                               SEQUENCE LISTING

<110> THE GENERAL HOSPITAL CORPORATION
 
<120> USING RNA-GUIDED FOKI NUCLEASES (RFNS) TO INCREASE SPECIFICITY 
      FOR RNA-GUIDED GENOME EDITING

<130> 00786-0895WO2

<140> PCT/US2014/035162
<141> 2014-04-23

<150> 61/921,007
<151> 2013-12-26

<150> 61/838,148
<151> 2013-06-21

<150> 61/838,178
<151> 2013-06-21

<150> PCT/US2014/028630
<151> 2014-03-14

<160> 466   

<170> PatentIn version 3.5

<210> 1
<211> 23
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      binding site oligonucleotide

<400> 1
gggcacgggc agcttgccgg tgg                                               23


<210> 2
<211> 23
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      binding site oligonucleotide

<400> 2
gatgccgttc ttctgcttgt cgg                                               23


<210> 3
<211> 23
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      binding site oligonucleotide

<400> 3
ggtggtgcag atgaacttca ggg                                               23


<210> 4
<211> 583
<212> PRT
<213> Planomicrobium okeanokoites

<400> 4
Met Phe Leu Ser Met Val Ser Lys Ile Arg Thr Phe Gly Trp Val Gln 
1               5                   10                  15      


Asn Pro Gly Lys Phe Glu Asn Leu Lys Arg Val Val Gln Val Phe Asp 
            20                  25                  30          


Arg Asn Ser Lys Val His Asn Glu Val Lys Asn Ile Lys Ile Pro Thr 
        35                  40                  45              


Leu Val Lys Glu Ser Lys Ile Gln Lys Glu Leu Val Ala Ile Met Asn 
    50                  55                  60                  


Gln His Asp Leu Ile Tyr Thr Tyr Lys Glu Leu Val Gly Thr Gly Thr 
65                  70                  75                  80  


Ser Ile Arg Ser Glu Ala Pro Cys Asp Ala Ile Ile Gln Ala Thr Ile 
                85                  90                  95      


Ala Asp Gln Gly Asn Lys Lys Gly Tyr Ile Asp Asn Trp Ser Ser Asp 
            100                 105                 110         


Gly Phe Leu Arg Trp Ala His Ala Leu Gly Phe Ile Glu Tyr Ile Asn 
        115                 120                 125             


Lys Ser Asp Ser Phe Val Ile Thr Asp Val Gly Leu Ala Tyr Ser Lys 
    130                 135                 140                 


Ser Ala Asp Gly Ser Ala Ile Glu Lys Glu Ile Leu Ile Glu Ala Ile 
145                 150                 155                 160 


Ser Ser Tyr Pro Pro Ala Ile Arg Ile Leu Thr Leu Leu Glu Asp Gly 
                165                 170                 175     


Gln His Leu Thr Lys Phe Asp Leu Gly Lys Asn Leu Gly Phe Ser Gly 
            180                 185                 190         


Glu Ser Gly Phe Thr Ser Leu Pro Glu Gly Ile Leu Leu Asp Thr Leu 
        195                 200                 205             


Ala Asn Ala Met Pro Lys Asp Lys Gly Glu Ile Arg Asn Asn Trp Glu 
    210                 215                 220                 


Gly Ser Ser Asp Lys Tyr Ala Arg Met Ile Gly Gly Trp Leu Asp Lys 
225                 230                 235                 240 


Leu Gly Leu Val Lys Gln Gly Lys Lys Glu Phe Ile Ile Pro Thr Leu 
                245                 250                 255     


Gly Lys Pro Asp Asn Lys Glu Phe Ile Ser His Ala Phe Lys Ile Thr 
            260                 265                 270         


Gly Glu Gly Leu Lys Val Leu Arg Arg Ala Lys Gly Ser Thr Lys Phe 
        275                 280                 285             


Thr Arg Val Pro Lys Arg Val Tyr Trp Glu Met Leu Ala Thr Asn Leu 
    290                 295                 300                 


Thr Asp Lys Glu Tyr Val Arg Thr Arg Arg Ala Leu Ile Leu Glu Ile 
305                 310                 315                 320 


Leu Ile Lys Ala Gly Ser Leu Lys Ile Glu Gln Ile Gln Asp Asn Leu 
                325                 330                 335     


Lys Lys Leu Gly Phe Asp Glu Val Ile Glu Thr Ile Glu Asn Asp Ile 
            340                 345                 350         


Lys Gly Leu Ile Asn Thr Gly Ile Phe Ile Glu Ile Lys Gly Arg Phe 
        355                 360                 365             


Tyr Gln Leu Lys Asp His Ile Leu Gln Phe Val Ile Pro Asn Arg Gly 
    370                 375                 380                 


Val Thr Lys Gln Leu Val Lys Ser Glu Leu Glu Glu Lys Lys Ser Glu 
385                 390                 395                 400 


Leu Arg His Lys Leu Lys Tyr Val Pro His Glu Tyr Ile Glu Leu Ile 
                405                 410                 415     


Glu Ile Ala Arg Asn Ser Thr Gln Asp Arg Ile Leu Glu Met Lys Val 
            420                 425                 430         


Met Glu Phe Phe Met Lys Val Tyr Gly Tyr Arg Gly Lys His Leu Gly 
        435                 440                 445             


Gly Ser Arg Lys Pro Asp Gly Ala Ile Tyr Thr Val Gly Ser Pro Ile 
    450                 455                 460                 


Asp Tyr Gly Val Ile Val Asp Thr Lys Ala Tyr Ser Gly Gly Tyr Asn 
465                 470                 475                 480 


Leu Pro Ile Gly Gln Ala Asp Glu Met Gln Arg Tyr Val Glu Glu Asn 
                485                 490                 495     


Gln Thr Arg Asn Lys His Ile Asn Pro Asn Glu Trp Trp Lys Val Tyr 
            500                 505                 510         


Pro Ser Ser Val Thr Glu Phe Lys Phe Leu Phe Val Ser Gly His Phe 
        515                 520                 525             


Lys Gly Asn Tyr Lys Ala Gln Leu Thr Arg Leu Asn His Ile Thr Asn 
    530                 535                 540                 


Cys Asn Gly Ala Val Leu Ser Val Glu Glu Leu Leu Ile Gly Gly Glu 
545                 550                 555                 560 


Met Ile Lys Ala Gly Thr Leu Thr Leu Glu Glu Val Arg Arg Lys Phe 
                565                 570                 575     


Asn Asn Gly Glu Ile Asn Phe 
            580             


<210> 5
<211> 1368
<212> PRT
<213> Streptococcus pyogenes

<400> 5
Met Asp Lys Lys Tyr Ser Ile Gly Leu Ala Ile Gly Thr Asn Ser Val 
1               5                   10                  15      


Gly Trp Ala Val Ile Thr Asp Glu Tyr Lys Val Pro Ser Lys Lys Phe 
            20                  25                  30          


Lys Val Leu Gly Asn Thr Asp Arg His Ser Ile Lys Lys Asn Leu Ile 
        35                  40                  45              


Gly Ala Leu Leu Phe Asp Ser Gly Glu Thr Ala Glu Ala Thr Arg Leu 
    50                  55                  60                  


Lys Arg Thr Ala Arg Arg Arg Tyr Thr Arg Arg Lys Asn Arg Ile Cys 
65                  70                  75                  80  


Tyr Leu Gln Glu Ile Phe Ser Asn Glu Met Ala Lys Val Asp Asp Ser 
                85                  90                  95      


Phe Phe His Arg Leu Glu Glu Ser Phe Leu Val Glu Glu Asp Lys Lys 
            100                 105                 110         


His Glu Arg His Pro Ile Phe Gly Asn Ile Val Asp Glu Val Ala Tyr 
        115                 120                 125             


His Glu Lys Tyr Pro Thr Ile Tyr His Leu Arg Lys Lys Leu Val Asp 
    130                 135                 140                 


Ser Thr Asp Lys Ala Asp Leu Arg Leu Ile Tyr Leu Ala Leu Ala His 
145                 150                 155                 160 


Met Ile Lys Phe Arg Gly His Phe Leu Ile Glu Gly Asp Leu Asn Pro 
                165                 170                 175     


Asp Asn Ser Asp Val Asp Lys Leu Phe Ile Gln Leu Val Gln Thr Tyr 
            180                 185                 190         


Asn Gln Leu Phe Glu Glu Asn Pro Ile Asn Ala Ser Gly Val Asp Ala 
        195                 200                 205             


Lys Ala Ile Leu Ser Ala Arg Leu Ser Lys Ser Arg Arg Leu Glu Asn 
    210                 215                 220                 


Leu Ile Ala Gln Leu Pro Gly Glu Lys Lys Asn Gly Leu Phe Gly Asn 
225                 230                 235                 240 


Leu Ile Ala Leu Ser Leu Gly Leu Thr Pro Asn Phe Lys Ser Asn Phe 
                245                 250                 255     


Asp Leu Ala Glu Asp Ala Lys Leu Gln Leu Ser Lys Asp Thr Tyr Asp 
            260                 265                 270         


Asp Asp Leu Asp Asn Leu Leu Ala Gln Ile Gly Asp Gln Tyr Ala Asp 
        275                 280                 285             


Leu Phe Leu Ala Ala Lys Asn Leu Ser Asp Ala Ile Leu Leu Ser Asp 
    290                 295                 300                 


Ile Leu Arg Val Asn Thr Glu Ile Thr Lys Ala Pro Leu Ser Ala Ser 
305                 310                 315                 320 


Met Ile Lys Arg Tyr Asp Glu His His Gln Asp Leu Thr Leu Leu Lys 
                325                 330                 335     


Ala Leu Val Arg Gln Gln Leu Pro Glu Lys Tyr Lys Glu Ile Phe Phe 
            340                 345                 350         


Asp Gln Ser Lys Asn Gly Tyr Ala Gly Tyr Ile Asp Gly Gly Ala Ser 
        355                 360                 365             


Gln Glu Glu Phe Tyr Lys Phe Ile Lys Pro Ile Leu Glu Lys Met Asp 
    370                 375                 380                 


Gly Thr Glu Glu Leu Leu Val Lys Leu Asn Arg Glu Asp Leu Leu Arg 
385                 390                 395                 400 


Lys Gln Arg Thr Phe Asp Asn Gly Ser Ile Pro His Gln Ile His Leu 
                405                 410                 415     


Gly Glu Leu His Ala Ile Leu Arg Arg Gln Glu Asp Phe Tyr Pro Phe 
            420                 425                 430         


Leu Lys Asp Asn Arg Glu Lys Ile Glu Lys Ile Leu Thr Phe Arg Ile 
        435                 440                 445             


Pro Tyr Tyr Val Gly Pro Leu Ala Arg Gly Asn Ser Arg Phe Ala Trp 
    450                 455                 460                 


Met Thr Arg Lys Ser Glu Glu Thr Ile Thr Pro Trp Asn Phe Glu Glu 
465                 470                 475                 480 


Val Val Asp Lys Gly Ala Ser Ala Gln Ser Phe Ile Glu Arg Met Thr 
                485                 490                 495     


Asn Phe Asp Lys Asn Leu Pro Asn Glu Lys Val Leu Pro Lys His Ser 
            500                 505                 510         


Leu Leu Tyr Glu Tyr Phe Thr Val Tyr Asn Glu Leu Thr Lys Val Lys 
        515                 520                 525             


Tyr Val Thr Glu Gly Met Arg Lys Pro Ala Phe Leu Ser Gly Glu Gln 
    530                 535                 540                 


Lys Lys Ala Ile Val Asp Leu Leu Phe Lys Thr Asn Arg Lys Val Thr 
545                 550                 555                 560 


Val Lys Gln Leu Lys Glu Asp Tyr Phe Lys Lys Ile Glu Cys Phe Asp 
                565                 570                 575     


Ser Val Glu Ile Ser Gly Val Glu Asp Arg Phe Asn Ala Ser Leu Gly 
            580                 585                 590         


Thr Tyr His Asp Leu Leu Lys Ile Ile Lys Asp Lys Asp Phe Leu Asp 
        595                 600                 605             


Asn Glu Glu Asn Glu Asp Ile Leu Glu Asp Ile Val Leu Thr Leu Thr 
    610                 615                 620                 


Leu Phe Glu Asp Arg Glu Met Ile Glu Glu Arg Leu Lys Thr Tyr Ala 
625                 630                 635                 640 


His Leu Phe Asp Asp Lys Val Met Lys Gln Leu Lys Arg Arg Arg Tyr 
                645                 650                 655     


Thr Gly Trp Gly Arg Leu Ser Arg Lys Leu Ile Asn Gly Ile Arg Asp 
            660                 665                 670         


Lys Gln Ser Gly Lys Thr Ile Leu Asp Phe Leu Lys Ser Asp Gly Phe 
        675                 680                 685             


Ala Asn Arg Asn Phe Met Gln Leu Ile His Asp Asp Ser Leu Thr Phe 
    690                 695                 700                 


Lys Glu Asp Ile Gln Lys Ala Gln Val Ser Gly Gln Gly Asp Ser Leu 
705                 710                 715                 720 


His Glu His Ile Ala Asn Leu Ala Gly Ser Pro Ala Ile Lys Lys Gly 
                725                 730                 735     


Ile Leu Gln Thr Val Lys Val Val Asp Glu Leu Val Lys Val Met Gly 
            740                 745                 750         


Arg His Lys Pro Glu Asn Ile Val Ile Glu Met Ala Arg Glu Asn Gln 
        755                 760                 765             


Thr Thr Gln Lys Gly Gln Lys Asn Ser Arg Glu Arg Met Lys Arg Ile 
    770                 775                 780                 


Glu Glu Gly Ile Lys Glu Leu Gly Ser Gln Ile Leu Lys Glu His Pro 
785                 790                 795                 800 


Val Glu Asn Thr Gln Leu Gln Asn Glu Lys Leu Tyr Leu Tyr Tyr Leu 
                805                 810                 815     


Gln Asn Gly Arg Asp Met Tyr Val Asp Gln Glu Leu Asp Ile Asn Arg 
            820                 825                 830         


Leu Ser Asp Tyr Asp Val Asp Ala Ile Val Pro Gln Ser Phe Leu Lys 
        835                 840                 845             


Asp Asp Ser Ile Asp Asn Lys Val Leu Thr Arg Ser Asp Lys Asn Arg 
    850                 855                 860                 


Gly Lys Ser Asp Asn Val Pro Ser Glu Glu Val Val Lys Lys Met Lys 
865                 870                 875                 880 


Asn Tyr Trp Arg Gln Leu Leu Asn Ala Lys Leu Ile Thr Gln Arg Lys 
                885                 890                 895     


Phe Asp Asn Leu Thr Lys Ala Glu Arg Gly Gly Leu Ser Glu Leu Asp 
            900                 905                 910         


Lys Ala Gly Phe Ile Lys Arg Gln Leu Val Glu Thr Arg Gln Ile Thr 
        915                 920                 925             


Lys His Val Ala Gln Ile Leu Asp Ser Arg Met Asn Thr Lys Tyr Asp 
    930                 935                 940                 


Glu Asn Asp Lys Leu Ile Arg Glu Val Lys Val Ile Thr Leu Lys Ser 
945                 950                 955                 960 


Lys Leu Val Ser Asp Phe Arg Lys Asp Phe Gln Phe Tyr Lys Val Arg 
                965                 970                 975     


Glu Ile Asn Asn Tyr His His Ala His Asp Ala Tyr Leu Asn Ala Val 
            980                 985                 990         


Val Gly Thr Ala Leu Ile Lys Lys  Tyr Pro Lys Leu Glu  Ser Glu Phe 
        995                 1000                 1005             


Val Tyr  Gly Asp Tyr Lys Val  Tyr Asp Val Arg Lys  Met Ile Ala 
    1010                 1015                 1020             


Lys Ser  Glu Gln Glu Ile Gly  Lys Ala Thr Ala Lys  Tyr Phe Phe 
    1025                 1030                 1035             


Tyr Ser  Asn Ile Met Asn Phe  Phe Lys Thr Glu Ile  Thr Leu Ala 
    1040                 1045                 1050             


Asn Gly  Glu Ile Arg Lys Arg  Pro Leu Ile Glu Thr  Asn Gly Glu 
    1055                 1060                 1065             


Thr Gly  Glu Ile Val Trp Asp  Lys Gly Arg Asp Phe  Ala Thr Val 
    1070                 1075                 1080             


Arg Lys  Val Leu Ser Met Pro  Gln Val Asn Ile Val  Lys Lys Thr 
    1085                 1090                 1095             


Glu Val  Gln Thr Gly Gly Phe  Ser Lys Glu Ser Ile  Leu Pro Lys 
    1100                 1105                 1110             


Arg Asn  Ser Asp Lys Leu Ile  Ala Arg Lys Lys Asp  Trp Asp Pro 
    1115                 1120                 1125             


Lys Lys  Tyr Gly Gly Phe Asp  Ser Pro Thr Val Ala  Tyr Ser Val 
    1130                 1135                 1140             


Leu Val  Val Ala Lys Val Glu  Lys Gly Lys Ser Lys  Lys Leu Lys 
    1145                 1150                 1155             


Ser Val  Lys Glu Leu Leu Gly  Ile Thr Ile Met Glu  Arg Ser Ser 
    1160                 1165                 1170             


Phe Glu  Lys Asn Pro Ile Asp  Phe Leu Glu Ala Lys  Gly Tyr Lys 
    1175                 1180                 1185             


Glu Val  Lys Lys Asp Leu Ile  Ile Lys Leu Pro Lys  Tyr Ser Leu 
    1190                 1195                 1200             


Phe Glu  Leu Glu Asn Gly Arg  Lys Arg Met Leu Ala  Ser Ala Gly 
    1205                 1210                 1215             


Glu Leu  Gln Lys Gly Asn Glu  Leu Ala Leu Pro Ser  Lys Tyr Val 
    1220                 1225                 1230             


Asn Phe  Leu Tyr Leu Ala Ser  His Tyr Glu Lys Leu  Lys Gly Ser 
    1235                 1240                 1245             


Pro Glu  Asp Asn Glu Gln Lys  Gln Leu Phe Val Glu  Gln His Lys 
    1250                 1255                 1260             


His Tyr  Leu Asp Glu Ile Ile  Glu Gln Ile Ser Glu  Phe Ser Lys 
    1265                 1270                 1275             


Arg Val  Ile Leu Ala Asp Ala  Asn Leu Asp Lys Val  Leu Ser Ala 
    1280                 1285                 1290             


Tyr Asn  Lys His Arg Asp Lys  Pro Ile Arg Glu Gln  Ala Glu Asn 
    1295                 1300                 1305             


Ile Ile  His Leu Phe Thr Leu  Thr Asn Leu Gly Ala  Pro Ala Ala 
    1310                 1315                 1320             


Phe Lys  Tyr Phe Asp Thr Thr  Ile Asp Arg Lys Arg  Tyr Thr Ser 
    1325                 1330                 1335             


Thr Lys  Glu Val Leu Asp Ala  Thr Leu Ile His Gln  Ser Ile Thr 
    1340                 1345                 1350             


Gly Leu  Tyr Glu Thr Arg Ile  Asp Leu Ser Gln Leu  Gly Gly Asp 
    1355                 1360                 1365             


<210> 6
<211> 262
<212> RNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      guide RNA polynucleotide


<220>
<221> modified_base
<222> (1)..(20)
<223> a, c, u, g, unknown or other and this region may encompass
      17-20 nucleotides

<220>
<221> modified_base
<222> (63)..(262)
<223> a, c, u, g, unknown or other and this region may encompass
      0-200 nucleotides

<400> 6
nnnnnnnnnn nnnnnnnnnn guuuuagagc uagaaauagc aaguuaaaau aaggcuaguc       60

cgnnnnnnnn nnnnnnnnnn nnnnnnnnnn nnnnnnnnnn nnnnnnnnnn nnnnnnnnnn      120

nnnnnnnnnn nnnnnnnnnn nnnnnnnnnn nnnnnnnnnn nnnnnnnnnn nnnnnnnnnn      180

nnnnnnnnnn nnnnnnnnnn nnnnnnnnnn nnnnnnnnnn nnnnnnnnnn nnnnnnnnnn      240

nnnnnnnnnn nnnnnnnnnn nn                                               262


<210> 7
<211> 275
<212> RNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      guide RNA polynucleotide


<220>
<221> modified_base
<222> (1)..(20)
<223> a, c, u, g, unknown or other and this region may encompass
      17-20 nucleotides

<220>
<221> modified_base
<222> (76)..(275)
<223> a, c, u, g, unknown or other and this region may encompass
      0-200 nucleotides

<400> 7
nnnnnnnnnn nnnnnnnnnn guuuuagagc uaugcugaaa agcauagcaa guuaaaauaa       60

ggcuaguccg uuaucnnnnn nnnnnnnnnn nnnnnnnnnn nnnnnnnnnn nnnnnnnnnn      120

nnnnnnnnnn nnnnnnnnnn nnnnnnnnnn nnnnnnnnnn nnnnnnnnnn nnnnnnnnnn      180

nnnnnnnnnn nnnnnnnnnn nnnnnnnnnn nnnnnnnnnn nnnnnnnnnn nnnnnnnnnn      240

nnnnnnnnnn nnnnnnnnnn nnnnnnnnnn nnnnn                                 275


<210> 8
<211> 287
<212> RNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      guide RNA polynucleotide


<220>
<221> modified_base
<222> (1)..(20)
<223> a, c, u, g, unknown or other and this region may encompass
      17-20 nucleotides

<220>
<221> modified_base
<222> (88)..(287)
<223> a, c, u, g, unknown or other and this region may encompass
      0-200 nucleotides

<400> 8
nnnnnnnnnn nnnnnnnnnn guuuuagagc uaugcuguuu uggaaacaaa acagcauagc       60

aaguuaaaau aaggcuaguc cguuaucnnn nnnnnnnnnn nnnnnnnnnn nnnnnnnnnn      120

nnnnnnnnnn nnnnnnnnnn nnnnnnnnnn nnnnnnnnnn nnnnnnnnnn nnnnnnnnnn      180

nnnnnnnnnn nnnnnnnnnn nnnnnnnnnn nnnnnnnnnn nnnnnnnnnn nnnnnnnnnn      240

nnnnnnnnnn nnnnnnnnnn nnnnnnnnnn nnnnnnnnnn nnnnnnn                    287


<210> 9
<211> 296
<212> RNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      guide RNA polynucleotide


<220>
<221> modified_base
<222> (1)..(20)
<223> a, c, u, g, unknown or other and this region may encompass
      17-20 nucleotides

<220>
<221> modified_base
<222> (97)..(296)
<223> a, c, u, g, unknown or other and this region may encompass
      0-200 nucleotides

<400> 9
nnnnnnnnnn nnnnnnnnnn guuuuagagc uagaaauagc aaguuaaaau aaggcuaguc       60

cguuaucaac uugaaaaagu ggcaccgagu cggugcnnnn nnnnnnnnnn nnnnnnnnnn      120

nnnnnnnnnn nnnnnnnnnn nnnnnnnnnn nnnnnnnnnn nnnnnnnnnn nnnnnnnnnn      180

nnnnnnnnnn nnnnnnnnnn nnnnnnnnnn nnnnnnnnnn nnnnnnnnnn nnnnnnnnnn      240

nnnnnnnnnn nnnnnnnnnn nnnnnnnnnn nnnnnnnnnn nnnnnnnnnn nnnnnn          296


<210> 10
<211> 96
<212> RNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      guide RNA oligonucleotide


<220>
<221> modified_base
<222> (1)..(20)
<223> a, c, u, g, unknown or other and this region may encompass
      17-20 nucleotides

<400> 10
nnnnnnnnnn nnnnnnnnnn guuuaagagc uagaaauagc aaguuuaaau aaggcuaguc       60

cguuaucaac uugaaaaagu ggcaccgagu cggugc                                 96


<210> 11
<211> 106
<212> RNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      guide RNA polynucleotide


<220>
<221> modified_base
<222> (1)..(20)
<223> a, c, u, g, unknown or other and this region may encompass
      17-20 nucleotides

<400> 11
nnnnnnnnnn nnnnnnnnnn guuuuagagc uaugcuggaa acagcauagc aaguuuaaau       60

aaggcuaguc cguuaucaac uugaaaaagu ggcaccgagu cggugc                     106


<210> 12
<211> 106
<212> RNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      guide RNA polynucleotide


<220>
<221> modified_base
<222> (1)..(20)
<223> a, c, u, g, unknown or other and this region may encompass
      17-20 nucleotides

<400> 12
nnnnnnnnnn nnnnnnnnnn guuuaagagc uaugcuggaa acagcauagc aaguuuaaau       60

aaggcuaguc cguuaucaac uugaaaaagu ggcaccgagu cggugc                     106


<210> 13
<211> 32
<212> RNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      tracrRNA oligonucleotide 


<220>
<221> modified_base
<222> (1)..(20)
<223> a, c, u, g, unknown or other and this region may encompass
      17-20 nucleotides

<400> 13
nnnnnnnnnn nnnnnnnnnn guuuuagagc ua                                     32


<210> 14
<211> 42
<212> RNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      tracrRNA oligonucleotide 


<220>
<221> modified_base
<222> (1)..(20)
<223> a, c, u, g, unknown or other and this region may encompass
      17-20 nucleotides

<400> 14
nnnnnnnnnn nnnnnnnnnn guuuuagagc uaugcuguuu ug                          42


<210> 15
<211> 36
<212> RNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      tracrRNA oligonucleotide 


<220>
<221> modified_base
<222> (1)..(20)
<223> a, c, u, g, unknown or other and this region may encompass
      17-20 nucleotides

<400> 15
nnnnnnnnnn nnnnnnnnnn guuuuagagc uaugcu                                 36


<210> 16
<211> 79
<212> RNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      tracrRNA oligonucleotide 

<400> 16
ggaaccauuc aaaacagcau agcaaguuaa aauaaggcua guccguuauc aacuugaaaa       60

aguggcaccg agucggugc                                                    79


<210> 17
<211> 60
<212> RNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      tracrRNA oligonucleotide 

<400> 17
uagcaaguua aaauaaggcu aguccguuau caacuugaaa aaguggcacc gagucggugc       60


<210> 18
<211> 64
<212> RNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      tracrRNA oligonucleotide 

<400> 18
agcauagcaa guuaaaauaa ggcuaguccg uuaucaacuu gaaaaagugg caccgagucg       60

gugc                                                                    64


<210> 19
<211> 16
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      primer

<400> 19
gtaaaacgac ggccag                                                       16


<210> 20
<211> 28
<212> RNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      Csy4 RNA binding site oligonucleotide

<400> 20
guucacugcc guauaggcag cuaagaaa                                          28


<210> 21
<211> 252
<212> RNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      multiplex guide RNA polynucleotide


<220>
<221> modified_base
<222> (21)..(40)
<223> a, c, u, g, unknown or other

<220>
<221> modified_base
<222> (137)..(156)
<223> a, c, u, g, unknown or other

<400> 21
guucacugcc guauaggcag nnnnnnnnnn nnnnnnnnnn guuuuagagc uagaaauagc       60

aaguuaaaau aaggcuaguc cguuaucaac uugaaaaagu ggcaccgagu cggugcguuc      120

acugccguau aggcagnnnn nnnnnnnnnn nnnnnnguuu uagagcuaga aauagcaagu      180

uaaaauaagg cuaguccguu aucaacuuga aaaaguggca ccgagucggu gcguucacug      240

ccguauaggc ag                                                          252


<210> 22
<211> 4
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      linker peptide

<400> 22
Gly Gly Gly Ser 
1               


<210> 23
<211> 5
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      linker peptide

<400> 23
Gly Gly Gly Gly Ser 
1               5   


<210> 24
<211> 1602
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      FokI-dCas9 polypeptide

<400> 24
Met Gln Leu Val Lys Ser Glu Leu Glu Glu Lys Lys Ser Glu Leu Arg 
1               5                   10                  15      


His Lys Leu Lys Tyr Val Pro His Glu Tyr Ile Glu Leu Ile Glu Ile 
            20                  25                  30          


Ala Arg Asn Ser Thr Gln Asp Arg Ile Leu Glu Met Lys Val Met Glu 
        35                  40                  45              


Phe Phe Met Lys Val Tyr Gly Tyr Arg Gly Lys His Leu Gly Gly Ser 
    50                  55                  60                  


Arg Lys Pro Asp Gly Ala Ile Tyr Thr Val Gly Ser Pro Ile Asp Tyr 
65                  70                  75                  80  


Gly Val Ile Val Asp Thr Lys Ala Tyr Ser Gly Gly Tyr Asn Leu Pro 
                85                  90                  95      


Ile Gly Gln Ala Asp Glu Met Gln Arg Tyr Val Glu Glu Asn Gln Thr 
            100                 105                 110         


Arg Asn Lys His Ile Asn Pro Asn Glu Trp Trp Lys Val Tyr Pro Ser 
        115                 120                 125             


Ser Val Thr Glu Phe Lys Phe Leu Phe Val Ser Gly His Phe Lys Gly 
    130                 135                 140                 


Asn Tyr Lys Ala Gln Leu Thr Arg Leu Asn His Ile Thr Asn Cys Asn 
145                 150                 155                 160 


Gly Ala Val Leu Ser Val Glu Glu Leu Leu Ile Gly Gly Glu Met Ile 
                165                 170                 175     


Lys Ala Gly Thr Leu Thr Leu Glu Glu Val Arg Arg Lys Phe Asn Asn 
            180                 185                 190         


Gly Glu Ile Asn Phe Gly Gly Gly Gly Ser Asp Lys Lys Tyr Ser Ile 
        195                 200                 205             


Gly Leu Ala Ile Gly Thr Asn Ser Val Gly Trp Ala Val Ile Thr Asp 
    210                 215                 220                 


Glu Tyr Lys Val Pro Ser Lys Lys Phe Lys Val Leu Gly Asn Thr Asp 
225                 230                 235                 240 


Arg His Ser Ile Lys Lys Asn Leu Ile Gly Ala Leu Leu Phe Asp Ser 
                245                 250                 255     


Gly Glu Thr Ala Glu Ala Thr Arg Leu Lys Arg Thr Ala Arg Arg Arg 
            260                 265                 270         


Tyr Thr Arg Arg Lys Asn Arg Ile Cys Tyr Leu Gln Glu Ile Phe Ser 
        275                 280                 285             


Asn Glu Met Ala Lys Val Asp Asp Ser Phe Phe His Arg Leu Glu Glu 
    290                 295                 300                 


Ser Phe Leu Val Glu Glu Asp Lys Lys His Glu Arg His Pro Ile Phe 
305                 310                 315                 320 


Gly Asn Ile Val Asp Glu Val Ala Tyr His Glu Lys Tyr Pro Thr Ile 
                325                 330                 335     


Tyr His Leu Arg Lys Lys Leu Val Asp Ser Thr Asp Lys Ala Asp Leu 
            340                 345                 350         


Arg Leu Ile Tyr Leu Ala Leu Ala His Met Ile Lys Phe Arg Gly His 
        355                 360                 365             


Phe Leu Ile Glu Gly Asp Leu Asn Pro Asp Asn Ser Asp Val Asp Lys 
    370                 375                 380                 


Leu Phe Ile Gln Leu Val Gln Thr Tyr Asn Gln Leu Phe Glu Glu Asn 
385                 390                 395                 400 


Pro Ile Asn Ala Ser Gly Val Asp Ala Lys Ala Ile Leu Ser Ala Arg 
                405                 410                 415     


Leu Ser Lys Ser Arg Arg Leu Glu Asn Leu Ile Ala Gln Leu Pro Gly 
            420                 425                 430         


Glu Lys Lys Asn Gly Leu Phe Gly Asn Leu Ile Ala Leu Ser Leu Gly 
        435                 440                 445             


Leu Thr Pro Asn Phe Lys Ser Asn Phe Asp Leu Ala Glu Asp Ala Lys 
    450                 455                 460                 


Leu Gln Leu Ser Lys Asp Thr Tyr Asp Asp Asp Leu Asp Asn Leu Leu 
465                 470                 475                 480 


Ala Gln Ile Gly Asp Gln Tyr Ala Asp Leu Phe Leu Ala Ala Lys Asn 
                485                 490                 495     


Leu Ser Asp Ala Ile Leu Leu Ser Asp Ile Leu Arg Val Asn Thr Glu 
            500                 505                 510         


Ile Thr Lys Ala Pro Leu Ser Ala Ser Met Ile Lys Arg Tyr Asp Glu 
        515                 520                 525             


His His Gln Asp Leu Thr Leu Leu Lys Ala Leu Val Arg Gln Gln Leu 
    530                 535                 540                 


Pro Glu Lys Tyr Lys Glu Ile Phe Phe Asp Gln Ser Lys Asn Gly Tyr 
545                 550                 555                 560 


Ala Gly Tyr Ile Asp Gly Gly Ala Ser Gln Glu Glu Phe Tyr Lys Phe 
                565                 570                 575     


Ile Lys Pro Ile Leu Glu Lys Met Asp Gly Thr Glu Glu Leu Leu Val 
            580                 585                 590         


Lys Leu Asn Arg Glu Asp Leu Leu Arg Lys Gln Arg Thr Phe Asp Asn 
        595                 600                 605             


Gly Ser Ile Pro His Gln Ile His Leu Gly Glu Leu His Ala Ile Leu 
    610                 615                 620                 


Arg Arg Gln Glu Asp Phe Tyr Pro Phe Leu Lys Asp Asn Arg Glu Lys 
625                 630                 635                 640 


Ile Glu Lys Ile Leu Thr Phe Arg Ile Pro Tyr Tyr Val Gly Pro Leu 
                645                 650                 655     


Ala Arg Gly Asn Ser Arg Phe Ala Trp Met Thr Arg Lys Ser Glu Glu 
            660                 665                 670         


Thr Ile Thr Pro Trp Asn Phe Glu Glu Val Val Asp Lys Gly Ala Ser 
        675                 680                 685             


Ala Gln Ser Phe Ile Glu Arg Met Thr Asn Phe Asp Lys Asn Leu Pro 
    690                 695                 700                 


Asn Glu Lys Val Leu Pro Lys His Ser Leu Leu Tyr Glu Tyr Phe Thr 
705                 710                 715                 720 


Val Tyr Asn Glu Leu Thr Lys Val Lys Tyr Val Thr Glu Gly Met Arg 
                725                 730                 735     


Lys Pro Ala Phe Leu Ser Gly Glu Gln Lys Lys Ala Ile Val Asp Leu 
            740                 745                 750         


Leu Phe Lys Thr Asn Arg Lys Val Thr Val Lys Gln Leu Lys Glu Asp 
        755                 760                 765             


Tyr Phe Lys Lys Ile Glu Cys Phe Asp Ser Val Glu Ile Ser Gly Val 
    770                 775                 780                 


Glu Asp Arg Phe Asn Ala Ser Leu Gly Thr Tyr His Asp Leu Leu Lys 
785                 790                 795                 800 


Ile Ile Lys Asp Lys Asp Phe Leu Asp Asn Glu Glu Asn Glu Asp Ile 
                805                 810                 815     


Leu Glu Asp Ile Val Leu Thr Leu Thr Leu Phe Glu Asp Arg Glu Met 
            820                 825                 830         


Ile Glu Glu Arg Leu Lys Thr Tyr Ala His Leu Phe Asp Asp Lys Val 
        835                 840                 845             


Met Lys Gln Leu Lys Arg Arg Arg Tyr Thr Gly Trp Gly Arg Leu Ser 
    850                 855                 860                 


Arg Lys Leu Ile Asn Gly Ile Arg Asp Lys Gln Ser Gly Lys Thr Ile 
865                 870                 875                 880 


Leu Asp Phe Leu Lys Ser Asp Gly Phe Ala Asn Arg Asn Phe Met Gln 
                885                 890                 895     


Leu Ile His Asp Asp Ser Leu Thr Phe Lys Glu Asp Ile Gln Lys Ala 
            900                 905                 910         


Gln Val Ser Gly Gln Gly Asp Ser Leu His Glu His Ile Ala Asn Leu 
        915                 920                 925             


Ala Gly Ser Pro Ala Ile Lys Lys Gly Ile Leu Gln Thr Val Lys Val 
    930                 935                 940                 


Val Asp Glu Leu Val Lys Val Met Gly Arg His Lys Pro Glu Asn Ile 
945                 950                 955                 960 


Val Ile Glu Met Ala Arg Glu Asn Gln Thr Thr Gln Lys Gly Gln Lys 
                965                 970                 975     


Asn Ser Arg Glu Arg Met Lys Arg Ile Glu Glu Gly Ile Lys Glu Leu 
            980                 985                 990         


Gly Ser Gln Ile Leu Lys Glu His  Pro Val Glu Asn Thr  Gln Leu Gln 
        995                 1000                 1005             


Asn Glu  Lys Leu Tyr Leu Tyr  Tyr Leu Gln Asn Gly  Arg Asp Met 
    1010                 1015                 1020             


Tyr Val  Asp Gln Glu Leu Asp  Ile Asn Arg Leu Ser  Asp Tyr Asp 
    1025                 1030                 1035             


Val Asp  Ala Ile Val Pro Gln  Ser Phe Leu Lys Asp  Asp Ser Ile 
    1040                 1045                 1050             


Asp Asn  Lys Val Leu Thr Arg  Ser Asp Lys Asn Arg  Gly Lys Ser 
    1055                 1060                 1065             


Asp Asn  Val Pro Ser Glu Glu  Val Val Lys Lys Met  Lys Asn Tyr 
    1070                 1075                 1080             


Trp Arg  Gln Leu Leu Asn Ala  Lys Leu Ile Thr Gln  Arg Lys Phe 
    1085                 1090                 1095             


Asp Asn  Leu Thr Lys Ala Glu  Arg Gly Gly Leu Ser  Glu Leu Asp 
    1100                 1105                 1110             


Lys Ala  Gly Phe Ile Lys Arg  Gln Leu Val Glu Thr  Arg Gln Ile 
    1115                 1120                 1125             


Thr Lys  His Val Ala Gln Ile  Leu Asp Ser Arg Met  Asn Thr Lys 
    1130                 1135                 1140             


Tyr Asp  Glu Asn Asp Lys Leu  Ile Arg Glu Val Lys  Val Ile Thr 
    1145                 1150                 1155             


Leu Lys  Ser Lys Leu Val Ser  Asp Phe Arg Lys Asp  Phe Gln Phe 
    1160                 1165                 1170             


Tyr Lys  Val Arg Glu Ile Asn  Asn Tyr His His Ala  His Asp Ala 
    1175                 1180                 1185             


Tyr Leu  Asn Ala Val Val Gly  Thr Ala Leu Ile Lys  Lys Tyr Pro 
    1190                 1195                 1200             


Lys Leu  Glu Ser Glu Phe Val  Tyr Gly Asp Tyr Lys  Val Tyr Asp 
    1205                 1210                 1215             


Val Arg  Lys Met Ile Ala Lys  Ser Glu Gln Glu Ile  Gly Lys Ala 
    1220                 1225                 1230             


Thr Ala  Lys Tyr Phe Phe Tyr  Ser Asn Ile Met Asn  Phe Phe Lys 
    1235                 1240                 1245             


Thr Glu  Ile Thr Leu Ala Asn  Gly Glu Ile Arg Lys  Arg Pro Leu 
    1250                 1255                 1260             


Ile Glu  Thr Asn Gly Glu Thr  Gly Glu Ile Val Trp  Asp Lys Gly 
    1265                 1270                 1275             


Arg Asp  Phe Ala Thr Val Arg  Lys Val Leu Ser Met  Pro Gln Val 
    1280                 1285                 1290             


Asn Ile  Val Lys Lys Thr Glu  Val Gln Thr Gly Gly  Phe Ser Lys 
    1295                 1300                 1305             


Glu Ser  Ile Leu Pro Lys Arg  Asn Ser Asp Lys Leu  Ile Ala Arg 
    1310                 1315                 1320             


Lys Lys  Asp Trp Asp Pro Lys  Lys Tyr Gly Gly Phe  Asp Ser Pro 
    1325                 1330                 1335             


Thr Val  Ala Tyr Ser Val Leu  Val Val Ala Lys Val  Glu Lys Gly 
    1340                 1345                 1350             


Lys Ser  Lys Lys Leu Lys Ser  Val Lys Glu Leu Leu  Gly Ile Thr 
    1355                 1360                 1365             


Ile Met  Glu Arg Ser Ser Phe  Glu Lys Asn Pro Ile  Asp Phe Leu 
    1370                 1375                 1380             


Glu Ala  Lys Gly Tyr Lys Glu  Val Lys Lys Asp Leu  Ile Ile Lys 
    1385                 1390                 1395             


Leu Pro  Lys Tyr Ser Leu Phe  Glu Leu Glu Asn Gly  Arg Lys Arg 
    1400                 1405                 1410             


Met Leu  Ala Ser Ala Gly Glu  Leu Gln Lys Gly Asn  Glu Leu Ala 
    1415                 1420                 1425             


Leu Pro  Ser Lys Tyr Val Asn  Phe Leu Tyr Leu Ala  Ser His Tyr 
    1430                 1435                 1440             


Glu Lys  Leu Lys Gly Ser Pro  Glu Asp Asn Glu Gln  Lys Gln Leu 
    1445                 1450                 1455             


Phe Val  Glu Gln His Lys His  Tyr Leu Asp Glu Ile  Ile Glu Gln 
    1460                 1465                 1470             


Ile Ser  Glu Phe Ser Lys Arg  Val Ile Leu Ala Asp  Ala Asn Leu 
    1475                 1480                 1485             


Asp Lys  Val Leu Ser Ala Tyr  Asn Lys His Arg Asp  Lys Pro Ile 
    1490                 1495                 1500             


Arg Glu  Gln Ala Glu Asn Ile  Ile His Leu Phe Thr  Leu Thr Asn 
    1505                 1510                 1515             


Leu Gly  Ala Pro Ala Ala Phe  Lys Tyr Phe Asp Thr  Thr Ile Asp 
    1520                 1525                 1530             


Arg Lys  Arg Tyr Thr Ser Thr  Lys Glu Val Leu Asp  Ala Thr Leu 
    1535                 1540                 1545             


Ile His  Gln Ser Ile Thr Gly  Leu Tyr Glu Thr Arg  Ile Asp Leu 
    1550                 1555                 1560             


Ser Gln  Leu Gly Gly Asp Gly  Ser Pro Lys Lys Lys  Arg Lys Val 
    1565                 1570                 1575             


Ser Ser  Asp Tyr Lys Asp His  Asp Gly Asp Tyr Lys  Asp His Asp 
    1580                 1585                 1590             


Ile Asp  Tyr Lys Asp Asp Asp  Asp Lys 
    1595                 1600         


<210> 25
<211> 4809
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      FokI-dCas9 polynucleotide

<400> 25
atgcaactag tcaaaagtga actggaggag aagaaatctg aacttcgtca taaattgaaa       60

tatgtgcctc atgaatatat tgaattaatt gaaattgcca gaaattccac tcaggataga      120

attcttgaaa tgaaggtaat ggaatttttt atgaaagttt atggatatag aggtaaacat      180

ttgggtggat caaggaaacc ggacggagca atttatactg tcggatctcc tattgattac      240

ggtgtgatcg tggatactaa agcttatagc ggaggttata atctgccaat tggccaagca      300

gatgaaatgc aacgatatgt cgaagaaaat caaacacgaa acaaacatat caaccctaat      360

gaatggtgga aagtctatcc atcttctgta acggaattta agtttttatt tgtgagtggt      420

cactttaaag gaaactacaa agctcagctt acacgattaa atcatatcac taattgtaat      480

ggagctgttc ttagtgtaga agagctttta attggtggag aaatgattaa agccggcaca      540

ttaaccttag aggaagtcag acggaaattt aataacggcg agataaactt tggtggcggt      600

ggatccgata aaaagtattc tattggttta gccatcggca ctaattccgt tggatgggct      660

gtcataaccg atgaatacaa agtaccttca aagaaattta aggtgttggg gaacacagac      720

cgtcattcga ttaaaaagaa tcttatcggt gccctcctat tcgatagtgg cgaaacggca      780

gaggcgactc gcctgaaacg aaccgctcgg agaaggtata cacgtcgcaa gaaccgaata      840

tgttacttac aagaaatttt tagcaatgag atggccaaag ttgacgattc tttctttcac      900

cgtttggaag agtccttcct tgtcgaagag gacaagaaac atgaacggca ccccatcttt      960

ggaaacatag tagatgaggt ggcatatcat gaaaagtacc caacgattta tcacctcaga     1020

aaaaagctag ttgactcaac tgataaagcg gacctgaggt taatctactt ggctcttgcc     1080

catatgataa agttccgtgg gcactttctc attgagggtg atctaaatcc ggacaactcg     1140

gatgtcgaca aactgttcat ccagttagta caaacctata atcagttgtt tgaagagaac     1200

cctataaatg caagtggcgt ggatgcgaag gctattctta gcgcccgcct ctctaaatcc     1260

cgacggctag aaaacctgat cgcacaatta cccggagaga agaaaaatgg gttgttcggt     1320

aaccttatag cgctctcact aggcctgaca ccaaatttta agtcgaactt cgacttagct     1380

gaagatgcca aattgcagct tagtaaggac acgtacgatg acgatctcga caatctactg     1440

gcacaaattg gagatcagta tgcggactta tttttggctg ccaaaaacct tagcgatgca     1500

atcctcctat ctgacatact gagagttaat actgagatta ccaaggcgcc gttatccgct     1560

tcaatgatca aaaggtacga tgaacatcac caagacttga cacttctcaa ggccctagtc     1620

cgtcagcaac tgcctgagaa atataaggaa atattctttg atcagtcgaa aaacgggtac     1680

gcaggttata ttgacggcgg agcgagtcaa gaggaattct acaagtttat caaacccata     1740

ttagagaaga tggatgggac ggaagagttg cttgtaaaac tcaatcgcga agatctactg     1800

cgaaagcagc ggactttcga caacggtagc attccacatc aaatccactt aggcgaattg     1860

catgctatac ttagaaggca ggaggatttt tatccgttcc tcaaagacaa tcgtgaaaag     1920

attgagaaaa tcctaacctt tcgcatacct tactatgtgg gacccctggc ccgagggaac     1980

tctcggttcg catggatgac aagaaagtcc gaagaaacga ttactccatg gaattttgag     2040

gaagttgtcg ataaaggtgc gtcagctcaa tcgttcatcg agaggatgac caactttgac     2100

aagaatttac cgaacgaaaa agtattgcct aagcacagtt tactttacga gtatttcaca     2160

gtgtacaatg aactcacgaa agttaagtat gtcactgagg gcatgcgtaa acccgccttt     2220

ctaagcggag aacagaagaa agcaatagta gatctgttat tcaagaccaa ccgcaaagtg     2280

acagttaagc aattgaaaga ggactacttt aagaaaattg aatgcttcga ttctgtcgag     2340

atctccgggg tagaagatcg atttaatgcg tcacttggta cgtatcatga cctcctaaag     2400

ataattaaag ataaggactt cctggataac gaagagaatg aagatatctt agaagatata     2460

gtgttgactc ttaccctctt tgaagatcgg gaaatgattg aggaaagact aaaaacatac     2520

gctcacctgt tcgacgataa ggttatgaaa cagttaaaga ggcgtcgcta tacgggctgg     2580

ggacgattgt cgcggaaact tatcaacggg ataagagaca agcaaagtgg taaaactatt     2640

ctcgattttc taaagagcga cggcttcgcc aataggaact ttatgcagct gatccatgat     2700

gactctttaa ccttcaaaga ggatatacaa aaggcacagg tttccggaca aggggactca     2760

ttgcacgaac atattgcgaa tcttgctggt tcgccagcca tcaaaaaggg catactccag     2820

acagtcaaag tagtggatga gctagttaag gtcatgggac gtcacaaacc ggaaaacatt     2880

gtaatcgaga tggcacgcga aaatcaaacg actcagaagg ggcaaaaaaa cagtcgagag     2940

cggatgaaga gaatagaaga gggtattaaa gaactgggca gccagatctt aaaggagcat     3000

cctgtggaaa atacccaatt gcagaacgag aaactttacc tctattacct acaaaatgga     3060

agggacatgt atgttgatca ggaactggac ataaaccgtt tatctgatta cgacgtcgat     3120

gccattgtac cccaatcctt tttgaaggac gattcaatcg acaataaagt gcttacacgc     3180

tcggataaga accgagggaa aagtgacaat gttccaagcg aggaagtcgt aaagaaaatg     3240

aagaactatt ggcggcagct cctaaatgcg aaactgataa cgcaaagaaa gttcgataac     3300

ttaactaaag ctgagagggg tggcttgtct gaacttgaca aggccggatt tattaaacgt     3360

cagctcgtgg aaacccgcca aatcacaaag catgttgcac agatactaga ttcccgaatg     3420

aatacgaaat acgacgagaa cgataagctg attcgggaag tcaaagtaat cactttaaag     3480

tcaaaattgg tgtcggactt cagaaaggat tttcaattct ataaagttag ggagataaat     3540

aactaccacc atgcgcacga cgcttatctt aatgccgtcg tagggaccgc actcattaag     3600

aaatacccga agctagaaag tgagtttgtg tatggtgatt acaaagttta tgacgtccgt     3660

aagatgatcg cgaaaagcga acaggagata ggcaaggcta cagccaaata cttcttttat     3720

tctaacatta tgaatttctt taagacggaa atcactctgg caaacggaga gatacgcaaa     3780

cgacctttaa ttgaaaccaa tggggagaca ggtgaaatcg tatgggataa gggccgggac     3840

ttcgcgacgg tgagaaaagt tttgtccatg ccccaagtca acatagtaaa gaaaactgag     3900

gtgcagaccg gagggttttc aaaggaatcg attcttccaa aaaggaatag tgataagctc     3960

atcgctcgta aaaaggactg ggacccgaaa aagtacggtg gcttcgatag ccctacagtt     4020

gcctattctg tcctagtagt ggcaaaagtt gagaagggaa aatccaagaa actgaagtca     4080

gtcaaagaat tattggggat aacgattatg gagcgctcgt cttttgaaaa gaaccccatc     4140

gacttccttg aggcgaaagg ttacaaggaa gtaaaaaagg atctcataat taaactacca     4200

aagtatagtc tgtttgagtt agaaaatggc cgaaaacgga tgttggctag cgccggagag     4260

cttcaaaagg ggaacgaact cgcactaccg tctaaatacg tgaatttcct gtatttagcg     4320

tcccattacg agaagttgaa aggttcacct gaagataacg aacagaagca actttttgtt     4380

gagcagcaca aacattatct cgacgaaatc atagagcaaa tttcggaatt cagtaagaga     4440

gtcatcctag ctgatgccaa tctggacaaa gtattaagcg catacaacaa gcacagggat     4500

aaacccatac gtgagcaggc ggaaaatatt atccatttgt ttactcttac caacctcggc     4560

gctccagccg cattcaagta ttttgacaca acgatagatc gcaaacgata cacttctacc     4620

aaggaggtgc tagacgcgac actgattcac caatccatca cgggattata tgaaactcgg     4680

atagatttgt cacagcttgg gggtgacgga tcccccaaga agaagaggaa agtctcgagc     4740

gactacaaag accatgacgg tgattataaa gatcatgaca tcgattacaa ggatgacgat     4800

gacaagtga                                                             4809


<210> 26
<211> 1611
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      Nls-FokI-dCas9-nls polypeptide

<400> 26
Met Pro Lys Lys Lys Arg Lys Val Ser Ser Gln Leu Val Lys Ser Glu
 1               5                  10                  15
      
Leu Glu Glu Lys Lys Ser Glu Leu Arg His Lys Leu Lys Tyr Val Pro
            20                  25                  30
          
His Glu Tyr Ile Glu Leu Ile Glu Ile Ala Arg Asn Ser Thr Gln Asp
        35                  40                  45
              
Arg Ile Leu Glu Met Lys Val Met Glu Phe Phe Met Lys Val Tyr Gly
    50                  55                  60
                  
Tyr Arg Gly Lys His Leu Gly Gly Ser Arg Lys Pro Asp Gly Ala Ile
65                  70                  75                  80
  
Tyr Thr Val Gly Ser Pro Ile Asp Tyr Gly Val Ile Val Asp Thr Lys
                85                  90                  95
      
Ala Tyr Ser Gly Gly Tyr Asn Leu Pro Ile Gly Gln Ala Asp Glu Met
            100                 105                 110
         
Gln Arg Tyr Val Glu Glu Asn Gln Thr Arg Asn Lys His Ile Asn Pro
        115                 120                 125
            
Asn Glu Trp Trp Lys Val Tyr Pro Ser Ser Val Thr Glu Phe Lys Phe
    130                 135                 140
                 
Leu Phe Val Ser Gly His Phe Lys Gly Asn Tyr Lys Ala Gln Leu Thr
145                 150                 155                 160
 
Arg Leu Asn His Ile Thr Asn Cys Asn Gly Ala Val Leu Ser Val Glu
                165                 170                 175
     
Glu Leu Leu Ile Gly Gly Glu Met Ile Lys Ala Gly Thr Leu Thr Leu
            180                 185                 190
         
Glu Glu Val Arg Arg Lys Phe Asn Asn Gly Glu Ile Asn Phe Gly Gly
        195                 200                 205
             
Gly Gly Ser Asp Lys Lys Tyr Ser Ile Gly Leu Ala Ile Gly Thr Asn
    210                 215                 220
                 
Ser Val Gly Trp Ala Val Ile Thr Asp Glu Tyr Lys Val Pro Ser Lys
225                 230                 235                 240
 
Lys Phe Lys Val Leu Gly Asn Thr Asp Arg His Ser Ile Lys Lys Asn
                245                 250                 255
     
Leu Ile Gly Ala Leu Leu Phe Asp Ser Gly Glu Thr Ala Glu Ala Thr
            260                 265                 270
         
Arg Leu Lys Arg Thr Ala Arg Arg Arg Tyr Thr Arg Arg Lys Asn Arg
        275                 280                 285
             
Ile Cys Tyr Leu Gln Glu Ile Phe Ser Asn Glu Met Ala Lys Val Asp
    290                 295                 300
                 
Asp Ser Phe Phe His Arg Leu Glu Glu Ser Phe Leu Val Glu Glu Asp
305                 310                 315                 320
 
Lys Lys His Glu Arg His Pro Ile Phe Gly Asn Ile Val Asp Glu Val
                325                 330                 335
     
Ala Tyr His Glu Lys Tyr Pro Thr Ile Tyr His Leu Arg Lys Lys Leu
            340                 345                 350
         
Val Asp Ser Thr Asp Lys Ala Asp Leu Arg Leu Ile Tyr Leu Ala Leu
        355                 360                 365
             
Ala His Met Ile Lys Phe Arg Gly His Phe Leu Ile Glu Gly Asp Leu
    370                 375                 380
                 
Asn Pro Asp Asn Ser Asp Val Asp Lys Leu Phe Ile Gln Leu Val Gln
385                 390                 395                 400
 
Thr Tyr Asn Gln Leu Phe Glu Glu Asn Pro Ile Asn Ala Ser Gly Val
                405                 410                 415
     
Asp Ala Lys Ala Ile Leu Ser Ala Arg Leu Ser Lys Ser Arg Arg Leu
            420                 425                 430
         
Glu Asn Leu Ile Ala Gln Leu Pro Gly Glu Lys Lys Asn Gly Leu Phe
        435                 440                 445
             
Gly Asn Leu Ile Ala Leu Ser Leu Gly Leu Thr Pro Asn Phe Lys Ser
    450                 455                 460
                 
Asn Phe Asp Leu Ala Glu Asp Ala Lys Leu Gln Leu Ser Lys Asp Thr
465                 470                 475                 480
 
Tyr Asp Asp Asp Leu Asp Asn Leu Leu Ala Gln Ile Gly Asp Gln Tyr
                485                 490                 495
     
Ala Asp Leu Phe Leu Ala Ala Lys Asn Leu Ser Asp Ala Ile Leu Leu
            500                 505                 510
         
Ser Asp Ile Leu Arg Val Asn Thr Glu Ile Thr Lys Ala Pro Leu Ser
        515                 520                 525
             
Ala Ser Met Ile Lys Arg Tyr Asp Glu His His Gln Asp Leu Thr Leu
    530                 535                 540
                 
Leu Lys Ala Leu Val Arg Gln Gln Leu Pro Glu Lys Tyr Lys Glu Ile
545                 550                 555                 560
 
Phe Phe Asp Gln Ser Lys Asn Gly Tyr Ala Gly Tyr Ile Asp Gly Gly
                565                 570                 575
     
Ala Ser Gln Glu Glu Phe Tyr Lys Phe Ile Lys Pro Ile Leu Glu Lys
            580                 585                 590
         
Met Asp Gly Thr Glu Glu Leu Leu Val Lys Leu Asn Arg Glu Asp Leu
        595                 600                 605
             
Leu Arg Lys Gln Arg Thr Phe Asp Asn Gly Ser Ile Pro His Gln Ile
    610                 615                 620
                 
His Leu Gly Glu Leu His Ala Ile Leu Arg Arg Gln Glu Asp Phe Tyr
625                 630                 635                 640
 
Pro Phe Leu Lys Asp Asn Arg Glu Lys Ile Glu Lys Ile Leu Thr Phe
                645                 650                 655
     
Arg Ile Pro Tyr Tyr Val Gly Pro Leu Ala Arg Gly Asn Ser Arg Phe
            660                 665                 670
         
Ala Trp Met Thr Arg Lys Ser Glu Glu Thr Ile Thr Pro Trp Asn Phe
        675                 680                 685
             
Glu Glu Val Val Asp Lys Gly Ala Ser Ala Gln Ser Phe Ile Glu Arg
    690                 695                 700
                 
Met Thr Asn Phe Asp Lys Asn Leu Pro Asn Glu Lys Val Leu Pro Lys
705                 710                 715                 720
 
His Ser Leu Leu Tyr Glu Tyr Phe Thr Val Tyr Asn Glu Leu Thr Lys
                725                 730                 735
     
Val Lys Tyr Val Thr Glu Gly Met Arg Lys Pro Ala Phe Leu Ser Gly
            740                 745                 750
        
Glu Gln Lys Lys Ala Ile Val Asp Leu Leu Phe Lys Thr Asn Arg Lys
        755                 760                 765
             
Val Thr Val Lys Gln Leu Lys Glu Asp Tyr Phe Lys Lys Ile Glu Cys
    770                 775                 780
                 
Phe Asp Ser Val Glu Ile Ser Gly Val Glu Asp Arg Phe Asn Ala Ser
785                 790                 795                 800
 
Leu Gly Thr Tyr His Asp Leu Leu Lys Ile Ile Lys Asp Lys Asp Phe
                805                 810                 815
     
Leu Asp Asn Glu Glu Asn Glu Asp Ile Leu Glu Asp Ile Val Leu Thr
            820                 825                 830
         
Leu Thr Leu Phe Glu Asp Arg Glu Met Ile Glu Glu Arg Leu Lys Thr
        835                 840                 845
             
Tyr Ala His Leu Phe Asp Asp Lys Val Met Lys Gln Leu Lys Arg Arg
    850                 855                 860
                 
Arg Tyr Thr Gly Trp Gly Arg Leu Ser Arg Lys Leu Ile Asn Gly Ile
865                 870                 875                 880
 
Arg Asp Lys Gln Ser Gly Lys Thr Ile Leu Asp Phe Leu Lys Ser Asp
                885                 890                 895
     
Gly Phe Ala Asn Arg Asn Phe Met Gln Leu Ile His Asp Asp Ser Leu
            900                 905                 910
         
Thr Phe Lys Glu Asp Ile Gln Lys Ala Gln Val Ser Gly Gln Gly Asp
        915                 920                 925
             
Ser Leu His Glu His Ile Ala Asn Leu Ala Gly Ser Pro Ala Ile Lys
    930                 935                 940
                 
Lys Gly Ile Leu Gln Thr Val Lys Val Val Asp Glu Leu Val Lys Val
945                 950                 955                 960
 
Met Gly Arg His Lys Pro Glu Asn Ile Val Ile Glu Met Ala Arg Glu
                965                 970                 975
     
Asn Gln Thr Thr Gln Lys Gly Gln Lys Asn Ser Arg Glu Arg Met Lys
            980                 985                 990
         
Arg Ile Glu Glu Gly Ile Lys Glu Leu Gly Ser Gln Ile Leu Lys Glu
        995                 1000                1005
            
His Pro Val Glu Asn Thr Gln Leu Gln Asn Glu Lys Leu Tyr Leu Tyr
    1010                1015                1020
                
Tyr Leu Gln Asn Gly Arg Asp Met Tyr Val Asp Gln Glu Leu Asp Ile
1025                1030                1035               1040
 
Asn Arg Leu Ser Asp Tyr Asp Val Asp Ala Ile Val Pro Gln Ser Phe
                1045                1050                1055
    
Leu Lys Asp Asp Ser Ile Asp Asn Lys Val Leu Thr Arg Ser Asp Lys
            1060                1065                1070
        
Asn Arg Gly Lys Ser Asp Asn Val Pro Ser Glu Glu Val Val Lys Lys
        1075                1080                1085
            
Met Lys Asn Tyr Trp Arg Gln Leu Leu Asn Ala Lys Leu Ile Thr Gln
    1090                1095                1100
                
Arg Lys Phe Asp Asn Leu Thr Lys Ala Glu Arg Gly Gly Leu Ser Glu
1105                1110                1115               1120
 
Leu Asp Lys Ala Gly Phe Ile Lys Arg Gln Leu Val Glu Thr Arg Gln
                1125                1130                1135
    
Ile Thr Lys His Val Ala Gln Ile Leu Asp Ser Arg Met Asn Thr Lys
            1140                1145                1150
        
Tyr Asp Glu Asn Asp Lys Leu Ile Arg Glu Val Lys Val Ile Thr Leu
        1155                1160                1165
            
Lys Ser Lys Leu Val Ser Asp Phe Arg Lys Asp Phe Gln Phe Tyr Lys
    1170                1175                1180
                
Val Arg Glu Ile Asn Asn Tyr His His Ala His Asp Ala Tyr Leu Asn
1185                1190                1195               1200
 
Ala Val Val Gly Thr Ala Leu Ile Lys Lys Tyr Pro Lys Leu Glu Ser
                1205                1210                1215
    
Glu Phe Val Tyr Gly Asp Tyr Lys Val Tyr Asp Val Arg Lys Met Ile
            1220                1225                1230
        
Ala Lys Ser Glu Gln Glu Ile Gly Lys Ala Thr Ala Lys Tyr Phe Phe
        1235                1240                1245
            
Tyr Ser Asn Ile Met Asn Phe Phe Lys Thr Glu Ile Thr Leu Ala Asn
    1250                1255                1260
                
Gly Glu Ile Arg Lys Arg Pro Leu Ile Glu Thr Asn Gly Glu Thr Gly
1265                1270                1275               1280
 
Glu Ile Val Trp Asp Lys Gly Arg Asp Phe Ala Thr Val Arg Lys Val
                1285                1290                1295
    
Leu Ser Met Pro Gln Val Asn Ile Val Lys Lys Thr Glu Val Gln Thr
            1300                1305                1310
        
Gly Gly Phe Ser Lys Glu Ser Ile Leu Pro Lys Arg Asn Ser Asp Lys
        1315                1320                1325
            
Leu Ile Ala Arg Lys Lys Asp Trp Asp Pro Lys Lys Tyr Gly Gly Phe
    1330                1335                1340
                
Asp Ser Pro Thr Val Ala Tyr Ser Val Leu Val Val Ala Lys Val Glu
1345                1350                1355               1360
 
Lys Gly Lys Ser Lys Lys Leu Lys Ser Val Lys Glu Leu Leu Gly Ile
                1365                1370                1375
    
Thr Ile Met Glu Arg Ser Ser Phe Glu Lys Asn Pro Ile Asp Phe Leu
            1380                1385                1390
        
Glu Ala Lys Gly Tyr Lys Glu Val Lys Lys Asp Leu Ile Ile Lys Leu
        1395                1400                1405
            
Pro Lys Tyr Ser Leu Phe Glu Leu Glu Asn Gly Arg Lys Arg Met Leu
    1410                1415                1420
                
Ala Ser Ala Gly Glu Leu Gln Lys Gly Asn Glu Leu Ala Leu Pro Ser
1425                1430                1435               1440
 
Lys Tyr Val Asn Phe Leu Tyr Leu Ala Ser His Tyr Glu Lys Leu Lys
                1445                1450                1455
    
Gly Ser Pro Glu Asp Asn Glu Gln Lys Gln Leu Phe Val Glu Gln His
            1460                1465                1470 
       
Lys His Tyr Leu Asp Glu Ile Ile Glu Gln Ile Ser Glu Phe Ser Lys
        1475                1480                1485
            
Arg Val Ile Leu Ala Asp Ala Asn Leu Asp Lys Val Leu Ser Ala Tyr
    1490                1495                1500
                
Asn Lys His Arg Asp Lys Pro Ile Arg Glu Gln Ala Glu Asn Ile Ile
1505                1510                1515               1520
 
His Leu Phe Thr Leu Thr Asn Leu Gly Ala Pro Ala Ala Phe Lys Tyr
                1525                1530                1535
    
Phe Asp Thr Thr Ile Asp Arg Lys Arg Tyr Thr Ser Thr Lys Glu Val
            1540                1545                1550
        
Leu Asp Ala Thr Leu Ile His Gln Ser Ile Thr Gly Leu Tyr Glu Thr
        1555                1560                1565
            
Arg Ile Asp Leu Ser Gln Leu Gly Gly Asp Gly Ser Pro Lys Lys Lys
    1570                1575                1580
                
Arg Lys Val Ser Ser Asp Tyr Lys Asp His Asp Gly Asp Tyr Lys Asp
1585                1590                1595               1600
 
His Asp Ile Asp Tyr Lys Asp Asp Asp Asp Lys
                1605                1610      


<210> 27
<211> 4836
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      Nls-FokI-dCas9-nls polynucleotide

<400> 27
atgcctaaga agaagcggaa ggtgagcagc caacttgtga agtctgaact cgaggagaaa       60

aaatcagagt tgagacacaa gttgaagtac gtgccacacg aatacatcga gcttatcgag      120

atcgccagaa acagtaccca ggataggatc cttgagatga aagtcatgga gttctttatg      180

aaggtctacg gttatagagg aaagcacctt ggcggtagca gaaagcccga tggcgccatc      240

tatactgtcg gatctcctat cgattatggg gtgatcgtgg ataccaaagc ttactcaggc      300

gggtacaact tgcccatagg acaagccgac gagatgcagc ggtatgtcga agagaaccag      360

acgcgcaaca agcacatcaa ccccaatgaa tggtggaaag tgtacccaag tagtgtgact      420

gagttcaagt tcctgtttgt ctccggccac tttaagggca attataaagc tcagctcact      480

agactcaatc acatcacaaa ctgcaacgga gctgtgttgt cagtggagga gctcctgatt      540

ggaggcgaga tgatcaaagc cggcaccctt acactggagg aggtgcggcg gaagttcaac      600

aatggagaga tcaacttcgg tggcggtgga tccgataaaa agtattctat tggtttagcc      660

atcggcacta attccgttgg atgggctgtc ataaccgatg aatacaaagt accttcaaag      720

aaatttaagg tgttggggaa cacagaccgt cattcgatta aaaagaatct tatcggtgcc      780

ctcctattcg atagtggcga aacggcagag gcgactcgcc tgaaacgaac cgctcggaga      840

aggtatacac gtcgcaagaa ccgaatatgt tacttacaag aaatttttag caatgagatg      900

gccaaagttg acgattcttt ctttcaccgt ttggaagagt ccttccttgt cgaagaggac      960

aagaaacatg aacggcaccc catctttgga aacatagtag atgaggtggc atatcatgaa     1020

aagtacccaa cgatttatca cctcagaaaa aagctagttg actcaactga taaagcggac     1080

ctgaggttaa tctacttggc tcttgcccat atgataaagt tccgtgggca ctttctcatt     1140

gagggtgatc taaatccgga caactcggat gtcgacaaac tgttcatcca gttagtacaa     1200

acctataatc agttgtttga agagaaccct ataaatgcaa gtggcgtgga tgcgaaggct     1260

attcttagcg cccgcctctc taaatcccga cggctagaaa acctgatcgc acaattaccc     1320

ggagagaaga aaaatgggtt gttcggtaac cttatagcgc tctcactagg cctgacacca     1380

aattttaagt cgaacttcga cttagctgaa gatgccaaat tgcagcttag taaggacacg     1440

tacgatgacg atctcgacaa tctactggca caaattggag atcagtatgc ggacttattt     1500

ttggctgcca aaaaccttag cgatgcaatc ctcctatctg acatactgag agttaatact     1560

gagattacca aggcgccgtt atccgcttca atgatcaaaa ggtacgatga acatcaccaa     1620

gacttgacac ttctcaaggc cctagtccgt cagcaactgc ctgagaaata taaggaaata     1680

ttctttgatc agtcgaaaaa cgggtacgca ggttatattg acggcggagc gagtcaagag     1740

gaattctaca agtttatcaa acccatatta gagaagatgg atgggacgga agagttgctt     1800

gtaaaactca atcgcgaaga tctactgcga aagcagcgga ctttcgacaa cggtagcatt     1860

ccacatcaaa tccacttagg cgaattgcat gctatactta gaaggcagga ggatttttat     1920

ccgttcctca aagacaatcg tgaaaagatt gagaaaatcc taacctttcg cataccttac     1980

tatgtgggac ccctggcccg agggaactct cggttcgcat ggatgacaag aaagtccgaa     2040

gaaacgatta ctccatggaa ttttgaggaa gttgtcgata aaggtgcgtc agctcaatcg     2100

ttcatcgaga ggatgaccaa ctttgacaag aatttaccga acgaaaaagt attgcctaag     2160

cacagtttac tttacgagta tttcacagtg tacaatgaac tcacgaaagt taagtatgtc     2220

actgagggca tgcgtaaacc cgcctttcta agcggagaac agaagaaagc aatagtagat     2280

ctgttattca agaccaaccg caaagtgaca gttaagcaat tgaaagagga ctactttaag     2340

aaaattgaat gcttcgattc tgtcgagatc tccggggtag aagatcgatt taatgcgtca     2400

cttggtacgt atcatgacct cctaaagata attaaagata aggacttcct ggataacgaa     2460

gagaatgaag atatcttaga agatatagtg ttgactctta ccctctttga agatcgggaa     2520

atgattgagg aaagactaaa aacatacgct cacctgttcg acgataaggt tatgaaacag     2580

ttaaagaggc gtcgctatac gggctgggga cgattgtcgc ggaaacttat caacgggata     2640

agagacaagc aaagtggtaa aactattctc gattttctaa agagcgacgg cttcgccaat     2700

aggaacttta tgcagctgat ccatgatgac tctttaacct tcaaagagga tatacaaaag     2760

gcacaggttt ccggacaagg ggactcattg cacgaacata ttgcgaatct tgctggttcg     2820

ccagccatca aaaagggcat actccagaca gtcaaagtag tggatgagct agttaaggtc     2880

atgggacgtc acaaaccgga aaacattgta atcgagatgg cacgcgaaaa tcaaacgact     2940

cagaaggggc aaaaaaacag tcgagagcgg atgaagagaa tagaagaggg tattaaagaa     3000

ctgggcagcc agatcttaaa ggagcatcct gtggaaaata cccaattgca gaacgagaaa     3060

ctttacctct attacctaca aaatggaagg gacatgtatg ttgatcagga actggacata     3120

aaccgtttat ctgattacga cgtcgatgcc attgtacccc aatccttttt gaaggacgat     3180

tcaatcgaca ataaagtgct tacacgctcg gataagaacc gagggaaaag tgacaatgtt     3240

ccaagcgagg aagtcgtaaa gaaaatgaag aactattggc ggcagctcct aaatgcgaaa     3300

ctgataacgc aaagaaagtt cgataactta actaaagctg agaggggtgg cttgtctgaa     3360

cttgacaagg ccggatttat taaacgtcag ctcgtggaaa cccgccaaat cacaaagcat     3420

gttgcacaga tactagattc ccgaatgaat acgaaatacg acgagaacga taagctgatt     3480

cgggaagtca aagtaatcac tttaaagtca aaattggtgt cggacttcag aaaggatttt     3540

caattctata aagttaggga gataaataac taccaccatg cgcacgacgc ttatcttaat     3600

gccgtcgtag ggaccgcact cattaagaaa tacccgaagc tagaaagtga gtttgtgtat     3660

ggtgattaca aagtttatga cgtccgtaag atgatcgcga aaagcgaaca ggagataggc     3720

aaggctacag ccaaatactt cttttattct aacattatga atttctttaa gacggaaatc     3780

actctggcaa acggagagat acgcaaacga cctttaattg aaaccaatgg ggagacaggt     3840

gaaatcgtat gggataaggg ccgggacttc gcgacggtga gaaaagtttt gtccatgccc     3900

caagtcaaca tagtaaagaa aactgaggtg cagaccggag ggttttcaaa ggaatcgatt     3960

cttccaaaaa ggaatagtga taagctcatc gctcgtaaaa aggactggga cccgaaaaag     4020

tacggtggct tcgatagccc tacagttgcc tattctgtcc tagtagtggc aaaagttgag     4080

aagggaaaat ccaagaaact gaagtcagtc aaagaattat tggggataac gattatggag     4140

cgctcgtctt ttgaaaagaa ccccatcgac ttccttgagg cgaaaggtta caaggaagta     4200

aaaaaggatc tcataattaa actaccaaag tatagtctgt ttgagttaga aaatggccga     4260

aaacggatgt tggctagcgc cggagagctt caaaagggga acgaactcgc actaccgtct     4320

aaatacgtga atttcctgta tttagcgtcc cattacgaga agttgaaagg ttcacctgaa     4380

gataacgaac agaagcaact ttttgttgag cagcacaaac attatctcga cgaaatcata     4440

gagcaaattt cggaattcag taagagagtc atcctagctg atgccaatct ggacaaagta     4500

ttaagcgcat acaacaagca cagggataaa cccatacgtg agcaggcgga aaatattatc     4560

catttgttta ctcttaccaa cctcggcgct ccagccgcat tcaagtattt tgacacaacg     4620

atagatcgca aacgatacac ttctaccaag gaggtgctag acgcgacact gattcaccaa     4680

tccatcacgg gattatatga aactcggata gatttgtcac agcttggggg tgacggatcc     4740

cccaagaaga agaggaaagt ctcgagcgac tacaaagacc atgacggtga ttataaagat     4800

catgacatcg attacaagga tgacgatgac aagtga                               4836


<210> 28
<211> 23
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      primer

<400> 28
gagctggacg gcgacgtaaa cgg                                               23


<210> 29
<211> 23
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      primer

<400> 29
cgccggacac gctgaacttg tgg                                               23


<210> 30
<211> 23
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      primer

<400> 30
ccggcaagct gcccgtgccc tgg                                               23


<210> 31
<211> 23
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      primer

<400> 31
ggtcagggtg gtcacgaggg tgg                                               23


<210> 32
<211> 23
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      primer

<400> 32
cgaggagctg ttcaccgggg tgg                                               23


<210> 33
<211> 23
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      primer

<400> 33
ccgtccagct cgaccaggat ggg                                               23


<210> 34
<211> 23
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      primer

<400> 34
cgaggagctg ttcaccgggg tgg                                               23


<210> 35
<211> 23
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      primer

<400> 35
gccgtccagc tcgaccagga tgg                                               23


<210> 36
<211> 23
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      primer

<400> 36
ccggcaagct gcccgtgccc tgg                                               23


<210> 37
<211> 23
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      primer

<400> 37
gtaggtcagg gtggtcacga ggg                                               23


<210> 38
<211> 23
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      primer

<400> 38
gggcgaggag ctgttcaccg ggg                                               23


<210> 39
<211> 23
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      primer

<400> 39
ccgtccagct cgaccaggat ggg                                               23


<210> 40
<211> 23
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      primer

<400> 40
agggcgagga gctgttcacc ggg                                               23


<210> 41
<211> 23
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      primer

<400> 41
ccgtccagct cgaccaggat ggg                                               23


<210> 42
<211> 23
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      primer

<400> 42
aagggcgagg agctgttcac cgg                                               23


<210> 43
<211> 23
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      primer

<400> 43
ccgtccagct cgaccaggat ggg                                               23


<210> 44
<211> 23
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      primer

<400> 44
aagggcgagg agctgttcac cgg                                               23


<210> 45
<211> 23
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      primer

<400> 45
gccgtccagc tcgaccagga tgg                                               23


<210> 46
<211> 23
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      primer

<400> 46
cagcgtgtcc ggcgagggcg agg                                               23


<210> 47
<211> 23
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      primer

<400> 47
cttcagggtc agcttgccgt agg                                               23


<210> 48
<211> 23
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      primer

<400> 48
gggcgaggag ctgttcaccg ggg                                               23


<210> 49
<211> 23
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      primer

<400> 49
cgtcgccgtc cagctcgacc agg                                               23


<210> 50
<211> 23
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      primer

<400> 50
agggcgagga gctgttcacc ggg                                               23


<210> 51
<211> 23
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      primer

<400> 51
cgtcgccgtc cagctcgacc agg                                               23


<210> 52
<211> 23
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      primer

<400> 52
aagggcgagg agctgttcac cgg                                               23


<210> 53
<211> 23
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      primer

<400> 53
cgtcgccgtc cagctcgacc agg                                               23


<210> 54
<211> 23
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      primer

<400> 54
ctgaagttca tctgcaccac cgg                                               23


<210> 55
<211> 23
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      primer

<400> 55
gtggtcacga gggtgggcca ggg                                               23


<210> 56
<211> 23
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      primer

<400> 56
aagttcagcg tgtccggcga ggg                                               23


<210> 57
<211> 23
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      primer

<400> 57
cttcagggtc agcttgccgt agg                                               23


<210> 58
<211> 23
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      primer

<400> 58
caagttcagc gtgtccggcg agg                                               23


<210> 59
<211> 23
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      primer

<400> 59
cttcagggtc agcttgccgt agg                                               23


<210> 60
<211> 23
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      primer

<400> 60
ggtgcccatc ctggtcgagc tgg                                               23


<210> 61
<211> 23
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      primer

<400> 61
cgccggacac gctgaacttg tgg                                               23


<210> 62
<211> 23
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      primer

<400> 62
gagctggacg gcgacgtaaa cgg                                               23


<210> 63
<211> 23
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      primer

<400> 63
ggcatcgccc tcgccctcgc cgg                                               23


<210> 64
<211> 23
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      primer

<400> 64
ggagcgcacc atcttcttca agg                                               23


<210> 65
<211> 23
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      primer

<400> 65
ctcgaacttc acctcggcgc ggg                                               23


<210> 66
<211> 23
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      primer

<400> 66
ctgaagttca tctgcaccac cgg                                               23


<210> 67
<211> 23
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      primer

<400> 67
gtcagggtgg tcacgagggt ggg                                               23


<210> 68
<211> 23
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      primer

<400> 68
ggccacaagt tcagcgtgtc cgg                                               23


<210> 69
<211> 23
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      primer

<400> 69
cttcagggtc agcttgccgt agg                                               23


<210> 70
<211> 23
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      primer

<400> 70
ctcgtgacca ccctgaccta cgg                                               23


<210> 71
<211> 23
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      primer

<400> 71
cgtgctgctt catgtggtcg ggg                                               23


<210> 72
<211> 23
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      primer

<400> 72
ccggcaagct gcccgtgccc tgg                                               23


<210> 73
<211> 23
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      primer

<400> 73
gctgaagcac tgcacgccgt agg                                               23


<210> 74
<211> 23
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      primer

<400> 74
agcgtgtccg gcgagggcga ggg                                               23


<210> 75
<211> 23
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      primer

<400> 75
ggtggtgcag atgaacttca ggg                                               23


<210> 76
<211> 23
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      primer

<400> 76
cagcgtgtcc ggcgagggcg agg                                               23


<210> 77
<211> 23
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      primer

<400> 77
ggtggtgcag atgaacttca ggg                                               23


<210> 78
<211> 23
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      primer

<400> 78
caccggggtg gtgcccatcc tgg                                               23


<210> 79
<211> 23
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      primer

<400> 79
cgccggacac gctgaacttg tgg                                               23


<210> 80
<211> 23
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      primer

<400> 80
ggcgagggcg atgccaccta cgg                                               23


<210> 81
<211> 23
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      primer

<400> 81
gggcacgggc agcttgccgg tgg                                               23


<210> 82
<211> 23
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      primer

<400> 82
ctcgtgacca ccctgaccta cgg                                               23


<210> 83
<211> 23
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      primer

<400> 83
agaagtcgtg ctgcttcatg tgg                                               23


<210> 84
<211> 23
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      primer

<400> 84
caactacaag acccgcgccg agg                                               23


<210> 85
<211> 23
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      primer

<400> 85
cgatgccctt cagctcgatg cgg                                               23


<210> 86
<211> 23
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      primer

<400> 86
cccatcctgg tcgagctgga cgg                                               23


<210> 87
<211> 23
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      primer

<400> 87
ggcatcgccc tcgccctcgc cgg                                               23


<210> 88
<211> 23
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      primer

<400> 88
caagttcagc gtgtccggcg agg                                               23


<210> 89
<211> 23
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      primer

<400> 89
ggtggtgcag atgaacttca ggg                                               23


<210> 90
<211> 23
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      primer

<400> 90
gagctggacg gcgacgtaaa cgg                                               23


<210> 91
<211> 23
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      primer

<400> 91
gaccaggatg ggcaccaccc cgg                                               23


<210> 92
<211> 23
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      primer

<400> 92
accatcttct tcaaggacga cgg                                               23


<210> 93
<211> 23
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      primer

<400> 93
cgctcctgga cgtagccttc ggg                                               23


<210> 94
<211> 23
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      primer

<400> 94
ggcgagggcg atgccaccta cgg                                               23


<210> 95
<211> 23
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      primer

<400> 95
cgccggacac gctgaacttg tgg                                               23


<210> 96
<211> 23
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      primer

<400> 96
ttcaagtccg ccatgcccga agg                                               23


<210> 97
<211> 23
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      primer

<400> 97
gtcgtgctgc ttcatgtggt cgg                                               23


<210> 98
<211> 23
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      primer

<400> 98
ttcaagtccg ccatgcccga agg                                               23


<210> 99
<211> 23
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      primer

<400> 99
tcgtgctgct tcatgtggtc ggg                                               23


<210> 100
<211> 23
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      primer

<400> 100
ggccacaagt tcagcgtgtc cgg                                               23


<210> 101
<211> 23
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      primer

<400> 101
cgtcgccgtc cagctcgacc agg                                               23


<210> 102
<211> 23
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      primer

<400> 102
ctcgtgacca ccctgaccta cgg                                               23


<210> 103
<211> 23
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      primer

<400> 103
ccagggcacg ggcagcttgc cgg                                               23


<210> 104
<211> 23
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      primer

<400> 104
cagccacaac gtctatatca tgg                                               23


<210> 105
<211> 23
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      primer

<400> 105
tgtactccag cttgtgcccc agg                                               23


<210> 106
<211> 23
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      primer

<400> 106
ggccacaagt tcagcgtgtc cgg                                               23


<210> 107
<211> 23
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      primer

<400> 107
gccgtccagc tcgaccagga tgg                                               23


<210> 108
<211> 23
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      primer

<400> 108
ggccacaagt tcagcgtgtc cgg                                               23


<210> 109
<211> 23
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      primer

<400> 109
ccgtccagct cgaccaggat ggg                                               23


<210> 110
<211> 23
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      primer

<400> 110
aagttcagcg tgtccggcga ggg                                               23


<210> 111
<211> 23
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      primer

<400> 111
cgtcgccgtc cagctcgacc agg                                               23


<210> 112
<211> 23
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      primer

<400> 112
cgcgccgagg tgaagttcga ggg                                               23


<210> 113
<211> 23
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      primer

<400> 113
gccgtcgtcc ttgaagaaga tgg                                               23


<210> 114
<211> 23
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      primer

<400> 114
ccggcaagct gcccgtgccc tgg                                               23


<210> 115
<211> 23
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      primer

<400> 115
cttcagggtc agcttgccgt agg                                               23


<210> 116
<211> 23
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      primer

<400> 116
caagttcagc gtgtccggcg agg                                               23


<210> 117
<211> 23
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      primer

<400> 117
gccgtccagc tcgaccagga tgg                                               23


<210> 118
<211> 23
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      primer

<400> 118
caagttcagc gtgtccggcg agg                                               23


<210> 119
<211> 23
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      primer

<400> 119
ccgtccagct cgaccaggat ggg                                               23


<210> 120
<211> 23
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      primer

<400> 120
aagttcagcg tgtccggcga ggg                                               23


<210> 121
<211> 23
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      primer

<400> 121
ccgtccagct cgaccaggat ggg                                               23


<210> 122
<211> 23
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      primer

<400> 122
agcgtgtccg gcgagggcga ggg                                               23


<210> 123
<211> 23
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      primer

<400> 123
cgtcgccgtc cagctcgacc agg                                               23


<210> 124
<211> 23
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      primer

<400> 124
ctgaagttca tctgcaccac cgg                                               23


<210> 125
<211> 23
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      primer

<400> 125
ggcatcgccc tcgccctcgc cgg                                               23


<210> 126
<211> 23
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      primer

<400> 126
cagcgtgtcc ggcgagggcg agg                                               23


<210> 127
<211> 23
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      primer

<400> 127
gccgtccagc tcgaccagga tgg                                               23


<210> 128
<211> 23
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      primer

<400> 128
ggccacaagt tcagcgtgtc cgg                                               23


<210> 129
<211> 23
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      primer

<400> 129
gaccaggatg ggcaccaccc cgg                                               23


<210> 130
<211> 23
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      primer

<400> 130
agcgtgtccg gcgagggcga ggg                                               23


<210> 131
<211> 23
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      primer

<400> 131
ccgtccagct cgaccaggat ggg                                               23


<210> 132
<211> 23
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      primer

<400> 132
caactacaag acccgcgccg agg                                               23


<210> 133
<211> 23
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      primer

<400> 133
gcgctcctgg acgtagcctt cgg                                               23


<210> 134
<211> 23
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      primer

<400> 134
caactacaag acccgcgccg agg                                               23


<210> 135
<211> 23
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      primer

<400> 135
cgctcctgga cgtagccttc ggg                                               23


<210> 136
<211> 23
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      primer

<400> 136
gctgaagggc atcgacttca agg                                               23


<210> 137
<211> 23
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      primer

<400> 137
cctcgaactt cacctcggcg cgg                                               23


<210> 138
<211> 23
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      primer

<400> 138
caagttcagc gtgtccggcg agg                                               23


<210> 139
<211> 23
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      primer

<400> 139
gaccaggatg ggcaccaccc cgg                                               23


<210> 140
<211> 23
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      primer

<400> 140
aagttcagcg tgtccggcga ggg                                               23


<210> 141
<211> 23
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      primer

<400> 141
gaccaggatg ggcaccaccc cgg                                               23


<210> 142
<211> 23
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      primer

<400> 142
gaagggcatc gacttcaagg agg                                               23


<210> 143
<211> 23
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      primer

<400> 143
cctcgaactt cacctcggcg cgg                                               23


<210> 144
<211> 23
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      primer

<400> 144
caactacaag acccgcgccg agg                                               23


<210> 145
<211> 23
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      primer

<400> 145
ctggacgtag ccttcgggca tgg                                               23


<210> 146
<211> 23
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      primer

<400> 146
ggagcgcacc atcttcttca agg                                               23


<210> 147
<211> 23
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      primer

<400> 147
agaagtcgtg ctgcttcatg tgg                                               23


<210> 148
<211> 23
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      primer

<400> 148
caagttcagc gtgtccggcg agg                                               23


<210> 149
<211> 23
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      primer

<400> 149
cgtcgccgtc cagctcgacc agg                                               23


<210> 150
<211> 23
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      primer

<400> 150
catgcccgaa ggctacgtcc agg                                               23


<210> 151
<211> 23
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      primer

<400> 151
agaagtcgtg ctgcttcatg tgg                                               23


<210> 152
<211> 23
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      primer

<400> 152
caactacaag acccgcgccg agg                                               23


<210> 153
<211> 23
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      primer

<400> 153
tgaagaagat ggtgcgctcc tgg                                               23


<210> 154
<211> 23
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      primer

<400> 154
ggtgaaccgc atcgagctga agg                                               23


<210> 155
<211> 23
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      primer

<400> 155
cctcgaactt cacctcggcg cgg                                               23


<210> 156
<211> 23
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      primer

<400> 156
ttcaagtccg ccatgcccga agg                                               23


<210> 157
<211> 23
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      primer

<400> 157
gcttcatgtg gtcggggtag cgg                                               23


<210> 158
<211> 23
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      primer

<400> 158
ccgcgccgag gtgaagttcg agg                                               23


<210> 159
<211> 23
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      primer

<400> 159
gccgtcgtcc ttgaagaaga tgg                                               23


<210> 160
<211> 23
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      primer

<400> 160
ggtgaaccgc atcgagctga agg                                               23


<210> 161
<211> 23
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      primer

<400> 161
ctcgaacttc acctcggcgc ggg                                               23


<210> 162
<211> 23
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      primer

<400> 162
gtgaaccgca tcgagctgaa ggg                                               23


<210> 163
<211> 23
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      primer

<400> 163
cctcgaactt cacctcggcg cgg                                               23


<210> 164
<211> 23
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      primer

<400> 164
caagatccgc cacaacatcg agg                                               23


<210> 165
<211> 23
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      primer

<400> 165
gatgccgttc ttctgcttgt cgg                                               23


<210> 166
<211> 23
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      primer

<400> 166
gtgaaccgca tcgagctgaa ggg                                               23


<210> 167
<211> 23
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      primer

<400> 167
ctcgaacttc acctcggcgc ggg                                               23


<210> 168
<211> 23
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      primer

<400> 168
caaggaggac ggcaacatcc tgg                                               23


<210> 169
<211> 23
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      primer

<400> 169
tcagctcgat gcggttcacc agg                                               23


<210> 170
<211> 23
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      primer

<400> 170
catgcccgaa ggctacgtcc agg                                               23


<210> 171
<211> 23
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      primer

<400> 171
gtcgtgctgc ttcatgtggt cgg                                               23


<210> 172
<211> 23
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      primer

<400> 172
caaggaggac ggcaacatcc tgg                                               23


<210> 173
<211> 23
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      primer

<400> 173
cagctcgatg cggttcacca ggg                                               23


<210> 174
<211> 23
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      primer

<400> 174
aaggaggacg gcaacatcct ggg                                               23


<210> 175
<211> 23
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      primer

<400> 175
tcagctcgat gcggttcacc agg                                               23


<210> 176
<211> 23
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      primer

<400> 176
aagttcagcg tgtccggcga ggg                                               23


<210> 177
<211> 23
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      primer

<400> 177
gccgtccagc tcgaccagga tgg                                               23


<210> 178
<211> 23
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      primer

<400> 178
catgcccgaa ggctacgtcc agg                                               23


<210> 179
<211> 23
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      primer

<400> 179
tcgtgctgct tcatgtggtc ggg                                               23


<210> 180
<211> 23
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      primer

<400> 180
aaggaggacg gcaacatcct ggg                                               23


<210> 181
<211> 23
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      primer

<400> 181
cagctcgatg cggttcacca ggg                                               23


<210> 182
<211> 23
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      primer

<400> 182
aggaggacgg caacatcctg ggg                                               23


<210> 183
<211> 23
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      primer

<400> 183
tcagctcgat gcggttcacc agg                                               23


<210> 184
<211> 23
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      primer

<400> 184
atccgccaca acatcgagga cgg                                               23


<210> 185
<211> 23
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      primer

<400> 185
gatgccgttc ttctgcttgt cgg                                               23


<210> 186
<211> 23
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      primer

<400> 186
cagcgtgtcc ggcgagggcg agg                                               23


<210> 187
<211> 23
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      primer

<400> 187
cgtcgccgtc cagctcgacc agg                                               23


<210> 188
<211> 23
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      primer

<400> 188
ccggcaagct gcccgtgccc tgg                                               23


<210> 189
<211> 23
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      primer

<400> 189
cagggtcagc ttgccgtagg tgg                                               23


<210> 190
<211> 23
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      primer

<400> 190
catgcccgaa ggctacgtcc agg                                               23


<210> 191
<211> 23
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      primer

<400> 191
cgtgctgctt catgtggtcg ggg                                               23


<210> 192
<211> 23
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      primer

<400> 192
aggaggacgg caacatcctg ggg                                               23


<210> 193
<211> 23
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      primer

<400> 193
cagctcgatg cggttcacca ggg                                               23


<210> 194
<211> 23
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      primer

<400> 194
caacatcctg gggcacaagc tgg                                               23


<210> 195
<211> 23
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      primer

<400> 195
cgatgccctt cagctcgatg cgg                                               23


<210> 196
<211> 23
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      primer

<400> 196
gctgaagggc atcgacttca agg                                               23


<210> 197
<211> 23
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      primer

<400> 197
gtcgccctcg aacttcacct cgg                                               23


<210> 198
<211> 23
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      primer

<400> 198
ccagaagtac gagcgccgcc cgg                                               23


<210> 199
<211> 23
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      primer

<400> 199
tggcaggtga gtgaggctgc agg                                               23


<210> 200
<211> 62
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      RFN target site oligonucleotide 

<400> 200
ccgggcggcg ctcgtacttc tggccactgg gcgagcgtct ggcaggtgag tgaggctgca       60

gg                                                                      62


<210> 201
<211> 23
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      primer

<400> 201
gaatacccat ctgtcagctt cgg                                               23


<210> 202
<211> 23
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      primer

<400> 202
ggcggaacct gagaggcgta agg                                               23


<210> 203
<211> 62
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      RFN target site oligonucleotide 

<400> 203
ccgaagctga cagatgggta ttctttgacg gggggtaggg gcggaacctg agaggcgtaa       60

gg                                                                      62


<210> 204
<211> 23
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      primer

<400> 204
aatattcaag cagcaggcac agg                                               23


<210> 205
<211> 23
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      primer

<400> 205
ctcgcgcagg aggctgcagc ggg                                               23


<210> 206
<211> 62
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      RFN target site oligonucleotide 

<400> 206
cctgtgcctg ctgcttgaat atttccgcct tttagggtgc tcgcgcagga ggctgcagcg       60

gg                                                                      62


<210> 207
<211> 23
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      primer

<400> 207
cccaaagcct ggccagggag tgg                                               23


<210> 208
<211> 23
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      primer

<400> 208
gccccacagg gcttgaagcc cgg                                               23


<210> 209
<211> 62
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      RFN target site oligonucleotide 

<400> 209
ccactccctg gccaggcttt ggggaggcct ggagtcatgg ccccacaggg cttgaagccc       60

gg                                                                      62


<210> 210
<211> 23
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      primer

<400> 210
ccctacttcc gctttcacct tgg                                               23


<210> 211
<211> 23
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      primer

<400> 211
ggaatccctt ctgcagcacc tgg                                               23


<210> 212
<211> 62
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      RFN target site oligonucleotide 

<400> 212
ccaaggtgaa agcggaagta gggccttcgc gcacctcatg gaatcccttc tgcagcacct       60

gg                                                                      62


<210> 213
<211> 23
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      primer

<400> 213
cgctccagag ccgtgcgaat ggg                                               23


<210> 214
<211> 23
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      primer

<400> 214
tggaggcaag agggcggctt tgg                                               23


<210> 215
<211> 62
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      RFN target site oligonucleotide 

<400> 215
cccattcgca cggctctgga gcggcggctg cacaaccagt ggaggcaaga gggcggcttt       60

gg                                                                      62


<210> 216
<211> 23
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      primer

<400> 216
cgaggagact ggggactgta ggg                                               23


<210> 217
<211> 23
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      primer

<400> 217
ccagctgctg ccttgcctcc agg                                               23


<210> 218
<211> 62
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      RFN target site oligonucleotide 

<400> 218
ccctacagtc cccagcctcc tcgtcccatg cctccgtctc cagctgctgc cttgcctcca       60

gg                                                                      62


<210> 219
<211> 23
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      primer

<400> 219
catagctact gattggtggt ggg                                               23


<210> 220
<211> 23
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      primer

<400> 220
ccggcccctc cccagtcagg ggg                                               23


<210> 221
<211> 62
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      RFN target site oligonucleotide 

<400> 221
cccaccacca atcagtagct atggcgagcc ctgctgtctc cggcccctcc ccagtcaggg       60

gg                                                                      62


<210> 222
<211> 23
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      primer

<400> 222
ggaaacgtct agatgctcaa cgg                                               23


<210> 223
<211> 23
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      primer

<400> 223
caaaatgtcg ttcgtggcag tgg                                               23


<210> 224
<211> 62
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      RFN target site oligonucleotide 

<400> 224
ccgttgagca tctagacgtt tccttggctc ttctggcgcc aaaatgtcgt tcgtggcagg       60

gg                                                                      62


<210> 225
<211> 23
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      primer

<400> 225
ctgttgctgg ccatgccaag cgg                                               23


<210> 226
<211> 23
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      primer

<400> 226
cctgggggcg ggcacctcaa tgg                                               23


<210> 227
<211> 62
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      RFN target site oligonucleotide 

<400> 227
ccgcttggca tggccagcaa cagcagctcc tgcccgacac ctgggggcgg gcacctcaat       60

gg                                                                      62


<210> 228
<211> 23
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      primer

<400> 228
ttcggagcga aaaccaagac agg                                               23


<210> 229
<211> 23
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      primer

<400> 229
gagtcccccg ccttcagaag agg                                               23


<210> 230
<211> 62
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      RFN target site oligonucleotide 

<400> 230
cctgtcttgg ttttcgctcc gaaggtaaaa gaaatcattg agtcccccgc cttcagaaga       60

gg                                                                      62


<210> 231
<211> 23
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      primer

<400> 231
ggcccggtcg actccgggcc cgg                                               23


<210> 232
<211> 23
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      primer

<400> 232
tgctgggaat cagcagtgtt tgg                                               23


<210> 233
<211> 62
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      RFN target site oligonucleotide 

<400> 233
ccgggcccgg agtcgaccgg gccgaggcgg aggcgggcct gctgggaatc agcagtgttt       60

gg                                                                      62


<210> 234
<211> 23
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      primer

<400> 234
gggtgggggg agtttgctcc tgg                                               23


<210> 235
<211> 23
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      primer

<400> 235
tccctcttta gccagagccg ggg                                               23


<210> 236
<211> 62
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      RFN target site oligonucleotide 

<400> 236
ccaggagcaa actcccccca ccccctttcc aaagcccatt ccctctttag ccagagccgg       60

gg                                                                      62


<210> 237
<211> 23
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      primer

<400> 237
gccgccggcc ggggaggagg tgg                                               23


<210> 238
<211> 23
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      primer

<400> 238
ggcgagccgc gggcaggggc cgg                                               23


<210> 239
<211> 62
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      RFN target site oligonucleotide 

<400> 239
ccacctcctc cccggccggc ggcggacagt ggacgcggcg gcgagccgcg ggcaggggcc       60

gg                                                                      62


<210> 240
<211> 23
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      primer

<400> 240
ccgtctgcac accccggctc tgg                                               23


<210> 241
<211> 23
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      primer

<400> 241
ctcggccacc acagggaagc tgg                                               23


<210> 242
<211> 62
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      RFN target site oligonucleotide 

<400> 242
ccagagccgg ggtgtgcaga cggcagtcac tagggggcgc tcggccacca cagggaagct       60

gg                                                                      62


<210> 243
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      primer

<400> 243
ggctgtggga agccagcaac                                                   20


<210> 244
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      primer

<400> 244
aagccagggg ccaactggag                                                   20


<210> 245
<211> 26
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      primer

<400> 245
gcgcgggaat tacagataaa ttaaaa                                            26


<210> 246
<211> 25
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      primer

<400> 246
aggtcccatc ctctcataca tacca                                             25


<210> 247
<211> 18
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      primer

<400> 247
accgcccctt ggcaccac                                                     18


<210> 248
<211> 21
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      primer

<400> 248
cggagctcat ctgcttcctg t                                                 21


<210> 249
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      primer

<400> 249
ggagcagctg gtcagagggg                                                   20


<210> 250
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      primer

<400> 250
gggaaggggg acactgggga                                                   20


<210> 251
<211> 23
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      primer

<400> 251
gccctacatc tgctctccct cca                                               23


<210> 252
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      primer

<400> 252
gggccgggaa agagttgctg                                                   20


<210> 253
<211> 23
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      primer

<400> 253
gccctacatc tgctctccct cca                                               23


<210> 254
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      primer

<400> 254
gggccgggaa agagttgctg                                                   20


<210> 255
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      primer

<400> 255
ggggagggag gctccaggtt                                                   20


<210> 256
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      primer

<400> 256
ggcacaatgg ctcccaagca                                                   20


<210> 257
<211> 21
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      primer

<400> 257
ccttacccct cccctcactc a                                                 21


<210> 258
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      primer

<400> 258
agaagggcgg gccagacagt                                                   20


<210> 259
<211> 28
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      primer

<400> 259
atatccttct aggtagcggg cagtagcc                                          28


<210> 260
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      primer

<400> 260
tctcggggga gagcggtaaa                                                   20


<210> 261
<211> 21
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      primer

<400> 261
cccaggaaaa gtgccagctc a                                                 21


<210> 262
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      primer

<400> 262
tgatggtcac cccaactgga                                                   20


<210> 263
<211> 19
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      primer

<400> 263
aaggcggcgc tggcttttt                                                    19


<210> 264
<211> 24
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      primer

<400> 264
ccagcacaac ttactcgcac ttga                                              24


<210> 265
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      primer

<400> 265
gggatgcagg gacggtcaag                                                   20


<210> 266
<211> 21
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      primer

<400> 266
gccgccccat ccctagagaa a                                                 21


<210> 267
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      primer

<400> 267
tccagatggc acattgtcag                                                   20


<210> 268
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      primer

<400> 268
agggagcagg aaagtgaggt                                                   20


<210> 269
<211> 22
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      primer

<400> 269
agagaagtcg aggaagagag ag                                                22


<210> 270
<211> 22
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      primer

<400> 270
cagcagaaag ttcatggttt cg                                                22


<210> 271
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      primer

<400> 271
tccagatggc acattgtcag                                                   20


<210> 272
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      primer

<400> 272
agggagcagg aaagtgaggt                                                   20


<210> 273
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      primer

<400> 273
cgatggctcc caagaaacgc                                                   20


<210> 274
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      primer

<400> 274
gcaggtagaa tgcacagccg                                                   20


<210> 275
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      primer

<400> 275
gcccagagtc aaggaacacg                                                   20


<210> 276
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      primer

<400> 276
aggtagtgct tgagaccgcc                                                   20


<210> 277
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      primer

<400> 277
catccatcgg cgctttggtc                                                   20


<210> 278
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      primer

<400> 278
ccgggaaaga gttgctgcac                                                   20


<210> 279
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      primer

<400> 279
ctccccgtct gcagtccatc                                                   20


<210> 280
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      primer

<400> 280
cctgcaggga catgtggtga                                                   20


<210> 281
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      primer

<400> 281
tagggctaga ggggtgaggc                                                   20


<210> 282
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      primer

<400> 282
ccgaggtgaa acaagctgcc                                                   20


<210> 283
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      primer

<400> 283
atgagggctc cagatggcac                                                   20


<210> 284
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      primer

<400> 284
ttcacccagc ttccctgtgg                                                   20


<210> 285
<211> 1752
<212> DNA
<213> Planomicrobium okeanokoites

<400> 285
atgtttttga gtatggtttc taaaataaga actttcggtt gggttcaaaa tccaggtaaa       60

tttgagaatt taaaacgagt agttcaagta tttgatagaa attctaaagt acataatgaa      120

gtgaaaaata taaagatacc aaccctagtc aaagaaagta agatccaaaa agaactagtt      180

gctattatga atcaacatga tttgatttat acatataaag agttagtagg aacaggaact      240

tcaatacgtt cagaagcacc atgcgatgca attattcaag caacaatagc agatcaagga      300

aataaaaaag gctatatcga taattggtca tctgacggtt ttttgcgttg ggcacatgct      360

ttaggattta ttgaatatat aaataaaagt gattcttttg taataactga tgttggactt      420

gcttactcta aatcagctga cggcagcgcc attgaaaaag agattttgat tgaagcgata      480

tcatcttatc ctccagcgat tcgtatttta actttgctag aagatggaca acatttgaca      540

aagtttgatc ttggcaagaa tttaggtttt agtggagaaa gtggatttac ttctctaccg      600

gaaggaattc ttttagatac tctagctaat gctatgccta aagataaagg cgaaattcgt      660

aataattggg aaggatcttc agataagtac gcaagaatga taggtggttg gctggataaa      720

ctaggattag taaagcaagg aaaaaaagaa tttatcattc ctactttggg taagccggac      780

aataaagagt ttatatccca cgcttttaaa attactggag aaggtttgaa agtactgcgt      840

cgagcaaaag gctctacaaa atttacacgt gtacctaaaa gagtatattg ggaaatgctt      900

gctacaaacc taaccgataa agagtatgta agaacaagaa gagctttgat tttagaaata      960

ttaatcaaag ctggatcatt aaaaatagaa caaatacaag acaacttgaa gaaattagga     1020

tttgatgaag ttatagaaac tattgaaaat gatatcaaag gcttaattaa cacaggtata     1080

tttatagaaa tcaaagggcg attttatcaa ttgaaagacc atattcttca atttgtaata     1140

cctaatcgtg gtgtgactaa gcaactagtc aaaagtgaac tggaggagaa gaaatctgaa     1200

cttcgtcata aattgaaata tgtgcctcat gaatatattg aattaattga aattgccaga     1260

aattccactc aggatagaat tcttgaaatg aaggtaatgg aattttttat gaaagtttat     1320

ggatatagag gtaaacattt gggtggatca aggaaaccgg acggagcaat ttatactgtc     1380

ggatctccta ttgattacgg tgtgatcgtg gatactaaag cttatagcgg aggttataat     1440

ctgccaattg gccaagcaga tgaaatgcaa cgatatgtcg aagaaaatca aacacgaaac     1500

aaacatatca accctaatga atggtggaaa gtctatccat cttctgtaac ggaatttaag     1560

tttttatttg tgagtggtca ctttaaagga aactacaaag ctcagcttac acgattaaat     1620

catatcacta attgtaatgg agctgttctt agtgtagaag agcttttaat tggtggagaa     1680

atgattaaag ccggcacatt aaccttagag gaagtgagac ggaaatttaa taacggcgag     1740

ataaactttt aa                                                         1752


<210> 286
<211> 23
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      target binding site oligonucleotide

<400> 286
ggtgagtgag tgtgtgcgtg tgg                                               23


<210> 287
<211> 18
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      target binding site oligonucleotide

<400> 287
gggcgatgcc acctacgg                                                     18


<210> 288
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      target binding site oligonucleotide

<400> 288
gagggcgatg ccacctacgg                                                   20


<210> 289
<211> 22
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      target binding site oligonucleotide

<400> 289
gcgagggcga tgccacctac gg                                                22


<210> 290
<211> 23
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      target binding site oligonucleotide

<400> 290
ggcgagggcg atgccaccta cgg                                               23


<210> 291
<211> 24
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      target binding site oligonucleotide

<400> 291
gggcgagggc gatgccacct acgg                                              24


<210> 292
<211> 26
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      target binding site oligonucleotide

<400> 292
gagggcgagg gcgatgccac ctacgg                                            26


<210> 293
<211> 28
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      target binding site oligonucleotide

<400> 293
gcgcgggcga gggcgatgcc acctacgg                                          28


<210> 294
<211> 21
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      target binding site oligonucleotide

<400> 294
gcacgggcag cttgccggtg g                                                 21


<210> 295
<211> 23
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      target binding site oligonucleotide

<400> 295
gggcacgggc agcttgccgg tgg                                               23


<210> 296
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      target binding site oligonucleotide

<400> 296
gccgttcttc tgcttgtcgg                                                   20


<210> 297
<211> 23
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      target binding site oligonucleotide

<400> 297
gatgccgttc ttctgcttgt cgg                                               23


<210> 298
<211> 19
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      target binding site oligonucleotide

<400> 298
gtgcagatga acttcaggg                                                    19


<210> 299
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      target binding site oligonucleotide

<400> 299
ggtgcagatg aacttcaggg                                                   20


<210> 300
<211> 23
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      target binding site oligonucleotide

<400> 300
ggtggtgcag atgaacttca ggg                                               23


<210> 301
<211> 19
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      target binding site oligonucleotide

<400> 301
gaggagctgt tcaccgggg                                                    19


<210> 302
<211> 21
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      target binding site oligonucleotide

<400> 302
gcgaggagct gttcaccggg g                                                 21


<210> 303
<211> 23
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      target binding site oligonucleotide

<400> 303
gggcgaggag ctgttcaccg ggg                                               23


<210> 304
<211> 21
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      target binding site oligonucleotide

<400> 304
gtggggggag tttgctcctg g                                                 21


<210> 305
<211> 23
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      target binding site oligonucleotide

<400> 305
gggtgggggg agtttgctcc tgg                                               23


<210> 306
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      target binding site oligonucleotide

<400> 306
gagtgagtgt gtgcgtgtgg                                                   20


<210> 307
<211> 23
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      target binding site oligonucleotide

<400> 307
ggtgagtgag tgtgtgcgtg tgg                                               23


<210> 308
<211> 21
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      target binding site oligonucleotide

<400> 308
gtccgagcag aagaagaagg g                                                 21


<210> 309
<211> 23
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      target binding site oligonucleotide

<400> 309
gagtccgagc agaagaagaa ggg                                               23


<210> 310
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      target binding site oligonucleotide

<400> 310
gatgtagtgt ttccacaggg                                                   20


<210> 311
<211> 23
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      target binding site oligonucleotide

<400> 311
gcagatgtag tgtttccaca ggg                                               23


<210> 312
<211> 67
<212> DNA
<213> Homo sapiens

<400> 312
gaagctggag gaggaagggc ctgagtccga gcagaagaag aagggctccc atcacatcaa       60

ccggtgg                                                                 67


<210> 313
<211> 15
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide

<400> 313
gaagctggag gagga                                                        15


<210> 314
<211> 11
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide

<400> 314
tcaaccggtg g                                                            11


<210> 315
<211> 18
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide

<400> 315
gaagctggag gaggaagg                                                     18


<210> 316
<211> 25
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide

<400> 316
gggctcccat cacatcaacc ggtgg                                             25


<210> 317
<211> 24
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide

<400> 317
gaagctggag gaggaagggc ctga                                              24


<210> 318
<211> 14
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide

<400> 318
gaagctggag gagg                                                         14


<210> 319
<211> 39
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide

<400> 319
gaagctggag gaggaagggc ccatcacatc aaccggtgg                              39


<210> 320
<211> 40
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide

<400> 320
gaagctggag gaggaagggc tcgcacacat caaccggtgg                             40


<210> 321
<211> 42
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide

<400> 321
gaagctggag gaggaagggc cttccatcac atcaaccggt gg                          42


<210> 322
<211> 46
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide

<400> 322
gaagctggag gaggaagggc ctgagtccca tcacatcaac cggtgg                      46


<210> 323
<211> 52
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide

<400> 323
gaagctggag gaggaagggc ctgagtccga gtcccatcac atcaaccggt gg               52


<210> 324
<211> 58
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide

<400> 324
gaagctggag gaggaagggc ctgagtccga gcagaagtcc catcacatca accggtgg         58


<210> 325
<211> 59
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide

<400> 325
gaagctggag gaggaagggc ctgagtcctg ccgtttgtag ccatcacatc aaccggtgg        59


<210> 326
<211> 61
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide

<400> 326
gaagctggag gaggaagggc ctgagtccga gcagaagagc tcccatcaca tcaaccggtg       60

g                                                                       61


<210> 327
<211> 61
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide

<400> 327
gaagctggag gaggaagggc ctgagtccga gcagaagaac tcccatcaca tcaaccggtg       60

g                                                                       61


<210> 328
<211> 64
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide

<400> 328
gaagctggag gaggaagggc ctgagtccga gcagaagaag ggctcccatc acatcaaccg       60

gtgg                                                                    64


<210> 329
<211> 65
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide

<400> 329
gaagctggag gaggaagggc ctgagtccga gcagaagaaa gggctcccat cacatcaacc       60

ggtgg                                                                   65


<210> 330
<211> 67
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide

<400> 330
gaagctggag gaggaagggc ctgagtccga gcagaagaac agaagggctc ccatcacatc       60

aaccggt                                                                 67


<210> 331
<211> 67
<212> DNA
<213> Homo sapiens

<400> 331
gaagctggag gaggaagggc ctgagtccga gcagaagaag aagggctccc atcacatcaa       60

ccggtgg                                                                 67


<210> 332
<211> 31
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide

<400> 332
gaagctggag gaggaagggc ctgagtccga g                                      31


<210> 333
<211> 11
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide

<400> 333
gaagctggag g                                                            11


<210> 334
<211> 11
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide

<400> 334
gaagctggag g                                                            11


<210> 335
<211> 28
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide

<400> 335
gaagctggag gaggaagggc ctgagtgg                                          28


<210> 336
<211> 41
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide

<400> 336
gaagctggag gaggaagggc tcccatcaca tcaaccggtg g                           41


<210> 337
<211> 45
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide

<400> 337
gaagctggag gaggaagggc ctgagtccat cacatcaacc ggtgg                       45


<210> 338
<211> 46
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide

<400> 338
gaagctggag gaggaagggc ctgagtccca tcacatcaac cggtgg                      46


<210> 339
<211> 49
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide

<400> 339
gaagctggag gaggaagggc ctgagtccga gcatcacatc aaccggtgg                   49


<210> 340
<211> 53
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide

<400> 340
gaagctggag gaggaagggc ctgagtccga gctcccatca catcaaccgg tgg              53


<210> 341
<211> 61
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide

<400> 341
gaagctggag gaggaagggc ctgagtccga gcagaagggc tcccatcaca tcaaccggtg       60

g                                                                       61


<210> 342
<211> 64
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide

<400> 342
gaagctggag gaggaagggc ctgagtccga gcagaagaag ggctcccatc acatcaaccg       60

gtgg                                                                    64


<210> 343
<211> 65
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide

<400> 343
gaagctggag gaggaagggc ctgagtccga gcagaaagaa gggctcccat cacatcaacc       60

ggtgg                                                                   65


<210> 344
<211> 67
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide

<400> 344
gaagctggag gaggaagggc ctgagtccga gcagaagaac agaagggctc ccatcacatc       60

aaccggt                                                                 67


<210> 345
<211> 187
<212> DNA
<213> Aequorea victoria

<400> 345
tcgtgaccac cctgacctac ggcgtgcagt gcttcagccg ctaccccgac cacatgaagc       60

agcacgactt cttcaagtcc gccatgcccg aaggctacgt ccaggagcgc accatcttct      120

tcaaggagac ggcaactaca agacccgcgc cgaggtgaag ttcgagggcg acaccctggt      180

gaaccgc                                                                187


<210> 346
<211> 184
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      polynucleotide

<400> 346
tcgtgaccac cctgacctac gtgcagtgct tcagccgcta ccccgaccac atgaagcagc       60

acgacttctt caagtccgcc atgcccgaag gctacgtcca ggagcgcacc atcttcttca      120

aggacgacgg caactacaag acccgcgcga ggtgaagttc gagggcgaca ccctggtgaa      180

ccgc                                                                   184


<210> 347
<211> 159
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      polynucleotide

<400> 347
tcgtgaccac cctgacctca gccgctaccc cgaccacatg aagcagcacg acttcttcaa       60

gtccgccatg cccgaaggct acgtccagga gcgcaccatc ttcttcaagg acgacggcaa      120

ctacaagacc cgcgccgagg cgacaccctg gtgaaccgc                             159


<210> 348
<211> 154
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      polynucleotide

<400> 348
tcgtgaccac cctgacctac ggcgtgcagt gcttcagccg ctaccccgac cacatgaagc       60

agcacgactt cttcaagtcc gccatgcccg aaggctacgt ccaggagcgc accatcttct      120

tcaaggagac ggcaactaca ccctggtgaa ccgc                                  154


<210> 349
<211> 181
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      polynucleotide

<400> 349
tcgtgaccac cctgaccgtg cagtgcttca gccgctaccc cgaccacatg aagcagcacg       60

acttcttcaa gtccgccatg cccgaaggct acgtccagga gcgcaccatc ttcttcaagg      120

acgacggcaa ctacaagacc cgcgcgaggg tcttgttcga gggcgacacc ctggtgaacc      180

g                                                                      181


<210> 350
<211> 53
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide

<400> 350
tcgtgaccac cctgacctac gtgaagttcg agggcgacac cctggtgaac cgc              53


<210> 351
<211> 187
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      polynucleotide

<400> 351
tcgtgaccac cctgacctac gcctcggcgc gggtcttgta gttgccgtcg tccttgaaga       60

agatggtgcg ctcctggacg tagccttcgg gcatggcgga cttgaagaag tcgtgctgct      120

tcatgtgtcg gggtagcggc tgaagcactg cacgctgaag ttcgagggcg acaccctggt      180

gaaccgc                                                                187


<210> 352
<211> 146
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      polynucleotide

<400> 352
tcggcgcggg tcttgtagtt gccgtcgtcc ttgaagaaga tggtgcgctc ctggacgtag       60

ccttcgggca tggcggactt gaagaagtcg tgctgcttca tgtggtcggg gtagcggctg      120

aagcactgca caccctggtg aaccgc                                           146


<210> 353
<211> 41
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide

<400> 353
tcgtgaccac cctgttcgag ggcgacaccc tggtgaaccg c                           41


<210> 354
<211> 92
<212> DNA
<213> Homo sapiens

<400> 354
caggagacga agagcccggg cggcgctcgt acttctggcc actgggcgag cgtctggcag       60

gtgagtgagg ctgcaggcat tgacgtctcc tc                                     92


<210> 355
<211> 92
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide

<400> 355
caggagacga agagcccggg cggcgctcgt acttctggcc actggcgaag cgtctggcag       60

gtgagtgagg ctgcaggcat tgacgtctcc tc                                     92


<210> 356
<211> 80
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide

<400> 356
caggagacga agagcccggg cggcgctcgt acttctggcc tctggcaggt gagtgaggct       60

gcaggcattg acgtctcctc                                                   80


<210> 357
<211> 80
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide

<400> 357
caggagacga agagcccggg cggcgctcgt acttctagcg tctggcaggt gagtgaggct       60

gcaggcattg acgtctcctc                                                   80


<210> 358
<211> 76
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide

<400> 358
caggagacga agagcccggg cggcgctcgt acttcgtctg gcaggtgagt gaggctgcag       60

gcattgacgt ctcctc                                                       76


<210> 359
<211> 75
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide

<400> 359
caggagacga agagcccggg cggcgctcgt acttctggcc actgtgagtg aggctgcagg       60

cattgacgtc tcctc                                                        75


<210> 360
<211> 73
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide

<400> 360
caggagacga agagcccggg cggcgctcgt acttctggca ggtgagtgag gctgcaggca       60

ttgacgtctc ctc                                                          73


<210> 361
<211> 69
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide

<400> 361
caggagacga agagcccggg cggcgctcgt ctggcaggtg agtgaggctg caggcattga       60

cgtctcctc                                                               69


<210> 362
<211> 58
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide

<400> 362
caggagacga agagcccgtc tggcaggtga gtgaggctgc aggcattgac gtctcctc         58


<210> 363
<211> 46
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide

<400> 363
accggcggca gcaggtgagt gaggctgcag gcattgacgt ctcctc                      46


<210> 364
<211> 92
<212> DNA
<213> Homo sapiens

<400> 364
tgggagagtg gatttccgaa gctgacagat gggtattctt tgaggggggg taggggcgga       60

acctgagagg cgtaaggcgt tgtgaaccct gg                                     92


<210> 365
<211> 86
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide

<400> 365
tgggagagtg gatttccgaa gctgacagat gggtattctt tgagtagggg cggaacctga       60

gaggcgtaag gcgttgtgaa ccctgg                                            86


<210> 366
<211> 84
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide

<400> 366
tgggagagtg gatttccgaa gctgacagat gggtatgggg ggtaggggcg gaacctgaga       60

ggcgtaaggc gttgtgaacc ctgg                                              84


<210> 367
<211> 84
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide

<400> 367
tgggagagtg gatttccgaa gctgacagat gggtattctt ggtaggggcg gaacctgaga       60

ggcgtaaggc gttgtgaacc ctgg                                              84


<210> 368
<211> 82
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide

<400> 368
tgggagagtg gatttccgaa gctgacagat gggtattctt tgagggggga acctgagagg       60

cgtaaggcgt tgtgaaccct gg                                                82


<210> 369
<211> 80
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide

<400> 369
tgggagagtg gatttccgaa gctgacagat gggtattctt tgggcggaac ctgagaggcg       60

taaggcgttg tgaaccctgg                                                   80


<210> 370
<211> 70
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide

<400> 370
tgggagagtg gatttccgaa gctgacagat ggggcggaac ctgagaggcg taaggcgttg       60

tgaaccctgg                                                              70


<210> 371
<211> 92
<212> DNA
<213> Homo sapiens

<400> 371
caagctggac tctggccact ccctggccag gctttgggga ggcctggagt catggcccca       60

cagggcttga agcccggggg gccgccattg ac                                     92


<210> 372
<211> 76
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide

<400> 372
caagctggac tctggccact ccctggccag gctttatggc cccacagggc ttgaagcccg       60

gggggccgcc attgac                                                       76


<210> 373
<211> 92
<212> DNA
<213> Homo sapiens

<400> 373
agagagtcgc cgtctccaag gtgaaagcgg aagtagggcc ttcgcgcacc tcatggaatc       60

ccttctgcag cacctggatc gcttttccga gc                                     92


<210> 374
<211> 84
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide

<400> 374
agagagtcgc cgtctccaag gtgaaagcgg aagtagcgca cctcatggaa tcccttctgc       60

agcacctgga tcgcttttcc gagc                                              84


<210> 375
<211> 83
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide

<400> 375
agagagtcgc cgtctccaag gtgaaagcgg aagtagggcc ctcatggaat cccttctgca       60

gcacctggat cgcttttccg agc                                               83


<210> 376
<211> 82
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide

<400> 376
agagagtcgc cgtctccaag gtgaaagcgg aagtaggccc tcatggaatc ccttctgcag       60

cacctggatc gcttttccga gc                                                82


<210> 377
<211> 82
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide

<400> 377
agagagtcgc cgtctccaag gtgaaagcgg aagtagggcc tcatggaatc ccttctgcag       60

cacctggatc gcttttccga gc                                                82


<210> 378
<211> 82
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide

<400> 378
agagagtcgc cgtctccaag gtgaaagcgg aagtagcacc tcatggaatc ccttctgcag       60

cacctggatc gcttttccga gc                                                82


<210> 379
<211> 81
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide

<400> 379
agagagtcgc cgtctccaag gtgaaagcgg aaacgcacct catggaatcc cttctgcagc       60

acctggatcg cttttccgag c                                                 81


<210> 380
<211> 78
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide

<400> 380
agagagtcgc cgtctccaag gtgaaagcgg aagtagggcc ttcgcgcatt ctgcagcacc       60

tggatcgctt ttccgagc                                                     78


<210> 381
<211> 77
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide

<400> 381
agagagtcgc cgtctccaag gtgaaagcgg aagcctcatg gaatcccttc tgcagcacct       60

ggatcgcttt tccgagc                                                      77


<210> 382
<211> 61
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide

<400> 382
agagagtcgc cgtctccaag catggaatcc cttctgcagc acctggatcg cttttccgag       60

c                                                                       61


<210> 383
<211> 92
<212> DNA
<213> Homo sapiens

<400> 383
tttggtcggc atggccccat tcgcacggct ctggagcggc ggctgcacaa ccagtggagg       60

caagagggcg gctttgggcg gggtccagtt cc                                     92


<210> 384
<211> 89
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide

<400> 384
tttggtcggc atggccccat tcgcacggct ctggagcggc ggcgcaacca gtggaggcaa       60

gagggcggct ttgggcgggg tccagttcc                                         89


<210> 385
<211> 88
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide

<400> 385
tttggtcggc atggccccat tcgcacggct ctggagcggc ggctaaccag tggaggcaag       60

agggcggctt tgggcggggt ccagttcc                                          88


<210> 386
<211> 84
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide

<400> 386
tttggtcggc atggccccat tcgcacggct ctggagcggc ggccagtgga ggcaagaggg       60

cggctttggg cggggtccag ttcc                                              84


<210> 387
<211> 83
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide

<400> 387
tttggtcggc atggccccat tcgcacggct ctggagcggc ggctgtggag gcaagagggc       60

ggctttgggc ggggtccagt tcc                                               83


<210> 388
<211> 81
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide

<400> 388
tttggtcggc atggccccat tcgcacggct ctggagcggc ggctggaggc aagagggcgg       60

ctttgggcgg ggtccagttc c                                                 81


<210> 389
<211> 80
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide

<400> 389
tttggtcggc atggccccat tcgcacggct ctggagcggc gggagaggca agagggcggc       60

tttgggcggg gtccagttcc                                                   80


<210> 390
<211> 79
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide

<400> 390
tttggtcggc atggccccat tcgcacggct ctggagcggc ggcgaggcaa gagggcggct       60

ttgggcgggg tccagttcc                                                    79


<210> 391
<211> 78
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide

<400> 391
tttggtcggc atggccccat tcgcacggct ctggagcggc ggctggcaag agggcggctt       60

tgggcggggt ccagttcc                                                     78


<210> 392
<211> 77
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide

<400> 392
tttggtcggc atggccccat tcgcacggct ctggagcggc ggcggcaaga gggcggcttt       60

gggcggggtc cagttcc                                                      77


<210> 393
<211> 74
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide

<400> 393
tttggtcggc atggccccat tcgcacggct ctggagtgga ggcaagaggg cggctttggg       60

cggggtccag ttcc                                                         74


<210> 394
<211> 69
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide

<400> 394
tttggtcggc atggccccat tcgcacggct ctggaggcaa gagggcggct ttgggcgggg       60

tccagttcc                                                               69


<210> 395
<211> 26
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide

<400> 395
tttggtcggc atggccccgt cactgt                                            26


<210> 396
<211> 260
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      polynucleotide

<400> 396
tttggtcggc atggccccat tcgcacggct ctggagcggc ggcacactat tgcaatgaaa       60

ataaatttcc tttattagct agaagtgaga tctgaagggg cttcatgatg tccccataat      120

ttttggcaga gggaaaaaga tctcagtggt atttgtgagc cagggcattg gccacaccag      180

ccaccacctt ttgataggca gcctgcacct gaggagtgcg agtggaggca agagggcggc      240

tttgggcggg gtccagttcc                                                  260


<210> 397
<211> 92
<212> DNA
<213> Homo sapiens

<400> 397
gttcaactcg atgaccccac caccaatcag tagctatggc gagccctgct gtctccggcc       60

cctccccagt cagggggccc ccagtgtggg ga                                     92


<210> 398
<211> 85
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide

<400> 398
gttcaactcg atgaccccac caccaatcag tagctatcct gctgtctccg gcccctcccc       60

agtcaggggg cccccagtgt gggga                                             85


<210> 399
<211> 79
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide

<400> 399
gttcaactcg atgaccccac caccaatcag tagctatgtc tccggcccct ccccagtcag       60

ggggccccca gtgtgggga                                                    79


<210> 400
<211> 75
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide

<400> 400
gttcaactcg atgaccccac caccaatcag tagctatggc gagccccccc agtcaggggg       60

cccccagtgt gggga                                                        75


<210> 401
<211> 74
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide

<400> 401
gttcaactcg atgaccccac caccaacctg ctgtctccgg cccctcccca gtcagggggc       60

ccccagtgtg ggga                                                         74


<210> 402
<211> 92
<212> DNA
<213> Homo sapiens

<400> 402
tggctgaagg cacttccgtt gagcatctag acgtttcctt ggctcttctg gcgccaaaat       60

gtcgttcgtg gcaggggtta ttcggcggct gg                                     92


<210> 403
<211> 83
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide

<400> 403
tggctgaagg cacttccgtt gagcatctag acgtttcctt ggcgccaaaa tgtcgttcgt       60

ggcaggggtt attcggcggc tgg                                               83


<210> 404
<211> 76
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide

<400> 404
tggctgaagg cacttccgtt gagcatctat tctggcgcca aaatgtcgtt cgtggcaggg       60

gttattcggc ggctgg                                                       76


<210> 405
<211> 76
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide

<400> 405
tggctgaagg cacttccgtt gagcatctag acgtttcctt ggatgtcgtt cgtggcaggg       60

gttattcggc ggctgg                                                       76


<210> 406
<211> 68
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide

<400> 406
tggctgaagg cacttccgtt gagcatctag acgtttgtcg ttcgtggcag gggttattcg       60

gcggctgg                                                                68


<210> 407
<211> 92
<212> DNA
<213> Homo sapiens

<400> 407
cccttctgac tgtggccgct tggcatggcc agcaacagca gctcctgccc gacacctggg       60

ggcgggcacc tcaatgggta cccggtgcct cc                                     92


<210> 408
<211> 86
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide

<400> 408
cccttctgac tgtggccgct tggcatggcc agcaacacct gcccgacacc tgggggcggg       60

cacctcaatg ggtacccggt gcctcc                                            86


<210> 409
<211> 85
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide

<400> 409
cccttctgac tgtggccgct tggcatggcc agcaacactg cccgacacct gggggcgggc       60

acctcaatgg gtacccggtg cctcc                                             85


<210> 410
<211> 80
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide

<400> 410
cccttctgac tgtggccgct tggcatggcc agcagcccga cacctggggg cgggcacctc       60

aatgggtacc cggtgcctcc                                                   80


<210> 411
<211> 78
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide

<400> 411
cccttctgac tgtggccgct tggcatggcc aggcccgaca cctgggggcg ggcacctcaa       60

tgggtacccg gtgcctcc                                                     78


<210> 412
<211> 92
<212> DNA
<213> Homo sapiens

<400> 412
tcagaaatag ggggtccagg agcaaactcc ccccaccccc tttccaaagc ccattccctc       60

tttagccaga gccggggtgt gcagacggca gt                                     92


<210> 413
<211> 92
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide

<400> 413
tcagaaatag ggggtccagg agcaaactcc ccccaccccc tttccaaaaa gcccattccc       60

tctttagcca gagccggggt gtgcagacgg ca                                     92


<210> 414
<211> 89
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide

<400> 414
tcagaaatag ggggtccagg agcaaactcc ccccaccccc tttccgccca ttccctcttt       60

agccagagcc ggggtgtgca gacggcagt                                         89


<210> 415
<211> 87
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide

<400> 415
tcagaaatag ggggtccagg agcaaactcc ccccaccccc ttagcccatt ccctctttag       60

ccagagccgg ggtgtgcaga cggcagt                                           87


<210> 416
<211> 87
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide

<400> 416
tcagaaatag ggggtccagg agcaaactcc ccccaccccc aaagcccatt ccctctttag       60

ccagagccgg ggtgtgcaga cggcagt                                           87


<210> 417
<211> 86
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide

<400> 417
tcagaaatag ggggtccagg agcaaactcc ccccacccca aagcccattc cctctttagc       60

cagagccggg gtgtgcagac ggcagt                                            86


<210> 418
<211> 85
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide

<400> 418
tcagaaatag ggggtccagg agcaaactcc ccccaccccc tttccattcc ctctttagcc       60

agagccgggg tgtgcagacg gcagt                                             85


<210> 419
<211> 84
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide

<400> 419
tcagaaatag ggggtccagg agcaaactcc ccccaccccc tttcattccc tctttagcca       60

gagccggggt gtgcagacgg cagt                                              84


<210> 420
<211> 83
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide

<400> 420
tcagaaatag ggggtccagg agcaaactcc ccccacaaag cccattccct ctttagccag       60

agccggggtg tgcagacggc agt                                               83


<210> 421
<211> 78
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide

<400> 421
tcagaaatag ggggtccagg agcaaactcc ccccacccat tccctcttta gccagagccg       60

gggtgtgcag acggcagt                                                     78


<210> 422
<211> 75
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide

<400> 422
tcagaaatag ggggtccagg agcaaaccaa agcccattcc ctctttagcc agagccgggg       60

tgtgcagacg gcagt                                                        75


<210> 423
<211> 74
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide

<400> 423
tcagaaatag ggggtccagg agcaaactcc ccccaccccc tctttagcca gagccggggt       60

gtgcagacgg cagt                                                         74


<210> 424
<211> 72
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide

<400> 424
tcagaaatag ggggtccagg agcaaactcc ccccaccccc tttagccaga gccggggtgt       60

gcagacggca gt                                                           72


<210> 425
<211> 68
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide

<400> 425
tcagaaatag ggggtccagg caaagcccat tccctcttta gccagagccg gggtgtgcag       60

acggcagt                                                                68


<210> 426
<211> 57
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide

<400> 426
tcagaaatag ggggtccagg agctctttag ccagagccgg ggtgtgcaga cggcagt          57


<210> 427
<211> 92
<212> DNA
<213> Homo sapiens

<400> 427
ccccagcccc agctaccacc tcctccccgg ccggcggcgg acagtggacg cggcggcgag       60

ccgcgggcag gggccggagc ccgcgcccgg ag                                     92


<210> 428
<211> 84
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide

<400> 428
ccccagcccc agctaccacc tcctccccgg ccggcgtgga cgcggcggcg agccgcgggc       60

aggggccgga gcccgcgccc ggag                                              84


<210> 429
<211> 79
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide

<400> 429
ccccagcccc agctaccacc tcctccccgg ccggacgcgg cggcgagccg cgggcagggg       60

ccggagcccg cgcccggag                                                    79


<210> 430
<211> 79
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide

<400> 430
ccccagcccc agctaccacc tcctccccgg ctggacgcgg cggcgagccg cgggcagggg       60

ccggagcccg cgcccggag                                                    79


<210> 431
<211> 76
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide

<400> 431
ccccagcccc agctaccacc tcctccccgg ccggcggcgg acagccgcgg gcaggggccg       60

gagcccgcgc ccggag                                                       76


<210> 432
<211> 75
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide

<400> 432
ccccagcccc agctaccacc tcctccccgg acgcggcggc gagccgcggg caggggccgg       60

agcccgcgcc cggag                                                        75


<210> 433
<211> 49
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide

<400> 433
ccccagcccc agctaccacc tcctccccgg ccggagcccg cgcccgaag                   49


<210> 434
<211> 63
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide

<400> 434
ccccagcccc agctaccacc tcctccccgg ccggcggcgg acagtggagg gggtcggggc       60

tcg                                                                     63


<210> 435
<211> 36
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide

<400> 435
ccccagcccc agctaccacc tcctccccgg ccggag                                 36


<210> 436
<211> 55
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide

<400> 436
ccccagcccc agctaccacc tcctccccgg ccggcggcgg ggtggagggg gtcgg            55


<210> 437
<211> 60
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide

<400> 437
ccccagcccc agctaccacc tcctccccgg ccggcggcgg acacacacgc ggcgtcgcac       60


<210> 438
<211> 53
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide

<400> 438
ccccagcccc agctaccacc tcctccccgg ccggcggcct gaaacttttc gtc              53


<210> 439
<211> 30
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide

<400> 439
ccggagcgcg gcgtggaggg ggtcggggct                                        30


<210> 440
<211> 92
<212> DNA
<213> Homo sapiens

<400> 440
ccattccctc tttagccaga gccggggtgt gcagacggca gtcactaggg ggcgctcggc       60

caccacaggg aagctgggtg aatggagcga gc                                     92


<210> 441
<211> 89
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide

<400> 441
ccattccctc tttagccaga gccggggtgt gcagacggca cttagggggc gctcggccac       60

cacagggaag ctgggtgaat ggagcgagc                                         89


<210> 442
<211> 88
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide

<400> 442
ccattccctc tttagccaga gccggggtgt gcagacggca ctagggggcg ctcggccacc       60

acagggaagc tgggtgaatg gagcgagc                                          88


<210> 443
<211> 87
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide

<400> 443
ccattccctc tttagccaga gccggggtgt gcagacggca gtcagggcgc tcggccacca       60

cagggaagct gggtgaatgg agcgagc                                           87


<210> 444
<211> 87
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide

<400> 444
ccattccctc tttagccaga gccggggtgt gcagacggca tagggggcgc tcggccacca       60

cagggaagct gggtgaatgg agcgagc                                           87


<210> 445
<211> 84
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide

<400> 445
ccattccctc tttagccaga gccggggtgt gcagacctag ggggcgctcg gccaccacag       60

ggaagctggg tgaatggagc gagc                                              84


<210> 446
<211> 83
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide

<400> 446
ccattccctc tttagccaga gccggggtgt gcagacggca gggcgctcgg ccaccacagg       60

gaagctgggt gaatggagcg agc                                               83


<210> 447
<211> 83
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide

<400> 447
ccattccctc tttagccaga gccggggtgt gcagactagg gggcgctcgg ccaccacagg       60

gaagctgggt gaatggagcg agc                                               83


<210> 448
<211> 82
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide

<400> 448
ccattccctc tttagccaga gccggggtgt gcagctaggg ggcgctcggc caccacaggg       60

aagctgggtg aatggagcga gc                                                82


<210> 449
<211> 81
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide

<400> 449
ccattccctc tttagccaga gccggggtgt gcagaagggg gcgctcggcc accacaggga       60

agctgggtga atggagcgag c                                                 81


<210> 450
<211> 81
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide

<400> 450
ccattccctc tttagccaga gccggggtgt gcactagggg gcgctcggcc accacaggga       60

agctgggtga atggagcgag c                                                 81


<210> 451
<211> 79
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide

<400> 451
ccattccctc tttagccaga gccggggtgt gcagacggca gttcggccac cacagggaag       60

ctgggtgaat ggagcgagc                                                    79


<210> 452
<211> 78
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide

<400> 452
ccattccctc tttagccaga gccggggtgt ctagggggcg ctcggccacc acagggaagc       60

tgggtgaatg gagcgagc                                                     78


<210> 453
<211> 77
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide

<400> 453
ccattccctc tttagccaga gccggggtgt gcaggggcgc tcggccacca cagggaagct       60

gggtgaatgg agcgagc                                                      77


<210> 454
<211> 76
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide

<400> 454
ccattccctc tttagccaga gccggggtgt gcagggcgct cggccaccac agggaagctg       60

ggtgaatgga gcgagc                                                       76


<210> 455
<211> 76
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide

<400> 455
ccattccctc tttagccaga gccggggtgt gcagacggca gtcactacac agggaagctg       60

ggtgaatgga gcgagc                                                       76


<210> 456
<211> 76
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide

<400> 456
ccattccctc tttagccaga gccggggtgt gcagacggct cggccaccac agggaagctg       60

ggtgaatgga gcgagc                                                       76


<210> 457
<211> 75
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide

<400> 457
ccattccctc tttagccaga gccggggtgt gcagacgctc ggccaccaca gggaagctgg       60

gtgaatggag cgagc                                                        75


<210> 458
<211> 73
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide

<400> 458
ccattccctc tttagccaga gccggggtgg gggcgctcgg ccaccacagg gaagctgggt       60

gaatggagcg agc                                                          73


<210> 459
<211> 71
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide

<400> 459
ccattccctc tttagccaga gccggggtgt gcgctcggcc accacaggga agctgggtga       60

atggagcgag c                                                            71


<210> 460
<211> 71
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide

<400> 460
ccattccctc tttagccaga gccggggtgt gcagacggca gtcacaggga agctgggtga       60

atggagcgag c                                                            71


<210> 461
<211> 71
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide

<400> 461
ccattccctc tttagccaga gccggggtgt gcagacggcc accacaggga agctgggtga       60

atggagcgag c                                                            71


<210> 462
<211> 69
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide

<400> 462
ccattccctc tttagccaga gccggggtgt gcagacggca gtcagggaag ctgggtgaat       60

ggagcgagc                                                               69


<210> 463
<211> 68
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide

<400> 463
ccattccctc tttagccaga gccggggtgt gcaggccacc acagggaagc tgggtgaatg       60

gagcgagc                                                                68


<210> 464
<211> 68
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide

<400> 464
ccattccctc tttagccaga gccggggtgt gcagaccacc acagggaagc tgggtgaatg       60

gagcgagc                                                                68


<210> 465
<211> 65
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide

<400> 465
ccattccctc tttagccaga gccggggtgt gcagaccaca gggaagctgg gtgaatggag       60

cgagc                                                                   65


<210> 466
<211> 58
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide

<400> 466
ccattccctc ttagtgactg ctcggccacc acagggaagc tgggtgaatg gagcgagc         58



