                               SEQUENCE LISTING

<110> THE BRIGHAM AND WOMEN'S HOSPITAL, INC.
 
<120> METHODS FOR TREATMENT OF CARDIOMYOPATHY

<130> 043214-077971-PCT

<140>
<141>

<150> 61/819,174
<151> 2013-05-03

<160> 2     

<170> PatentIn version 3.5

<210> 1
<211> 926
<212> PRT
<213> Homo sapiens

<400> 1
Met Pro Val Arg Lys Gln Asp Thr Gln Arg Ala Leu His Leu Leu Glu 
1               5                   10                  15      


Glu Tyr Arg Ser Lys Leu Ser Gln Thr Glu Asp Arg Gln Leu Arg Ser 
            20                  25                  30          


Ser Ile Glu Arg Val Ile Asn Ile Phe Gln Ser Asn Leu Phe Gln Ala 
        35                  40                  45              


Leu Ile Asp Ile Gln Glu Phe Tyr Glu Val Thr Leu Leu Asp Asn Pro 
    50                  55                  60                  


Lys Cys Ile Asp Arg Ser Lys Pro Ser Glu Pro Ile Gln Pro Val Asn 
65                  70                  75                  80  


Thr Trp Glu Ile Ser Ser Leu Pro Ser Ser Thr Val Thr Ser Glu Thr 
                85                  90                  95      


Leu Pro Ser Ser Leu Ser Pro Ser Val Glu Lys Tyr Arg Tyr Gln Asp 
            100                 105                 110         


Glu Asp Thr Pro Pro Gln Glu His Ile Ser Pro Gln Ile Thr Asn Glu 
        115                 120                 125             


Val Ile Gly Pro Glu Leu Val His Val Ser Glu Lys Asn Leu Ser Glu 
    130                 135                 140                 


Ile Glu Asn Val His Gly Phe Val Ser His Ser His Ile Ser Pro Ile 
145                 150                 155                 160 


Lys Pro Thr Glu Ala Val Leu Pro Ser Pro Pro Thr Val Pro Val Ile 
                165                 170                 175     


Pro Val Leu Pro Val Pro Ala Glu Asn Thr Val Ile Leu Pro Thr Ile 
            180                 185                 190         


Pro Gln Ala Asn Pro Pro Pro Val Leu Val Asn Thr Asp Ser Leu Glu 
        195                 200                 205             


Thr Pro Thr Tyr Val Asn Gly Thr Asp Ala Asp Tyr Glu Tyr Glu Glu 
    210                 215                 220                 


Ile Thr Leu Glu Arg Gly Asn Ser Gly Leu Gly Phe Ser Ile Ala Gly 
225                 230                 235                 240 


Gly Thr Asp Asn Pro His Ile Gly Asp Asp Ser Ser Ile Phe Ile Thr 
                245                 250                 255     


Lys Ile Ile Thr Gly Gly Ala Ala Ala Gln Asp Gly Arg Leu Arg Val 
            260                 265                 270         


Asn Asp Cys Ile Leu Arg Val Asn Glu Val Asp Val Arg Asp Val Thr 
        275                 280                 285             


His Ser Lys Ala Val Glu Ala Leu Lys Glu Ala Gly Ser Ile Val Arg 
    290                 295                 300                 


Leu Tyr Val Lys Arg Arg Lys Pro Val Ser Glu Lys Ile Met Glu Ile 
305                 310                 315                 320 


Lys Leu Ile Lys Gly Pro Lys Gly Leu Gly Phe Ser Ile Ala Gly Gly 
                325                 330                 335     


Val Gly Asn Gln His Ile Pro Gly Asp Asn Ser Ile Tyr Val Thr Lys 
            340                 345                 350         


Ile Ile Glu Gly Gly Ala Ala His Lys Asp Gly Lys Leu Gln Ile Gly 
        355                 360                 365             


Asp Lys Leu Leu Ala Val Asn Asn Val Cys Leu Glu Glu Val Thr His 
    370                 375                 380                 


Glu Glu Ala Val Thr Ala Leu Lys Asn Thr Ser Asp Phe Val Tyr Leu 
385                 390                 395                 400 


Lys Val Ala Lys Pro Thr Ser Met Tyr Met Asn Asp Gly Tyr Ala Pro 
                405                 410                 415     


Pro Asp Ile Thr Asn Ser Ser Ser Gln Pro Val Asp Asn His Val Ser 
            420                 425                 430         


Pro Ser Ser Phe Leu Gly Gln Thr Pro Ala Ser Pro Ala Arg Tyr Ser 
        435                 440                 445             


Pro Val Ser Lys Ala Val Leu Gly Asp Asp Glu Ile Thr Arg Glu Pro 
    450                 455                 460                 


Arg Lys Val Val Leu His Arg Gly Ser Thr Gly Leu Gly Phe Asn Ile 
465                 470                 475                 480 


Val Gly Gly Glu Asp Gly Glu Gly Ile Phe Ile Ser Phe Ile Leu Ala 
                485                 490                 495     


Gly Gly Pro Ala Asp Leu Ser Gly Glu Leu Arg Lys Gly Asp Arg Ile 
            500                 505                 510         


Ile Ser Val Asn Ser Val Asp Leu Arg Ala Ala Ser His Glu Gln Ala 
        515                 520                 525             


Ala Ala Ala Leu Lys Asn Ala Gly Gln Ala Val Thr Ile Val Ala Gln 
    530                 535                 540                 


Tyr Arg Pro Glu Glu Tyr Ser Arg Phe Glu Ala Lys Ile His Asp Leu 
545                 550                 555                 560 


Arg Glu Gln Met Met Asn Ser Ser Ile Ser Ser Gly Ser Gly Ser Leu 
                565                 570                 575     


Arg Thr Ser Gln Lys Arg Ser Leu Tyr Val Arg Ala Leu Phe Asp Tyr 
            580                 585                 590         


Asp Lys Thr Lys Asp Ser Gly Leu Pro Ser Gln Gly Leu Asn Phe Lys 
        595                 600                 605             


Phe Gly Asp Ile Leu His Val Ile Asn Ala Ser Asp Asp Glu Trp Trp 
    610                 615                 620                 


Gln Ala Arg Gln Val Thr Pro Asp Gly Glu Ser Asp Glu Val Gly Val 
625                 630                 635                 640 


Ile Pro Ser Lys Arg Arg Val Glu Lys Lys Glu Arg Ala Arg Leu Lys 
                645                 650                 655     


Thr Val Lys Phe Asn Ser Lys Thr Arg Asp Lys Gly Gln Ser Phe Asn 
            660                 665                 670         


Asp Lys Arg Lys Lys Asn Leu Phe Ser Arg Lys Phe Pro Phe Tyr Lys 
        675                 680                 685             


Asn Lys Asp Gln Ser Glu Gln Glu Thr Ser Asp Ala Asp Gln His Val 
    690                 695                 700                 


Thr Ser Asn Ala Ser Asp Ser Glu Ser Ser Tyr Arg Gly Gln Glu Glu 
705                 710                 715                 720 


Tyr Val Leu Ser Tyr Glu Pro Val Asn Gln Gln Glu Val Asn Tyr Thr 
                725                 730                 735     


Arg Pro Val Ile Ile Leu Gly Pro Met Lys Asp Arg Ile Asn Asp Asp 
            740                 745                 750         


Leu Ile Ser Glu Phe Pro Asp Lys Phe Gly Ser Cys Val Pro His Thr 
        755                 760                 765             


Thr Arg Pro Lys Arg Asp Tyr Glu Val Asp Gly Arg Asp Tyr His Phe 
    770                 775                 780                 


Val Thr Ser Arg Glu Gln Met Glu Lys Asp Ile Gln Glu His Lys Phe 
785                 790                 795                 800 


Ile Glu Ala Gly Gln Tyr Asn Asn His Leu Tyr Gly Thr Ser Val Gln 
                805                 810                 815     


Ser Val Arg Glu Val Ala Glu Lys Gly Lys His Cys Ile Leu Asp Val 
            820                 825                 830         


Ser Gly Asn Ala Ile Lys Arg Leu Gln Ile Ala Gln Leu Tyr Pro Ile 
        835                 840                 845             


Ser Ile Phe Ile Lys Pro Lys Ser Met Glu Asn Ile Met Glu Met Asn 
    850                 855                 860                 


Lys Arg Leu Thr Glu Glu Gln Ala Arg Lys Thr Phe Glu Arg Ala Met 
865                 870                 875                 880 


Lys Leu Glu Gln Glu Phe Thr Glu His Phe Thr Ala Ile Val Gln Gly 
                885                 890                 895     


Asp Thr Leu Glu Asp Ile Tyr Asn Gln Val Lys Gln Ile Ile Glu Glu 
            900                 905                 910         


Gln Ser Gly Ser Tyr Ile Trp Val Pro Ala Lys Glu Lys Leu 
        915                 920                 925     


<210> 2
<211> 5034
<212> DNA
<213> Homo sapiens

<400> 2
gttggaaacg gcactgctga gtgaggttga ggggtgtctc ggtatgtgcg ccttggatct       60

ggtgtaggcg aggtcacgcc tctcttcaga cagcccgagc cttcccggcc tggcgcgttt      120

agttcggaac tgcgggacgc gccggtgggc tagggcaagg tgtgtgccct cttcctgatt      180

ctggagaaaa atgccggtcc ggaagcaaga tacccagaga gcattgcacc ttttggagga      240

atatcgttca aaactaagcc aaactgaaga cagacagctc agaagttcca tagaacgggt      300

tattaacata tttcagagca acctctttca ggctttaata gatattcaag aattttatga      360

agtgacctta ctggataatc caaaatgtat agatcgttca aagccgtctg aaccaattca      420

acctgtgaat acttgggaga tttccagcct tccaagctct actgtgactt cagagacact      480

gccaagcagc cttagcccta gtgtagagaa atacaggtat caggatgaag atacacctcc      540

tcaagagcat atttccccac aaatcacaaa tgaagtgata ggtccagaat tggttcatgt      600

ctcagagaag aacttatcag agattgagaa tgtccatgga tttgtttctc attctcatat      660

ttcaccaata aagccaacag aagctgttct tccctctcct cccactgtcc ctgtgatccc      720

tgtcctgcca gtccctgctg agaatactgt catcctaccc accataccac aggcaaatcc      780

tcccccagta ctggtcaaca cagatagctt ggaaacacca acttacgtta atggcacaga      840

tgcagattat gaatatgaag aaatcacact tgaaagggga aattcagggc ttggtttcag      900

cattgcagga ggtacggaca acccacacat tggagatgac tcaagtattt tcattaccaa      960

aattatcaca gggggagcag ccgcccaaga tggaagattg cgggtcaatg actgtatatt     1020

acgagtaaat gaagtagatg ttcgtgatgt aacacatagc aaagcagttg aagcgttgaa     1080

agaagcaggg tctattgtac gcttgtatgt aaaaagaagg aaaccagtgt cagaaaaaat     1140

aatggaaata aagctcatta aaggtcctaa aggtcttggg tttagcattg ctggaggtgt     1200

tggaaatcag catattcctg gggataatag catctatgta accaaaataa ttgaaggagg     1260

tgcagcacat aaggatggca aacttcagat tggagataaa cttttagcag tgaataacgt     1320

atgtttagaa gaagttactc atgaagaagc agtaactgcc ttaaagaaca catctgattt     1380

tgtttatttg aaagtggcaa aacccacaag tatgtatatg aatgatggct atgcaccacc     1440

tgatatcacc aactcttctt ctcagcctgt tgataaccat gttagcccat cttccttctt     1500

gggccagaca ccagcatctc cagccagata ctccccagtt tctaaagcag tacttggaga     1560

tgatgaaatt acaagggaac ctagaaaagt tgttcttcat cgtggctcaa cgggccttgg     1620

tttcaacatt gtaggaggag aagatggaga aggaatattt atttccttta tcttagccgg     1680

aggacctgct gatctaagtg gagagctcag aaaaggagat cgtattatat cggtaaacag     1740

tgttgacctc agagctgcta gtcatgagca ggcagcagct gcattgaaaa atgctggcca     1800

ggctgtcaca attgttgcac aatatcgacc tgaagaatac agtcgttttg aagctaaaat     1860

acatgattta cgggagcaga tgatgaatag tagtattagt tcagggtcag gttctcttcg     1920

aactagccag aagcgatccc tctatgtcag agcccttttt gattatgaca agactaaaga     1980

cagtgggctt cccagtcagg gactgaactt caaatttgga gatatcctcc atgttattaa     2040

tgcttctgat gatgaatggt ggcaagccag gcaggttaca ccagatggtg agagcgatga     2100

ggtcggagtg attcccagta aacgcagagt tgagaagaaa gaacgagccc gattaaaaac     2160

agtgaaattc aattctaaaa cgagagataa agggcagtca ttcaatgaca agcgtaaaaa     2220

gaacctcttt tcccgaaaat tccccttcta caagaacaag gaccagagtg agcaggaaac     2280

aagtgatgct gaccagcatg taacttctaa tgccagcgat agtgaaagta gttaccgtgg     2340

tcaagaagaa tacgtcttat cttatgaacc agtgaatcaa caagaagtta attatactcg     2400

accagtgatc atattgggac ctatgaaaga caggataaat gatgacttga tctcagaatt     2460

tcctgacaaa tttggatcct gtgttcctca tacaactaga ccaaaacgag attatgaggt     2520

agatggaaga gattatcatt ttgtgacttc aagagagcag atggaaaaag atatccagga     2580

acataaattc attgaagctg gccagtataa caatcatcta tatggaacaa gtgttcagtc     2640

tgtacgagaa gtagcagaaa agggcaaaca ctgtatcctt gatgtgtctg gaaatgccat     2700

aaagagatta cagattgcac agctttaccc tatctccatt tttattaaac ccaaatccat     2760

ggaaaatatc atggaaatga ataagcgtct aacagaagaa caagccagaa aaacatttga     2820

gagagccatg aaactggaac aggagtttac tgaacatttc acagctattg tacaggggga     2880

tacgctggaa gacatttaca accaagtgaa acagatcata gaagaacaat ctggttctta     2940

catctgggtt ccggcaaaag aaaagctatg aaaactcatg tttctctgtt tctcttttcc     3000

acaattccat tttctttggc atctctttgc cctttcctct ggagtctttc ttgagtactg     3060

atttcatgtt gaattgtatc ccacacatca tggtctgcag cttctttttc acatgtagtg     3120

tctccttcaa gttacatcgt gtgtattatt taatgtcact attggttagt ggccattttt     3180

cagaactgaa gatggaatgg cctgaccagc tattaagaac gtggggagac gcagaaattg     3240

tggtaaaatt ccttaatgtt taagggaaag taactttaag agatttttgg aaaagcttta     3300

tatacattct tttcaaattt cagtacaaat gaaaaagtgg ttttaatcag tgatttagta     3360

gactttgagc aactgtgcac gcttcagttt aatagcatgg tttggccagt gtattactct     3420

caagtccttt tctcaatcaa cttctatcat caaagcaatt gtttcattat agataaataa     3480

ggacattttt taatttaaaa attcatgtct gagttgactt tcataaggga tttcattttt     3540

tcctcaacat tcttaaagcc ttttagtatt tgacggttct tttttcccag gacatttgct     3600

aggaataaca acgtttcaat gtttttaatc tacttgagca acactatcgt gtcttacaaa     3660

agttgttcat atgtaaatga tcatcacatt tcgtgaattg aggccatgtt caggtgctaa     3720

ggaagttcgc cttttacaca gaagattgag aaaatttcct agatataaat acagataaat     3780

cagacgttac agtggtgacg tagtaaccat catggcaatg gaaaggagtc caattcatag     3840

cctaaaactt caaatgtatt cttaggagtc agattttact gaatatttta cccacaatag     3900

ctgcctattt tgttataata aaatatatat aaatatatat ataaaacttt ctttaaactg     3960

taactatggg aattattttc tttacatagt tgcgcacaca cacaaacata tatatatatt     4020

taaaatatat tttgtttctt ttgccaccta ctcctaactt tttgtttggt ttttaaatta     4080

aatattaatt gaatagactt atcttcctta atcatgtgaa ctgaaaatgg gggcatggtg     4140

gtcatgagga ggaaacattt agggaaatta gattataagt aaaagtgtgg gcatattctc     4200

ctcttttcta caaaggtttt caaatggttc ctgaggtttt ttgttgttgt ccgtgttgtt     4260

actgttgttc ttgtcatcag gtttgatttt ggtccttgcc ctttccttct agttctcctt     4320

ttattaatag gaaggcaggc aaaagcccca tttatgtgtg tgttttcccc tcagacagct     4380

ttcatccact gctctgcact agaattgcac aaatcttcat ggtgagcaat tttaagaaat     4440

gttagtgaaa ggtagaaatt atttcacaaa tcagtttctc tggtccttca tattaataat     4500

aatatttggc ttcccattgc tctttggagt tgtttattaa atatgtgttt ttgacaacct     4560

cctcattagt ttcttaaatg agtactggtt tgtaaagaat tatcaacatt atccattcca     4620

tttatgaaga agaggagaac agctaataaa ctgtattgta aaatccatat gttaagtgtg     4680

tcttgaattt tgaaagaaaa aatatatttt gcaagctaac attttcttga aacaatttga     4740

ggcatcatgt aacttataac cgaatccaag agccgttagg cagcagagtg tgttaccaca     4800

ttgaaataca cagtgctgct gttagactaa atgtcgtagg ttgttaacca catagaaaca     4860

cactagtatg aagaaaactg ttgtaaaatc tcaagagctt cagaaactgc cttacaagac     4920

cgcagcataa gctattttga agtatttacc aaatagtcac atgttgtaaa atatcaagtg     4980

gttataaaag gatgccattt atatattaaa atttacataa cattgttttc tgga           5034


