                               SEQUENCE LISTING

<110> THE BRIGHAM AND WOMEN'S HOSPITAL, INC.
      PRESIDENT AND FELLOWS OF HARVARD COLLEGE 
      BIOGEN IDEC MA INC.

<120> FC RECEPTOR (FCRN) BINDING PEPTIDES AND USES THEREOF

<130> 043214-077231-PCT

<140>
<141>

<150> 61/836,279
<151> 2013-06-18

<160> 124   

<170> PatentIn version 3.5

<210> 1
<211> 17
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      peptide

<400> 1
Arg Tyr Phe Cys Thr Lys Trp Lys His Gly Trp Cys Glu Glu Val Gly 
1               5                   10                  15      


Thr 
    


<210> 2
<211> 37
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      polypeptide

<400> 2
Arg Tyr Phe Cys Thr Lys Trp Lys His Gly Trp Cys Glu Glu Val Gly 
1               5                   10                  15      


Thr Gly Gly Gly Arg Tyr Phe Cys Thr Lys Trp Lys His Gly Trp Cys 
            20                  25                  30          


Glu Glu Val Gly Thr 
        35          


<210> 3
<211> 23
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      peptide

<400> 3
Ala Gly Arg Tyr Phe Cys Thr Lys Trp Lys His Gly Trp Cys Glu Glu 
1               5                   10                  15      


Val Gly Thr Gly Gly Gly Lys 
            20              


<210> 4
<211> 23
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      peptide

<400> 4
Ala Gly Val Met His Cys Phe Trp Asp Glu Glu Phe Lys Cys Asp Gln 
1               5                   10                  15      


Gly Gly Thr Gly Gly Gly Lys 
            20              


<210> 5
<211> 23
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      peptide

<400> 5
Ala Gly Tyr Met Thr Cys Lys Trp Asp Asp Gly Phe Ser Cys Glu Tyr 
1               5                   10                  15      


Val Gly Thr Gly Gly Gly Lys 
            20              


<210> 6
<211> 23
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      peptide

<400> 6
Ala Gly Val Met Lys Cys Trp Trp Asp Glu Glu Met Leu Cys Arg Ala 
1               5                   10                  15      


Phe Gly Thr Gly Gly Gly Lys 
            20              


<210> 7
<211> 17
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      peptide


<220>
<221> MOD_RES
<222> (1)..(1)
<223> Any amino acid or absent

<220>
<221> MOD_RES
<222> (3)..(3)
<223> Any amino acid or absent

<220>
<221> MOD_RES
<222> (5)..(6)
<223> Any amino acid or absent

<220>
<221> MOD_RES
<222> (8)..(10)
<223> Any amino acid or absent

<220>
<221> MOD_RES
<222> (13)..(14)
<223> Any amino acid or absent

<220>
<221> MOD_RES
<222> (16)..(17)
<223> Any amino acid or absent

<220> 
<223> see specification as filed for detailed description of
      substitutions and preferred embodiments

<400> 7
Xaa Tyr Xaa Cys Xaa Xaa Trp Xaa Xaa Xaa Trp Cys Xaa Xaa Val Xaa 
1               5                   10                  15      


Xaa 
    


<210> 8
<211> 585
<212> PRT
<213> Homo sapiens

<400> 8
Asp Ala His Lys Ser Glu Val Ala His Arg Phe Lys Asp Leu Gly Glu 
1               5                   10                  15      


Glu Asn Phe Lys Ala Leu Val Leu Ile Ala Phe Ala Gln Tyr Leu Gln 
            20                  25                  30          


Gln Cys Pro Phe Glu Asp His Val Lys Leu Val Asn Glu Val Thr Glu 
        35                  40                  45              


Phe Ala Lys Thr Cys Val Ala Asp Glu Ser Ala Glu Asn Cys Asp Lys 
    50                  55                  60                  


Ser Leu His Thr Leu Phe Gly Asp Lys Leu Cys Thr Val Ala Thr Leu 
65                  70                  75                  80  


Arg Glu Thr Tyr Gly Glu Met Ala Asp Cys Cys Ala Lys Gln Glu Pro 
                85                  90                  95      


Glu Arg Asn Glu Cys Phe Leu Gln His Lys Asp Asp Asn Pro Asn Leu 
            100                 105                 110         


Pro Arg Leu Val Arg Pro Glu Val Asp Val Met Cys Thr Ala Phe His 
        115                 120                 125             


Asp Asn Glu Glu Thr Phe Leu Lys Lys Tyr Leu Tyr Glu Ile Ala Arg 
    130                 135                 140                 


Arg His Pro Tyr Phe Tyr Ala Pro Glu Leu Leu Phe Phe Ala Lys Arg 
145                 150                 155                 160 


Tyr Lys Ala Ala Phe Thr Glu Cys Cys Gln Ala Ala Asp Lys Ala Ala 
                165                 170                 175     


Cys Leu Leu Pro Lys Leu Asp Glu Leu Arg Asp Glu Gly Lys Ala Ser 
            180                 185                 190         


Ser Ala Lys Gln Arg Leu Lys Cys Ala Ser Leu Gln Lys Phe Gly Glu 
        195                 200                 205             


Arg Ala Phe Lys Ala Trp Ala Val Ala Arg Leu Ser Gln Arg Phe Pro 
    210                 215                 220                 


Lys Ala Glu Phe Ala Glu Val Ser Lys Leu Val Thr Asp Leu Thr Lys 
225                 230                 235                 240 


Val His Thr Glu Cys Cys His Gly Asp Leu Leu Glu Cys Ala Asp Asp 
                245                 250                 255     


Arg Ala Asp Leu Ala Lys Tyr Ile Cys Glu Asn Gln Asp Ser Ile Ser 
            260                 265                 270         


Ser Lys Leu Lys Glu Cys Cys Glu Lys Pro Leu Leu Glu Lys Ser His 
        275                 280                 285             


Cys Ile Ala Glu Val Glu Asn Asp Glu Met Pro Ala Asp Leu Pro Ser 
    290                 295                 300                 


Leu Ala Ala Asp Phe Val Glu Ser Lys Asp Val Cys Lys Asn Tyr Ala 
305                 310                 315                 320 


Glu Ala Lys Asp Val Phe Leu Gly Met Phe Leu Tyr Glu Tyr Ala Arg 
                325                 330                 335     


Arg His Pro Asp Tyr Ser Val Val Leu Leu Leu Arg Leu Ala Lys Thr 
            340                 345                 350         


Tyr Glu Thr Thr Leu Glu Lys Cys Cys Ala Ala Ala Asp Pro His Glu 
        355                 360                 365             


Cys Tyr Ala Lys Val Phe Asp Glu Phe Lys Pro Leu Val Glu Glu Pro 
    370                 375                 380                 


Gln Asn Leu Ile Lys Gln Asn Cys Glu Leu Phe Glu Gln Leu Gly Glu 
385                 390                 395                 400 


Tyr Lys Phe Gln Asn Ala Leu Leu Val Arg Tyr Thr Lys Lys Val Pro 
                405                 410                 415     


Gln Val Ser Thr Pro Thr Leu Val Glu Val Ser Arg Asn Leu Gly Lys 
            420                 425                 430         


Val Gly Ser Lys Cys Cys Lys His Pro Glu Ala Lys Arg Met Pro Cys 
        435                 440                 445             


Ala Glu Asp Tyr Leu Ser Val Val Leu Asn Gln Leu Cys Val Leu His 
    450                 455                 460                 


Glu Lys Thr Pro Val Ser Asp Arg Val Thr Lys Cys Cys Thr Glu Ser 
465                 470                 475                 480 


Leu Val Asn Arg Arg Pro Cys Phe Ser Ala Leu Glu Val Asp Glu Thr 
                485                 490                 495     


Tyr Val Pro Lys Glu Phe Asn Ala Glu Thr Phe Thr Phe His Ala Asp 
            500                 505                 510         


Ile Cys Thr Leu Ser Glu Lys Glu Arg Gln Ile Lys Lys Gln Thr Ala 
        515                 520                 525             


Leu Val Glu Leu Val Lys His Lys Pro Lys Ala Thr Lys Glu Gln Leu 
    530                 535                 540                 


Lys Ala Val Met Asp Asp Phe Ala Ala Phe Val Glu Lys Cys Cys Lys 
545                 550                 555                 560 


Ala Asp Asp Lys Glu Thr Cys Phe Ala Glu Glu Gly Lys Lys Leu Val 
                565                 570                 575     


Ala Ala Ser Gln Ala Ala Leu Gly Leu 
            580                 585 


<210> 9
<211> 17
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      peptide


<220>
<221> MOD_RES
<222> (1)..(1) 
<223> Arg or a conservative amino acid substitution of Arg

<220>
<221> MOD_RES
<222> (3)..(3) 
<223> Phe or a conservative amino acid substitution of Phe

<220>
<221> MOD_RES
<222> (5)..(5) 
<223> Thr or a conservative amino acid substitution of Thr

<220>
<221> MOD_RES
<222> (6)..(6) 
<223> Lys or a conservative amino acid substitution of Lys

<220>
<221> MOD_RES
<222> (8)..(8) 
<223> His or a conservative amino acid substitution of His

<220>
<221> MOD_RES
<222> (9)..(9) 
<223> Gly or a conservative amino acid substitution of Gly

<220>
<221> MOD_RES
<222> (10)..(10) 
<223> Cys or a conservative amino acid substitution of Cys

<220>
<221> MOD_RES
<222> (13)..(14) 
<223> Glu or a conservative amino acid substitution of Glu

<220>
<221> MOD_RES
<222> (16)..(16) 
<223> Gly, a conservative amino acid substitution of Gly 
      or absent

<220>
<221> MOD_RES
<222> (17)..(17) 
<223> Thr, a conservative amino acid substitution of Thr 
      or absent

<220> 
<223> see specification as filed for detailed description of
      substitutions and preferred embodiments

<400> 9
Xaa Tyr Xaa Cys Xaa Xaa Trp Xaa Xaa Xaa Trp Cys Xaa Xaa Val Xaa 
1               5                   10                  15      


Xaa 
    


<210> 10
<211> 17
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      peptide


<220>
<221> MOD_RES
<222> (5)..(6)
<223> Any amino acid or absent

<220>
<221> MOD_RES
<222> (8)..(10)
<223> Any amino acid or absent

<220>
<221> MOD_RES
<222> (13)..(14)
<223> Any amino acid or absent

<220>
<221> MOD_RES
<222> (16)..(17)
<223> Any amino acid or absent

<220> 
<223> see specification as filed for detailed description of
      substitutions and preferred embodiments

<400> 10
Arg Tyr Phe Cys Xaa Xaa Trp Xaa Xaa Xaa Trp Cys Xaa Xaa Val Xaa 
1               5                   10                  15      


Xaa 
    


<210> 11
<211> 17
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      peptide


<220>
<221> MOD_RES
<222> (5)..(5) 
<223> Thr or a conservative amino acid substitution of Thr

<220>
<221> MOD_RES
<222> (6)..(6) 
<223> Lys or a conservative amino acid substitution of Lys

<220>
<221> MOD_RES
<222> (8)..(8) 
<223> His or a conservative amino acid substitution of His

<220>
<221> MOD_RES
<222> (9)..(9) 
<223> Gly or a conservative amino acid substitution of Gly

<220>
<221> MOD_RES
<222> (10)..(10) 
<223> Cys or a conservative amino acid substitution of Cys

<220>
<221> MOD_RES
<222> (13)..(14) 
<223> Glu or a conservative amino acid substitution of Glu

<220>
<221> MOD_RES
<222> (16)..(16) 
<223> Gly, a conservative amino acid substitution of Gly 
      or absent

<220>
<221> MOD_RES
<222> (17)..(17) 
<223> Thr, a conservative amino acid substitution of Thr 
      or absent

<220> 
<223> see specification as filed for detailed description of
      substitutions and preferred embodiments

<400> 11
Arg Tyr Phe Cys Xaa Xaa Trp Xaa Xaa Xaa Trp Cys Xaa Xaa Val Xaa 
1               5                   10                  15      


Xaa 
    


<210> 12
<211> 17
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      peptide


<220>
<221> MOD_RES
<222> (5)..(6)
<223> Any amino acid or absent

<220>
<221> MOD_RES
<222> (8)..(9)
<223> Any amino acid or absent

<220>
<221> MOD_RES
<222> (13)..(14)
<223> Any amino acid or absent

<220>
<221> MOD_RES
<222> (17)..(17)
<223> Any amino acid or absent

<220> 
<223> see specification as filed for detailed description of
      substitutions and preferred embodiments

<400> 12
Arg Tyr Phe Cys Xaa Xaa Trp Xaa Xaa Gly Trp Cys Xaa Xaa Val Glu 
1               5                   10                  15      


Xaa 
    


<210> 13
<211> 17
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      peptide


<220>
<221> MOD_RES
<222> (5)..(5) 
<223> Thr or a conservative amino acid substitution of Thr

<220>
<221> MOD_RES
<222> (6)..(6) 
<223> Lys or a conservative amino acid substitution of Lys

<220>
<221> MOD_RES
<222> (8)..(8) 
<223> His or a conservative amino acid substitution of His

<220>
<221> MOD_RES
<222> (9)..(9) 
<223> Gly or a conservative amino acid substitution of Gly

<220>
<221> MOD_RES
<222> (13)..(14) 
<223> Glu or a conservative amino acid substitution of Glu

<220>
<221> MOD_RES
<222> (17)..(17) 
<223> Thr, a conservative amino acid substitution of Thr 
      or absent

<220> 
<223> see specification as filed for detailed description of
      substitutions and preferred embodiments

<400> 13
Arg Tyr Phe Cys Xaa Xaa Trp Xaa Xaa Gly Trp Cys Xaa Xaa Val Glu 
1               5                   10                  15      


Xaa 
    


<210> 14
<211> 10
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      peptide


<220>
<221> misc_feature
<222> (1)..(10)
<223> This sequence may encompass 1-10 'Gly' residues, wherein
      some positions may be absent

<220> 
<223> see specification as filed for detailed description of
      substitutions and preferred embodiments

<400> 14
Gly Gly Gly Gly Gly Gly Gly Gly Gly Gly 
1               5                   10  


<210> 15
<211> 10
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      peptide


<220>
<221> MOD_RES
<222> (1)..(10)
<223> Gly or Ser

<220>
<221> misc_feature
<222> (1)..(10)
<223> This sequence may encompass 1-10 residues, wherein some
      positions may be absent

<220> 
<223> see specification as filed for detailed description of
      substitutions and preferred embodiments

<400> 15
Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa 
1               5                   10  


<210> 16
<211> 5
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      peptide


<220>
<221> misc_feature
<222> (1)..(5)
<223> This sequence may encompass 3-5 'Gly' residues, wherein
      some positions may be absent

<220> 
<223> see specification as filed for detailed description of
      substitutions and preferred embodiments

<400> 16
Gly Gly Gly Gly Gly 
1               5   


<210> 17
<211> 5
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      peptide


<220>
<221> MOD_RES
<222> (1)..(5)
<223> Gly or Ser

<220>
<221> misc_feature
<222> (1)..(5)
<223> This sequence may encompass 3-5 residues, wherein some
      positions may be absent

<220> 
<223> see specification as filed for detailed description of
      substitutions and preferred embodiments

<400> 17
Xaa Xaa Xaa Xaa Xaa 
1               5   


<210> 18
<211> 15
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      peptide

<400> 18
Arg Tyr Phe Cys Thr Lys Trp Lys His Gly Trp Cys Glu Glu Val 
1               5                   10                  15  


<210> 19
<211> 15
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      peptide

<400> 19
Ala Tyr Phe Cys Thr Lys Trp Lys His Gly Trp Cys Glu Glu Val 
1               5                   10                  15  


<210> 20
<211> 15
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      peptide

<400> 20
Arg Ala Phe Cys Thr Lys Trp Lys His Gly Trp Cys Glu Glu Val 
1               5                   10                  15  


<210> 21
<211> 15
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      peptide

<400> 21
Arg Tyr Ala Cys Thr Lys Trp Lys His Gly Trp Cys Glu Glu Val 
1               5                   10                  15  


<210> 22
<211> 15
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      peptide

<400> 22
Arg Tyr Phe Cys Ala Lys Trp Lys His Gly Trp Cys Glu Glu Val 
1               5                   10                  15  


<210> 23
<211> 15
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      peptide

<400> 23
Arg Tyr Phe Cys Thr Ala Trp Lys His Gly Trp Cys Glu Glu Val 
1               5                   10                  15  


<210> 24
<211> 15
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      peptide

<400> 24
Arg Tyr Phe Cys Thr Lys Ala Lys His Gly Trp Cys Glu Glu Val 
1               5                   10                  15  


<210> 25
<211> 15
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      peptide

<400> 25
Arg Tyr Phe Cys Thr Lys Trp Ala His Gly Trp Cys Glu Glu Val 
1               5                   10                  15  


<210> 26
<211> 15
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      peptide

<400> 26
Arg Tyr Phe Cys Thr Lys Trp Lys Ala Gly Trp Cys Glu Glu Val 
1               5                   10                  15  


<210> 27
<211> 15
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      peptide

<400> 27
Arg Tyr Phe Cys Thr Lys Trp Lys His Ala Trp Cys Glu Glu Val 
1               5                   10                  15  


<210> 28
<211> 15
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      peptide

<400> 28
Arg Tyr Phe Cys Thr Lys Trp Lys His Gly Ala Cys Glu Glu Val 
1               5                   10                  15  


<210> 29
<211> 15
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      peptide

<400> 29
Arg Tyr Phe Cys Thr Lys Trp Lys His Gly Trp Cys Ala Glu Val 
1               5                   10                  15  


<210> 30
<211> 15
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      peptide

<400> 30
Arg Tyr Phe Cys Thr Lys Trp Lys His Gly Trp Cys Glu Ala Val 
1               5                   10                  15  


<210> 31
<211> 15
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      peptide

<400> 31
Arg Tyr Phe Cys Thr Lys Trp Lys His Gly Trp Cys Glu Glu Ala 
1               5                   10                  15  


<210> 32
<211> 15
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      peptide


<220>
<221> MOD_RES
<222> (4)..(4)
<223> Pen

<400> 32
Arg Tyr Phe Xaa Thr Lys Trp Lys His Gly Trp Cys Glu Glu Val 
1               5                   10                  15  


<210> 33
<211> 15
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      peptide


<220>
<221> MOD_RES
<222> (12)..(12)
<223> Pen

<400> 33
Arg Tyr Phe Cys Thr Lys Trp Lys His Gly Trp Xaa Glu Glu Val 
1               5                   10                  15  


<210> 34
<211> 15
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      peptide


<220>
<221> MOD_RES
<222> (4)..(4)
<223> Pen

<220>
<221> MOD_RES
<222> (12)..(12)
<223> Pen

<400> 34
Arg Tyr Phe Xaa Thr Lys Trp Lys His Gly Trp Xaa Glu Glu Val 
1               5                   10                  15  


<210> 35
<211> 15
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      peptide

<400> 35
Arg Tyr Phe Ala Thr Lys Trp Lys His Gly Trp Ala Glu Glu Val 
1               5                   10                  15  


<210> 36
<211> 22
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      peptide

<400> 36
Gly Arg Tyr Phe Cys Thr Lys Trp Lys His Gly Trp Cys Glu Glu Val 
1               5                   10                  15      


Gly Thr Gly Gly Gly Lys 
            20          


<210> 37
<211> 21
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      peptide

<400> 37
Arg Tyr Phe Cys Thr Lys Trp Lys His Gly Trp Cys Glu Glu Val Gly 
1               5                   10                  15      


Thr Gly Gly Gly Lys 
            20      


<210> 38
<211> 22
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      peptide

<400> 38
Ala Gly Arg Tyr Phe Cys Thr Lys Trp Lys His Gly Trp Cys Glu Glu 
1               5                   10                  15      


Val Gly Thr Gly Gly Gly 
            20          


<210> 39
<211> 21
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      peptide

<400> 39
Ala Gly Arg Tyr Phe Cys Thr Lys Trp Lys His Gly Trp Cys Glu Glu 
1               5                   10                  15      


Val Gly Thr Gly Gly 
            20      


<210> 40
<211> 20
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      peptide

<400> 40
Ala Gly Arg Tyr Phe Cys Thr Lys Trp Lys His Gly Trp Cys Glu Glu 
1               5                   10                  15      


Val Gly Thr Gly 
            20  


<210> 41
<211> 19
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      peptide

<400> 41
Ala Gly Arg Tyr Phe Cys Thr Lys Trp Lys His Gly Trp Cys Glu Glu 
1               5                   10                  15      


Val Gly Thr 
            


<210> 42
<211> 18
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      peptide

<400> 42
Ala Gly Arg Tyr Phe Cys Thr Lys Trp Lys His Gly Trp Cys Glu Glu 
1               5                   10                  15      


Val Gly 
        


<210> 43
<211> 17
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      peptide

<400> 43
Ala Gly Arg Tyr Phe Cys Thr Lys Trp Lys His Gly Trp Cys Glu Glu 
1               5                   10                  15      


Val 
    


<210> 44
<211> 15
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      peptide

<400> 44
Val Met His Cys Phe Trp Asp Glu Glu Phe Lys Cys Asp Gln Gly 
1               5                   10                  15  


<210> 45
<211> 15
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      peptide

<400> 45
Val Met Ala Cys Phe Trp Asp Glu Glu Phe Lys Cys Asp Gln Gly 
1               5                   10                  15  


<210> 46
<211> 15
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      peptide

<400> 46
Val Met His Cys Phe Trp Asp Glu Ala Phe Lys Cys Asp Gln Gly 
1               5                   10                  15  


<210> 47
<211> 15
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      peptide

<400> 47
Val Met His Cys Ala Trp Asp Glu Glu Phe Lys Cys Asp Gln Gly 
1               5                   10                  15  


<210> 48
<211> 15
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      peptide

<400> 48
Tyr Met His Cys Phe Trp Asp Glu Glu Phe Lys Cys Asp Gln Gly 
1               5                   10                  15  


<210> 49
<211> 15
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      peptide

<400> 49
Val Met His Cys Phe Trp Asp Glu Gly Phe Lys Cys Asp Gln Gly 
1               5                   10                  15  


<210> 50
<211> 15
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      peptide

<400> 50
Val Met His Cys Phe Trp Asp Glu Glu Phe Lys Cys Glu Gln Gly 
1               5                   10                  15  


<210> 51
<211> 15
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      peptide

<400> 51
Val Met His Cys Phe Trp Asp Glu Glu Phe Lys Cys Asp Tyr Gly 
1               5                   10                  15  


<210> 52
<211> 15
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      peptide

<400> 52
Val Met His Cys Phe Trp Asp Glu Glu Phe Lys Cys Asp Gln Val 
1               5                   10                  15  


<210> 53
<211> 15
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      peptide

<400> 53
Val Met His Cys Phe Trp Asp Glu Glu Phe Arg Cys Asp Tyr Gly 
1               5                   10                  15  


<210> 54
<211> 15
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      peptide

<400> 54
Val Met His Cys Phe Trp Asp Glu Ala Phe Arg Cys Asp Gln Gly 
1               5                   10                  15  


<210> 55
<211> 15
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      peptide

<400> 55
Val Met His Cys Phe Trp Asp Glu Glu Phe Arg Cys Glu Tyr Val 
1               5                   10                  15  


<210> 56
<211> 15
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      peptide

<400> 56
Tyr Met Thr Cys Lys Trp Asp Asp Gly Phe Ser Cys Glu Tyr Val 
1               5                   10                  15  


<210> 57
<211> 15
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      peptide

<400> 57
Ala Met Thr Cys Lys Trp Asp Asp Gly Phe Ser Cys Glu Tyr Val 
1               5                   10                  15  


<210> 58
<211> 15
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      peptide

<400> 58
Tyr Ala Thr Cys Lys Trp Asp Asp Gly Phe Ser Cys Glu Tyr Val 
1               5                   10                  15  


<210> 59
<211> 15
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      peptide

<400> 59
Tyr Met Ala Cys Lys Trp Asp Asp Gly Phe Ser Cys Glu Tyr Val 
1               5                   10                  15  


<210> 60
<211> 15
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      peptide

<400> 60
Tyr Met Thr Cys Ala Trp Asp Asp Gly Phe Ser Cys Glu Tyr Val 
1               5                   10                  15  


<210> 61
<211> 15
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      peptide

<400> 61
Tyr Met Thr Cys Lys Ala Asp Asp Gly Phe Ser Cys Glu Tyr Val 
1               5                   10                  15  


<210> 62
<211> 15
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      peptide

<400> 62
Tyr Met Thr Cys Lys Trp Ala Asp Gly Phe Ser Cys Glu Tyr Val 
1               5                   10                  15  


<210> 63
<211> 15
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      peptide

<400> 63
Tyr Met Thr Cys Lys Trp Asp Ala Gly Phe Ser Cys Glu Tyr Val 
1               5                   10                  15  


<210> 64
<211> 15
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      peptide

<400> 64
Tyr Met Thr Cys Lys Trp Asp Asp Ala Phe Ser Cys Glu Tyr Val 
1               5                   10                  15  


<210> 65
<211> 15
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      peptide

<400> 65
Tyr Met Thr Cys Lys Trp Asp Asp Gly Ala Ser Cys Glu Tyr Val 
1               5                   10                  15  


<210> 66
<211> 15
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      peptide

<400> 66
Tyr Met Thr Cys Lys Trp Asp Asp Gly Phe Ala Cys Glu Tyr Val 
1               5                   10                  15  


<210> 67
<211> 15
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      peptide

<400> 67
Tyr Met Thr Cys Lys Trp Asp Asp Gly Phe Ser Cys Ala Tyr Val 
1               5                   10                  15  


<210> 68
<211> 15
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      peptide

<400> 68
Tyr Met Thr Cys Lys Trp Asp Asp Gly Phe Ser Cys Glu Ala Val 
1               5                   10                  15  


<210> 69
<211> 15
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      peptide

<400> 69
Tyr Met Thr Cys Lys Trp Asp Asp Gly Phe Ser Cys Glu Tyr Ala 
1               5                   10                  15  


<210> 70
<211> 15
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      peptide

<400> 70
Tyr Met Thr Ala Lys Trp Asp Asp Gly Phe Ser Ala Glu Tyr Val 
1               5                   10                  15  


<210> 71
<211> 14
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      peptide

<400> 71
Met Thr Cys Lys Trp Asp Asp Gly Phe Ser Cys Glu Tyr Val 
1               5                   10                  


<210> 72
<211> 13
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      peptide

<400> 72
Thr Cys Lys Trp Asp Asp Gly Phe Ser Cys Glu Tyr Val 
1               5                   10              


<210> 73
<211> 12
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      peptide

<400> 73
Cys Lys Trp Asp Asp Gly Phe Ser Cys Glu Tyr Val 
1               5                   10          


<210> 74
<211> 14
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      peptide

<400> 74
Tyr Met Thr Cys Lys Trp Asp Asp Gly Phe Ser Cys Glu Tyr 
1               5                   10                  


<210> 75
<211> 13
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      peptide

<400> 75
Tyr Met Thr Cys Lys Trp Asp Asp Gly Phe Ser Cys Glu 
1               5                   10              


<210> 76
<211> 12
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      peptide

<400> 76
Tyr Met Thr Cys Lys Trp Asp Asp Gly Phe Ser Cys 
1               5                   10          


<210> 77
<211> 15
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      peptide


<220>
<221> MOD_RES
<222> (4)..(4)
<223> Pen

<400> 77
Tyr Met Thr Xaa Lys Trp Asp Asp Gly Phe Ser Cys Glu Tyr Val 
1               5                   10                  15  


<210> 78
<211> 15
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      peptide


<220>
<221> MOD_RES
<222> (12)..(12)
<223> Pen

<400> 78
Tyr Met Thr Cys Lys Trp Asp Asp Gly Phe Ser Xaa Glu Tyr Val 
1               5                   10                  15  


<210> 79
<211> 15
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      peptide


<220>
<221> MOD_RES
<222> (4)..(4)
<223> Pen

<220>
<221> MOD_RES
<222> (12)..(12)
<223> Pen

<400> 79
Tyr Met Thr Xaa Lys Trp Asp Asp Gly Phe Ser Xaa Glu Tyr Val 
1               5                   10                  15  


<210> 80
<211> 15
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      peptide

<400> 80
Val Met Lys Cys Trp Trp Asp Glu Glu Met Leu Cys Arg Ala Phe 
1               5                   10                  15  


<210> 81
<211> 15
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      peptide

<400> 81
Val Met His Cys Trp Trp Asp Glu Glu Met Leu Cys Arg Ala Phe 
1               5                   10                  15  


<210> 82
<211> 15
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      peptide

<400> 82
Val Met Arg Cys Trp Trp Asp Glu Glu Met Leu Cys Arg Ala Phe 
1               5                   10                  15  


<210> 83
<211> 15
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      peptide

<400> 83
Val Met Lys Cys Phe Trp Asp Glu Glu Met Leu Cys Arg Ala Phe 
1               5                   10                  15  


<210> 84
<211> 15
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      peptide

<400> 84
Val Met Lys Cys Trp Trp Asp Glu Glu Phe Leu Cys Arg Ala Phe 
1               5                   10                  15  


<210> 85
<211> 15
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      peptide

<400> 85
Val Met Lys Cys Trp Trp Asp Glu Glu Met Arg Cys Arg Ala Phe 
1               5                   10                  15  


<210> 86
<211> 15
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      peptide

<400> 86
Val Met Lys Cys Trp Trp Asp Glu Glu Met Leu Cys Glu Ala Phe 
1               5                   10                  15  


<210> 87
<211> 15
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      peptide

<400> 87
Val Met Lys Cys Trp Trp Asp Glu Glu Met Leu Cys Arg Tyr Phe 
1               5                   10                  15  


<210> 88
<211> 15
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      peptide

<400> 88
Val Met Lys Cys Trp Trp Asp Glu Glu Met Leu Cys Arg Ala Val 
1               5                   10                  15  


<210> 89
<211> 15
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      peptide

<400> 89
Val Met Lys Cys Trp Trp Asp Glu Glu Met Leu Cys Arg Ala Val 
1               5                   10                  15  


<210> 90
<211> 15
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      peptide

<400> 90
Val Met His Ala Phe Trp Asp Glu Glu Phe Arg Ala Glu Tyr Val 
1               5                   10                  15  


<210> 91
<211> 10
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      peptide

<400> 91
His Thr His Gly Met Asp Glu Leu Lys Tyr 
1               5                   10  


<210> 92
<211> 4
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      peptide

<400> 92
Gly Gly Ser Gly 
1               


<210> 93
<211> 8
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      peptide

<400> 93
Gly Gly Ser Gly Gly Gly Ser Gly 
1               5               


<210> 94
<211> 12
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      peptide

<400> 94
Gly Gly Ser Gly Gly Gly Ser Gly Gly Gly Ser Gly 
1               5                   10          


<210> 95
<211> 15
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      peptide

<400> 95
Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser 
1               5                   10                  15  


<210> 96
<211> 6
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      peptide

<400> 96
Gly Gly Ser Gly Gly Ser 
1               5       


<210> 97
<211> 60
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide

<400> 97
gaagctgctg caagagaagc tgcagctagg gaggctgcag ctagggaggc tgctgcaaga       60


<210> 98
<211> 18
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide

<400> 98
ggtagcggca gcggtagc                                                     18


<210> 99
<211> 30
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide

<400> 99
ggtagcggca gcggtagcgg tagcggcagc                                        30


<210> 100
<211> 30
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide

<400> 100
ggtgaaaatt tgtattttca atctggtggt                                        30


<210> 101
<211> 24
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide

<400> 101
tccgcttgtt actgtgagct ttcc                                              24


<210> 102
<211> 51
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide

<400> 102
cgaccagcct gtaagattcc aaatgacctg aagcagaaag ttatgaatca c                51


<210> 103
<211> 45
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide

<400> 103
ggtggaggag gttctggagg cggtggaagt ggtggcggag gtagc                       45


<210> 104
<211> 12
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide

<400> 104
ggtggttctg gt                                                           12


<210> 105
<211> 24
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide

<400> 105
ggtggttctg gtggtggttc tggt                                              24


<210> 106
<211> 36
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide

<400> 106
ggtggttctg gtggtggttc tggtggtggt tctggt                                 36


<210> 107
<211> 108
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      polynucleotide

<400> 107
ggtggttctg ccggtggctc cggttctggc tccagcggtg gcagctctgg tgcgtccggc       60

acgggtactg cgggtggcac tggcagcggt tccggtactg gctctggc                   108


<210> 108
<211> 108
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      polynucleotide

<400> 108
ggtggttctg gcggcggttc tgaaggtggc ggctccgaag gcggcggcag cgagggcggt       60

ggtagcgaag gtggtggctc cgagggtggc ggttccggcg gcggtagc                   108


<210> 109
<211> 108
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      polynucleotide

<400> 109
ggtggttctg gcggcggttc tgaaggtggc ggctccgaag gcggcggcag cgagggcggt       60

ggtagcgaag gtggtggctc cgagggtggc ggttccggcg gcggtagc                   108


<210> 110
<211> 108
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      polynucleotide

<400> 110
ggtggttctg ccggtggctc cggttctggc tccagcggtg gcagctctgg tgcgtccggc       60

acgggtactg cgggtggcac tggcagcggt tccggtactg gctctggc                   108


<210> 111
<211> 45
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide

<400> 111
ggtggaggag gctctggtgg aggcggtagc ggaggcggag ggtcg                       45


<210> 112
<211> 12
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide

<400> 112
ggtggttctg gt                                                           12


<210> 113
<211> 30
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide

<400> 113
ggtgaaaatt tgtattttca atctggtggt                                        30


<210> 114
<211> 18
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide

<400> 114
ggaggttcag gaggcagc                                                     18


<210> 115
<211> 6
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      6xHis tag

<400> 115
His His His His His His 
1               5       


<210> 116
<211> 23
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      peptide

<400> 116
Ala Gly Val Met His Cys Phe Trp Asp Glu Glu Phe Arg Cys Glu Tyr 
1               5                   10                  15      


Val Gly Thr Gly Gly Gly Lys 
            20              


<210> 117
<211> 25
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      primer

<400> 117
cggcgcaact atcggtatca agctg                                             25


<210> 118
<211> 26
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      primer

<400> 118
catgtaccgt aacactgagt ttcgtc                                            26


<210> 119
<211> 24
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      primer

<400> 119
gataaccgat acaattaagg ctcc                                              24


<210> 120
<211> 38
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      polypeptide

<400> 120
Arg Tyr Phe Cys Thr Lys Trp Lys His Gly Trp Cys Glu Glu Val Gly 
1               5                   10                  15      


Thr Gly Gly Gly Arg Tyr Phe Cys Thr Lys Trp Lys His Gly Trp Cys 
            20                  25                  30          


Val Glu Glu Val Gly Thr 
        35              


<210> 121
<211> 21
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      peptide

<400> 121
Arg Tyr Phe Cys Thr Lys Trp Lys His Gly Trp Cys Glu Glu Val Gly 
1               5                   10                  15      


Thr Gly Gly Gly Arg 
            20      


<210> 122
<211> 15
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      peptide

<400> 122
Val Met Thr Cys Trp Trp Asp Gln Gly Phe Glu Cys Ala Lys Leu 
1               5                   10                  15  


<210> 123
<211> 13
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      peptide


<220>
<221> MOD_RES
<222> (3)..(3)
<223> Pen

<220>
<221> MOD_RES
<222> (9)..(9)
<223> Sar

<220>
<221> MOD_RES
<222> (10)..(10)
<223> NMeLeu

<400> 123
Arg Phe Xaa Thr Gly His Phe Gly Xaa Leu Tyr Pro Cys 
1               5                   10              


<210> 124
<211> 17
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      peptide


<220>
<221> MOD_RES
<222> (1)..(1)
<223> Arg or a conservative amino acid substitution of Arg 

<220>
<221> MOD_RES
<222> (3)..(3)
<223> Phe or a conservative amino acid substitution of Phe 

<220>
<221> MOD_RES
<222> (5)..(5)
<223> Thr or a conservative amino acid substitution of Thr 

<220>
<221> MOD_RES
<222> (6)..(6)
<223> Lys or a conservative amino acid substitution of Lys 

<220>
<221> MOD_RES
<222> (8)..(8) 
<223> Lys or a conservative amino acid substitution of Lys

<220>
<221> MOD_RES
<222> (9)..(9) 
<223> His or a conservative amino acid substitution of His

<220>
<221> MOD_RES
<222> (10)..(10) 
<223> Gly or a conservative amino acid substitution of Gly

<220>
<221> MOD_RES
<222> (13)..(14) 
<223> Glu or a conservative amino acid substitution of Glu

<220>
<221> MOD_RES
<222> (16)..(16) 
<223> Gly or a conservative amino acid substitution of Gly 
      or absent

<220>
<221> MOD_RES
<222> (17)..(17) 
<223> Thr or a conservative amino acid substitution of Thr
      or absent

<220> 
<223> see specification as filed for detailed description of
      substitutions and preferred embodiments

<400> 124
Xaa Tyr Xaa Cys Xaa Xaa Trp Xaa Xaa Xaa Trp Cys Xaa Xaa Val Xaa 
1               5                   10                  15      


Xaa 
    



