr Arg Leu Asp           
                85                  90                  95                

ctc gtc gag aaa aat gtc aag atc ttc gag tgc atc gtt aaa gac atc        336
Leu Val Glu Lys Asn Val Lys Ile Phe Glu Cys Ile Val Lys Asp Ile           
            100                 105                 110                   

atg aac tcg ggg ttc gac ggc atc atc ctg gtc gcc acc aac ccg gtc        384
Met Asn Ser Gly Phe Asp Gly Ile Ile Leu Val Ala Thr Asn Pro Val           
        115                 120                 125                       

gat atc ctg gcc cat gtc acg caa aag gtg agc ggc ctg ccc aac gag        432
Asp Ile Leu Ala His Val Thr Gln Lys Val Ser Gly Leu Pro Asn Glu           
    130                 135                 140                           

cgg gtc att ggt tcg ggc acc atc ttg gac acg gcc cgt ttc cgc tat        480
Arg Val Ile Gly Ser Gly Thr Ile Leu Asp Thr Ala Arg Phe Arg Tyr           
145                 150                 155                 160           

ctc ttg agc gat tac ttc gaa gtg gat tcc cgc aac gtc cac gcg tac        528
Leu Leu Ser Asp Tyr Phe Glu Val Asp Ser Arg Asn Val His Ala Tyr           
                165                 170                 175               

atc atg ggc gag cac ggg gac acg gaa ttc ccg gtc tgg tcg cac gcc        576
Ile Met Gly Glu His Gly Asp Thr Glu Phe Pro Val Trp Ser His Ala           
            180                 185                 190                   

cag atc ggc gga gtg aag ctg gag cac ttt atc aat acg gca gct atc        624
Gln Ile Gly Gly Val Lys Leu Glu His Phe Ile Asn Thr Ala Ala Ile           
        195                 200                 205                       

gaa aaa gag cca gac atg cag cac ctg ttc gag cag acc cgg gac gcg        672
Glu Lys Glu Pro Asp Met Gln His Leu Phe Glu Gln Thr Arg Asp Ala           
    210                 215                 220                           

gcc tac cac atc att aat cgc aag ggc gcg acg tac tat gga atc gcc        720
Ala Tyr His Ile Ile Asn Arg Lys Gly Ala Thr Tyr Tyr Gly Ile Ala           
225                 230                 235                 240           

atg ggg ctg gtc agg atc acc aag gcc atc ctt gac gat gag aac agc        768
Met Gly Leu Val Arg Ile Thr Lys Ala Ile Leu Asp Asp Glu Asn Ser           
                245                 250                 255               

atc ctc acc gtg agt gcg ctg ttg gaa ggc cag tat ggc ata tca gac        816
Ile Leu Thr Val Ser Ala Leu Leu Glu Gly Gln Tyr Gly Ile Ser Asp           
            260                 265                 270                   

gtg tat atc ggt gtg ccc gcc att atc aac aag aac ggc gtg cgg cag        864
Val Tyr Ile Gly Val Pro Ala Ile Ile Asn Lys Asn Gly Val Arg Gln           
        275                 280                 285                       

atc atc gag ctg aac ctg acc ccg cat gaa caa cag cag ctc gaa cat        912
Ile Ile Glu Leu Asn Leu Thr Pro His Glu Gln Gln Gln Leu Glu His           
    290                 295                 300                           

agc gcc tcc atc ctc aag cag act cgc gat cgc gcc ttc gtg taa            957
Ser Ala Ser Ile Leu Lys Gln Thr Arg Asp Arg Ala Phe Val                   
305                 310                 315                               


<210>  18
<211>  318
<212>  PRT
<213>  Artificial

<220>
<223>  Synthetic Construct

<400>  18

Met Lys Thr Gln Phe Thr Pro Lys Thr Arg Lys Val Ala Val Ile Gly 
1               5                   10                  15      


Thr Gly Phe Val Gly Ser Ser Tyr Ala Phe Ser Met Val Asn Gln Gly 
            20                  25                  30          


Ile Ala Asn Glu Leu Val Leu Ile Asp Met Asn Lys Glu Lys Ala Glu 
        35                  40                  45              


Gly Glu Ala Arg Asp Ile Asn His Gly Met Pro Phe Ala Thr Pro Met 
    50                  55                  60                  


Lys Ile Trp Ala Gly Asp Tyr Lys Asp Cys Ala Asp Ala Asp Leu Ala 
65                  70                  75                  80  


Val Ile Thr Ala Gly Ala Asn Gln Ala Pro Gly Glu Thr Arg Leu Asp 
                85                  90                  95      


Leu Val Glu Lys Asn Val Lys Ile Phe Glu Cys Ile Val Lys Asp Ile 
            100                 105                 110         


Met Asn Ser Gly Phe Asp Gly Ile Ile Leu Val Ala Thr Asn Pro Val 
        115                 120                 125             


Asp Ile Leu Ala His Val Thr Gln Lys Val Ser Gly Leu Pro Asn Glu 
    130                 135                 140                 


Arg Val Ile Gly Ser Gly Thr Ile Leu Asp Thr Ala Arg Phe Arg Tyr 
145                 150                 155                 160 


Leu Leu Ser Asp Tyr Phe Glu Val Asp Ser Arg Asn Val His Ala Tyr 
                165                 170                 175     


Ile Met Gly Glu His Gly Asp Thr Glu Phe Pro Val Trp Ser His Ala 
            180                 185                 190         


Gln Ile Gly Gly Val Lys Leu Glu His Phe Ile Asn Thr Ala Ala Ile 
        195                 200                 205             


Glu Lys Glu Pro Asp Met Gln His Leu Phe Glu Gln Thr Arg Asp Ala 
    210                 215                 220                 


Ala Tyr His Ile Ile Asn Arg Lys Gly Ala Thr Tyr Tyr Gly Ile Ala 
225                 230                 235                 240 


Met Gly Leu Val Arg Ile Thr Lys Ala Ile Leu Asp Asp Glu Asn Ser 
                245                 250                 255     


Ile Leu Thr Val Ser Ala Leu Leu Glu Gly Gln Tyr Gly Ile Ser Asp 
            260                 265                 270         


Val Tyr Ile Gly Val Pro Ala Ile Ile Asn Lys Asn Gly Val Arg Gln 
        275                 280                 285             


Ile Ile Glu Leu Asn Leu Thr Pro His Glu Gln Gln Gln Leu Glu His 
    290                 295                 300                 


Ser Ala Ser Ile Leu Lys Gln Thr Arg Asp Arg Ala Phe Val 
305                 310                 315             


<210>  19
<211>  963
<212>  DNA
<213>  Artificial

<220>
<223>  Synthetic construct (Lactobacillus plantarum LDH)


<220>
<221>  CDS
<222>  (1)..(963)

<400>  19
atg tcg tcg atg cct aac cat cag aaa gtc gtc ctg gtg ggc gac gga         48
Met Ser Ser Met Pro Asn His Gln Lys Val Val Leu Val Gly Asp Gly           
1               5                   10                  15                

gcg gtc ggc agc tca tac gcc ttc gcg atg gcg caa cag gga atc gcg         96
Ala Val Gly Ser Ser Tyr Ala Phe Ala Met Ala Gln Gln Gly Ile Ala           
            20                  25                  30                    

gaa gaa ttc gtc atc gtc gac gtg gtg aag gac cgc acc aag ggc gac        144
Glu Glu Phe Val Ile Val Asp Val Val Lys Asp Arg Thr Lys Gly Asp           
        35                  40                  45                        

gcc ttg gac ctc gaa gat gca cag gcc ttc acg gcc ccg aag aaa atc        192
Ala Leu Asp Leu Glu Asp Ala Gln Ala Phe Thr Ala Pro Lys Lys Ile           
    50                  55                  60                            

tac agc ggc gag tat agc gac tgc aaa gac gcg gac ctc gtg gtc ata        240
Tyr Ser Gly Glu Tyr Ser Asp Cys Lys Asp Ala Asp Leu Val Val Ile           
65                  70                  75                  80            

acc gcg gga gcg cca cag aag ccc gga gaa tcg agg ctg gac ctt gtc        288
Thr Ala Gly Ala Pro Gln Lys Pro Gly Glu Ser Arg Leu Asp Leu Val           
                85                  90                  95                

aac aaa aac ttg aac atc ctg tcc tcg atc gtg aag ccc gtg gta gac        336
Asn Lys Asn Leu Asn Ile Leu Ser Ser Ile Val Lys Pro Val Val Asp           
            100                 105                 110                   

tcc ggg ttc gac ggc atc ttc ctg gtg gcc gcc aac ccc gtc gac atc        384
Ser Gly Phe Asp Gly Ile Phe Leu Val Ala Ala Asn Pro Val Asp Ile           
        115                 120                 125                       

ctc acc tat gcg acc tgg aag ttc agc ggg ttt ccg aag gac cgg gtc        432
Leu Thr Tyr Ala Thr Trp Lys Phe Ser Gly Phe Pro Lys Asp Arg Val           
    130                 135                 140                           

att ggc agt ggg acg tcg ctg gat agc tcg cgt ctg cga gtt gct ctg        480
Ile Gly Ser Gly Thr Ser Leu Asp Ser Ser Arg Leu Arg Val Ala Leu           
145                 150                 155                 160           

ggg aag caa ttc aac gtg gat ccg cgc tct gtg gat gcg tat atc atg        528
Gly Lys Gln Phe Asn Val Asp Pro Arg Ser Val Asp Ala Tyr Ile Met           
                165                 170                 175               

ggc gag cac ggc gat agt gag ttc gcc gca tat tcc acc gcc acg atc        576
Gly Glu His Gly Asp Ser Glu Phe Ala Ala Tyr Ser Thr Ala Thr Ile           
            180                 185                 190                   

ggc act cgg ccc gtg cgc gac gtt gcg aag gaa cag ggc gta tcc gac        624
Gly Thr Arg Pro Val Arg Asp Val Ala Lys Glu Gln Gly Val Ser Asp           
        195                 200                 205                       

gag gac ctg gcc aag ctg gaa gat ggc gtc cgc aac aag gcc tac gac        672
Glu Asp Leu Ala Lys Leu Glu Asp Gly Val Arg Asn Lys Ala Tyr Asp           
    210                 215                 220                           

atc atc aat ctc aag ggc gcg acc ttc tac ggt att ggt acc gcc ctg        720
Ile Ile Asn Leu Lys Gly Ala Thr Phe Tyr Gly Ile Gly Thr Ala Leu           
225                 230                 235                 240           

atg cgg atc tcc aag gcc atc ctg cgc gat gag aac gcc gtg ttg ccg        768
Met Arg Ile Ser Lys Ala Ile Leu Arg Asp Glu Asn Ala Val Leu Pro           
                245                 250                 255               

gtg ggg gct tac atg gat ggc cag tac ggc ctg aac gat atc tac atc        816
Val Gly Ala Tyr Met Asp Gly Gln Tyr Gly Leu Asn Asp Ile Tyr Ile           
            260                 265                 270                   

ggc aca ccg gcc gtc atc ggt ggc acc ggt ctg aag cag atc atc gag        864
Gly Thr Pro Ala Val Ile Gly Gly Thr Gly Leu Lys Gln Ile Ile Glu           
        275                 280                 285                       

agc ccg ctg tcc gcc gac gag ctg aaa aag atg cag gac agc gcc gca        912
Ser Pro Leu Ser Ala Asp Glu Leu Lys Lys Met Gln Asp Ser Ala Ala           
    290                 295                 300                           

acg ctc aaa aaa gtc ctc aat gat ggc ctg gcc gaa ctg gag aat aag        960
Thr Leu Lys Lys Val Leu Asn Asp Gly Leu Ala Glu Leu Glu Asn Lys           
305                 310                 315                 320           

taa                                                                    963


<210>  20
<211>  320
<212>  PRT
<213>  Artificial

<220>
<223>  Synthetic Construct

<400>  20

Met Ser Ser Met Pro Asn His Gln Lys Val Val Leu Val Gly Asp Gly 
1               5                   10                  15      


Ala Val Gly Ser Ser Tyr Ala Phe Ala Met Ala Gln Gln Gly Ile Ala 
            20                  25                  30          


Glu Glu Phe Val Ile Val Asp Val Val Lys Asp Arg Thr Lys Gly Asp 
        35                  40                  45              


Ala Leu Asp Leu Glu Asp Ala Gln Ala Phe Thr Ala Pro Lys Lys Ile 
    50                  55                  60                  


Tyr Ser Gly Glu Tyr Ser Asp Cys Lys Asp Ala Asp Leu Val Val Ile 
65                  70                  75                  80  


Thr Ala Gly Ala Pro Gln Lys Pro Gly Glu Ser Arg Leu Asp Leu Val 
                85                  90                  95      


Asn Lys Asn Leu Asn Ile Leu Ser Ser Ile Val Lys Pro Val Val Asp 
            100                 105                 110         


Ser Gly Phe Asp Gly Ile Phe Leu Val Ala Ala Asn Pro Val Asp Ile 
        115                 120                 125             


Leu Thr Tyr Ala Thr Trp Lys Phe Ser Gly Phe Pro Lys Asp Arg Val 
    130                 135                 140                 


Ile Gly Ser Gly Thr Ser Leu Asp Ser Ser Arg Leu Arg Val Ala Leu 
145                 150                 155                 160 


Gly Lys Gln Phe Asn Val Asp Pro Arg Ser Val Asp Ala Tyr Ile Met 
                165                 170                 175     


Gly Glu His Gly Asp Ser Glu Phe Ala Ala Tyr Ser Thr Ala Thr Ile 
            180                 185                 190         


Gly Thr Arg Pro Val Arg Asp Val Ala Lys Glu Gln Gly Val Ser Asp 
        195                 200                 205             


Glu Asp Leu Ala Lys Leu Glu Asp Gly Val Arg Asn Lys Ala Tyr Asp 
    210                 215                 220                 


Ile Ile Asn Leu Lys Gly Ala Thr Phe Tyr Gly Ile Gly Thr Ala Leu 
225                 230                 235                 240 


Met Arg Ile Ser Lys Ala Ile Leu Arg Asp Glu Asn Ala Val Leu Pro 
                245                 250                 255     


Val Gly Ala Tyr Met Asp Gly Gln Tyr Gly Leu Asn Asp Ile Tyr Ile 
            260                 265                 270         


Gly Thr Pro Ala Val Ile Gly Gly Thr Gly Leu Lys Gln Ile Ile Glu 
        275                 280                 285             


Ser Pro Leu Ser Ala Asp Glu Leu Lys Lys Met Gln Asp Ser Ala Ala 
    290                 295                 300                 


Thr Leu Lys Lys Val Leu Asn Asp Gly Leu Ala Glu Leu Glu Asn Lys 
305                 310                 315                 320 


<210>  21
<211>  963
<212>  DNA
<213>  Artificial

<220>
<223>  Synthetic construct (Lactobacillus acidophilus LDH)


<220>
<221>  CDS
<222>  (1)..(963)

<400>  21
atg tcg tcg atg cct aac cat cag aaa gtc gtc ctg gtg ggc gac gga         48
Met Ser Ser Met Pro Asn His Gln Lys Val Val Leu Val Gly Asp Gly           
1               5                   10                  15                

gcg gtc ggc agc tca tac gcc ttc gcg atg gcg caa cag gga atc gcg         96
Ala Val Gly Ser Ser Tyr Ala Phe Ala Met Ala Gln Gln Gly Ile Ala           
            20                  25                  30                    

gaa gaa ttc gtc atc gtc gac gtg gtg aag gac cgc acc aag ggc gac        144
Glu Glu Phe Val Ile Val Asp Val Val Lys Asp Arg Thr Lys Gly Asp           
        35                  40                  45                        

gcc ttg gac ctc gaa gat gca cag gcc ttc acg gcc ccg aag aaa atc        192
Ala Leu Asp Leu Glu Asp Ala Gln Ala Phe Thr Ala Pro Lys Lys Ile           
    50                  55                  60                            

tac agc ggc gag tat agc gac tgc aaa gac gcg gac ctc gtg gtc ata        240
Tyr Ser Gly Glu Tyr Ser Asp Cys Lys Asp Ala Asp Leu Val Val Ile           
65                  70                  75                  80            

acc gcg gga gcg cca cag aag ccc gga gaa tcg agg ctg gac ctt gtc        288
Thr Ala Gly Ala Pro Gln Lys Pro Gly Glu Ser Arg Leu Asp Leu Val           
                85                  90                  95                

aac aaa aac ttg aac atc ctg tcc tcg atc gtg aag ccc gtg gta gac        336
Asn Lys Asn Leu Asn Ile Leu Ser Ser Ile Val Lys Pro Val Val Asp           
            100                 105                 110                   

tcc ggg ttc gac ggc atc ttc ctg gtg gcc gcc aac ccc gtc gac atc        384
Ser Gly Phe Asp Gly Ile Phe Leu Val Ala Ala Asn Pro Val Asp Ile           
        115                 120                 125                       

ctc acc tat gcg acc tgg aag ttc agc ggg ttt ccg aag gac cgg gtc        432
Leu Thr Tyr Ala Thr Trp Lys Phe Ser Gly Phe Pro Lys Asp Arg Val           
    130                 135                 140                           

att ggc agt ggg acg tcg ctg gat agc tcg cgt ctg cga gtt gct ctg        480
Ile Gly Ser Gly Thr Ser Leu Asp Ser Ser Arg Leu Arg Val Ala Leu           
145                 150                 155                 160           

ggg aag caa ttc aac gtg gat ccg cgc tct gtg gat gcg tat atc atg        528
Gly Lys Gln Phe Asn Val Asp Pro Arg Ser Val Asp Ala Tyr Ile Met           
                165                 170                 175               

ggc gag cac ggc gat agt gag ttc gcc gca tat tcc acc gcc acg atc        576
Gly Glu His Gly Asp Ser Glu Phe Ala Ala Tyr Ser Thr Ala Thr Ile           
            180                 185                 190                   

ggc act cgg ccc gtg cgc gac gtt gcg aag gaa cag ggc gta tcc gac        624
Gly Thr Arg Pro Val Arg Asp Val Ala Lys Glu Gln Gly Val Ser Asp           
        195                 200                 205                       

gag gac ctg gcc aag ctg gaa gat ggc gtc cgc aac aag gcc tac gac        672
Glu Asp Leu Ala Lys Leu Glu Asp Gly Val Arg Asn Lys Ala Tyr Asp           
    210                 215                 220                           

atc atc aat ctc aag ggc gcg acc ttc tac ggt att ggt acc gcc ctg        720
Ile Ile Asn Leu Lys Gly Ala Thr Phe Tyr Gly Ile Gly Thr Ala Leu           
225                 230                 235                 240           

atg cgg atc tcc aag gcc atc ctg cgc gat gag aac gcc gtg ttg ccg        768
Met Arg Ile Ser Lys Ala Ile Leu Arg Asp Glu Asn Ala Val Leu Pro           
                245                 250                 255               

gtg ggg gct tac atg gat ggc cag tac ggc ctg aac gat atc tac atc        816
Val Gly Ala Tyr Met Asp Gly Gln Tyr Gly Leu Asn Asp Ile Tyr Ile           
            260                 265                 270                   

ggc aca ccg gcc gtc atc ggt ggc acc ggt ctg aag cag atc atc gag        864
Gly Thr Pro Ala Val Ile Gly Gly Thr Gly Leu Lys Gln Ile Ile Glu           
        275                 280                 285                       

agc ccg ctg tcc gcc gac gag ctg aaa aag atg cag gac agc gcc gca        912
Ser Pro Leu Ser Ala Asp Glu Leu Lys Lys Met Gln Asp Ser Ala Ala           
    290                 295                 300                           

acg ctc aaa aaa gtc ctc aat gat ggc ctg gcc gaa ctg gag aat aag        960
Thr Leu Lys Lys Val Leu Asn Asp Gly Leu Ala Glu Leu Glu Asn Lys           
305                 310                 315                 320           

taa                                                                    963


<210>  22
<211>  320
<212>  PRT
<213>  Artificial

<220>
<223>  Synthetic Construct

<400>  22

Met Ser Ser Met Pro Asn His Gln Lys Val Val Leu Val Gly Asp Gly 
1               5                   10                  15      


Ala Val Gly Ser Ser Tyr Ala Phe Ala Met Ala Gln Gln Gly Ile Ala 
            20                  25                  30          


Glu Glu Phe Val Ile Val Asp Val Val Lys Asp Arg Thr Lys Gly Asp 
        35                  40                  45              


Ala Leu Asp Leu Glu Asp Ala Gln Ala Phe Thr Ala Pro Lys Lys Ile 
    50                  55                  60                  


Tyr Ser Gly Glu Tyr Ser Asp Cys Lys Asp Ala Asp Leu Val Val Ile 
65                  70                  75                  80  


Thr Ala Gly Ala Pro Gln Lys Pro Gly Glu Ser Arg Leu Asp Leu Val 
                85                  90                  95      


Asn Lys Asn Leu Asn Ile Leu Ser Ser Ile Val Lys Pro Val Val Asp 
            100                 105                 110         


Ser Gly Phe Asp Gly Ile Phe Leu Val Ala Ala Asn Pro Val Asp Ile 
        115                 120                 125             


Leu Thr Tyr Ala Thr Trp Lys Phe Ser Gly Phe Pro Lys Asp Arg Val 
    130                 135                 140                 


Ile Gly Ser Gly Thr Ser Leu Asp Ser Ser Arg Leu Arg Val Ala Leu 
145                 150                 155                 160 


Gly Lys Gln Phe Asn Val Asp Pro Arg Ser Val Asp Ala Tyr Ile Met 
                165                 170                 175     


Gly Glu His Gly Asp Ser Glu Phe Ala Ala Tyr Ser Thr Ala Thr Ile 
            180                 185                 190         


Gly Thr Arg Pro Val Arg Asp Val Ala Lys Glu Gln Gly Val Ser Asp 
        195                 200                 205             


Glu Asp Leu Ala Lys Leu Glu Asp Gly Val Arg Asn Lys Ala Tyr Asp 
    210                 215                 220                 


Ile Ile Asn Leu Lys Gly Ala Thr Phe Tyr Gly Ile Gly Thr Ala Leu 
225                 230                 235                 240 


Met Arg Ile Ser Lys Ala Ile Leu Arg Asp Glu Asn Ala Val Leu Pro 
                245                 250                 255     


Val Gly Ala Tyr Met Asp Gly Gln Tyr Gly Leu Asn Asp Ile Tyr Ile 
            260                 265                 270         


Gly Thr Pro Ala Val Ile Gly Gly Thr Gly Leu Lys Gln Ile Ile Glu 
        275                 280                 285             


Ser Pro Leu Ser Ala Asp Glu Leu Lys Lys Met Gln Asp Ser Ala Ala 
    290                 295                 300                 


Thr Leu Lys Lys Val Leu Asn Asp Gly Leu Ala Glu Leu Glu Asn Lys 
305                 310                 315                 320 


<210>  23
<211>  954
<212>  DNA
<213>  Artificial

<220>
<223>  Synthetic construct (Staphylococcus aureus LDH)


<220>
<221>  CDS
<222>  (1)..(954)

<400>  23
atg aac aag ttc aag ggc aac aaa gtc gtg ttg atc ggg aat ggc gcc         48
Met Asn Lys Phe Lys Gly Asn Lys Val Val Leu Ile Gly Asn Gly Ala           
1               5                   10                  15                

gtc ggc tcg tcc tac gcg ttt tcg ctg gtc aac cag tcc atc gtg gac         96
Val Gly Ser Ser Tyr Ala Phe Ser Leu Val Asn Gln Ser Ile Val Asp           
            20                  25                  30                    

gaa ctc gtc ata atc gac ctc gac acc gaa aag gtt cgg ggt gac gtc        144
Glu Leu Val Ile Ile Asp Leu Asp Thr Glu Lys Val Arg Gly Asp Val           
        35                  40                  45                        

atg gac ctc aag cac gcc act ccg tat agc ccc acg acc gtg cgc gtg        192
Met Asp Leu Lys His Ala Thr Pro Tyr Ser Pro Thr Thr Val Arg Val           
    50                  55                  60                            

aag gcc gga gag tac agc gac tgc cat gac gcc aac ctg gtc gtc att        240
Lys Ala Gly Glu Tyr Ser Asp Cys His Asp Ala Asn Leu Val Val Ile           
65                  70                  75                  80            

tgc gcg ggt gcg gcg cag aaa ccg ggc gaa acc cgc ctc gat ctg gtg        288
Cys Ala Gly Ala Ala Gln Lys Pro Gly Glu Thr Arg Leu Asp Leu Val           
                85                  90                  95                

agc aag aac ctc aag atc ttc aag agt att gtg gga gaa gta atg gcc        336
Ser Lys Asn Leu Lys Ile Phe Lys Ser Ile Val Gly Glu Val Met Ala           
            100                 105                 110                   

tcg aag ttc gac ggc atc ttc ctg gtc gca acc aat cca gtg gat atc        384
Ser Lys Phe Asp Gly Ile Phe Leu Val Ala Thr Asn Pro Val Asp Ile           
        115                 120                 125                       

ctg gcc tac gca acc tgg aag ttc tcg gga ctg ccc aaa gag cga gtc        432
Leu Ala Tyr Ala Thr Trp Lys Phe Ser Gly Leu Pro Lys Glu Arg Val           
    130                 135                 140                           

atc ggc tcc ggc acc atc ctt gac tca gcg cgt ttc cgg ctg ctg ttg        480
Ile Gly Ser Gly Thr Ile Leu Asp Ser Ala Arg Phe Arg Leu Leu Leu           
145                 150                 155                 160           

agc gag gcc ttc gat gtg gcg ccc agg tct gtc gat gcc cag atc atc        528
Ser Glu Ala Phe Asp Val Ala Pro Arg Ser Val Asp Ala Gln Ile Ile           
                165                 170                 175               

ggc gag cac ggc gac acc gag ctt ccc gtg tgg tcc cat gcc aat atc        576
Gly Glu His Gly Asp Thr Glu Leu Pro Val Trp Ser His Ala Asn Ile           
            180                 185                 190                   

gct ggg cag ccg ctg aaa acg ctg ctg gag caa cgt cct gag ggc aag        624
Ala Gly Gln Pro Leu Lys Thr Leu Leu Glu Gln Arg Pro Glu Gly Lys           
        195                 200                 205                       

gcg cag atc gag cag atc ttt gtg cag acg cgc gac gcc gcc tac gac        672
Ala Gln Ile Glu Gln Ile Phe Val Gln Thr Arg Asp Ala Ala Tyr Asp           
    210                 215                 220                           

atc atc caa gcg aag ggc gct aca tac tat ggg gtg gcg atg ggg ctc        720
Ile Ile Gln Ala Lys Gly Ala Thr Tyr Tyr Gly Val Ala Met Gly Leu           
225                 230                 235                 240           

gcg cgc atc acg gaa gcc att ttc cgg aat gaa gat gca gtc ctg acc        768
Ala Arg Ile Thr Glu Ala Ile Phe Arg Asn Glu Asp Ala Val Leu Thr           
                245                 250                 255               

gta agc gcc ctg ctg gaa ggt gag tat gac gaa gaa gat gtc tac atc        816
Val Ser Ala Leu Leu Glu Gly Glu Tyr Asp Glu Glu Asp Val Tyr Ile           
            260                 265                 270                   

ggc gtt ccg gcc gtg atc aac cgc aac ggc atc cgg aac gtc gtg gag        864
Gly Val Pro Ala Val Ile Asn Arg Asn Gly Ile Arg Asn Val Val Glu           
        275                 280                 285                       

atc ccg ctg aac gat gaa gaa cag agc aag ttc gcc cac tcc gcg aaa        912
Ile Pro Leu Asn Asp Glu Glu Gln Ser Lys Phe Ala His Ser Ala Lys           
    290                 295                 300                           

acc ctg aaa gac atc atg gcc gag gcc gag gaa ttg aag taa                954
Thr Leu Lys Asp Ile Met Ala Glu Ala Glu Glu Leu Lys                       
305                 310                 315                               


<210>  24
<211>  317
<212>  PRT
<213>  Artificial

<220>
<223>  Synthetic Construct

<400>  24

Met Asn Lys Phe Lys Gly Asn Lys Val Val Leu Ile Gly Asn Gly Ala 
1               5                   10                  15      


Val Gly Ser Ser Tyr Ala Phe Ser Leu Val Asn Gln Ser Ile Val Asp 
            20                  25                  30          


Glu Leu Val Ile Ile Asp Leu Asp Thr Glu Lys Val Arg Gly Asp Val 
        35                  40                  45              


Met Asp Leu Lys His Ala Thr Pro Tyr Ser Pro Thr Thr Val Arg Val 
    50                  55                  60                  


Lys Ala Gly Glu Tyr Ser Asp Cys His Asp Ala Asn Leu Val Val Ile 
65                  70                  75                  80  


Cys Ala Gly Ala Ala Gln Lys Pro Gly Glu Thr Arg Leu Asp Leu Val 
                85                  90                  95      


Ser Lys Asn Leu Lys Ile Phe Lys Ser Ile Val Gly Glu Val Met Ala 
            100                 105                 110         


Ser Lys Phe Asp Gly Ile Phe Leu Val Ala Thr Asn Pro Val Asp Ile 
        115                 120                 125             


Leu Ala Tyr Ala Thr Trp Lys Phe Ser Gly Leu Pro Lys Glu Arg Val 
    130                 135                 140                 


Ile Gly Ser Gly Thr Ile Leu Asp Ser Ala Arg Phe Arg Leu Leu Leu 
145                 150                 155                 160 


Ser Glu Ala Phe Asp Val Ala Pro Arg Ser Val Asp Ala Gln Ile Ile 
                165                 170                 175     


Gly Glu His Gly Asp Thr Glu Leu Pro Val Trp Ser His Ala Asn Ile 
            180                 185                 190         


Ala Gly Gln Pro Leu Lys Thr Leu Leu Glu Gln Arg Pro Glu Gly Lys 
        195                 200                 205             


Ala Gln Ile Glu Gln Ile Phe Val Gln Thr Arg Asp Ala Ala Tyr Asp 
    210                 215                 220                 


Ile Ile Gln Ala Lys Gly Ala Thr Tyr Tyr Gly Val Ala Met Gly Leu 
225                 230                 235                 240 


Ala Arg Ile Thr Glu Ala Ile Phe Arg Asn Glu Asp Ala Val Leu Thr 
                245                 250                 255     


Val Ser Ala Leu Leu Glu Gly Glu Tyr Asp Glu Glu Asp Val Tyr Ile 
            260                 265                 270         


Gly Val Pro Ala Val Ile Asn Arg Asn Gly Ile Arg Asn Val Val Glu 
        275                 280                 285             


Ile Pro Leu Asn Asp Glu Glu Gln Ser Lys Phe Ala His Ser Ala Lys 
    290                 295                 300                 


Thr Leu Lys Asp Ile Met Ala Glu Ala Glu Glu Leu Lys 
305                 310                 315         


<210>  25
<211>  954
<212>  DNA
<213>  Artificial

<220>
<223>  Synthetic construct (Bacillus caldolyticus LDH)


<220>
<221>  CDS
<222>  (1)..(954)

<400>  25
atg aaa aac aat ggg ggc acc cgc gtg gtc gtc atc gga acc ggc ttc         48
Met Lys Asn Asn Gly Gly Thr Arg Val Val Val Ile Gly Thr Gly Phe           
1               5                   10                  15                

gtc ggc gcc tcg tac gcg ttc gcc ctg atg aac cag ggt att gcc gac         96
Val Gly Ala Ser Tyr Ala Phe Ala Leu Met Asn Gln Gly Ile Ala Asp           
            20                  25                  30                    

gag atc gtg ctg atc gac gcg aac gag tcc aag gcc atc ggc gat gca        144
Glu Ile Val Leu Ile Asp Ala Asn Glu Ser Lys Ala Ile Gly Asp Ala           
        35                  40                  45                        

atg gac ttt aac cac ggc aag gtt ttc gcc ccc aaa ccg gcg gac atc        192
Met Asp Phe Asn His Gly Lys Val Phe Ala Pro Lys Pro Ala Asp Ile           
    50                  55                  60                            

tgg cat ggc gat tat gac gac tgc cgg gac gcc gac ctg gtg gtg atc        240
Trp His Gly Asp Tyr Asp Asp Cys Arg Asp Ala Asp Leu Val Val Ile           
65                  70                  75                  80            

tgc gcg ggt gcg aac cag aag ccg gga gaa acc cgc ctt gac ctg gtt        288
Cys Ala Gly Ala Asn Gln Lys Pro Gly Glu Thr Arg Leu Asp Leu Val           
                85                  90                  95                

gac aag aac atc gcc atc ttc cgc tcg atc gtc gaa agc gtc atg gcc        336
Asp Lys Asn Ile Ala Ile Phe Arg Ser Ile Val Glu Ser Val Met Ala           
            100                 105                 110                   

agc ggg ttc caa ggc ctc ttc ctg gtc gcc acc aac ccc gtc gac att        384
Ser Gly Phe Gln Gly Leu Phe Leu Val Ala Thr Asn Pro Val Asp Ile           
        115                 120                 125                       

ctc acg tac gcg acc tgg aaa ttc tcg ggc ctg ccg cac gag cgg gtg        432
Leu Thr Tyr Ala Thr Trp Lys Phe Ser Gly Leu Pro His Glu Arg Val           
    130                 135                 140                           

atc ggc agc ggc acg atc ctg gat act gcc cgg ttt cga ttc ttg ctg        480
Ile Gly Ser Gly Thr Ile Leu Asp Thr Ala Arg Phe Arg Phe Leu Leu           
145                 150                 155                 160           

ggt gag tac ttc agc gtc gcc cca cag aat gtg cat gcg tac atc att        528
Gly Glu Tyr Phe Ser Val Ala Pro Gln Asn Val His Ala Tyr Ile Ile           
                165                 170                 175               

ggc gaa cat ggc gat acg gaa ctc ccc gtc tgg tcc cag gct gat atc        576
Gly Glu His Gly Asp Thr Glu Leu Pro Val Trp Ser Gln Ala Asp Ile           
            180                 185                 190                   

ggg gga gtc ccg atc cgg aag ctc gtg gaa tcc aag ggc gaa gaa gcg        624
Gly Gly Val Pro Ile Arg Lys Leu Val Glu Ser Lys Gly Glu Glu Ala           
        195                 200                 205                       

cag aaa gaa ttg gag cgt atc ttc gtg aat gta cgt gat gcc gcc tat        672
Gln Lys Glu Leu Glu Arg Ile Phe Val Asn Val Arg Asp Ala Ala Tyr           
    210                 215                 220                           

cag ata atc gaa aag aaa ggc gcc acc tac tat ggt atc gcg atg ggg        720
Gln Ile Ile Glu Lys Lys Gly Ala Thr Tyr Tyr Gly Ile Ala Met Gly           
225                 230                 235                 240           

ctg gcc agg gtg acc cgc gca atc ctg cac aac gag aat gcg atc ctg        768
Leu Ala Arg Val Thr Arg Ala Ile Leu His Asn Glu Asn Ala Ile Leu           
                245                 250                 255               

aca gtg tcc gcg tac ctg gat ggg cct tac ggc gag cgc gac gtg tat        816
Thr Val Ser Ala Tyr Leu Asp Gly Pro Tyr Gly Glu Arg Asp Val Tyr           
            260                 265                 270                   

atc ggc gtg ccg gca gtc atc aac cgg aac ggc atc cgc gaa gtc atc        864
Ile Gly Val Pro Ala Val Ile Asn Arg Asn Gly Ile Arg Glu Val Ile           
        275                 280                 285                       

gag atc gag ctg aac gac gac gag aag aac cgc ttc cac cac tcg gcc        912
Glu Ile Glu Leu Asn Asp Asp Glu Lys Asn Arg Phe His His Ser Ala           
    290                 295                 300                           

gct acc ctc aag agt gtg ttg gcc cgg ttc ttc acg cgc taa                954
Ala Thr Leu Lys Ser Val Leu Ala Arg Phe Phe Thr Arg                       
305                 310                 315                               


<210>  26
<211>  317
<212>  PRT
<213>  Artificial

<220>
<223>  Synthetic Construct

<400>  26

Met Lys Asn Asn Gly Gly Thr Arg Val Val Val Ile Gly Thr Gly Phe 
1               5                   10                  15      


Val Gly Ala Ser Tyr Ala Phe Ala Leu Met Asn Gln Gly Ile Ala Asp 
            20                  25                  30          


Glu Ile Val Leu Ile Asp Ala Asn Glu Ser Lys Ala Ile Gly Asp Ala 
        35                  40                  45              


Met Asp Phe Asn His Gly Lys Val Phe Ala Pro Lys Pro Ala Asp Ile 
    50                  55                  60                  


Trp His Gly Asp Tyr Asp Asp Cys Arg Asp Ala Asp Leu Val Val Ile 
65                  70                  75                  80  


Cys Ala Gly Ala Asn Gln Lys Pro Gly Glu Thr Arg Leu Asp Leu Val 
                85                  90                  95      


Asp Lys Asn Ile Ala Ile Phe Arg Ser Ile Val Glu Ser Val Met Ala 
            100                 105                 110         


Ser Gly Phe Gln Gly Leu Phe Leu Val Ala Thr Asn Pro Val Asp Ile 
        115                 120                 125             


Leu Thr Tyr Ala Thr Trp Lys Phe Ser Gly Leu Pro His Glu Arg Val 
    130                 135                 140                 


Ile Gly Ser Gly Thr Ile Leu Asp Thr Ala Arg Phe Arg Phe Leu Leu 
145                 150                 155                 160 


Gly Glu Tyr Phe Ser Val Ala Pro Gln Asn Val His Ala Tyr Ile Ile 
                165                 170                 175     


Gly Glu His Gly Asp Thr Glu Leu Pro Val Trp Ser Gln Ala Asp Ile 
            180                 185                 190         


Gly Gly Val Pro Ile Arg Lys Leu Val Glu Ser Lys Gly Glu Glu Ala 
        195                 200                 205             


Gln Lys Glu Leu Glu Arg Ile Phe Val Asn Val Arg Asp Ala Ala Tyr 
    210                 215                 220                 


Gln Ile Ile Glu Lys Lys Gly Ala Thr Tyr Tyr Gly Ile Ala Met Gly 
225                 230                 235                 240 


Leu Ala Arg Val Thr Arg Ala Ile Leu His Asn Glu Asn Ala Ile Leu 
                245                 250                 255     


Thr Val Ser Ala Tyr Leu Asp Gly Pro Tyr Gly Glu Arg Asp Val Tyr 
            260                 265                 270         


Ile Gly Val Pro Ala Val Ile Asn Arg Asn Gly Ile Arg Glu Val Ile 
        275                 280                 285             


Glu Ile Glu Leu Asn Asp Asp Glu Lys Asn Arg Phe His His Ser Ala 
    290                 295                 300                 


Ala Thr Leu Lys Ser Val Leu Ala Arg Phe Phe Thr Arg 
305                 310                 315         


<210>  27
<211>  1002
<212>  DNA
<213>  Artificial

<220>
<223>  Synthetic construct (Actinomyces visosus LDH)


<220>
<221>  CDS
<222>  (1)..(1002)

<400>  27
atg tcc gac cat atc acg aca acc gcc gag ggc tcc tac ccg acc aat         48
Met Ser Asp His Ile Thr Thr Thr Ala Glu Gly Ser Tyr Pro Thr Asn           
1               5                   10                  15                

cgg tcc gga cgg ccc agc aaa gtg gcc gtg atc ggc gcg ggc gcg gtc         96
Arg Ser Gly Arg Pro Ser Lys Val Ala Val Ile Gly Ala Gly Ala Val           
            20                  25                  30                    

ggg agc acc ctg gcc tac gcc tgt gtc acc aaa ggc gtc gct cgc gag        144
Gly Ser Thr Leu Ala Tyr Ala Cys Val Thr Lys Gly Val Ala Arg Glu           
        35                  40                  45                        

gtc gtc ttg cag gac ata gtc aag gaa aaa gta gaa gcc gaa gcg ctg        192
Val Val Leu Gln Asp Ile Val Lys Glu Lys Val Glu Ala Glu Ala Leu           
    50                  55                  60                            

gac atc gcc cag ggt atc cag ttc acc tcc gcg gga agt gtg tct ggc        240
Asp Ile Ala Gln Gly Ile Gln Phe Thr Ser Ala Gly Ser Val Ser Gly           
65                  70                  75                  80            

tcg gat gac ccg gag atc tgc cgc gat gcc gac gtg att gcc atc act        288
Ser Asp Asp Pro Glu Ile Cys Arg Asp Ala Asp Val Ile Ala Ile Thr           
                85                  90                  95                

gca ggc gca aag cag aag ccc ggc cag tcg cgc ttg gag ctg gcg gga        336
Ala Gly Ala Lys Gln Lys Pro Gly Gln Ser Arg Leu Glu Leu Ala Gly           
            100                 105                 110                   

gcg acc gtg ggg atc atg gaa aag atc ctg ccc aag ctc gtg gaa gtt        384
Ala Thr Val Gly Ile Met Glu Lys Ile Leu Pro Lys Leu Val Glu Val           
        115                 120                 125                       

gcc ccc aac gcc atc ttc gtc ctg gtc gcc aac ccg gtc gat gtg gtg        432
Ala Pro Asn Ala Ile Phe Val Leu Val Ala Asn Pro Val Asp Val Val           
    130                 135                 140                           

acg tac tgc gcc aag aaa atc acc ggc ctg ccg gag aac caa gtg ttt        480
Thr Tyr Cys Ala Lys Lys Ile Thr Gly Leu Pro Glu Asn Gln Val Phe           
145                 150                 155                 160           

ggc tcg ggc act gtc ctc gac acg gcc cgt atg cgc tat ctg atc agc        528
Gly Ser Gly Thr Val Leu Asp Thr Ala Arg Met Arg Tyr Leu Ile Ser           
                165                 170                 175               

ctc gaa acg ggg acc gct gtc cag aac atc cac ggc tat atc gcg ggt        576
Leu Glu Thr Gly Thr Ala Val Gln Asn Ile His Gly Tyr Ile Ala Gly           
            180                 185                 190                   

gag cat ggc gat tcg gaa gtc cca ctg tgg tcc tcg acc gaa atc ggc        624
Glu His Gly Asp Ser Glu Val Pro Leu Trp Ser Ser Thr Glu Ile Gly           
        195                 200                 205                       

ggt gtg ccg att acg cag tgg ggc acc acg ttg gac ggt ggc gtg ttc        672
Gly Val Pro Ile Thr Gln Trp Gly Thr Thr Leu Asp Gly Gly Val Phe           
    210                 215                 220                           

gac gag agc aag cgc gag cgg atc gcg cat gac gtc gtg cgc agc gcc        720
Asp Glu Ser Lys Arg Glu Arg Ile Ala His Asp Val Val Arg Ser Ala           
225                 230                 235                 240           

tat cgg atc atc gag ggg aag ggc gcg acc aac tac gcg gtt ggc ctg        768
Tyr Arg Ile Ile Glu Gly Lys Gly Ala Thr Asn Tyr Ala Val Gly Leu           
                245                 250                 255               

gcc gtg cag cgt atc atc ggc gca gtg ctg aat gac gag caa agg gtc        816
Ala Val Gln Arg Ile Ile Gly Ala Val Leu Asn Asp Glu Gln Arg Val           
            260                 265                 270                   

ctc acg atc agc ccg ctg ctc gat aac tgg cac ggc att tca gat gtg        864
Leu Thr Ile Ser Pro Leu Leu Asp Asn Trp His Gly Ile Ser Asp Val           
        275                 280                 285                       

tgc atg gcc gtc cct acc att gtt ggc cgc gag ggt gcg gga cgc cgg        912
Cys Met Ala Val Pro Thr Ile Val Gly Arg Glu Gly Ala Gly Arg Arg           
    290                 295                 300                           

ctg gag ctc ccg ctg acc ccc gaa gaa aag gaa cga ctg acc gct tcc        960
Leu Glu Leu Pro Leu Thr Pro Glu Glu Lys Glu Arg Leu Thr Ala Ser           
305                 310                 315                 320           

gcc gac cac ctt cgg gaa gta gcc aga ggg ctg ggg tac taa               1002
Ala Asp His Leu Arg Glu Val Ala Arg Gly Leu Gly Tyr                       
                325                 330                                   


<210>  28
<211>  333
<212>  PRT
<213>  Artificial

<220>
<223>  Synthetic Construct

<400>  28

Met Ser Asp His Ile Thr Thr Thr Ala Glu Gly Ser Tyr Pro Thr Asn 
1               5                   10                  15      


Arg Ser Gly Arg Pro Ser Lys Val Ala Val Ile Gly Ala Gly Ala Val 
            20                  25                  30          


Gly Ser Thr Leu Ala Tyr Ala Cys Val Thr Lys Gly Val Ala Arg Glu 
        35                  40                  45              


Val Val Leu Gln Asp Ile Val Lys Glu Lys Val Glu Ala Glu Ala Leu 
    50                  55                  60                  


Asp Ile Ala Gln Gly Ile Gln Phe Thr Ser Ala Gly Ser Val Ser Gly 
65                  70                  75                  80  


Ser Asp Asp Pro Glu Ile Cys Arg Asp Ala Asp Val Ile Ala Ile Thr 
                85                  90                  95      


Ala Gly Ala Lys Gln Lys Pro Gly Gln Ser Arg Leu Glu Leu Ala Gly 
            100                 105                 110         


Ala Thr Val Gly Ile Met Glu Lys Ile Leu Pro Lys Leu Val Glu Val 
        115                 120                 125             


Ala Pro Asn Ala Ile Phe Val Leu Val Ala Asn Pro Val Asp Val Val 
    130                 135                 140                 


Thr Tyr Cys Ala Lys Lys Ile Thr Gly Leu Pro Glu Asn Gln Val Phe 
145                 150                 155                 160 


Gly Ser Gly Thr Val Leu Asp Thr Ala Arg Met Arg Tyr Leu Ile Ser 
                165                 170                 175     


Leu Glu Thr Gly Thr Ala Val Gln Asn Ile His Gly Tyr Ile Ala Gly 
            180                 185                 190         


Glu His Gly Asp Ser Glu Val Pro Leu Trp Ser Ser Thr Glu Ile Gly 
        195                 200                 205             


Gly Val Pro Ile Thr Gln Trp Gly Thr Thr Leu Asp Gly Gly Val Phe 
    210                 215                 220                 


Asp Glu Ser Lys Arg Glu Arg Ile Ala His Asp Val Val Arg Ser Ala 
225                 230                 235                 240 


Tyr Arg Ile Ile Glu Gly Lys Gly Ala Thr Asn Tyr Ala Val Gly Leu 
                245                 250                 255     


Ala Val Gln Arg Ile Ile Gly Ala Val Leu Asn Asp Glu Gln Arg Val 
            260                 265                 270         


Leu Thr Ile Ser Pro Leu Leu Asp Asn Trp His Gly Ile Ser Asp Val 
        275                 280                 285             


Cys Met Ala Val Pro Thr Ile Val Gly Arg Glu Gly Ala Gly Arg Arg 
    290                 295                 300                 


Leu Glu Leu Pro Leu Thr Pro Glu Glu Lys Glu Arg Leu Thr Ala Ser 
305                 310                 315                 320 


Ala Asp His Leu Arg Glu Val Ala Arg Gly Leu Gly Tyr 
                325                 330             


<210>  29
<211>  945
<212>  DNA
<213>  Artificial

<220>
<223>  Synthetic construct (Bacillus anthracis LDH)


<220>
<221>  CDS
<222>  (1)..(945)

<400>  29
atg aaa aag ggc atc aac cga gtg gtc ctg gtc ggt acc gga gcc gtg         48
Met Lys Lys Gly Ile Asn Arg Val Val Leu Val Gly Thr Gly Ala Val           
1               5                   10                  15                

ggg tgc tcc tat gct tac tca atg atc aac cag ggc gtg gcc gag gaa         96
Gly Cys Ser Tyr Ala Tyr Ser Met Ile Asn Gln Gly Val Ala Glu Glu           
            20                  25                  30                    

ttc gtg ctg gtc gac gtc aac gaa gcc aag gcc gag ggt gag gca atg        144
Phe Val Leu Val Asp Val Asn Glu Ala Lys Ala Glu Gly Glu Ala Met           
        35                  40                  45                        

gac ctg tcc cac gcg gtc ccg ttc tcg ccc agc ccc acc aag gtg tgg        192
Asp Leu Ser His Ala Val Pro Phe Ser Pro Ser Pro Thr Lys Val Trp           
    50                  55                  60                            

agc ggc agc tac gcg gac tgc aaa gac gcc gat ctg gtg gtc atc acc        240
Ser Gly Ser Tyr Ala Asp Cys Lys Asp Ala Asp Leu Val Val Ile Thr           
65                  70                  75                  80            

gcc gga ctc cct cag aag ccg ggt gaa acc cgc ttg gac ctg gtc gag        288
Ala Gly Leu Pro Gln Lys Pro Gly Glu Thr Arg Leu Asp Leu Val Glu           
                85                  90                  95                

aag aac acg aag atc ttc aaa cag atc gtg agg gga atc atg gat tcc        336
Lys Asn Thr Lys Ile Phe Lys Gln Ile Val Arg Gly Ile Met Asp Ser           
            100                 105                 110                   

ggc ttt gac ggc atc ttc ctc atc gcg acg aac ccc gtg gat atc ttg        384
Gly Phe Asp Gly Ile Phe Leu Ile Ala Thr Asn Pro Val Asp Ile Leu           
        115                 120                 125                       

acc tat gtc acc tgg aag gaa tcc ggc ctc ccg aaa gag cgc gtc att        432
Thr Tyr Val Thr Trp Lys Glu Ser Gly Leu Pro Lys Glu Arg Val Ile           
    130                 135                 140                           

ggc agt ggg acc acg ctg gac agc gct cgc ttc cgg tat atg ctg ggc        480
Gly Ser Gly Thr Thr Leu Asp Ser Ala Arg Phe Arg Tyr Met Leu Gly           
145                 150                 155                 160           

gac tac ctg gac gtg gac ccg cgg aac gtc cat gcc tac atc gta ggt        528
Asp Tyr Leu Asp Val Asp Pro Arg Asn Val His Ala Tyr Ile Val Gly           
                165                 170                 175               

gaa cat ggc gat acc gag ctg ccc gtt tgg tcg cac gcg acg atc ggc        576
Glu His Gly Asp Thr Glu Leu Pro Val Trp Ser His Ala Thr Ile Gly           
            180                 185                 190                   

gtg cag aag ctg gaa aca atc ctc gcc aac aat gaa cag tac aag caa        624
Val Gln Lys Leu Glu Thr Ile Leu Ala Asn Asn Glu Gln Tyr Lys Gln           
        195                 200                 205                       

gag gat ctc gat aag att ttc gaa aac gtc cgg gac gcg gcc tac cat        672
Glu Asp Leu Asp Lys Ile Phe Glu Asn Val Arg Asp Ala Ala Tyr His           
    210                 215                 220                           

atc atc gag cgc aaa ggg gcc acc tat tac ggc atc ggg atg tcg ctc        720
Ile Ile Glu Arg Lys Gly Ala Thr Tyr Tyr Gly Ile Gly Met Ser Leu           
225                 230                 235                 240           

ctg cgg gtg acc aag gca ata ctg aat aat gag aat agc gtg ctg act        768
Leu Arg Val Thr Lys Ala Ile Leu Asn Asn Glu Asn Ser Val Leu Thr           
                245                 250                 255               

gtc tct gcg tac ctt gag ggc cag tat ggc gag aaa gac gcg tac gtg        816
Val Ser Ala Tyr Leu Glu Gly Gln Tyr Gly Glu Lys Asp Ala Tyr Val           
            260                 265                 270                   

ggc gta ccg gcc gtt atc aac cgc gag ggc gtc cgt gaa atc gtc gaa        864
Gly Val Pro Ala Val Ile Asn Arg Glu Gly Val Arg Glu Ile Val Glu           
        275                 280                 285                       

ctg gag ttg aac gaa gag gaa aag gcc aag ttc gcc cac tcg gtg aag        912
Leu Glu Leu Asn Glu Glu Glu Lys Ala Lys Phe Ala His Ser Val Lys           
    290                 295                 300                           

gtc ctc aag gaa acg atg gcg cca gtg ctg taa                            945
Val Leu Lys Glu Thr Met Ala Pro Val Leu                                   
305                 310                                                   


<210>  30
<211>  314
<212>  PRT
<213>  Artificial

<220>
<223>  Synthetic Construct

<400>  30

Met Lys Lys Gly Ile Asn Arg Val Val Leu Val Gly Thr Gly Ala Val 
1               5                   10                  15      


Gly Cys Ser Tyr Ala Tyr Ser Met Ile Asn Gln Gly Val Ala Glu Glu 
            20                  25                  30          


Phe Val Leu Val Asp Val Asn Glu Ala Lys Ala Glu Gly Glu Ala Met 
        35                  40                  45              


Asp Leu Ser His Ala Val Pro Phe Ser Pro Ser Pro Thr Lys Val Trp 
    50                  55                  60                  


Ser Gly Ser Tyr Ala Asp Cys Lys Asp Ala Asp Leu Val Val Ile Thr 
65                  70                  75                  80  


Ala Gly Leu Pro Gln Lys Pro Gly Glu Thr Arg Leu Asp Leu Val Glu 
                85                  90                  95      


Lys Asn Thr Lys Ile Phe Lys Gln Ile Val Arg Gly Ile Met Asp Ser 
            100                 105                 110         


Gly Phe Asp Gly Ile Phe Leu Ile Ala Thr Asn Pro Val Asp Ile Leu 
        115                 120                 125             


Thr Tyr Val Thr Trp Lys Glu Ser Gly Leu Pro Lys Glu Arg Val Ile 
    130                 135                 140                 


Gly Ser Gly Thr Thr Leu Asp Ser Ala Arg Phe Arg Tyr Met Leu Gly 
145                 150                 155                 160 


Asp Tyr Leu Asp Val Asp Pro Arg Asn Val His Ala Tyr Ile Val Gly 
                165                 170                 175     


Glu His Gly Asp Thr Glu Leu Pro Val Trp Ser His Ala Thr Ile Gly 
            180                 185                 190         


Val Gln Lys Leu Glu Thr Ile Leu Ala Asn Asn Glu Gln Tyr Lys Gln 
        195                 200                 205             


Glu Asp Leu Asp Lys Ile Phe Glu Asn Val Arg Asp Ala Ala Tyr His 
    210                 215                 220                 


Ile Ile Glu Arg Lys Gly Ala Thr Tyr Tyr Gly Ile Gly Met Ser Leu 
225                 230                 235                 240 


Leu Arg Val Thr Lys Ala Ile Leu Asn Asn Glu Asn Ser Val Leu Thr 
                245                 250                 255     


Val Ser Ala Tyr Leu Glu Gly Gln Tyr Gly Glu Lys Asp Ala Tyr Val 
            260                 265                 270         


Gly Val Pro Ala Val Ile Asn Arg Glu Gly Val Arg Glu Ile Val Glu 
        275                 280                 285             


Leu Glu Leu Asn Glu Glu Glu Lys Ala Lys Phe Ala His Ser Val Lys 
    290                 295                 300                 


Val Leu Lys Glu Thr Met Ala Pro Val Leu 
305                 310                 


<210>  31
<211>  957
<212>  DNA
<213>  Artificial

<220>
<223>  Synthetic construct (Ruminococcus torques LDH)


<220>
<221>  CDS
<222>  (1)..(957)

<400>  31
atg aag aaa aaa gtg atc aac tcg aag aaa gcc gtg atg atc ggg tgc         48
Met Lys Lys Lys Val Ile Asn Ser Lys Lys Ala Val Met Ile Gly Cys           
1               5                   10                  15                

ggc ttt gtg ggt agc gcg tcg gtg ttc gca ctg atg cag agt ggc ctg         96
Gly Phe Val Gly Ser Ala Ser Val Phe Ala Leu Met Gln Ser Gly Leu           
            20                  25                  30                    

ttc acc gag atc gtc ctc atc gac gct gac aag aat aag gcc gaa ggc        144
Phe Thr Glu Ile Val Leu Ile Asp Ala Asp Lys Asn Lys Ala Glu Gly           
        35                  40                  45                        

gag gcc atg gat atc tcg cac ggt att ccg ttc gcg tcc cct atg aag        192
Glu Ala Met Asp Ile Ser His Gly Ile Pro Phe Ala Ser Pro Met Lys           
    50                  55                  60                            

atc tat gcg ggc gac tac gat gat gtc gcc gat gcg gca atc gtt gtg        240
Ile Tyr Ala Gly Asp Tyr Asp Asp Val Ala Asp Ala Ala Ile Val Val           
65                  70                  75                  80            

atc tcc gcc gga gcc ggc cag aaa ccc ggc gag act cgg ctg gac ctg        288
Ile Ser Ala Gly Ala Gly Gln Lys Pro Gly Glu Thr Arg Leu Asp Leu           
                85                  90                  95                

gtc aac aaa aac gtc gcg atc ttc aag tcg atc att ccg gag att gcg        336
Val Asn Lys Asn Val Ala Ile Phe Lys Ser Ile Ile Pro Glu Ile Ala           
            100                 105                 110                   

aag cgc aac ttc gcc ggt atc atg ctg gtc gtc gcc aac ccg gtc gat        384
Lys Arg Asn Phe Ala Gly Ile Met Leu Val Val Ala Asn Pro Val Asp           
        115                 120                 125                       

atc ctg acc caa gtg gcc atc aag ttg tcc ggg ctg ccc gag aac cgc        432
Ile Leu Thr Gln Val Ala Ile Lys Leu Ser Gly Leu Pro Glu Asn Arg           
    130                 135                 140                           

gtc atc ggc tcg ggc acg gtg ctc gac agt gcg cgg ctg agg tac aag        480
Val Ile Gly Ser Gly Thr Val Leu Asp Ser Ala Arg Leu Arg Tyr Lys           
145                 150                 155                 160           

ttg ggg gaa cat ctc tcc gtc gac tcc cgg agc gtg cat gcc ttc atc        528
Leu Gly Glu His Leu Ser Val Asp Ser Arg Ser Val His Ala Phe Ile           
                165                 170                 175               

gtc ggc gaa cac ggg gac tcc gaa gtc gtg gct tgg agc agc gcg aat        576
Val Gly Glu His Gly Asp Ser Glu Val Val Ala Trp Ser Ser Ala Asn           
            180                 185                 190                   

gtg tcg gga gtg ccg ctg agc gaa atg tgc gag atg cgt ggc cac tac        624
Val Ser Gly Val Pro Leu Ser Glu Met Cys Glu Met Arg Gly His Tyr           
        195                 200                 205                       

aag cat aag gaa aac acg gcc gaa atc gcc acc gcg gta aag aat tct        672
Lys His Lys Glu Asn Thr Ala Glu Ile Ala Thr Ala Val Lys Asn Ser           
    210                 215                 220                           

gcg tac gag ata atc aac aag aag cac gcc acc tac tat ggc atc gca        720
Ala Tyr Glu Ile Ile Asn Lys Lys His Ala Thr Tyr Tyr Gly Ile Ala           
225                 230                 235                 240           

atg agc gtt aaa cgc atc tgt gag gtc atc atg cgc gat gag aag tcg        768
Met Ser Val Lys Arg Ile Cys Glu Val Ile Met Arg Asp Glu Lys Ser           
                245                 250                 255               

atc ctt ccc gta tcc cac atg att cat ggc gtc tat gac atc gac ggc        816
Ile Leu Pro Val Ser His Met Ile His Gly Val Tyr Asp Ile Asp Gly           
            260                 265                 270                   

gtg agc ctc tca atg cca gcc atc gtg ggt gcc gac ggc atc gag agc        864
Val Ser Leu Ser Met Pro Ala Ile Val Gly Ala Asp Gly Ile Glu Ser           
        275                 280                 285                       

gac atc ccg ata aac ctc agc gga gaa gaa gcg ctg aag ctg aaa gag        912
Asp Ile Pro Ile Asn Leu Ser Gly Glu Glu Ala Leu Lys Leu Lys Glu           
    290                 295                 300                           

tcc gcc gac tcg ctg aag aaa atc atc gaa acc atc gaa ctg taa            957
Ser Ala Asp Ser Leu Lys Lys Ile Ile Glu Thr Ile Glu Leu                   
305                 310                 315                               


<210>  32
<211>  318
<212>  PRT
<213>  Artificial

<220>
<223>  Synthetic Construct

<400>  32

Met Lys Lys Lys Val Ile Asn Ser Lys Lys Ala Val Met Ile Gly Cys 
1               5                   10                  15      


Gly Phe Val Gly Ser Ala Ser Val Phe Ala Leu Met Gln Ser Gly Leu 
            20                  25                  30          


Phe Thr Glu Ile Val Leu Ile Asp Ala Asp Lys Asn Lys Ala Glu Gly 
        35                  40                  45              


Glu Ala Met Asp Ile Ser His Gly Ile Pro Phe Ala Ser Pro Met Lys 
    50                  55                  60                  


Ile Tyr Ala Gly Asp Tyr Asp Asp Val Ala Asp Ala Ala Ile Val Val 
65                  70                  75                  80  


Ile Ser Ala Gly Ala Gly Gln Lys Pro Gly Glu Thr Arg Leu Asp Leu 
                85                  90                  95      


Val Asn Lys Asn Val Ala Ile Phe Lys Ser Ile Ile Pro Glu Ile Ala 
            100                 105                 110         


Lys Arg Asn Phe Ala Gly Ile Met Leu Val Val Ala Asn Pro Val Asp 
        115                 120                 125             


Ile Leu Thr Gln Val Ala Ile Lys Leu Ser Gly Leu Pro Glu Asn Arg 
    130                 135                 140                 


Val Ile Gly Ser Gly Thr Val Leu Asp Ser Ala Arg Leu Arg Tyr Lys 
145                 150                 155                 160 


Leu Gly Glu His Leu Ser Val Asp Ser Arg Ser Val His Ala Phe Ile 
                165                 170                 175     


Val Gly Glu His Gly Asp Ser Glu Val Val Ala Trp Ser Ser Ala Asn 
            180                 185                 190         


Val Ser Gly Val Pro Leu Ser Glu Met Cys Glu Met Arg Gly His Tyr 
        195                 200                 205             


Lys His Lys Glu Asn Thr Ala Glu Ile Ala Thr Ala Val Lys Asn Ser 
    210                 215                 220                 


Ala Tyr Glu Ile Ile Asn Lys Lys His Ala Thr Tyr Tyr Gly Ile Ala 
225                 230                 235                 240 


Met Ser Val Lys Arg Ile Cys Glu Val Ile Met Arg Asp Glu Lys Ser 
                245                 250                 255     


Ile Leu Pro Val Ser His Met Ile His Gly Val Tyr Asp Ile Asp Gly 
            260                 265                 270         


Val Ser Leu Ser Met Pro Ala Ile Val Gly Ala Asp Gly Ile Glu Ser 
        275                 280                 285             


Asp Ile Pro Ile Asn Leu Ser Gly Glu Glu Ala Leu Lys Leu Lys Glu 
    290                 295                 300                 


Ser Ala Asp Ser Leu Lys Lys Ile Ile Glu Thr Ile Glu Leu 
305                 310                 315             


<210>  33
<211>  942
<212>  DNA
<213>  Artificial

<220>
<223>  Synthetic construct (Listeria marthii LDH)


<220>
<221>  CDS
<222>  (1)..(942)

<400>  33
atg aag gat cat cag aag atc atc ctg gta ggc gat ggt gcc gtg gga         48
Met Lys Asp His Gln Lys Ile Ile Leu Val Gly Asp Gly Ala Val Gly           
1               5                   10                  15                

tcc tcc tac gcc ttc gcc tgc gtc aac ctt tcg att ggc cag gaa ttc         96
Ser Ser Tyr Ala Phe Ala Cys Val Asn Leu Ser Ile Gly Gln Glu Phe           
            20                  25                  30                    

ggc att atc gac atc gac aag gat agg aca atc ggt gac gcg atg gac        144
Gly Ile Ile Asp Ile Asp Lys Asp Arg Thr Ile Gly Asp Ala Met Asp           
        35                  40                  45                        

ctc tcc cat gcc gtg ccc ttc tct acc ccg aaa aag atc tac tcc gcg        192
Leu Ser His Ala Val Pro Phe Ser Thr Pro Lys Lys Ile Tyr Ser Ala           
    50                  55                  60                            

aac tat tcg gac tgc cac gac gcg gat ctg gtg gtc gtc acg gct ggg        240
Asn Tyr Ser Asp Cys His Asp Ala Asp Leu Val Val Val Thr Ala Gly           
65                  70                  75                  80            

acc gcc cag aag cct ggc gaa acg cgc ctg gac ttg gtt aac cgc aat        288
Thr Ala Gln Lys Pro Gly Glu Thr Arg Leu Asp Leu Val Asn Arg Asn           
                85                  90                  95                

atc aag atc atg aag ggc ata gtg gac gaa gtc atg gcg agc ggt ttt        336
Ile Lys Ile Met Lys Gly Ile Val Asp Glu Val Met Ala Ser Gly Phe           
            100                 105                 110                   

gac ggc atc ttc ctg atc gcg agc aac ccc gtg gac atc ctg acc tac        384
Asp Gly Ile Phe Leu Ile Ala Ser Asn Pro Val Asp Ile Leu Thr Tyr           
        115                 120                 125                       

gcg acc tgg aag ttc agc ggg ctc ccc aaa gag cgg gtc atc ggc tcg        432
Ala Thr Trp Lys Phe Ser Gly Leu Pro Lys Glu Arg Val Ile Gly Ser           
    130                 135                 140                           

gga acc tca ctc gat acc gca cgc ttc cgg atg agt atc gcc gac tac        480
Gly Thr Ser Leu Asp Thr Ala Arg Phe Arg Met Ser Ile Ala Asp Tyr           
145                 150                 155                 160           

ctg aag gtc gat gcg cgg aat gtt cac ggc tac atc ctg ggg gag cac        528
Leu Lys Val Asp Ala Arg Asn Val His Gly Tyr Ile Leu Gly Glu His           
                165                 170                 175               

ggg gat acg gaa ttc ccg gcc tgg agc cac acc act gtc ggc ggc ttg        576
Gly Asp Thr Glu Phe Pro Ala Trp Ser His Thr Thr Val Gly Gly Leu           
            180                 185                 190                   

ccg atc acc gag tgg atc tcg gaa gat gaa cag ggc gcc atg gac acg        624
Pro Ile Thr Glu Trp Ile Ser Glu Asp Glu Gln Gly Ala Met Asp Thr           
        195                 200                 205                       

atc ttc gtg tcc gtg cgt gat gcc gcc tac gag atc atc aac aaa aag        672
Ile Phe Val Ser Val Arg Asp Ala Ala Tyr Glu Ile Ile Asn Lys Lys           
    210                 215                 220                           

gga gcc acc ttc tat ggc gtc gcg gca gcc ctc gcc cgc atc acg aag        720
Gly Ala Thr Phe Tyr Gly Val Ala Ala Ala Leu Ala Arg Ile Thr Lys           
225                 230                 235                 240           

gcc att ctg aat aac gag aac gcg atc ctg ccg ctg tcg gtc tac ctg        768
Ala Ile Leu Asn Asn Glu Asn Ala Ile Leu Pro Leu Ser Val Tyr Leu           
                245                 250                 255               

gac ggc cat tat ggc atg aac gac atc tat atc ggc gct ccg gcg gtc        816
Asp Gly His Tyr Gly Met Asn Asp Ile Tyr Ile Gly Ala Pro Ala Val           
            260                 265                 270                   

gtg aat cgg cag ggt gtg cga cac atc gtg gag atg aac ctc acc gac        864
Val Asn Arg Gln Gly Val Arg His Ile Val Glu Met Asn Leu Thr Asp           
        275                 280                 285                       

aaa gaa aag gaa cag atg aag aac agc gcg gac acc ctg aaa aag gtc        912
Lys Glu Lys Glu Gln Met Lys Asn Ser Ala Asp Thr Leu Lys Lys Val           
    290                 295                 300                           

ctg gac gac gcc atg aaa caa gtg gac taa                                942
Leu Asp Asp Ala Met Lys Gln Val Asp                                       
305                 310                                                   


<210>  34
<211>  313
<212>  PRT
<213>  Artificial

<220>
<223>  Synthetic Construct

<400>  34

Met Lys Asp His Gln Lys Ile Ile Leu Val Gly Asp Gly Ala Val Gly 
1               5                   10                  15      


Ser Ser Tyr Ala Phe Ala Cys Val Asn Leu Ser Ile Gly Gln Glu Phe 
            20                  25                  30          


Gly Ile Ile Asp Ile Asp Lys Asp Arg Thr Ile Gly Asp Ala Met Asp 
        35                  40                  45              


Leu Ser His Ala Val Pro Phe Ser Thr Pro Lys Lys Ile Tyr Ser Ala 
    50                  55                  60                  


Asn Tyr Ser Asp Cys His Asp Ala Asp Leu Val Val Val Thr Ala Gly 
65                  70                  75                  80  


Thr Ala Gln Lys Pro Gly Glu Thr Arg Leu Asp Leu Val Asn Arg Asn 
                85                  90                  95      


Ile Lys Ile Met Lys Gly Ile Val Asp Glu Val Met Ala Ser Gly Phe 
            100                 105                 110         


Asp Gly Ile Phe Leu Ile Ala Ser Asn Pro Val Asp Ile Leu Thr Tyr 
        115                 120                 125             


Ala Thr Trp Lys Phe Ser Gly Leu Pro Lys Glu Arg Val Ile Gly Ser 
    130                 135                 140                 


Gly Thr Ser Leu Asp Thr Ala Arg Phe Arg Met Ser Ile Ala Asp Tyr 
145                 150                 155                 160 


Leu Lys Val Asp Ala Arg Asn Val His Gly Tyr Ile Leu Gly Glu His 
                165                 170                 175     


Gly Asp Thr Glu Phe Pro Ala Trp Ser His Thr Thr Val Gly Gly Leu 
            180                 185                 190         


Pro Ile Thr Glu Trp Ile Ser Glu Asp Glu Gln Gly Ala Met Asp Thr 
        195                 200                 205             


Ile Phe Val Ser Val Arg Asp Ala Ala Tyr Glu Ile Ile Asn Lys Lys 
    210                 215                 220                 


Gly Ala Thr Phe Tyr Gly Val Ala Ala Ala Leu Ala Arg Ile Thr Lys 
225                 230                 235                 240 


Ala Ile Leu Asn Asn Glu Asn Ala Ile Leu Pro Leu Ser Val Tyr Leu 
                245                 250                 255     


Asp Gly His Tyr Gly Met Asn Asp Ile Tyr Ile Gly Ala Pro Ala Val 
            260                 265                 270         


Val Asn Arg Gln Gly Val Arg His Ile Val Glu Met Asn Leu Thr Asp 
        275                 280                 285             


Lys Glu Lys Glu Gln Met Lys Asn Ser Ala Asp Thr Leu Lys Lys Val 
    290                 295                 300                 


Leu Asp Asp Ala Met Lys Gln Val Asp 
305                 310             


<210>  35
<211>  963
<212>  DNA
<213>  Artificial

<220>
<223>  Synthetic construct (Bacillus subtilis LDH)


<220>
<221>  CDS
<222>  (1)..(963)

<400>  35
atg aac aaa cac gtg aat aaa gtg gcc ctg atc ggc gca ggc ttc gtc         48
Met Asn Lys His Val Asn Lys Val Ala Leu Ile Gly Ala Gly Phe Val           
1               5                   10                  15                

ggg agc tcg tac gcg ttc gcg ctg atc aac cag ggc atc acc gat gag         96
Gly Ser Ser Tyr Ala Phe Ala Leu Ile Asn Gln Gly Ile Thr Asp Glu           
            20                  25                  30                    

ctg gta gtc atc gat gtt aac aaa gaa aag gcc atg ggg gat gtg atg        144
Leu Val Val Ile Asp Val Asn Lys Glu Lys Ala Met Gly Asp Val Met           
        35                  40                  45                        

gac ttg aat cac ggc aag gcc ttt gcc ccg cag ccc gtc aag acg agc        192
Asp Leu Asn His Gly Lys Ala Phe Ala Pro Gln Pro Val Lys Thr Ser           
    50                  55                  60                            

tat ggg acg tac gaa gat tgt aaa gac gcc gac atc gtg tgc atc tgc        240
Tyr Gly Thr Tyr Glu Asp Cys Lys Asp Ala Asp Ile Val Cys Ile Cys           
65                  70                  75                  80            

gct ggc gcc aat cag aag ccg gga gag act cgc ctg gag ctg gtc gag        288
Ala Gly Ala Asn Gln Lys Pro Gly Glu Thr Arg Leu Glu Leu Val Glu           
                85                  90                  95                

aag aac ctg aaa atc ttc aag ggc att gtg tcc gaa gtg atg gcc agc        336
Lys Asn Leu Lys Ile Phe Lys Gly Ile Val Ser Glu Val Met Ala Ser           
            100                 105                 110                   

ggc ttc gac ggc atc ttc ctt atc gcc aca aac ccg gtc gac atc ctg        384
Gly Phe Asp Gly Ile Phe Leu Ile Ala Thr Asn Pro Val Asp Ile Leu           
        115                 120                 125                       

acc tat gcc acc tgg aag ttc tcg ggc ctc cct aag gaa cgc gtc atc        432
Thr Tyr Ala Thr Trp Lys Phe Ser Gly Leu Pro Lys Glu Arg Val Ile           
    130                 135                 140                           

gga tct ggc acc acg ctc gac tcg gcg cgt ttc cgc tac atg ctc tcc        480
Gly Ser Gly Thr Thr Leu Asp Ser Ala Arg Phe Arg Tyr Met Leu Ser           
145                 150                 155                 160           

gaa tac ttc ggc gct gcg ccc caa aac gtc cat gcc cac atc ata ggc        528
Glu Tyr Phe Gly Ala Ala Pro Gln Asn Val His Ala His Ile Ile Gly           
                165                 170                 175               

gag cac ggc gac acc gag ctg ccg gtc tgg tcc cac gcg aac gtg ggt        576
Glu His Gly Asp Thr Glu Leu Pro Val Trp Ser His Ala Asn Val Gly           
            180                 185                 190                   

ggc gtc ccc gtg tcg gag ttg gtg gag aag aat gac gcg tat aag caa        624
Gly Val Pro Val Ser Glu Leu Val Glu Lys Asn Asp Ala Tyr Lys Gln           
        195                 200                 205                       

gaa gaa ctg gac cag atc gtc gat gac gtg aag aac gcg gcc tac cat        672
Glu Glu Leu Asp Gln Ile Val Asp Asp Val Lys Asn Ala Ala Tyr His           
    210                 215                 220                           

atc att gag aag aaa ggc gcg acc tac tac ggt gtc gca atg tcc ctg        720
Ile Ile Glu Lys Lys Gly Ala Thr Tyr Tyr Gly Val Ala Met Ser Leu           
225                 230                 235                 240           

gcg cgg atc acc aag gcc atc ctg cat aac gag aat tca atc ctc acg        768
Ala Arg Ile Thr Lys Ala Ile Leu His Asn Glu Asn Ser Ile Leu Thr           
                245                 250                 255               

gtg agt acc tat ttg gac ggc cag tat ggg gcc gac gat gtc tac atc        816
Val Ser Thr Tyr Leu Asp Gly Gln Tyr Gly Ala Asp Asp Val Tyr Ile           
            260                 265                 270                   

gga gtt cca gcg gta gtc aac cgg ggt ggc atc gcc ggg atc acc gaa        864
Gly Val Pro Ala Val Val Asn Arg Gly Gly Ile Ala Gly Ile Thr Glu           
        275                 280                 285                       

ctc aac ctg aac gaa aag gaa aag gaa cag ttc ctg cac agc gcc ggt        912
Leu Asn Leu Asn Glu Lys Glu Lys Glu Gln Phe Leu His Ser Ala Gly           
    290                 295                 300                           

gtg ctg aag aac att ctg aag ccg cat ttt gcc gag cag aaa gtg aac        960
Val Leu Lys Asn Ile Leu Lys Pro His Phe Ala Glu Gln Lys Val Asn           
305                 310                 315                 320           

taa                                                                    963


<210>  36
<211>  320
<212>  PRT
<213>  Artificial

<220>
<223>  Synthetic Construct

<400>  36

Met Asn Lys His Val Asn Lys Val Ala Leu Ile Gly Ala Gly Phe Val 
1               5                   10                  15      


Gly Ser Ser Tyr Ala Phe Ala Leu Ile Asn Gln Gly Ile Thr Asp Glu 
            20                  25                  30          


Leu Val Val Ile Asp Val Asn Lys Glu Lys Ala Met Gly Asp Val Met 
        35                  40                  45              


Asp Leu Asn His Gly Lys Ala Phe Ala Pro Gln Pro Val Lys Thr Ser 
    50                  55                  60                  


Tyr Gly Thr Tyr Glu Asp Cys Lys Asp Ala Asp Ile Val Cys Ile Cys 
65                  70                  75                  80  


Ala Gly Ala Asn Gln Lys Pro Gly Glu Thr Arg Leu Glu Leu Val Glu 
                85                  90                  95      


Lys Asn Leu Lys Ile Phe Lys Gly Ile Val Ser Glu Val Met Ala Ser 
            100                 105                 110         


Gly Phe Asp Gly Ile Phe Leu Ile Ala Thr Asn Pro Val Asp Ile Leu 
        115                 120                 125             


Thr Tyr Ala Thr Trp Lys Phe Ser Gly Leu Pro Lys Glu Arg Val Ile 
    130                 135                 140                 


Gly Ser Gly Thr Thr Leu Asp Ser Ala Arg Phe Arg Tyr Met Leu Ser 
145                 150                 155                 160 


Glu Tyr Phe Gly Ala Ala Pro Gln Asn Val His Ala His Ile Ile Gly 
                165                 170                 175     


Glu His Gly Asp Thr Glu Leu Pro Val Trp Ser His Ala Asn Val Gly 
            180                 185                 190         


Gly Val Pro Val Ser Glu Leu Val Glu Lys Asn Asp Ala Tyr Lys Gln 
        195                 200                 205             


Glu Glu Leu Asp Gln Ile Val Asp Asp Val Lys Asn Ala Ala Tyr His 
    210                 215                 220                 


Ile Ile Glu Lys Lys Gly Ala Thr Tyr Tyr Gly Val Ala Met Ser Leu 
225                 230                 235                 240 


Ala Arg Ile Thr Lys Ala Ile Leu His Asn Glu Asn Ser Ile Leu Thr 
                245                 250                 255     


Val Ser Thr Tyr Leu Asp Gly Gln Tyr Gly Ala Asp Asp Val Tyr Ile 
            260                 265                 270         


Gly Val Pro Ala Val Val Asn Arg Gly Gly Ile Ala Gly Ile Thr Glu 
        275                 280                 285             


Leu Asn Leu Asn Glu Lys Glu Lys Glu Gln Phe Leu His Ser Ala Gly 
    290                 295                 300                 


Val Leu Lys Asn Ile Leu Lys Pro His Phe Ala Glu Gln Lys Val Asn 
305                 310                 315                 320 


<210>  37
<211>  945
<212>  DNA
<213>  Artificial

<220>
<223>  Synthetic construct (Enterococcus faecium LDH)


<220>
<221>  CDS
<222>  (1)..(945)

<400>  37
atg aag aaa acg agc cgc aaa gtc gtg atc gtc ggg acc ggc ttc gtc         48
Met Lys Lys Thr Ser Arg Lys Val Val Ile Val Gly Thr Gly Phe Val           
1               5                   10                  15                

ggc acc tcc atc gct tac gcc atg atc aat cag ggt att tcg aac gaa         96
Gly Thr Ser Ile Ala Tyr Ala Met Ile Asn Gln Gly Ile Ser Asn Glu           
            20                  25                  30                    

ctg gtg ctg atc gac gtg aat cag gaa aag gcc gaa ggt gag gca ctg        144
Leu Val Leu Ile Asp Val Asn Gln Glu Lys Ala Glu Gly Glu Ala Leu           
        35                  40                  45                        

gat ctg ctg gat ggc atg gcc tgg ggc gac gag aac gtg gcg gtc tgg        192
Asp Leu Leu Asp Gly Met Ala Trp Gly Asp Glu Asn Val Ala Val Trp           
    50                  55                  60                            

agc ggt ggc tat gaa gag tgc aaa gac gcc gac att gtg gtc gtc acc        240
Ser Gly Gly Tyr Glu Glu Cys Lys Asp Ala Asp Ile Val Val Val Thr           
65                  70                  75                  80            

gcc ggt atc aac caa aag ccg gga cag tct agg ttg gat ctg gtc aag        288
Ala Gly Ile Asn Gln Lys Pro Gly Gln Ser Arg Leu Asp Leu Val Lys           
                85                  90                  95                

acg aat gcc tcc atc atg cgg cag atc gtc aaa gaa atc atg ggg tcc        336
Thr Asn Ala Ser Ile Met Arg Gln Ile Val Lys Glu Ile Met Gly Ser           
            100                 105                 110                   

gga ttc gac ggc atc atc gtg gtg gcg tcg aac cct gta gac atc ctc        384
Gly Phe Asp Gly Ile Ile Val Val Ala Ser Asn Pro Val Asp Ile Leu           
        115                 120                 125                       

acc tac atc gcg tgg aac gag tcc ggg ctg ccg acg agc cgg gtg atc        432
Thr Tyr Ile Ala Trp Asn Glu Ser Gly Leu Pro Thr Ser Arg Val Ile           
    130                 135                 140                           

ggg acg ggc acg acc ctg gac acc acc cgg ttc cgg aag gaa atc gcg        480
Gly Thr Gly Thr Thr Leu Asp Thr Thr Arg Phe Arg Lys Glu Ile Ala           
145                 150                 155                 160           

ctc aag ctc aag gtc gac ccc cgc tcg gtc cat ggc tat atc ctg ggc        528
Leu Lys Leu Lys Val Asp Pro Arg Ser Val His Gly Tyr Ile Leu Gly           
                165                 170                 175               

gag cat ggc gac agc gaa gtg gcg gcc tgg agc cac aca acg gtg ggc        576
Glu His Gly Asp Ser Glu Val Ala Ala Trp Ser His Thr Thr Val Gly           
            180                 185                 190                   

ggc aag ccc gtc ttt gag atc gtt gaa aag gac cac cgt atc gcg aaa        624
Gly Lys Pro Val Phe Glu Ile Val Glu Lys Asp His Arg Ile Ala Lys           
        195                 200                 205                       

gac gag ttg gat gtc ata gcc gat aag gtc cgc aac gcg gcc tat gaa        672
Asp Glu Leu Asp Val Ile Ala Asp Lys Val Arg Asn Ala Ala Tyr Glu           
    210                 215                 220                           

atc atc gac cgc aag aaa gcc acc tac tac ggg atc ggc atg tcg acc        720
Ile Ile Asp Arg Lys Lys Ala Thr Tyr Tyr Gly Ile Gly Met Ser Thr           
225                 230                 235                 240           

gcg cgg atc gtg aag gcc ata ctg aat aac gaa cag gcc gtg ctg ccg        768
Ala Arg Ile Val Lys Ala Ile Leu Asn Asn Glu Gln Ala Val Leu Pro           
                245                 250                 255               

gtt tca gct tac ctg acc gga gag tac aac gag aaa gac atc ttc acc        816
Val Ser Ala Tyr Leu Thr Gly Glu Tyr Asn Glu Lys Asp Ile Phe Thr           
            260                 265                 270                   

ggc gtt ccg tcg atc gtg gat gag aac ggc gtg cga gaa gtc gtg gag        864
Gly Val Pro Ser Ile Val Asp Glu Asn Gly Val Arg Glu Val Val Glu           
        275                 280                 285                       

ctc agt att aac gaa gaa gag aaa gcg atg ttc tcc aag agc acc tcc        912
Leu Ser Ile Asn Glu Glu Glu Lys Ala Met Phe Ser Lys Ser Thr Ser           
    290                 295                 300                           

gca ctt cgc gag gta ctg aac act gtc ctc taa                            945
Ala Leu Arg Glu Val Leu Asn Thr Val Leu                                   
305                 310                                                   


<210>  38
<211>  314
<212>  PRT
<213>  Artificial

<220>
<223>  Synthetic Construct

<400>  38

Met Lys Lys Thr Ser Arg Lys Val Val Ile Val Gly Thr Gly Phe Val 
1               5                   10                  15      


Gly Thr Ser Ile Ala Tyr Ala Met Ile Asn Gln Gly Ile Ser Asn Glu 
            20                  25                  30          


Leu Val Leu Ile Asp Val Asn Gln Glu Lys Ala Glu Gly Glu Ala Leu 
        35                  40                  45              


Asp Leu Leu Asp Gly Met Ala Trp Gly Asp Glu Asn Val Ala Val Trp 
    50                  55                  60                  


Ser Gly Gly Tyr Glu Glu Cys Lys Asp Ala Asp Ile Val Val Val Thr 
65                  70                  75                  80  


Ala Gly Ile Asn Gln Lys Pro Gly Gln Ser Arg Leu Asp Leu Val Lys 
                85                  90                  95      


Thr Asn Ala Ser Ile Met Arg Gln Ile Val Lys Glu Ile Met Gly Ser 
            100                 105                 110         


Gly Phe Asp Gly Ile Ile Val Val Ala Ser Asn Pro Val Asp Ile Leu 
        115                 120                 125             


Thr Tyr Ile Ala Trp Asn Glu Ser Gly Leu Pro Thr Ser Arg Val Ile 
    130                 135                 140                 


Gly Thr Gly Thr Thr Leu Asp Thr Thr Arg Phe Arg Lys Glu Ile Ala 
145                 150                 155                 160 


Leu Lys Leu Lys Val Asp Pro Arg Ser Val His Gly Tyr Ile Leu Gly 
                165                 170                 175     


Glu His Gly Asp Ser Glu Val Ala Ala Trp Ser His Thr Thr Val Gly 
            180                 185                 190         


Gly Lys Pro Val Phe Glu Ile Val Glu Lys Asp His Arg Ile Ala Lys 
        195                 200                 205             


Asp Glu Leu Asp Val Ile Ala Asp Lys Val Arg Asn Ala Ala Tyr Glu 
    210                 215                 220                 


Ile Ile Asp Arg Lys Lys Ala Thr Tyr Tyr Gly Ile Gly Met Ser Thr 
225                 230                 235                 240 


Ala Arg Ile Val Lys Ala Ile Leu Asn Asn Glu Gln Ala Val Leu Pro 
                245                 250                 255     


Val Ser Ala Tyr Leu Thr Gly Glu Tyr Asn Glu Lys Asp Ile Phe Thr 
            260                 265                 270         


Gly Val Pro Ser Ile Val Asp Glu Asn Gly Val Arg Glu Val Val Glu 
        275                 280                 285             


Leu Ser Ile Asn Glu Glu Glu Lys Ala Met Phe Ser Lys Ser Thr Ser 
    290                 295                 300                 


Ala Leu Arg Glu Val Leu Asn Thr Val Leu 
305                 310                 


<210>  39
<211>  951
<212>  DNA
<213>  Artificial

<220>
<223>  Synthetic construct (Bacillus thuriengensis LDH)


<220>
<221>  CDS
<222>  (1)..(951)

<400>  39
atg aaa cgg cat acc cgg aaa ata gcc atc atc ggc acg ggc ctg gtg         48
Met Lys Arg His Thr Arg Lys Ile Ala Ile Ile Gly Thr Gly Leu Val           
1               5                   10                  15                

ggg tcc agc tgc gca tac tcc atc gtc aac cag ggt atc tgc gag gaa         96
Gly Ser Ser Cys Ala Tyr Ser Ile Val Asn Gln Gly Ile Cys Glu Glu           
            20                  25                  30                    

ctc ctg ctg atc gac atc aac cac gag cgc gct gtc ggc gag gcg atg        144
Leu Leu Leu Ile Asp Ile Asn His Glu Arg Ala Val Gly Glu Ala Met           
        35                  40                  45                        

gat ctc tcc cat tgc atc aac ttc acg aac acg cgc acc aag gtg tac        192
Asp Leu Ser His Cys Ile Asn Phe Thr Asn Thr Arg Thr Lys Val Tyr           
    50                  55                  60                            

gcg ggg tcg tac gaa gat tgt aaa gac atg gac atc gtt atc att acc        240
Ala Gly Ser Tyr Glu Asp Cys Lys Asp Met Asp Ile Val Ile Ile Thr           
65                  70                  75                  80            

gcg ggt ccg gca ccc aag cct ggc cag tcg cgg ctg gat acg ttg ggc        288
Ala Gly Pro Ala Pro Lys Pro Gly Gln Ser Arg Leu Asp Thr Leu Gly           
                85                  90                  95                

gcc tcc gcc aag atc atg gag agc gtt gtg ggt gga gtc atg gaa tcg        336
Ala Ser Ala Lys Ile Met Glu Ser Val Val Gly Gly Val Met Glu Ser           
            100                 105                 110                   

ggg ttt gac ggc atc ttc ctt ctc gcc agt aat ccg gtg gac atc atc        384
Gly Phe Asp Gly Ile Phe Leu Leu Ala Ser Asn Pro Val Asp Ile Ile           
        115                 120                 125                       

acc tat caa gtc tgg aag ttg tcg ggc ctc ccc agg aat cga gtg atc        432
Thr Tyr Gln Val Trp Lys Leu Ser Gly Leu Pro Arg Asn Arg Val Ile           
    130                 135                 140                           

ggg acc ggc acc agc ctg gac agc tca cgg ctg cgt acc atc ctg tcg        480
Gly Thr Gly Thr Ser Leu Asp Ser Ser Arg Leu Arg Thr Ile Leu Ser           
145                 150                 155                 160           

gaa atg ctg cac gtc gat ccg cgc agc atc cac ggc tac agc ctc ggc        528
Glu Met Leu His Val Asp Pro Arg Ser Ile His Gly Tyr Ser Leu Gly           
                165                 170                 175               

gag cac ggc gac tcg cag atg gtc gcc tgg agt cac gtc acc gtc ggc        576
Glu His Gly Asp Ser Gln Met Val Ala Trp Ser His Val Thr Val Gly           
            180                 185                 190                   

gga aag ccc atc ctg cag atc ctc gaa gaa cag aaa gag cgt ttc ggc        624
Gly Lys Pro Ile Leu Gln Ile Leu Glu Glu Gln Lys Glu Arg Phe Gly           
        195                 200                 205                       

gag att gac ctg gac gag atc gtg gaa aag act gcc aag gcc ggt tgg        672
Glu Ile Asp Leu Asp Glu Ile Val Glu Lys Thr Ala Lys Ala Gly Trp           
    210                 215                 220                           

gag atc tat aag cgc aag ggg aca acg tac tat ggc atc ggc aac tcc        720
Glu Ile Tyr Lys Arg Lys Gly Thr Thr Tyr Tyr Gly Ile Gly Asn Ser           
225                 230                 235                 240           

ctg gcc tat atc gcg tcg tct atc ttc aac gac gac cat cgc gta atc        768
Leu Ala Tyr Ile Ala Ser Ser Ile Phe Asn Asp Asp His Arg Val Ile           
                245                 250                 255               

gcg gtg agc gcc atc ctg gac ggc gag tac ggt gaa tac gat att tgc        816
Ala Val Ser Ala Ile Leu Asp Gly Glu Tyr Gly Glu Tyr Asp Ile Cys           
            260                 265                 270                   

acc ggc gtg ccg gcc att atc acc cgg gat gga ata cgc gaa gtc gtg        864
Thr Gly Val Pro Ala Ile Ile Thr Arg Asp Gly Ile Arg Glu Val Val           
        275                 280                 285                       

gag ttg aac ctg acg gaa gat gaa gag tcc cgg ttc gcg aag tcc aat        912
Glu Leu Asn Leu Thr Glu Asp Glu Glu Ser Arg Phe Ala Lys Ser Asn           
    290                 295                 300                           

gac atc ctg cgc gac tat atg aaa acc atc ggc tac taa                    951
Asp Ile Leu Arg Asp Tyr Met Lys Thr Ile Gly Tyr                           
305                 310                 315                               


<210>  40
<211>  316
<212>  PRT
<213>  Artificial

<220>
<223>  Synthetic Construct

<400>  40

Met Lys Arg His Thr Arg Lys Ile Ala Ile Ile Gly Thr Gly Leu Val 
1               5                   10                  15      


Gly Ser Ser Cys Ala Tyr Ser Ile Val Asn Gln Gly Ile Cys Glu Glu 
            20                  25                  30          


Leu Leu Leu Ile Asp Ile Asn His Glu Arg Ala Val Gly Glu Ala Met 
        35                  40                  45              


Asp Leu Ser His Cys Ile Asn Phe Thr Asn Thr Arg Thr Lys Val Tyr 
    50                  55                  60                  


Ala Gly Ser Tyr Glu Asp Cys Lys Asp Met Asp Ile Val Ile Ile Thr 
65                  70                  75                  80  


Ala Gly Pro Ala Pro Lys Pro Gly Gln Ser Arg Leu Asp Thr Leu Gly 
                85                  90                  95      


Ala Ser Ala Lys Ile Met Glu Ser Val Val Gly Gly Val Met Glu Ser 
            100                 105                 110         


Gly Phe Asp Gly Ile Phe Leu Leu Ala Ser Asn Pro Val Asp Ile Ile 
        115                 120                 125             


Thr Tyr Gln Val Trp Lys Leu Ser Gly Leu Pro Arg Asn Arg Val Ile 
    130                 135                 140                 


Gly Thr Gly Thr Ser Leu Asp Ser Ser Arg Leu Arg Thr Ile Leu Ser 
145                 150                 155                 160 


Glu Met Leu His Val Asp Pro Arg Ser Ile His Gly Tyr Ser Leu Gly 
                165                 170                 175     


Glu His Gly Asp Ser Gln Met Val Ala Trp Ser His Val Thr Val Gly 
            180                 185                 190         


Gly Lys Pro Ile Leu Gln Ile Leu Glu Glu Gln Lys Glu Arg Phe Gly 
        195                 200                 205             


Glu Ile Asp Leu Asp Glu Ile Val Glu Lys Thr Ala Lys Ala Gly Trp 
    210                 215                 220                 


Glu Ile Tyr Lys Arg Lys Gly Thr Thr Tyr Tyr Gly Ile Gly Asn Ser 
225                 230                 235                 240 


Leu Ala Tyr Ile Ala Ser Ser Ile Phe Asn Asp Asp His Arg Val Ile 
                245                 250                 255     


Ala Val Ser Ala Ile Leu Asp Gly Glu Tyr Gly Glu Tyr Asp Ile Cys 
            260                 265                 270         


Thr Gly Val Pro Ala Ile Ile Thr Arg Asp Gly Ile Arg Glu Val Val 
        275                 280                 285             


Glu Leu Asn Leu Thr Glu Asp Glu Glu Ser Arg Phe Ala Lys Ser Asn 
    290                 295                 300                 


Asp Ile Leu Arg Asp Tyr Met Lys Thr Ile Gly Tyr 
305                 310                 315     


<210>  41
<211>  954
<212>  DNA
<213>  Artificial

<220>
<223>  Synthetic construct (Geobacillus stearothermophilus LDH)


<220>
<221>  CDS
<222>  (1)..(954)

<400>  41
atg aag aat aat ggt ggc gca agg gta gtg gta atc gga gcg ggg ttt         48
Met Lys Asn Asn Gly Gly Ala Arg Val Val Val Ile Gly Ala Gly Phe           
1               5                   10                  15                

gtg gga gcg tct tat gtg ttc gcg ctc atg aac cag ggc atc gcc gac         96
Val Gly Ala Ser Tyr Val Phe Ala Leu Met Asn Gln Gly Ile Ala Asp           
            20                  25                  30                    

gag atc gtg ctc atc gac gcc aac gag agc aag gct atc ggc gat gcg        144
Glu Ile Val Leu Ile Asp Ala Asn Glu Ser Lys Ala Ile Gly Asp Ala           
        35                  40                  45                        

atg gac ttc aat cat ggc aag gtc ttt gcg ccc aaa ccg gtg gat atc        192
Met Asp Phe Asn His Gly Lys Val Phe Ala Pro Lys Pro Val Asp Ile           
    50                  55                  60                            

tgg cac ggt gac tac gat gac tgc cgg gac gcc gac ctg gtt gtc atc        240
Trp His Gly Asp Tyr Asp Asp Cys Arg Asp Ala Asp Leu Val Val Ile           
65                  70                  75                  80            

tgc gct ggc gct aac caa aag ccc ggg gaa acc cgg ctg gac ttg gtc        288
Cys Ala Gly Ala Asn Gln Lys Pro Gly Glu Thr Arg Leu Asp Leu Val           
                85                  90                  95                

gat aag aac atc gcg att ttc cga agc atc gtg gag tcc gtc atg gcg        336
Asp Lys Asn Ile Ala Ile Phe Arg Ser Ile Val Glu Ser Val Met Ala           
            100                 105                 110                   

tcg ggc ttc cag ggc ctg ttc ctg gtg gcc aca aac ccg gtc gac ata        384
Ser Gly Phe Gln Gly Leu Phe Leu Val Ala Thr Asn Pro Val Asp Ile           
        115                 120                 125                       

ctc acg tat gcc acc tgg aag ttc tcc gga ctg ccg cac gaa cgg gtc        432
Leu Thr Tyr Ala Thr Trp Lys Phe Ser Gly Leu Pro His Glu Arg Val           
    130                 135                 140                           

atc ggg agc ggt acg att ctg gac acg gca cgc ttc cgc ttc ctg ttg        480
Ile Gly Ser Gly Thr Ile Leu Asp Thr Ala Arg Phe Arg Phe Leu Leu           
145                 150                 155                 160           

ggc gag tac ttc tcg gtc gcc cct cag aac gtc cat gcc tac atc atc        528
Gly Glu Tyr Phe Ser Val Ala Pro Gln Asn Val His Ala Tyr Ile Ile           
                165                 170                 175               

ggc gag cac ggc gat acc gaa ctg cca gtg tgg tcg cag gcc tat atc        576
Gly Glu His Gly Asp Thr Glu Leu Pro Val Trp Ser Gln Ala Tyr Ile           
            180                 185                 190                   

ggc gtc atg ccc atc cgc aaa ctg gtg gag tcg aag ggc gaa gaa gcc        624
Gly Val Met Pro Ile Arg Lys Leu Val Glu Ser Lys Gly Glu Glu Ala           
        195                 200                 205                       

cag aaa gac ctg gaa cgc atc ttc gtc aat gtg cgc gat gca gcg tac        672
Gln Lys Asp Leu Glu Arg Ile Phe Val Asn Val Arg Asp Ala Ala Tyr           
    210                 215                 220                           

cag atc att gaa aag aaa ggg gcc acc tat tac ggg atc gcg atg ggc        720
Gln Ile Ile Glu Lys Lys Gly Ala Thr Tyr Tyr Gly Ile Ala Met Gly           
225                 230                 235                 240           

ctc gcc cgt gtc act cgg gcg atc ctc cac aac gag aac gcc atc ttg        768
Leu Ala Arg Val Thr Arg Ala Ile Leu His Asn Glu Asn Ala Ile Leu           
                245                 250                 255               

acc gtc agc gcc tat ctg gac ggc ctt tac ggc gaa cgc gac gtg tac        816
Thr Val Ser Ala Tyr Leu Asp Gly Leu Tyr Gly Glu Arg Asp Val Tyr           
            260                 265                 270                   

atc ggc gtt ccg gcc gtg atc aat cgg aac ggt atc cgc gag gtg atc        864
Ile Gly Val Pro Ala Val Ile Asn Arg Asn Gly Ile Arg Glu Val Ile           
        275                 280                 285                       

gaa atc gag ctc aac gat gac gag aaa aac cgg ttc cat cac agt gcg        912
Glu Ile Glu Leu Asn Asp Asp Glu Lys Asn Arg Phe His His Ser Ala           
    290                 295                 300                           

gcc acc ctg aag tcc gtc ctg gcc cgt gcc ttc acc cgc taa                954
Ala Thr Leu Lys Ser Val Leu Ala Arg Ala Phe Thr Arg                       
305                 310                 315                               


<210>  42
<211>  317
<212>  PRT
<213>  Artificial

<220>
<223>  Synthetic Construct

<400>  42

Met Lys Asn Asn Gly Gly Ala Arg Val Val Val Ile Gly Ala Gly Phe 
1               5                   10                  15      


Val Gly Ala Ser Tyr Val Phe Ala Leu Met Asn Gln Gly Ile Ala Asp 
            20                  25                  30          


Glu Ile Val Leu Ile Asp Ala Asn Glu Ser Lys Ala Ile Gly Asp Ala 
        35                  40                  45              


Met Asp Phe Asn His Gly Lys Val Phe Ala Pro Lys Pro Val Asp Ile 
    50                  55                  60                  


Trp His Gly Asp Tyr Asp Asp Cys Arg Asp Ala Asp Leu Val Val Ile 
65                  70                  75                  80  


Cys Ala Gly Ala Asn Gln Lys Pro Gly Glu Thr Arg Leu Asp Leu Val 
                85                  90                  95      


Asp Lys Asn Ile Ala Ile Phe Arg Ser Ile Val Glu Ser Val Met Ala 
            100                 105                 110         


Ser Gly Phe Gln Gly Leu Phe Leu Val Ala Thr Asn Pro Val Asp Ile 
        115                 120                 125             


Leu Thr Tyr Ala Thr Trp Lys Phe Ser Gly Leu Pro His Glu Arg Val 
    130                 135                 140                 


Ile Gly Ser Gly Thr Ile Leu Asp Thr Ala Arg Phe Arg Phe Leu Leu 
145                 150                 155                 160 


Gly Glu Tyr Phe Ser Val Ala Pro Gln Asn Val His Ala Tyr Ile Ile 
                165                 170                 175     


Gly Glu His Gly Asp Thr Glu Leu Pro Val Trp Ser Gln Ala Tyr Ile 
            180                 185                 190         


Gly Val Met Pro Ile Arg Lys Leu Val Glu Ser Lys Gly Glu Glu Ala 
        195                 200                 205             


Gln Lys Asp Leu Glu Arg Ile Phe Val Asn Val Arg Asp Ala Ala Tyr 
    210                 215                 220                 


Gln Ile Ile Glu Lys Lys Gly Ala Thr Tyr Tyr Gly Ile Ala Met Gly 
225                 230                 235                 240 


Leu Ala Arg Val Thr Arg Ala Ile Leu His Asn Glu Asn Ala Ile Leu 
                245                 250                 255     


Thr Val Ser Ala Tyr Leu Asp Gly Leu Tyr Gly Glu Arg Asp Val Tyr 
            260                 265                 270         


Ile Gly Val Pro Ala Val Ile Asn Arg Asn Gly Ile Arg Glu Val Ile 
        275                 280                 285             


Glu Ile Glu Leu Asn Asp Asp Glu Lys Asn Arg Phe His His Ser Ala 
    290                 295                 300                 


Ala Thr Leu Lys Ser Val Leu Ala Arg Ala Phe Thr Arg 
305                 310                 315         


<210>  43
<211>  915
<212>  DNA
<213>  Artificial

<220>
<223>  Synthetic construct (Deinococcus radiodurans LDH)


<220>
<221>  CDS
<222>  (1)..(915)

<400>  43
atg aaa gtc ggg gta gtc ggt acg gga ttt gta ggt tca aca gca gcg         48
Met Lys Val Gly Val Val Gly Thr Gly Phe Val Gly Ser Thr Ala Ala           
1               5                   10                  15                

ttc gct ctt gtt ctc agg ggc agc tgc agc gaa ctg gtg ctc gtc gac         96
Phe Ala Leu Val Leu Arg Gly Ser Cys Ser Glu Leu Val Leu Val Asp           
            20                  25                  30                    

cgc gat gaa gat cgg gcc caa gcg gaa gcc gag gac atc gcg cac gcc        144
Arg Asp Glu Asp Arg Ala Gln Ala Glu Ala Glu Asp Ile Ala His Ala           
        35                  40                  45                        

gcc ccg gtg agt cac ggc acc cgc gtg tgg cat ggc ggc cac tcg gaa        192
Ala Pro Val Ser His Gly Thr Arg Val Trp His Gly Gly His Ser Glu           
    50                  55                  60                            

ctc gcg gac gcc cag gtc gtg att ctg acc gca ggc gcc aac cag aaa        240
Leu Ala Asp Ala Gln Val Val Ile Leu Thr Ala Gly Ala Asn Gln Lys           
65                  70                  75                  80            

ccg ggc gag agc cgg ctg gac ctg ttg gag aag aac gcg gac atc ttc        288
Pro Gly Glu Ser Arg Leu Asp Leu Leu Glu Lys Asn Ala Asp Ile Phe           
                85                  90                  95                

cgc gag ctc gtc ccc cag atc acc cgt gcg gct ccc gac gcg gtc ttg        336
Arg Glu Leu Val Pro Gln Ile Thr Arg Ala Ala Pro Asp Ala Val Leu           
            100                 105                 110                   

ctc gtg acc agc aac cct gtc gat ctg ttg acc gac ctg gcc act cag        384
Leu Val Thr Ser Asn Pro Val Asp Leu Leu Thr Asp Leu Ala Thr Gln           
        115                 120                 125                       

ctg gca ccc ggc cag ccg gtg ata ggc tcc ggc acg gtc ctc gac tct        432
Leu Ala Pro Gly Gln Pro Val Ile Gly Ser Gly Thr Val Leu Asp Ser           
    130                 135                 140                           

gcc cgg ttc cga cat ctg atg gcc caa cac gcc ggg gtc gac gga acc        480
Ala Arg Phe Arg His Leu Met Ala Gln His Ala Gly Val Asp Gly Thr           
145                 150                 155                 160           

cat gca cac ggt tat gtg ctg ggc gag cac ggc gat tcc gaa gtg ctg        528
His Ala His Gly Tyr Val Leu Gly Glu His Gly Asp Ser Glu Val Leu           
                165                 170                 175               

gcc tgg tcg tcc gcc atg gtg gcc ggc atg cca gtg gcg gac ttc atg        576
Ala Trp Ser Ser Ala Met Val Ala Gly Met Pro Val Ala Asp Phe Met           
            180                 185                 190                   

cag gcc cag aac ctc ccg tgg aat gaa cag gtt cgc gcg aag atc gac        624
Gln Ala Gln Asn Leu Pro Trp Asn Glu Gln Val Arg Ala Lys Ile Asp           
        195                 200                 205                       

gaa ggc acc cgt aat gcg gcc gcg tcg atc atc gag ggc aaa cgc gcc        672
Glu Gly Thr Arg Asn Ala Ala Ala Ser Ile Ile Glu Gly Lys Arg Ala           
    210                 215                 220                           

acc tat tac ggc atc ggt gcc gcg ctg gcc cgg atc acc gag gcc gtc        720
Thr Tyr Tyr Gly Ile Gly Ala Ala Leu Ala Arg Ile Thr Glu Ala Val           
225                 230                 235                 240           

ctg cgc gat cgc cgt gcc gtg ctg acc gtc agc gct ccg acg ccg gag        768
Leu Arg Asp Arg Arg Ala Val Leu Thr Val Ser Ala Pro Thr Pro Glu           
                245                 250                 255               

tac gga gtg agc ctg tcc ctt ccc cgg gtg gtc gga cgc cag ggc gtc        816
Tyr Gly Val Ser Leu Ser Leu Pro Arg Val Val Gly Arg Gln Gly Val           
            260                 265                 270                   

ttg tcg acg ctc cat ccg aag ctg acg ggg gat gag cag cag aag ctg        864
Leu Ser Thr Leu His Pro Lys Leu Thr Gly Asp Glu Gln Gln Lys Leu           
        275                 280                 285                       

gaa cag tcg gcg ggt gtc ctg cgg ggg ttc aag caa cag ctg ggg ctg        912
Glu Gln Ser Ala Gly Val Leu Arg Gly Phe Lys Gln Gln Leu Gly Leu           
    290                 295                 300                           

taa                                                                    915


<210>  44
<211>  304
<212>  PRT
<213>  Artificial

<220>
<223>  Synthetic Construct

<400>  44

Met Lys Val Gly Val Val Gly Thr Gly Phe Val Gly Ser Thr Ala Ala 
1               5                   10                  15      


Phe Ala Leu Val Leu Arg Gly Ser Cys Ser Glu Leu Val Leu Val Asp 
            20                  25                  30          


Arg Asp Glu Asp Arg Ala Gln Ala Glu Ala Glu Asp Ile Ala His Ala 
        35                  40                  45              


Ala Pro Val Ser His Gly Thr Arg Val Trp His Gly Gly His Ser Glu 
    50                  55                  60                  


Leu Ala Asp Ala Gln Val Val Ile Leu Thr Ala Gly Ala Asn Gln Lys 
65                  70                  75                  80  


Pro Gly Glu Ser Arg Leu Asp Leu Leu Glu Lys Asn Ala Asp Ile Phe 
                85                  90                  95      


Arg Glu Leu Val Pro Gln Ile Thr Arg Ala Ala Pro Asp Ala Val Leu 
            100                 105                 110         


Leu Val Thr Ser Asn Pro Val Asp Leu Leu Thr Asp Leu Ala Thr Gln 
        115                 120                 125             


Leu Ala Pro Gly Gln Pro Val Ile Gly Ser Gly Thr Val Leu Asp Ser 
    130                 135                 140                 


Ala Arg Phe Arg His Leu Met Ala Gln His Ala Gly Val Asp Gly Thr 
145                 150                 155                 160 


His Ala His Gly Tyr Val Leu Gly Glu His Gly Asp Ser Glu Val Leu 
                165                 170                 175     


Ala Trp Ser Ser Ala Met Val Ala Gly Met Pro Val Ala Asp Phe Met 
            180                 185                 190         


Gln Ala Gln Asn Leu Pro Trp Asn Glu Gln Val Arg Ala Lys Ile Asp 
        195                 200                 205             


Glu Gly Thr Arg Asn Ala Ala Ala Ser Ile Ile Glu Gly Lys Arg Ala 
    210                 215                 220                 


Thr Tyr Tyr Gly Ile Gly Ala Ala Leu Ala Arg Ile Thr Glu Ala Val 
225                 230                 235                 240 


Leu Arg Asp Arg Arg Ala Val Leu Thr Val Ser Ala Pro Thr Pro Glu 
                245                 250                 255     


Tyr Gly Val Ser Leu Ser Leu Pro Arg Val Val Gly Arg Gln Gly Val 
            260                 265                 270         


Leu Ser Thr Leu His Pro Lys Leu Thr Gly Asp Glu Gln Gln Lys Leu 
        275                 280                 285             


Glu Gln Ser Ala Gly Val Leu Arg Gly Phe Lys Gln Gln Leu Gly Leu 
    290                 295                 300                 


<210>  45
<211>  948
<212>  DNA
<213>  Artificial

<220>
<223>  Synthetic construct (Plasmodium ovale LDH variant)


<220>
<221>  CDS
<222>  (1)..(948)

<400>  45
atg gca cct aaa ccc aaa att gta cta gtc gga agc ggc atg atc ggc         48
Met Ala Pro Lys Pro Lys Ile Val Leu Val Gly Ser Gly Met Ile Gly           
1               5                   10                  15                

gga gta atg gca acc ctc atc gtc cag aag aat ctg ggc gat gtc gtc         96
Gly Val Met Ala Thr Leu Ile Val Gln Lys Asn Leu Gly Asp Val Val           
            20                  25                  30                    

atg ttc gat atc gtc aag aac atg ccc ctc ggc aag gcc ctg gac acc        144
Met Phe Asp Ile Val Lys Asn Met Pro Leu Gly Lys Ala Leu Asp Thr           
        35                  40                  45                        

tca cat acc aac gtg atg gcc tac tcc aac tgc cag gtg acc ggc agc        192
Ser His Thr Asn Val Met Ala Tyr Ser Asn Cys Gln Val Thr Gly Ser           
    50                  55                  60                            

aat acc tac gag gac ttg aag ggt gcg gac gtg gtg gtg aca gcc ggc        240
Asn Thr Tyr Glu Asp Leu Lys Gly Ala Asp Val Val Val Thr Ala Gly           
65                  70                  75                  80            

ttc acg aag gct ccg ggc aag tcc gac aag gaa tgg aac cgc gac gat        288
Phe Thr Lys Ala Pro Gly Lys Ser Asp Lys Glu Trp Asn Arg Asp Asp           
                85                  90                  95                

ctg ctc ccg ctg aat aac aag att atg atc gag atc ggc ggt cac atc        336
Leu Leu Pro Leu Asn Asn Lys Ile Met Ile Glu Ile Gly Gly His Ile           
            100                 105                 110                   

aag aac tat tgt ccg aac gcg ttc atc atc gtg gtc act aac cca gcc        384
Lys Asn Tyr Cys Pro Asn Ala Phe Ile Ile Val Val Thr Asn Pro Ala           
        115                 120                 125                       

gac gtg atg gtg cag ctg ctg cac cag cat agc ggc gtg agc aag aac        432
Asp Val Met Val Gln Leu Leu His Gln His Ser Gly Val Ser Lys Asn           
    130                 135                 140                           

aag atc gtc ggc ctg ggt ggt gtg ctg gat acc tcc cgg ctg aag tat        480
Lys Ile Val Gly Leu Gly Gly Val Leu Asp Thr Ser Arg Leu Lys Tyr           
145                 150                 155                 160           

tac atc tcg cag aag ctc aat gtc tgc ccc cgt gac gtc aac gcg cac        528
Tyr Ile Ser Gln Lys Leu Asn Val Cys Pro Arg Asp Val Asn Ala His           
                165                 170                 175               

atc gtc ggg gcg cac ggg aac aaa atg gtc gtt ctg aag cgc tat atc        576
Ile Val Gly Ala His Gly Asn Lys Met Val Val Leu Lys Arg Tyr Ile           
            180                 185                 190                   

acc gtg ggg ggc atc ccg ctg caa gag ttc atc aac aac aaa aag atc        624
Thr Val Gly Gly Ile Pro Leu Gln Glu Phe Ile Asn Asn Lys Lys Ile           
        195                 200                 205                       

acc gac gcc gag ctc gat gcg ata ttc gat cgg acg gtc aat acg gcc        672
Thr Asp Ala Glu Leu Asp Ala Ile Phe Asp Arg Thr Val Asn Thr Ala           
    210                 215                 220                           

ctt gag atc gtc aac tac cac gcc agt ccg tac gtg gct ccg gcc gcg        720
Leu Glu Ile Val Asn Tyr His Ala Ser Pro Tyr Val Ala Pro Ala Ala           
225                 230                 235                 240           

gcc atc atc gag atg gcc gag tcg tat ttg aaa gac ctg aaa aaa gtg        768
Ala Ile Ile Glu Met Ala Glu Ser Tyr Leu Lys Asp Leu Lys Lys Val           
                245                 250                 255               

ctg att tgc tcg acc ctg ttg gaa ggc cag tac ggc cat acg ggc gtg        816
Leu Ile Cys Ser Thr Leu Leu Glu Gly Gln Tyr Gly His Thr Gly Val           
            260                 265                 270                   

ttt ggc ggg acg ccc ctg gtc ctc gga tgc aat ggc gtc gaa cag gtt        864
Phe Gly Gly Thr Pro Leu Val Leu Gly Cys Asn Gly Val Glu Gln Val           
        275                 280                 285                       

ttc gaa ctc cag ctg aac gcg gaa gaa aag aaa atg ttc gac gac gcc        912
Phe Glu Leu Gln Leu Asn Ala Glu Glu Lys Lys Met Phe Asp Asp Ala           
    290                 295                 300                           

atc gcc gaa acc aag cgc atg aag gcc ctg gcg taa                        948
Ile Ala Glu Thr Lys Arg Met Lys Ala Leu Ala                               
305                 310                 315                               


<210>  46
<211>  315
<212>  PRT
<213>  Artificial

<220>
<223>  Synthetic Construct

<400>  46

Met Ala Pro Lys Pro Lys Ile Val Leu Val Gly Ser Gly Met Ile Gly 
1               5                   10                  15      


Gly Val Met Ala Thr Leu Ile Val Gln Lys Asn Leu Gly Asp Val Val 
            20                  25                  30          


Met Phe Asp Ile Val Lys Asn Met Pro Leu Gly Lys Ala Leu Asp Thr 
        35                  40                  45              


Ser His Thr Asn Val Met Ala Tyr Ser Asn Cys Gln Val Thr Gly Ser 
    50                  55                  60                  


Asn Thr Tyr Glu Asp Leu Lys Gly Ala Asp Val Val Val Thr Ala Gly 
65                  70                  75                  80  


Phe Thr Lys Ala Pro Gly Lys Ser Asp Lys Glu Trp Asn Arg Asp Asp 
                85                  90                  95      


Leu Leu Pro Leu Asn Asn Lys Ile Met Ile Glu Ile Gly Gly His Ile 
            100                 105                 110         


Lys Asn Tyr Cys Pro Asn Ala Phe Ile Ile Val Val Thr Asn Pro Ala 
        115                 120                 125             


Asp Val Met Val Gln Leu Leu His Gln His Ser Gly Val Ser Lys Asn 
    130                 135                 140                 


Lys Ile Val Gly Leu Gly Gly Val Leu Asp Thr Ser Arg Leu Lys Tyr 
145                 150                 155                 160 


Tyr Ile Ser Gln Lys Leu Asn Val Cys Pro Arg Asp Val Asn Ala His 
                165                 170                 175     


Ile Val Gly Ala His Gly Asn Lys Met Val Val Leu Lys Arg Tyr Ile 
            180                 185                 190         


Thr Val Gly Gly Ile Pro Leu Gln Glu Phe Ile Asn Asn Lys Lys Ile 
        195                 200                 205             


Thr Asp Ala Glu Leu Asp Ala Ile Phe Asp Arg Thr Val Asn Thr Ala 
    210                 215                 220                 


Leu Glu Ile Val Asn Tyr His Ala Ser Pro Tyr Val Ala Pro Ala Ala 
225                 230                 235                 240 


Ala Ile Ile Glu Met Ala Glu Ser Tyr Leu Lys Asp Leu Lys Lys Val 
                245                 250                 255     


Leu Ile Cys Ser Thr Leu Leu Glu Gly Gln Tyr Gly His Thr Gly Val 
            260                 265                 270         


Phe Gly Gly Thr Pro Leu Val Leu Gly Cys Asn Gly Val Glu Gln Val 
        275                 280                 285             


Phe Glu Leu Gln Leu Asn Ala Glu Glu Lys Lys Met Phe Asp Asp Ala 
    290                 295                 300                 


Ile Ala Glu Thr Lys Arg Met Lys Ala Leu Ala 
305                 310                 315 


<210>  47
<211>  933
<212>  DNA
<213>  Artificial

<220>
<223>  Synthetic construct (Thermus thermophilus LDH)


<220>
<221>  CDS
<222>  (1)..(933)

<400>  47
atg aaa gta gga ata gtc ggc tct gga atg gtt gga tcg gca acg gca         48
Met Lys Val Gly Ile Val Gly Ser Gly Met Val Gly Ser Ala Thr Ala           
1               5                   10                  15                

tac gca ctc gca ctc ctc ggc gtg gcg cgg gaa gtc gtg ctg gtc gat         96
Tyr Ala Leu Ala Leu Leu Gly Val Ala Arg Glu Val Val Leu Val Asp           
            20                  25                  30                    

ctc gac cgc aag ctg gcg cag gcc cat gcc gag gat atc ctg cac gcg        144
Leu Asp Arg Lys Leu Ala Gln Ala His Ala Glu Asp Ile Leu His Ala           
        35                  40                  45                        

acc ccg ttc gcg cat ccc gtg tgg gtc cgt gcc ggc agc tat ggc gac        192
Thr Pro Phe Ala His Pro Val Trp Val Arg Ala Gly Ser Tyr Gly Asp           
    50                  55                  60                            

ctg gaa ggg gcg aga gcg gtc gtc ctg gcg gcc ggg gtg gcc cag cgg        240
Leu Glu Gly Ala Arg Ala Val Val Leu Ala Ala Gly Val Ala Gln Arg           
65                  70                  75                  80            

cca ggc gaa acc cgc ctc cag ctg ctc gat cgc aac gcc cag gtg ttt        288
Pro Gly Glu Thr Arg Leu Gln Leu Leu Asp Arg Asn Ala Gln Val Phe           
                85                  90                  95                

gcc caa gtg gta ccg cgg gtt ctg gaa gct gcc ccc gaa gcc gtg ttg        336
Ala Gln Val Val Pro Arg Val Leu Glu Ala Ala Pro Glu Ala Val Leu           
            100                 105                 110                   

ctg gtc gcc acc aat ccc gtc gac gtg atg acc cag gtc gcc tac cgc        384
Leu Val Ala Thr Asn Pro Val Asp Val Met Thr Gln Val Ala Tyr Arg           
        115                 120                 125                       

ctg agc ggt ctg ccg ccg gga agg gtc gtg ggg agc ggc acg atc ctg        432
Leu Ser Gly Leu Pro Pro Gly Arg Val Val Gly Ser Gly Thr Ile Leu           
    130                 135                 140                           

gac aca gcg cgg ttc cgg gcc ttg ctt gcc gag tat ctg cgg gtg gct        480
Asp Thr Ala Arg Phe Arg Ala Leu Leu Ala Glu Tyr Leu Arg Val Ala           
145                 150                 155                 160           

ccg cag tcg gtc cac gcg tac gtg ctc ggc gaa cac ggc gac tcg gaa        528
Pro Gln Ser Val His Ala Tyr Val Leu Gly Glu His Gly Asp Ser Glu           
                165                 170                 175               

gtc ctc gtg tgg agc tcc gcg caa gtc ggg ggt gtg ccg ctt ctg gag        576
Val Leu Val Trp Ser Ser Ala Gln Val Gly Gly Val Pro Leu Leu Glu           
            180                 185                 190                   

ttc gcg gaa gcg cgt ggg cgt gcc cta tcg cct gag gac agg gct cgg        624
Phe Ala Glu Ala Arg Gly Arg Ala Leu Ser Pro Glu Asp Arg Ala Arg           
        195                 200                 205                       

atc gac gag ggc gtg cga cgg gcc gcc tac cgc atc atc gag ggc aag        672
Ile Asp Glu Gly Val Arg Arg Ala Ala Tyr Arg Ile Ile Glu Gly Lys           
    210                 215                 220                           

ggc gcg act tat tac ggc atc ggt gcc ggc ctg gcg cgt ctg gtc cgc        720
Gly Ala Thr Tyr Tyr Gly Ile Gly Ala Gly Leu Ala Arg Leu Val Arg           
225                 230                 235                 240           

gcg atc ttg acc gac gag aaa ggc gtc tat acg gtg tcc gcc ttc acc        768
Ala Ile Leu Thr Asp Glu Lys Gly Val Tyr Thr Val Ser Ala Phe Thr           
                245                 250                 255               

ccc gag gtt gag ggt gtg ctg gaa gtc agt ctg tcc ttg ccg cgc att        816
Pro Glu Val Glu Gly Val Leu Glu Val Ser Leu Ser Leu Pro Arg Ile           
            260                 265                 270                   

ctc ggc gcc ggc ggc gtc gag ggc acc gtg tac ccg tcc ctg tca ccc        864
Leu Gly Ala Gly Gly Val Glu Gly Thr Val Tyr Pro Ser Leu Ser Pro           
        275                 280                 285                       

gag gaa cgc gag gcc ctg cgc cgc agc gcc gaa atc ctc aag gaa gcg        912
Glu Glu Arg Glu Ala Leu Arg Arg Ser Ala Glu Ile Leu Lys Glu Ala           
    290                 295                 300                           

gcg ttc gcc ctg ggt ttc taa                                            933
Ala Phe Ala Leu Gly Phe                                                   
305                 310                                                   


<210>  48
<211>  310
<212>  PRT
<213>  Artificial

<220>
<223>  Synthetic Construct

<400>  48

Met Lys Val Gly Ile Val Gly Ser Gly Met Val Gly Ser Ala Thr Ala 
1               5                   10                  15      


Tyr Ala Leu Ala Leu Leu Gly Val Ala Arg Glu Val Val Leu Val Asp 
            20                  25                  30          


Leu Asp Arg Lys Leu Ala Gln Ala His Ala Glu Asp Ile Leu His Ala 
        35                  40                  45              


Thr Pro Phe Ala His Pro Val Trp Val Arg Ala Gly Ser Tyr Gly Asp 
    50                  55                  60                  


Leu Glu Gly Ala Arg Ala Val Val Leu Ala Ala Gly Val Ala Gln Arg 
65                  70                  75                  80  


Pro Gly Glu Thr Arg Leu Gln Leu Leu Asp Arg Asn Ala Gln Val Phe 
                85                  90                  95      


Ala Gln Val Val Pro Arg Val Leu Glu Ala Ala Pro Glu Ala Val Leu 
            100                 105                 110         


Leu Val Ala Thr Asn Pro Val Asp Val Met Thr Gln Val Ala Tyr Arg 
        115                 120                 125             


Leu Ser Gly Leu Pro Pro Gly Arg Val Val Gly Ser Gly Thr Ile Leu 
    130                 135                 140                 


Asp Thr Ala Arg Phe Arg Ala Leu Leu Ala Glu Tyr Leu Arg Val Ala 
145                 150                 155                 160 


Pro Gln Ser Val His Ala Tyr Val Leu Gly Glu His Gly Asp Ser Glu 
                165                 170                 175     


Val Leu Val Trp Ser Ser Ala Gln Val Gly Gly Val Pro Leu Leu Glu 
            180                 185                 190         


Phe Ala Glu Ala Arg Gly Arg Ala Leu Ser Pro Glu Asp Arg Ala Arg 
        195                 200                 205             


Ile Asp Glu Gly Val Arg Arg Ala Ala Tyr Arg Ile Ile Glu Gly Lys 
    210                 215                 220                 


Gly Ala Thr Tyr Tyr Gly Ile Gly Ala Gly Leu Ala Arg Leu Val Arg 
225                 230                 235                 240 


Ala Ile Leu Thr Asp Glu Lys Gly Val Tyr Thr Val Ser Ala Phe Thr 
                245                 250                 255     


Pro Glu Val Glu Gly Val Leu Glu Val Ser Leu Ser Leu Pro Arg Ile 
            260                 265                 270         


Leu Gly Ala Gly Gly Val Glu Gly Thr Val Tyr Pro Ser Leu Ser Pro 
        275                 280                 285             


Glu Glu Arg Glu Ala Leu Arg Arg Ser Ala Glu Ile Leu Lys Glu Ala 
    290                 295                 300                 


Ala Phe Ala Leu Gly Phe 
305                 310 


<210>  49
<211>  229
<212>  DNA
<213>  Methanococcus capsulatus Bath MDH promoter

<400>  49
tttgcctcga tcggcggtcc ttgtgacagg gagatattcc cgacggatcc ggggcattcg       60

agcggaaccg cccgccgtgg gagtttttcc agcgagcatt cgagagtttt tcaaggcggc      120

ttcgaggggt tattccgtaa cgccgccgac atgatctgtc ccagaatctc cgccgctgtt      180

cgtagagcgc cgatgcaggg tcggcatcaa tcattcttgg aggagacac                  229


<210>  50
<211>  114
<212>  DNA
<213>  Methylosinus trichosporium OB3b promoter region for sga

<400>  50
ttttttgaga ccacgcggcc cgacgcgcaa ggaagctttc gggcgcgcgc gcgtccggcg       60

aagacaactc gaaccgatga gctcgaaggg agccctagac aggaggtaaa aatg            114


<210>  51
<211>  707
<212>  DNA
<213>  Methylmonas sp. 16a maxF promoter

<400>  51
gcgccgtatg ctttcgaatc cgccaagacc gggcatggat aaatccatga ccaccacatc       60

gggcaattgc tttgaataga gttggcaagc ggtctcgcca cgatcggctt catagatctc      120

gccgatacga tccgacagcg atagataggt cttgtagccg gtacgaacca cggcgtgatc      180

atctaccaat aaaacgctga ttttactcgc cactggaaaa tttcctcctc aggtcgtcaa      240

gggataaaga tatgggacaa gtccagtctg atgccaggcg gacttggtgt gccttttttt      300

atgatgacgc tttatccgtg cttaaaccat gggagctttt cccgtttcca atttcgatcc      360

ttggcgagat aggaatattt ccgtgcatga ttgcgtcgat ttcacatcga tttcatggat      420

tgttccgtaa cgttagccag cccggcttct ataacatttg cgccagcgtg gcctggtggt      480

cggtaacccg tgatgcggtt atgatcaaca aagctggttt tcaacgacta attctgatct      540

tcaggtcgcg cctcacttat agcgataaaa atcctggagg aaacatgcaa caactcgatt      600

tgcgcatagt cgggaaaacc gcggccttgt tggctggtgg ccttctgagc gtggcgcaac      660

ccgcatcggc gaacaaggag ctggaacagc tcggaggatt taaaatg                    707


<210>  52
<211>  281
<212>  DNA
<213>  Methylmonas sp. 16a hps promoter

<400>  52
cagatagtaa gcgctaagga ttggggtgcg tcgccggtcg cggcggcgct cctcgacggc       60

agagttggtg ccaggttggc ggatgattga tgccgaatat tacgcgacca attctcgagg      120

caaatgaact gtgagctact gagttgcagg cattgacagc catcccattt ctatcataca      180

gttacggacg catcacgagt aggtgataag cctagcagat tgcggcagtt ggcaaaatca      240

gctattacta ataattaaaa actttcggag cacatcaaat g                          281


<210>  53
<211>  317
<212>  PRT
<213>  Staphylococcus simiae

<400>  53

Met Asn Gln Phe Lys Gly Asn Lys Val Val Leu Ile Gly Asn Gly Ala 
1               5                   10                  15      


Val Gly Ser Ser Tyr Ala Phe Ser Leu Val Asn Gln Ser Ile Val Asp 
            20                  25                  30          


Glu Leu Val Ile Ile Asp Leu Asp Thr Glu Lys Val Lys Gly Asp Val 
        35                  40                  45              


Met Asp Leu Lys His Ala Thr Pro Tyr Ser Pro Thr Thr Val Arg Val 
    50                  55                  60                  


Lys Ala Gly Glu Tyr Ser Asp Cys His Asp Ala Asp Leu Val Val Ile 
65                  70                  75                  80  


Cys Ala Gly Ala Ala Gln Lys Pro Gly Glu Thr Arg Leu Asp Leu Val 
                85                  90                  95      


Ser Lys Asn Leu Lys Ile Phe Lys Ser Ile Val Asp Glu Val Met Ala 
            100                 105                 110         


Ser Gln Phe Asp Gly Ile Phe Leu Val Ala Thr Asn Pro Val Asp Ile 
        115                 120                 125             


Leu Ser Tyr Ala Thr Trp Lys Phe Ser Gly Leu Pro Lys Glu Arg Val 
    130                 135                 140                 


Ile Gly Ser Gly Thr Ile Leu Asp Ser Ala Arg Phe Arg Leu Leu Leu 
145                 150                 155                 160 


Ser Glu Glu Phe Asp Val Ala Pro Ser Ser Val His Ala Gln Ile Ile 
                165                 170                 175     


Gly Glu His Gly Asp Thr Glu Leu Ala Val Trp Ser His Ala Asn Ile 
            180                 185                 190         


Ala Gly Gln Pro Leu Lys Glu Ile Leu Glu Lys Arg Pro Gln Glu Lys 
        195                 200                 205             


Glu Lys Val Glu Gln Ile Phe Val Gln Thr Arg Asp Ala Ala Tyr Asp 
    210                 215                 220                 


Ile Ile Lys Ala Lys Gly Ala Thr Tyr Tyr Gly Val Ala Met Gly Leu 
225                 230                 235                 240 


Thr Arg Ile Thr Glu Ala Ile Phe Arg Asn Glu Asp Ala Val Leu Thr 
                245                 250                 255     


Ile Ser Ala Leu Leu Glu Gly Glu Tyr Gly Gln Glu Asp Leu Tyr Ile 
            260                 265                 270         


Gly Val Pro Ala Val Ile Asn Arg Gly Gly Ile Arg Asn Val Val Glu 
        275                 280                 285             


Thr Pro Leu Asn Glu Glu Glu Arg Thr Gln Phe Ala His Ser Ala His 
    290                 295                 300                 


Thr Leu Lys Asp Ile Met Ser Lys Ala Asp Glu Leu Lys 
305                 310                 315         


<210>  54
<211>  317
<212>  PRT
<213>  Staphylococcus vitulinus

<400>  54

Met Lys Gln Phe Lys Gly Lys Lys Val Val Leu Val Gly Asn Gly Ala 
1               5                   10                  15      


Val Gly Ser Ser Tyr Ala Phe Ser Met Ile Asn Gln Gly Ile Cys Asp 
            20                  25                  30          


Glu Phe Val Ile Ile Asp Leu Asp Lys Lys Lys Val Asn Gly Asp Val 
        35                  40                  45              


Met Asp Leu Asn His Gly Thr Val Tyr Gly Pro Ser Pro Ile Lys Val 
    50                  55                  60                  


Lys Ala Gly Glu Tyr Lys Asp Cys Asn Asp Ala Asp Leu Val Val Ile 
65                  70                  75                  80  


Cys Ala Gly Ala Ala Gln Lys Pro Gly Glu Thr Arg Leu Asp Leu Val 
                85                  90                  95      


Ala Lys Asn Met Lys Ile Phe Lys Ser Ile Val Asp Glu Ile Met Arg 
            100                 105                 110         


Ser Gly Phe Asp Gly Ile Phe Leu Ile Ala Thr Asn Pro Val Asp Val 
        115                 120                 125             


Leu Thr Tyr Ala Thr Met Lys Phe Ser Gly Leu Pro Lys Glu Arg Val 
    130                 135                 140                 


Ile Gly Ser Gly Thr Ile Leu Asp Thr Ala Arg Phe Arg Tyr Leu Leu 
145                 150                 155                 160 


Ser Glu Glu Phe Asp Val Ala Pro Gln Ser Val His Ala Asn Ile Ile 
                165                 170                 175     


Gly Glu His Gly Asp Ser Glu Leu Pro Val Trp Ser His Ala Asn Ile 
            180                 185                 190         


Ala Gly Lys Pro Leu Arg Ser Ile Ile Glu Gln Asp Asp Ser Arg Lys 
        195                 200                 205             


His Arg Val Glu Glu Ile Phe Val Gln Thr Arg Asp Ala Ala Tyr Glu 
    210                 215                 220                 


Ile Ile Glu Ala Lys Gly Ala Thr Tyr Tyr Gly Val Ala Met Gly Leu 
225                 230                 235                 240 


Met Arg Ile Thr Lys Ala Ile Leu Asn Asn Gln Asp Val Val Leu Thr 
                245                 250                 255     


Val Ser Ala Tyr Leu Glu Gly Glu Tyr Gly His Glu Gly Val Tyr Ile 
            260                 265                 270         


Gly Val Pro Ala Leu Ile Asn Arg Ser Gly Ile Lys Glu Val Ile Glu 
        275                 280                 285             


Ile Pro Leu Asp Glu Glu Glu Thr Ser Leu Phe Asn His Ser Val Lys 
    290                 295                 300                 


Val Leu Lys Asp Ile Gln Asp Pro Phe Glu Lys Glu Phe 
305                 310                 315         


<210>  55
<211>  318
<212>  PRT
<213>  Staphylococcus lentus

<400>  55

Met Lys Gln Phe Lys Gly Asn Lys Val Val Leu Val Gly Asn Gly Phe 
1               5                   10                  15      


Val Gly Ser Ser Tyr Ala Phe Ser Met Ile Asn Gln Gly Ile Cys Asp 
            20                  25                  30          


Glu Phe Val Ile Ile Asp Leu Asp Lys Lys Lys Val Asn Gly Asp Val 
        35                  40                  45              


Met Asp Leu Asn His Gly Ser Val Tyr Gly Pro Ser Pro Met Lys Val 
    50                  55                  60                  


Lys Ala Gly Glu Tyr Lys Asp Cys Glu Asp Ala Asp Leu Val Val Ile 
65                  70                  75                  80  


Cys Ala Gly Ala Ala Gln Lys Pro Gly Glu Thr Arg Leu Asp Leu Val 
                85                  90                  95      


Ala Lys Asn Met Lys Ile Phe Lys Asn Ile Val Thr Glu Ile Met Asp 
            100                 105                 110         


Ser Gly Phe Asp Gly Ile Phe Leu Ile Ala Thr Asn Pro Val Asp Ile 
        115                 120                 125             


Leu Ser Tyr Ala Thr Met Lys Phe Ser Gly Leu Pro Lys Glu Arg Val 
    130                 135                 140                 


Ile Gly Ser Gly Thr Ile Leu Asp Thr Ala Arg Phe Lys Tyr Leu Leu 
145                 150                 155                 160 


Ser Glu Glu Phe Asp Val Ala Pro Gln Ser Val His Ala Asn Ile Ile 
                165                 170                 175     


Gly Glu His Gly Asp Ser Glu Leu Ala Val Trp Ser His Ala Asn Ile 
            180                 185                 190         


Ala Gly Lys Pro Leu Arg Ser Ile Ile Glu Lys Asp Glu Thr Arg Lys 
        195                 200                 205             


His Arg Val Glu Glu Ile Phe Val Glu Thr Arg Asp Ala Ala Tyr Glu 
    210                 215                 220                 


Ile Ile Glu Ser Lys Gly Ala Thr Phe Tyr Gly Val Ala Met Gly Leu 
225                 230                 235                 240 


Met Arg Ile Thr Lys Ala Ile Leu Asn Asn Gln Asp Val Val Leu Thr 
                245                 250                 255     


Val Ser Ala Tyr Leu Glu Gly Glu Tyr Gly His Glu Asp Val Tyr Ile 
            260                 265                 270         


Gly Val Pro Ala Leu Val Asn Arg Thr Gly Val Arg Glu Val Ile Glu 
        275                 280                 285             


Met Pro Leu Asn Asp Glu Glu Thr Arg Leu Phe Asp Asn Ser Val Lys 
    290                 295                 300                 


Val Leu Lys Asp Ile Gln Ala Pro Phe Glu Lys Glu Phe Lys 
305                 310                 315             


<210>  56
<211>  315
<212>  PRT
<213>  Macrococcus caseolyticus

<400>  56

Met Glu Lys Phe Lys Gly Asn Lys Val Val Leu Val Gly Asn Gly Ala 
1               5                   10                  15      


Val Gly Ser Ser Tyr Ala Phe Ala Met Leu Asn Gln Gly Ala Cys Asp 
            20                  25                  30          


Glu Phe Val Ile Ile Asp Leu Asn Glu Asp Lys Ala Lys Gly Asp Ala 
        35                  40                  45              


Met Asp Leu Asn His Gly Val Val Tyr Ala Pro Ser Pro Met Gln Val 
    50                  55                  60                  


Lys Tyr Gly Thr Tyr Glu Asp Cys His Asp Ala Ser Leu Ile Val Ile 
65                  70                  75                  80  


Cys Ala Gly Ala Ala Gln Lys Pro Gly Glu Thr Arg Leu Asp Leu Val 
                85                  90                  95      


Gly Lys Asn Met Lys Ile Phe Lys Ser Ile Val Asp Glu Ile Met Lys 
            100                 105                 110         


Ser Gly Phe Asp Gly Ile Phe Leu Ile Ala Thr Asn Pro Val Asp Val 
        115                 120                 125             


Leu Thr Tyr Ala Val Gln Lys Phe Ser Gly Leu Pro Glu Asn Gln Val 
    130                 135                 140                 


Ile Gly Ser Gly Thr Ile Leu Asp Thr Ala Arg Phe Arg His Leu Leu 
145                 150                 155                 160 


Ser Gln Glu Phe Asn Val Ser Pro Asn Ser Val His Gly Tyr Ile Ile 
                165                 170                 175     


Gly Glu His Gly Asp Ser Glu Leu Ala Val Trp Ser Gly Thr Asn Ile 
            180                 185                 190         


Ala Gly Asn Ser Leu Tyr Asp Ile Leu Asn Glu Asn Pro Glu Lys Gln 
        195                 200                 205             


Lys Leu Ile Glu Glu Ile Phe Val Asn Thr Arg Asp Ala Ala Tyr Glu 
    210                 215                 220                 


Ile Ile Lys Ala Lys Gly Ala Thr Tyr Tyr Gly Val Ala Met Gly Leu 
225                 230                 235                 240 


Met Arg Ile Ser Lys Ala Ile Leu Asn Asn Glu Asn Val Val Leu Thr 
                245                 250                 255     


Val Ser Ala Lys Leu Asn Gly Glu Tyr Gly His Asp Asp Val Tyr Ile 
            260                 265                 270         


Gly Val Pro Ala Ile Ile Asn Arg Asn Gly Ile Arg Glu Val Leu Glu 
        275                 280                 285             


Thr Pro Leu Asn Thr Glu Glu Lys Glu Lys Phe Ala Lys Ser Val Glu 
    290                 295                 300                 


Thr Leu Lys Ala Ile Gln Thr Pro Phe Phe Ser 
305                 310                 315 


<210>  57
<211>  314
<212>  PRT
<213>  Bacillus thuringiensis

<400>  57

Met Lys Lys Gly Ile Asn Arg Val Val Leu Val Gly Thr Gly Ala Val 
1               5                   10                  15      


Gly Cys Ser Tyr Ala Tyr Ser Met Ile Asn Gln Gly Val Ala Glu Glu 
            20                  25                  30          


Phe Val Leu Val Asp Val Asn Glu Ala Lys Ala Glu Gly Glu Ala Met 
        35                  40                  45              


Asp Leu Ser His Ala Val Pro Phe Ser Pro Ser Pro Thr Lys Val Trp 
    50                  55                  60                  


Ser Gly Ser Tyr Ala Asp Cys Lys Asp Ala Asp Leu Val Val Ile Thr 
65                  70                  75                  80  


Ala Gly Leu Pro Gln Lys Pro Gly Glu Thr Arg Leu Asp Leu Val Glu 
                85                  90                  95      


Lys Asn Thr Lys Ile Phe Lys Gln Ile Val Arg Gly Ile Met Asp Ser 
            100                 105                 110         


Gly Phe Asp Gly Ile Phe Leu Ile Ala Thr Asn Pro Val Asp Ile Leu 
        115                 120                 125             


Thr Tyr Val Thr Trp Lys Glu Ser Gly Leu Pro Lys Glu Arg Val Ile 
    130                 135                 140                 


Gly Ser Gly Thr Thr Leu Asp Ser Ala Arg Phe Arg Tyr Met Leu Gly 
145                 150                 155                 160 


Asp Tyr Leu Asp Val Asp Pro Arg Asn Val His Ala Tyr Ile Val Gly 
                165                 170                 175     


Glu His Gly Asp Thr Glu Leu Pro Val Trp Ser His Ala Thr Ile Gly 
            180                 185                 190         


Val Gln Lys Leu Glu Thr Ile Leu Ala Asn Asn Glu Gln Tyr Lys Gln 
        195                 200                 205             


Glu Asp Leu Asp Lys Ile Phe Glu Asn Val Arg Asp Ala Ala Tyr His 
    210                 215                 220                 


Ile Ile Glu Arg Lys Gly Ala Thr Tyr Tyr Gly Ile Gly Met Ser Leu 
225                 230                 235                 240 


Leu Arg Val Thr Lys Ala Ile Leu Asn Asn Glu Asn Ser Val Leu Thr 
                245                 250                 255     


Val Ser Ala Tyr Leu Glu Gly Gln Tyr Gly Glu Lys Asp Ala Tyr Val 
            260                 265                 270         


Gly Val Pro Ala Val Ile Asn Arg Glu Gly Val Arg Glu Ile Val Glu 
        275                 280                 285             


Leu Glu Leu Asn Glu Glu Glu Lys Ala Lys Phe Ala His Ser Val Lys 
    290                 295                 300                 


Val Leu Lys Glu Thr Met Ala Pro Val Leu 
305                 310                 


<210>  58
<211>  314
<212>  PRT
<213>  Bacillus thuringiensis

<400>  58

Met Lys Lys Gly Ile Asn Arg Val Val Leu Val Gly Thr Gly Ala Val 
1               5                   10                  15      


Gly Cys Ser Tyr Ala Tyr Ser Met Ile Asn Gln Gly Val Ala Glu Glu 
            20                  25                  30          


Phe Val Leu Val Asp Val Asn Glu Ala Lys Ala Glu Gly Glu Ala Met 
        35                  40                  45              


Asp Leu Ser His Ala Val Pro Phe Ser Pro Ser Pro Thr Lys Val Trp 
    50                  55                  60                  


Ser Gly Ser Tyr Ala Asp Cys Lys Asp Ala Asp Leu Val Val Ile Thr 
65                  70                  75                  80  


Ala Gly Leu Pro Gln Lys Pro Gly Glu Thr Arg Leu Asp Leu Val Glu 
                85                  90                  95      


Lys Asn Thr Lys Ile Phe Lys Gln Ile Val Arg Gly Ile Met Asp Ser 
            100                 105                 110         


Gly Phe Asp Gly Ile Phe Leu Ile Ala Thr Asn Pro Val Asp Ile Leu 
        115                 120                 125             


Thr Tyr Val Thr Trp Lys Glu Ser Gly Leu Pro Lys Glu Arg Val Ile 
    130                 135                 140                 


Gly Ser Gly Thr Thr Leu Asp Ser Ala Arg Phe Arg Tyr Met Leu Gly 
145                 150                 155                 160 


Asp Tyr Leu Asp Val Asp Pro Arg Asn Val His Ala Tyr Ile Val Gly 
                165                 170                 175     


Glu His Gly Asp Thr Glu Leu Pro Val Trp Ser His Ala Thr Ile Gly 
            180                 185                 190         


Val Gln Lys Leu Glu Thr Ile Leu Ala Asn Asn Glu Gln Tyr Asn Gln 
        195                 200                 205             


Glu Asp Leu Asp Lys Ile Phe Glu Asn Val Arg Asp Ala Ala Tyr His 
    210                 215                 220                 


Ile Ile Glu Arg Lys Gly Ala Thr Tyr Tyr Gly Ile Gly Met Ser Leu 
225                 230                 235                 240 


Leu Arg Val Thr Lys Ala Ile Leu Asn Asn Glu Asn Ser Val Leu Thr 
                245                 250                 255     


Val Ser Ala Tyr Leu Glu Gly Gln Tyr Gly Glu Lys Asp Ala Tyr Val 
            260                 265                 270         


Gly Val Pro Ala Val Ile Asn Arg Glu Gly Val Arg Glu Ile Val Glu 
        275                 280                 285             


Leu Glu Leu Asn Glu Asp Glu Lys Ala Lys Phe Ala His Ser Val Lys 
    290                 295                 300                 


Val Leu Lys Glu Thr Met Ala Pro Val Leu 
305                 310                 


<210>  59
<211>  320
<212>  PRT
<213>  Bacillus mycoides

<400>  59

Met Lys Gly Glu Ile Asn Met Lys Lys Gly Ile Asn Arg Val Val Leu 
1               5                   10                  15      


Val Gly Thr Gly Ala Val Gly Cys Ser Tyr Ala Tyr Ser Met Ile Asn 
            20                  25                  30          


Gln Gly Val Ala Glu Glu Phe Val Leu Val Asp Val Asn Glu Ala Lys 
        35                  40                  45              


Ala Glu Gly Glu Ala Met Asp Leu Ser His Ala Val Pro Phe Ser Pro 
    50                  55                  60                  


Ala Pro Thr Lys Val Trp Ser Gly Ser Tyr Ala Asp Cys Lys Asp Ala 
65                  70                  75                  80  


Asp Leu Val Val Ile Thr Ala Gly Leu Pro Gln Lys Pro Gly Glu Thr 
                85                  90                  95      


Arg Leu Asp Leu Val Glu Lys Asn Thr Lys Ile Phe Lys Gln Ile Val 
            100                 105                 110         


Arg Gly Ile Met Asp Ser Gly Phe Asp Gly Ile Phe Leu Ile Ala Thr 
        115                 120                 125             


Asn Pro Val Asp Ile Leu Thr Tyr Val Thr Trp Lys Glu Ser Gly Leu 
    130                 135                 140                 


Pro Lys Glu Arg Val Ile Gly Ser Gly Thr Thr Leu Asp Ser Ala Arg 
145                 150                 155                 160 


Phe Arg Tyr Met Leu Gly Asp Tyr Leu Asp Val Asp Pro Arg Asn Val 
                165                 170                 175     


His Ala Tyr Ile Val Gly Glu His Gly Asp Thr Glu Leu Pro Val Trp 
            180                 185                 190         


Ser His Ala Thr Val Gly Val Gln Lys Leu Glu Thr Ile Leu Ala Asn 
        195                 200                 205             


Asn Glu Gln Tyr Asn Gln Glu Asp Leu Asp Lys Ile Phe Glu Asn Val 
    210                 215                 220                 


Arg Asp Ala Ala Tyr His Ile Ile Glu Arg Lys Gly Ala Thr Tyr Tyr 
225                 230                 235                 240 


Gly Ile Gly Met Ser Leu Leu Arg Val Thr Lys Ala Ile Leu Ser Asn 
                245                 250                 255     


Glu Asn Ser Val Leu Thr Val Ser Ala Tyr Leu Glu Gly Gln Tyr Gly 
            260                 265                 270         


Glu Lys Asp Ala Phe Val Gly Val Pro Ala Val Ile Asn Arg Glu Gly 
        275                 280                 285             


Val Arg Glu Ile Val Glu Leu Glu Leu Asn Glu Glu Glu Lys Ala Lys 
    290                 295                 300                 


Phe Ala His Ser Val Lys Val Leu Lys Glu Thr Met Ala Pro Val Leu 
305                 310                 315                 320 


<210>  60
<211>  312
<212>  PRT
<213>  Lactobacillus rhamnosus

<400>  60

Met Gln His Ser Gly Asn Ile Ile Leu Ile Gly Asp Gly Ala Ile Gly 
1               5                   10                  15      


Ser Ser Phe Ala Phe Asn Cys Leu Thr Thr Gly Val Gly Gln Ser Leu 
            20                  25                  30          


Gly Ile Ile Asp Val Asn Glu Lys Arg Val Gln Gly Asp Val Glu Asp 
        35                  40                  45              


Leu Ser Asp Ala Leu Pro Tyr Thr Ser Gln Lys Asn Ile Tyr Ala Ala 
    50                  55                  60                  


Ser Tyr Glu Asp Cys Lys Tyr Ala Asp Ile Ile Val Ile Thr Ala Gly 
65                  70                  75                  80  


Ile Ala Gln Lys Pro Gly Gln Thr Arg Leu Glu Leu Leu Ser Ile Asn 
                85                  90                  95      


Ala Lys Ile Ile Lys Glu Ile Thr His Asn Ile Met Ala Ser Gly Phe 
            100                 105                 110         


Asn Gly Phe Ile Leu Val Ala Ser Asn Pro Val Asp Val Leu Ala Glu 
        115                 120                 125             


Leu Val Leu Glu Glu Ser Gly Leu Pro Arg Asn Gln Val Leu Gly Ser 
    130                 135                 140                 


Gly Thr Ala Leu Asp Ser Ala Arg Leu Arg Ser Glu Ile Gly Leu Arg 
145                 150                 155                 160 


Tyr Asn Val Asp Ala Arg Ile Val His Gly Tyr Ile Met Gly Glu His 
                165                 170                 175     


Gly Asp Ser Glu Phe Pro Val Trp Asp Tyr Thr Asn Ile Gly Gly Lys 
            180                 185                 190         


Pro Ile Leu Asp Trp Ile Pro Lys Asn Arg Gln Ala Ser Asp Leu Ala 
        195                 200                 205             


Glu Ile Ser His Arg Val Lys Thr Ala Ala Tyr Gly Ile Ile Glu Lys 
    210                 215                 220                 


Lys Gly Ala Thr Phe Tyr Gly Ile Ala Ala Ser Leu Thr Arg Leu Thr 
225                 230                 235                 240 


Ser Ala Phe Leu Asn Asp Asp Arg Ala Ala Phe Ala Met Ser Val His 
                245                 250                 255     


Leu Asp Gly Glu Tyr Gly Leu Ser Gly Val Ser Ile Gly Val Pro Val 
            260                 265                 270         


Ile Leu Gly Ala Asn Gly Leu Glu Arg Ile Ile Glu Leu Asp Leu Asn 
        275                 280                 285             


Ala Glu Asp His Lys Arg Leu Ala Asp Ser Ala Ala Ile Leu Lys Asp 
    290                 295                 300                 


Asn Leu Lys Lys Ala Gln Glu Ala 
305                 310         


<210>  61
<211>  313
<212>  PRT
<213>  Lactobacillus fermentum

<400>  61

Met Ala Arg Lys Val Ala Val Val Gly Met Gly Asn Val Gly Ala Thr 
1               5                   10                  15      


Val Ala His Tyr Leu Val Ala Gly Gly Phe Thr Asp Asp Leu Val Leu 
            20                  25                  30          


Ile Asp Pro Arg Glu Glu Lys Val Val Ala Asp Ala Val Asp Phe Glu 
        35                  40                  45              


Asp Ala Met Ala Asn Leu Glu Tyr His Thr Asn Ile Phe Val Asn Asp 
    50                  55                  60                  


Tyr Glu Ala Leu Ala Asp Ala Asp Val Val Val Ser Ala Leu Gly Asn 
65                  70                  75                  80  


Ile Lys Leu Gln Asp Asn Pro Asp Asp Asp Arg Phe Ala Glu Leu Pro 
                85                  90                  95      


Tyr Thr Arg Val Gln Val Lys Lys Val Ala Thr Lys Leu Lys Glu Val 
            100                 105                 110         


Gly Phe Asn Gly Ile Ile Val Ala Ile Thr Asn Pro Val Asp Val Ile 
        115                 120                 125             


Thr Ser Leu Tyr Gln Glu Ile Thr Gly Leu Pro Lys Asn His Val Ile 
    130                 135                 140                 


Gly Thr Gly Thr Leu Leu Asp Ser Ala Arg Met Lys Arg Ala Val Ala 
145                 150                 155                 160 


Lys Lys Leu Asn Leu Asp Pro Arg Ser Val Ala Gly Tyr Asn Leu Gly 
                165                 170                 175     


Glu His Gly Asn Ser Gln Phe Thr Ala Trp Ser Thr Val Arg Val Leu 
            180                 185                 190         


Gly Lys Pro Ile Glu Gln Ile Ala Asp Gln Lys Gly Leu Asp Leu Val 
        195                 200                 205             


Asp Leu Asp Lys Ala Ala Arg Glu Gly Gly Phe Ile Val Phe Arg Gly 
    210                 215                 220                 


Lys Lys Tyr Thr Ser Tyr Gly Val Ala Thr Ala Ala Val Arg Leu Val 
225                 230                 235                 240 


Asn Thr Ile Leu Ser Asn Ala Leu Thr Glu Leu Pro Val Ser Asn Tyr 
                245                 250                 255     


Arg Glu Glu Tyr Gly Val Tyr Leu Ser Tyr Pro Ala Val Val Gly Arg 
            260                 265                 270         


Asp Gly Ile Val Glu Gln Cys Gln Leu Asp Leu Thr Ala Glu Glu Leu 
        275                 280                 285             


Gln Lys Leu Gln Val Ser Ala Asp Phe Ile Lys Gln Lys Phe Ala Glu 
    290                 295                 300                 


Ser Leu Glu Ala Ala Asp Gln Glu Asp 
305                 310             


<210>  62
<211>  307
<212>  PRT
<213>  Lactobacillus delbrueckii

<400>  62

Met Ser Arg Lys Val Leu Leu Val Gly Asp Gly Ala Val Gly Ser Asn 
1               5                   10                  15      


Phe Ala Asn Asp Leu Leu Gln Thr Thr Arg Val Asp Glu Leu Val Ile 
            20                  25                  30          


Cys Asp Leu Asn Lys Asp Arg Ala Ala Gly Asp Cys Leu Asp Leu Glu 
        35                  40                  45              


Asp Met Thr Tyr Phe Thr Gly Gln Thr Lys Leu Arg Ala Gly Asp Tyr 
    50                  55                  60                  


Ser Asp Ala Ala Asp Ala Asp Val Val Val Ile Thr Ala Gly Val Pro 
65                  70                  75                  80  


Arg Lys Pro Gly Glu Ser Arg Leu Asp Leu Ile Lys Lys Asn Glu Ala 
                85                  90                  95      


Ile Leu Arg Ser Ile Val Asp Pro Val Val Ala Ser Gly Phe Ser Gly 
            100                 105                 110         


Ile Phe Val Val Ser Ala Asn Pro Val Asp Ile Leu Thr Thr Leu Thr 
        115                 120                 125             


Gln Lys Leu Ser Gly Phe Pro Lys Lys Arg Val Ile Gly Thr Gly Thr 
    130                 135                 140                 


Ser Leu Asp Ser Ala Ser Leu Arg Val Glu Leu Ala Lys Arg Leu Gln 
145                 150                 155                 160 


Val Pro Ile Glu Ser Val Asn Ala Trp Val Leu Gly Glu His Gly Asp 
                165                 170                 175     


Ser Ser Phe Glu Asn Phe Ser Ser Ala Val Val Asn Gly Lys Pro Leu 
            180                 185                 190         


Leu Asp Tyr Pro Gly Met Thr Glu Ala Ala Leu Asp Glu Ile Glu Ala 
        195                 200                 205             


His Val Arg Glu Lys Gly Ser Glu Ile Ile Val Lys Lys Gly Ala Thr 
    210                 215                 220                 


Tyr Tyr Gly Val Ala Met Met Leu Ala Lys Ile Val Thr Ala Ile Leu 
225                 230                 235                 240 


Glu Asn Asn Asp Leu Ala Leu Pro Leu Ser Ala Pro Leu His Gly Glu 
                245                 250                 255     


Tyr Gly Ile Lys Asp Glu Ile Tyr Leu Gly Thr Leu Ala Ile Ile Asn 
            260                 265                 270         


Gly Gln Gly Ile Ser His Val Leu Glu Leu Pro Leu Asn Asp Ser Glu 
        275                 280                 285             


Leu Ala Lys Met Arg Ala Ser Ala Ala Thr Ile Lys Ala Thr Leu Asp 
    290                 295                 300                 


Ser Leu Gly 
305         


<210>  63
<211>  325
<212>  PRT
<213>  Lactococcus lactis

<400>  63

Met Ala Asp Lys Gln Arg Lys Lys Val Ile Leu Val Gly Asp Gly Ala 
1               5                   10                  15      


Val Gly Ser Ser Tyr Ala Phe Ala Leu Val Asn Gln Gly Ile Ala Gln 
            20                  25                  30          


Glu Leu Gly Ile Val Asp Leu Phe Lys Glu Lys Thr Gln Gly Asp Ala 
        35                  40                  45              


Glu Asp Leu Ser His Ala Leu Ala Phe Thr Ser Pro Lys Lys Ile Tyr 
    50                  55                  60                  


Ser Ala Asp Tyr Ser Asp Ala Ser Asp Ala Asp Leu Val Val Leu Thr 
65                  70                  75                  80  


Ser Gly Ala Pro Gln Lys Pro Gly Glu Thr Arg Leu Asp Leu Val Glu 
                85                  90                  95      


Lys Asn Leu Arg Ile Thr Lys Asp Val Val Thr Lys Ile Val Ala Ser 
            100                 105                 110         


Gly Phe Lys Gly Ile Phe Leu Val Ala Ala Asn Pro Val Asp Ile Leu 
        115                 120                 125             


Thr Tyr Ala Thr Trp Lys Phe Ser Gly Phe Pro Lys Asn Arg Val Val 
    130                 135                 140                 


Gly Ser Gly Thr Ser Leu Asp Thr Ala Arg Phe Arg Gln Ala Leu Ala 
145                 150                 155                 160 


Glu Lys Val Asp Val Asp Ala Arg Ser Ile His Ala Tyr Ile Met Gly 
                165                 170                 175     


Glu His Gly Asp Ser Glu Phe Ala Val Trp Ser His Ala Asn Val Ala 
            180                 185                 190         


Gly Val Lys Leu Glu Gln Trp Phe Gln Glu Asn Asp Tyr Leu Asn Glu 
        195                 200                 205             


Ala Glu Ile Val Glu Leu Phe Glu Ser Val Arg Asp Ala Ala Tyr Ser 
    210                 215                 220                 


Ile Ile Ala Lys Lys Gly Ala Thr Phe Tyr Gly Val Ala Val Ala Leu 
225                 230                 235                 240 


Ala Arg Ile Thr Lys Ala Ile Leu Asp Asp Glu His Ala Val Leu Pro 
                245                 250                 255     


Val Ser Val Phe Gln Asp Gly Gln Tyr Gly Val Ser Asp Cys Tyr Leu 
            260                 265                 270         


Gly Gln Pro Ala Val Val Gly Ala Glu Gly Val Val Asn Pro Ile His 
        275                 280                 285             


Ile Pro Leu Asn Asp Ala Glu Met Gln Lys Met Glu Ala Ser Gly Ala 
    290                 295                 300                 


Gln Leu Lys Ala Ile Ile Asp Glu Ala Phe Ala Lys Glu Glu Phe Ala 
305                 310                 315                 320 


Ser Ala Val Lys Asn 
                325 


<210>  64
<211>  1014
<212>  DNA
<213>  Lactobacillus helveticus LDH


<220>
<221>  CDS
<222>  (1)..(1014)

<400>  64
atg aca aag gtt ttt gct tac gct att cga aaa gac gaa gaa cca ttc         48
Met Thr Lys Val Phe Ala Tyr Ala Ile Arg Lys Asp Glu Glu Pro Phe           
1               5                   10                  15                

ttg aat gaa tgg aag gaa gct cac aag gat atc gat gtt gat tac act         96
Leu Asn Glu Trp Lys Glu Ala His Lys Asp Ile Asp Val Asp Tyr Thr           
            20                  25                  30                    

gat aaa ctt ttg act cct gaa act gct aag cta gct aag ggt gct gac        144
Asp Lys Leu Leu Thr Pro Glu Thr Ala Lys Leu Ala Lys Gly Ala Asp           
        35                  40                  45                        

ggt gtt gtt gtt tac caa caa tta gac tac act gca gat act ctt caa        192
Gly Val Val Val Tyr Gln Gln Leu Asp Tyr Thr Ala Asp Thr Leu Gln           
    50                  55                  60                            

gct tta gca gac gct ggc gta act aag atg tca tta cgt aac gtt ggt        240
Ala Leu Ala Asp Ala Gly Val Thr Lys Met Ser Leu Arg Asn Val Gly           
65                  70                  75                  80            

gtt gac aac att gat atg gac aag gct aag gaa tta ggt ttc caa att        288
Val Asp Asn Ile Asp Met Asp Lys Ala Lys Glu Leu Gly Phe Gln Ile           
                85                  90                  95                

acc aat gtt cct gtt tac tca cca aac gct att gct gaa cat gct gct        336
Thr Asn Val Pro Val Tyr Ser Pro Asn Ala Ile Ala Glu His Ala Ala           
            100                 105                 110                   

att cag gct gca cgt gta tta cgt caa gac aag cgc atg gac gaa aag        384
Ile Gln Ala Ala Arg Val Leu Arg Gln Asp Lys Arg Met Asp Glu Lys           
        115                 120                 125                       

atg gct aaa cgt gac tta cgt tgg gca cca act atc ggc cgt gaa gtt        432
Met Ala Lys Arg Asp Leu Arg Trp Ala Pro Thr Ile Gly Arg Glu Val           
    130                 135                 140                           

cgt gac caa gtt gtc ggt gtt gtt ggt act ggt cac att ggt caa gta        480
Arg Asp Gln Val Val Gly Val Val Gly Thr Gly His Ile Gly Gln Val           
145                 150                 155                 160           

ttt atg cgt att atg gaa ggt ttc ggt gca aag gtt att gct tac gat        528
Phe Met Arg Ile Met Glu Gly Phe Gly Ala Lys Val Ile Ala Tyr Asp           
                165                 170                 175               

atc ttc aag aac cca gaa ctt gaa aag aag ggt tac tac gtt gac tca        576
Ile Phe Lys Asn Pro Glu Leu Glu Lys Lys Gly Tyr Tyr Val Asp Ser           
            180                 185                 190                   

ctt gac gac ttg tac aag caa gct gat gta att tca ctt cac gta cca        624
Leu Asp Asp Leu Tyr Lys Gln Ala Asp Val Ile Ser Leu His Val Pro           
        195                 200                 205                       

gat gtt cca gct aac gtt cac atg atc aac gac aag tca atc gct gaa        672
Asp Val Pro Ala Asn Val His Met Ile Asn Asp Lys Ser Ile Ala Glu           
    210                 215                 220                           

atg aaa gac ggc gtt gta att gta aac tgc tca cgt ggt cga ctt gtt        720
Met Lys Asp Gly Val Val Ile Val Asn Cys Ser Arg Gly Arg Leu Val           
225                 230                 235                 240           

gac act gac gct gta atc cgt ggt ttg gac tca ggc aag atc ttc ggc        768
Asp Thr Asp Ala Val Ile Arg Gly Leu Asp Ser Gly Lys Ile Phe Gly           
                245                 250                 255               

ttc gtt atg gat act tac gaa gac gaa gtt ggt gta ttt aac aag gat        816
Phe Val Met Asp Thr Tyr Glu Asp Glu Val Gly Val Phe Asn Lys Asp           
            260                 265                 270                   

tgg gaa ggt aaa gaa ttc cca gac aag cgt ttg gca gac tta att gat        864
Trp Glu Gly Lys Glu Phe Pro Asp Lys Arg Leu Ala Asp Leu Ile Asp           
        275                 280                 285                       

cgt cca aac gta ttg gta act cca cac acc gcc ttc tac act act cac        912
Arg Pro Asn Val Leu Val Thr Pro His Thr Ala Phe Tyr Thr Thr His           
    290                 295                 300                           

gct gta cgt aac atg gtt gtt aag gca ttc aac aac aac ttg aag tta        960
Ala Val Arg Asn Met Val Val Lys Ala Phe Asn Asn Asn Leu Lys Leu           
305                 310                 315                 320           

atc aac ggc gaa aag cca gat tct cca gtt gct ttg aac aag aac aag       1008
Ile Asn Gly Glu Lys Pro Asp Ser Pro Val Ala Leu Asn Lys Asn Lys           
                325                 330                 335               

ttt taa                                                               1014
Phe                                                                       
                                                                          


<210>  65
<211>  337
<212>  PRT
<213>  Lactobacillus helveticus LDH

<400>  65

Met Thr Lys Val Phe Ala Tyr Ala Ile Arg Lys Asp Glu Glu Pro Phe 
1               5                   10                  15      


Leu Asn Glu Trp Lys Glu Ala His Lys Asp Ile Asp Val Asp Tyr Thr 
            20                  25                  30          


Asp Lys Leu Leu Thr Pro Glu Thr Ala Lys Leu Ala Lys Gly Ala Asp 
        35                  40                  45              


Gly Val Val Val Tyr Gln Gln Leu Asp Tyr Thr Ala Asp Thr Leu Gln 
    50                  55                  60                  


Ala Leu Ala Asp Ala Gly Val Thr Lys Met Ser Leu Arg Asn Val Gly 
65                  70                  75                  80  


Val Asp Asn Ile Asp Met Asp Lys Ala Lys Glu Leu Gly Phe Gln Ile 
                85                  90                  95      


Thr Asn Val Pro Val Tyr Ser Pro Asn Ala Ile Ala Glu His Ala Ala 
            100                 105                 110         


Ile Gln Ala Ala Arg Val Leu Arg Gln Asp Lys Arg Met Asp Glu Lys 
        115                 120                 125             


Met Ala Lys Arg Asp Leu Arg Trp Ala Pro Thr Ile Gly Arg Glu Val 
    130                 135                 140                 


Arg Asp Gln Val Val Gly Val Val Gly Thr Gly His Ile Gly Gln Val 
145                 150                 155                 160 


Phe Met Arg Ile Met Glu Gly Phe Gly Ala Lys Val Ile Ala Tyr Asp 
                165                 170                 175     


Ile Phe Lys Asn Pro Glu Leu Glu Lys Lys Gly Tyr Tyr Val Asp Ser 
            180                 185                 190         


Leu Asp Asp Leu Tyr Lys Gln Ala Asp Val Ile Ser Leu His Val Pro 
        195                 200                 205             


Asp Val Pro Ala Asn Val His Met Ile Asn Asp Lys Ser Ile Ala Glu 
    210                 215                 220                 


Met Lys Asp Gly Val Val Ile Val Asn Cys Ser Arg Gly Arg Leu Val 
225                 230                 235                 240 


Asp Thr Asp Ala Val Ile Arg Gly Leu Asp Ser Gly Lys Ile Phe Gly 
                245                 250                 255     


Phe Val Met Asp Thr Tyr Glu Asp Glu Val Gly Val Phe Asn Lys Asp 
            260                 265                 270         


Trp Glu Gly Lys Glu Phe Pro Asp Lys Arg Leu Ala Asp Leu Ile Asp 
        275                 280                 285             


Arg Pro Asn Val Leu Val Thr Pro His Thr Ala Phe Tyr Thr Thr His 
    290                 295                 300                 


Ala Val Arg Asn Met Val Val Lys Ala Phe Asn Asn Asn Leu Lys Leu 
305                 310                 315                 320 


Ile Asn Gly Glu Lys Pro Asp Ser Pro Val Ala Leu Asn Lys Asn Lys 
                325                 330                 335     


Phe 
    


<210>  66
<211>  996
<212>  DNA
<213>  Leuconostoc mesenteroides LDH


<220>
<221>  CDS
<222>  (1)..(996)

<400>  66
atg aag att ttt gct tac ggc att cgt gat gat gaa aag cca tca ctt         48
Met Lys Ile Phe Ala Tyr Gly Ile Arg Asp Asp Glu Lys Pro Ser Leu           
1               5                   10                  15                

gaa gaa tgg aaa gcg gct aac cca gag att gaa gtg gac tac aca caa         96
Glu Glu Trp Lys Ala Ala Asn Pro Glu Ile Glu Val Asp Tyr Thr Gln           
            20                  25                  30                    

gag cta ttg aca cct gaa aca gtt aag ttg gct gag gga tca gat tca        144
Glu Leu Leu Thr Pro Glu Thr Val Lys Leu Ala Glu Gly Ser Asp Ser           
        35                  40                  45                        

gct gtt gtt tac caa caa ctg gac tat aca cgt gaa aca ttg aca gct        192
Ala Val Val Tyr Gln Gln Leu Asp Tyr Thr Arg Glu Thr Leu Thr Ala           
    50                  55                  60                            

tta gct aac gtt ggt ggt act aac ttg tca ttg cgt aac gtt ggt aca        240
Leu Ala Asn Val Gly Gly Thr Asn Leu Ser Leu Arg Asn Val Gly Thr           
65                  70                  75                  80            

gat aac att gat ttt gat gca gca cgt gaa ttt aac ttt aac att tca        288
Asp Asn Ile Asp Phe Asp Ala Ala Arg Glu Phe Asn Phe Asn Ile Ser           
                85                  90                  95                

aat gtt cct gtt tat tca cca aat gct att gca gaa cac tca atg att        336
Asn Val Pro Val Tyr Ser Pro Asn Ala Ile Ala Glu His Ser Met Ile           
            100                 105                 110                   

caa tta tct cgt ttg cta cgt cgc acg aaa gca ttg gat gcc aaa att        384
Gln Leu Ser Arg Leu Leu Arg Arg Thr Lys Ala Leu Asp Ala Lys Ile           
        115                 120                 125                       

gct aag cac gac ttg cgc tgg gca cca aca att gga cgt gaa atg cgt        432
Ala Lys His Asp Leu Arg Trp Ala Pro Thr Ile Gly Arg Glu Met Arg           
    130                 135                 140                           

atg caa aca gtt ggt gtt att ggt aca ggc cat att ggc cgt gtt gct        480
Met Gln Thr Val Gly Val Ile Gly Thr Gly His Ile Gly Arg Val Ala           
145                 150                 155                 160           

att aac att ttg aaa ggc ttt ggg gca aag gtt att gct tat gat aag        528
Ile Asn Ile Leu Lys Gly Phe Gly Ala Lys Val Ile Ala Tyr Asp Lys           
                165                 170                 175               

tac cca aat gct gaa ttg caa gca gaa ggt ttg tac gtt gac aca tta        576
Tyr Pro Asn Ala Glu Leu Gln Ala Glu Gly Leu Tyr Val Asp Thr Leu           
            180                 185                 190                   

gac gaa tta tat gca caa gct gat gca att tca ttg tat gtt cct ggt        624
Asp Glu Leu Tyr Ala Gln Ala Asp Ala Ile Ser Leu Tyr Val Pro Gly           
        195                 200                 205                       

gtg cct gaa aac cat cat cta atc aat gca gag gct att gct aag atg        672
Val Pro Glu Asn His His Leu Ile Asn Ala Glu Ala Ile Ala Lys Met           
    210                 215                 220                           

aat gat ggc gtg gtt atc atg aat gct gcg cgt ggt aat ttg atg gac        720
Asn Asp Gly Val Val Ile Met Asn Ala Ala Arg Gly Asn Leu Met Asp           
225                 230                 235                 240           

att gat gct att att gat ggt ttg aat tct ggt aag att tca gac ttc        768
Ile Asp Ala Ile Ile Asp Gly Leu Asn Ser Gly Lys Ile Ser Asp Phe           
                245                 250                 255               

ggt atg gac gtt tat gaa aat gaa gtt ggc ttg ttc aat gaa gat tgg        816
Gly Met Asp Val Tyr Glu Asn Glu Val Gly Leu Phe Asn Glu Asp Trp           
            260                 265                 270                   

tct ggt aaa gaa ttc cca gat gct aag att gct gac ttg att tca cgc        864
Ser Gly Lys Glu Phe Pro Asp Ala Lys Ile Ala Asp Leu Ile Ser Arg           
        275                 280                 285                       

gaa aat gta ttg gtt acg cca cat acg gct ttc tat aca act aaa gct        912
Glu Asn Val Leu Val Thr Pro His Thr Ala Phe Tyr Thr Thr Lys Ala           
    290                 295                 300                           

gtt cta gaa atg gtt cac caa tca ttt gat gca gca gtt gct ttc gcc        960
Val Leu Glu Met Val His Gln Ser Phe Asp Ala Ala Val Ala Phe Ala           
305                 310                 315                 320           

aaa ggt gag aag cca gct att gct gtt gaa tat taa                        996
Lys Gly Glu Lys Pro Ala Ile Ala Val Glu Tyr                               
                325                 330                                   


<210>  67
<211>  331
<212>  PRT
<213>  Leuconostoc mesenteroides LDH

<400>  67

Met Lys Ile Phe Ala Tyr Gly Ile Arg Asp Asp Glu Lys Pro Ser Leu 
1               5                   10                  15      


Glu Glu Trp Lys Ala Ala Asn Pro Glu Ile Glu Val Asp Tyr Thr Gln 
            20                  25                  30          


Glu Leu Leu Thr Pro Glu Thr Val Lys Leu Ala Glu Gly Ser Asp Ser 
        35                  40                  45              


Ala Val Val Tyr Gln Gln Leu Asp Tyr Thr Arg Glu Thr Leu Thr Ala 
    50                  55                  60                  


Leu Ala Asn Val Gly Gly Thr Asn Leu Ser Leu Arg Asn Val Gly Thr 
65                  70                  75                  80  


Asp Asn Ile Asp Phe Asp Ala Ala Arg Glu Phe Asn Phe Asn Ile Ser 
                85                  90                  95      


Asn Val Pro Val Tyr Ser Pro Asn Ala Ile Ala Glu His Ser Met Ile 
            100                 105                 110         


Gln Leu Ser Arg Leu Leu Arg Arg Thr Lys Ala Leu Asp Ala Lys Ile 
        115                 120                 125             


Ala Lys His Asp Leu Arg Trp Ala Pro Thr Ile Gly Arg Glu Met Arg 
    130                 135                 140                 


Met Gln Thr Val Gly Val Ile Gly Thr Gly His Ile Gly Arg Val Ala 
145                 150                 155                 160 


Ile Asn Ile Leu Lys Gly Phe Gly Ala Lys Val Ile Ala Tyr Asp Lys 
                165                 170                 175     


Tyr Pro Asn Ala Glu Leu Gln Ala Glu Gly Leu Tyr Val Asp Thr Leu 
            180                 185                 190         


Asp Glu Leu Tyr Ala Gln Ala Asp Ala Ile Ser Leu Tyr Val Pro Gly 
        195                 200                 205             


Val Pro Glu Asn His His Leu Ile Asn Ala Glu Ala Ile Ala Lys Met 
    210                 215                 220                 


Asn Asp Gly Val Val Ile Met Asn Ala Ala Arg Gly Asn Leu Met Asp 
225                 230                 235                 240 


Ile Asp Ala Ile Ile Asp Gly Leu Asn Ser Gly Lys Ile Ser Asp Phe 
                245                 250                 255     


Gly Met Asp Val Tyr Glu Asn Glu Val Gly Leu Phe Asn Glu Asp Trp 
            260                 265                 270         


Ser Gly Lys Glu Phe Pro Asp Ala Lys Ile Ala Asp Leu Ile Ser Arg 
        275                 280                 285             


Glu Asn Val Leu Val Thr Pro His Thr Ala Phe Tyr Thr Thr Lys Ala 
    290                 295                 300                 


Val Leu Glu Met Val His Gln Ser Phe Asp Ala Ala Val Ala Phe Ala 
305                 310                 315                 320 


Lys Gly Glu Lys Pro Ala Ile Ala Val Glu Tyr 
                325                 330     


