                         SEQUENCE LISTING

<110>  LFB et al
 
<120>  FACTEUR X DEPOURVU DE DOMAINE GLA

<130>  BFF130101

<160>  93    

<170>  PatentIn version 3.5

<210>  1
<211>  306
<212>  PRT
<213>  Homo sapiens

<400>  1

Ser Val Ala Gln Ala Thr Ser Ser Ser Gly Glu Ala Pro Asp Ser Ile 
1               5                   10                  15      


Thr Trp Lys Pro Tyr Asp Ala Ala Asp Leu Asp Pro Thr Glu Asn Pro 
            20                  25                  30          


Phe Asp Leu Leu Asp Phe Asn Gln Thr Gln Pro Glu Arg Gly Asp Asn 
        35                  40                  45              


Asn Leu Thr Arg Ile Val Gly Gly Gln Glu Cys Lys Asp Gly Glu Cys 
    50                  55                  60                  


Pro Trp Gln Ala Leu Leu Ile Asn Glu Glu Asn Glu Gly Phe Cys Gly 
65                  70                  75                  80  


Gly Thr Ile Leu Ser Glu Phe Tyr Ile Leu Thr Ala Ala His Cys Leu 
                85                  90                  95      


Tyr Gln Ala Lys Arg Phe Lys Val Arg Val Gly Asp Arg Asn Thr Glu 
            100                 105                 110         


Gln Glu Glu Gly Gly Glu Ala Val His Glu Val Glu Val Val Ile Lys 
        115                 120                 125             


His Asn Arg Phe Thr Lys Glu Thr Tyr Asp Phe Asp Ile Ala Val Leu 
    130                 135                 140                 


Arg Leu Lys Thr Pro Ile Thr Phe Arg Met Asn Val Ala Pro Ala Cys 
145                 150                 155                 160 


Leu Pro Glu Arg Asp Trp Ala Glu Ser Thr Leu Met Thr Gln Lys Thr 
                165                 170                 175     


Gly Ile Val Ser Gly Phe Gly Arg Thr His Glu Lys Gly Arg Gln Ser 
            180                 185                 190         


Thr Arg Leu Lys Met Leu Glu Val Pro Tyr Val Asp Arg Asn Ser Cys 
        195                 200                 205             


Lys Leu Ser Ser Ser Phe Ile Ile Thr Gln Asn Met Phe Cys Ala Gly 
    210                 215                 220                 


Tyr Asp Thr Lys Gln Glu Asp Ala Cys Gln Gly Asp Ser Gly Gly Pro 
225                 230                 235                 240 


His Val Thr Arg Phe Lys Asp Thr Tyr Phe Val Thr Gly Ile Val Ser 
                245                 250                 255     


Trp Gly Glu Gly Cys Ala Arg Lys Gly Lys Tyr Gly Ile Tyr Thr Lys 
            260                 265                 270         


Val Thr Ala Phe Leu Lys Trp Ile Asp Arg Ser Met Lys Thr Arg Gly 
        275                 280                 285             


Leu Pro Lys Ala Lys Ser His Ala Pro Glu Val Ile Thr Ser Ser Pro 
    290                 295                 300                 


Leu Lys 
305     


<210>  2
<211>  182
<212>  PRT
<213>  Homo sapiens

<400>  2

Met Gly Arg Pro Leu His Leu Val Leu Leu Ser Ala Ser Leu Ala Gly 
1               5                   10                  15      


Leu Leu Leu Leu Gly Glu Ser Leu Phe Ile Arg Arg Glu Gln Ala Asn 
            20                  25                  30          


Asn Ile Leu Ala Arg Val Thr Arg Ala Asn Ser Phe Leu Glu Glu Met 
        35                  40                  45              


Lys Lys Gly His Leu Glu Arg Glu Cys Met Glu Glu Thr Cys Ser Tyr 
    50                  55                  60                  


Glu Glu Ala Arg Glu Val Phe Glu Asp Ser Asp Lys Thr Asn Glu Phe 
65                  70                  75                  80  


Trp Asn Lys Tyr Lys Asp Gly Asp Gln Cys Glu Thr Ser Pro Cys Gln 
                85                  90                  95      


Asn Gln Gly Lys Cys Lys Asp Gly Leu Gly Glu Tyr Thr Cys Thr Cys 
            100                 105                 110         


Leu Glu Gly Phe Glu Gly Lys Asn Cys Glu Leu Phe Thr Arg Lys Leu 
        115                 120                 125             


Cys Ser Leu Asp Asn Gly Asp Cys Asp Gln Phe Cys His Glu Glu Gln 
    130                 135                 140                 


Asn Ser Val Val Cys Ser Cys Ala Arg Gly Tyr Thr Leu Ala Asp Asn 
145                 150                 155                 160 


Gly Lys Ala Cys Ile Pro Thr Gly Pro Tyr Pro Cys Gly Lys Gln Thr 
                165                 170                 175     


Leu Glu Arg Arg Lys Arg 
            180         


<210>  3
<211>  52
<212>  PRT
<213>  Homo sapiens

<400>  3

Ser Val Ala Gln Ala Thr Ser Ser Ser Gly Glu Ala Pro Asp Ser Ile 
1               5                   10                  15      


Thr Trp Lys Pro Tyr Asp Ala Ala Asp Leu Asp Pro Thr Glu Asn Pro 
            20                  25                  30          


Phe Asp Leu Leu Asp Phe Asn Gln Thr Gln Pro Glu Arg Gly Asp Asn 
        35                  40                  45              


Asn Leu Thr Arg 
    50          


<210>  4
<211>  488
<212>  PRT
<213>  Homo sapiens

<400>  4

Met Gly Arg Pro Leu His Leu Val Leu Leu Ser Ala Ser Leu Ala Gly 
1               5                   10                  15      


Leu Leu Leu Leu Gly Glu Ser Leu Phe Ile Arg Arg Glu Gln Ala Asn 
            20                  25                  30          


Asn Ile Leu Ala Arg Val Thr Arg Ala Asn Ser Phe Leu Glu Glu Met 
        35                  40                  45              


Lys Lys Gly His Leu Glu Arg Glu Cys Met Glu Glu Thr Cys Ser Tyr 
    50                  55                  60                  


Glu Glu Ala Arg Glu Val Phe Glu Asp Ser Asp Lys Thr Asn Glu Phe 
65                  70                  75                  80  


Trp Asn Lys Tyr Lys Asp Gly Asp Gln Cys Glu Thr Ser Pro Cys Gln 
                85                  90                  95      


Asn Gln Gly Lys Cys Lys Asp Gly Leu Gly Glu Tyr Thr Cys Thr Cys 
            100                 105                 110         


Leu Glu Gly Phe Glu Gly Lys Asn Cys Glu Leu Phe Thr Arg Lys Leu 
        115                 120                 125             


Cys Ser Leu Asp Asn Gly Asp Cys Asp Gln Phe Cys His Glu Glu Gln 
    130                 135                 140                 


Asn Ser Val Val Cys Ser Cys Ala Arg Gly Tyr Thr Leu Ala Asp Asn 
145                 150                 155                 160 


Gly Lys Ala Cys Ile Pro Thr Gly Pro Tyr Pro Cys Gly Lys Gln Thr 
                165                 170                 175     


Leu Glu Arg Arg Lys Arg Ser Val Ala Gln Ala Thr Ser Ser Ser Gly 
            180                 185                 190         


Glu Ala Pro Asp Ser Ile Thr Trp Lys Pro Tyr Asp Ala Ala Asp Leu 
        195                 200                 205             


Asp Pro Thr Glu Asn Pro Phe Asp Leu Leu Asp Phe Asn Gln Thr Gln 
    210                 215                 220                 


Pro Glu Arg Gly Asp Asn Asn Leu Thr Arg Ile Val Gly Gly Gln Glu 
225                 230                 235                 240 


Cys Lys Asp Gly Glu Cys Pro Trp Gln Ala Leu Leu Ile Asn Glu Glu 
                245                 250                 255     


Asn Glu Gly Phe Cys Gly Gly Thr Ile Leu Ser Glu Phe Tyr Ile Leu 
            260                 265                 270         


Thr Ala Ala His Cys Leu Tyr Gln Ala Lys Arg Phe Lys Val Arg Val 
        275                 280                 285             


Gly Asp Arg Asn Thr Glu Gln Glu Glu Gly Gly Glu Ala Val His Glu 
    290                 295                 300                 


Val Glu Val Val Ile Lys His Asn Arg Phe Thr Lys Glu Thr Tyr Asp 
305                 310                 315                 320 


Phe Asp Ile Ala Val Leu Arg Leu Lys Thr Pro Ile Thr Phe Arg Met 
                325                 330                 335     


Asn Val Ala Pro Ala Cys Leu Pro Glu Arg Asp Trp Ala Glu Ser Thr 
            340                 345                 350         


Leu Met Thr Gln Lys Thr Gly Ile Val Ser Gly Phe Gly Arg Thr His 
        355                 360                 365             


Glu Lys Gly Arg Gln Ser Thr Arg Leu Lys Met Leu Glu Val Pro Tyr 
    370                 375                 380                 


Val Asp Arg Asn Ser Cys Lys Leu Ser Ser Ser Phe Ile Ile Thr Gln 
385                 390                 395                 400 


Asn Met Phe Cys Ala Gly Tyr Asp Thr Lys Gln Glu Asp Ala Cys Gln 
                405                 410                 415     


Gly Asp Ser Gly Gly Pro His Val Thr Arg Phe Lys Asp Thr Tyr Phe 
            420                 425                 430         


Val Thr Gly Ile Val Ser Trp Gly Glu Gly Cys Ala Arg Lys Gly Lys 
        435                 440                 445             


Tyr Gly Ile Tyr Thr Lys Val Thr Ala Phe Leu Lys Trp Ile Asp Arg 
    450                 455                 460                 


Ser Met Lys Thr Arg Gly Leu Pro Lys Ala Lys Ser His Ala Pro Glu 
465                 470                 475                 480 


Val Ile Thr Ser Ser Pro Leu Lys 
                485             


<210>  5
<211>  142
<212>  PRT
<213>  Homo sapiens

<400>  5

Ala Asn Ser Phe Leu Glu Glu Met Lys Lys Gly His Leu Glu Arg Glu 
1               5                   10                  15      


Cys Met Glu Glu Thr Cys Ser Tyr Glu Glu Ala Arg Glu Val Phe Glu 
            20                  25                  30          


Asp Ser Asp Lys Thr Asn Glu Phe Trp Asn Lys Tyr Lys Asp Gly Asp 
        35                  40                  45              


Gln Cys Glu Thr Ser Pro Cys Gln Asn Gln Gly Lys Cys Lys Asp Gly 
    50                  55                  60                  


Leu Gly Glu Tyr Thr Cys Thr Cys Leu Glu Gly Phe Glu Gly Lys Asn 
65                  70                  75                  80  


Cys Glu Leu Phe Thr Arg Lys Leu Cys Ser Leu Asp Asn Gly Asp Cys 
                85                  90                  95      


Asp Gln Phe Cys His Glu Glu Gln Asn Ser Val Val Cys Ser Cys Ala 
            100                 105                 110         


Arg Gly Tyr Thr Leu Ala Asp Asn Gly Lys Ala Cys Ile Pro Thr Gly 
        115                 120                 125             


Pro Tyr Pro Cys Gly Lys Gln Thr Leu Glu Arg Arg Lys Arg 
    130                 135                 140         


<210>  6
<211>  254
<212>  PRT
<213>  Homo sapiens

<400>  6

Ile Val Gly Gly Gln Glu Cys Lys Asp Gly Glu Cys Pro Trp Gln Ala 
1               5                   10                  15      


Leu Leu Ile Asn Glu Glu Asn Glu Gly Phe Cys Gly Gly Thr Ile Leu 
            20                  25                  30          


Ser Glu Phe Tyr Ile Leu Thr Ala Ala His Cys Leu Tyr Gln Ala Lys 
        35                  40                  45              


Arg Phe Lys Val Arg Val Gly Asp Arg Asn Thr Glu Gln Glu Glu Gly 
    50                  55                  60                  


Gly Glu Ala Val His Glu Val Glu Val Val Ile Lys His Asn Arg Phe 
65                  70                  75                  80  


Thr Lys Glu Thr Tyr Asp Phe Asp Ile Ala Val Leu Arg Leu Lys Thr 
                85                  90                  95      


Pro Ile Thr Phe Arg Met Asn Val Ala Pro Ala Cys Leu Pro Glu Arg 
            100                 105                 110         


Asp Trp Ala Glu Ser Thr Leu Met Thr Gln Lys Thr Gly Ile Val Ser 
        115                 120                 125             


Gly Phe Gly Arg Thr His Glu Lys Gly Arg Gln Ser Thr Arg Leu Lys 
    130                 135                 140                 


Met Leu Glu Val Pro Tyr Val Asp Arg Asn Ser Cys Lys Leu Ser Ser 
145                 150                 155                 160 


Ser Phe Ile Ile Thr Gln Asn Met Phe Cys Ala Gly Tyr Asp Thr Lys 
                165                 170                 175     


Gln Glu Asp Ala Cys Gln Gly Asp Ser Gly Gly Pro His Val Thr Arg 
            180                 185                 190         


Phe Lys Asp Thr Tyr Phe Val Thr Gly Ile Val Ser Trp Gly Glu Gly 
        195                 200                 205             


Cys Ala Arg Lys Gly Lys Tyr Gly Ile Tyr Thr Lys Val Thr Ala Phe 
    210                 215                 220                 


Leu Lys Trp Ile Asp Arg Ser Met Lys Thr Arg Gly Leu Pro Lys Ala 
225                 230                 235                 240 


Lys Ser His Ala Pro Glu Val Ile Thr Ser Ser Pro Leu Lys 
                245                 250                 


<210>  7
<211>  357
<212>  PRT
<213>  Homo sapiens

<400>  7

Lys Tyr Lys Asp Gly Asp Gln Cys Glu Thr Ser Pro Cys Gln Asn Gln 
1               5                   10                  15      


Gly Lys Cys Lys Asp Gly Leu Gly Glu Tyr Thr Cys Thr Cys Leu Glu 
            20                  25                  30          


Gly Phe Glu Gly Lys Asn Cys Glu Leu Phe Thr Arg Lys Leu Cys Ser 
        35                  40                  45              


Leu Asp Asn Gly Asp Cys Asp Gln Phe Cys His Glu Glu Gln Asn Ser 
    50                  55                  60                  


Val Val Cys Ser Cys Ala Arg Gly Tyr Thr Leu Ala Asp Asn Gly Lys 
65                  70                  75                  80  


Ala Cys Ile Pro Thr Gly Pro Tyr Pro Cys Gly Lys Gln Thr Leu Glu 
                85                  90                  95      


Arg Arg Lys Arg Arg Lys Arg Ile Val Gly Gly Gln Glu Cys Lys Asp 
            100                 105                 110         


Gly Glu Cys Pro Trp Gln Ala Leu Leu Ile Asn Glu Glu Asn Glu Gly 
        115                 120                 125             


Phe Cys Gly Gly Thr Ile Leu Ser Glu Phe Tyr Ile Leu Thr Ala Ala 
    130                 135                 140                 


His Cys Leu Tyr Gln Ala Lys Arg Phe Lys Val Arg Val Gly Asp Arg 
145                 150                 155                 160 


Asn Thr Glu Gln Glu Glu Gly Gly Glu Ala Val His Glu Val Glu Val 
                165                 170                 175     


Val Ile Lys His Asn Arg Phe Thr Lys Glu Thr Tyr Asp Phe Asp Ile 
            180                 185                 190         


Ala Val Leu Arg Leu Lys Thr Pro Ile Thr Phe Arg Met Asn Val Ala 
        195                 200                 205             


Pro Ala Cys Leu Pro Glu Arg Asp Trp Ala Glu Ser Thr Leu Met Thr 
    210                 215                 220                 


Gln Lys Thr Gly Ile Val Ser Gly Phe Gly Arg Thr His Glu Lys Gly 
225                 230                 235                 240 


Arg Gln Ser Thr Arg Leu Lys Met Leu Glu Val Pro Tyr Val Asp Arg 
                245                 250                 255     


Asn Ser Cys Lys Leu Ser Ser Ser Phe Ile Ile Thr Gln Asn Met Phe 
            260                 265                 270         


Cys Ala Gly Tyr Asp Thr Lys Gln Glu Asp Ala Cys Gln Gly Asp Ser 
        275                 280                 285             


Gly Gly Pro His Val Thr Arg Phe Lys Asp Thr Tyr Phe Val Thr Gly 
    290                 295                 300                 


Ile Val Ser Trp Gly Glu Gly Cys Ala Arg Lys Gly Lys Tyr Gly Ile 
305                 310                 315                 320 


Tyr Thr Lys Val Thr Ala Phe Leu Lys Trp Ile Asp Arg Ser Met Lys 
                325                 330                 335     


Thr Arg Gly Leu Pro Lys Ala Lys Ser His Ala Pro Glu Val Ile Thr 
            340                 345                 350         


Ser Ser Pro Leu Lys 
        355         


<210>  8
<211>  1071
<212>  DNA
<213>  Homo sapiens

<400>  8
aaatacaaag atggcgacca gtgtgagacc agtccttgcc agaaccaggg caaatgtaaa       60

gacggcctcg gggaatacac ctgcacctgt ttagaaggat tcgaaggcaa aaactgtgaa      120

ttattcacac ggaagctctg cagcctggac aacggggact gtgaccagtt ctgccacgag      180

gaacagaact ctgtggtgtg ctcctgcgcc cgcgggtaca ccctggctga caacggcaag      240

gcctgcattc ccacagggcc ctacccctgt gggaaacaga ccctggaacg caggaagagg      300

aggaagagga tcgtgggagg ccaggaatgc aaggacgggg agtgtccctg gcaggccctg      360

ctcatcaatg aggaaaacga gggtttctgt ggtggaacca ttctgagcga gttctacatc      420

ctaacggcag cccactgtct ctaccaagcc aagagattca aggtgagggt aggggaccgg      480

aacacggagc aggaggaggg cggtgaggcg gtgcacgagg tggaggtggt catcaagcac      540

aaccggttca caaaggagac ctatgacttc gacatcgccg tgctccggct caaggaagac      600

caggtggacc caagactgat tgacggaaaa tgagaattcg gatcccccga cctcgagtcc      660

acgctgatga cgcagaagac ggggattgtg agcggcttcg ggcgcaccca cgagaagggc      720

cggcagtcca ccaggctcaa gatgctggag gtgccctacg tggaccgcaa cagctgcaag      780

ctgtccagca gcttcatcat cacccagaac atgttctgtg ccggctacga caccaagcag      840

gaggatgcct gccaggggga cagcgggggc ccgcacgtca cccgcttcaa ggacacctac      900

ttcgtgacag gcatcgtcag ctggggagag ggctgtgccc gtaaggggaa gtacgggatc      960

tacaccaagg tcaccgcctt cctcaagtgg atcgacaggt ccatgaaaac caggggcttg     1020

cccaaggcca agagccatgc cccggaggtc ataacgtcct ctccattaaa g              1071


<210>  9
<211>  354
<212>  PRT
<213>  Homo sapiens

<400>  9

Lys Tyr Lys Asp Gly Asp Gln Cys Glu Thr Ser Pro Cys Gln Asn Gln 
1               5                   10                  15      


Gly Lys Cys Lys Asp Gly Leu Gly Glu Tyr Thr Cys Thr Cys Leu Glu 
            20                  25                  30          


Gly Phe Glu Gly Lys Asn Cys Glu Leu Phe Thr Arg Lys Leu Cys Ser 
        35                  40                  45              


Leu Asp Asn Gly Asp Cys Asp Gln Phe Cys His Glu Glu Gln Asn Ser 
    50                  55                  60                  


Val Val Cys Ser Cys Ala Arg Gly Tyr Thr Leu Ala Asp Asn Gly Lys 
65                  70                  75                  80  


Ala Cys Ile Pro Thr Gly Pro Tyr Pro Cys Gly Lys Gln Thr Leu Glu 
                85                  90                  95      


Arg Arg Lys Arg Ile Val Gly Gly Gln Glu Cys Lys Asp Gly Glu Cys 
            100                 105                 110         


Pro Trp Gln Ala Leu Leu Ile Asn Glu Glu Asn Glu Gly Phe Cys Gly 
        115                 120                 125             


Gly Thr Ile Leu Ser Glu Phe Tyr Ile Leu Thr Ala Ala His Cys Leu 
    130                 135                 140                 


Tyr Gln Ala Lys Arg Phe Lys Val Arg Val Gly Asp Arg Asn Thr Glu 
145                 150                 155                 160 


Gln Glu Glu Gly Gly Glu Ala Val His Glu Val Glu Val Val Ile Lys 
                165                 170                 175     


His Asn Arg Phe Thr Lys Glu Thr Tyr Asp Phe Asp Ile Ala Val Leu 
            180                 185                 190         


Arg Leu Lys Thr Pro Ile Thr Phe Arg Met Asn Val Ala Pro Ala Cys 
        195                 200                 205             


Leu Pro Glu Arg Asp Trp Ala Glu Ser Thr Leu Met Thr Gln Lys Thr 
    210                 215                 220                 


Gly Ile Val Ser Gly Phe Gly Arg Thr His Glu Lys Gly Arg Gln Ser 
225                 230                 235                 240 


Thr Arg Leu Lys Met Leu Glu Val Pro Tyr Val Asp Arg Asn Ser Cys 
                245                 250                 255     


Lys Leu Ser Ser Ser Phe Ile Ile Thr Gln Asn Met Phe Cys Ala Gly 
            260                 265                 270         


Tyr Asp Thr Lys Gln Glu Asp Ala Cys Gln Gly Asp Ser Gly Gly Pro 
        275                 280                 285             


His Val Thr Arg Phe Lys Asp Thr Tyr Phe Val Thr Gly Ile Val Ser 
    290                 295                 300                 


Trp Gly Glu Gly Cys Ala Arg Lys Gly Lys Tyr Gly Ile Tyr Thr Lys 
305                 310                 315                 320 


Val Thr Ala Phe Leu Lys Trp Ile Asp Arg Ser Met Lys Thr Arg Gly 
                325                 330                 335     


Leu Pro Lys Ala Lys Ser His Ala Pro Glu Val Ile Thr Ser Ser Pro 
            340                 345                 350         


Leu Lys 
        


<210>  10
<211>  1062
<212>  DNA
<213>  Homo sapiens

<400>  10
aaatacaaag atggcgacca gtgtgagacc agtccttgcc agaaccaggg caaatgtaaa       60

gacggcctcg gggaatacac ctgcacctgt ttagaaggat tcgaaggcaa aaactgtgaa      120

ttattcacac ggaagctctg cagcctggac aacggggact gtgaccagtt ctgccacgag      180

gaacagaact ctgtggtgtg ctcctgcgcc cgcgggtaca ccctggctga caacggcaag      240

gcctgcattc ccacagggcc ctacccctgt gggaaacaga ccctggaacg caggaagagg      300

atcgtgggag gccaggaatg caaggacggg gagtgtccct ggcaggccct gctcatcaat      360

gaggaaaacg agggtttctg tggtggaacc attctgagcg agttctacat cctaacggca      420

gcccactgtc tctaccaagc caagagattc aaggtgaggg taggggaccg gaacacggag      480

caggaggagg gcggtgaggc ggtgcacgag gtggaggtgg tcatcaagca caaccggttc      540

acaaaggaga cctatgactt cgacatcgcc gtgctccggc tcaagacccc catcaccttc      600

cgcatgaacg tggcgcctgc ctgcctcccc gagcgtgact gggccgagtc cacgctgatg      660

acgcagaaga cggggattgt gagcggcttc gggcgcaccc acgagaaggg ccggcagtcc      720

accaggctca agatgctgga ggtgccctac gtggaccgca acagctgcaa gctgtccagc      780

agcttcatca tcacccagaa catgttctgt gccggctacg acaccaagca ggaggatgcc      840

tgccaggggg acagcggggg cccgcacgtc acccgcttca aggacaccta cttcgtgaca      900

ggcatcgtca gctggggaga gggctgtgcc cgtaagggga agtacgggat ctacaccaag      960

gtcaccgcct tcctcaagtg gatcgacagg tccatgaaaa ccaggggctt gcccaaggcc     1020

aagagccatg ccccggaggt cataacgtcc tctccattaa ag                        1062


<210>  11
<211>  100
<212>  PRT
<213>  Homo sapiens

<400>  11

Lys Tyr Lys Asp Gly Asp Gln Cys Glu Thr Ser Pro Cys Gln Asn Gln 
1               5                   10                  15      


Gly Lys Cys Lys Asp Gly Leu Gly Glu Tyr Thr Cys Thr Cys Leu Glu 
            20                  25                  30          


Gly Phe Glu Gly Lys Asn Cys Glu Leu Phe Thr Arg Lys Leu Cys Ser 
        35                  40                  45              


Leu Asp Asn Gly Asp Cys Asp Gln Phe Cys His Glu Glu Gln Asn Ser 
    50                  55                  60                  


Val Val Cys Ser Cys Ala Arg Gly Tyr Thr Leu Ala Asp Asn Gly Lys 
65                  70                  75                  80  


Ala Cys Ile Pro Thr Gly Pro Tyr Pro Cys Gly Lys Gln Thr Leu Glu 
                85                  90                  95      


Arg Arg Lys Arg 
            100 


<210>  12
<211>  357
<212>  PRT
<213>  Homo sapiens

<400>  12

Lys Tyr Lys Asp Gly Asp Gln Cys Glu Thr Ser Pro Cys Gln Asn Gln 
1               5                   10                  15      


Gly Lys Cys Lys Asp Gly Leu Gly Glu Tyr Thr Cys Thr Cys Leu Glu 
            20                  25                  30          


Gly Phe Glu Gly Lys Asn Cys Glu Leu Phe Thr Arg Lys Leu Cys Ser 
        35                  40                  45              


Leu Asp Asn Gly Asp Cys Asp Gln Phe Cys His Glu Glu Gln Asn Ser 
    50                  55                  60                  


Val Val Cys Ser Cys Ala Arg Gly Tyr Thr Leu Ala Asp Asn Gly Lys 
65                  70                  75                  80  


Ala Cys Ile Pro Thr Gly Pro Tyr Pro Cys Gly Lys Gln Thr Leu Glu 
                85                  90                  95      


Arg Arg Lys Arg Arg Lys Arg Ile Val Gly Gly Gln Glu Cys Lys Asp 
            100                 105                 110         


Gly Glu Cys Pro Trp Gln Ala Leu Leu Ile Asn Glu Glu Asn Glu Gly 
        115                 120                 125             


Phe Cys Gly Gly Thr Ile Leu Ser Glu Phe Tyr Ile Leu Thr Ala Ala 
    130                 135                 140                 


His Cys Leu Tyr Gln Ala Lys Arg Phe Lys Val Arg Val Gly Asp Arg 
145                 150                 155                 160 


Asn Thr Glu Gln Glu Glu Gly Gly Glu Ala Val His Glu Val Glu Val 
                165                 170                 175     


Val Ile Lys His Asn Arg Phe Thr Tyr Glu Thr Tyr Asp Phe Asp Ile 
            180                 185                 190         


Ala Val Leu Arg Leu Lys Thr Pro Ile Thr Phe Arg Met Asn Val Ala 
        195                 200                 205             


Pro Ala Cys Leu Pro Glu Arg Asp Trp Ala Glu Ser Thr Leu Met Thr 
    210                 215                 220                 


Gln Lys Thr Gly Ile Val Ser Gly Phe Gly Arg Thr His Glu Lys Gly 
225                 230                 235                 240 


Arg Gln Ser Thr Arg Leu Lys Met Leu Glu Val Pro Tyr Val Asp Arg 
                245                 250                 255     


Asn Ser Cys Lys Leu Ser Ser Ser Phe Ile Ile Thr Gln Asn Met Phe 
            260                 265                 270         


Cys Ala Gly Tyr Asp Thr Lys Gln Glu Asp Ala Cys Gln Gly Asp Ser 
        275                 280                 285             


Gly Gly Pro His Val Thr Arg Phe Lys Asp Thr Tyr Phe Val Thr Gly 
    290                 295                 300                 


Ile Val Ser Trp Gly Glu Gly Cys Ala Arg Lys Gly Lys Tyr Gly Ile 
305                 310                 315                 320 


Tyr Thr Lys Val Thr Ala Phe Leu Lys Trp Ile Asp Arg Ser Met Lys 
                325                 330                 335     


Thr Arg Gly Leu Pro Lys Ala Lys Ser His Ala Pro Glu Val Ile Thr 
            340                 345                 350         


Ser Ser Pro Leu Lys 
        355         


<210>  13
<211>  357
<212>  PRT
<213>  Homo sapiens

<400>  13

Lys Tyr Lys Asp Gly Asp Gln Cys Glu Thr Ser Pro Cys Gln Asn Gln 
1               5                   10                  15      


Gly Lys Cys Lys Asp Gly Leu Gly Glu Tyr Thr Cys Thr Cys Leu Glu 
            20                  25                  30          


Gly Phe Glu Gly Lys Asn Cys Glu Leu Phe Thr Arg Lys Leu Cys Ser 
        35                  40                  45              


Leu Asp Asn Gly Asp Cys Asp Gln Phe Cys His Glu Glu Gln Asn Ser 
    50                  55                  60                  


Val Val Cys Ser Cys Ala Arg Gly Tyr Thr Leu Ala Asp Asn Gly Lys 
65                  70                  75                  80  


Ala Cys Ile Pro Thr Gly Pro Tyr Pro Cys Gly Lys Gln Thr Leu Glu 
                85                  90                  95      


Arg Arg Lys Arg Arg Lys Arg Ile Val Gly Gly Gln Glu Cys Lys Asp 
            100                 105                 110         


Gly Glu Cys Pro Trp Gln Ala Leu Leu Ile Asn Glu Glu Asn Glu Gly 
        115                 120                 125             


Phe Cys Gly Gly Thr Ile Leu Ser Glu Phe Tyr Ile Leu Thr Ala Ala 
    130                 135                 140                 


His Cys Leu Tyr Gln Ala Lys Arg Phe Lys Val Arg Val Gly Asp Arg 
145                 150                 155                 160 


Asn Thr Glu Gln Glu Glu Gly Gly Glu Ala Val His Glu Val Glu Val 
                165                 170                 175     


Val Ile Lys His Asn Arg Phe Thr Lys Glu Thr Tyr Asp Phe Asp Ile 
            180                 185                 190         


Ala Val Leu Arg Leu Lys Thr Pro Ile Thr Phe Arg Met Asn Val Ala 
        195                 200                 205             


Pro Ala Cys Leu Pro Glu Arg Asp Trp Ala Glu Ser Thr Leu Met Thr 
    210                 215                 220                 


Gln Lys Thr Gly Ile Val Ser Gly Phe Gly Arg Thr His Glu Lys Gly 
225                 230                 235                 240 


Gly Gln Ser Thr Arg Leu Lys Met Leu Glu Val Pro Tyr Val Asp Arg 
                245                 250                 255     


Asn Ser Cys Lys Leu Ser Ser Ser Phe Ile Ile Thr Gln Asn Met Phe 
            260                 265                 270         


Cys Ala Gly Tyr Asp Thr Lys Gln Glu Asp Ala Cys Gln Gly Asp Ser 
        275                 280                 285             


Gly Gly Pro His Val Thr Arg Phe Lys Asp Thr Tyr Phe Val Thr Gly 
    290                 295                 300                 


Ile Val Ser Trp Gly Glu Gly Cys Ala Arg Lys Gly Lys Tyr Gly Ile 
305                 310                 315                 320 


Tyr Thr Lys Val Thr Ala Phe Leu Lys Trp Ile Asp Arg Ser Met Lys 
                325                 330                 335     


Thr Arg Gly Leu Pro Lys Ala Lys Ser His Ala Pro Glu Val Ile Thr 
            340                 345                 350         


Ser Ser Pro Leu Lys 
        355         


<210>  14
<211>  357
<212>  PRT
<213>  Homo sapiens

<400>  14

Lys Tyr Lys Asp Gly Asp Gln Cys Glu Thr Ser Pro Cys Gln Asn Gln 
1               5                   10                  15      


Gly Lys Cys Lys Asp Gly Leu Gly Glu Tyr Thr Cys Thr Cys Leu Glu 
            20                  25                  30          


Gly Phe Glu Gly Lys Asn Cys Glu Leu Phe Thr Arg Lys Leu Cys Ser 
        35                  40                  45              


Leu Asp Asn Gly Asp Cys Asp Gln Phe Cys His Glu Glu Gln Asn Ser 
    50                  55                  60                  


Val Val Cys Ser Cys Ala Arg Gly Tyr Thr Leu Ala Asp Asn Gly Lys 
65                  70                  75                  80  


Ala Cys Ile Pro Thr Gly Pro Tyr Pro Cys Gly Lys Gln Thr Leu Glu 
                85                  90                  95      


Arg Arg Lys Arg Arg Lys Arg Ile Val Gly Gly Gln Glu Cys Lys Asp 
            100                 105                 110         


Gly Glu Cys Pro Trp Gln Ala Leu Leu Ile Asn Glu Glu Asn Glu Gly 
        115                 120                 125             


Phe Cys Gly Gly Thr Ile Leu Ser Glu Phe Tyr Ile Leu Thr Ala Ala 
    130                 135                 140                 


His Cys Leu Tyr Gln Ala Lys Arg Phe Lys Val Arg Val Gly Asp Arg 
145                 150                 155                 160 


Asn Thr Glu Gln Glu Glu Gly Gly Glu Ala Val His Glu Val Glu Val 
                165                 170                 175     


Val Ile Lys His Asn Arg Phe Thr Lys Glu Thr Tyr Asp Phe Asp Ile 
            180                 185                 190         


Ala Val Leu Arg Leu Lys Thr Pro Ile Thr Phe Arg Met Asn Val Ala 
        195                 200                 205             


Pro Ala Cys Leu Pro Glu Arg Asp Trp Ala Glu Ser Thr Leu Met Thr 
    210                 215                 220                 


Gln Lys Thr Gly Ile Val Ser Gly Phe Gly Arg Thr His Glu Lys Gly 
225                 230                 235                 240 


Ile Gln Ser Thr Arg Leu Lys Met Leu Glu Val Pro Tyr Val Asp Arg 
                245                 250                 255     


Asn Ser Cys Lys Leu Ser Ser Ser Phe Ile Ile Thr Gln Asn Met Phe 
            260                 265                 270         


Cys Ala Gly Tyr Asp Thr Lys Gln Glu Asp Ala Cys Gln Gly Asp Ser 
        275                 280                 285             


Gly Gly Pro His Val Thr Arg Phe Lys Asp Thr Tyr Phe Val Thr Gly 
    290                 295                 300                 


Ile Val Ser Trp Gly Glu Gly Cys Ala Arg Lys Gly Lys Tyr Gly Ile 
305                 310                 315                 320 


Tyr Thr Lys Val Thr Ala Phe Leu Lys Trp Ile Asp Arg Ser Met Lys 
                325                 330                 335     


Thr Arg Gly Leu Pro Lys Ala Lys Ser His Ala Pro Glu Val Ile Thr 
            340                 345                 350         


Ser Ser Pro Leu Lys 
        355         


<210>  15
<211>  357
<212>  PRT
<213>  Homo sapiens

<400>  15

Lys Tyr Lys Asp Gly Asp Gln Cys Glu Thr Ser Pro Cys Gln Asn Gln 
1               5                   10                  15      


Gly Lys Cys Lys Asp Gly Leu Gly Glu Tyr Thr Cys Thr Cys Leu Glu 
            20                  25                  30          


Gly Phe Glu Gly Lys Asn Cys Glu Leu Phe Thr Arg Lys Leu Cys Ser 
        35                  40                  45              


Leu Asp Asn Gly Asp Cys Asp Gln Phe Cys His Glu Glu Gln Asn Ser 
    50                  55                  60                  


Val Val Cys Ser Cys Ala Arg Gly Tyr Thr Leu Ala Asp Asn Gly Lys 
65                  70                  75                  80  


Ala Cys Ile Pro Thr Gly Pro Tyr Pro Cys Gly Lys Gln Thr Leu Glu 
                85                  90                  95      


Arg Arg Lys Arg Arg Lys Arg Ile Val Gly Gly Gln Glu Cys Lys Asp 
            100                 105                 110         


Gly Glu Cys Pro Trp Gln Ala Leu Leu Ile Asn Glu Glu Asn Glu Gly 
        115                 120                 125             


Phe Cys Gly Gly Thr Ile Leu Ser Glu Phe Tyr Ile Leu Thr Ala Ala 
    130                 135                 140                 


His Cys Leu Tyr Gln Ala Lys Arg Phe Lys Val Arg Val Gly Asp Arg 
145                 150                 155                 160 


Asn Thr Glu Gln Glu Glu Gly Gly Glu Ala Val His Glu Val Glu Val 
                165                 170                 175     


Val Ile Lys His Asn Arg Phe Thr Lys Glu Thr Tyr Asp Phe Asp Ile 
            180                 185                 190         


Ala Val Leu Arg Leu Lys Thr Pro Ile Thr Phe Arg Met Asn Val Ala 
        195                 200                 205             


Pro Ala Cys Leu Pro Glu Arg Asp Trp Ala Glu Ser Thr Leu Met Thr 
    210                 215                 220                 


Gln Lys Thr Gly Ile Val Ser Gly Phe Gly Arg Thr His Glu Lys Gly 
225                 230                 235                 240 


Tyr Gln Ser Thr Arg Leu Lys Met Leu Glu Val Pro Tyr Val Asp Arg 
                245                 250                 255     


Asn Ser Cys Lys Leu Ser Ser Ser Phe Ile Ile Thr Gln Asn Met Phe 
            260                 265                 270         


Cys Ala Gly Tyr Asp Thr Lys Gln Glu Asp Ala Cys Gln Gly Asp Ser 
        275                 280                 285             


Gly Gly Pro His Val Thr Arg Phe Lys Asp Thr Tyr Phe Val Thr Gly 
    290                 295                 300                 


Ile Val Ser Trp Gly Glu Gly Cys Ala Arg Lys Gly Lys Tyr Gly Ile 
305                 310                 315                 320 


Tyr Thr Lys Val Thr Ala Phe Leu Lys Trp Ile Asp Arg Ser Met Lys 
                325                 330                 335     


Thr Arg Gly Leu Pro Lys Ala Lys Ser His Ala Pro Glu Val Ile Thr 
            340                 345                 350         


Ser Ser Pro Leu Lys 
        355         


<210>  16
<211>  357
<212>  PRT
<213>  Homo sapiens

<400>  16

Lys Tyr Lys Asp Gly Asp Gln Cys Glu Thr Ser Pro Cys Gln Asn Gln 
1               5                   10                  15      


Gly Lys Cys Lys Asp Gly Leu Gly Glu Tyr Thr Cys Thr Cys Leu Glu 
            20                  25                  30          


Gly Phe Glu Gly Lys Asn Cys Glu Leu Phe Thr Arg Lys Leu Cys Ser 
        35                  40                  45              


Leu Asp Asn Gly Asp Cys Asp Gln Phe Cys His Glu Glu Gln Asn Ser 
    50                  55                  60                  


Val Val Cys Ser Cys Ala Arg Gly Tyr Thr Leu Ala Asp Asn Gly Lys 
65                  70                  75                  80  


Ala Cys Ile Pro Thr Gly Pro Tyr Pro Cys Gly Lys Gln Thr Leu Glu 
                85                  90                  95      


Arg Arg Lys Arg Arg Lys Arg Ile Val Gly Gly Gln Glu Cys Lys Asp 
            100                 105                 110         


Gly Glu Cys Pro Trp Gln Ala Leu Leu Ile Asn Glu Glu Asn Glu Gly 
        115                 120                 125             


Phe Cys Gly Gly Thr Ile Leu Ser Glu Phe Tyr Ile Leu Thr Ala Ala 
    130                 135                 140                 


His Cys Leu Tyr Gln Ala Lys Arg Phe Lys Val Arg Val Gly Asp Arg 
145                 150                 155                 160 


Asn Thr Glu Gln Glu Glu Gly Gly Glu Ala Val His Glu Val Glu Val 
                165                 170                 175     


Val Ile Lys His Asn Arg Phe Thr Lys Glu Thr Tyr Asp Phe Asp Ile 
            180                 185                 190         


Ala Val Leu Arg Leu Lys Thr Pro Ile Thr Phe Arg Met Asn Val Ala 
        195                 200                 205             


Pro Ala Cys Leu Pro Glu Arg Asp Trp Ala Glu Ser Thr Leu Met Thr 
    210                 215                 220                 


Gln Lys Thr Gly Ile Val Ser Gly Phe Gly Arg Thr His Glu Lys Gly 
225                 230                 235                 240 


Phe Gln Ser Thr Arg Leu Lys Met Leu Glu Val Pro Tyr Val Asp Arg 
                245                 250                 255     


Asn Ser Cys Lys Leu Ser Ser Ser Phe Ile Ile Thr Gln Asn Met Phe 
            260                 265                 270         


Cys Ala Gly Tyr Asp Thr Lys Gln Glu Asp Ala Cys Gln Gly Asp Ser 
        275                 280                 285             


Gly Gly Pro His Val Thr Arg Phe Lys Asp Thr Tyr Phe Val Thr Gly 
    290                 295                 300                 


Ile Val Ser Trp Gly Glu Gly Cys Ala Arg Lys Gly Lys Tyr Gly Ile 
305                 310                 315                 320 


Tyr Thr Lys Val Thr Ala Phe Leu Lys Trp Ile Asp Arg Ser Met Lys 
                325                 330                 335     


Thr Arg Gly Leu Pro Lys Ala Lys Ser His Ala Pro Glu Val Ile Thr 
            340                 345                 350         


Ser Ser Pro Leu Lys 
        355         


<210>  17
<211>  39
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  primer

<400>  17
ctggaacgca ggaagaggag gaagaggatc gtgggaggc                              39


<210>  18
<211>  39
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  primer

<400>  18
gcctcccacg atcctcttcc tcctcttcct gcgttccag                              39


<210>  19
<211>  18
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  MB7

<400>  19

Met Arg Trp Ser Trp Ile Phe Leu Leu Leu Leu Ser Ile Thr Ser Ala 
1               5                   10                  15      


Asn Ala 
        


<210>  20
<211>  13
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Etiquette HPC4 de GPAD1 et GPAD2

<400>  20

Cys Glu Asp Gln Val Asp Pro Arg Leu Ile Asp Gly Lys 
1               5                   10              


<210>  21
<211>  356
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  GPAD1

<400>  21

Ser Asn Lys Tyr Lys Asp Gly Asp Gln Cys Glu Thr Ser Pro Cys Gln 
1               5                   10                  15      


Asn Gln Gly Lys Cys Lys Asp Gly Leu Gly Glu Tyr Thr Cys Thr Cys 
            20                  25                  30          


Leu Glu Gly Phe Glu Gly Lys Asn Cys Glu Leu Phe Thr Arg Lys Leu 
        35                  40                  45              


Cys Ser Leu Asp Asn Gly Asp Cys Asp Gln Phe Cys His Glu Glu Gln 
    50                  55                  60                  


Asn Ser Val Val Cys Ser Cys Ala Arg Gly Tyr Thr Leu Ala Asp Asn 
65                  70                  75                  80  


Gly Lys Ala Cys Ile Pro Thr Gly Pro Tyr Pro Cys Gly Lys Gln Thr 
                85                  90                  95      


Leu Glu Arg Arg Lys Arg Ile Val Gly Gly Gln Glu Cys Lys Asp Gly 
            100                 105                 110         


Glu Cys Pro Trp Gln Ala Leu Leu Ile Asn Glu Glu Asn Glu Gly Phe 
        115                 120                 125             


Cys Gly Gly Thr Ile Leu Ser Glu Phe Tyr Ile Leu Thr Ala Ala His 
    130                 135                 140                 


Cys Leu Tyr Gln Ala Lys Arg Phe Lys Val Arg Val Gly Asp Arg Asn 
145                 150                 155                 160 


Thr Glu Gln Glu Glu Gly Gly Glu Ala Val His Glu Val Glu Val Val 
                165                 170                 175     


Ile Lys His Asn Arg Phe Thr Lys Glu Thr Tyr Asp Phe Asp Ile Ala 
            180                 185                 190         


Val Leu Arg Leu Lys Thr Pro Ile Thr Phe Arg Met Asn Val Ala Pro 
        195                 200                 205             


Ala Cys Leu Pro Glu Arg Asp Trp Ala Glu Ser Thr Leu Met Thr Gln 
    210                 215                 220                 


Lys Thr Gly Ile Val Ser Gly Phe Gly Arg Thr His Glu Lys Gly Arg 
225                 230                 235                 240 


Gln Ser Thr Arg Leu Lys Met Leu Glu Val Pro Tyr Val Asp Arg Asn 
                245                 250                 255     


Ser Cys Lys Leu Ser Ser Ser Phe Ile Ile Thr Gln Asn Met Phe Cys 
            260                 265                 270         


Ala Gly Tyr Asp Thr Lys Gln Glu Asp Ala Cys Gln Gly Asp Ser Gly 
        275                 280                 285             


Gly Pro His Val Thr Arg Phe Lys Asp Thr Tyr Phe Val Thr Gly Ile 
    290                 295                 300                 


Val Ser Trp Gly Glu Gly Cys Ala Arg Lys Gly Lys Tyr Gly Ile Tyr 
305                 310                 315                 320 


Thr Lys Val Thr Ala Phe Leu Lys Trp Ile Asp Arg Ser Met Lys Thr 
                325                 330                 335     


Arg Gly Leu Pro Lys Ala Lys Ser His Ala Pro Glu Val Ile Thr Ser 
            340                 345                 350         


Ser Pro Leu Lys 
        355     


<210>  22
<211>  359
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  GPAD2

<400>  22

Ser Asn Lys Tyr Lys Asp Gly Asp Gln Cys Glu Thr Ser Pro Cys Gln 
1               5                   10                  15      


Asn Gln Gly Lys Cys Lys Asp Gly Leu Gly Glu Tyr Thr Cys Thr Cys 
            20                  25                  30          


Leu Glu Gly Phe Glu Gly Lys Asn Cys Glu Leu Phe Thr Arg Lys Leu 
        35                  40                  45              


Cys Ser Leu Asp Asn Gly Asp Cys Asp Gln Phe Cys His Glu Glu Gln 
    50                  55                  60                  


Asn Ser Val Val Cys Ser Cys Ala Arg Gly Tyr Thr Leu Ala Asp Asn 
65                  70                  75                  80  


Gly Lys Ala Cys Ile Pro Thr Gly Pro Tyr Pro Cys Gly Lys Gln Thr 
                85                  90                  95      


Leu Glu Arg Arg Lys Arg Arg Lys Arg Ile Val Gly Gly Gln Glu Cys 
            100                 105                 110         


Lys Asp Gly Glu Cys Pro Trp Gln Ala Leu Leu Ile Asn Glu Glu Asn 
        115                 120                 125             


Glu Gly Phe Cys Gly Gly Thr Ile Leu Ser Glu Phe Tyr Ile Leu Thr 
    130                 135                 140                 


Ala Ala His Cys Leu Tyr Gln Ala Lys Arg Phe Lys Val Arg Val Gly 
145                 150                 155                 160 


Asp Arg Asn Thr Glu Gln Glu Glu Gly Gly Glu Ala Val His Glu Val 
                165                 170                 175     


Glu Val Val Ile Lys His Asn Arg Phe Thr Lys Glu Thr Tyr Asp Phe 
            180                 185                 190         


Asp Ile Ala Val Leu Arg Leu Lys Thr Pro Ile Thr Phe Arg Met Asn 
        195                 200                 205             


Val Ala Pro Ala Cys Leu Pro Glu Arg Asp Trp Ala Glu Ser Thr Leu 
    210                 215                 220                 


Met Thr Gln Lys Thr Gly Ile Val Ser Gly Phe Gly Arg Thr His Glu 
225                 230                 235                 240 


Lys Gly Arg Gln Ser Thr Arg Leu Lys Met Leu Glu Val Pro Tyr Val 
                245                 250                 255     


Asp Arg Asn Ser Cys Lys Leu Ser Ser Ser Phe Ile Ile Thr Gln Asn 
            260                 265                 270         


Met Phe Cys Ala Gly Tyr Asp Thr Lys Gln Glu Asp Ala Cys Gln Gly 
        275                 280                 285             


Asp Ser Gly Gly Pro His Val Thr Arg Phe Lys Asp Thr Tyr Phe Val 
    290                 295                 300                 


Thr Gly Ile Val Ser Trp Gly Glu Gly Cys Ala Arg Lys Gly Lys Tyr 
305                 310                 315                 320 


Gly Ile Tyr Thr Lys Val Thr Ala Phe Leu Lys Trp Ile Asp Arg Ser 
                325                 330                 335     


Met Lys Thr Arg Gly Leu Pro Lys Ala Lys Ser His Ala Pro Glu Val 
            340                 345                 350         


Ile Thr Ser Ser Pro Leu Lys 
        355                 


<210>  23
<211>  355
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  GPAD1 optimis

<400>  23

Asn Lys Tyr Lys Asp Gly Asp Gln Cys Glu Thr Ser Pro Cys Gln Asn 
1               5                   10                  15      


Gln Gly Lys Cys Lys Asp Gly Leu Gly Glu Tyr Thr Cys Thr Cys Leu 
            20                  25                  30          


Glu Gly Phe Glu Gly Lys Asn Cys Glu Leu Phe Thr Arg Lys Leu Cys 
        35                  40                  45              


Ser Leu Asp Asn Gly Asp Cys Asp Gln Phe Cys His Glu Glu Gln Asn 
    50                  55                  60                  


Ser Val Val Cys Ser Cys Ala Arg Gly Tyr Thr Leu Ala Asp Asn Gly 
65                  70                  75                  80  


Lys Ala Cys Ile Pro Thr Gly Pro Tyr Pro Cys Gly Lys Gln Thr Leu 
                85                  90                  95      


Glu Arg Arg Lys Arg Ile Val Gly Gly Gln Glu Cys Lys Asp Gly Glu 
            100                 105                 110         


Cys Pro Trp Gln Ala Leu Leu Ile Asn Glu Glu Asn Glu Gly Phe Cys 
        115                 120                 125             


Gly Gly Thr Ile Leu Ser Glu Phe Tyr Ile Leu Thr Ala Ala His Cys 
    130                 135                 140                 


Leu Tyr Gln Ala Lys Arg Phe Lys Val Arg Val Gly Asp Arg Asn Thr 
145                 150                 155                 160 


Glu Gln Glu Glu Gly Gly Glu Ala Val His Glu Val Glu Val Val Ile 
                165                 170                 175     


Lys His Asn Arg Phe Thr Lys Glu Thr Tyr Asp Phe Asp Ile Ala Val 
            180                 185                 190         


Leu Arg Leu Lys Thr Pro Ile Thr Phe Arg Met Asn Val Ala Pro Ala 
        195                 200                 205             


Cys Leu Pro Glu Arg Asp Trp Ala Glu Ser Thr Leu Met Thr Gln Lys 
    210                 215                 220                 


Thr Gly Ile Val Ser Gly Phe Gly Arg Thr His Glu Lys Gly Arg Gln 
225                 230                 235                 240 


Ser Thr Arg Leu Lys Met Leu Glu Val Pro Tyr Val Asp Arg Asn Ser 
                245                 250                 255     


Cys Lys Leu Ser Ser Ser Phe Ile Ile Thr Gln Asn Met Phe Cys Ala 
            260                 265                 270         


Gly Tyr Asp Thr Lys Gln Glu Asp Ala Cys Gln Gly Asp Ser Gly Gly 
        275                 280                 285             


Pro His Val Thr Arg Phe Lys Asp Thr Tyr Phe Val Thr Gly Ile Val 
    290                 295                 300                 


Ser Trp Gly Glu Gly Cys Ala Arg Lys Gly Lys Tyr Gly Ile Tyr Thr 
305                 310                 315                 320 


Lys Val Thr Ala Phe Leu Lys Trp Ile Asp Arg Ser Met Lys Thr Arg 
                325                 330                 335     


Gly Leu Pro Lys Ala Lys Ser His Ala Pro Glu Val Ile Thr Ser Ser 
            340                 345                 350         


Pro Leu Lys 
        355 


<210>  24
<211>  358
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  GPAD2 optimis

<400>  24

Asn Lys Tyr Lys Asp Gly Asp Gln Cys Glu Thr Ser Pro Cys Gln Asn 
1               5                   10                  15      


Gln Gly Lys Cys Lys Asp Gly Leu Gly Glu Tyr Thr Cys Thr Cys Leu 
            20                  25                  30          


Glu Gly Phe Glu Gly Lys Asn Cys Glu Leu Phe Thr Arg Lys Leu Cys 
        35                  40                  45              


Ser Leu Asp Asn Gly Asp Cys Asp Gln Phe Cys His Glu Glu Gln Asn 
    50                  55                  60                  


Ser Val Val Cys Ser Cys Ala Arg Gly Tyr Thr Leu Ala Asp Asn Gly 
65                  70                  75                  80  


Lys Ala Cys Ile Pro Thr Gly Pro Tyr Pro Cys Gly Lys Gln Thr Leu 
                85                  90                  95      


Glu Arg Arg Lys Arg Arg Lys Arg Ile Val Gly Gly Gln Glu Cys Lys 
            100                 105                 110         


Asp Gly Glu Cys Pro Trp Gln Ala Leu Leu Ile Asn Glu Glu Asn Glu 
        115                 120                 125             


Gly Phe Cys Gly Gly Thr Ile Leu Ser Glu Phe Tyr Ile Leu Thr Ala 
    130                 135                 140                 


Ala His Cys Leu Tyr Gln Ala Lys Arg Phe Lys Val Arg Val Gly Asp 
145                 150                 155                 160 


Arg Asn Thr Glu Gln Glu Glu Gly Gly Glu Ala Val His Glu Val Glu 
                165                 170                 175     


Val Val Ile Lys His Asn Arg Phe Thr Lys Glu Thr Tyr Asp Phe Asp 
            180                 185                 190         


Ile Ala Val Leu Arg Leu Lys Thr Pro Ile Thr Phe Arg Met Asn Val 
        195                 200                 205             


Ala Pro Ala Cys Leu Pro Glu Arg Asp Trp Ala Glu Ser Thr Leu Met 
    210                 215                 220                 


Thr Gln Lys Thr Gly Ile Val Ser Gly Phe Gly Arg Thr His Glu Lys 
225                 230                 235                 240 


Gly Arg Gln Ser Thr Arg Leu Lys Met Leu Glu Val Pro Tyr Val Asp 
                245                 250                 255     


Arg Asn Ser Cys Lys Leu Ser Ser Ser Phe Ile Ile Thr Gln Asn Met 
            260                 265                 270         


Phe Cys Ala Gly Tyr Asp Thr Lys Gln Glu Asp Ala Cys Gln Gly Asp 
        275                 280                 285             


Ser Gly Gly Pro His Val Thr Arg Phe Lys Asp Thr Tyr Phe Val Thr 
    290                 295                 300                 


Gly Ile Val Ser Trp Gly Glu Gly Cys Ala Arg Lys Gly Lys Tyr Gly 
305                 310                 315                 320 


Ile Tyr Thr Lys Val Thr Ala Phe Leu Lys Trp Ile Asp Arg Ser Met 
                325                 330                 335     


Lys Thr Arg Gly Leu Pro Lys Ala Lys Ser His Ala Pro Glu Val Ile 
            340                 345                 350         


Thr Ser Ser Pro Leu Lys 
        355             


<210>  25
<211>  102
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  SEQ ID NO:11 avec Ser-Asn- en N terminal

<400>  25

Ser Asn Lys Tyr Lys Asp Gly Asp Gln Cys Glu Thr Ser Pro Cys Gln 
1               5                   10                  15      


Asn Gln Gly Lys Cys Lys Asp Gly Leu Gly Glu Tyr Thr Cys Thr Cys 
            20                  25                  30          


Leu Glu Gly Phe Glu Gly Lys Asn Cys Glu Leu Phe Thr Arg Lys Leu 
        35                  40                  45              


Cys Ser Leu Asp Asn Gly Asp Cys Asp Gln Phe Cys His Glu Glu Gln 
    50                  55                  60                  


Asn Ser Val Val Cys Ser Cys Ala Arg Gly Tyr Thr Leu Ala Asp Asn 
65                  70                  75                  80  


Gly Lys Ala Cys Ile Pro Thr Gly Pro Tyr Pro Cys Gly Lys Gln Thr 
                85                  90                  95      


Leu Glu Arg Arg Lys Arg 
            100         


<210>  26
<211>  101
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  SEQ ID NO:11 avec Asn- en N terminal

<400>  26

Asn Lys Tyr Lys Asp Gly Asp Gln Cys Glu Thr Ser Pro Cys Gln Asn 
1               5                   10                  15      


Gln Gly Lys Cys Lys Asp Gly Leu Gly Glu Tyr Thr Cys Thr Cys Leu 
            20                  25                  30          


Glu Gly Phe Glu Gly Lys Asn Cys Glu Leu Phe Thr Arg Lys Leu Cys 
        35                  40                  45              


Ser Leu Asp Asn Gly Asp Cys Asp Gln Phe Cys His Glu Glu Gln Asn 
    50                  55                  60                  


Ser Val Val Cys Ser Cys Ala Arg Gly Tyr Thr Leu Ala Asp Asn Gly 
65                  70                  75                  80  


Lys Ala Cys Ile Pro Thr Gly Pro Tyr Pro Cys Gly Lys Gln Thr Leu 
                85                  90                  95      


Glu Arg Arg Lys Arg 
            100     


<210>  27
<211>  359
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Exemple de GPAD3

<400>  27

Asn Lys Tyr Lys Asp Gly Asp Gln Cys Glu Thr Ser Pro Cys Gln Asn 
1               5                   10                  15      


Gln Gly Lys Cys Lys Asp Gly Leu Gly Glu Tyr Thr Cys Thr Cys Leu 
            20                  25                  30          


Glu Gly Phe Glu Gly Lys Asn Cys Glu Leu Phe Thr Arg Lys Leu Cys 
        35                  40                  45              


Ser Leu Asp Asn Gly Asp Cys Asp Gln Phe Cys His Glu Glu Gln Asn 
    50                  55                  60                  


Ser Val Val Cys Ser Cys Ala Arg Gly Tyr Thr Leu Ala Asp Asn Gly 
65                  70                  75                  80  


Lys Ala Cys Ile Pro Thr Gly Pro Tyr Pro Cys Gly Lys Gln Thr Leu 
                85                  90                  95      


Glu Gly Ser Ser Gly Arg Arg Lys Arg Ile Val Gly Gly Gln Glu Cys 
            100                 105                 110         


Lys Asp Gly Glu Cys Pro Trp Gln Ala Leu Leu Ile Asn Glu Glu Asn 
        115                 120                 125             


Glu Gly Phe Cys Gly Gly Thr Ile Leu Ser Glu Phe Tyr Ile Leu Thr 
    130                 135                 140                 


Ala Ala His Cys Leu Tyr Gln Ala Lys Arg Phe Lys Val Arg Val Gly 
145                 150                 155                 160 


Asp Arg Asn Thr Glu Gln Glu Glu Gly Gly Glu Ala Val His Glu Val 
                165                 170                 175     


Glu Val Val Ile Lys His Asn Arg Phe Thr Lys Glu Thr Tyr Asp Phe 
            180                 185                 190         


Asp Ile Ala Val Leu Arg Leu Lys Thr Pro Ile Thr Phe Arg Met Asn 
        195                 200                 205             


Val Ala Pro Ala Cys Leu Pro Glu Arg Asp Trp Ala Glu Ser Thr Leu 
    210                 215                 220                 


Met Thr Gln Lys Thr Gly Ile Val Ser Gly Phe Gly Arg Thr His Glu 
225                 230                 235                 240 


Lys Gly Arg Gln Ser Thr Arg Leu Lys Met Leu Glu Val Pro Tyr Val 
                245                 250                 255     


Asp Arg Asn Ser Cys Lys Leu Ser Ser Ser Phe Ile Ile Thr Gln Asn 
            260                 265                 270         


Met Phe Cys Ala Gly Tyr Asp Thr Lys Gln Glu Asp Ala Cys Gln Gly 
        275                 280                 285             


Asp Ser Gly Gly Pro His Val Thr Arg Phe Lys Asp Thr Tyr Phe Val 
    290                 295                 300                 


Thr Gly Ile Val Ser Trp Gly Glu Gly Cys Ala Arg Lys Gly Lys Tyr 
305                 310                 315                 320 


Gly Ile Tyr Thr Lys Val Thr Ala Phe Leu Lys Trp Ile Asp Arg Ser 
                325                 330                 335     


Met Lys Thr Arg Gly Leu Pro Lys Ala Lys Ser His Ala Pro Glu Val 
            340                 345                 350         


Ile Thr Ser Ser Pro Leu Lys 
        355                 


<210>  28
<211>  360
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  GPAD3-LC

<400>  28

Asn Lys Tyr Lys Asp Gly Asp Gln Cys Glu Thr Ser Pro Cys Gln Asn 
1               5                   10                  15      


Gln Gly Lys Cys Lys Asp Gly Leu Gly Glu Tyr Thr Cys Thr Cys Leu 
            20                  25                  30          


Glu Gly Phe Glu Gly Lys Asn Cys Glu Leu Phe Thr Arg Lys Leu Cys 
        35                  40                  45              


Ser Leu Asp Asn Gly Asp Cys Asp Gln Phe Cys His Glu Glu Gln Asn 
    50                  55                  60                  


Ser Val Val Cys Ser Cys Ala Arg Gly Tyr Thr Leu Ala Asp Asn Gly 
65                  70                  75                  80  


Lys Ala Cys Ile Pro Thr Gly Pro Tyr Pro Cys Gly Lys Gln Thr Leu 
                85                  90                  95      


Glu Arg Gly Ser Ser Gly Arg Arg Lys Arg Ile Val Gly Gly Gln Glu 
            100                 105                 110         


Cys Lys Asp Gly Glu Cys Pro Trp Gln Ala Leu Leu Ile Asn Glu Glu 
        115                 120                 125             


Asn Glu Gly Phe Cys Gly Gly Thr Ile Leu Ser Glu Phe Tyr Ile Leu 
    130                 135                 140                 


Thr Ala Ala His Cys Leu Tyr Gln Ala Lys Arg Phe Lys Val Arg Val 
145                 150                 155                 160 


Gly Asp Arg Asn Thr Glu Gln Glu Glu Gly Gly Glu Ala Val His Glu 
                165                 170                 175     


Val Glu Val Val Ile Lys His Asn Arg Phe Thr Lys Glu Thr Tyr Asp 
            180                 185                 190         


Phe Asp Ile Ala Val Leu Arg Leu Lys Thr Pro Ile Thr Phe Arg Met 
        195                 200                 205             


Asn Val Ala Pro Ala Cys Leu Pro Glu Arg Asp Trp Ala Glu Ser Thr 
    210                 215                 220                 


Leu Met Thr Gln Lys Thr Gly Ile Val Ser Gly Phe Gly Arg Thr His 
225                 230                 235                 240 


Glu Lys Gly Arg Gln Ser Thr Arg Leu Lys Met Leu Glu Val Pro Tyr 
                245                 250                 255     


Val Asp Arg Asn Ser Cys Lys Leu Ser Ser Ser Phe Ile Ile Thr Gln 
            260                 265                 270         


Asn Met Phe Cys Ala Gly Tyr Asp Thr Lys Gln Glu Asp Ala Cys Gln 
        275                 280                 285             


Gly Asp Ser Gly Gly Pro His Val Thr Arg Phe Lys Asp Thr Tyr Phe 
    290                 295                 300                 


Val Thr Gly Ile Val Ser Trp Gly Glu Gly Cys Ala Arg Lys Gly Lys 
305                 310                 315                 320 


Tyr Gly Ile Tyr Thr Lys Val Thr Ala Phe Leu Lys Trp Ile Asp Arg 
                325                 330                 335     


Ser Met Lys Thr Arg Gly Leu Pro Lys Ala Lys Ser His Ala Pro Glu 
            340                 345                 350         


Val Ile Thr Ser Ser Pro Leu Lys 
        355                 360 


<210>  29
<211>  366
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  GPAD3-LL

<400>  29

Asn Lys Tyr Lys Asp Gly Asp Gln Cys Glu Thr Ser Pro Cys Gln Asn 
1               5                   10                  15      


Gln Gly Lys Cys Lys Asp Gly Leu Gly Glu Tyr Thr Cys Thr Cys Leu 
            20                  25                  30          


Glu Gly Phe Glu Gly Lys Asn Cys Glu Leu Phe Thr Arg Lys Leu Cys 
        35                  40                  45              


Ser Leu Asp Asn Gly Asp Cys Asp Gln Phe Cys His Glu Glu Gln Asn 
    50                  55                  60                  


Ser Val Val Cys Ser Cys Ala Arg Gly Tyr Thr Leu Ala Asp Asn Gly 
65                  70                  75                  80  


Lys Ala Cys Ile Pro Thr Gly Pro Tyr Pro Cys Gly Lys Gln Thr Leu 
                85                  90                  95      


Glu Arg Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Arg Arg Lys Arg 
            100                 105                 110         


Ile Val Gly Gly Gln Glu Cys Lys Asp Gly Glu Cys Pro Trp Gln Ala 
        115                 120                 125             


Leu Leu Ile Asn Glu Glu Asn Glu Gly Phe Cys Gly Gly Thr Ile Leu 
    130                 135                 140                 


Ser Glu Phe Tyr Ile Leu Thr Ala Ala His Cys Leu Tyr Gln Ala Lys 
145                 150                 155                 160 


Arg Phe Lys Val Arg Val Gly Asp Arg Asn Thr Glu Gln Glu Glu Gly 
                165                 170                 175     


Gly Glu Ala Val His Glu Val Glu Val Val Ile Lys His Asn Arg Phe 
            180                 185                 190         


Thr Lys Glu Thr Tyr Asp Phe Asp Ile Ala Val Leu Arg Leu Lys Thr 
        195                 200                 205             


Pro Ile Thr Phe Arg Met Asn Val Ala Pro Ala Cys Leu Pro Glu Arg 
    210                 215                 220                 


Asp Trp Ala Glu Ser Thr Leu Met Thr Gln Lys Thr Gly Ile Val Ser 
225                 230                 235                 240 


Gly Phe Gly Arg Thr His Glu Lys Gly Arg Gln Ser Thr Arg Leu Lys 
                245                 250                 255     


Met Leu Glu Val Pro Tyr Val Asp Arg Asn Ser Cys Lys Leu Ser Ser 
            260                 265                 270         


Ser Phe Ile Ile Thr Gln Asn Met Phe Cys Ala Gly Tyr Asp Thr Lys 
        275                 280                 285             


Gln Glu Asp Ala Cys Gln Gly Asp Ser Gly Gly Pro His Val Thr Arg 
    290                 295                 300                 


Phe Lys Asp Thr Tyr Phe Val Thr Gly Ile Val Ser Trp Gly Glu Gly 
305                 310                 315                 320 


Cys Ala Arg Lys Gly Lys Tyr Gly Ile Tyr Thr Lys Val Thr Ala Phe 
                325                 330                 335     


Leu Lys Trp Ile Asp Arg Ser Met Lys Thr Arg Gly Leu Pro Lys Ala 
            340                 345                 350         


Lys Ser His Ala Pro Glu Val Ile Thr Ser Ser Pro Leu Lys 
        355                 360                 365     


<210>  30
<211>  369
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  GPAD3-2F

<400>  30

Asn Lys Tyr Lys Asp Gly Asp Gln Cys Glu Thr Ser Pro Cys Gln Asn 
1               5                   10                  15      


Gln Gly Lys Cys Lys Asp Gly Leu Gly Glu Tyr Thr Cys Thr Cys Leu 
            20                  25                  30          


Glu Gly Phe Glu Gly Lys Asn Cys Glu Leu Phe Thr Arg Lys Leu Cys 
        35                  40                  45              


Ser Leu Asp Asn Gly Asp Cys Asp Gln Phe Cys His Glu Glu Gln Asn 
    50                  55                  60                  


Ser Val Val Cys Ser Cys Ala Arg Gly Tyr Thr Leu Ala Asp Asn Gly 
65                  70                  75                  80  


Lys Ala Cys Ile Pro Thr Gly Pro Tyr Pro Cys Gly Lys Gln Thr Leu 
                85                  90                  95      


Glu Arg Arg Lys Arg Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Arg 
            100                 105                 110         


Arg Lys Arg Ile Val Gly Gly Gln Glu Cys Lys Asp Gly Glu Cys Pro 
        115                 120                 125             


Trp Gln Ala Leu Leu Ile Asn Glu Glu Asn Glu Gly Phe Cys Gly Gly 
    130                 135                 140                 


Thr Ile Leu Ser Glu Phe Tyr Ile Leu Thr Ala Ala His Cys Leu Tyr 
145                 150                 155                 160 


Gln Ala Lys Arg Phe Lys Val Arg Val Gly Asp Arg Asn Thr Glu Gln 
                165                 170                 175     


Glu Glu Gly Gly Glu Ala Val His Glu Val Glu Val Val Ile Lys His 
            180                 185                 190         


Asn Arg Phe Thr Lys Glu Thr Tyr Asp Phe Asp Ile Ala Val Leu Arg 
        195                 200                 205             


Leu Lys Thr Pro Ile Thr Phe Arg Met Asn Val Ala Pro Ala Cys Leu 
    210                 215                 220                 


Pro Glu Arg Asp Trp Ala Glu Ser Thr Leu Met Thr Gln Lys Thr Gly 
225                 230                 235                 240 


Ile Val Ser Gly Phe Gly Arg Thr His Glu Lys Gly Arg Gln Ser Thr 
                245                 250                 255     


Arg Leu Lys Met Leu Glu Val Pro Tyr Val Asp Arg Asn Ser Cys Lys 
            260                 265                 270         


Leu Ser Ser Ser Phe Ile Ile Thr Gln Asn Met Phe Cys Ala Gly Tyr 
        275                 280                 285             


Asp Thr Lys Gln Glu Asp Ala Cys Gln Gly Asp Ser Gly Gly Pro His 
    290                 295                 300                 


Val Thr Arg Phe Lys Asp Thr Tyr Phe Val Thr Gly Ile Val Ser Trp 
305                 310                 315                 320 


Gly Glu Gly Cys Ala Arg Lys Gly Lys Tyr Gly Ile Tyr Thr Lys Val 
                325                 330                 335     


Thr Ala Phe Leu Lys Trp Ile Asp Arg Ser Met Lys Thr Arg Gly Leu 
            340                 345                 350         


Pro Lys Ala Lys Ser His Ala Pro Glu Val Ile Thr Ser Ser Pro Leu 
        355                 360                 365             


Lys 
    


<210>  31
<211>  266
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Chane lourde de FXa fusionn  SEQ ID NO:27

<400>  31

Ile Val Gly Gly Gln Glu Cys Lys Asp Gly Glu Cys Pro Trp Gln Ala 
1               5                   10                  15      


Leu Leu Ile Asn Glu Glu Asn Glu Gly Phe Cys Gly Gly Thr Ile Leu 
            20                  25                  30          


Ser Glu Phe Tyr Ile Leu Thr Ala Ala His Cys Leu Tyr Gln Ala Lys 
        35                  40                  45              


Arg Phe Lys Val Arg Val Gly Asp Arg Asn Thr Glu Gln Glu Glu Gly 
    50                  55                  60                  


Gly Glu Ala Val His Glu Val Glu Val Val Ile Lys His Asn Arg Phe 
65                  70                  75                  80  


Thr Lys Glu Thr Tyr Asp Phe Asp Ile Ala Val Leu Arg Leu Lys Thr 
                85                  90                  95      


Pro Ile Thr Phe Arg Met Asn Val Ala Pro Ala Cys Leu Pro Glu Arg 
            100                 105                 110         


Asp Trp Ala Glu Ser Thr Leu Met Thr Gln Lys Thr Gly Ile Val Ser 
        115                 120                 125             


Gly Phe Gly Arg Thr His Glu Lys Gly Arg Gln Ser Thr Arg Leu Lys 
    130                 135                 140                 


Met Leu Glu Val Pro Tyr Val Asp Arg Asn Ser Cys Lys Leu Ser Ser 
145                 150                 155                 160 


Ser Phe Ile Ile Thr Gln Asn Met Phe Cys Ala Gly Tyr Asp Thr Lys 
                165                 170                 175     


Gln Glu Asp Ala Cys Gln Gly Asp Ser Gly Gly Pro His Val Thr Arg 
            180                 185                 190         


Phe Lys Asp Thr Tyr Phe Val Thr Gly Ile Val Ser Trp Gly Glu Gly 
        195                 200                 205             


Cys Ala Arg Lys Gly Lys Tyr Gly Ile Tyr Thr Lys Val Thr Ala Phe 
    210                 215                 220                 


Leu Lys Trp Ile Asp Arg Ser Met Lys Thr Arg Gly Leu Pro Lys Ala 
225                 230                 235                 240 


Lys Ser His Ala Pro Glu Val Ile Thr Ser Ser Pro Leu Lys Glu Asp 
                245                 250                 255     


Gln Val Asp Pro Arg Leu Ile Asp Gly Lys 
            260                 265     


<210>  32
<211>  586
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  GPAD2-FX-Fc

<400>  32

Ser Asn Lys Tyr Lys Asp Gly Asp Gln Cys Glu Thr Ser Pro Cys Gln 
1               5                   10                  15      


Asn Gln Gly Lys Cys Lys Asp Gly Leu Gly Glu Tyr Thr Cys Thr Cys 
            20                  25                  30          


Leu Glu Gly Phe Glu Gly Lys Asn Cys Glu Leu Phe Thr Arg Lys Leu 
        35                  40                  45              


Cys Ser Leu Asp Asn Gly Asp Cys Asp Gln Phe Cys His Glu Glu Gln 
    50                  55                  60                  


Asn Ser Val Val Cys Ser Cys Ala Arg Gly Tyr Thr Leu Ala Asp Asn 
65                  70                  75                  80  


Gly Lys Ala Cys Ile Pro Thr Gly Pro Tyr Pro Cys Gly Lys Gln Thr 
                85                  90                  95      


Leu Glu Arg Arg Lys Arg Arg Lys Arg Ile Val Gly Gly Gln Glu Cys 
            100                 105                 110         


Lys Asp Gly Glu Cys Pro Trp Gln Ala Leu Leu Ile Asn Glu Glu Asn 
        115                 120                 125             


Glu Gly Phe Cys Gly Gly Thr Ile Leu Ser Glu Phe Tyr Ile Leu Thr 
    130                 135                 140                 


Ala Ala His Cys Leu Tyr Gln Ala Lys Arg Phe Lys Val Arg Val Gly 
145                 150                 155                 160 


Asp Arg Asn Thr Glu Gln Glu Glu Gly Gly Glu Ala Val His Glu Val 
                165                 170                 175     


Glu Val Val Ile Lys His Asn Arg Phe Thr Lys Glu Thr Tyr Asp Phe 
            180                 185                 190         


Asp Ile Ala Val Leu Arg Leu Lys Thr Pro Ile Thr Phe Arg Met Asn 
        195                 200                 205             


Val Ala Pro Ala Cys Leu Pro Glu Arg Asp Trp Ala Glu Ser Thr Leu 
    210                 215                 220                 


Met Thr Gln Lys Thr Gly Ile Val Ser Gly Phe Gly Arg Thr His Glu 
225                 230                 235                 240 


Lys Gly Arg Gln Ser Thr Arg Leu Lys Met Leu Glu Val Pro Tyr Val 
                245                 250                 255     


Asp Arg Asn Ser Cys Lys Leu Ser Ser Ser Phe Ile Ile Thr Gln Asn 
            260                 265                 270         


Met Phe Cys Ala Gly Tyr Asp Thr Lys Gln Glu Asp Ala Cys Gln Gly 
        275                 280                 285             


Asp Ser Gly Gly Pro His Val Thr Arg Phe Lys Asp Thr Tyr Phe Val 
    290                 295                 300                 


Thr Gly Ile Val Ser Trp Gly Glu Gly Cys Ala Arg Lys Gly Lys Tyr 
305                 310                 315                 320 


Gly Ile Tyr Thr Lys Val Thr Ala Phe Leu Lys Trp Ile Asp Arg Ser 
                325                 330                 335     


Met Lys Thr Arg Gly Leu Pro Lys Ala Lys Ser His Ala Pro Glu Val 
            340                 345                 350         


Ile Thr Ser Ser Pro Leu Lys Asp Lys Thr His Thr Cys Pro Pro Cys 
        355                 360                 365             


Pro Ala Pro Glu Leu Leu Gly Gly Pro Ser Val Phe Leu Phe Pro Pro 
    370                 375                 380                 


Lys Pro Lys Asp Thr Leu Met Ile Ser Arg Thr Pro Glu Val Thr Cys 
385                 390                 395                 400 


Val Val Val Asp Val Ser His Glu Asp Pro Glu Val Lys Phe Asn Trp 
                405                 410                 415     


Tyr Val Asp Gly Val Glu Val His Asn Ala Lys Thr Lys Pro Arg Glu 
            420                 425                 430         


Glu Gln Tyr Asn Ser Thr Tyr Arg Val Val Ser Val Leu Thr Val Leu 
        435                 440                 445             


His Gln Asp Trp Leu Asn Gly Lys Glu Tyr Lys Cys Lys Val Ser Asn 
    450                 455                 460                 


Lys Ala Leu Pro Ala Pro Ile Glu Lys Thr Ile Ser Lys Ala Lys Gly 
465                 470                 475                 480 


Gln Pro Arg Glu Pro Gln Val Tyr Thr Leu Pro Pro Ser Arg Asp Glu 
                485                 490                 495     


Leu Thr Lys Asn Gln Val Ser Leu Thr Cys Leu Val Lys Gly Phe Tyr 
            500                 505                 510         


Pro Ser Asp Ile Ala Val Glu Trp Glu Ser Asn Gly Gln Pro Glu Asn 
        515                 520                 525             


Asn Tyr Lys Thr Thr Pro Pro Val Leu Asp Ser Asp Gly Ser Phe Phe 
    530                 535                 540                 


Leu Tyr Ser Lys Leu Thr Val Asp Lys Ser Arg Trp Gln Gln Gly Asn 
545                 550                 555                 560 


Val Phe Ser Cys Ser Val Met His Glu Ala Leu His Asn His Tyr Thr 
                565                 570                 575     


Gln Lys Ser Leu Ser Leu Ser Pro Gly Lys 
            580                 585     


<210>  33
<211>  591
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  GPAD2-Fcl

<400>  33

Ser Asn Lys Tyr Lys Asp Gly Asp Gln Cys Glu Thr Ser Pro Cys Gln 
1               5                   10                  15      


Asn Gln Gly Lys Cys Lys Asp Gly Leu Gly Glu Tyr Thr Cys Thr Cys 
            20                  25                  30          


Leu Glu Gly Phe Glu Gly Lys Asn Cys Glu Leu Phe Thr Arg Lys Leu 
        35                  40                  45              


Cys Ser Leu Asp Asn Gly Asp Cys Asp Gln Phe Cys His Glu Glu Gln 
    50                  55                  60                  


Asn Ser Val Val Cys Ser Cys Ala Arg Gly Tyr Thr Leu Ala Asp Asn 
65                  70                  75                  80  


Gly Lys Ala Cys Ile Pro Thr Gly Pro Tyr Pro Cys Gly Lys Gln Thr 
                85                  90                  95      


Leu Glu Arg Arg Lys Arg Arg Lys Arg Ile Val Gly Gly Gln Glu Cys 
            100                 105                 110         


Lys Asp Gly Glu Cys Pro Trp Gln Ala Leu Leu Ile Asn Glu Glu Asn 
        115                 120                 125             


Glu Gly Phe Cys Gly Gly Thr Ile Leu Ser Glu Phe Tyr Ile Leu Thr 
    130                 135                 140                 


Ala Ala His Cys Leu Tyr Gln Ala Lys Arg Phe Lys Val Arg Val Gly 
145                 150                 155                 160 


Asp Arg Asn Thr Glu Gln Glu Glu Gly Gly Glu Ala Val His Glu Val 
                165                 170                 175     


Glu Val Val Ile Lys His Asn Arg Phe Thr Lys Glu Thr Tyr Asp Phe 
            180                 185                 190         


Asp Ile Ala Val Leu Arg Leu Lys Thr Pro Ile Thr Phe Arg Met Asn 
        195                 200                 205             


Val Ala Pro Ala Cys Leu Pro Glu Arg Asp Trp Ala Glu Ser Thr Leu 
    210                 215                 220                 


Met Thr Gln Lys Thr Gly Ile Val Ser Gly Phe Gly Arg Thr His Glu 
225                 230                 235                 240 


Lys Gly Arg Gln Ser Thr Arg Leu Lys Met Leu Glu Val Pro Tyr Val 
                245                 250                 255     


Asp Arg Asn Ser Cys Lys Leu Ser Ser Ser Phe Ile Ile Thr Gln Asn 
            260                 265                 270         


Met Phe Cys Ala Gly Tyr Asp Thr Lys Gln Glu Asp Ala Cys Gln Gly 
        275                 280                 285             


Asp Ser Gly Gly Pro His Val Thr Arg Phe Lys Asp Thr Tyr Phe Val 
    290                 295                 300                 


Thr Gly Ile Val Ser Trp Gly Glu Gly Cys Ala Arg Lys Gly Lys Tyr 
305                 310                 315                 320 


Gly Ile Tyr Thr Lys Val Thr Ala Phe Leu Lys Trp Ile Asp Arg Ser 
                325                 330                 335     


Met Lys Thr Arg Gly Leu Pro Lys Ala Lys Ser His Ala Pro Glu Val 
            340                 345                 350         


Ile Thr Ser Ser Pro Leu Lys Glu Pro Lys Ser Cys Asp Lys Thr His 
        355                 360                 365             


Thr Cys Pro Pro Cys Pro Ala Pro Glu Leu Leu Gly Gly Pro Ser Val 
    370                 375                 380                 


Phe Leu Phe Pro Pro Lys Pro Lys Asp Thr Leu Met Ile Ser Arg Thr 
385                 390                 395                 400 


Pro Glu Val Thr Cys Val Val Val Asp Val Ser His Glu Asp Pro Glu 
                405                 410                 415     


Val Lys Phe Asn Trp Tyr Val Asp Gly Val Glu Val His Asn Ala Lys 
            420                 425                 430         


Thr Lys Pro Arg Glu Glu Gln Tyr Asn Ser Thr Tyr Arg Val Val Ser 
        435                 440                 445             


Val Leu Thr Val Leu His Gln Asp Trp Leu Asn Gly Lys Glu Tyr Lys 
    450                 455                 460                 


Cys Lys Val Ser Asn Lys Ala Leu Pro Ala Pro Ile Glu Lys Thr Ile 
465                 470                 475                 480 


Ser Lys Ala Lys Gly Gln Pro Arg Glu Pro Gln Val Tyr Thr Leu Pro 
                485                 490                 495     


Pro Ser Arg Asp Glu Leu Thr Lys Asn Gln Val Ser Leu Thr Cys Leu 
            500                 505                 510         


Val Lys Gly Phe Tyr Pro Ser Asp Ile Ala Val Glu Trp Glu Ser Asn 
        515                 520                 525             


Gly Gln Pro Glu Asn Asn Tyr Lys Thr Thr Pro Pro Val Leu Asp Ser 
    530                 535                 540                 


Asp Gly Ser Phe Phe Leu Tyr Ser Lys Leu Thr Val Asp Lys Ser Arg 
545                 550                 555                 560 


Trp Gln Gln Gly Asn Val Phe Ser Cys Ser Val Met His Glu Ala Leu 
                565                 570                 575     


His Asn His Tyr Thr Gln Lys Ser Leu Ser Leu Ser Pro Gly Lys 
            580                 585                 590     


<210>  34
<211>  590
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  GPAD2-FcLss

<400>  34

Asn Lys Tyr Lys Asp Gly Asp Gln Cys Glu Thr Ser Pro Cys Gln Asn 
1               5                   10                  15      


Gln Gly Lys Cys Lys Asp Gly Leu Gly Glu Tyr Thr Cys Thr Cys Leu 
            20                  25                  30          


Glu Gly Phe Glu Gly Lys Asn Cys Glu Leu Phe Thr Arg Lys Leu Cys 
        35                  40                  45              


Ser Leu Asp Asn Gly Asp Cys Asp Gln Phe Cys His Glu Glu Gln Asn 
    50                  55                  60                  


Ser Val Val Cys Ser Cys Ala Arg Gly Tyr Thr Leu Ala Asp Asn Gly 
65                  70                  75                  80  


Lys Ala Cys Ile Pro Thr Gly Pro Tyr Pro Cys Gly Lys Gln Thr Leu 
                85                  90                  95      


Glu Arg Arg Lys Arg Arg Lys Arg Ile Val Gly Gly Gln Glu Cys Lys 
            100                 105                 110         


Asp Gly Glu Cys Pro Trp Gln Ala Leu Leu Ile Asn Glu Glu Asn Glu 
        115                 120                 125             


Gly Phe Cys Gly Gly Thr Ile Leu Ser Glu Phe Tyr Ile Leu Thr Ala 
    130                 135                 140                 


Ala His Cys Leu Tyr Gln Ala Lys Arg Phe Lys Val Arg Val Gly Asp 
145                 150                 155                 160 


Arg Asn Thr Glu Gln Glu Glu Gly Gly Glu Ala Val His Glu Val Glu 
                165                 170                 175     


Val Val Ile Lys His Asn Arg Phe Thr Lys Glu Thr Tyr Asp Phe Asp 
            180                 185                 190         


Ile Ala Val Leu Arg Leu Lys Thr Pro Ile Thr Phe Arg Met Asn Val 
        195                 200                 205             


Ala Pro Ala Cys Leu Pro Glu Arg Asp Trp Ala Glu Ser Thr Leu Met 
    210                 215                 220                 


Thr Gln Lys Thr Gly Ile Val Ser Gly Phe Gly Arg Thr His Glu Lys 
225                 230                 235                 240 


Gly Arg Gln Ser Thr Arg Leu Lys Met Leu Glu Val Pro Tyr Val Asp 
                245                 250                 255     


Arg Asn Ser Cys Lys Leu Ser Ser Ser Phe Ile Ile Thr Gln Asn Met 
            260                 265                 270         


Phe Cys Ala Gly Tyr Asp Thr Lys Gln Glu Asp Ala Cys Gln Gly Asp 
        275                 280                 285             


Ser Gly Gly Pro His Val Thr Arg Phe Lys Asp Thr Tyr Phe Val Thr 
    290                 295                 300                 


Gly Ile Val Ser Trp Gly Glu Gly Cys Ala Arg Lys Gly Lys Tyr Gly 
305                 310                 315                 320 


Ile Tyr Thr Lys Val Thr Ala Phe Leu Lys Trp Ile Asp Arg Ser Met 
                325                 330                 335     


Lys Thr Arg Gly Leu Pro Lys Ala Lys Ser His Ala Pro Glu Val Ile 
            340                 345                 350         


Thr Ser Ser Pro Leu Lys Glu Pro Lys Ser Cys Asp Lys Thr His Thr 
        355                 360                 365             


Cys Pro Pro Cys Pro Ala Pro Glu Leu Leu Gly Gly Pro Ser Val Phe 
    370                 375                 380                 


Leu Phe Pro Pro Lys Pro Lys Asp Thr Leu Met Ile Ser Arg Thr Pro 
385                 390                 395                 400 


Glu Val Thr Cys Val Val Val Asp Val Ser His Glu Asp Pro Glu Val 
                405                 410                 415     


Lys Phe Asn Trp Tyr Val Asp Gly Val Glu Val His Asn Ala Lys Thr 
            420                 425                 430         


Lys Pro Arg Glu Glu Gln Tyr Asn Ser Thr Tyr Arg Val Val Ser Val 
        435                 440                 445             


Leu Thr Val Leu His Gln Asp Trp Leu Asn Gly Lys Glu Tyr Lys Cys 
    450                 455                 460                 


Lys Val Ser Asn Lys Ala Leu Pro Ala Pro Ile Glu Lys Thr Ile Ser 
465                 470                 475                 480 


Lys Ala Lys Gly Gln Pro Arg Glu Pro Gln Val Tyr Thr Leu Pro Pro 
                485                 490                 495     


Ser Arg Asp Glu Leu Thr Lys Asn Gln Val Ser Leu Thr Cys Leu Val 
            500                 505                 510         


Lys Gly Phe Tyr Pro Ser Asp Ile Ala Val Glu Trp Glu Ser Asn Gly 
        515                 520                 525             


Gln Pro Glu Asn Asn Tyr Lys Thr Thr Pro Pro Val Leu Asp Ser Asp 
    530                 535                 540                 


Gly Ser Phe Phe Leu Tyr Ser Lys Leu Thr Val Asp Lys Ser Arg Trp 
545                 550                 555                 560 


Gln Gln Gly Asn Val Phe Ser Cys Ser Val Met His Glu Ala Leu His 
                565                 570                 575     


Asn His Tyr Thr Gln Lys Ser Leu Ser Leu Ser Pro Gly Lys 
            580                 585                 590 


<210>  35
<211>  831
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  GPAD2-scFcL

<400>  35

Ser Asn Lys Tyr Lys Asp Gly Asp Gln Cys Glu Thr Ser Pro Cys Gln 
1               5                   10                  15      


Asn Gln Gly Lys Cys Lys Asp Gly Leu Gly Glu Tyr Thr Cys Thr Cys 
            20                  25                  30          


Leu Glu Gly Phe Glu Gly Lys Asn Cys Glu Leu Phe Thr Arg Lys Leu 
        35                  40                  45              


Cys Ser Leu Asp Asn Gly Asp Cys Asp Gln Phe Cys His Glu Glu Gln 
    50                  55                  60                  


Asn Ser Val Val Cys Ser Cys Ala Arg Gly Tyr Thr Leu Ala Asp Asn 
65                  70                  75                  80  


Gly Lys Ala Cys Ile Pro Thr Gly Pro Tyr Pro Cys Gly Lys Gln Thr 
                85                  90                  95      


Leu Glu Arg Arg Lys Arg Arg Lys Arg Ile Val Gly Gly Gln Glu Cys 
            100                 105                 110         


Lys Asp Gly Glu Cys Pro Trp Gln Ala Leu Leu Ile Asn Glu Glu Asn 
        115                 120                 125             


Glu Gly Phe Cys Gly Gly Thr Ile Leu Ser Glu Phe Tyr Ile Leu Thr 
    130                 135                 140                 


Ala Ala His Cys Leu Tyr Gln Ala Lys Arg Phe Lys Val Arg Val Gly 
145                 150                 155                 160 


Asp Arg Asn Thr Glu Gln Glu Glu Gly Gly Glu Ala Val His Glu Val 
                165                 170                 175     


Glu Val Val Ile Lys His Asn Arg Phe Thr Lys Glu Thr Tyr Asp Phe 
            180                 185                 190         


Asp Ile Ala Val Leu Arg Leu Lys Thr Pro Ile Thr Phe Arg Met Asn 
        195                 200                 205             


Val Ala Pro Ala Cys Leu Pro Glu Arg Asp Trp Ala Glu Ser Thr Leu 
    210                 215                 220                 


Met Thr Gln Lys Thr Gly Ile Val Ser Gly Phe Gly Arg Thr His Glu 
225                 230                 235                 240 


Lys Gly Arg Gln Ser Thr Arg Leu Lys Met Leu Glu Val Pro Tyr Val 
                245                 250                 255     


Asp Arg Asn Ser Cys Lys Leu Ser Ser Ser Phe Ile Ile Thr Gln Asn 
            260                 265                 270         


Met Phe Cys Ala Gly Tyr Asp Thr Lys Gln Glu Asp Ala Cys Gln Gly 
        275                 280                 285             


Asp Ser Gly Gly Pro His Val Thr Arg Phe Lys Asp Thr Tyr Phe Val 
    290                 295                 300                 


Thr Gly Ile Val Ser Trp Gly Glu Gly Cys Ala Arg Lys Gly Lys Tyr 
305                 310                 315                 320 


Gly Ile Tyr Thr Lys Val Thr Ala Phe Leu Lys Trp Ile Asp Arg Ser 
                325                 330                 335     


Met Lys Thr Arg Gly Leu Pro Lys Ala Lys Ser His Ala Pro Glu Val 
            340                 345                 350         


Ile Thr Ser Ser Pro Leu Lys Asp Lys Thr His Thr Cys Pro Pro Cys 
        355                 360                 365             


Pro Ala Pro Glu Leu Leu Gly Gly Pro Ser Val Phe Leu Phe Pro Pro 
    370                 375                 380                 


Lys Pro Lys Asp Thr Leu Met Ile Ser Arg Thr Pro Glu Val Thr Cys 
385                 390                 395                 400 


Val Val Val Asp Val Ser His Glu Asp Pro Glu Val Lys Phe Asn Trp 
                405                 410                 415     


Tyr Val Asp Gly Val Glu Val His Asn Ala Lys Thr Lys Pro Arg Glu 
            420                 425                 430         


Glu Gln Tyr Asn Ser Thr Tyr Arg Val Val Ser Val Leu Thr Val Leu 
        435                 440                 445             


His Gln Asp Trp Leu Asn Gly Lys Glu Tyr Lys Cys Lys Val Ser Asn 
    450                 455                 460                 


Lys Ala Leu Pro Ala Pro Ile Glu Lys Thr Ile Ser Lys Ala Lys Gly 
465                 470                 475                 480 


Gln Pro Arg Glu Pro Gln Val Tyr Thr Leu Pro Pro Ser Arg Asp Glu 
                485                 490                 495     


Leu Thr Lys Asn Gln Val Ser Leu Thr Cys Leu Val Lys Gly Phe Tyr 
            500                 505                 510         


Pro Ser Asp Ile Ala Val Glu Trp Glu Ser Asn Gly Gln Pro Glu Asn 
        515                 520                 525             


Asn Tyr Lys Thr Thr Pro Pro Val Leu Asp Ser Asp Gly Ser Phe Phe 
    530                 535                 540                 


Leu Tyr Ser Lys Leu Thr Val Asp Lys Ser Arg Trp Gln Gln Gly Asn 
545                 550                 555                 560 


Val Phe Ser Cys Ser Val Met His Glu Ala Leu His Asn His Tyr Thr 
                565                 570                 575     


Gln Lys Ser Leu Ser Leu Ser Pro Gly Gly Gly Gly Gly Ser Gly Gly 
            580                 585                 590         


Gly Gly Ser Gly Gly Gly Gly Ser Glu Pro Lys Ser Ser Asp Lys Thr 
        595                 600                 605             


His Thr Cys Pro Pro Cys Pro Ala Pro Glu Leu Leu Gly Gly Pro Ser 
    610                 615                 620                 


Val Phe Leu Phe Pro Pro Lys Pro Lys Asp Thr Leu Met Ile Ser Arg 
625                 630                 635                 640 


Thr Pro Glu Val Thr Cys Val Val Val Asp Val Ser His Glu Asp Pro 
                645                 650                 655     


Glu Val Lys Phe Asn Trp Tyr Val Asp Gly Val Glu Val His Asn Ala 
            660                 665                 670         


Lys Thr Lys Pro Arg Glu Glu Gln Tyr Asn Ser Thr Tyr Arg Val Val 
        675                 680                 685             


Ser Val Leu Thr Val Leu His Gln Asp Trp Leu Asn Gly Lys Glu Tyr 
    690                 695                 700                 


Lys Cys Lys Val Ser Asn Lys Ala Leu Pro Ala Pro Ile Glu Lys Thr 
705                 710                 715                 720 


Ile Ser Lys Ala Lys Gly Gln Pro Arg Glu Pro Gln Val Tyr Thr Leu 
                725                 730                 735     


Pro Pro Ser Arg Asp Glu Leu Thr Lys Asn Gln Val Ser Leu Thr Cys 
            740                 745                 750         


Leu Val Lys Gly Phe Tyr Pro Ser Asp Ile Ala Val Glu Trp Glu Ser 
        755                 760                 765             


Asn Gly Gln Pro Glu Asn Asn Tyr Lys Thr Thr Pro Pro Val Leu Asp 
    770                 775                 780                 


Ser Asp Gly Ser Phe Phe Leu Tyr Ser Lys Leu Thr Val Asp Lys Ser 
785                 790                 795                 800 


Arg Trp Gln Gln Gly Asn Val Phe Ser Cys Ser Val Met His Glu Ala 
                805                 810                 815     


Leu His Asn His Tyr Thr Gln Lys Ser Leu Ser Leu Ser Pro Gly 
            820                 825                 830     


<210>  36
<211>  821
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  GPAD2-scFcS

<400>  36

Ser Asn Lys Tyr Lys Asp Gly Asp Gln Cys Glu Thr Ser Pro Cys Gln 
1               5                   10                  15      


Asn Gln Gly Lys Cys Lys Asp Gly Leu Gly Glu Tyr Thr Cys Thr Cys 
            20                  25                  30          


Leu Glu Gly Phe Glu Gly Lys Asn Cys Glu Leu Phe Thr Arg Lys Leu 
        35                  40                  45              


Cys Ser Leu Asp Asn Gly Asp Cys Asp Gln Phe Cys His Glu Glu Gln 
    50                  55                  60                  


Asn Ser Val Val Cys Ser Cys Ala Arg Gly Tyr Thr Leu Ala Asp Asn 
65                  70                  75                  80  


Gly Lys Ala Cys Ile Pro Thr Gly Pro Tyr Pro Cys Gly Lys Gln Thr 
                85                  90                  95      


Leu Glu Arg Arg Lys Arg Arg Lys Arg Ile Val Gly Gly Gln Glu Cys 
            100                 105                 110         


Lys Asp Gly Glu Cys Pro Trp Gln Ala Leu Leu Ile Asn Glu Glu Asn 
        115                 120                 125             


Glu Gly Phe Cys Gly Gly Thr Ile Leu Ser Glu Phe Tyr Ile Leu Thr 
    130                 135                 140                 


Ala Ala His Cys Leu Tyr Gln Ala Lys Arg Phe Lys Val Arg Val Gly 
145                 150                 155                 160 


Asp Arg Asn Thr Glu Gln Glu Glu Gly Gly Glu Ala Val His Glu Val 
                165                 170                 175     


Glu Val Val Ile Lys His Asn Arg Phe Thr Lys Glu Thr Tyr Asp Phe 
            180                 185                 190         


Asp Ile Ala Val Leu Arg Leu Lys Thr Pro Ile Thr Phe Arg Met Asn 
        195                 200                 205             


Val Ala Pro Ala Cys Leu Pro Glu Arg Asp Trp Ala Glu Ser Thr Leu 
    210                 215                 220                 


Met Thr Gln Lys Thr Gly Ile Val Ser Gly Phe Gly Arg Thr His Glu 
225                 230                 235                 240 


Lys Gly Arg Gln Ser Thr Arg Leu Lys Met Leu Glu Val Pro Tyr Val 
                245                 250                 255     


Asp Arg Asn Ser Cys Lys Leu Ser Ser Ser Phe Ile Ile Thr Gln Asn 
            260                 265                 270         


Met Phe Cys Ala Gly Tyr Asp Thr Lys Gln Glu Asp Ala Cys Gln Gly 
        275                 280                 285             


Asp Ser Gly Gly Pro His Val Thr Arg Phe Lys Asp Thr Tyr Phe Val 
    290                 295                 300                 


Thr Gly Ile Val Ser Trp Gly Glu Gly Cys Ala Arg Lys Gly Lys Tyr 
305                 310                 315                 320 


Gly Ile Tyr Thr Lys Val Thr Ala Phe Leu Lys Trp Ile Asp Arg Ser 
                325                 330                 335     


Met Lys Thr Arg Gly Leu Pro Lys Ala Lys Ser His Ala Pro Glu Val 
            340                 345                 350         


Ile Thr Ser Ser Pro Leu Lys Asp Lys Thr His Thr Cys Pro Pro Cys 
        355                 360                 365             


Pro Ala Pro Glu Leu Leu Gly Gly Pro Ser Val Phe Leu Phe Pro Pro 
    370                 375                 380                 


Lys Pro Lys Asp Thr Leu Met Ile Ser Arg Thr Pro Glu Val Thr Cys 
385                 390                 395                 400 


Val Val Val Asp Val Ser His Glu Asp Pro Glu Val Lys Phe Asn Trp 
                405                 410                 415     


Tyr Val Asp Gly Val Glu Val His Asn Ala Lys Thr Lys Pro Arg Glu 
            420                 425                 430         


Glu Gln Tyr Asn Ser Thr Tyr Arg Val Val Ser Val Leu Thr Val Leu 
        435                 440                 445             


His Gln Asp Trp Leu Asn Gly Lys Glu Tyr Lys Cys Lys Val Ser Asn 
    450                 455                 460                 


Lys Ala Leu Pro Ala Pro Ile Glu Lys Thr Ile Ser Lys Ala Lys Gly 
465                 470                 475                 480 


Gln Pro Arg Glu Pro Gln Val Tyr Thr Leu Pro Pro Ser Arg Asp Glu 
                485                 490                 495     


Leu Thr Lys Asn Gln Val Ser Leu Thr Cys Leu Val Lys Gly Phe Tyr 
            500                 505                 510         


Pro Ser Asp Ile Ala Val Glu Trp Glu Ser Asn Gly Gln Pro Glu Asn 
        515                 520                 525             


Asn Tyr Lys Thr Thr Pro Pro Val Leu Asp Ser Asp Gly Ser Phe Phe 
    530                 535                 540                 


Leu Tyr Ser Lys Leu Thr Val Asp Lys Ser Arg Trp Gln Gln Gly Asn 
545                 550                 555                 560 


Val Phe Ser Cys Ser Val Met His Glu Ala Leu His Asn His Tyr Thr 
                565                 570                 575     


Gln Lys Ser Leu Ser Leu Ser Pro Gly Gly Gly Gly Gly Ser Glu Pro 
            580                 585                 590         


Lys Ser Ser Asp Lys Thr His Thr Cys Pro Pro Cys Pro Ala Pro Glu 
        595                 600                 605             


Leu Leu Gly Gly Pro Ser Val Phe Leu Phe Pro Pro Lys Pro Lys Asp 
    610                 615                 620                 


Thr Leu Met Ile Ser Arg Thr Pro Glu Val Thr Cys Val Val Val Asp 
625                 630                 635                 640 


Val Ser His Glu Asp Pro Glu Val Lys Phe Asn Trp Tyr Val Asp Gly 
                645                 650                 655     


Val Glu Val His Asn Ala Lys Thr Lys Pro Arg Glu Glu Gln Tyr Asn 
            660                 665                 670         


Ser Thr Tyr Arg Val Val Ser Val Leu Thr Val Leu His Gln Asp Trp 
        675                 680                 685             


Leu Asn Gly Lys Glu Tyr Lys Cys Lys Val Ser Asn Lys Ala Leu Pro 
    690                 695                 700                 


Ala Pro Ile Glu Lys Thr Ile Ser Lys Ala Lys Gly Gln Pro Arg Glu 
705                 710                 715                 720 


Pro Gln Val Tyr Thr Leu Pro Pro Ser Arg Asp Glu Leu Thr Lys Asn 
                725                 730                 735     


Gln Val Ser Leu Thr Cys Leu Val Lys Gly Phe Tyr Pro Ser Asp Ile 
            740                 745                 750         


Ala Val Glu Trp Glu Ser Asn Gly Gln Pro Glu Asn Asn Tyr Lys Thr 
        755                 760                 765             


Thr Pro Pro Val Leu Asp Ser Asp Gly Ser Phe Phe Leu Tyr Ser Lys 
    770                 775                 780                 


Leu Thr Val Asp Lys Ser Arg Trp Gln Gln Gly Asn Val Phe Ser Cys 
785                 790                 795                 800 


Ser Val Met His Glu Ala Leu His Asn His Tyr Thr Gln Lys Ser Leu 
                805                 810                 815     


Ser Leu Ser Pro Gly 
            820     


<210>  37
<211>  835
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  scFcL-GPAD2

<400>  37

Asp Lys Thr His Thr Cys Pro Pro Cys Pro Ala Pro Glu Leu Leu Gly 
1               5                   10                  15      


Gly Pro Ser Val Phe Leu Phe Pro Pro Lys Pro Lys Asp Thr Leu Met 
            20                  25                  30          


Ile Ser Arg Thr Pro Glu Val Thr Cys Val Val Val Asp Val Ser His 
        35                  40                  45              


Glu Asp Pro Glu Val Lys Phe Asn Trp Tyr Val Asp Gly Val Glu Val 
    50                  55                  60                  


His Asn Ala Lys Thr Lys Pro Arg Glu Glu Gln Tyr Asn Ser Thr Tyr 
65                  70                  75                  80  


Arg Val Val Ser Val Leu Thr Val Leu His Gln Asp Trp Leu Asn Gly 
                85                  90                  95      


Lys Glu Tyr Lys Cys Lys Val Ser Asn Lys Ala Leu Pro Ala Pro Ile 
            100                 105                 110         


Glu Lys Thr Ile Ser Lys Ala Lys Gly Gln Pro Arg Glu Pro Gln Val 
        115                 120                 125             


Tyr Thr Leu Pro Pro Ser Arg Asp Glu Leu Thr Lys Asn Gln Val Ser 
    130                 135                 140                 


Leu Thr Cys Leu Val Lys Gly Phe Tyr Pro Ser Asp Ile Ala Val Glu 
145                 150                 155                 160 


Trp Glu Ser Asn Gly Gln Pro Glu Asn Asn Tyr Lys Thr Thr Pro Pro 
                165                 170                 175     


Val Leu Asp Ser Asp Gly Ser Phe Phe Leu Tyr Ser Lys Leu Thr Val 
            180                 185                 190         


Asp Lys Ser Arg Trp Gln Gln Gly Asn Val Phe Ser Cys Ser Val Met 
        195                 200                 205             


His Glu Ala Leu His Asn His Tyr Thr Gln Lys Ser Leu Ser Leu Ser 
    210                 215                 220                 


Pro Gly Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly 
225                 230                 235                 240 


Ser Glu Pro Lys Ser Ser Asp Lys Thr His Thr Cys Pro Pro Cys Pro 
                245                 250                 255     


Ala Pro Glu Leu Leu Gly Gly Pro Ser Val Phe Leu Phe Pro Pro Lys 
            260                 265                 270         


Pro Lys Asp Thr Leu Met Ile Ser Arg Thr Pro Glu Val Thr Cys Val 
        275                 280                 285             


Val Val Asp Val Ser His Glu Asp Pro Glu Val Lys Phe Asn Trp Tyr 
    290                 295                 300                 


Val Asp Gly Val Glu Val His Asn Ala Lys Thr Lys Pro Arg Glu Glu 
305                 310                 315                 320 


Gln Tyr Asn Ser Thr Tyr Arg Val Val Ser Val Leu Thr Val Leu His 
                325                 330                 335     


Gln Asp Trp Leu Asn Gly Lys Glu Tyr Lys Cys Lys Val Ser Asn Lys 
            340                 345                 350         


Ala Leu Pro Ala Pro Ile Glu Lys Thr Ile Ser Lys Ala Lys Gly Gln 
        355                 360                 365             


Pro Arg Glu Pro Gln Val Tyr Thr Leu Pro Pro Ser Arg Asp Glu Leu 
    370                 375                 380                 


Thr Lys Asn Gln Val Ser Leu Thr Cys Leu Val Lys Gly Phe Tyr Pro 
385                 390                 395                 400 


Ser Asp Ile Ala Val Glu Trp Glu Ser Asn Gly Gln Pro Glu Asn Asn 
                405                 410                 415     


Tyr Lys Thr Thr Pro Pro Val Leu Asp Ser Asp Gly Ser Phe Phe Leu 
            420                 425                 430         


Tyr Ser Lys Leu Thr Val Asp Lys Ser Arg Trp Gln Gln Gly Asn Val 
        435                 440                 445             


Phe Ser Cys Ser Val Met His Glu Ala Leu His Asn His Tyr Thr Gln 
    450                 455                 460                 


Lys Ser Leu Ser Leu Ser Pro Gly Gly Gly Gly Gly Ser Asn Lys Tyr 
465                 470                 475                 480 


Lys Asp Gly Asp Gln Cys Glu Thr Ser Pro Cys Gln Asn Gln Gly Lys 
                485                 490                 495     


Cys Lys Asp Gly Leu Gly Glu Tyr Thr Cys Thr Cys Leu Glu Gly Phe 
            500                 505                 510         


Glu Gly Lys Asn Cys Glu Leu Phe Thr Arg Lys Leu Cys Ser Leu Asp 
        515                 520                 525             


Asn Gly Asp Cys Asp Gln Phe Cys His Glu Glu Gln Asn Ser Val Val 
    530                 535                 540                 


Cys Ser Cys Ala Arg Gly Tyr Thr Leu Ala Asp Asn Gly Lys Ala Cys 
545                 550                 555                 560 


Ile Pro Thr Gly Pro Tyr Pro Cys Gly Lys Gln Thr Leu Glu Arg Arg 
                565                 570                 575     


Lys Arg Arg Lys Arg Ile Val Gly Gly Gln Glu Cys Lys Asp Gly Glu 
            580                 585                 590         


Cys Pro Trp Gln Ala Leu Leu Ile Asn Glu Glu Asn Glu Gly Phe Cys 
        595                 600                 605             


Gly Gly Thr Ile Leu Ser Glu Phe Tyr Ile Leu Thr Ala Ala His Cys 
    610                 615                 620                 


Leu Tyr Gln Ala Lys Arg Phe Lys Val Arg Val Gly Asp Arg Asn Thr 
625                 630                 635                 640 


Glu Gln Glu Glu Gly Gly Glu Ala Val His Glu Val Glu Val Val Ile 
                645                 650                 655     


Lys His Asn Arg Phe Thr Lys Glu Thr Tyr Asp Phe Asp Ile Ala Val 
            660                 665                 670         


Leu Arg Leu Lys Thr Pro Ile Thr Phe Arg Met Asn Val Ala Pro Ala 
        675                 680                 685             


Cys Leu Pro Glu Arg Asp Trp Ala Glu Ser Thr Leu Met Thr Gln Lys 
    690                 695                 700                 


Thr Gly Ile Val Ser Gly Phe Gly Arg Thr His Glu Lys Gly Arg Gln 
705                 710                 715                 720 


Ser Thr Arg Leu Lys Met Leu Glu Val Pro Tyr Val Asp Arg Asn Ser 
                725                 730                 735     


Cys Lys Leu Ser Ser Ser Phe Ile Ile Thr Gln Asn Met Phe Cys Ala 
            740                 745                 750         


Gly Tyr Asp Thr Lys Gln Glu Asp Ala Cys Gln Gly Asp Ser Gly Gly 
        755                 760                 765             


Pro His Val Thr Arg Phe Lys Asp Thr Tyr Phe Val Thr Gly Ile Val 
    770                 775                 780                 


Ser Trp Gly Glu Gly Cys Ala Arg Lys Gly Lys Tyr Gly Ile Tyr Thr 
785                 790                 795                 800 


Lys Val Thr Ala Phe Leu Lys Trp Ile Asp Arg Ser Met Lys Thr Arg 
                805                 810                 815     


Gly Leu Pro Lys Ala Lys Ser His Ala Pro Glu Val Ile Thr Ser Ser 
            820                 825                 830         


Pro Leu Lys 
        835 


<210>  38
<211>  832
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  scFcL-GPAD1

<400>  38

Asp Lys Thr His Thr Cys Pro Pro Cys Pro Ala Pro Glu Leu Leu Gly 
1               5                   10                  15      


Gly Pro Ser Val Phe Leu Phe Pro Pro Lys Pro Lys Asp Thr Leu Met 
            20                  25                  30          


Ile Ser Arg Thr Pro Glu Val Thr Cys Val Val Val Asp Val Ser His 
        35                  40                  45              


Glu Asp Pro Glu Val Lys Phe Asn Trp Tyr Val Asp Gly Val Glu Val 
    50                  55                  60                  


His Asn Ala Lys Thr Lys Pro Arg Glu Glu Gln Tyr Asn Ser Thr Tyr 
65                  70                  75                  80  


Arg Val Val Ser Val Leu Thr Val Leu His Gln Asp Trp Leu Asn Gly 
                85                  90                  95      


Lys Glu Tyr Lys Cys Lys Val Ser Asn Lys Ala Leu Pro Ala Pro Ile 
            100                 105                 110         


Glu Lys Thr Ile Ser Lys Ala Lys Gly Gln Pro Arg Glu Pro Gln Val 
        115                 120                 125             


Tyr Thr Leu Pro Pro Ser Arg Asp Glu Leu Thr Lys Asn Gln Val Ser 
    130                 135                 140                 


Leu Thr Cys Leu Val Lys Gly Phe Tyr Pro Ser Asp Ile Ala Val Glu 
145                 150                 155                 160 


Trp Glu Ser Asn Gly Gln Pro Glu Asn Asn Tyr Lys Thr Thr Pro Pro 
                165                 170                 175     


Val Leu Asp Ser Asp Gly Ser Phe Phe Leu Tyr Ser Lys Leu Thr Val 
            180                 185                 190         


Asp Lys Ser Arg Trp Gln Gln Gly Asn Val Phe Ser Cys Ser Val Met 
        195                 200                 205             


His Glu Ala Leu His Asn His Tyr Thr Gln Lys Ser Leu Ser Leu Ser 
    210                 215                 220                 


Pro Gly Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly 
225                 230                 235                 240 


Ser Glu Pro Lys Ser Ser Asp Lys Thr His Thr Cys Pro Pro Cys Pro 
                245                 250                 255     


Ala Pro Glu Leu Leu Gly Gly Pro Ser Val Phe Leu Phe Pro Pro Lys 
            260                 265                 270         


Pro Lys Asp Thr Leu Met Ile Ser Arg Thr Pro Glu Val Thr Cys Val 
        275                 280                 285             


Val Val Asp Val Ser His Glu Asp Pro Glu Val Lys Phe Asn Trp Tyr 
    290                 295                 300                 


Val Asp Gly Val Glu Val His Asn Ala Lys Thr Lys Pro Arg Glu Glu 
305                 310                 315                 320 


Gln Tyr Asn Ser Thr Tyr Arg Val Val Ser Val Leu Thr Val Leu His 
                325                 330                 335     


Gln Asp Trp Leu Asn Gly Lys Glu Tyr Lys Cys Lys Val Ser Asn Lys 
            340                 345                 350         


Ala Leu Pro Ala Pro Ile Glu Lys Thr Ile Ser Lys Ala Lys Gly Gln 
        355                 360                 365             


Pro Arg Glu Pro Gln Val Tyr Thr Leu Pro Pro Ser Arg Asp Glu Leu 
    370                 375                 380                 


Thr Lys Asn Gln Val Ser Leu Thr Cys Leu Val Lys Gly Phe Tyr Pro 
385                 390                 395                 400 


Ser Asp Ile Ala Val Glu Trp Glu Ser Asn Gly Gln Pro Glu Asn Asn 
                405                 410                 415     


Tyr Lys Thr Thr Pro Pro Val Leu Asp Ser Asp Gly Ser Phe Phe Leu 
            420                 425                 430         


Tyr Ser Lys Leu Thr Val Asp Lys Ser Arg Trp Gln Gln Gly Asn Val 
        435                 440                 445             


Phe Ser Cys Ser Val Met His Glu Ala Leu His Asn His Tyr Thr Gln 
    450                 455                 460                 


Lys Ser Leu Ser Leu Ser Pro Gly Gly Gly Gly Gly Ser Asn Lys Tyr 
465                 470                 475                 480 


Lys Asp Gly Asp Gln Cys Glu Thr Ser Pro Cys Gln Asn Gln Gly Lys 
                485                 490                 495     


Cys Lys Asp Gly Leu Gly Glu Tyr Thr Cys Thr Cys Leu Glu Gly Phe 
            500                 505                 510         


Glu Gly Lys Asn Cys Glu Leu Phe Thr Arg Lys Leu Cys Ser Leu Asp 
        515                 520                 525             


Asn Gly Asp Cys Asp Gln Phe Cys His Glu Glu Gln Asn Ser Val Val 
    530                 535                 540                 


Cys Ser Cys Ala Arg Gly Tyr Thr Leu Ala Asp Asn Gly Lys Ala Cys 
545                 550                 555                 560 


Ile Pro Thr Gly Pro Tyr Pro Cys Gly Lys Gln Thr Leu Glu Arg Arg 
                565                 570                 575     


Lys Arg Ile Val Gly Gly Gln Glu Cys Lys Asp Gly Glu Cys Pro Trp 
            580                 585                 590         


Gln Ala Leu Leu Ile Asn Glu Glu Asn Glu Gly Phe Cys Gly Gly Thr 
        595                 600                 605             


Ile Leu Ser Glu Phe Tyr Ile Leu Thr Ala Ala His Cys Leu Tyr Gln 
    610                 615                 620                 


Ala Lys Arg Phe Lys Val Arg Val Gly Asp Arg Asn Thr Glu Gln Glu 
625                 630                 635                 640 


Glu Gly Gly Glu Ala Val His Glu Val Glu Val Val Ile Lys His Asn 
                645                 650                 655     


Arg Phe Thr Lys Glu Thr Tyr Asp Phe Asp Ile Ala Val Leu Arg Leu 
            660                 665                 670         


Lys Thr Pro Ile Thr Phe Arg Met Asn Val Ala Pro Ala Cys Leu Pro 
        675                 680                 685             


Glu Arg Asp Trp Ala Glu Ser Thr Leu Met Thr Gln Lys Thr Gly Ile 
    690                 695                 700                 


Val Ser Gly Phe Gly Arg Thr His Glu Lys Gly Arg Gln Ser Thr Arg 
705                 710                 715                 720 


Leu Lys Met Leu Glu Val Pro Tyr Val Asp Arg Asn Ser Cys Lys Leu 
                725                 730                 735     


Ser Ser Ser Phe Ile Ile Thr Gln Asn Met Phe Cys Ala Gly Tyr Asp 
            740                 745                 750         


Thr Lys Gln Glu Asp Ala Cys Gln Gly Asp Ser Gly Gly Pro His Val 
        755                 760                 765             


Thr Arg Phe Lys Asp Thr Tyr Phe Val Thr Gly Ile Val Ser Trp Gly 
    770                 775                 780                 


Glu Gly Cys Ala Arg Lys Gly Lys Tyr Gly Ile Tyr Thr Lys Val Thr 
785                 790                 795                 800 


Ala Phe Leu Lys Trp Ile Asp Arg Ser Met Lys Thr Arg Gly Leu Pro 
                805                 810                 815     


Lys Ala Lys Ser His Ala Pro Glu Val Ile Thr Ser Ser Pro Leu Lys 
            820                 825                 830         


<210>  39
<211>  226
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Fragment Fc, ventuellement suivi d'une lysine

<400>  39

Asp Lys Thr His Thr Cys Pro Pro Cys Pro Ala Pro Glu Leu Leu Gly 
1               5                   10                  15      


Gly Pro Ser Val Phe Leu Phe Pro Pro Lys Pro Lys Asp Thr Leu Met 
            20                  25                  30          


Ile Ser Arg Thr Pro Glu Val Thr Cys Val Val Val Asp Val Ser His 
        35                  40                  45              


Glu Asp Pro Glu Val Lys Phe Asn Trp Tyr Val Asp Gly Val Glu Val 
    50                  55                  60                  


His Asn Ala Lys Thr Lys Pro Arg Glu Glu Gln Tyr Asn Ser Thr Tyr 
65                  70                  75                  80  


Arg Val Val Ser Val Leu Thr Val Leu His Gln Asp Trp Leu Asn Gly 
                85                  90                  95      


Lys Glu Tyr Lys Cys Lys Val Ser Asn Lys Ala Leu Pro Ala Pro Ile 
            100                 105                 110         


Glu Lys Thr Ile Ser Lys Ala Lys Gly Gln Pro Arg Glu Pro Gln Val 
        115                 120                 125             


Tyr Thr Leu Pro Pro Ser Arg Asp Glu Leu Thr Lys Asn Gln Val Ser 
    130                 135                 140                 


Leu Thr Cys Leu Val Lys Gly Phe Tyr Pro Ser Asp Ile Ala Val Glu 
145                 150                 155                 160 


Trp Glu Ser Asn Gly Gln Pro Glu Asn Asn Tyr Lys Thr Thr Pro Pro 
                165                 170                 175     


Val Leu Asp Ser Asp Gly Ser Phe Phe Leu Tyr Ser Lys Leu Thr Val 
            180                 185                 190         


Asp Lys Ser Arg Trp Gln Gln Gly Asn Val Phe Ser Cys Ser Val Met 
        195                 200                 205             


His Glu Ala Leu His Asn His Tyr Thr Gln Lys Ser Leu Ser Leu Ser 
    210                 215                 220                 


Pro Gly 
225     


<210>  40
<211>  1068
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Squence nuclique codant GPAD1 (SEQ ID NO:21)

<400>  40
agcaataaat acaaagatgg cgaccagtgt gagaccagtc cttgccagaa ccagggcaaa       60

tgtaaagacg gcctcgggga atacacctgc acctgtttag aaggattcga aggcaaaaac      120

tgtgaattat tcacacggaa gctctgcagc ctggacaacg gggactgtga ccagttctgc      180

cacgaggaac agaactctgt ggtgtgctcc tgcgcccgcg ggtacaccct ggctgacaac      240

ggcaaggcct gcattcccac agggccctac ccctgtggga aacagaccct ggaacgcagg      300

aagaggatcg tgggaggcca ggaatgcaag gacggggagt gtccctggca ggccctgctc      360

atcaatgagg aaaacgaggg tttctgtggt ggaaccattc tgagcgagtt ctacatccta      420

acggcagccc actgtctcta ccaagccaag agattcaagg tgagggtagg ggaccggaac      480

acggagcagg aggagggcgg tgaggcggtg cacgaggtgg aggtggtcat caagcacaac      540

cggttcacaa aggagaccta tgacttcgac atcgccgtgc tccggctcaa gacccccatc      600

accttccgca tgaacgtggc gcctgcctgc ctccccgagc gtgactgggc cgagtccacg      660

ctgatgacgc agaagacggg gattgtgagc ggcttcgggc gcacccacga gaagggccgg      720

cagtccacca ggctcaagat gctggaggtg ccctacgtgg accgcaacag ctgcaagctg      780

tccagcagct tcatcatcac ccagaacatg ttctgtgccg gctacgacac caagcaggag      840

gatgcctgcc agggggacag cgggggcccg cacgtcaccc gcttcaagga cacctacttc      900

gtgacaggca tcgtcagctg gggagagggc tgtgcccgta aggggaagta cgggatctac      960

accaaggtca ccgccttcct caagtggatc gacaggtcca tgaaaaccag gggcttgccc     1020

aaggccaaga gccatgcccc ggaggtcata acgtcctctc cattaaag                  1068


<210>  41
<211>  1077
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Squence nuclique codant GPAD2 (SEQ ID NO:22)

<400>  41
agcaataaat acaaagatgg cgaccagtgt gagaccagtc cttgccagaa ccagggcaaa       60

tgtaaagacg gcctcgggga atacacctgc acctgtttag aaggattcga aggcaaaaac      120

tgtgaattat tcacacggaa gctctgcagc ctggacaacg gggactgtga ccagttctgc      180

cacgaggaac agaactctgt ggtgtgctcc tgcgcccgcg ggtacaccct ggctgacaac      240

ggcaaggcct gcattcccac agggccctac ccctgtggga aacagaccct ggaacgcagg      300

aagaggagga agaggatcgt gggaggccag gaatgcaagg acggggagtg tccctggcag      360

gccctgctca tcaatgagga aaacgagggt ttctgtggtg gaaccattct gagcgagttc      420

tacatcctaa cggcagccca ctgtctctac caagccaaga gattcaaggt gagggtaggg      480

gaccggaaca cggagcagga ggagggcggt gaggcggtgc acgaggtgga ggtggtcatc      540

aagcacaacc ggttcacaaa ggagacctat gacttcgaca tcgccgtgct ccggctcaag      600

acccccatca ccttccgcat gaacgtggcg cctgcctgcc tccccgagcg tgactgggcc      660

gagtccacgc tgatgacgca gaagacgggg attgtgagcg gcttcgggcg cacccacgag      720

aagggccggc agtccaccag gctcaagatg ctggaggtgc cctacgtgga ccgcaacagc      780

tgcaagctgt ccagcagctt catcatcacc cagaacatgt tctgtgccgg ctacgacacc      840

aagcaggagg atgcctgcca gggggacagc gggggcccgc acgtcacccg cttcaaggac      900

acctacttcg tgacaggcat cgtcagctgg ggagagggct gtgcccgtaa ggggaagtac      960

gggatctaca ccaaggtcac cgccttcctc aagtggatcg acaggtccat gaaaaccagg     1020

ggcttgccca aggccaagag ccatgccccg gaggtcataa cgtcctctcc attaaag        1077


<210>  42
<211>  1065
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Squence nuclique codant GPAD1optimis (SEQ ID NO:23)

<400>  42
aacaagtata aagacggaga ccagtgtgag actagccctt gccagaacca ggggaagtgt       60

aaagatggac tgggcgagta cacctgcaca tgtctggagg gattcgaagg caagaattgc      120

gaactgttta ctagaaaact gtgtagcctg gataacggcg actgcgatca gttctgtcac      180

gaggaacaga attcagtggt ctgcagctgt gccaggggat acaccctggc cgacaacggc      240

aaggcttgca tccctaccgg cccctatcct tgtgggaaac agacactgga gcggagaaag      300

aggatcgtgg gcgggcagga gtgcaaggat ggagaatgtc catggcaggc cctgctgatt      360

aacgaggaaa atgagggctt ctgcggaggc actatcctgt ccgaatttta cattctgacc      420

gccgctcatt gtctgtatca ggccaagcgg ttcaaggtgc gggtcggcga cagaaacaca      480

gagcaggagg aagggggaga agctgtgcac gaggtcgaag tggtcatcaa gcataatcgc      540

ttcactaaag agacctacga ctttgatatc gcagtgctga gactgaagac accaattact      600

ttcaggatga atgtcgcacc agcatgcctg ccagagcgag attgggctga atccaccctg      660

atgacacaga aaactggcat tgtgtctggg tttggacgga cacacgagaa ggggaggcag      720

agcactcgcc tgaaaatgct ggaagtgccc tacgtcgaca ggaactcctg taagctgagc      780

tcctctttca tcattacaca gaatatgttt tgcgcagggt atgacactaa gcaggaggat      840

gcctgtcagg gagactctgg aggacctcac gtgacccgct tcaaagatac ttattttgtg      900

accggaatcg tcagttgggg agagggatgc gctcgaaagg ggaaatacgg aatctatacc      960

aaggtgacag cattcctgaa atggattgac cgaagtatga agacccgggg cctgcctaag     1020

gctaaatcac atgcaccaga agtgatcaca agttcacccc tgaag                     1065


<210>  43
<211>  1074
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Squence nuclique codant GPAD2 optimis (SEQ ID NO:24)

<400>  43
aacaagtata aagacggaga ccagtgtgag actagccctt gccagaacca ggggaagtgt       60

aaagatggac tgggcgagta cacctgcaca tgtctggagg gattcgaagg caagaattgc      120

gaactgttta ctagaaaact gtgtagcctg gataacggcg actgcgatca gttctgtcac      180

gaggaacaga attcagtggt ctgcagctgt gccaggggat acaccctggc cgacaacggc      240

aaggcttgca tccctaccgg cccctatcct tgtgggaaac agacactgga gcggagaaag      300

aggcgcaaac ggatcgtggg cgggcaggag tgcaaggatg gagaatgtcc atggcaggcc      360

ctgctgatta acgaggaaaa tgagggcttc tgcggaggca ctatcctgtc cgaattttac      420

attctgaccg ccgctcattg tctgtatcag gccaagcggt tcaaggtgcg ggtcggcgac      480

agaaacacag agcaggagga agggggagaa gctgtgcacg aggtcgaagt ggtcatcaag      540

cataatcgct tcactaaaga gacctacgac tttgatatcg cagtgctgag actgaagaca      600

ccaattactt tcaggatgaa tgtcgcacca gcatgcctgc cagagcgaga ttgggctgaa      660

tccaccctga tgacacagaa aactggcatt gtgtctgggt ttggacggac acacgagaag      720

gggaggcaga gcactcgcct gaaaatgctg gaagtgccct acgtcgacag gaactcctgt      780

aagctgagct cctctttcat cattacacag aatatgtttt gcgcagggta tgacactaag      840

caggaggatg cctgtcaggg agactctgga ggacctcacg tgacccgctt caaagatact      900

tattttgtga ccggaatcgt cagttgggga gagggatgcg ctcgaaaggg gaaatacgga      960

atctatacca aggtgacagc attcctgaaa tggattgacc gaagtatgaa gacccggggc     1020

ctgcctaagg ctaaatcaca tgcaccagaa gtgatcacaa gttcacccct gaag           1074


<210>  44
<211>  762
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Squence nuclique codant SEQ ID NO:31

<400>  44
atcgtgggcg ggcaggagtg caaggatgga gaatgtccat ggcaggccct gctgattaac       60

gaggaaaatg agggcttctg cggaggcact atcctgtccg aattttacat tctgaccgcc      120

gctcattgtc tgtatcaggc caagcggttc aaggtgcggg tcggcgacag aaacacagag      180

caggaggaag ggggagaagc tgtgcacgag gtcgaagtgg tcatcaagca taatcgcttc      240

actaaagaga cctacgactt tgatatcgca gtgctgagac tgaagacacc aattactttc      300

aggatgaatg tcgcaccagc atgcctgcca gagcgagatt gggctgaatc caccctgatg      360

acacagaaaa ctggcattgt gtctgggttt ggacggacac acgagaaggg gaggcagagc      420

actcgcctga aaatgctgga agtgccctac gtcgacagga actcctgtaa gctgagctcc      480

tctttcatca ttacacagaa tatgttttgc gcagggtatg acactaagca ggaggatgcc      540

tgtcagggag actctggagg acctcacgtg acccgcttca aagatactta ttttgtgacc      600

ggaatcgtca gttggggaga gggatgcgct cgaaagggga aatacggaat ctataccaag      660

gtgacagcat tcctgaaatg gattgaccga agtatgaaga cccggggcct gcctaaggct      720

aaatcacatg caccagaagt gatcacaagt tcacccctga ag                         762


<210>  45
<211>  1758
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Squence nuclique codant GPAD2-FX-Fc (SEQ ID NO:32)

<400>  45
agcaataaat acaaagatgg cgaccagtgt gagaccagtc cttgccagaa ccagggcaaa       60

tgtaaagacg gcctcgggga atacacctgc acctgtttag aaggattcga aggcaaaaac      120

tgtgaattat tcacacggaa gctctgcagc ctggacaacg gggactgtga ccagttctgc      180

cacgaggaac agaactctgt ggtgtgctcc tgcgcccgcg ggtacaccct ggctgacaac      240

ggcaaggcct gcattcccac agggccctac ccctgtggga aacagaccct ggaacgcagg      300

aagaggagga agaggatcgt gggaggccag gaatgcaagg acggggagtg tccctggcag      360

gccctgctca tcaatgagga aaacgagggt ttctgtggtg gaaccattct gagcgagttc      420

tacatcctaa cggcagccca ctgtctctac caagccaaga gattcaaggt gagggtaggg      480

gaccggaaca cggagcagga ggagggcggt gaggcggtgc acgaggtgga ggtggtcatc      540

aagcacaacc ggttcacaaa ggagacctat gacttcgaca tcgccgtgct ccggctcaag      600

acccccatca ccttccgcat gaacgtggcg cctgcctgcc tccccgagcg tgactgggcc      660

gagtccacgc tgatgacgca gaagacgggg attgtgagcg gcttcgggcg cacccacgag      720

aagggccggc agtccaccag gctcaagatg ctggaggtgc cctacgtgga ccgcaacagc      780

tgcaagctgt ccagcagctt catcatcacc cagaacatgt tctgtgccgg ctacgacacc      840

aagcaggagg atgcctgcca gggggacagc gggggcccgc acgtcacccg cttcaaggac      900

acctacttcg tgacaggcat cgtcagctgg ggagagggct gtgcccgtaa ggggaagtac      960

gggatctaca ccaaggtcac cgccttcctc aagtggatcg acaggtccat gaaaaccagg     1020

ggcttgccca aggccaagag ccatgccccg gaggtcataa cgtcctctcc attaaaggac     1080

aagacacaca catgccctcc ttgtccagcc cctgagctgc tgggcggccc ctccgtgttc     1140

ctgttccccc ccaagcctaa ggataccctg atgatcagca gaacccccga ggtgacctgc     1200

gtggtggtgg acgtgtccca cgaggatccc gaggtgaagt tcaactggta cgtggacggc     1260

gtggaggtgc acaacgctaa gaccaagccc agagaggagc agtacaacag cacatacaga     1320

gtggtgtctg tgctgaccgt gctgcaccag gactggctga acgggaagga gtacaagtgc     1380

aaggtgtcca acaaggccct gcctgcccct atcgagaaga ccatctctaa ggctaagggg     1440

cagccccggg agccacaggt gtacaccctg ccacccagcc gcgacgagct gaccaagaac     1500

caggtgtccc tgacatgcct ggtgaaggga ttctacccca gcgacatcgc cgtggagtgg     1560

gagagcaacg gccagcccga gaacaactac aagacaaccc ctcccgtgct ggacagcgat     1620

ggatccttct tcctgtactc caagctgacc gtggacaaga gcaggtggca gcagggaaac     1680

gtgttctctt gttccgtgat gcacgaggct ctgcacaacc actacaccca gaagtccctg     1740

agcctgtctc caggcaag                                                   1758


<210>  46
<211>  1773
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Squence nuclique codant GPAD2-Fcl (SEQ ID NO:33)

<400>  46
agcaataagt ataaagacgg ggatcagtgc gagacctccc catgtcagaa ccagggcaag       60

tgcaaagacg ggctgggaga gtacacatgc acttgtctgg aggggttcga aggaaagaat      120

tgcgaactgt ttacaagaaa gctgtgcagc ctggataacg gcgactgcga tcagttctgt      180

cacgaggaac agaatagtgt ggtctgctca tgtgccaggg ggtacactct ggctgacaac      240

ggaaaggcat gcatccctac tggaccttat ccatgtggca aacagaccct ggagcggaga      300

aagaggcgca aacgcatcgt gggcgggcag gagtgcaagg atggagaatg tccatggcag      360

gctctgctga ttaacgagga aaatgagggc ttctgcggag gcacaatcct gagcgagttc      420

tacattctga ctgccgctca ttgtctgtat caggctaagc ggttcaaggt gcgggtcggc      480

gacagaaaca ccgagcagga ggaaggggga gaagcagtgc acgaggtcga agtggtcatc      540

aagcataatc gcttcacaaa agagacttac gactttgata tcgccgtgct gagactgaag      600

acccccatta cattcaggat gaatgtggca ccagcatgcc tgcctgagcg agattgggct      660

gaatcaactc tgatgaccca gaaaacagga attgtgagcg gctttgggcg aactcacgag      720

aagggcaggc agagcacccg cctgaaaatg ctggaagtgc cctacgtcga ccggaacagc      780

tgtaagctga gctcctcttt catcattacc cagaatatgt tttgcgccgg ctatgacaca      840

aagcaggagg atgcttgtca gggggactcc ggaggacctc atgtgaccag attcaaagat      900

acatattttg tgactggcat cgtctcttgg ggagaaggct gcgccaggaa gggcaaatac      960

gggatctata ctaaggtgac cgccttcctg aaatggattg atcgatccat gaagactcgg     1020

ggcctgccaa aggcaaaatc tcacgccccc gaagtgatca ccagttcacc tctgaaggaa     1080

cctaagtctt gcgacaaaac ccatacatgc ccaccttgtc cagcacctga actgctggga     1140

ggaccatccg tgttcctgtt tccacccaag cccaaagata cactgatgat tagtcggacc     1200

cctgaggtga catgcgtggt cgtggatgtc tcacacgagg acccagaagt gaagtttaac     1260

tggtacgtgg acggcgtgga agtccataat gccaagacca aacctcgcga ggaacagtac     1320

aacagtacat atcgagtcgt gtcagtgctg actgtcctgc accaggattg gctgaacgga     1380

aaggagtata agtgcaaagt gagcaataag gctctgccag cacccatcga gaaaacaatt     1440

tccaaggcaa aaggccagcc aagggaaccc caggtgtaca ctctgcctcc aagccgcgat     1500

gagctgacaa agaaccaggt gtccctgact tgtctggtca aagggttcta tccctccgac     1560

atcgccgtgg agtgggaatc taatggacag cctgagaaca attacaagac cacaccccct     1620

gtgctggact cagatgggag cttctttctg tattctaagc tgactgtgga caaaagtaga     1680

tggcagcagg gaaacgtgtt ttcttgcagt gtcatgcacg aggccctgca caatcattac     1740

acccagaagt cactgagcct gtccccagga aag                                  1773


<210>  47
<211>  1770
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Squence nuclique codant GPAD2-FcLss (SEQ ID NO:34)

<400>  47
aataagtata aagacgggga tcagtgcgag acctctcctt gtcagaacca gggcaagtgc       60

aaagacgggc tgggagagta cacatgcact tgtctggagg ggttcgaagg aaagaattgc      120

gaactgttta caagaaaact gtgtagcctg gataacgggg actgcgatca gttctgtcac      180

gaggaacaga attccgtggt ctgctcttgt gcaagggggt acaccctggc tgacaacgga      240

aaggcatgca tccctactgg accttatcca tgtggcaaac agaccctgga gcggagaaag      300

aggcgcaaac gcatcgtggg cgggcaggag tgcaaggatg gagaatgtcc atggcaggct      360

ctgctgatta acgaggaaaa tgagggcttc tgcggaggca caatcctgag cgaattttac      420

attctgactg ccgctcattg tctgtatcag gctaagcggt tcaaggtgcg ggtcggcgac      480

agaaacaccg agcaggagga agggggagaa gcagtgcacg aggtcgaagt ggtcatcaag      540

cataatcgct tcacaaaaga gacttacgac tttgatatcg ccgtgctgag actgaagacc      600

cccattacat tcaggatgaa tgtggcacca gcatgcctgc ctgagcgaga ttgggctgaa      660

tctactctga tgacccagaa aacaggaatt gtgagtggct ttgggcgaac tcacgagaag      720

ggcaggcagt ctacccgcct gaaaatgctg gaagtgccct acgtcgaccg gaacagctgt      780

aagctgagct cctctttcat cattacccag aatatgtttt gcgccggcta tgacacaaag      840

caggaggatg cttgtcaggg ggacagcgga ggacctcatg tgaccagatt caaagataca      900

tattttgtga ctggcatcgt ctcctgggga gaaggctgcg caaggaaggg caaatacggg      960

atctatacta aggtgaccgc cttcctgaaa tggattgatc gatcaatgaa gactcggggc     1020

ctgccaaagg caaaaagcca cgcccccgaa gtgatcacca gttcacctct gaaggaacca     1080

aagagctgcg acaaaaccca tacatgccca ccttgtccag cacctgaact gctgggagga     1140

ccatccgtgt tcctgtttcc acccaagccc aaagatacac tgatgatttc ccggacccct     1200

gaggtgacat gtgtggtcgt ggatgtctct cacgaggacc cagaagtgaa gtttaactgg     1260

tacgtggacg gcgtggaagt ccataatgcc aagaccaaac cccgcgagga acagtacaac     1320

tccacatatc gagtcgtgtc tgtgctgact gtcctgcacc aggattggct gaacggaaaa     1380

gagtacaagt gcaaagtgag taataaggct ctgccagcac ccatcgagaa aacaatttcc     1440

aaggcaaaag gccagccaag ggaaccccag gtgtacactc tgcctccaag tcgcgatgag     1500

ctgacaaaga accaggtgtc actgacttgt ctggtcaaag ggttctatcc ctcagacatc     1560

gccgtggagt gggaaagcaa tggacagcct gagaacaatt acaagaccac accccctgtg     1620

ctggactctg atgggagttt ctttctgtat agcaagctga ctgtggacaa atccagatgg     1680

cagcagggaa acgtgttttc ttgcagtgtc atgcacgagg ccctgcacaa tcattacacc     1740

cagaagtcac tgagcctgtc cccaggaaag                                      1770


<210>  48
<211>  2493
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Squence nuclique codant GPAD2-scFcL (SEQ ID NO:35)

<400>  48
agcaataagt ataaagacgg ggatcagtgc gagacctccc catgtcagaa ccagggcaag       60

tgcaaagacg ggctgggaga gtacacatgc acttgtctgg aggggttcga aggaaagaat      120

tgcgaactgt ttacaagaaa gctgtgcagc ctggataacg gcgactgcga tcagttctgt      180

cacgaggaac agaatagtgt ggtctgctca tgtgccaggg ggtacactct ggctgacaac      240

ggaaaggcat gcatccctac tggaccttat ccatgtggca aacagaccct ggagcggaga      300

aagaggcgca aacgcatcgt gggcgggcag gagtgcaagg atggagaatg tccatggcag      360

gctctgctga ttaacgagga aaatgagggc ttctgcggag gcacaatcct gagcgagttc      420

tacattctga ctgccgctca ttgtctgtat caggctaagc ggttcaaggt gcgggtcggc      480

gacagaaaca ccgagcagga ggaaggggga gaagcagtgc acgaggtcga agtggtcatc      540

aagcataatc gcttcacaaa agagacttac gactttgata tcgccgtgct gagactgaag      600

acccccatta cattcaggat gaatgtggca ccagcatgcc tgcctgagcg agattgggct      660

gaatcaactc tgatgaccca gaaaacagga attgtgagcg gctttgggcg aactcacgag      720

aagggcaggc agagcacccg cctgaaaatg ctggaagtgc cctacgtcga ccggaacagc      780

tgtaagctga gctcctcttt catcattacc cagaatatgt tttgcgccgg ctatgacaca      840

aagcaggagg atgcttgtca gggggactcc ggaggacctc atgtgaccag attcaaagat      900

acatattttg tgactggcat cgtctcttgg ggagaaggct gcgccaggaa gggcaaatac      960

gggatctata ctaaggtgac cgccttcctg aaatggattg atcgatccat gaagactcgg     1020

ggcctgccaa aggcaaaatc tcacgccccc gaagtgatca ccagttcacc tctgaaggac     1080

aaaacccata catgcccacc ttgtccagca cctgaactgc tgggaggacc atccgtgttc     1140

ctgtttccac ccaagcccaa agatacactg atgattagtc ggacccctga ggtgacatgc     1200

gtggtcgtgg atgtctcaca cgaggaccca gaagtgaagt ttaactggta cgtggacggc     1260

gtggaagtcc ataatgccaa gaccaaacct cgcgaggaac agtacaacag tacatatcga     1320

gtcgtgtcag tgctgactgt cctgcaccag gattggctga acggaaagga gtataagtgc     1380

aaagtgagca ataaggctct gccagcaccc atcgagaaaa caatttccaa ggcaaaaggc     1440

cagccaaggg aaccccaggt gtacactctg cctccaagcc gcgatgagct gacaaagaac     1500

caggtgtccc tgacttgtct ggtcaaaggg ttctatccct ccgacatcgc cgtggagtgg     1560

gaatctaatg gacagcctga gaacaattac aagaccacac cccctgtgct ggactcagat     1620

gggagcttct ttctgtattc taagctgact gtggacaaaa gtagatggca gcagggaaac     1680

gtgttttctt gcagtgtcat gcacgaggcc ctgcacaatc attacaccca gaagtcactg     1740

agcctgtccc caggaggagg aggaggaagc ggaggaggag gctccggggg aggcgggtct     1800

gagcccaaga gctccgataa aactcatacc tgcccaccct gtcctgctcc agaactgctg     1860

ggaggcccta gcgtgttcct gtttcctcca aagccaaaag acacactgat gatttctagg     1920

actcccgagg tgacctgcgt ggtggtcgat gtcagtcacg aggaccctga agtgaagttc     1980

aactggtacg tggatggagt cgaggtgcac aacgccaaga ccaaaccccg ggaggaacag     2040

tacaacagca cctatagagt ggtctccgtg ctgacagtcc tgcaccagga ctggctgaac     2100

gggaaggaat acaagtgcaa agtgtccaat aaggccctgc ccgctcctat cgaaaaaacc     2160

atttctaagg ctaaaggcca gccccgggag ccacaggtgt acacactgcc cccttctcgg     2220

gatgaactga ccaagaacca ggtgagtctg acatgtctgg tcaaaggctt ctatccaagt     2280

gacatcgcag tggagtggga atcaaatggg cagcccgaga acaattacaa gactacccca     2340

cccgtgctgg actccgatgg ctctttcttt ctgtattcaa agctgaccgt ggacaaaagc     2400

agatggcagc aggggaacgt gttcagctgc agtgtcatgc acgaagcact gcacaatcat     2460

tacactcaga aatcactgtc actgtcacct gga                                  2493


<210>  49
<211>  2463
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Squence nuclique codant GPAD2-scFcS (SEQ ID NO:36)

<400>  49
agcaataagt ataaagacgg ggatcagtgc gagacctccc catgtcagaa ccagggcaag       60

tgcaaagacg ggctgggaga gtacacatgc acttgtctgg aggggttcga aggaaagaat      120

tgcgaactgt ttacaagaaa gctgtgcagc ctggataacg gcgactgcga tcagttctgt      180

cacgaggaac agaatagtgt ggtctgctca tgtgccaggg ggtacactct ggctgacaac      240

ggaaaggcat gcatccctac tggaccttat ccatgtggca aacagaccct ggagcggaga      300

aagaggcgca aacgcatcgt gggcgggcag gagtgcaagg atggagaatg tccatggcag      360

gctctgctga ttaacgagga aaatgagggc ttctgcggag gcacaatcct gagcgagttc      420

tacattctga ctgccgctca ttgtctgtat caggctaagc ggttcaaggt gcgggtcggc      480

gacagaaaca ccgagcagga ggaaggggga gaagcagtgc acgaggtcga agtggtcatc      540

aagcataatc gcttcacaaa agagacttac gactttgata tcgccgtgct gagactgaag      600

acccccatta cattcaggat gaatgtggca ccagcatgcc tgcctgagcg agattgggct      660

gaatcaactc tgatgaccca gaaaacagga attgtgagcg gctttgggcg aactcacgag      720

aagggcaggc agagcacccg cctgaaaatg ctggaagtgc cctacgtcga ccggaacagc      780

tgtaagctga gctcctcttt catcattacc cagaatatgt tttgcgccgg ctatgacaca      840

aagcaggagg atgcttgtca gggggactcc ggaggacctc atgtgaccag attcaaagat      900

acatattttg tgactggcat cgtctcttgg ggagaaggct gcgccaggaa gggcaaatac      960

gggatctata ctaaggtgac cgccttcctg aaatggattg atcgatccat gaagactcgg     1020

ggcctgccaa aggcaaaatc tcacgccccc gaagtgatca ccagttcacc tctgaaggac     1080

aaaacccata catgcccacc ttgtccagca cctgaactgc tgggaggacc atccgtgttc     1140

ctgtttccac ccaagcccaa agatacactg atgattagtc ggacccctga ggtgacatgc     1200

gtggtcgtgg atgtctcaca cgaggaccca gaagtgaagt ttaactggta cgtggacggc     1260

gtggaagtcc ataatgccaa gaccaaacct cgcgaggaac agtacaacag tacatatcga     1320

gtcgtgtcag tgctgactgt cctgcaccag gattggctga acggaaagga gtataagtgc     1380

aaagtgagca ataaggctct gccagcaccc atcgagaaaa caatttccaa ggcaaaaggc     1440

cagccaaggg aaccccaggt gtacactctg cctccaagcc gcgatgagct gacaaagaac     1500

caggtgtccc tgacttgtct ggtcaaaggg ttctatccct ccgacatcgc cgtggagtgg     1560

gaatctaatg gacagcctga gaacaattac aagaccacac cccctgtgct ggactcagat     1620

gggagcttct ttctgtattc taagctgact gtggacaaaa gtagatggca gcagggaaac     1680

gtgttttctt gcagtgtcat gcacgaggcc ctgcacaatc attacaccca gaagtcactg     1740

agcctgtccc caggaggagg aggaggaagc gagcccaaga gctccgataa aactcatacc     1800

tgcccaccct gtcctgctcc agaactgctg ggaggcccta gcgtgttcct gtttcctcca     1860

aagccaaaag acacactgat gatttctagg actcccgagg tgacctgcgt ggtggtcgat     1920

gtcagtcacg aggaccctga agtgaagttc aactggtacg tggatggagt cgaggtgcac     1980

aacgccaaga ccaaaccccg ggaggaacag tacaacagca cctatagagt ggtctccgtg     2040

ctgacagtcc tgcaccagga ctggctgaac gggaaggaat acaagtgcaa agtgtccaat     2100

aaggccctgc ccgctcctat cgaaaaaacc atttctaagg ctaaaggcca gccccgggag     2160

ccacaggtgt acacactgcc cccttctcgg gatgaactga ccaagaacca ggtgagtctg     2220

acatgtctgg tcaaaggctt ctatccaagt gacatcgcag tggagtggga atcaaatggg     2280

cagcccgaga acaattacaa gactacccca cccgtgctgg actccgatgg ctctttcttt     2340

ctgtattcaa agctgaccgt ggacaaaagc agatggcagc aggggaacgt gttcagctgc     2400

agtgtcatgc acgaagcact gcacaatcat tacactcaga aatcactgtc actgtcacct     2460

gga                                                                   2463


<210>  50
<211>  2505
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Squence nuclique codant scFcL-GPAD2 (SEQ ID NO:37)

<400>  50
gataagacac acacttgccc accctgccct gcccctgagc tgctgggcgg gccaagcgtg       60

ttcctgtttc cccctaagcc aaaagataca ctgatgatca gtagaactcc cgaagtgacc      120

tgcgtggtcg tggacgtctc acacgaggac cccgaagtga agttcaactg gtacgtggac      180

ggcgtggagg tccataatgc caagaccaaa ccccgcgagg aacagtacaa ctccacctat      240

cgagtcgtgt ctgtgctgac agtcctgcac caggattggc tgaacggcaa ggagtataag      300

tgcaaagtgt ctaataaggc tctgccagca cccatcgaga aaaccattag taaggcaaaa      360

gggcagccta gggaaccaca ggtgtacaca ctgccaccca gtcgcgatga gctgactaag      420

aaccaggtgt cactgacctg tctggtcaaa ggattctatc cttcagacat cgccgtggag      480

tgggaaagca atggccagcc agagaacaat tacaagacca cacctccagt gctggactct      540

gatggaagtt tctttctgta tagcaagctg actgtggaca aatccagatg gcagcagggc      600

aacgtgtttt cttgcagtgt catgcacgag gccctgcaca atcattacac ccagaagtca      660

ctgagcctgt cccctggagg aggaggaggc agtggaggag gagggtcagg aggcggggga      720

agcgagccaa agagctccga taaaacacat acttgccccc cttgtcctgc tccagaactg      780

ctgggaggac cttccgtgtt cctgtttcca cccaagccta aagacacact gatgatttcc      840

aggacaccag aagtgacttg tgtcgtggtc gacgtgtctc atgaggaccc cgaggtgaag      900

tttaactggt acgtggatgg agtcgaagtg cacaacgcca agaccaaacc ccgggaggaa      960

cagtacaata gtacttatag agtggtctca gtgctgaccg tcctgcacca ggactggctg     1020

aatggcaagg aatataagtg caaagtgagc aataaggccc tgcccgctcc tatcgaaaaa     1080

actatttcca aggctaaagg ccagccccga gagcctcagg tgtacaccct gcctccaagc     1140

cgggatgaac tgacaaagaa ccaggtgtcc ctgacttgtc tggtcaaagg gttctatccc     1200

tccgacatcg cagtggagtg ggaatctaat ggacagcctg agaacaatta caagactacc     1260

ccccctgtgc tggactcaga tgggagcttc tttctgtatt ctaagctgac cgtggataaa     1320

agtcgctggc agcagggaaa tgtgttttct tgtagtgtca tgcacgaagc cctgcataac     1380

cactatactc aaaagtcact gagcctgagc ccaggaggag gaggaggctc caacaagtat     1440

aaagacgggg atcagtgcga gacatctcct tgtcagaatc agggaaagtg taaagacggc     1500

ctgggggagt acacctgcac atgtctggag ggcttcgaag ggaagaactg cgaactgttt     1560

acaagaaaac tgtgtagcct ggataacggc gactgcgatc agttctgtca tgaggaacag     1620

aattccgtgg tctgctcttg tgccaggggc tacaccctgg ctgacaatgg gaaggcatgc     1680

atccctaccg ggccatatcc ctgtggaaaa cagacactgg agcggagaaa gaggcgcaaa     1740

cggatcgtgg ggggacagga gtgcaaggat ggcgaatgtc catggcaggc tctgctgatt     1800

aacgaggaaa atgaggggtt ctgcggcggg actatcctgt ccgaatttta cattctgacc     1860

gccgctcact gtctgtatca ggctaagcgg ttcaaggtgc gggtcggcga cagaaacacc     1920

gagcaggagg aaggaggcga agcagtgcac gaggtcgaag tggtcatcaa gcataatcgc     1980

ttcactaaag agacctacga ctttgatatc gccgtgctga gactgaagac acccattact     2040

ttcaggatga acgtggcacc agcatgcctg ccagagcgag attgggctga atctaccctg     2100

atgacacaga aaactggcat tgtgagtgga tttggccgaa cacatgagaa ggggaggcag     2160

tctactcgcc tgaaaatgct ggaagtgccc tacgtcgacc ggaactcctg taagctgtct     2220

agttcattca tcatcacaca gaacatgttt tgcgccggat atgacactaa gcaggaagat     2280

gcttgtcagg gcgacagcgg aggacctcac gtgaccagat tcaaagatac ctattttgtg     2340

acaggcatcg tctcctgggg ggagggatgc gcaaggaagg gaaaatacgg catctatacc     2400

aaggtgacag ccttcctgaa atggattgac cgatcaatga agacacgggg cctgcccaag     2460

gcaaaaagcc atgcccctga agtgatcact agctccccac tgaaa                     2505


<210>  51
<211>  2496
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Squence nuclique codant scFcL-GPAD1 (SEQ ID NO:38)

<400>  51
gataagacac acacttgccc accctgccct gcccctgagc tgctgggcgg gccaagcgtg       60

ttcctgtttc cccctaagcc aaaagataca ctgatgatca gtagaactcc cgaagtgacc      120

tgcgtggtcg tggacgtctc acacgaggac cccgaagtga agttcaactg gtacgtggac      180

ggcgtggagg tccataatgc caagaccaaa ccccgcgagg aacagtacaa ctccacctat      240

cgagtcgtgt ctgtgctgac agtcctgcac caggattggc tgaacggcaa ggagtataag      300

tgcaaagtgt ctaataaggc tctgccagca cccatcgaga aaaccattag taaggcaaaa      360

gggcagccta gggaaccaca ggtgtacaca ctgccaccca gtcgcgatga gctgactaag      420

aaccaggtgt cactgacctg tctggtcaaa ggattctatc cttcagacat cgccgtggag      480

tgggaaagca atggccagcc agagaacaat tacaagacca cacctccagt gctggactct      540

gatggaagtt tctttctgta tagcaagctg actgtggaca aatccagatg gcagcagggc      600

aacgtgtttt cttgcagtgt catgcacgag gccctgcaca atcattacac ccagaagtca      660

ctgagcctgt cccctggagg aggaggaggc agtggaggag gagggtcagg aggcggggga      720

agcgagccaa agagctccga taaaacacat acttgccccc cttgtcctgc tccagaactg      780

ctgggaggac cttccgtgtt cctgtttcca cccaagccta aagacacact gatgatttcc      840

aggacaccag aagtgacttg tgtcgtggtc gacgtgtctc atgaggaccc cgaggtgaag      900

tttaactggt acgtggatgg agtcgaagtg cacaacgcca agaccaaacc ccgggaggaa      960

cagtacaata gtacttatag agtggtctca gtgctgaccg tcctgcacca ggactggctg     1020

aatggcaagg aatataagtg caaagtgagc aataaggccc tgcccgctcc tatcgaaaaa     1080

actatttcca aggctaaagg ccagccccga gagcctcagg tgtacaccct gcctccaagc     1140

cgggatgaac tgacaaagaa ccaggtgtcc ctgacttgtc tggtcaaagg gttctatccc     1200

tccgacatcg cagtggagtg ggaatctaat ggacagcctg agaacaatta caagactacc     1260

ccccctgtgc tggactcaga tgggagcttc tttctgtatt ctaagctgac cgtggataaa     1320

agtcgctggc agcagggaaa tgtgttttct tgtagtgtca tgcacgaagc cctgcataac     1380

cactatactc aaaagtcact gagcctgagc ccaggaggag gaggaggctc caacaagtat     1440

aaagacgggg atcagtgcga gacatctcct tgtcagaatc agggaaagtg taaagacggc     1500

ctgggggagt acacctgcac atgtctggag ggcttcgaag ggaagaactg cgaactgttt     1560

acaagaaaac tgtgtagcct ggataacggc gactgcgatc agttctgtca tgaggaacag     1620

aattccgtgg tctgctcttg tgccaggggc tacaccctgg ctgacaatgg gaaggcatgc     1680

atccctaccg ggccatatcc ctgtggaaaa cagacactgg agcggagaaa gaggatcgtg     1740

gggggacagg agtgcaagga tggcgaatgt ccatggcagg ctctgctgat taacgaggaa     1800

aatgaggggt tctgcggcgg gactatcctg tccgaatttt acattctgac cgccgctcac     1860

tgtctgtatc aggctaagcg gttcaaggtg cgggtcggcg acagaaacac cgagcaggag     1920

gaaggaggcg aagcagtgca cgaggtcgaa gtggtcatca agcataatcg cttcactaaa     1980

gagacctacg actttgatat cgccgtgctg agactgaaga cacccattac tttcaggatg     2040

aacgtggcac cagcatgcct gccagagcga gattgggctg aatctaccct gatgacacag     2100

aaaactggca ttgtgagtgg atttggccga acacatgaga aggggaggca gtctactcgc     2160

ctgaaaatgc tggaagtgcc ctacgtcgac cggaactcct gtaagctgtc tagttcattc     2220

atcatcacac agaacatgtt ttgcgccgga tatgacacta agcaggaaga tgcttgtcag     2280

ggcgacagcg gaggacctca cgtgaccaga ttcaaagata cctattttgt gacaggcatc     2340

gtctcctggg gggagggatg cgcaaggaag ggaaaatacg gcatctatac caaggtgaca     2400

gccttcctga aatggattga ccgatcaatg aagacacggg gcctgcccaa ggcaaaaagc     2460

catgcccctg aagtgatcac tagctcccca ctgaaa                               2496


<210>  52
<211>  364
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Exemple de GPAD3

<400>  52

Asn Lys Tyr Lys Asp Gly Asp Gln Cys Glu Thr Ser Pro Cys Gln Asn 
1               5                   10                  15      


Gln Gly Lys Cys Lys Asp Gly Leu Gly Glu Tyr Thr Cys Thr Cys Leu 
            20                  25                  30          


Glu Gly Phe Glu Gly Lys Asn Cys Glu Leu Phe Thr Arg Lys Leu Cys 
        35                  40                  45              


Ser Leu Asp Asn Gly Asp Cys Asp Gln Phe Cys His Glu Glu Gln Asn 
    50                  55                  60                  


Ser Val Val Cys Ser Cys Ala Arg Gly Tyr Thr Leu Ala Asp Asn Gly 
65                  70                  75                  80  


Lys Ala Cys Ile Pro Thr Gly Pro Tyr Pro Cys Gly Lys Gln Thr Leu 
                85                  90                  95      


Glu Arg Gly Gly Gly Gly Ser Arg Arg Lys Arg Arg Lys Arg Ile Val 
            100                 105                 110         


Gly Gly Gln Glu Cys Lys Asp Gly Glu Cys Pro Trp Gln Ala Leu Leu 
        115                 120                 125             


Ile Asn Glu Glu Asn Glu Gly Phe Cys Gly Gly Thr Ile Leu Ser Glu 
    130                 135                 140                 


Phe Tyr Ile Leu Thr Ala Ala His Cys Leu Tyr Gln Ala Lys Arg Phe 
145                 150                 155                 160 


Lys Val Arg Val Gly Asp Arg Asn Thr Glu Gln Glu Glu Gly Gly Glu 
                165                 170                 175     


Ala Val His Glu Val Glu Val Val Ile Lys His Asn Arg Phe Thr Lys 
            180                 185                 190         


Glu Thr Tyr Asp Phe Asp Ile Ala Val Leu Arg Leu Lys Thr Pro Ile 
        195                 200                 205             


Thr Phe Arg Met Asn Val Ala Pro Ala Cys Leu Pro Glu Arg Asp Trp 
    210                 215                 220                 


Ala Glu Ser Thr Leu Met Thr Gln Lys Thr Gly Ile Val Ser Gly Phe 
225                 230                 235                 240 


Gly Arg Thr His Glu Lys Gly Arg Gln Ser Thr Arg Leu Lys Met Leu 
                245                 250                 255     


Glu Val Pro Tyr Val Asp Arg Asn Ser Cys Lys Leu Ser Ser Ser Phe 
            260                 265                 270         


Ile Ile Thr Gln Asn Met Phe Cys Ala Gly Tyr Asp Thr Lys Gln Glu 
        275                 280                 285             


Asp Ala Cys Gln Gly Asp Ser Gly Gly Pro His Val Thr Arg Phe Lys 
    290                 295                 300                 


Asp Thr Tyr Phe Val Thr Gly Ile Val Ser Trp Gly Glu Gly Cys Ala 
305                 310                 315                 320 


Arg Lys Gly Lys Tyr Gly Ile Tyr Thr Lys Val Thr Ala Phe Leu Lys 
                325                 330                 335     


Trp Ile Asp Arg Ser Met Lys Thr Arg Gly Leu Pro Lys Ala Lys Ser 
            340                 345                 350         


His Ala Pro Glu Val Ile Thr Ser Ser Pro Leu Lys 
        355                 360                 


<210>  53
<211>  360
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Exemple de GPAD3

<400>  53

Asn Lys Tyr Lys Asp Gly Asp Gln Cys Glu Thr Ser Pro Cys Gln Asn 
1               5                   10                  15      


Gln Gly Lys Cys Lys Asp Gly Leu Gly Glu Tyr Thr Cys Thr Cys Leu 
            20                  25                  30          


Glu Gly Phe Glu Gly Lys Asn Cys Glu Leu Phe Thr Arg Lys Leu Cys 
        35                  40                  45              


Ser Leu Asp Asn Gly Asp Cys Asp Gln Phe Cys His Glu Glu Gln Asn 
    50                  55                  60                  


Ser Val Val Cys Ser Cys Ala Arg Gly Tyr Thr Leu Ala Asp Asn Gly 
65                  70                  75                  80  


Lys Ala Cys Ile Pro Thr Gly Pro Tyr Pro Cys Gly Lys Gln Thr Leu 
                85                  90                  95      


Glu Arg Gly Ser Ser Gly Arg Arg Lys Arg Ile Val Gly Gly Gln Glu 
            100                 105                 110         


Cys Lys Asp Gly Glu Cys Pro Trp Gln Ala Leu Leu Ile Asn Glu Glu 
        115                 120                 125             


Asn Glu Gly Phe Cys Gly Gly Thr Ile Leu Ser Glu Phe Tyr Ile Leu 
    130                 135                 140                 


Thr Ala Ala His Cys Leu Tyr Gln Ala Lys Arg Phe Lys Val Arg Val 
145                 150                 155                 160 


Gly Asp Arg Asn Thr Glu Gln Glu Glu Gly Gly Glu Ala Val His Glu 
                165                 170                 175     


Val Glu Val Val Ile Lys His Asn Arg Phe Thr Lys Glu Thr Tyr Asp 
            180                 185                 190         


Phe Asp Ile Ala Val Leu Arg Leu Lys Thr Pro Ile Thr Phe Arg Met 
        195                 200                 205             


Asn Val Ala Pro Ala Cys Leu Pro Glu Arg Asp Trp Ala Glu Ser Thr 
    210                 215                 220                 


Leu Met Thr Gln Lys Thr Gly Ile Val Ser Gly Phe Gly Arg Thr His 
225                 230                 235                 240 


Glu Lys Gly Arg Gln Ser Thr Arg Leu Lys Met Leu Glu Val Pro Tyr 
                245                 250                 255     


Val Asp Arg Asn Ser Cys Lys Leu Ser Ser Ser Phe Ile Ile Thr Gln 
            260                 265                 270         


Asn Met Phe Cys Ala Gly Tyr Asp Thr Lys Gln Glu Asp Ala Cys Gln 
        275                 280                 285             


Gly Asp Ser Gly Gly Pro His Val Thr Arg Phe Lys Asp Thr Tyr Phe 
    290                 295                 300                 


Val Thr Gly Ile Val Ser Trp Gly Glu Gly Cys Ala Arg Lys Gly Lys 
305                 310                 315                 320 


Tyr Gly Ile Tyr Thr Lys Val Thr Ala Phe Leu Lys Trp Ile Asp Arg 
                325                 330                 335     


Ser Met Lys Thr Arg Gly Leu Pro Lys Ala Lys Ser His Ala Pro Glu 
            340                 345                 350         


Val Ile Thr Ser Ser Pro Leu Lys 
        355                 360 


<210>  54
<211>  231
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  SEQ ID NO:39 comprenant la rgion charnire entire en N-terminal

<400>  54

Glu Pro Lys Ser Cys Asp Lys Thr His Thr Cys Pro Pro Cys Pro Ala 
1               5                   10                  15      


Pro Glu Leu Leu Gly Gly Pro Ser Val Phe Leu Phe Pro Pro Lys Pro 
            20                  25                  30          


Lys Asp Thr Leu Met Ile Ser Arg Thr Pro Glu Val Thr Cys Val Val 
        35                  40                  45              


Val Asp Val Ser His Glu Asp Pro Glu Val Lys Phe Asn Trp Tyr Val 
    50                  55                  60                  


Asp Gly Val Glu Val His Asn Ala Lys Thr Lys Pro Arg Glu Glu Gln 
65                  70                  75                  80  


Tyr Asn Ser Thr Tyr Arg Val Val Ser Val Leu Thr Val Leu His Gln 
                85                  90                  95      


Asp Trp Leu Asn Gly Lys Glu Tyr Lys Cys Lys Val Ser Asn Lys Ala 
            100                 105                 110         


Leu Pro Ala Pro Ile Glu Lys Thr Ile Ser Lys Ala Lys Gly Gln Pro 
        115                 120                 125             


Arg Glu Pro Gln Val Tyr Thr Leu Pro Pro Ser Arg Asp Glu Leu Thr 
    130                 135                 140                 


Lys Asn Gln Val Ser Leu Thr Cys Leu Val Lys Gly Phe Tyr Pro Ser 
145                 150                 155                 160 


Asp Ile Ala Val Glu Trp Glu Ser Asn Gly Gln Pro Glu Asn Asn Tyr 
                165                 170                 175     


Lys Thr Thr Pro Pro Val Leu Asp Ser Asp Gly Ser Phe Phe Leu Tyr 
            180                 185                 190         


Ser Lys Leu Thr Val Asp Lys Ser Arg Trp Gln Gln Gly Asn Val Phe 
        195                 200                 205             


Ser Cys Ser Val Met His Glu Ala Leu His Asn His Tyr Thr Gln Lys 
    210                 215                 220                 


Ser Leu Ser Leu Ser Pro Gly 
225                 230     


<210>  55
<211>  10
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Rgion charnire partielle N-terminal

<400>  55

Asp Lys Thr His Thr Cys Pro Pro Cys Pro 
1               5                   10  


<210>  56
<211>  15
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Rgion charnire entire N-terminal

<400>  56

Glu Pro Lys Ser Cys Asp Lys Thr His Thr Cys Pro Pro Cys Pro 
1               5                   10                  15  


<210>  57
<211>  1080
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Squence nuclique codant pour GPAD3-LC (SEQ ID NO:28)

<400>  57
aacaagtaca aggacgggga ccagtgtgag acctcccctt gccagaacca gggcaagtgt       60

aaagatggac tgggcgagta cacctgcaca tgtctggagg gattcgaagg caagaattgc      120

gaactgttta ctagaaaact gtgttctctg gataacgggg actgcgatca gttctgtcac      180

gaggaacaga attccgtggt ctgctcttgt gccagggggt acaccctggc cgacaacgga      240

aaggcttgca tccctaccgg accctatcct tgtggcaaac agacactgga gcgagggagc      300

tccggacgaa gaaagcgaat cgtgggagga caggagtgca aagatgggga atgtccatgg      360

caggccctgc tgattaacga ggaaaatgag ggattctgcg gaggcactat cctgagcgaa      420

ttttacattc tgaccgccgc tcattgtctg tatcaggcca agaggtttaa agtgcgcgtc      480

ggcgaccgaa acacagagca ggaggaaggg ggagaagctg tgcacgaggt cgaagtggtc      540

atcaagcata atcgcttcac taaagagacc tacgactttg atatcgcagt gctgagactg      600

aagacaccaa ttactttcag gatgaatgtc gcaccagcat gcctgccaga gcgagattgg      660

gctgaaagta ccctgatgac acagaagact ggaattgtgt cagggtttgg acggacacac      720

gagaagggcc ggcagtctac tagactgaaa atgctggaag tgccctacgt cgacaggaac      780

agttgtaagc tgtctagttc attcatcatc acacagaaca tgttttgcgc aggctatgac      840

actaagcagg aggatgcctg tcagggggac agcggaggac ctcacgtgac ccgcttcaaa      900

gatacttatt ttgtgaccgg aatcgtcagc tggggagagg gatgcgctcg aaagggcaaa      960

tacgggatct ataccaaggt gacagcattc ctgaaatgga ttgacaggag catgaagacc     1020

cgcggcctgc ctaaggctaa atcccatgca ccagaagtga tcacaagctc ccccctgaag     1080


<210>  58
<211>  1098
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Squence nuclique codant pour GPAD3-LL (SEQ ID NO:29)

<400>  58
aacaagtata aagacggaga ccagtgcgag acatcccctt gccagaacca gggcaagtgt       60

aaagatgggc tgggagagta cacctgcaca tgtctggagg ggttcgaagg aaagaattgc      120

gaactgttta ctagaaaact gtgttctctg gataacgggg actgcgatca gttctgtcac      180

gaggaacaga attcagtggt ctgcagctgt gccagggggt acaccctggc cgacaacgga      240

aaggcttgca tccccaccgg accctatcct tgtggcaaac agacactgga gagaggagga      300

ggaggatccg gaggaggagg gtctcggaga aagaggatcg tgggaggcca ggagtgcaaa      360

gatggggaat gtccttggca ggccctgctg attaacgagg aaaatgaggg attctgcggg      420

ggaactatcc tgagcgaatt ttacattctg accgccgctc actgtctgta tcaggccaag      480

aggtttaaag tgcgcgtcgg cgaccgaaac acagagcagg aggaaggcgg ggaagctgtg      540

cacgaggtcg aagtggtcat caagcataat cgcttcacta aagagaccta cgactttgat      600

atcgcagtgc tgcgactgaa gacaccaatt actttccgga tgaatgtcgc accagcatgc      660

ctgccagagc gagattgggc tgaaagtacc ctgatgacac agaagactgg aattgtgtca      720

ggctttgggc ggacacatga gaagggccgg cagtctacta gactgaaaat gctggaagtg      780

ccttacgtcg acaggaacag ttgtaagctg agctcctctt tcatcattac acagaatatg      840

ttttgcgcag gctatgacac taagcaggag gatgcatgtc agggggacag cggaggacca      900

cacgtgaccc gcttcaaaga tacttatttt gtgaccggaa tcgtcagctg gggagaggga      960

tgcgctcgaa agggcaaata cgggatctat accaaggtga cagcattcct gaaatggatt     1020

gacaggagca tgaagacccg cggcctgcct aaggctaaat cccatgcacc agaagtgatc     1080

acaagttcac ccctgaag                                                   1098


<210>  59
<211>  1107
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Squence nuclique codant pour GPAD3-2F (SEQ ID NO:30)

<400>  59
aacaagtaca aggacgggga tcagtgcgag acctcccctt gccagaacca gggcaagtgt       60

aaagatgggc tgggagagta cacctgcaca tgtctggagg ggttcgaagg aaagaattgc      120

gaactgttta ctcgcaaact gtgttctctg gataacgggg actgcgatca gttctgtcac      180

gaggaacaga attcagtggt ctgcagctgt gccagaggct acaccctggc cgacaacgga      240

aaggcttgca tccccaccgg accctatcct tgtggcaagc agacactgga gcgaagaaaa      300

cgaggaggag gaggatccgg aggaggaggg tctaggcgca agcgaatcgt gggaggccag      360

gagtgcaaag atggggaatg tccttggcag gccctgctga ttaacgagga aaatgaggga      420

ttctgcgggg gaactatcct gagcgaattt tacattctga ccgccgctca ctgtctgtat      480

caggccaagc ggttcaaggt gcgggtcggc gacagaaaca cagagcagga ggaaggcggg      540

gaagctgtgc acgaggtcga agtggtcatc aagcataata gattcactaa agagacctac      600

gactttgata tcgcagtgct gagactgaag acaccaatta ctttcaggat gaatgtcgca      660

ccagcctgcc tgcccgagag agattgggct gaaagtaccc tgatgacaca gaaaactgga      720

attgtgtcag gctttgggag gacacatgag aagggcaggc agtctactcg cctgaaaatg      780

ctggaagtgc cttacgtcga caggaacagt tgtaagctga gctcctcttt catcattaca      840

cagaatatgt tttgcgcagg ctatgacact aagcaggagg atgcatgtca gggggacagc      900

ggaggaccac acgtgacccg cttcaaagat acttattttg tgaccggaat cgtcagctgg      960

ggagagggat gcgctcgaaa gggcaaatac gggatctata ccaaggtgac agcattcctg     1020

aaatggattg accgaagcat gaagacccgg ggcctgccta aggctaaatc ccatgcacca     1080

gaagtgatca caagttcacc cctgaag                                         1107


<210>  60
<211>  374
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  GPAD1 avec peptide signal MB7

<400>  60

Met Arg Trp Ser Trp Ile Phe Leu Leu Leu Leu Ser Ile Thr Ser Ala 
1               5                   10                  15      


Asn Ala Ser Asn Lys Tyr Lys Asp Gly Asp Gln Cys Glu Thr Ser Pro 
            20                  25                  30          


Cys Gln Asn Gln Gly Lys Cys Lys Asp Gly Leu Gly Glu Tyr Thr Cys 
        35                  40                  45              


Thr Cys Leu Glu Gly Phe Glu Gly Lys Asn Cys Glu Leu Phe Thr Arg 
    50                  55                  60                  


Lys Leu Cys Ser Leu Asp Asn Gly Asp Cys Asp Gln Phe Cys His Glu 
65                  70                  75                  80  


Glu Gln Asn Ser Val Val Cys Ser Cys Ala Arg Gly Tyr Thr Leu Ala 
                85                  90                  95      


Asp Asn Gly Lys Ala Cys Ile Pro Thr Gly Pro Tyr Pro Cys Gly Lys 
            100                 105                 110         


Gln Thr Leu Glu Arg Arg Lys Arg Ile Val Gly Gly Gln Glu Cys Lys 
        115                 120                 125             


Asp Gly Glu Cys Pro Trp Gln Ala Leu Leu Ile Asn Glu Glu Asn Glu 
    130                 135                 140                 


Gly Phe Cys Gly Gly Thr Ile Leu Ser Glu Phe Tyr Ile Leu Thr Ala 
145                 150                 155                 160 


Ala His Cys Leu Tyr Gln Ala Lys Arg Phe Lys Val Arg Val Gly Asp 
                165                 170                 175     


Arg Asn Thr Glu Gln Glu Glu Gly Gly Glu Ala Val His Glu Val Glu 
            180                 185                 190         


Val Val Ile Lys His Asn Arg Phe Thr Lys Glu Thr Tyr Asp Phe Asp 
        195                 200                 205             


Ile Ala Val Leu Arg Leu Lys Thr Pro Ile Thr Phe Arg Met Asn Val 
    210                 215                 220                 


Ala Pro Ala Cys Leu Pro Glu Arg Asp Trp Ala Glu Ser Thr Leu Met 
225                 230                 235                 240 


Thr Gln Lys Thr Gly Ile Val Ser Gly Phe Gly Arg Thr His Glu Lys 
                245                 250                 255     


Gly Arg Gln Ser Thr Arg Leu Lys Met Leu Glu Val Pro Tyr Val Asp 
            260                 265                 270         


Arg Asn Ser Cys Lys Leu Ser Ser Ser Phe Ile Ile Thr Gln Asn Met 
        275                 280                 285             


Phe Cys Ala Gly Tyr Asp Thr Lys Gln Glu Asp Ala Cys Gln Gly Asp 
    290                 295                 300                 


Ser Gly Gly Pro His Val Thr Arg Phe Lys Asp Thr Tyr Phe Val Thr 
305                 310                 315                 320 


Gly Ile Val Ser Trp Gly Glu Gly Cys Ala Arg Lys Gly Lys Tyr Gly 
                325                 330                 335     


Ile Tyr Thr Lys Val Thr Ala Phe Leu Lys Trp Ile Asp Arg Ser Met 
            340                 345                 350         


Lys Thr Arg Gly Leu Pro Lys Ala Lys Ser His Ala Pro Glu Val Ile 
        355                 360                 365             


Thr Ser Ser Pro Leu Lys 
    370                 


<210>  61
<211>  377
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  GPAD2 avec peptide signal MB7

<400>  61

Met Arg Trp Ser Trp Ile Phe Leu Leu Leu Leu Ser Ile Thr Ser Ala 
1               5                   10                  15      


Asn Ala Ser Asn Lys Tyr Lys Asp Gly Asp Gln Cys Glu Thr Ser Pro 
            20                  25                  30          


Cys Gln Asn Gln Gly Lys Cys Lys Asp Gly Leu Gly Glu Tyr Thr Cys 
        35                  40                  45              


Thr Cys Leu Glu Gly Phe Glu Gly Lys Asn Cys Glu Leu Phe Thr Arg 
    50                  55                  60                  


Lys Leu Cys Ser Leu Asp Asn Gly Asp Cys Asp Gln Phe Cys His Glu 
65                  70                  75                  80  


Glu Gln Asn Ser Val Val Cys Ser Cys Ala Arg Gly Tyr Thr Leu Ala 
                85                  90                  95      


Asp Asn Gly Lys Ala Cys Ile Pro Thr Gly Pro Tyr Pro Cys Gly Lys 
            100                 105                 110         


Gln Thr Leu Glu Arg Arg Lys Arg Arg Lys Arg Ile Val Gly Gly Gln 
        115                 120                 125             


Glu Cys Lys Asp Gly Glu Cys Pro Trp Gln Ala Leu Leu Ile Asn Glu 
    130                 135                 140                 


Glu Asn Glu Gly Phe Cys Gly Gly Thr Ile Leu Ser Glu Phe Tyr Ile 
145                 150                 155                 160 


Leu Thr Ala Ala His Cys Leu Tyr Gln Ala Lys Arg Phe Lys Val Arg 
                165                 170                 175     


Val Gly Asp Arg Asn Thr Glu Gln Glu Glu Gly Gly Glu Ala Val His 
            180                 185                 190         


Glu Val Glu Val Val Ile Lys His Asn Arg Phe Thr Lys Glu Thr Tyr 
        195                 200                 205             


Asp Phe Asp Ile Ala Val Leu Arg Leu Lys Thr Pro Ile Thr Phe Arg 
    210                 215                 220                 


Met Asn Val Ala Pro Ala Cys Leu Pro Glu Arg Asp Trp Ala Glu Ser 
225                 230                 235                 240 


Thr Leu Met Thr Gln Lys Thr Gly Ile Val Ser Gly Phe Gly Arg Thr 
                245                 250                 255     


His Glu Lys Gly Arg Gln Ser Thr Arg Leu Lys Met Leu Glu Val Pro 
            260                 265                 270         


Tyr Val Asp Arg Asn Ser Cys Lys Leu Ser Ser Ser Phe Ile Ile Thr 
        275                 280                 285             


Gln Asn Met Phe Cys Ala Gly Tyr Asp Thr Lys Gln Glu Asp Ala Cys 
    290                 295                 300                 


Gln Gly Asp Ser Gly Gly Pro His Val Thr Arg Phe Lys Asp Thr Tyr 
305                 310                 315                 320 


Phe Val Thr Gly Ile Val Ser Trp Gly Glu Gly Cys Ala Arg Lys Gly 
                325                 330                 335     


Lys Tyr Gly Ile Tyr Thr Lys Val Thr Ala Phe Leu Lys Trp Ile Asp 
            340                 345                 350         


Arg Ser Met Lys Thr Arg Gly Leu Pro Lys Ala Lys Ser His Ala Pro 
        355                 360                 365             


Glu Val Ile Thr Ser Ser Pro Leu Lys 
    370                 375         


<210>  62
<211>  373
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  GPAD1 optimis avec peptide signal MB7

<400>  62

Met Arg Trp Ser Trp Ile Phe Leu Leu Leu Leu Ser Ile Thr Ser Ala 
1               5                   10                  15      


Asn Ala Asn Lys Tyr Lys Asp Gly Asp Gln Cys Glu Thr Ser Pro Cys 
            20                  25                  30          


Gln Asn Gln Gly Lys Cys Lys Asp Gly Leu Gly Glu Tyr Thr Cys Thr 
        35                  40                  45              


Cys Leu Glu Gly Phe Glu Gly Lys Asn Cys Glu Leu Phe Thr Arg Lys 
    50                  55                  60                  


Leu Cys Ser Leu Asp Asn Gly Asp Cys Asp Gln Phe Cys His Glu Glu 
65                  70                  75                  80  


Gln Asn Ser Val Val Cys Ser Cys Ala Arg Gly Tyr Thr Leu Ala Asp 
                85                  90                  95      


Asn Gly Lys Ala Cys Ile Pro Thr Gly Pro Tyr Pro Cys Gly Lys Gln 
            100                 105                 110         


Thr Leu Glu Arg Arg Lys Arg Ile Val Gly Gly Gln Glu Cys Lys Asp 
        115                 120                 125             


Gly Glu Cys Pro Trp Gln Ala Leu Leu Ile Asn Glu Glu Asn Glu Gly 
    130                 135                 140                 


Phe Cys Gly Gly Thr Ile Leu Ser Glu Phe Tyr Ile Leu Thr Ala Ala 
145                 150                 155                 160 


His Cys Leu Tyr Gln Ala Lys Arg Phe Lys Val Arg Val Gly Asp Arg 
                165                 170                 175     


Asn Thr Glu Gln Glu Glu Gly Gly Glu Ala Val His Glu Val Glu Val 
            180                 185                 190         


Val Ile Lys His Asn Arg Phe Thr Lys Glu Thr Tyr Asp Phe Asp Ile 
        195                 200                 205             


Ala Val Leu Arg Leu Lys Thr Pro Ile Thr Phe Arg Met Asn Val Ala 
    210                 215                 220                 


Pro Ala Cys Leu Pro Glu Arg Asp Trp Ala Glu Ser Thr Leu Met Thr 
225                 230                 235                 240 


Gln Lys Thr Gly Ile Val Ser Gly Phe Gly Arg Thr His Glu Lys Gly 
                245                 250                 255     


Arg Gln Ser Thr Arg Leu Lys Met Leu Glu Val Pro Tyr Val Asp Arg 
            260                 265                 270         


Asn Ser Cys Lys Leu Ser Ser Ser Phe Ile Ile Thr Gln Asn Met Phe 
        275                 280                 285             


Cys Ala Gly Tyr Asp Thr Lys Gln Glu Asp Ala Cys Gln Gly Asp Ser 
    290                 295                 300                 


Gly Gly Pro His Val Thr Arg Phe Lys Asp Thr Tyr Phe Val Thr Gly 
305                 310                 315                 320 


Ile Val Ser Trp Gly Glu Gly Cys Ala Arg Lys Gly Lys Tyr Gly Ile 
                325                 330                 335     


Tyr Thr Lys Val Thr Ala Phe Leu Lys Trp Ile Asp Arg Ser Met Lys 
            340                 345                 350         


Thr Arg Gly Leu Pro Lys Ala Lys Ser His Ala Pro Glu Val Ile Thr 
        355                 360                 365             


Ser Ser Pro Leu Lys 
    370             


<210>  63
<211>  376
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  GPAD2 optimis avec peptide signal MB7

<400>  63

Met Arg Trp Ser Trp Ile Phe Leu Leu Leu Leu Ser Ile Thr Ser Ala 
1               5                   10                  15      


Asn Ala Asn Lys Tyr Lys Asp Gly Asp Gln Cys Glu Thr Ser Pro Cys 
            20                  25                  30          


Gln Asn Gln Gly Lys Cys Lys Asp Gly Leu Gly Glu Tyr Thr Cys Thr 
        35                  40                  45              


Cys Leu Glu Gly Phe Glu Gly Lys Asn Cys Glu Leu Phe Thr Arg Lys 
    50                  55                  60                  


Leu Cys Ser Leu Asp Asn Gly Asp Cys Asp Gln Phe Cys His Glu Glu 
65                  70                  75                  80  


Gln Asn Ser Val Val Cys Ser Cys Ala Arg Gly Tyr Thr Leu Ala Asp 
                85                  90                  95      


Asn Gly Lys Ala Cys Ile Pro Thr Gly Pro Tyr Pro Cys Gly Lys Gln 
            100                 105                 110         


Thr Leu Glu Arg Arg Lys Arg Arg Lys Arg Ile Val Gly Gly Gln Glu 
        115                 120                 125             


Cys Lys Asp Gly Glu Cys Pro Trp Gln Ala Leu Leu Ile Asn Glu Glu 
    130                 135                 140                 


Asn Glu Gly Phe Cys Gly Gly Thr Ile Leu Ser Glu Phe Tyr Ile Leu 
145                 150                 155                 160 


Thr Ala Ala His Cys Leu Tyr Gln Ala Lys Arg Phe Lys Val Arg Val 
                165                 170                 175     


Gly Asp Arg Asn Thr Glu Gln Glu Glu Gly Gly Glu Ala Val His Glu 
            180                 185                 190         


Val Glu Val Val Ile Lys His Asn Arg Phe Thr Lys Glu Thr Tyr Asp 
        195                 200                 205             


Phe Asp Ile Ala Val Leu Arg Leu Lys Thr Pro Ile Thr Phe Arg Met 
    210                 215                 220                 


Asn Val Ala Pro Ala Cys Leu Pro Glu Arg Asp Trp Ala Glu Ser Thr 
225                 230                 235                 240 


Leu Met Thr Gln Lys Thr Gly Ile Val Ser Gly Phe Gly Arg Thr His 
                245                 250                 255     


Glu Lys Gly Arg Gln Ser Thr Arg Leu Lys Met Leu Glu Val Pro Tyr 
            260                 265                 270         


Val Asp Arg Asn Ser Cys Lys Leu Ser Ser Ser Phe Ile Ile Thr Gln 
        275                 280                 285             


Asn Met Phe Cys Ala Gly Tyr Asp Thr Lys Gln Glu Asp Ala Cys Gln 
    290                 295                 300                 


Gly Asp Ser Gly Gly Pro His Val Thr Arg Phe Lys Asp Thr Tyr Phe 
305                 310                 315                 320 


Val Thr Gly Ile Val Ser Trp Gly Glu Gly Cys Ala Arg Lys Gly Lys 
                325                 330                 335     


Tyr Gly Ile Tyr Thr Lys Val Thr Ala Phe Leu Lys Trp Ile Asp Arg 
            340                 345                 350         


Ser Met Lys Thr Arg Gly Leu Pro Lys Ala Lys Ser His Ala Pro Glu 
        355                 360                 365             


Val Ile Thr Ser Ser Pro Leu Lys 
    370                 375     


<210>  64
<211>  377
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  SEQ ID NO:27 avec peptide signal MB7

<400>  64

Met Arg Trp Ser Trp Ile Phe Leu Leu Leu Leu Ser Ile Thr Ser Ala 
1               5                   10                  15      


Asn Ala Asn Lys Tyr Lys Asp Gly Asp Gln Cys Glu Thr Ser Pro Cys 
            20                  25                  30          


Gln Asn Gln Gly Lys Cys Lys Asp Gly Leu Gly Glu Tyr Thr Cys Thr 
        35                  40                  45              


Cys Leu Glu Gly Phe Glu Gly Lys Asn Cys Glu Leu Phe Thr Arg Lys 
    50                  55                  60                  


Leu Cys Ser Leu Asp Asn Gly Asp Cys Asp Gln Phe Cys His Glu Glu 
65                  70                  75                  80  


Gln Asn Ser Val Val Cys Ser Cys Ala Arg Gly Tyr Thr Leu Ala Asp 
                85                  90                  95      


Asn Gly Lys Ala Cys Ile Pro Thr Gly Pro Tyr Pro Cys Gly Lys Gln 
            100                 105                 110         


Thr Leu Glu Gly Ser Ser Gly Arg Arg Lys Arg Ile Val Gly Gly Gln 
        115                 120                 125             


Glu Cys Lys Asp Gly Glu Cys Pro Trp Gln Ala Leu Leu Ile Asn Glu 
    130                 135                 140                 


Glu Asn Glu Gly Phe Cys Gly Gly Thr Ile Leu Ser Glu Phe Tyr Ile 
145                 150                 155                 160 


Leu Thr Ala Ala His Cys Leu Tyr Gln Ala Lys Arg Phe Lys Val Arg 
                165                 170                 175     


Val Gly Asp Arg Asn Thr Glu Gln Glu Glu Gly Gly Glu Ala Val His 
            180                 185                 190         


Glu Val Glu Val Val Ile Lys His Asn Arg Phe Thr Lys Glu Thr Tyr 
        195                 200                 205             


Asp Phe Asp Ile Ala Val Leu Arg Leu Lys Thr Pro Ile Thr Phe Arg 
    210                 215                 220                 


Met Asn Val Ala Pro Ala Cys Leu Pro Glu Arg Asp Trp Ala Glu Ser 
225                 230                 235                 240 


Thr Leu Met Thr Gln Lys Thr Gly Ile Val Ser Gly Phe Gly Arg Thr 
                245                 250                 255     


His Glu Lys Gly Arg Gln Ser Thr Arg Leu Lys Met Leu Glu Val Pro 
            260                 265                 270         


Tyr Val Asp Arg Asn Ser Cys Lys Leu Ser Ser Ser Phe Ile Ile Thr 
        275                 280                 285             


Gln Asn Met Phe Cys Ala Gly Tyr Asp Thr Lys Gln Glu Asp Ala Cys 
    290                 295                 300                 


Gln Gly Asp Ser Gly Gly Pro His Val Thr Arg Phe Lys Asp Thr Tyr 
305                 310                 315                 320 


Phe Val Thr Gly Ile Val Ser Trp Gly Glu Gly Cys Ala Arg Lys Gly 
                325                 330                 335     


Lys Tyr Gly Ile Tyr Thr Lys Val Thr Ala Phe Leu Lys Trp Ile Asp 
            340                 345                 350         


Arg Ser Met Lys Thr Arg Gly Leu Pro Lys Ala Lys Ser His Ala Pro 
        355                 360                 365             


Glu Val Ile Thr Ser Ser Pro Leu Lys 
    370                 375         


<210>  65
<211>  378
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  GPAD3-LC avec peptide signal MB7

<400>  65

Met Arg Trp Ser Trp Ile Phe Leu Leu Leu Leu Ser Ile Thr Ser Ala 
1               5                   10                  15      


Asn Ala Asn Lys Tyr Lys Asp Gly Asp Gln Cys Glu Thr Ser Pro Cys 
            20                  25                  30          


Gln Asn Gln Gly Lys Cys Lys Asp Gly Leu Gly Glu Tyr Thr Cys Thr 
        35                  40                  45              


Cys Leu Glu Gly Phe Glu Gly Lys Asn Cys Glu Leu Phe Thr Arg Lys 
    50                  55                  60                  


Leu Cys Ser Leu Asp Asn Gly Asp Cys Asp Gln Phe Cys His Glu Glu 
65                  70                  75                  80  


Gln Asn Ser Val Val Cys Ser Cys Ala Arg Gly Tyr Thr Leu Ala Asp 
                85                  90                  95      


Asn Gly Lys Ala Cys Ile Pro Thr Gly Pro Tyr Pro Cys Gly Lys Gln 
            100                 105                 110         


Thr Leu Glu Arg Gly Ser Ser Gly Arg Arg Lys Arg Ile Val Gly Gly 
        115                 120                 125             


Gln Glu Cys Lys Asp Gly Glu Cys Pro Trp Gln Ala Leu Leu Ile Asn 
    130                 135                 140                 


Glu Glu Asn Glu Gly Phe Cys Gly Gly Thr Ile Leu Ser Glu Phe Tyr 
145                 150                 155                 160 


Ile Leu Thr Ala Ala His Cys Leu Tyr Gln Ala Lys Arg Phe Lys Val 
                165                 170                 175     


Arg Val Gly Asp Arg Asn Thr Glu Gln Glu Glu Gly Gly Glu Ala Val 
            180                 185                 190         


His Glu Val Glu Val Val Ile Lys His Asn Arg Phe Thr Lys Glu Thr 
        195                 200                 205             


Tyr Asp Phe Asp Ile Ala Val Leu Arg Leu Lys Thr Pro Ile Thr Phe 
    210                 215                 220                 


Arg Met Asn Val Ala Pro Ala Cys Leu Pro Glu Arg Asp Trp Ala Glu 
225                 230                 235                 240 


Ser Thr Leu Met Thr Gln Lys Thr Gly Ile Val Ser Gly Phe Gly Arg 
                245                 250                 255     


Thr His Glu Lys Gly Arg Gln Ser Thr Arg Leu Lys Met Leu Glu Val 
            260                 265                 270         


Pro Tyr Val Asp Arg Asn Ser Cys Lys Leu Ser Ser Ser Phe Ile Ile 
        275                 280                 285             


Thr Gln Asn Met Phe Cys Ala Gly Tyr Asp Thr Lys Gln Glu Asp Ala 
    290                 295                 300                 


Cys Gln Gly Asp Ser Gly Gly Pro His Val Thr Arg Phe Lys Asp Thr 
305                 310                 315                 320 


Tyr Phe Val Thr Gly Ile Val Ser Trp Gly Glu Gly Cys Ala Arg Lys 
                325                 330                 335     


Gly Lys Tyr Gly Ile Tyr Thr Lys Val Thr Ala Phe Leu Lys Trp Ile 
            340                 345                 350         


Asp Arg Ser Met Lys Thr Arg Gly Leu Pro Lys Ala Lys Ser His Ala 
        355                 360                 365             


Pro Glu Val Ile Thr Ser Ser Pro Leu Lys 
    370                 375             


<210>  66
<211>  384
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  GPAD3-LL avec peptide signal MB7

<400>  66

Met Arg Trp Ser Trp Ile Phe Leu Leu Leu Leu Ser Ile Thr Ser Ala 
1               5                   10                  15      


Asn Ala Asn Lys Tyr Lys Asp Gly Asp Gln Cys Glu Thr Ser Pro Cys 
            20                  25                  30          


Gln Asn Gln Gly Lys Cys Lys Asp Gly Leu Gly Glu Tyr Thr Cys Thr 
        35                  40                  45              


Cys Leu Glu Gly Phe Glu Gly Lys Asn Cys Glu Leu Phe Thr Arg Lys 
    50                  55                  60                  


Leu Cys Ser Leu Asp Asn Gly Asp Cys Asp Gln Phe Cys His Glu Glu 
65                  70                  75                  80  


Gln Asn Ser Val Val Cys Ser Cys Ala Arg Gly Tyr Thr Leu Ala Asp 
                85                  90                  95      


Asn Gly Lys Ala Cys Ile Pro Thr Gly Pro Tyr Pro Cys Gly Lys Gln 
            100                 105                 110         


Thr Leu Glu Arg Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Arg Arg 
        115                 120                 125             


Lys Arg Ile Val Gly Gly Gln Glu Cys Lys Asp Gly Glu Cys Pro Trp 
    130                 135                 140                 


Gln Ala Leu Leu Ile Asn Glu Glu Asn Glu Gly Phe Cys Gly Gly Thr 
145                 150                 155                 160 


Ile Leu Ser Glu Phe Tyr Ile Leu Thr Ala Ala His Cys Leu Tyr Gln 
                165                 170                 175     


Ala Lys Arg Phe Lys Val Arg Val Gly Asp Arg Asn Thr Glu Gln Glu 
            180                 185                 190         


Glu Gly Gly Glu Ala Val His Glu Val Glu Val Val Ile Lys His Asn 
        195                 200                 205             


Arg Phe Thr Lys Glu Thr Tyr Asp Phe Asp Ile Ala Val Leu Arg Leu 
    210                 215                 220                 


Lys Thr Pro Ile Thr Phe Arg Met Asn Val Ala Pro Ala Cys Leu Pro 
225                 230                 235                 240 


Glu Arg Asp Trp Ala Glu Ser Thr Leu Met Thr Gln Lys Thr Gly Ile 
                245                 250                 255     


Val Ser Gly Phe Gly Arg Thr His Glu Lys Gly Arg Gln Ser Thr Arg 
            260                 265                 270         


Leu Lys Met Leu Glu Val Pro Tyr Val Asp Arg Asn Ser Cys Lys Leu 
        275                 280                 285             


Ser Ser Ser Phe Ile Ile Thr Gln Asn Met Phe Cys Ala Gly Tyr Asp 
    290                 295                 300                 


Thr Lys Gln Glu Asp Ala Cys Gln Gly Asp Ser Gly Gly Pro His Val 
305                 310                 315                 320 


Thr Arg Phe Lys Asp Thr Tyr Phe Val Thr Gly Ile Val Ser Trp Gly 
                325                 330                 335     


Glu Gly Cys Ala Arg Lys Gly Lys Tyr Gly Ile Tyr Thr Lys Val Thr 
            340                 345                 350         


Ala Phe Leu Lys Trp Ile Asp Arg Ser Met Lys Thr Arg Gly Leu Pro 
        355                 360                 365             


Lys Ala Lys Ser His Ala Pro Glu Val Ile Thr Ser Ser Pro Leu Lys 
    370                 375                 380                 


<210>  67
<211>  387
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  GPAD3-2F avec peptide signal MB7

<400>  67

Met Arg Trp Ser Trp Ile Phe Leu Leu Leu Leu Ser Ile Thr Ser Ala 
1               5                   10                  15      


Asn Ala Asn Lys Tyr Lys Asp Gly Asp Gln Cys Glu Thr Ser Pro Cys 
            20                  25                  30          


Gln Asn Gln Gly Lys Cys Lys Asp Gly Leu Gly Glu Tyr Thr Cys Thr 
        35                  40                  45              


Cys Leu Glu Gly Phe Glu Gly Lys Asn Cys Glu Leu Phe Thr Arg Lys 
    50                  55                  60                  


Leu Cys Ser Leu Asp Asn Gly Asp Cys Asp Gln Phe Cys His Glu Glu 
65                  70                  75                  80  


Gln Asn Ser Val Val Cys Ser Cys Ala Arg Gly Tyr Thr Leu Ala Asp 
                85                  90                  95      


Asn Gly Lys Ala Cys Ile Pro Thr Gly Pro Tyr Pro Cys Gly Lys Gln 
            100                 105                 110         


Thr Leu Glu Arg Arg Lys Arg Gly Gly Gly Gly Ser Gly Gly Gly Gly 
        115                 120                 125             


Ser Arg Arg Lys Arg Ile Val Gly Gly Gln Glu Cys Lys Asp Gly Glu 
    130                 135                 140                 


Cys Pro Trp Gln Ala Leu Leu Ile Asn Glu Glu Asn Glu Gly Phe Cys 
145                 150                 155                 160 


Gly Gly Thr Ile Leu Ser Glu Phe Tyr Ile Leu Thr Ala Ala His Cys 
                165                 170                 175     


Leu Tyr Gln Ala Lys Arg Phe Lys Val Arg Val Gly Asp Arg Asn Thr 
            180                 185                 190         


Glu Gln Glu Glu Gly Gly Glu Ala Val His Glu Val Glu Val Val Ile 
        195                 200                 205             


Lys His Asn Arg Phe Thr Lys Glu Thr Tyr Asp Phe Asp Ile Ala Val 
    210                 215                 220                 


Leu Arg Leu Lys Thr Pro Ile Thr Phe Arg Met Asn Val Ala Pro Ala 
225                 230                 235                 240 


Cys Leu Pro Glu Arg Asp Trp Ala Glu Ser Thr Leu Met Thr Gln Lys 
                245                 250                 255     


Thr Gly Ile Val Ser Gly Phe Gly Arg Thr His Glu Lys Gly Arg Gln 
            260                 265                 270         


Ser Thr Arg Leu Lys Met Leu Glu Val Pro Tyr Val Asp Arg Asn Ser 
        275                 280                 285             


Cys Lys Leu Ser Ser Ser Phe Ile Ile Thr Gln Asn Met Phe Cys Ala 
    290                 295                 300                 


Gly Tyr Asp Thr Lys Gln Glu Asp Ala Cys Gln Gly Asp Ser Gly Gly 
305                 310                 315                 320 


Pro His Val Thr Arg Phe Lys Asp Thr Tyr Phe Val Thr Gly Ile Val 
                325                 330                 335     


Ser Trp Gly Glu Gly Cys Ala Arg Lys Gly Lys Tyr Gly Ile Tyr Thr 
            340                 345                 350         


Lys Val Thr Ala Phe Leu Lys Trp Ile Asp Arg Ser Met Lys Thr Arg 
        355                 360                 365             


Gly Leu Pro Lys Ala Lys Ser His Ala Pro Glu Val Ile Thr Ser Ser 
    370                 375                 380                 


Pro Leu Lys 
385         


<210>  68
<211>  604
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  GPAD2-FX-Fc avec peptide signal MB7

<400>  68

Met Arg Trp Ser Trp Ile Phe Leu Leu Leu Leu Ser Ile Thr Ser Ala 
1               5                   10                  15      


Asn Ala Ser Asn Lys Tyr Lys Asp Gly Asp Gln Cys Glu Thr Ser Pro 
            20                  25                  30          


Cys Gln Asn Gln Gly Lys Cys Lys Asp Gly Leu Gly Glu Tyr Thr Cys 
        35                  40                  45              


Thr Cys Leu Glu Gly Phe Glu Gly Lys Asn Cys Glu Leu Phe Thr Arg 
    50                  55                  60                  


Lys Leu Cys Ser Leu Asp Asn Gly Asp Cys Asp Gln Phe Cys His Glu 
65                  70                  75                  80  


Glu Gln Asn Ser Val Val Cys Ser Cys Ala Arg Gly Tyr Thr Leu Ala 
                85                  90                  95      


Asp Asn Gly Lys Ala Cys Ile Pro Thr Gly Pro Tyr Pro Cys Gly Lys 
            100                 105                 110         


Gln Thr Leu Glu Arg Arg Lys Arg Arg Lys Arg Ile Val Gly Gly Gln 
        115                 120                 125             


Glu Cys Lys Asp Gly Glu Cys Pro Trp Gln Ala Leu Leu Ile Asn Glu 
    130                 135                 140                 


Glu Asn Glu Gly Phe Cys Gly Gly Thr Ile Leu Ser Glu Phe Tyr Ile 
145                 150                 155                 160 


Leu Thr Ala Ala His Cys Leu Tyr Gln Ala Lys Arg Phe Lys Val Arg 
                165                 170                 175     


Val Gly Asp Arg Asn Thr Glu Gln Glu Glu Gly Gly Glu Ala Val His 
            180                 185                 190         


Glu Val Glu Val Val Ile Lys His Asn Arg Phe Thr Lys Glu Thr Tyr 
        195                 200                 205             


Asp Phe Asp Ile Ala Val Leu Arg Leu Lys Thr Pro Ile Thr Phe Arg 
    210                 215                 220                 


Met Asn Val Ala Pro Ala Cys Leu Pro Glu Arg Asp Trp Ala Glu Ser 
225                 230                 235                 240 


Thr Leu Met Thr Gln Lys Thr Gly Ile Val Ser Gly Phe Gly Arg Thr 
                245                 250                 255     


His Glu Lys Gly Arg Gln Ser Thr Arg Leu Lys Met Leu Glu Val Pro 
            260                 265                 270         


Tyr Val Asp Arg Asn Ser Cys Lys Leu Ser Ser Ser Phe Ile Ile Thr 
        275                 280                 285             


Gln Asn Met Phe Cys Ala Gly Tyr Asp Thr Lys Gln Glu Asp Ala Cys 
    290                 295                 300                 


Gln Gly Asp Ser Gly Gly Pro His Val Thr Arg Phe Lys Asp Thr Tyr 
305                 310                 315                 320 


Phe Val Thr Gly Ile Val Ser Trp Gly Glu Gly Cys Ala Arg Lys Gly 
                325                 330                 335     


Lys Tyr Gly Ile Tyr Thr Lys Val Thr Ala Phe Leu Lys Trp Ile Asp 
            340                 345                 350         


Arg Ser Met Lys Thr Arg Gly Leu Pro Lys Ala Lys Ser His Ala Pro 
        355                 360                 365             


Glu Val Ile Thr Ser Ser Pro Leu Lys Asp Lys Thr His Thr Cys Pro 
    370                 375                 380                 


Pro Cys Pro Ala Pro Glu Leu Leu Gly Gly Pro Ser Val Phe Leu Phe 
385                 390                 395                 400 


Pro Pro Lys Pro Lys Asp Thr Leu Met Ile Ser Arg Thr Pro Glu Val 
                405                 410                 415     


Thr Cys Val Val Val Asp Val Ser His Glu Asp Pro Glu Val Lys Phe 
            420                 425                 430         


Asn Trp Tyr Val Asp Gly Val Glu Val His Asn Ala Lys Thr Lys Pro 
        435                 440                 445             


Arg Glu Glu Gln Tyr Asn Ser Thr Tyr Arg Val Val Ser Val Leu Thr 
    450                 455                 460                 


Val Leu His Gln Asp Trp Leu Asn Gly Lys Glu Tyr Lys Cys Lys Val 
465                 470                 475                 480 


Ser Asn Lys Ala Leu Pro Ala Pro Ile Glu Lys Thr Ile Ser Lys Ala 
                485                 490                 495     


Lys Gly Gln Pro Arg Glu Pro Gln Val Tyr Thr Leu Pro Pro Ser Arg 
            500                 505                 510         


Asp Glu Leu Thr Lys Asn Gln Val Ser Leu Thr Cys Leu Val Lys Gly 
        515                 520                 525             


Phe Tyr Pro Ser Asp Ile Ala Val Glu Trp Glu Ser Asn Gly Gln Pro 
    530                 535                 540                 


Glu Asn Asn Tyr Lys Thr Thr Pro Pro Val Leu Asp Ser Asp Gly Ser 
545                 550                 555                 560 


Phe Phe Leu Tyr Ser Lys Leu Thr Val Asp Lys Ser Arg Trp Gln Gln 
                565                 570                 575     


Gly Asn Val Phe Ser Cys Ser Val Met His Glu Ala Leu His Asn His 
            580                 585                 590         


Tyr Thr Gln Lys Ser Leu Ser Leu Ser Pro Gly Lys 
        595                 600                 


<210>  69
<211>  609
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  GPAD2-Fcl avec peptide signal MB7

<400>  69

Met Arg Trp Ser Trp Ile Phe Leu Leu Leu Leu Ser Ile Thr Ser Ala 
1               5                   10                  15      


Asn Ala Ser Asn Lys Tyr Lys Asp Gly Asp Gln Cys Glu Thr Ser Pro 
            20                  25                  30          


Cys Gln Asn Gln Gly Lys Cys Lys Asp Gly Leu Gly Glu Tyr Thr Cys 
        35                  40                  45              


Thr Cys Leu Glu Gly Phe Glu Gly Lys Asn Cys Glu Leu Phe Thr Arg 
    50                  55                  60                  


Lys Leu Cys Ser Leu Asp Asn Gly Asp Cys Asp Gln Phe Cys His Glu 
65                  70                  75                  80  


Glu Gln Asn Ser Val Val Cys Ser Cys Ala Arg Gly Tyr Thr Leu Ala 
                85                  90                  95      


Asp Asn Gly Lys Ala Cys Ile Pro Thr Gly Pro Tyr Pro Cys Gly Lys 
            100                 105                 110         


Gln Thr Leu Glu Arg Arg Lys Arg Arg Lys Arg Ile Val Gly Gly Gln 
        115                 120                 125             


Glu Cys Lys Asp Gly Glu Cys Pro Trp Gln Ala Leu Leu Ile Asn Glu 
    130                 135                 140                 


Glu Asn Glu Gly Phe Cys Gly Gly Thr Ile Leu Ser Glu Phe Tyr Ile 
145                 150                 155                 160 


Leu Thr Ala Ala His Cys Leu Tyr Gln Ala Lys Arg Phe Lys Val Arg 
                165                 170                 175     


Val Gly Asp Arg Asn Thr Glu Gln Glu Glu Gly Gly Glu Ala Val His 
            180                 185                 190         


Glu Val Glu Val Val Ile Lys His Asn Arg Phe Thr Lys Glu Thr Tyr 
        195                 200                 205             


Asp Phe Asp Ile Ala Val Leu Arg Leu Lys Thr Pro Ile Thr Phe Arg 
    210                 215                 220                 


Met Asn Val Ala Pro Ala Cys Leu Pro Glu Arg Asp Trp Ala Glu Ser 
225                 230                 235                 240 


Thr Leu Met Thr Gln Lys Thr Gly Ile Val Ser Gly Phe Gly Arg Thr 
                245                 250                 255     


His Glu Lys Gly Arg Gln Ser Thr Arg Leu Lys Met Leu Glu Val Pro 
            260                 265                 270         


Tyr Val Asp Arg Asn Ser Cys Lys Leu Ser Ser Ser Phe Ile Ile Thr 
        275                 280                 285             


Gln Asn Met Phe Cys Ala Gly Tyr Asp Thr Lys Gln Glu Asp Ala Cys 
    290                 295                 300                 


Gln Gly Asp Ser Gly Gly Pro His Val Thr Arg Phe Lys Asp Thr Tyr 
305                 310                 315                 320 


Phe Val Thr Gly Ile Val Ser Trp Gly Glu Gly Cys Ala Arg Lys Gly 
                325                 330                 335     


Lys Tyr Gly Ile Tyr Thr Lys Val Thr Ala Phe Leu Lys Trp Ile Asp 
            340                 345                 350         


Arg Ser Met Lys Thr Arg Gly Leu Pro Lys Ala Lys Ser His Ala Pro 
        355                 360                 365             


Glu Val Ile Thr Ser Ser Pro Leu Lys Glu Pro Lys Ser Cys Asp Lys 
    370                 375                 380                 


Thr His Thr Cys Pro Pro Cys Pro Ala Pro Glu Leu Leu Gly Gly Pro 
385                 390                 395                 400 


Ser Val Phe Leu Phe Pro Pro Lys Pro Lys Asp Thr Leu Met Ile Ser 
                405                 410                 415     


Arg Thr Pro Glu Val Thr Cys Val Val Val Asp Val Ser His Glu Asp 
            420                 425                 430         


Pro Glu Val Lys Phe Asn Trp Tyr Val Asp Gly Val Glu Val His Asn 
        435                 440                 445             


Ala Lys Thr Lys Pro Arg Glu Glu Gln Tyr Asn Ser Thr Tyr Arg Val 
    450                 455                 460                 


Val Ser Val Leu Thr Val Leu His Gln Asp Trp Leu Asn Gly Lys Glu 
465                 470                 475                 480 


Tyr Lys Cys Lys Val Ser Asn Lys Ala Leu Pro Ala Pro Ile Glu Lys 
                485                 490                 495     


Thr Ile Ser Lys Ala Lys Gly Gln Pro Arg Glu Pro Gln Val Tyr Thr 
            500                 505                 510         


Leu Pro Pro Ser Arg Asp Glu Leu Thr Lys Asn Gln Val Ser Leu Thr 
        515                 520                 525             


Cys Leu Val Lys Gly Phe Tyr Pro Ser Asp Ile Ala Val Glu Trp Glu 
    530                 535                 540                 


Ser Asn Gly Gln Pro Glu Asn Asn Tyr Lys Thr Thr Pro Pro Val Leu 
545                 550                 555                 560 


Asp Ser Asp Gly Ser Phe Phe Leu Tyr Ser Lys Leu Thr Val Asp Lys 
                565                 570                 575     


Ser Arg Trp Gln Gln Gly Asn Val Phe Ser Cys Ser Val Met His Glu 
            580                 585                 590         


Ala Leu His Asn His Tyr Thr Gln Lys Ser Leu Ser Leu Ser Pro Gly 
        595                 600                 605             


Lys 
    


<210>  70
<211>  608
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  GPAD2-FcLss avec peptide signal MB7

<400>  70

Met Arg Trp Ser Trp Ile Phe Leu Leu Leu Leu Ser Ile Thr Ser Ala 
1               5                   10                  15      


Asn Ala Asn Lys Tyr Lys Asp Gly Asp Gln Cys Glu Thr Ser Pro Cys 
            20                  25                  30          


Gln Asn Gln Gly Lys Cys Lys Asp Gly Leu Gly Glu Tyr Thr Cys Thr 
        35                  40                  45              


Cys Leu Glu Gly Phe Glu Gly Lys Asn Cys Glu Leu Phe Thr Arg Lys 
    50                  55                  60                  


Leu Cys Ser Leu Asp Asn Gly Asp Cys Asp Gln Phe Cys His Glu Glu 
65                  70                  75                  80  


Gln Asn Ser Val Val Cys Ser Cys Ala Arg Gly Tyr Thr Leu Ala Asp 
                85                  90                  95      


Asn Gly Lys Ala Cys Ile Pro Thr Gly Pro Tyr Pro Cys Gly Lys Gln 
            100                 105                 110         


Thr Leu Glu Arg Arg Lys Arg Arg Lys Arg Ile Val Gly Gly Gln Glu 
        115                 120                 125             


Cys Lys Asp Gly Glu Cys Pro Trp Gln Ala Leu Leu Ile Asn Glu Glu 
    130                 135                 140                 


Asn Glu Gly Phe Cys Gly Gly Thr Ile Leu Ser Glu Phe Tyr Ile Leu 
145                 150                 155                 160 


Thr Ala Ala His Cys Leu Tyr Gln Ala Lys Arg Phe Lys Val Arg Val 
                165                 170                 175     


Gly Asp Arg Asn Thr Glu Gln Glu Glu Gly Gly Glu Ala Val His Glu 
            180                 185                 190         


Val Glu Val Val Ile Lys His Asn Arg Phe Thr Lys Glu Thr Tyr Asp 
        195                 200                 205             


Phe Asp Ile Ala Val Leu Arg Leu Lys Thr Pro Ile Thr Phe Arg Met 
    210                 215                 220                 


Asn Val Ala Pro Ala Cys Leu Pro Glu Arg Asp Trp Ala Glu Ser Thr 
225                 230                 235                 240 


Leu Met Thr Gln Lys Thr Gly Ile Val Ser Gly Phe Gly Arg Thr His 
                245                 250                 255     


Glu Lys Gly Arg Gln Ser Thr Arg Leu Lys Met Leu Glu Val Pro Tyr 
            260                 265                 270         


Val Asp Arg Asn Ser Cys Lys Leu Ser Ser Ser Phe Ile Ile Thr Gln 
        275                 280                 285             


Asn Met Phe Cys Ala Gly Tyr Asp Thr Lys Gln Glu Asp Ala Cys Gln 
    290                 295                 300                 


Gly Asp Ser Gly Gly Pro His Val Thr Arg Phe Lys Asp Thr Tyr Phe 
305                 310                 315                 320 


Val Thr Gly Ile Val Ser Trp Gly Glu Gly Cys Ala Arg Lys Gly Lys 
                325                 330                 335     


Tyr Gly Ile Tyr Thr Lys Val Thr Ala Phe Leu Lys Trp Ile Asp Arg 
            340                 345                 350         


Ser Met Lys Thr Arg Gly Leu Pro Lys Ala Lys Ser His Ala Pro Glu 
        355                 360                 365             


Val Ile Thr Ser Ser Pro Leu Lys Glu Pro Lys Ser Cys Asp Lys Thr 
    370                 375                 380                 


His Thr Cys Pro Pro Cys Pro Ala Pro Glu Leu Leu Gly Gly Pro Ser 
385                 390                 395                 400 


Val Phe Leu Phe Pro Pro Lys Pro Lys Asp Thr Leu Met Ile Ser Arg 
                405                 410                 415     


Thr Pro Glu Val Thr Cys Val Val Val Asp Val Ser His Glu Asp Pro 
            420                 425                 430         


Glu Val Lys Phe Asn Trp Tyr Val Asp Gly Val Glu Val His Asn Ala 
        435                 440                 445             


Lys Thr Lys Pro Arg Glu Glu Gln Tyr Asn Ser Thr Tyr Arg Val Val 
    450                 455                 460                 


Ser Val Leu Thr Val Leu His Gln Asp Trp Leu Asn Gly Lys Glu Tyr 
465                 470                 475                 480 


Lys Cys Lys Val Ser Asn Lys Ala Leu Pro Ala Pro Ile Glu Lys Thr 
                485                 490                 495     


Ile Ser Lys Ala Lys Gly Gln Pro Arg Glu Pro Gln Val Tyr Thr Leu 
            500                 505                 510         


Pro Pro Ser Arg Asp Glu Leu Thr Lys Asn Gln Val Ser Leu Thr Cys 
        515                 520                 525             


Leu Val Lys Gly Phe Tyr Pro Ser Asp Ile Ala Val Glu Trp Glu Ser 
    530                 535                 540                 


Asn Gly Gln Pro Glu Asn Asn Tyr Lys Thr Thr Pro Pro Val Leu Asp 
545                 550                 555                 560 


Ser Asp Gly Ser Phe Phe Leu Tyr Ser Lys Leu Thr Val Asp Lys Ser 
                565                 570                 575     


Arg Trp Gln Gln Gly Asn Val Phe Ser Cys Ser Val Met His Glu Ala 
            580                 585                 590         


Leu His Asn His Tyr Thr Gln Lys Ser Leu Ser Leu Ser Pro Gly Lys 
        595                 600                 605             


<210>  71
<211>  849
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  GPAD2-scFcL avec peptide signal MB7

<400>  71

Met Arg Trp Ser Trp Ile Phe Leu Leu Leu Leu Ser Ile Thr Ser Ala 
1               5                   10                  15      


Asn Ala Ser Asn Lys Tyr Lys Asp Gly Asp Gln Cys Glu Thr Ser Pro 
            20                  25                  30          


Cys Gln Asn Gln Gly Lys Cys Lys Asp Gly Leu Gly Glu Tyr Thr Cys 
        35                  40                  45              


Thr Cys Leu Glu Gly Phe Glu Gly Lys Asn Cys Glu Leu Phe Thr Arg 
    50                  55                  60                  


Lys Leu Cys Ser Leu Asp Asn Gly Asp Cys Asp Gln Phe Cys His Glu 
65                  70                  75                  80  


Glu Gln Asn Ser Val Val Cys Ser Cys Ala Arg Gly Tyr Thr Leu Ala 
                85                  90                  95      


Asp Asn Gly Lys Ala Cys Ile Pro Thr Gly Pro Tyr Pro Cys Gly Lys 
            100                 105                 110         


Gln Thr Leu Glu Arg Arg Lys Arg Arg Lys Arg Ile Val Gly Gly Gln 
        115                 120                 125             


Glu Cys Lys Asp Gly Glu Cys Pro Trp Gln Ala Leu Leu Ile Asn Glu 
    130                 135                 140                 


Glu Asn Glu Gly Phe Cys Gly Gly Thr Ile Leu Ser Glu Phe Tyr Ile 
145                 150                 155                 160 


Leu Thr Ala Ala His Cys Leu Tyr Gln Ala Lys Arg Phe Lys Val Arg 
                165                 170                 175     


Val Gly Asp Arg Asn Thr Glu Gln Glu Glu Gly Gly Glu Ala Val His 
            180                 185                 190         


Glu Val Glu Val Val Ile Lys His Asn Arg Phe Thr Lys Glu Thr Tyr 
        195                 200                 205             


Asp Phe Asp Ile Ala Val Leu Arg Leu Lys Thr Pro Ile Thr Phe Arg 
    210                 215                 220                 


Met Asn Val Ala Pro Ala Cys Leu Pro Glu Arg Asp Trp Ala Glu Ser 
225                 230                 235                 240 


Thr Leu Met Thr Gln Lys Thr Gly Ile Val Ser Gly Phe Gly Arg Thr 
                245                 250                 255     


His Glu Lys Gly Arg Gln Ser Thr Arg Leu Lys Met Leu Glu Val Pro 
            260                 265                 270         


Tyr Val Asp Arg Asn Ser Cys Lys Leu Ser Ser Ser Phe Ile Ile Thr 
        275                 280                 285             


Gln Asn Met Phe Cys Ala Gly Tyr Asp Thr Lys Gln Glu Asp Ala Cys 
    290                 295                 300                 


Gln Gly Asp Ser Gly Gly Pro His Val Thr Arg Phe Lys Asp Thr Tyr 
305                 310                 315                 320 


Phe Val Thr Gly Ile Val Ser Trp Gly Glu Gly Cys Ala Arg Lys Gly 
                325                 330                 335     


Lys Tyr Gly Ile Tyr Thr Lys Val Thr Ala Phe Leu Lys Trp Ile Asp 
            340                 345                 350         


Arg Ser Met Lys Thr Arg Gly Leu Pro Lys Ala Lys Ser His Ala Pro 
        355                 360                 365             


Glu Val Ile Thr Ser Ser Pro Leu Lys Asp Lys Thr His Thr Cys Pro 
    370                 375                 380                 


Pro Cys Pro Ala Pro Glu Leu Leu Gly Gly Pro Ser Val Phe Leu Phe 
385                 390                 395                 400 


Pro Pro Lys Pro Lys Asp Thr Leu Met Ile Ser Arg Thr Pro Glu Val 
                405                 410                 415     


Thr Cys Val Val Val Asp Val Ser His Glu Asp Pro Glu Val Lys Phe 
            420                 425                 430         


Asn Trp Tyr Val Asp Gly Val Glu Val His Asn Ala Lys Thr Lys Pro 
        435                 440                 445             


Arg Glu Glu Gln Tyr Asn Ser Thr Tyr Arg Val Val Ser Val Leu Thr 
    450                 455                 460                 


Val Leu His Gln Asp Trp Leu Asn Gly Lys Glu Tyr Lys Cys Lys Val 
465                 470                 475                 480 


Ser Asn Lys Ala Leu Pro Ala Pro Ile Glu Lys Thr Ile Ser Lys Ala 
                485                 490                 495     


Lys Gly Gln Pro Arg Glu Pro Gln Val Tyr Thr Leu Pro Pro Ser Arg 
            500                 505                 510         


Asp Glu Leu Thr Lys Asn Gln Val Ser Leu Thr Cys Leu Val Lys Gly 
        515                 520                 525             


Phe Tyr Pro Ser Asp Ile Ala Val Glu Trp Glu Ser Asn Gly Gln Pro 
    530                 535                 540                 


Glu Asn Asn Tyr Lys Thr Thr Pro Pro Val Leu Asp Ser Asp Gly Ser 
545                 550                 555                 560 


Phe Phe Leu Tyr Ser Lys Leu Thr Val Asp Lys Ser Arg Trp Gln Gln 
                565                 570                 575     


Gly Asn Val Phe Ser Cys Ser Val Met His Glu Ala Leu His Asn His 
            580                 585                 590         


Tyr Thr Gln Lys Ser Leu Ser Leu Ser Pro Gly Gly Gly Gly Gly Ser 
        595                 600                 605             


Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Glu Pro Lys Ser Ser Asp 
    610                 615                 620                 


Lys Thr His Thr Cys Pro Pro Cys Pro Ala Pro Glu Leu Leu Gly Gly 
625                 630                 635                 640 


Pro Ser Val Phe Leu Phe Pro Pro Lys Pro Lys Asp Thr Leu Met Ile 
                645                 650                 655     


Ser Arg Thr Pro Glu Val Thr Cys Val Val Val Asp Val Ser His Glu 
            660                 665                 670         


Asp Pro Glu Val Lys Phe Asn Trp Tyr Val Asp Gly Val Glu Val His 
        675                 680                 685             


Asn Ala Lys Thr Lys Pro Arg Glu Glu Gln Tyr Asn Ser Thr Tyr Arg 
    690                 695                 700                 


Val Val Ser Val Leu Thr Val Leu His Gln Asp Trp Leu Asn Gly Lys 
705                 710                 715                 720 


Glu Tyr Lys Cys Lys Val Ser Asn Lys Ala Leu Pro Ala Pro Ile Glu 
                725                 730                 735     


Lys Thr Ile Ser Lys Ala Lys Gly Gln Pro Arg Glu Pro Gln Val Tyr 
            740                 745                 750         


Thr Leu Pro Pro Ser Arg Asp Glu Leu Thr Lys Asn Gln Val Ser Leu 
        755                 760                 765             


Thr Cys Leu Val Lys Gly Phe Tyr Pro Ser Asp Ile Ala Val Glu Trp 
    770                 775                 780                 


Glu Ser Asn Gly Gln Pro Glu Asn Asn Tyr Lys Thr Thr Pro Pro Val 
785                 790                 795                 800 


Leu Asp Ser Asp Gly Ser Phe Phe Leu Tyr Ser Lys Leu Thr Val Asp 
                805                 810                 815     


Lys Ser Arg Trp Gln Gln Gly Asn Val Phe Ser Cys Ser Val Met His 
            820                 825                 830         


Glu Ala Leu His Asn His Tyr Thr Gln Lys Ser Leu Ser Leu Ser Pro 
        835                 840                 845             


Gly 
    


<210>  72
<211>  839
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  GPAD2-scFcS avec peptide signal MB7

<400>  72

Met Arg Trp Ser Trp Ile Phe Leu Leu Leu Leu Ser Ile Thr Ser Ala 
1               5                   10                  15      


Asn Ala Ser Asn Lys Tyr Lys Asp Gly Asp Gln Cys Glu Thr Ser Pro 
            20                  25                  30          


Cys Gln Asn Gln Gly Lys Cys Lys Asp Gly Leu Gly Glu Tyr Thr Cys 
        35                  40                  45              


Thr Cys Leu Glu Gly Phe Glu Gly Lys Asn Cys Glu Leu Phe Thr Arg 
    50                  55                  60                  


Lys Leu Cys Ser Leu Asp Asn Gly Asp Cys Asp Gln Phe Cys His Glu 
65                  70                  75                  80  


Glu Gln Asn Ser Val Val Cys Ser Cys Ala Arg Gly Tyr Thr Leu Ala 
                85                  90                  95      


Asp Asn Gly Lys Ala Cys Ile Pro Thr Gly Pro Tyr Pro Cys Gly Lys 
            100                 105                 110         


Gln Thr Leu Glu Arg Arg Lys Arg Arg Lys Arg Ile Val Gly Gly Gln 
        115                 120                 125             


Glu Cys Lys Asp Gly Glu Cys Pro Trp Gln Ala Leu Leu Ile Asn Glu 
    130                 135                 140                 


Glu Asn Glu Gly Phe Cys Gly Gly Thr Ile Leu Ser Glu Phe Tyr Ile 
145                 150                 155                 160 


Leu Thr Ala Ala His Cys Leu Tyr Gln Ala Lys Arg Phe Lys Val Arg 
                165                 170                 175     


Val Gly Asp Arg Asn Thr Glu Gln Glu Glu Gly Gly Glu Ala Val His 
            180                 185                 190         


Glu Val Glu Val Val Ile Lys His Asn Arg Phe Thr Lys Glu Thr Tyr 
        195                 200                 205             


Asp Phe Asp Ile Ala Val Leu Arg Leu Lys Thr Pro Ile Thr Phe Arg 
    210                 215                 220                 


Met Asn Val Ala Pro Ala Cys Leu Pro Glu Arg Asp Trp Ala Glu Ser 
225                 230                 235                 240 


Thr Leu Met Thr Gln Lys Thr Gly Ile Val Ser Gly Phe Gly Arg Thr 
                245                 250                 255     


His Glu Lys Gly Arg Gln Ser Thr Arg Leu Lys Met Leu Glu Val Pro 
            260                 265                 270         


Tyr Val Asp Arg Asn Ser Cys Lys Leu Ser Ser Ser Phe Ile Ile Thr 
        275                 280                 285             


Gln Asn Met Phe Cys Ala Gly Tyr Asp Thr Lys Gln Glu Asp Ala Cys 
    290                 295                 300                 


Gln Gly Asp Ser Gly Gly Pro His Val Thr Arg Phe Lys Asp Thr Tyr 
305                 310                 315                 320 


Phe Val Thr Gly Ile Val Ser Trp Gly Glu Gly Cys Ala Arg Lys Gly 
                325                 330                 335     


Lys Tyr Gly Ile Tyr Thr Lys Val Thr Ala Phe Leu Lys Trp Ile Asp 
            340                 345                 350         


Arg Ser Met Lys Thr Arg Gly Leu Pro Lys Ala Lys Ser His Ala Pro 
        355                 360                 365             


Glu Val Ile Thr Ser Ser Pro Leu Lys Asp Lys Thr His Thr Cys Pro 
    370                 375                 380                 


Pro Cys Pro Ala Pro Glu Leu Leu Gly Gly Pro Ser Val Phe Leu Phe 
385                 390                 395                 400 


Pro Pro Lys Pro Lys Asp Thr Leu Met Ile Ser Arg Thr Pro Glu Val 
                405                 410                 415     


Thr Cys Val Val Val Asp Val Ser His Glu Asp Pro Glu Val Lys Phe 
            420                 425                 430         


Asn Trp Tyr Val Asp Gly Val Glu Val His Asn Ala Lys Thr Lys Pro 
        435                 440                 445             


Arg Glu Glu Gln Tyr Asn Ser Thr Tyr Arg Val Val Ser Val Leu Thr 
    450                 455                 460                 


Val Leu His Gln Asp Trp Leu Asn Gly Lys Glu Tyr Lys Cys Lys Val 
465                 470                 475                 480 


Ser Asn Lys Ala Leu Pro Ala Pro Ile Glu Lys Thr Ile Ser Lys Ala 
                485                 490                 495     


Lys Gly Gln Pro Arg Glu Pro Gln Val Tyr Thr Leu Pro Pro Ser Arg 
            500                 505                 510         


Asp Glu Leu Thr Lys Asn Gln Val Ser Leu Thr Cys Leu Val Lys Gly 
        515                 520                 525             


Phe Tyr Pro Ser Asp Ile Ala Val Glu Trp Glu Ser Asn Gly Gln Pro 
    530                 535                 540                 


Glu Asn Asn Tyr Lys Thr Thr Pro Pro Val Leu Asp Ser Asp Gly Ser 
545                 550                 555                 560 


Phe Phe Leu Tyr Ser Lys Leu Thr Val Asp Lys Ser Arg Trp Gln Gln 
                565                 570                 575     


Gly Asn Val Phe Ser Cys Ser Val Met His Glu Ala Leu His Asn His 
            580                 585                 590         


Tyr Thr Gln Lys Ser Leu Ser Leu Ser Pro Gly Gly Gly Gly Gly Ser 
        595                 600                 605             


Glu Pro Lys Ser Ser Asp Lys Thr His Thr Cys Pro Pro Cys Pro Ala 
    610                 615                 620                 


Pro Glu Leu Leu Gly Gly Pro Ser Val Phe Leu Phe Pro Pro Lys Pro 
625                 630                 635                 640 


Lys Asp Thr Leu Met Ile Ser Arg Thr Pro Glu Val Thr Cys Val Val 
                645                 650                 655     


Val Asp Val Ser His Glu Asp Pro Glu Val Lys Phe Asn Trp Tyr Val 
            660                 665                 670         


Asp Gly Val Glu Val His Asn Ala Lys Thr Lys Pro Arg Glu Glu Gln 
        675                 680                 685             


Tyr Asn Ser Thr Tyr Arg Val Val Ser Val Leu Thr Val Leu His Gln 
    690                 695                 700                 


Asp Trp Leu Asn Gly Lys Glu Tyr Lys Cys Lys Val Ser Asn Lys Ala 
705                 710                 715                 720 


Leu Pro Ala Pro Ile Glu Lys Thr Ile Ser Lys Ala Lys Gly Gln Pro 
                725                 730                 735     


Arg Glu Pro Gln Val Tyr Thr Leu Pro Pro Ser Arg Asp Glu Leu Thr 
            740                 745                 750         


Lys Asn Gln Val Ser Leu Thr Cys Leu Val Lys Gly Phe Tyr Pro Ser 
        755                 760                 765             


Asp Ile Ala Val Glu Trp Glu Ser Asn Gly Gln Pro Glu Asn Asn Tyr 
    770                 775                 780                 


Lys Thr Thr Pro Pro Val Leu Asp Ser Asp Gly Ser Phe Phe Leu Tyr 
785                 790                 795                 800 


Ser Lys Leu Thr Val Asp Lys Ser Arg Trp Gln Gln Gly Asn Val Phe 
                805                 810                 815     


Ser Cys Ser Val Met His Glu Ala Leu His Asn His Tyr Thr Gln Lys 
            820                 825                 830         


Ser Leu Ser Leu Ser Pro Gly 
        835                 


<210>  73
<211>  853
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  scFcL-GPAD2 avec peptide signal MB7

<400>  73

Met Arg Trp Ser Trp Ile Phe Leu Leu Leu Leu Ser Ile Thr Ser Ala 
1               5                   10                  15      


Asn Ala Asp Lys Thr His Thr Cys Pro Pro Cys Pro Ala Pro Glu Leu 
            20                  25                  30          


Leu Gly Gly Pro Ser Val Phe Leu Phe Pro Pro Lys Pro Lys Asp Thr 
        35                  40                  45              


Leu Met Ile Ser Arg Thr Pro Glu Val Thr Cys Val Val Val Asp Val 
    50                  55                  60                  


Ser His Glu Asp Pro Glu Val Lys Phe Asn Trp Tyr Val Asp Gly Val 
65                  70                  75                  80  


Glu Val His Asn Ala Lys Thr Lys Pro Arg Glu Glu Gln Tyr Asn Ser 
                85                  90                  95      


Thr Tyr Arg Val Val Ser Val Leu Thr Val Leu His Gln Asp Trp Leu 
            100                 105                 110         


Asn Gly Lys Glu Tyr Lys Cys Lys Val Ser Asn Lys Ala Leu Pro Ala 
        115                 120                 125             


Pro Ile Glu Lys Thr Ile Ser Lys Ala Lys Gly Gln Pro Arg Glu Pro 
    130                 135                 140                 


Gln Val Tyr Thr Leu Pro Pro Ser Arg Asp Glu Leu Thr Lys Asn Gln 
145                 150                 155                 160 


Val Ser Leu Thr Cys Leu Val Lys Gly Phe Tyr Pro Ser Asp Ile Ala 
                165                 170                 175     


Val Glu Trp Glu Ser Asn Gly Gln Pro Glu Asn Asn Tyr Lys Thr Thr 
            180                 185                 190         


Pro Pro Val Leu Asp Ser Asp Gly Ser Phe Phe Leu Tyr Ser Lys Leu 
        195                 200                 205             


Thr Val Asp Lys Ser Arg Trp Gln Gln Gly Asn Val Phe Ser Cys Ser 
    210                 215                 220                 


Val Met His Glu Ala Leu His Asn His Tyr Thr Gln Lys Ser Leu Ser 
225                 230                 235                 240 


Leu Ser Pro Gly Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Gly Gly 
                245                 250                 255     


Gly Gly Ser Glu Pro Lys Ser Ser Asp Lys Thr His Thr Cys Pro Pro 
            260                 265                 270         


Cys Pro Ala Pro Glu Leu Leu Gly Gly Pro Ser Val Phe Leu Phe Pro 
        275                 280                 285             


Pro Lys Pro Lys Asp Thr Leu Met Ile Ser Arg Thr Pro Glu Val Thr 
    290                 295                 300                 


Cys Val Val Val Asp Val Ser His Glu Asp Pro Glu Val Lys Phe Asn 
305                 310                 315                 320 


Trp Tyr Val Asp Gly Val Glu Val His Asn Ala Lys Thr Lys Pro Arg 
                325                 330                 335     


Glu Glu Gln Tyr Asn Ser Thr Tyr Arg Val Val Ser Val Leu Thr Val 
            340                 345                 350         


Leu His Gln Asp Trp Leu Asn Gly Lys Glu Tyr Lys Cys Lys Val Ser 
        355                 360                 365             


Asn Lys Ala Leu Pro Ala Pro Ile Glu Lys Thr Ile Ser Lys Ala Lys 
    370                 375                 380                 


Gly Gln Pro Arg Glu Pro Gln Val Tyr Thr Leu Pro Pro Ser Arg Asp 
385                 390                 395                 400 


Glu Leu Thr Lys Asn Gln Val Ser Leu Thr Cys Leu Val Lys Gly Phe 
                405                 410                 415     


Tyr Pro Ser Asp Ile Ala Val Glu Trp Glu Ser Asn Gly Gln Pro Glu 
            420                 425                 430         


Asn Asn Tyr Lys Thr Thr Pro Pro Val Leu Asp Ser Asp Gly Ser Phe 
        435                 440                 445             


Phe Leu Tyr Ser Lys Leu Thr Val Asp Lys Ser Arg Trp Gln Gln Gly 
    450                 455                 460                 


Asn Val Phe Ser Cys Ser Val Met His Glu Ala Leu His Asn His Tyr 
465                 470                 475                 480 


Thr Gln Lys Ser Leu Ser Leu Ser Pro Gly Gly Gly Gly Gly Ser Asn 
                485                 490                 495     


Lys Tyr Lys Asp Gly Asp Gln Cys Glu Thr Ser Pro Cys Gln Asn Gln 
            500                 505                 510         


Gly Lys Cys Lys Asp Gly Leu Gly Glu Tyr Thr Cys Thr Cys Leu Glu 
        515                 520                 525             


Gly Phe Glu Gly Lys Asn Cys Glu Leu Phe Thr Arg Lys Leu Cys Ser 
    530                 535                 540                 


Leu Asp Asn Gly Asp Cys Asp Gln Phe Cys His Glu Glu Gln Asn Ser 
545                 550                 555                 560 


Val Val Cys Ser Cys Ala Arg Gly Tyr Thr Leu Ala Asp Asn Gly Lys 
                565                 570                 575     


Ala Cys Ile Pro Thr Gly Pro Tyr Pro Cys Gly Lys Gln Thr Leu Glu 
            580                 585                 590         


Arg Arg Lys Arg Arg Lys Arg Ile Val Gly Gly Gln Glu Cys Lys Asp 
        595                 600                 605             


Gly Glu Cys Pro Trp Gln Ala Leu Leu Ile Asn Glu Glu Asn Glu Gly 
    610                 615                 620                 


Phe Cys Gly Gly Thr Ile Leu Ser Glu Phe Tyr Ile Leu Thr Ala Ala 
625                 630                 635                 640 


His Cys Leu Tyr Gln Ala Lys Arg Phe Lys Val Arg Val Gly Asp Arg 
                645                 650                 655     


Asn Thr Glu Gln Glu Glu Gly Gly Glu Ala Val His Glu Val Glu Val 
            660                 665                 670         


Val Ile Lys His Asn Arg Phe Thr Lys Glu Thr Tyr Asp Phe Asp Ile 
        675                 680                 685             


Ala Val Leu Arg Leu Lys Thr Pro Ile Thr Phe Arg Met Asn Val Ala 
    690                 695                 700                 


Pro Ala Cys Leu Pro Glu Arg Asp Trp Ala Glu Ser Thr Leu Met Thr 
705                 710                 715                 720 


Gln Lys Thr Gly Ile Val Ser Gly Phe Gly Arg Thr His Glu Lys Gly 
                725                 730                 735     


Arg Gln Ser Thr Arg Leu Lys Met Leu Glu Val Pro Tyr Val Asp Arg 
            740                 745                 750         


Asn Ser Cys Lys Leu Ser Ser Ser Phe Ile Ile Thr Gln Asn Met Phe 
        755                 760                 765             


Cys Ala Gly Tyr Asp Thr Lys Gln Glu Asp Ala Cys Gln Gly Asp Ser 
    770                 775                 780                 


Gly Gly Pro His Val Thr Arg Phe Lys Asp Thr Tyr Phe Val Thr Gly 
785                 790                 795                 800 


Ile Val Ser Trp Gly Glu Gly Cys Ala Arg Lys Gly Lys Tyr Gly Ile 
                805                 810                 815     


Tyr Thr Lys Val Thr Ala Phe Leu Lys Trp Ile Asp Arg Ser Met Lys 
            820                 825                 830         


Thr Arg Gly Leu Pro Lys Ala Lys Ser His Ala Pro Glu Val Ile Thr 
        835                 840                 845             


Ser Ser Pro Leu Lys 
    850             


<210>  74
<211>  850
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  scFcL-GPAD1 avec peptide signal MB7

<400>  74

Met Arg Trp Ser Trp Ile Phe Leu Leu Leu Leu Ser Ile Thr Ser Ala 
1               5                   10                  15      


Asn Ala Asp Lys Thr His Thr Cys Pro Pro Cys Pro Ala Pro Glu Leu 
            20                  25                  30          


Leu Gly Gly Pro Ser Val Phe Leu Phe Pro Pro Lys Pro Lys Asp Thr 
        35                  40                  45              


Leu Met Ile Ser Arg Thr Pro Glu Val Thr Cys Val Val Val Asp Val 
    50                  55                  60                  


Ser His Glu Asp Pro Glu Val Lys Phe Asn Trp Tyr Val Asp Gly Val 
65                  70                  75                  80  


Glu Val His Asn Ala Lys Thr Lys Pro Arg Glu Glu Gln Tyr Asn Ser 
                85                  90                  95      


Thr Tyr Arg Val Val Ser Val Leu Thr Val Leu His Gln Asp Trp Leu 
            100                 105                 110         


Asn Gly Lys Glu Tyr Lys Cys Lys Val Ser Asn Lys Ala Leu Pro Ala 
        115                 120                 125             


Pro Ile Glu Lys Thr Ile Ser Lys Ala Lys Gly Gln Pro Arg Glu Pro 
    130                 135                 140                 


Gln Val Tyr Thr Leu Pro Pro Ser Arg Asp Glu Leu Thr Lys Asn Gln 
145                 150                 155                 160 


Val Ser Leu Thr Cys Leu Val Lys Gly Phe Tyr Pro Ser Asp Ile Ala 
                165                 170                 175     


Val Glu Trp Glu Ser Asn Gly Gln Pro Glu Asn Asn Tyr Lys Thr Thr 
            180                 185                 190         


Pro Pro Val Leu Asp Ser Asp Gly Ser Phe Phe Leu Tyr Ser Lys Leu 
        195                 200                 205             


Thr Val Asp Lys Ser Arg Trp Gln Gln Gly Asn Val Phe Ser Cys Ser 
    210                 215                 220                 


Val Met His Glu Ala Leu His Asn His Tyr Thr Gln Lys Ser Leu Ser 
225                 230                 235                 240 


Leu Ser Pro Gly Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Gly Gly 
                245                 250                 255     


Gly Gly Ser Glu Pro Lys Ser Ser Asp Lys Thr His Thr Cys Pro Pro 
            260                 265                 270         


Cys Pro Ala Pro Glu Leu Leu Gly Gly Pro Ser Val Phe Leu Phe Pro 
        275                 280                 285             


Pro Lys Pro Lys Asp Thr Leu Met Ile Ser Arg Thr Pro Glu Val Thr 
    290                 295                 300                 


Cys Val Val Val Asp Val Ser His Glu Asp Pro Glu Val Lys Phe Asn 
305                 310                 315                 320 


Trp Tyr Val Asp Gly Val Glu Val His Asn Ala Lys Thr Lys Pro Arg 
                325                 330                 335     


Glu Glu Gln Tyr Asn Ser Thr Tyr Arg Val Val Ser Val Leu Thr Val 
            340                 345                 350         


Leu His Gln Asp Trp Leu Asn Gly Lys Glu Tyr Lys Cys Lys Val Ser 
        355                 360                 365             


Asn Lys Ala Leu Pro Ala Pro Ile Glu Lys Thr Ile Ser Lys Ala Lys 
    370                 375                 380                 


Gly Gln Pro Arg Glu Pro Gln Val Tyr Thr Leu Pro Pro Ser Arg Asp 
385                 390                 395                 400 


Glu Leu Thr Lys Asn Gln Val Ser Leu Thr Cys Leu Val Lys Gly Phe 
                405                 410                 415     


Tyr Pro Ser Asp Ile Ala Val Glu Trp Glu Ser Asn Gly Gln Pro Glu 
            420                 425                 430         


Asn Asn Tyr Lys Thr Thr Pro Pro Val Leu Asp Ser Asp Gly Ser Phe 
        435                 440                 445             


Phe Leu Tyr Ser Lys Leu Thr Val Asp Lys Ser Arg Trp Gln Gln Gly 
    450                 455                 460                 


Asn Val Phe Ser Cys Ser Val Met His Glu Ala Leu His Asn His Tyr 
465                 470                 475                 480 


Thr Gln Lys Ser Leu Ser Leu Ser Pro Gly Gly Gly Gly Gly Ser Asn 
                485                 490                 495     


Lys Tyr Lys Asp Gly Asp Gln Cys Glu Thr Ser Pro Cys Gln Asn Gln 
            500                 505                 510         


Gly Lys Cys Lys Asp Gly Leu Gly Glu Tyr Thr Cys Thr Cys Leu Glu 
        515                 520                 525             


Gly Phe Glu Gly Lys Asn Cys Glu Leu Phe Thr Arg Lys Leu Cys Ser 
    530                 535                 540                 


Leu Asp Asn Gly Asp Cys Asp Gln Phe Cys His Glu Glu Gln Asn Ser 
545                 550                 555                 560 


Val Val Cys Ser Cys Ala Arg Gly Tyr Thr Leu Ala Asp Asn Gly Lys 
                565                 570                 575     


Ala Cys Ile Pro Thr Gly Pro Tyr Pro Cys Gly Lys Gln Thr Leu Glu 
            580                 585                 590         


Arg Arg Lys Arg Ile Val Gly Gly Gln Glu Cys Lys Asp Gly Glu Cys 
        595                 600                 605             


Pro Trp Gln Ala Leu Leu Ile Asn Glu Glu Asn Glu Gly Phe Cys Gly 
    610                 615                 620                 


Gly Thr Ile Leu Ser Glu Phe Tyr Ile Leu Thr Ala Ala His Cys Leu 
625                 630                 635                 640 


Tyr Gln Ala Lys Arg Phe Lys Val Arg Val Gly Asp Arg Asn Thr Glu 
                645                 650                 655     


Gln Glu Glu Gly Gly Glu Ala Val His Glu Val Glu Val Val Ile Lys 
            660                 665                 670         


His Asn Arg Phe Thr Lys Glu Thr Tyr Asp Phe Asp Ile Ala Val Leu 
        675                 680                 685             


Arg Leu Lys Thr Pro Ile Thr Phe Arg Met Asn Val Ala Pro Ala Cys 
    690                 695                 700                 


Leu Pro Glu Arg Asp Trp Ala Glu Ser Thr Leu Met Thr Gln Lys Thr 
705                 710                 715                 720 


Gly Ile Val Ser Gly Phe Gly Arg Thr His Glu Lys Gly Arg Gln Ser 
                725                 730                 735     


Thr Arg Leu Lys Met Leu Glu Val Pro Tyr Val Asp Arg Asn Ser Cys 
            740                 745                 750         


Lys Leu Ser Ser Ser Phe Ile Ile Thr Gln Asn Met Phe Cys Ala Gly 
        755                 760                 765             


Tyr Asp Thr Lys Gln Glu Asp Ala Cys Gln Gly Asp Ser Gly Gly Pro 
    770                 775                 780                 


His Val Thr Arg Phe Lys Asp Thr Tyr Phe Val Thr Gly Ile Val Ser 
785                 790                 795                 800 


Trp Gly Glu Gly Cys Ala Arg Lys Gly Lys Tyr Gly Ile Tyr Thr Lys 
                805                 810                 815     


Val Thr Ala Phe Leu Lys Trp Ile Asp Arg Ser Met Lys Thr Arg Gly 
            820                 825                 830         


Leu Pro Lys Ala Lys Ser His Ala Pro Glu Val Ile Thr Ser Ser Pro 
        835                 840                 845             


Leu Lys 
    850 


<210>  75
<211>  382
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  GPAD 3 de SEQ ID NO:52 avec peptide signal MB7

<400>  75

Met Arg Trp Ser Trp Ile Phe Leu Leu Leu Leu Ser Ile Thr Ser Ala 
1               5                   10                  15      


Asn Ala Asn Lys Tyr Lys Asp Gly Asp Gln Cys Glu Thr Ser Pro Cys 
            20                  25                  30          


Gln Asn Gln Gly Lys Cys Lys Asp Gly Leu Gly Glu Tyr Thr Cys Thr 
        35                  40                  45              


Cys Leu Glu Gly Phe Glu Gly Lys Asn Cys Glu Leu Phe Thr Arg Lys 
    50                  55                  60                  


Leu Cys Ser Leu Asp Asn Gly Asp Cys Asp Gln Phe Cys His Glu Glu 
65                  70                  75                  80  


Gln Asn Ser Val Val Cys Ser Cys Ala Arg Gly Tyr Thr Leu Ala Asp 
                85                  90                  95      


Asn Gly Lys Ala Cys Ile Pro Thr Gly Pro Tyr Pro Cys Gly Lys Gln 
            100                 105                 110         


Thr Leu Glu Arg Gly Gly Gly Gly Ser Arg Arg Lys Arg Arg Lys Arg 
        115                 120                 125             


Ile Val Gly Gly Gln Glu Cys Lys Asp Gly Glu Cys Pro Trp Gln Ala 
    130                 135                 140                 


Leu Leu Ile Asn Glu Glu Asn Glu Gly Phe Cys Gly Gly Thr Ile Leu 
145                 150                 155                 160 


Ser Glu Phe Tyr Ile Leu Thr Ala Ala His Cys Leu Tyr Gln Ala Lys 
                165                 170                 175     


Arg Phe Lys Val Arg Val Gly Asp Arg Asn Thr Glu Gln Glu Glu Gly 
            180                 185                 190         


Gly Glu Ala Val His Glu Val Glu Val Val Ile Lys His Asn Arg Phe 
        195                 200                 205             


Thr Lys Glu Thr Tyr Asp Phe Asp Ile Ala Val Leu Arg Leu Lys Thr 
    210                 215                 220                 


Pro Ile Thr Phe Arg Met Asn Val Ala Pro Ala Cys Leu Pro Glu Arg 
225                 230                 235                 240 


Asp Trp Ala Glu Ser Thr Leu Met Thr Gln Lys Thr Gly Ile Val Ser 
                245                 250                 255     


Gly Phe Gly Arg Thr His Glu Lys Gly Arg Gln Ser Thr Arg Leu Lys 
            260                 265                 270         


Met Leu Glu Val Pro Tyr Val Asp Arg Asn Ser Cys Lys Leu Ser Ser 
        275                 280                 285             


Ser Phe Ile Ile Thr Gln Asn Met Phe Cys Ala Gly Tyr Asp Thr Lys 
    290                 295                 300                 


Gln Glu Asp Ala Cys Gln Gly Asp Ser Gly Gly Pro His Val Thr Arg 
305                 310                 315                 320 


Phe Lys Asp Thr Tyr Phe Val Thr Gly Ile Val Ser Trp Gly Glu Gly 
                325                 330                 335     


Cys Ala Arg Lys Gly Lys Tyr Gly Ile Tyr Thr Lys Val Thr Ala Phe 
            340                 345                 350         


Leu Lys Trp Ile Asp Arg Ser Met Lys Thr Arg Gly Leu Pro Lys Ala 
        355                 360                 365             


Lys Ser His Ala Pro Glu Val Ile Thr Ser Ser Pro Leu Lys 
    370                 375                 380         


<210>  76
<211>  378
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  GPAD3 de SEQ ID NO:53 avec peptide signal MB7

<400>  76

Met Arg Trp Ser Trp Ile Phe Leu Leu Leu Leu Ser Ile Thr Ser Ala 
1               5                   10                  15      


Asn Ala Asn Lys Tyr Lys Asp Gly Asp Gln Cys Glu Thr Ser Pro Cys 
            20                  25                  30          


Gln Asn Gln Gly Lys Cys Lys Asp Gly Leu Gly Glu Tyr Thr Cys Thr 
        35                  40                  45              


Cys Leu Glu Gly Phe Glu Gly Lys Asn Cys Glu Leu Phe Thr Arg Lys 
    50                  55                  60                  


Leu Cys Ser Leu Asp Asn Gly Asp Cys Asp Gln Phe Cys His Glu Glu 
65                  70                  75                  80  


Gln Asn Ser Val Val Cys Ser Cys Ala Arg Gly Tyr Thr Leu Ala Asp 
                85                  90                  95      


Asn Gly Lys Ala Cys Ile Pro Thr Gly Pro Tyr Pro Cys Gly Lys Gln 
            100                 105                 110         


Thr Leu Glu Arg Gly Ser Ser Gly Arg Arg Lys Arg Ile Val Gly Gly 
        115                 120                 125             


Gln Glu Cys Lys Asp Gly Glu Cys Pro Trp Gln Ala Leu Leu Ile Asn 
    130                 135                 140                 


Glu Glu Asn Glu Gly Phe Cys Gly Gly Thr Ile Leu Ser Glu Phe Tyr 
145                 150                 155                 160 


Ile Leu Thr Ala Ala His Cys Leu Tyr Gln Ala Lys Arg Phe Lys Val 
                165                 170                 175     


Arg Val Gly Asp Arg Asn Thr Glu Gln Glu Glu Gly Gly Glu Ala Val 
            180                 185                 190         


His Glu Val Glu Val Val Ile Lys His Asn Arg Phe Thr Lys Glu Thr 
        195                 200                 205             


Tyr Asp Phe Asp Ile Ala Val Leu Arg Leu Lys Thr Pro Ile Thr Phe 
    210                 215                 220                 


Arg Met Asn Val Ala Pro Ala Cys Leu Pro Glu Arg Asp Trp Ala Glu 
225                 230                 235                 240 


Ser Thr Leu Met Thr Gln Lys Thr Gly Ile Val Ser Gly Phe Gly Arg 
                245                 250                 255     


Thr His Glu Lys Gly Arg Gln Ser Thr Arg Leu Lys Met Leu Glu Val 
            260                 265                 270         


Pro Tyr Val Asp Arg Asn Ser Cys Lys Leu Ser Ser Ser Phe Ile Ile 
        275                 280                 285             


Thr Gln Asn Met Phe Cys Ala Gly Tyr Asp Thr Lys Gln Glu Asp Ala 
    290                 295                 300                 


Cys Gln Gly Asp Ser Gly Gly Pro His Val Thr Arg Phe Lys Asp Thr 
305                 310                 315                 320 


Tyr Phe Val Thr Gly Ile Val Ser Trp Gly Glu Gly Cys Ala Arg Lys 
                325                 330                 335     


Gly Lys Tyr Gly Ile Tyr Thr Lys Val Thr Ala Phe Leu Lys Trp Ile 
            340                 345                 350         


Asp Arg Ser Met Lys Thr Arg Gly Leu Pro Lys Ala Lys Ser His Ala 
        355                 360                 365             


Pro Glu Val Ile Thr Ser Ser Pro Leu Lys 
    370                 375             


<210>  77
<211>  1122
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Squence nuclique codant pour la protine SEQ ID NO:60

<400>  77
atgagatgga gttggatttt tctgctgctg ctgagtatta cctctgctaa cgcaagcaat       60

aaatacaaag atggcgacca gtgtgagacc agtccttgcc agaaccaggg caaatgtaaa      120

gacggcctcg gggaatacac ctgcacctgt ttagaaggat tcgaaggcaa aaactgtgaa      180

ttattcacac ggaagctctg cagcctggac aacggggact gtgaccagtt ctgccacgag      240

gaacagaact ctgtggtgtg ctcctgcgcc cgcgggtaca ccctggctga caacggcaag      300

gcctgcattc ccacagggcc ctacccctgt gggaaacaga ccctggaacg caggaagagg      360

atcgtgggag gccaggaatg caaggacggg gagtgtccct ggcaggccct gctcatcaat      420

gaggaaaacg agggtttctg tggtggaacc attctgagcg agttctacat cctaacggca      480

gcccactgtc tctaccaagc caagagattc aaggtgaggg taggggaccg gaacacggag      540

caggaggagg gcggtgaggc ggtgcacgag gtggaggtgg tcatcaagca caaccggttc      600

acaaaggaga cctatgactt cgacatcgcc gtgctccggc tcaagacccc catcaccttc      660

cgcatgaacg tggcgcctgc ctgcctcccc gagcgtgact gggccgagtc cacgctgatg      720

acgcagaaga cggggattgt gagcggcttc gggcgcaccc acgagaaggg ccggcagtcc      780

accaggctca agatgctgga ggtgccctac gtggaccgca acagctgcaa gctgtccagc      840

agcttcatca tcacccagaa catgttctgt gccggctacg acaccaagca ggaggatgcc      900

tgccaggggg acagcggggg cccgcacgtc acccgcttca aggacaccta cttcgtgaca      960

ggcatcgtca gctggggaga gggctgtgcc cgtaagggga agtacgggat ctacaccaag     1020

gtcaccgcct tcctcaagtg gatcgacagg tccatgaaaa ccaggggctt gcccaaggcc     1080

aagagccatg ccccggaggt cataacgtcc tctccattaa ag                        1122


<210>  78
<211>  1131
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Squence nuclique codant pour la protine SEQ ID NO:61

<400>  78
atgagatgga gttggatttt tctgctgctg ctgagtatta cctctgctaa cgcaagcaat       60

aaatacaaag atggcgacca gtgtgagacc agtccttgcc agaaccaggg caaatgtaaa      120

gacggcctcg gggaatacac ctgcacctgt ttagaaggat tcgaaggcaa aaactgtgaa      180

ttattcacac ggaagctctg cagcctggac aacggggact gtgaccagtt ctgccacgag      240

gaacagaact ctgtggtgtg ctcctgcgcc cgcgggtaca ccctggctga caacggcaag      300

gcctgcattc ccacagggcc ctacccctgt gggaaacaga ccctggaacg caggaagagg      360

aggaagagga tcgtgggagg ccaggaatgc aaggacgggg agtgtccctg gcaggccctg      420

ctcatcaatg aggaaaacga gggtttctgt ggtggaacca ttctgagcga gttctacatc      480

ctaacggcag cccactgtct ctaccaagcc aagagattca aggtgagggt aggggaccgg      540

aacacggagc aggaggaggg cggtgaggcg gtgcacgagg tggaggtggt catcaagcac      600

aaccggttca caaaggagac ctatgacttc gacatcgccg tgctccggct caagaccccc      660

atcaccttcc gcatgaacgt ggcgcctgcc tgcctccccg agcgtgactg ggccgagtcc      720

acgctgatga cgcagaagac ggggattgtg agcggcttcg ggcgcaccca cgagaagggc      780

cggcagtcca ccaggctcaa gatgctggag gtgccctacg tggaccgcaa cagctgcaag      840

ctgtccagca gcttcatcat cacccagaac atgttctgtg ccggctacga caccaagcag      900

gaggatgcct gccaggggga cagcgggggc ccgcacgtca cccgcttcaa ggacacctac      960

ttcgtgacag gcatcgtcag ctggggagag ggctgtgccc gtaaggggaa gtacgggatc     1020

tacaccaagg tcaccgcctt cctcaagtgg atcgacaggt ccatgaaaac caggggcttg     1080

cccaaggcca agagccatgc cccggaggtc ataacgtcct ctccattaaa g              1131


<210>  79
<211>  1119
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Squence nuclique codant pour la protine SEQ ID NO:62

<400>  79
atgagatgga gttggatttt tctgctgctg ctgagtatta cctctgctaa cgcaaacaag       60

tataaagacg gagaccagtg tgagactagc ccttgccaga accaggggaa gtgtaaagat      120

ggactgggcg agtacacctg cacatgtctg gagggattcg aaggcaagaa ttgcgaactg      180

tttactagaa aactgtgtag cctggataac ggcgactgcg atcagttctg tcacgaggaa      240

cagaattcag tggtctgcag ctgtgccagg ggatacaccc tggccgacaa cggcaaggct      300

tgcatcccta ccggccccta tccttgtggg aaacagacac tggagcggag aaagaggatc      360

gtgggcgggc aggagtgcaa ggatggagaa tgtccatggc aggccctgct gattaacgag      420

gaaaatgagg gcttctgcgg aggcactatc ctgtccgaat tttacattct gaccgccgct      480

cattgtctgt atcaggccaa gcggttcaag gtgcgggtcg gcgacagaaa cacagagcag      540

gaggaagggg gagaagctgt gcacgaggtc gaagtggtca tcaagcataa tcgcttcact      600

aaagagacct acgactttga tatcgcagtg ctgagactga agacaccaat tactttcagg      660

atgaatgtcg caccagcatg cctgccagag cgagattggg ctgaatccac cctgatgaca      720

cagaaaactg gcattgtgtc tgggtttgga cggacacacg agaaggggag gcagagcact      780

cgcctgaaaa tgctggaagt gccctacgtc gacaggaact cctgtaagct gagctcctct      840

ttcatcatta cacagaatat gttttgcgca gggtatgaca ctaagcagga ggatgcctgt      900

cagggagact ctggaggacc tcacgtgacc cgcttcaaag atacttattt tgtgaccgga      960

atcgtcagtt ggggagaggg atgcgctcga aaggggaaat acggaatcta taccaaggtg     1020

acagcattcc tgaaatggat tgaccgaagt atgaagaccc ggggcctgcc taaggctaaa     1080

tcacatgcac cagaagtgat cacaagttca cccctgaag                            1119


<210>  80
<211>  1128
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Squence nuclique codant pour la protine SEQ ID NO:63

<400>  80
atgagatgga gttggatttt tctgctgctg ctgagtatta cctctgctaa cgcaaacaag       60

tataaagacg gagaccagtg tgagactagc ccttgccaga accaggggaa gtgtaaagat      120

ggactgggcg agtacacctg cacatgtctg gagggattcg aaggcaagaa ttgcgaactg      180

tttactagaa aactgtgtag cctggataac ggcgactgcg atcagttctg tcacgaggaa      240

cagaattcag tggtctgcag ctgtgccagg ggatacaccc tggccgacaa cggcaaggct      300

tgcatcccta ccggccccta tccttgtggg aaacagacac tggagcggag aaagaggcgc      360

aaacggatcg tgggcgggca ggagtgcaag gatggagaat gtccatggca ggccctgctg      420

attaacgagg aaaatgaggg cttctgcgga ggcactatcc tgtccgaatt ttacattctg      480

accgccgctc attgtctgta tcaggccaag cggttcaagg tgcgggtcgg cgacagaaac      540

acagagcagg aggaaggggg agaagctgtg cacgaggtcg aagtggtcat caagcataat      600

cgcttcacta aagagaccta cgactttgat atcgcagtgc tgagactgaa gacaccaatt      660

actttcagga tgaatgtcgc accagcatgc ctgccagagc gagattgggc tgaatccacc      720

ctgatgacac agaaaactgg cattgtgtct gggtttggac ggacacacga gaaggggagg      780

cagagcactc gcctgaaaat gctggaagtg ccctacgtcg acaggaactc ctgtaagctg      840

agctcctctt tcatcattac acagaatatg ttttgcgcag ggtatgacac taagcaggag      900

gatgcctgtc agggagactc tggaggacct cacgtgaccc gcttcaaaga tacttatttt      960

gtgaccggaa tcgtcagttg gggagaggga tgcgctcgaa aggggaaata cggaatctat     1020

accaaggtga cagcattcct gaaatggatt gaccgaagta tgaagacccg gggcctgcct     1080

aaggctaaat cacatgcacc agaagtgatc acaagttcac ccctgaag                  1128


<210>  81
<211>  1134
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Squence nuclique codant pour la protine SEQ ID NO:65

<400>  81
atgcgatgga gttggatctt tctgctgctg ctgagtatta ccagtgcaaa tgctaacaag       60

tacaaggacg gggaccagtg tgagacctcc ccttgccaga accagggcaa gtgtaaagat      120

ggactgggcg agtacacctg cacatgtctg gagggattcg aaggcaagaa ttgcgaactg      180

tttactagaa aactgtgttc tctggataac ggggactgcg atcagttctg tcacgaggaa      240

cagaattccg tggtctgctc ttgtgccagg gggtacaccc tggccgacaa cggaaaggct      300

tgcatcccta ccggacccta tccttgtggc aaacagacac tggagcgagg gagctccgga      360

cgaagaaagc gaatcgtggg aggacaggag tgcaaagatg gggaatgtcc atggcaggcc      420

ctgctgatta acgaggaaaa tgagggattc tgcggaggca ctatcctgag cgaattttac      480

attctgaccg ccgctcattg tctgtatcag gccaagaggt ttaaagtgcg cgtcggcgac      540

cgaaacacag agcaggagga agggggagaa gctgtgcacg aggtcgaagt ggtcatcaag      600

cataatcgct tcactaaaga gacctacgac tttgatatcg cagtgctgag actgaagaca      660

ccaattactt tcaggatgaa tgtcgcacca gcatgcctgc cagagcgaga ttgggctgaa      720

agtaccctga tgacacagaa gactggaatt gtgtcagggt ttggacggac acacgagaag      780

ggccggcagt ctactagact gaaaatgctg gaagtgccct acgtcgacag gaacagttgt      840

aagctgtcta gttcattcat catcacacag aacatgtttt gcgcaggcta tgacactaag      900

caggaggatg cctgtcaggg ggacagcgga ggacctcacg tgacccgctt caaagatact      960

tattttgtga ccggaatcgt cagctgggga gagggatgcg ctcgaaaggg caaatacggg     1020

atctatacca aggtgacagc attcctgaaa tggattgaca ggagcatgaa gacccgcggc     1080

ctgcctaagg ctaaatccca tgcaccagaa gtgatcacaa gctcccccct gaag           1134


<210>  82
<211>  1152
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Squence nuclique codant pour la protine SEQ ID NO:66

<400>  82
atgagatgga gttggatttt cctgctgctg ctgagtatca ccagtgccaa tgcaaacaag       60

tataaagacg gagaccagtg cgagacatcc ccttgccaga accagggcaa gtgtaaagat      120

gggctgggag agtacacctg cacatgtctg gaggggttcg aaggaaagaa ttgcgaactg      180

tttactagaa aactgtgttc tctggataac ggggactgcg atcagttctg tcacgaggaa      240

cagaattcag tggtctgcag ctgtgccagg gggtacaccc tggccgacaa cggaaaggct      300

tgcatcccca ccggacccta tccttgtggc aaacagacac tggagagagg aggaggagga      360

tccggaggag gagggtctcg gagaaagagg atcgtgggag gccaggagtg caaagatggg      420

gaatgtcctt ggcaggccct gctgattaac gaggaaaatg agggattctg cgggggaact      480

atcctgagcg aattttacat tctgaccgcc gctcactgtc tgtatcaggc caagaggttt      540

aaagtgcgcg tcggcgaccg aaacacagag caggaggaag gcggggaagc tgtgcacgag      600

gtcgaagtgg tcatcaagca taatcgcttc actaaagaga cctacgactt tgatatcgca      660

gtgctgcgac tgaagacacc aattactttc cggatgaatg tcgcaccagc atgcctgcca      720

gagcgagatt gggctgaaag taccctgatg acacagaaga ctggaattgt gtcaggcttt      780

gggcggacac atgagaaggg ccggcagtct actagactga aaatgctgga agtgccttac      840

gtcgacagga acagttgtaa gctgagctcc tctttcatca ttacacagaa tatgttttgc      900

gcaggctatg acactaagca ggaggatgca tgtcaggggg acagcggagg accacacgtg      960

acccgcttca aagatactta ttttgtgacc ggaatcgtca gctggggaga gggatgcgct     1020

cgaaagggca aatacgggat ctataccaag gtgacagcat tcctgaaatg gattgacagg     1080

agcatgaaga cccgcggcct gcctaaggct aaatcccatg caccagaagt gatcacaagt     1140

tcacccctga ag                                                         1152


<210>  83
<211>  1161
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Squence nuclique codant pour la protine SEQ ID NO:67

<400>  83
atgcgatgga gctggatttt tctgctgctg ctgtcaatta catctgccaa cgccaacaag       60

tacaaggacg gggatcagtg cgagacctcc ccttgccaga accagggcaa gtgtaaagat      120

gggctgggag agtacacctg cacatgtctg gaggggttcg aaggaaagaa ttgcgaactg      180

tttactcgca aactgtgttc tctggataac ggggactgcg atcagttctg tcacgaggaa      240

cagaattcag tggtctgcag ctgtgccaga ggctacaccc tggccgacaa cggaaaggct      300

tgcatcccca ccggacccta tccttgtggc aagcagacac tggagcgaag aaaacgagga      360

ggaggaggat ccggaggagg agggtctagg cgcaagcgaa tcgtgggagg ccaggagtgc      420

aaagatgggg aatgtccttg gcaggccctg ctgattaacg aggaaaatga gggattctgc      480

gggggaacta tcctgagcga attttacatt ctgaccgccg ctcactgtct gtatcaggcc      540

aagcggttca aggtgcgggt cggcgacaga aacacagagc aggaggaagg cggggaagct      600

gtgcacgagg tcgaagtggt catcaagcat aatagattca ctaaagagac ctacgacttt      660

gatatcgcag tgctgagact gaagacacca attactttca ggatgaatgt cgcaccagcc      720

tgcctgcccg agagagattg ggctgaaagt accctgatga cacagaaaac tggaattgtg      780

tcaggctttg ggaggacaca tgagaagggc aggcagtcta ctcgcctgaa aatgctggaa      840

gtgccttacg tcgacaggaa cagttgtaag ctgagctcct ctttcatcat tacacagaat      900

atgttttgcg caggctatga cactaagcag gaggatgcat gtcaggggga cagcggagga      960

ccacacgtga cccgcttcaa agatacttat tttgtgaccg gaatcgtcag ctggggagag     1020

ggatgcgctc gaaagggcaa atacgggatc tataccaagg tgacagcatt cctgaaatgg     1080

attgaccgaa gcatgaagac ccggggcctg cctaaggcta aatcccatgc accagaagtg     1140

atcacaagtt cacccctgaa g                                               1161


<210>  84
<211>  1812
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Squence nuclique codant pour la protine SEQ ID NO:68

<400>  84
atgagatgga gttggatttt tctgctgctg ctgagtatta cctctgctaa cgcaagcaat       60

aaatacaaag atggcgacca gtgtgagacc agtccttgcc agaaccaggg caaatgtaaa      120

gacggcctcg gggaatacac ctgcacctgt ttagaaggat tcgaaggcaa aaactgtgaa      180

ttattcacac ggaagctctg cagcctggac aacggggact gtgaccagtt ctgccacgag      240

gaacagaact ctgtggtgtg ctcctgcgcc cgcgggtaca ccctggctga caacggcaag      300

gcctgcattc ccacagggcc ctacccctgt gggaaacaga ccctggaacg caggaagagg      360

aggaagagga tcgtgggagg ccaggaatgc aaggacgggg agtgtccctg gcaggccctg      420

ctcatcaatg aggaaaacga gggtttctgt ggtggaacca ttctgagcga gttctacatc      480

ctaacggcag cccactgtct ctaccaagcc aagagattca aggtgagggt aggggaccgg      540

aacacggagc aggaggaggg cggtgaggcg gtgcacgagg tggaggtggt catcaagcac      600

aaccggttca caaaggagac ctatgacttc gacatcgccg tgctccggct caagaccccc      660

atcaccttcc gcatgaacgt ggcgcctgcc tgcctccccg agcgtgactg ggccgagtcc      720

acgctgatga cgcagaagac ggggattgtg agcggcttcg ggcgcaccca cgagaagggc      780

cggcagtcca ccaggctcaa gatgctggag gtgccctacg tggaccgcaa cagctgcaag      840

ctgtccagca gcttcatcat cacccagaac atgttctgtg ccggctacga caccaagcag      900

gaggatgcct gccaggggga cagcgggggc ccgcacgtca cccgcttcaa ggacacctac      960

ttcgtgacag gcatcgtcag ctggggagag ggctgtgccc gtaaggggaa gtacgggatc     1020

tacaccaagg tcaccgcctt cctcaagtgg atcgacaggt ccatgaaaac caggggcttg     1080

cccaaggcca agagccatgc cccggaggtc ataacgtcct ctccattaaa ggacaagaca     1140

cacacatgcc ctccttgtcc agcccctgag ctgctgggcg gcccctccgt gttcctgttc     1200

ccccccaagc ctaaggatac cctgatgatc agcagaaccc ccgaggtgac ctgcgtggtg     1260

gtggacgtgt cccacgagga tcccgaggtg aagttcaact ggtacgtgga cggcgtggag     1320

gtgcacaacg ctaagaccaa gcccagagag gagcagtaca acagcacata cagagtggtg     1380

tctgtgctga ccgtgctgca ccaggactgg ctgaacggga aggagtacaa gtgcaaggtg     1440

tccaacaagg ccctgcctgc ccctatcgag aagaccatct ctaaggctaa ggggcagccc     1500

cgggagccac aggtgtacac cctgccaccc agccgcgacg agctgaccaa gaaccaggtg     1560

tccctgacat gcctggtgaa gggattctac cccagcgaca tcgccgtgga gtgggagagc     1620

aacggccagc ccgagaacaa ctacaagaca acccctcccg tgctggacag cgatggatcc     1680

ttcttcctgt actccaagct gaccgtggac aagagcaggt ggcagcaggg aaacgtgttc     1740

tcttgttccg tgatgcacga ggctctgcac aaccactaca cccagaagtc cctgagcctg     1800

tctccaggca ag                                                         1812


<210>  85
<211>  1827
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Squence nuclique codant pour la protine SEQ ID NO:69

<400>  85
atgagatgga gttggatttt tctgctgctg ctgagtatta cctctgctaa cgcaagcaat       60

aagtataaag acggggatca gtgcgagacc tccccatgtc agaaccaggg caagtgcaaa      120

gacgggctgg gagagtacac atgcacttgt ctggaggggt tcgaaggaaa gaattgcgaa      180

ctgtttacaa gaaagctgtg cagcctggat aacggcgact gcgatcagtt ctgtcacgag      240

gaacagaata gtgtggtctg ctcatgtgcc agggggtaca ctctggctga caacggaaag      300

gcatgcatcc ctactggacc ttatccatgt ggcaaacaga ccctggagcg gagaaagagg      360

cgcaaacgca tcgtgggcgg gcaggagtgc aaggatggag aatgtccatg gcaggctctg      420

ctgattaacg aggaaaatga gggcttctgc ggaggcacaa tcctgagcga gttctacatt      480

ctgactgccg ctcattgtct gtatcaggct aagcggttca aggtgcgggt cggcgacaga      540

aacaccgagc aggaggaagg gggagaagca gtgcacgagg tcgaagtggt catcaagcat      600

aatcgcttca caaaagagac ttacgacttt gatatcgccg tgctgagact gaagaccccc      660

attacattca ggatgaatgt ggcaccagca tgcctgcctg agcgagattg ggctgaatca      720

actctgatga cccagaaaac aggaattgtg agcggctttg ggcgaactca cgagaagggc      780

aggcagagca cccgcctgaa aatgctggaa gtgccctacg tcgaccggaa cagctgtaag      840

ctgagctcct ctttcatcat tacccagaat atgttttgcg ccggctatga cacaaagcag      900

gaggatgctt gtcaggggga ctccggagga cctcatgtga ccagattcaa agatacatat      960

tttgtgactg gcatcgtctc ttggggagaa ggctgcgcca ggaagggcaa atacgggatc     1020

tatactaagg tgaccgcctt cctgaaatgg attgatcgat ccatgaagac tcggggcctg     1080

ccaaaggcaa aatctcacgc ccccgaagtg atcaccagtt cacctctgaa ggaacctaag     1140

tcttgcgaca aaacccatac atgcccacct tgtccagcac ctgaactgct gggaggacca     1200

tccgtgttcc tgtttccacc caagcccaaa gatacactga tgattagtcg gacccctgag     1260

gtgacatgcg tggtcgtgga tgtctcacac gaggacccag aagtgaagtt taactggtac     1320

gtggacggcg tggaagtcca taatgccaag accaaacctc gcgaggaaca gtacaacagt     1380

acatatcgag tcgtgtcagt gctgactgtc ctgcaccagg attggctgaa cggaaaggag     1440

tataagtgca aagtgagcaa taaggctctg ccagcaccca tcgagaaaac aatttccaag     1500

gcaaaaggcc agccaaggga accccaggtg tacactctgc ctccaagccg cgatgagctg     1560

acaaagaacc aggtgtccct gacttgtctg gtcaaagggt tctatccctc cgacatcgcc     1620

gtggagtggg aatctaatgg acagcctgag aacaattaca agaccacacc ccctgtgctg     1680

gactcagatg ggagcttctt tctgtattct aagctgactg tggacaaaag tagatggcag     1740

cagggaaacg tgttttcttg cagtgtcatg cacgaggccc tgcacaatca ttacacccag     1800

aagtcactga gcctgtcccc aggaaag                                         1827


<210>  86
<211>  1824
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Squence nuclique codant pour la protine SEQ ID NO:70

<400>  86
atgagatgga gttggatttt tctgctgctg ctgagtatta cctctgctaa cgcaaataag       60

tataaagacg gggatcagtg cgagacctct ccttgtcaga accagggcaa gtgcaaagac      120

gggctgggag agtacacatg cacttgtctg gaggggttcg aaggaaagaa ttgcgaactg      180

tttacaagaa aactgtgtag cctggataac ggggactgcg atcagttctg tcacgaggaa      240

cagaattccg tggtctgctc ttgtgcaagg gggtacaccc tggctgacaa cggaaaggca      300

tgcatcccta ctggacctta tccatgtggc aaacagaccc tggagcggag aaagaggcgc      360

aaacgcatcg tgggcgggca ggagtgcaag gatggagaat gtccatggca ggctctgctg      420

attaacgagg aaaatgaggg cttctgcgga ggcacaatcc tgagcgaatt ttacattctg      480

actgccgctc attgtctgta tcaggctaag cggttcaagg tgcgggtcgg cgacagaaac      540

accgagcagg aggaaggggg agaagcagtg cacgaggtcg aagtggtcat caagcataat      600

cgcttcacaa aagagactta cgactttgat atcgccgtgc tgagactgaa gacccccatt      660

acattcagga tgaatgtggc accagcatgc ctgcctgagc gagattgggc tgaatctact      720

ctgatgaccc agaaaacagg aattgtgagt ggctttgggc gaactcacga gaagggcagg      780

cagtctaccc gcctgaaaat gctggaagtg ccctacgtcg accggaacag ctgtaagctg      840

agctcctctt tcatcattac ccagaatatg ttttgcgccg gctatgacac aaagcaggag      900

gatgcttgtc agggggacag cggaggacct catgtgacca gattcaaaga tacatatttt      960

gtgactggca tcgtctcctg gggagaaggc tgcgcaagga agggcaaata cgggatctat     1020

actaaggtga ccgccttcct gaaatggatt gatcgatcaa tgaagactcg gggcctgcca     1080

aaggcaaaaa gccacgcccc cgaagtgatc accagttcac ctctgaagga accaaagagc     1140

tgcgacaaaa cccatacatg cccaccttgt ccagcacctg aactgctggg aggaccatcc     1200

gtgttcctgt ttccacccaa gcccaaagat acactgatga tttcccggac ccctgaggtg     1260

acatgtgtgg tcgtggatgt ctctcacgag gacccagaag tgaagtttaa ctggtacgtg     1320

gacggcgtgg aagtccataa tgccaagacc aaaccccgcg aggaacagta caactccaca     1380

tatcgagtcg tgtctgtgct gactgtcctg caccaggatt ggctgaacgg aaaagagtac     1440

aagtgcaaag tgagtaataa ggctctgcca gcacccatcg agaaaacaat ttccaaggca     1500

aaaggccagc caagggaacc ccaggtgtac actctgcctc caagtcgcga tgagctgaca     1560

aagaaccagg tgtcactgac ttgtctggtc aaagggttct atccctcaga catcgccgtg     1620

gagtgggaaa gcaatggaca gcctgagaac aattacaaga ccacaccccc tgtgctggac     1680

tctgatggga gtttctttct gtatagcaag ctgactgtgg acaaatccag atggcagcag     1740

ggaaacgtgt tttcttgcag tgtcatgcac gaggccctgc acaatcatta cacccagaag     1800

tcactgagcc tgtccccagg aaag                                            1824


<210>  87
<211>  2547
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Squence nuclique codant pour la protine SEQ ID NO:71

<400>  87
atgagatgga gttggatttt tctgctgctg ctgagtatta cctctgctaa cgcaagcaat       60

aagtataaag acggggatca gtgcgagacc tccccatgtc agaaccaggg caagtgcaaa      120

gacgggctgg gagagtacac atgcacttgt ctggaggggt tcgaaggaaa gaattgcgaa      180

ctgtttacaa gaaagctgtg cagcctggat aacggcgact gcgatcagtt ctgtcacgag      240

gaacagaata gtgtggtctg ctcatgtgcc agggggtaca ctctggctga caacggaaag      300

gcatgcatcc ctactggacc ttatccatgt ggcaaacaga ccctggagcg gagaaagagg      360

cgcaaacgca tcgtgggcgg gcaggagtgc aaggatggag aatgtccatg gcaggctctg      420

ctgattaacg aggaaaatga gggcttctgc ggaggcacaa tcctgagcga gttctacatt      480

ctgactgccg ctcattgtct gtatcaggct aagcggttca aggtgcgggt cggcgacaga      540

aacaccgagc aggaggaagg gggagaagca gtgcacgagg tcgaagtggt catcaagcat      600

aatcgcttca caaaagagac ttacgacttt gatatcgccg tgctgagact gaagaccccc      660

attacattca ggatgaatgt ggcaccagca tgcctgcctg agcgagattg ggctgaatca      720

actctgatga cccagaaaac aggaattgtg agcggctttg ggcgaactca cgagaagggc      780

aggcagagca cccgcctgaa aatgctggaa gtgccctacg tcgaccggaa cagctgtaag      840

ctgagctcct ctttcatcat tacccagaat atgttttgcg ccggctatga cacaaagcag      900

gaggatgctt gtcaggggga ctccggagga cctcatgtga ccagattcaa agatacatat      960

tttgtgactg gcatcgtctc ttggggagaa ggctgcgcca ggaagggcaa atacgggatc     1020

tatactaagg tgaccgcctt cctgaaatgg attgatcgat ccatgaagac tcggggcctg     1080

ccaaaggcaa aatctcacgc ccccgaagtg atcaccagtt cacctctgaa ggacaaaacc     1140

catacatgcc caccttgtcc agcacctgaa ctgctgggag gaccatccgt gttcctgttt     1200

ccacccaagc ccaaagatac actgatgatt agtcggaccc ctgaggtgac atgcgtggtc     1260

gtggatgtct cacacgagga cccagaagtg aagtttaact ggtacgtgga cggcgtggaa     1320

gtccataatg ccaagaccaa acctcgcgag gaacagtaca acagtacata tcgagtcgtg     1380

tcagtgctga ctgtcctgca ccaggattgg ctgaacggaa aggagtataa gtgcaaagtg     1440

agcaataagg ctctgccagc acccatcgag aaaacaattt ccaaggcaaa aggccagcca     1500

agggaacccc aggtgtacac tctgcctcca agccgcgatg agctgacaaa gaaccaggtg     1560

tccctgactt gtctggtcaa agggttctat ccctccgaca tcgccgtgga gtgggaatct     1620

aatggacagc ctgagaacaa ttacaagacc acaccccctg tgctggactc agatgggagc     1680

ttctttctgt attctaagct gactgtggac aaaagtagat ggcagcaggg aaacgtgttt     1740

tcttgcagtg tcatgcacga ggccctgcac aatcattaca cccagaagtc actgagcctg     1800

tccccaggag gaggaggagg aagcggagga ggaggctccg ggggaggcgg gtctgagccc     1860

aagagctccg ataaaactca tacctgccca ccctgtcctg ctccagaact gctgggaggc     1920

cctagcgtgt tcctgtttcc tccaaagcca aaagacacac tgatgatttc taggactccc     1980

gaggtgacct gcgtggtggt cgatgtcagt cacgaggacc ctgaagtgaa gttcaactgg     2040

tacgtggatg gagtcgaggt gcacaacgcc aagaccaaac cccgggagga acagtacaac     2100

agcacctata gagtggtctc cgtgctgaca gtcctgcacc aggactggct gaacgggaag     2160

gaatacaagt gcaaagtgtc caataaggcc ctgcccgctc ctatcgaaaa aaccatttct     2220

aaggctaaag gccagccccg ggagccacag gtgtacacac tgcccccttc tcgggatgaa     2280

ctgaccaaga accaggtgag tctgacatgt ctggtcaaag gcttctatcc aagtgacatc     2340

gcagtggagt gggaatcaaa tgggcagccc gagaacaatt acaagactac cccacccgtg     2400

ctggactccg atggctcttt ctttctgtat tcaaagctga ccgtggacaa aagcagatgg     2460

cagcagggga acgtgttcag ctgcagtgtc atgcacgaag cactgcacaa tcattacact     2520

cagaaatcac tgtcactgtc acctgga                                         2547


<210>  88
<211>  2517
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Squence nuclique codant pour la protine SEQ ID NO:72

<400>  88
atgagatgga gttggatttt tctgctgctg ctgagtatta cctctgctaa cgcaagcaat       60

aagtataaag acggggatca gtgcgagacc tccccatgtc agaaccaggg caagtgcaaa      120

gacgggctgg gagagtacac atgcacttgt ctggaggggt tcgaaggaaa gaattgcgaa      180

ctgtttacaa gaaagctgtg cagcctggat aacggcgact gcgatcagtt ctgtcacgag      240

gaacagaata gtgtggtctg ctcatgtgcc agggggtaca ctctggctga caacggaaag      300

gcatgcatcc ctactggacc ttatccatgt ggcaaacaga ccctggagcg gagaaagagg      360

cgcaaacgca tcgtgggcgg gcaggagtgc aaggatggag aatgtccatg gcaggctctg      420

ctgattaacg aggaaaatga gggcttctgc ggaggcacaa tcctgagcga gttctacatt      480

ctgactgccg ctcattgtct gtatcaggct aagcggttca aggtgcgggt cggcgacaga      540

aacaccgagc aggaggaagg gggagaagca gtgcacgagg tcgaagtggt catcaagcat      600

aatcgcttca caaaagagac ttacgacttt gatatcgccg tgctgagact gaagaccccc      660

attacattca ggatgaatgt ggcaccagca tgcctgcctg agcgagattg ggctgaatca      720

actctgatga cccagaaaac aggaattgtg agcggctttg ggcgaactca cgagaagggc      780

aggcagagca cccgcctgaa aatgctggaa gtgccctacg tcgaccggaa cagctgtaag      840

ctgagctcct ctttcatcat tacccagaat atgttttgcg ccggctatga cacaaagcag      900

gaggatgctt gtcaggggga ctccggagga cctcatgtga ccagattcaa agatacatat      960

tttgtgactg gcatcgtctc ttggggagaa ggctgcgcca ggaagggcaa atacgggatc     1020

tatactaagg tgaccgcctt cctgaaatgg attgatcgat ccatgaagac tcggggcctg     1080

ccaaaggcaa aatctcacgc ccccgaagtg atcaccagtt cacctctgaa ggacaaaacc     1140

catacatgcc caccttgtcc agcacctgaa ctgctgggag gaccatccgt gttcctgttt     1200

ccacccaagc ccaaagatac actgatgatt agtcggaccc ctgaggtgac atgcgtggtc     1260

gtggatgtct cacacgagga cccagaagtg aagtttaact ggtacgtgga cggcgtggaa     1320

gtccataatg ccaagaccaa acctcgcgag gaacagtaca acagtacata tcgagtcgtg     1380

tcagtgctga ctgtcctgca ccaggattgg ctgaacggaa aggagtataa gtgcaaagtg     1440

agcaataagg ctctgccagc acccatcgag aaaacaattt ccaaggcaaa aggccagcca     1500

agggaacccc aggtgtacac tctgcctcca agccgcgatg agctgacaaa gaaccaggtg     1560

tccctgactt gtctggtcaa agggttctat ccctccgaca tcgccgtgga gtgggaatct     1620

aatggacagc ctgagaacaa ttacaagacc acaccccctg tgctggactc agatgggagc     1680

ttctttctgt attctaagct gactgtggac aaaagtagat ggcagcaggg aaacgtgttt     1740

tcttgcagtg tcatgcacga ggccctgcac aatcattaca cccagaagtc actgagcctg     1800

tccccaggag gaggaggagg aagcgagccc aagagctccg ataaaactca tacctgccca     1860

ccctgtcctg ctccagaact gctgggaggc cctagcgtgt tcctgtttcc tccaaagcca     1920

aaagacacac tgatgatttc taggactccc gaggtgacct gcgtggtggt cgatgtcagt     1980

cacgaggacc ctgaagtgaa gttcaactgg tacgtggatg gagtcgaggt gcacaacgcc     2040

aagaccaaac cccgggagga acagtacaac agcacctata gagtggtctc cgtgctgaca     2100

gtcctgcacc aggactggct gaacgggaag gaatacaagt gcaaagtgtc caataaggcc     2160

ctgcccgctc ctatcgaaaa aaccatttct aaggctaaag gccagccccg ggagccacag     2220

gtgtacacac tgcccccttc tcgggatgaa ctgaccaaga accaggtgag tctgacatgt     2280

ctggtcaaag gcttctatcc aagtgacatc gcagtggagt gggaatcaaa tgggcagccc     2340

gagaacaatt acaagactac cccacccgtg ctggactccg atggctcttt ctttctgtat     2400

tcaaagctga ccgtggacaa aagcagatgg cagcagggga acgtgttcag ctgcagtgtc     2460

atgcacgaag cactgcacaa tcattacact cagaaatcac tgtcactgtc acctgga        2517


<210>  89
<211>  2559
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Squence nuclique codant pour la protine SEQ ID NO:73

<400>  89
atgcgatggt cctggatttt tctgctgctg ctgagtatta cctctgccaa cgccgataag       60

acacacactt gcccaccctg ccctgcccct gagctgctgg gcgggccaag cgtgttcctg      120

tttcccccta agccaaaaga tacactgatg atcagtagaa ctcccgaagt gacctgcgtg      180

gtcgtggacg tctcacacga ggaccccgaa gtgaagttca actggtacgt ggacggcgtg      240

gaggtccata atgccaagac caaaccccgc gaggaacagt acaactccac ctatcgagtc      300

gtgtctgtgc tgacagtcct gcaccaggat tggctgaacg gcaaggagta taagtgcaaa      360

gtgtctaata aggctctgcc agcacccatc gagaaaacca ttagtaaggc aaaagggcag      420

cctagggaac cacaggtgta cacactgcca cccagtcgcg atgagctgac taagaaccag      480

gtgtcactga cctgtctggt caaaggattc tatccttcag acatcgccgt ggagtgggaa      540

agcaatggcc agccagagaa caattacaag accacacctc cagtgctgga ctctgatgga      600

agtttctttc tgtatagcaa gctgactgtg gacaaatcca gatggcagca gggcaacgtg      660

ttttcttgca gtgtcatgca cgaggccctg cacaatcatt acacccagaa gtcactgagc      720

ctgtcccctg gaggaggagg aggcagtgga ggaggagggt caggaggcgg gggaagcgag      780

ccaaagagct ccgataaaac acatacttgc cccccttgtc ctgctccaga actgctggga      840

ggaccttccg tgttcctgtt tccacccaag cctaaagaca cactgatgat ttccaggaca      900

ccagaagtga cttgtgtcgt ggtcgacgtg tctcatgagg accccgaggt gaagtttaac      960

tggtacgtgg atggagtcga agtgcacaac gccaagacca aaccccggga ggaacagtac     1020

aatagtactt atagagtggt ctcagtgctg accgtcctgc accaggactg gctgaatggc     1080

aaggaatata agtgcaaagt gagcaataag gccctgcccg ctcctatcga aaaaactatt     1140

tccaaggcta aaggccagcc ccgagagcct caggtgtaca ccctgcctcc aagccgggat     1200

gaactgacaa agaaccaggt gtccctgact tgtctggtca aagggttcta tccctccgac     1260

atcgcagtgg agtgggaatc taatggacag cctgagaaca attacaagac taccccccct     1320

gtgctggact cagatgggag cttctttctg tattctaagc tgaccgtgga taaaagtcgc     1380

tggcagcagg gaaatgtgtt ttcttgtagt gtcatgcacg aagccctgca taaccactat     1440

actcaaaagt cactgagcct gagcccagga ggaggaggag gctccaacaa gtataaagac     1500

ggggatcagt gcgagacatc tccttgtcag aatcagggaa agtgtaaaga cggcctgggg     1560

gagtacacct gcacatgtct ggagggcttc gaagggaaga actgcgaact gtttacaaga     1620

aaactgtgta gcctggataa cggcgactgc gatcagttct gtcatgagga acagaattcc     1680

gtggtctgct cttgtgccag gggctacacc ctggctgaca atgggaaggc atgcatccct     1740

accgggccat atccctgtgg aaaacagaca ctggagcgga gaaagaggcg caaacggatc     1800

gtggggggac aggagtgcaa ggatggcgaa tgtccatggc aggctctgct gattaacgag     1860

gaaaatgagg ggttctgcgg cgggactatc ctgtccgaat tttacattct gaccgccgct     1920

cactgtctgt atcaggctaa gcggttcaag gtgcgggtcg gcgacagaaa caccgagcag     1980

gaggaaggag gcgaagcagt gcacgaggtc gaagtggtca tcaagcataa tcgcttcact     2040

aaagagacct acgactttga tatcgccgtg ctgagactga agacacccat tactttcagg     2100

atgaacgtgg caccagcatg cctgccagag cgagattggg ctgaatctac cctgatgaca     2160

cagaaaactg gcattgtgag tggatttggc cgaacacatg agaaggggag gcagtctact     2220

cgcctgaaaa tgctggaagt gccctacgtc gaccggaact cctgtaagct gtctagttca     2280

ttcatcatca cacagaacat gttttgcgcc ggatatgaca ctaagcagga agatgcttgt     2340

cagggcgaca gcggaggacc tcacgtgacc agattcaaag atacctattt tgtgacaggc     2400

atcgtctcct ggggggaggg atgcgcaagg aagggaaaat acggcatcta taccaaggtg     2460

acagccttcc tgaaatggat tgaccgatca atgaagacac ggggcctgcc caaggcaaaa     2520

agccatgccc ctgaagtgat cactagctcc ccactgaaa                            2559


<210>  90
<211>  2550
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Squence nuclique codant pour la protine SEQ ID NO:74

<400>  90
atgcgatggt cctggatttt tctgctgctg ctgagtatta cctctgccaa cgccgataag       60

acacacactt gcccaccctg ccctgcccct gagctgctgg gcgggccaag cgtgttcctg      120

tttcccccta agccaaaaga tacactgatg atcagtagaa ctcccgaagt gacctgcgtg      180

gtcgtggacg tctcacacga ggaccccgaa gtgaagttca actggtacgt ggacggcgtg      240

gaggtccata atgccaagac caaaccccgc gaggaacagt acaactccac ctatcgagtc      300

gtgtctgtgc tgacagtcct gcaccaggat tggctgaacg gcaaggagta taagtgcaaa      360

gtgtctaata aggctctgcc agcacccatc gagaaaacca ttagtaaggc aaaagggcag      420

cctagggaac cacaggtgta cacactgcca cccagtcgcg atgagctgac taagaaccag      480

gtgtcactga cctgtctggt caaaggattc tatccttcag acatcgccgt ggagtgggaa      540

agcaatggcc agccagagaa caattacaag accacacctc cagtgctgga ctctgatgga      600

agtttctttc tgtatagcaa gctgactgtg gacaaatcca gatggcagca gggcaacgtg      660

ttttcttgca gtgtcatgca cgaggccctg cacaatcatt acacccagaa gtcactgagc      720

ctgtcccctg gaggaggagg aggcagtgga ggaggagggt caggaggcgg gggaagcgag      780

ccaaagagct ccgataaaac acatacttgc cccccttgtc ctgctccaga actgctggga      840

ggaccttccg tgttcctgtt tccacccaag cctaaagaca cactgatgat ttccaggaca      900

ccagaagtga cttgtgtcgt ggtcgacgtg tctcatgagg accccgaggt gaagtttaac      960

tggtacgtgg atggagtcga agtgcacaac gccaagacca aaccccggga ggaacagtac     1020

aatagtactt atagagtggt ctcagtgctg accgtcctgc accaggactg gctgaatggc     1080

aaggaatata agtgcaaagt gagcaataag gccctgcccg ctcctatcga aaaaactatt     1140

tccaaggcta aaggccagcc ccgagagcct caggtgtaca ccctgcctcc aagccgggat     1200

gaactgacaa agaaccaggt gtccctgact tgtctggtca aagggttcta tccctccgac     1260

atcgcagtgg agtgggaatc taatggacag cctgagaaca attacaagac taccccccct     1320

gtgctggact cagatgggag cttctttctg tattctaagc tgaccgtgga taaaagtcgc     1380

tggcagcagg gaaatgtgtt ttcttgtagt gtcatgcacg aagccctgca taaccactat     1440

actcaaaagt cactgagcct gagcccagga ggaggaggag gctccaacaa gtataaagac     1500

ggggatcagt gcgagacatc tccttgtcag aatcagggaa agtgtaaaga cggcctgggg     1560

gagtacacct gcacatgtct ggagggcttc gaagggaaga actgcgaact gtttacaaga     1620

aaactgtgta gcctggataa cggcgactgc gatcagttct gtcatgagga acagaattcc     1680

gtggtctgct cttgtgccag gggctacacc ctggctgaca atgggaaggc atgcatccct     1740

accgggccat atccctgtgg aaaacagaca ctggagcgga gaaagaggat cgtgggggga     1800

caggagtgca aggatggcga atgtccatgg caggctctgc tgattaacga ggaaaatgag     1860

gggttctgcg gcgggactat cctgtccgaa ttttacattc tgaccgccgc tcactgtctg     1920

tatcaggcta agcggttcaa ggtgcgggtc ggcgacagaa acaccgagca ggaggaagga     1980

ggcgaagcag tgcacgaggt cgaagtggtc atcaagcata atcgcttcac taaagagacc     2040

tacgactttg atatcgccgt gctgagactg aagacaccca ttactttcag gatgaacgtg     2100

gcaccagcat gcctgccaga gcgagattgg gctgaatcta ccctgatgac acagaaaact     2160

ggcattgtga gtggatttgg ccgaacacat gagaagggga ggcagtctac tcgcctgaaa     2220

atgctggaag tgccctacgt cgaccggaac tcctgtaagc tgtctagttc attcatcatc     2280

acacagaaca tgttttgcgc cggatatgac actaagcagg aagatgcttg tcagggcgac     2340

agcggaggac ctcacgtgac cagattcaaa gatacctatt ttgtgacagg catcgtctcc     2400

tggggggagg gatgcgcaag gaagggaaaa tacggcatct ataccaaggt gacagccttc     2460

ctgaaatgga ttgaccgatc aatgaagaca cggggcctgc ccaaggcaaa aagccatgcc     2520

cctgaagtga tcactagctc cccactgaaa                                      2550


<210>  91
<211>  11
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Linker de l'exemple 20

<400>  91

Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Arg 
1               5                   10      


<210>  92
<211>  8
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Squence dcrite  la figure 9

<400>  92

Arg Lys Arg Ile Val Gly Gly Gln 
1               5               


<210>  93
<211>  12
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Squence dcrite  l'exemple 9

<400>  93

Arg Arg Lys Arg Arg Lys Arg Ile Val Gly Gly Gln 
1               5                   10          


