                         SEQUENCE LISTING

<110>  Baxter International Inc.
       Baxter Healthcare SA
 
<120>  Transformed fungus with vitamin K dependent activity

<130>  R 66208

<150>  EP 13173185.3

<151>  21.06.2013

<160>  9     

<170>  PatentIn version 3.3

<210>  1
<211>  2274
<212>  DNA
<213>  Artificial

<220>
<223>  codon optimized GGCX coding seqeunce

<400>  1
atggccgtct ccgccggctc cgcccgcacc tccccttcct ccgacaaggt ccagaaggac     60

aaggccgagc tcatctccgg ccctcgccag gactcccgca tcggcaagct cctcggcttc    120

gagtggaccg acctctcctc ctggcgccgc ctcgtcaccc tcctcaaccg ccctaccgac    180

cctgcctccc tcgccgtctt ccgcttcctc ttcggcttcc tcatggtcct cgacatccct    240

caggagcgcg gcctctcctc cctcgaccgc aagtacctcg acggcctcga cgtctgccgc    300

ttccctctcc tcgacgccct ccgccctctc cctctcgact ggatgtacct cgtctacacc    360

atcatgttcc tcggcgccct cggcatgatg ctcggcctct gctaccgcat ctcctgcgtc    420

ctcttcctcc tcccttactg gtacgtcttc ctcctcgaca agacctcctg gaacaaccac    480

tcctacctct acggcctcct cgccttccag ctcaccttca tggacgccaa ccactactgg    540

tccgtcgacg gcctcctcaa cgcccaccgc cgcaacgccc acgtccctct ctggaactac    600

gccgtcctcc gcggccagat cttcatcgtc tacttcatcg ccggcgtcaa gaagctcgac    660

gccgactggg tcgagggcta ctccatggag tacctctccc gccactggct cttctcccct    720

ttcaagctcc tcctctccga ggagctcacc tccctcctcg tcgtccactg gggcggcctc    780

ctcctcgacc tctccgccgg cttcctcctc ttcttcgacg tctcccgctc catcggcctc    840

ttcttcgtct cctacttcca ctgcatgaac tcccagctct tctccatcgg catgttctcc    900

tacgtcatgc tcgcctcctc ccctctcttc tgctcccctg agtggcctcg caagctcgtc    960

tcctactgcc ctcgccgcct ccagcagctc ctccctctca aggccgcccc tcagccttcc   1020

gtctcctgcg tctacaagcg ctcccgcggc aagtccggcc agaagcctgg cctccgccac   1080

cagctcggcg ccgccttcac cctcctctac ctcctcgagc agctcttcct cccttactcc   1140

cacttcctca cccagggcta caacaactgg accaacggcc tctacggcta ctcctgggac   1200

atgatggtcc actcccgctc ccaccagcac gtcaagatca cctaccgcga cggccgcacc   1260

ggcgagctcg gctacctcaa ccctggcgtc ttcacccagt cccgccgctg gaaggaccac   1320

gccgacatgc tcaagcagta cgccacctgc ctctcccgcc tcctccctaa gtacaacgtc   1380

accgagcctc agatctactt cgacatctgg gtctccatca acgaccgctt ccagcagcgc   1440

atcttcgacc ctcgcgtcga catcgtccag gccgcctggt cccctttcca gcgcacctcc   1500

tgggtccagc ctctcctcat ggacctctcc ccttggcgcg ccaagctcca ggagatcaag   1560

tcctccctcg acaaccacac cgaggtcgtc ttcatcgccg acttccctgg cctccacctc   1620

gagaacttcg tctccgagga cctcggcaac acctccatcc agctcctcca gggcgaggtc   1680

accgtcgagc tcgtcgccga gcagaagaac cagaccctcc gcgagggcga gaagatgcag   1740

ctccctgccg gcgagtacca caaggtctac accacctccc cttccccttc ctgctacatg   1800

tacgtctacg tcaacaccac cgagctcgcc ctcgagcagg acctcgccta cctccaggag   1860

ctcaaggaga aggtcgagaa cggctccgag accggccctc tccctcctga gctccagcct   1920

ctcctcgagg gcgaggtcaa gggcggccct gagcctaccc ctctcgtcca gaccttcctc   1980

cgccgccagc agcgcctcca ggagatcgag cgccgccgca acaccccttt ccacgagcgc   2040

ttcttccgct tcctcctccg caagctctac gtcttccgcc gctccttcct catgacctgc   2100

atctccctcc gcaacctcat cctcggccgc ccttccctcg agcagctcgc ccaggaggtc   2160

acctacgcca acctccgccc tttcgaggcc gtcggcgagc tcaacccttc caacaccgac   2220

tcctcccact ccaaccctcc tgagtccaac cctgaccctg tccactccga gttc         2274


<210>  2
<211>  2274
<212>  DNA
<213>  Homo sapiens

<400>  2
atggcggtgt ctgccgggtc cgcgcggacc tcgcccagct cagataaagt acagaaagac     60

aaggctgaac tgatctcagg gcccaggcag gacagccgaa tagggaaact cttgggtttt    120

gagtggacag atttgtccag ttggcggagg ctggtgaccc tgctgaatcg accaacggac    180

cctgcaagct tagctgtctt tcgttttctt tttgggttct tgatggtgct agacattccc    240

caggagcggg ggctcagctc tctggaccgg aaataccttg atgggctgga tgtgtgccgc    300

ttccccttgc tggatgccct acgcccactg ccacttgact ggatgtatct tgtctacacc    360

atcatgtttc tgggggcact gggcatgatg ctgggcctgt gctaccggat aagctgtgtg    420

ttattcctgc tgccatactg gtatgtgttt ctcctggaca agacatcatg gaacaaccac    480

tcctatctgt atgggttgtt ggcctttcag ctaacattca tggatgcaaa ccactactgg    540

tctgtggacg gtctgctgaa tgcccatagg aggaatgccc acgtgcccct ttggaactat    600

gcagtgctcc gtggccagat cttcattgtg tacttcattg cgggtgtgaa aaagctggat    660

gcagactggg ttgaaggcta ttccatggaa tatttgtccc ggcactggct cttcagtccc    720

ttcaaactgc tgttgtctga ggagctgact agcctgctgg tcgtgcactg gggtgggctg    780

ctgcttgacc tctcagctgg tttcctgctc ttttttgatg tctcaagatc cattggcctg    840

ttctttgtgt cctacttcca ctgcatgaat tcccagcttt tcagcattgg tatgttctcc    900

tacgtcatgc tggccagcag ccctctcttc tgctcccctg agtggcctcg gaagctggtg    960

tcctactgcc cccgaaggtt gcaacaactg ttgcccctca aggcagcccc tcagcccagt   1020

gtttcctgtg tgtataagag gagccggggc aaaagtggcc agaagccagg gctgcgccat   1080

cagctgggag ctgccttcac cctgctctac ctcctggagc agctattcct gccctattct   1140

cattttctca cccagggcta taacaactgg acaaatgggc tgtatggcta ttcctgggac   1200

atgatggtgc actcccgctc ccaccagcac gtgaagatca cctaccgtga tggccgcact   1260

ggcgaactgg gctaccttaa ccctggggta tttacacaga gtcggcgatg gaaggatcat   1320

gcagacatgc tgaagcaata tgccacttgc ctgagccgcc tgcttcccaa gtataatgtc   1380

actgagcccc agatctactt tgatatttgg gtctccatca atgaccgctt ccagcagagg   1440

atttttgacc ctcgtgtgga catcgtgcag gccgcttggt caccctttca gcgcacatcc   1500

tgggtgcaac cactcttgat ggacctgtct ccctggaggg ccaagttaca ggaaatcaag   1560

agcagcctag acaaccacac tgaggtggtc ttcattgcag atttccctgg actgcacttg   1620

gagaattttg tgagtgaaga cctgggcaac actagcatcc agctgctgca gggggaagtg   1680

actgtggagc ttgtggcaga acagaagaac cagactcttc gagagggaga aaaaatgcag   1740

ttgcctgctg gtgagtacca taaggtgtat acgacatcac ctagcccttc ttgctacatg   1800

tacgtctatg tcaacactac agagcttgca ctggagcaag acctggcata tctgcaagaa   1860

ttaaaggaaa aggtggagaa tggaagtgaa acagggcctc tacccccaga gctgcagcct   1920

ctgttggaag gggaagtaaa agggggccct gagccaacac ctctggttca gacctttctt   1980

agacgccaac aaaggctcca ggagattgaa cgccggcgaa atactccttt ccatgagcga   2040

ttcttccgct tcttgttgcg aaagctctat gtctttcgcc gcagcttcct gatgacttgt   2100

atctcacttc gaaatctgat attaggccgt ccttccctgg agcagctggc ccaggaggtg   2160

acttatgcaa acttgagacc ctttgaggca gttggagaac tgaatccctc aaacacggat   2220

tcttcacatt ctaatcctcc tgagtcaaat cctgatcctg tccactcaga gttc         2274


<210>  3
<211>  758
<212>  PRT
<213>  Homo sapiens

<400>  3

Met Ala Val Ser Ala Gly Ser Ala Arg Thr Ser Pro Ser Ser Asp Lys 
1               5                   10                  15      


Val Gln Lys Asp Lys Ala Glu Leu Ile Ser Gly Pro Arg Gln Asp Ser 
            20                  25                  30          


Arg Ile Gly Lys Leu Leu Gly Phe Glu Trp Thr Asp Leu Ser Ser Trp 
        35                  40                  45              


Arg Arg Leu Val Thr Leu Leu Asn Arg Pro Thr Asp Pro Ala Ser Leu 
    50                  55                  60                  


Ala Val Phe Arg Phe Leu Phe Gly Phe Leu Met Val Leu Asp Ile Pro 
65                  70                  75                  80  


Gln Glu Arg Gly Leu Ser Ser Leu Asp Arg Lys Tyr Leu Asp Gly Leu 
                85                  90                  95      


Asp Val Cys Arg Phe Pro Leu Leu Asp Ala Leu Arg Pro Leu Pro Leu 
            100                 105                 110         


Asp Trp Met Tyr Leu Val Tyr Thr Ile Met Phe Leu Gly Ala Leu Gly 
        115                 120                 125             


Met Met Leu Gly Leu Cys Tyr Arg Ile Ser Cys Val Leu Phe Leu Leu 
    130                 135                 140                 


Pro Tyr Trp Tyr Val Phe Leu Leu Asp Lys Thr Ser Trp Asn Asn His 
145                 150                 155                 160 


Ser Tyr Leu Tyr Gly Leu Leu Ala Phe Gln Leu Thr Phe Met Asp Ala 
                165                 170                 175     


Asn His Tyr Trp Ser Val Asp Gly Leu Leu Asn Ala His Arg Arg Asn 
            180                 185                 190         


Ala His Val Pro Leu Trp Asn Tyr Ala Val Leu Arg Gly Gln Ile Phe 
        195                 200                 205             


Ile Val Tyr Phe Ile Ala Gly Val Lys Lys Leu Asp Ala Asp Trp Val 
    210                 215                 220                 


Glu Gly Tyr Ser Met Glu Tyr Leu Ser Arg His Trp Leu Phe Ser Pro 
225                 230                 235                 240 


Phe Lys Leu Leu Leu Ser Glu Glu Leu Thr Ser Leu Leu Val Val His 
                245                 250                 255     


Trp Gly Gly Leu Leu Leu Asp Leu Ser Ala Gly Phe Leu Leu Phe Phe 
            260                 265                 270         


Asp Val Ser Arg Ser Ile Gly Leu Phe Phe Val Ser Tyr Phe His Cys 
        275                 280                 285             


Met Asn Ser Gln Leu Phe Ser Ile Gly Met Phe Ser Tyr Val Met Leu 
    290                 295                 300                 


Ala Ser Ser Pro Leu Phe Cys Ser Pro Glu Trp Pro Arg Lys Leu Val 
305                 310                 315                 320 


Ser Tyr Cys Pro Arg Arg Leu Gln Gln Leu Leu Pro Leu Lys Ala Ala 
                325                 330                 335     


Pro Gln Pro Ser Val Ser Cys Val Tyr Lys Arg Ser Arg Gly Lys Ser 
            340                 345                 350         


Gly Gln Lys Pro Gly Leu Arg His Gln Leu Gly Ala Ala Phe Thr Leu 
        355                 360                 365             


Leu Tyr Leu Leu Glu Gln Leu Phe Leu Pro Tyr Ser His Phe Leu Thr 
    370                 375                 380                 


Gln Gly Tyr Asn Asn Trp Thr Asn Gly Leu Tyr Gly Tyr Ser Trp Asp 
385                 390                 395                 400 


Met Met Val His Ser Arg Ser His Gln His Val Lys Ile Thr Tyr Arg 
                405                 410                 415     


Asp Gly Arg Thr Gly Glu Leu Gly Tyr Leu Asn Pro Gly Val Phe Thr 
            420                 425                 430         


Gln Ser Arg Arg Trp Lys Asp His Ala Asp Met Leu Lys Gln Tyr Ala 
        435                 440                 445             


Thr Cys Leu Ser Arg Leu Leu Pro Lys Tyr Asn Val Thr Glu Pro Gln 
    450                 455                 460                 


Ile Tyr Phe Asp Ile Trp Val Ser Ile Asn Asp Arg Phe Gln Gln Arg 
465                 470                 475                 480 


Ile Phe Asp Pro Arg Val Asp Ile Val Gln Ala Ala Trp Ser Pro Phe 
                485                 490                 495     


Gln Arg Thr Ser Trp Val Gln Pro Leu Leu Met Asp Leu Ser Pro Trp 
            500                 505                 510         


Arg Ala Lys Leu Gln Glu Ile Lys Ser Ser Leu Asp Asn His Thr Glu 
        515                 520                 525             


Val Val Phe Ile Ala Asp Phe Pro Gly Leu His Leu Glu Asn Phe Val 
    530                 535                 540                 


Ser Glu Asp Leu Gly Asn Thr Ser Ile Gln Leu Leu Gln Gly Glu Val 
545                 550                 555                 560 


Thr Val Glu Leu Val Ala Glu Gln Lys Asn Gln Thr Leu Arg Glu Gly 
                565                 570                 575     


Glu Lys Met Gln Leu Pro Ala Gly Glu Tyr His Lys Val Tyr Thr Thr 
            580                 585                 590         


Ser Pro Ser Pro Ser Cys Tyr Met Tyr Val Tyr Val Asn Thr Thr Glu 
        595                 600                 605             


Leu Ala Leu Glu Gln Asp Leu Ala Tyr Leu Gln Glu Leu Lys Glu Lys 
    610                 615                 620                 


Val Glu Asn Gly Ser Glu Thr Gly Pro Leu Pro Pro Glu Leu Gln Pro 
625                 630                 635                 640 


Leu Leu Glu Gly Glu Val Lys Gly Gly Pro Glu Pro Thr Pro Leu Val 
                645                 650                 655     


Gln Thr Phe Leu Arg Arg Gln Gln Arg Leu Gln Glu Ile Glu Arg Arg 
            660                 665                 670         


Arg Asn Thr Pro Phe His Glu Arg Phe Phe Arg Phe Leu Leu Arg Lys 
        675                 680                 685             


Leu Tyr Val Phe Arg Arg Ser Phe Leu Met Thr Cys Ile Ser Leu Arg 
    690                 695                 700                 


Asn Leu Ile Leu Gly Arg Pro Ser Leu Glu Gln Leu Ala Gln Glu Val 
705                 710                 715                 720 


Thr Tyr Ala Asn Leu Arg Pro Phe Glu Ala Val Gly Glu Leu Asn Pro 
                725                 730                 735     


Ser Asn Thr Asp Ser Ser His Ser Asn Pro Pro Glu Ser Asn Pro Asp 
            740                 745                 750         


Pro Val His Ser Glu Phe 
        755             


<210>  4
<211>  489
<212>  DNA
<213>  Artificial

<220>
<223>  codon optimized VKORC1 coding sequence

<400>  4
atgggctcca cctggggctc ccctggctgg gtccgcctcg ccctctgcct caccggcctc     60

gtcctctccc tctacgccct ccatgtgaag gccgcccgcg cccgcgaccg cgactaccgc    120

gccctctgcg acgtcggcac cgccatctcc tgctcccgcg tcttctcctc ccgctggggc    180

cgcggcttcg gcctcgtcga gcacgtcctc ggccaggact ccatcctcaa ccagtccaac    240

tccatcttcg gctgcatctt ctacaccctc cagctcctcc tcggctgcct ccgcacccgc    300

tgggcctccg tcctcatgct cctctcctcc ctcgtctccc tcgccggctc cgtctacctc    360

gcctggattc tcttcttcgt cctctacgac ttctgcatcg tctgcatcac cacctacgcc    420

atcaacgtct ccctcatgtg gctctccttc cgcaaggtcc aggagcctca gggcaaggcc    480

aagcgccac                                                            489


<210>  5
<211>  489
<212>  DNA
<213>  Homo sapiens

<400>  5
atgggcagca cctgggggag ccctggctgg gtgcggctcg ctctttgcct gacgggctta     60

gtgctctcgc tctacgcgct gcacgtgaag gcggcgcgcg cccgggaccg ggattaccgc    120

gcgctctgcg acgtgggcac cgccatcagc tgttcgcgcg tcttctcctc caggtggggc    180

aggggtttcg ggctggtgga gcatgtgctg ggacaggaca gcatcctcaa tcaatccaac    240

agcatattcg gttgcatctt ctacacacta cagctattgt taggttgcct gcggacacgc    300

tgggcctctg tcctgatgct gctgagctcc ctggtgtctc tcgctggttc tgtctacctg    360

gcctggatcc tgttcttcgt gctctatgat ttctgcattg tttgtatcac cacctatgct    420

atcaacgtga gcctgatgtg gctcagtttc cggaaggtcc aagaacccca gggcaaggct    480

aagaggcac                                                            489


<210>  6
<211>  163
<212>  PRT
<213>  Homo sapiens

<400>  6

Met Gly Ser Thr Trp Gly Ser Pro Gly Trp Val Arg Leu Ala Leu Cys 
1               5                   10                  15      


Leu Thr Gly Leu Val Leu Ser Leu Tyr Ala Leu His Val Lys Ala Ala 
            20                  25                  30          


Arg Ala Arg Asp Arg Asp Tyr Arg Ala Leu Cys Asp Val Gly Thr Ala 
        35                  40                  45              


Ile Ser Cys Ser Arg Val Phe Ser Ser Arg Trp Gly Arg Gly Phe Gly 
    50                  55                  60                  


Leu Val Glu His Val Leu Gly Gln Asp Ser Ile Leu Asn Gln Ser Asn 
65                  70                  75                  80  


Ser Ile Phe Gly Cys Ile Phe Tyr Thr Leu Gln Leu Leu Leu Gly Cys 
                85                  90                  95      


Leu Arg Thr Arg Trp Ala Ser Val Leu Met Leu Leu Ser Ser Leu Val 
            100                 105                 110         


Ser Leu Ala Gly Ser Val Tyr Leu Ala Trp Ile Leu Phe Phe Val Leu 
        115                 120                 125             


Tyr Asp Phe Cys Ile Val Cys Ile Thr Thr Tyr Ala Ile Asn Val Ser 
    130                 135                 140                 


Leu Met Trp Leu Ser Phe Arg Lys Val Gln Glu Pro Gln Gly Lys Ala 
145                 150                 155                 160 


Lys Arg His 
            


<210>  7
<211>  1866
<212>  DNA
<213>  Artificial

<220>
<223>  prothrombin codon optimized coding sequence

<400>  7
atggctcacg tccgcggcct ccagctccct ggctgcctcg ccctcgctgc tctctgctcc     60

ctcgtccact cccagcacgt cttcctcgcc cctcagcagg ctcgctccct cctccagcgc    120

gtccgccgcg ctaacacctt cctcgaggag gtccgcaagg gcaacctcga gcgcgagtgc    180

gtcgaggaga cctgctccta cgaggaggct ttcgaggccc tcgagtcctc caccgccacc    240

gacgtcttct gggctaagta caccgcctgc gagaccgctc gcacccctcg cgacaagctc    300

gctgcctgcc tcgagggcaa ctgcgctgag ggcctcggca ccaactaccg cggccacgtc    360

aacatcaccc gctccggcat cgagtgccag ctctggcgct cccgctaccc tcacaagcct    420

gagatcaact ccaccaccca ccctggcgcc gacctccagg agaacttctg ccgcaaccct    480

gactcctcca ccaccggccc ttggtgctac accaccgacc ctaccgtccg ccgccaggag    540

tgctccatcc ctgtctgcgg ccaggaccag gtcaccgtcg ccatgacccc tcgctccgag    600

ggctcctccg tcaacctctc ccctcctctc gagcagtgcg tccctgaccg cggccagcag    660

taccagggcc gcctcgccgt caccacccac ggcctccctt gcctcgcttg ggcctccgct    720

caggccaagg ctctctccaa gcaccaggac ttcaactccg ccgtccagct cgtcgagaac    780

ttctgccgca accctgacgg cgacgaggag ggcgtctggt gctacgtcgc cggcaagcct    840

ggcgacttcg gctactgcga cctcaactac tgcgaggagg ctgtcgagga ggagaccggc    900

gacggcctcg acgaggactc cgaccgcgcc atcgagggcc gcaccgctac ctccgagtac    960

cagaccttct tcaaccctcg caccttcggc tccggcgagg ctgactgcgg cctccgccct   1020

ctcttcgaga agaagtccct cgaggacaag accgagcgcg agctcctcga gtcctacatc   1080

gacggccgca tcgtcgaggg ctccgacgcc gagatcggca tgtccccttg gcaggtcatg   1140

ctcttccgca agtcccctca ggagctcctc tgcggcgctt ccctcatctc cgaccgctgg   1200

gtcctcaccg ctgcccactg cctcctctac cctccttggg acaagaactt caccgagaac   1260

gacctcctcg tccgcatcgg caagcactcc cgcacccgct acgagcgcaa catcgagaag   1320

atctccatgc tcgagaagat ctacatccac cctcgctaca actggcgcga gaacctcgac   1380

cgcgacatcg ccctcatgaa gctcaagaag cctgtcgcct tctccgacta catccaccct   1440

gtctgcctcc ctgaccgcga gaccgctgcc tccctcctcc aggccggcta caagggccgc   1500

gtcaccggct ggggcaacct caaggagacc tggaccgcta acgtcggcaa gggccagcct   1560

tccgtcctcc aggtcgtcaa cctccctatc gtcgagcgcc ctgtctgcaa ggactccacc   1620

cgcatccgca tcaccgacaa catgttctgc gctggctaca agcctgacga gggcaagcgc   1680

ggcgacgctt gcgagggcga ctccggcggc cctttcgtca tgaagtcccc tttcaacaac   1740

cgctggtacc agatgggcat cgtctcctgg ggcgagggct gcgaccgcga cggcaagtac   1800

ggcttctaca cccacgtctt ccgcctcaag aagtggatcc agaaggtcat cgaccagttc   1860

ggcgag                                                              1866


<210>  8
<211>  1866
<212>  DNA
<213>  Homo sapiens

<400>  8
atggcgcacg tccgaggctt gcagctgcct ggctgcctgg ccctggctgc cctgtgtagc     60

cttgtgcaca gccagcatgt gttcctggct cctcagcaag cacggtcgct gctccagcgg    120

gtccggcgag ccaacacctt cttggaggag gtgcgcaagg gcaacctgga gcgagagtgc    180

gtggaggaga cgtgcagcta cgaggaggcc ttcgaggctc tggagtcctc cacggctacg    240

gatgtgttct gggccaagta cacagcttgt gagacagcga ggacgcctcg agataagctt    300

gctgcatgtc tggaaggtaa ctgtgctgag ggtctgggta cgaactaccg agggcatgtg    360

aacatcaccc ggtcaggcat tgagtgccag ctatggagga gtcgctaccc acataagcct    420

gaaatcaact ccactaccca tcctggggcc gacctacagg agaatttctg ccgcaacccc    480

gacagcagca ccacgggacc ctggtgctac actacagacc ccaccgtgag gaggcaggaa    540

tgcagcatcc ctgtctgtgg ccaggatcaa gtcactgtag cgatgactcc acgctccgaa    600

ggctccagtg tgaatctgtc acctccattg gagcagtgtg tccctgatcg ggggcagcag    660

taccaggggc gcctggcggt gaccacacat gggctcccct gcctggcctg ggccagcgca    720

caggccaagg ccctgagcaa gcaccaggac ttcaactcag ctgtgcagct ggtggagaac    780

ttctgccgca acccagacgg ggatgaggag ggcgtgtggt gctatgtggc cgggaagcct    840

ggcgactttg ggtactgcga cctcaactat tgtgaggagg ccgtggagga ggagacagga    900

gatgggctgg atgaggactc agacagggcc atcgaagggc gtaccgccac cagtgagtac    960

cagactttct tcaatccgag gacctttggc tcgggagagg cagactgtgg gctgcgacct   1020

ctgttcgaga agaagtcgct ggaggacaaa accgaaagag agctcctgga atcctacatc   1080

gacgggcgca ttgtggaggg ctcggatgca gagatcggca tgtcaccttg gcaggtgatg   1140

cttttccgga agagtcccca ggagctgctg tgtggggcca gcctcatcag tgaccgctgg   1200

gtcctcaccg ccgcccactg cctcctgtac ccgccctggg acaagaactt caccgagaat   1260

gaccttctgg tgcgcattgg caagcactcc cgcaccaggt acgagcgaaa cattgaaaag   1320

atatccatgt tggaaaagat ctacatccac cccaggtaca actggcggga gaacctggac   1380

cgggacattg ccctgatgaa gctgaagaag cctgttgcct tcagtgacta cattcaccct   1440

gtgtgtctgc ccgacaggga gacggcagcc agcttgctcc aggctggata caaggggcgg   1500

gtgacaggct ggggcaacct gaaggagacg tggacagcca acgttggtaa ggggcagccc   1560

agtgtcctgc aggtggtgaa cctgcccatt gtggagcggc cggtctgcaa ggactccacc   1620

cggatccgca tcactgacaa catgttctgt gctggttaca agcctgatga agggaaacga   1680

ggggatgcct gtgaaggtga cagtggggga ccctttgtca tgaagagccc ctttaacaac   1740

cgctggtatc aaatgggcat cgtctcatgg ggtgaaggct gtgaccggga tgggaaatat   1800

ggcttctaca cacatgtgtt ccgcctgaag aagtggatac agaaggtcat tgatcagttt   1860

ggagag                                                              1866


<210>  9
<211>  622
<212>  PRT
<213>  Homo sapiens

<400>  9

Met Ala His Val Arg Gly Leu Gln Leu Pro Gly Cys Leu Ala Leu Ala 
1               5                   10                  15      


Ala Leu Cys Ser Leu Val His Ser Gln His Val Phe Leu Ala Pro Gln 
            20                  25                  30          


Gln Ala Arg Ser Leu Leu Gln Arg Val Arg Arg Ala Asn Thr Phe Leu 
        35                  40                  45              


Glu Glu Val Arg Lys Gly Asn Leu Glu Arg Glu Cys Val Glu Glu Thr 
    50                  55                  60                  


Cys Ser Tyr Glu Glu Ala Phe Glu Ala Leu Glu Ser Ser Thr Ala Thr 
65                  70                  75                  80  


Asp Val Phe Trp Ala Lys Tyr Thr Ala Cys Glu Thr Ala Arg Thr Pro 
                85                  90                  95      


Arg Asp Lys Leu Ala Ala Cys Leu Glu Gly Asn Cys Ala Glu Gly Leu 
            100                 105                 110         


Gly Thr Asn Tyr Arg Gly His Val Asn Ile Thr Arg Ser Gly Ile Glu 
        115                 120                 125             


Cys Gln Leu Trp Arg Ser Arg Tyr Pro His Lys Pro Glu Ile Asn Ser 
    130                 135                 140                 


Thr Thr His Pro Gly Ala Asp Leu Gln Glu Asn Phe Cys Arg Asn Pro 
145                 150                 155                 160 


Asp Ser Ser Thr Thr Gly Pro Trp Cys Tyr Thr Thr Asp Pro Thr Val 
                165                 170                 175     


Arg Arg Gln Glu Cys Ser Ile Pro Val Cys Gly Gln Asp Gln Val Thr 
            180                 185                 190         


Val Ala Met Thr Pro Arg Ser Glu Gly Ser Ser Val Asn Leu Ser Pro 
        195                 200                 205             


Pro Leu Glu Gln Cys Val Pro Asp Arg Gly Gln Gln Tyr Gln Gly Arg 
    210                 215                 220                 


Leu Ala Val Thr Thr His Gly Leu Pro Cys Leu Ala Trp Ala Ser Ala 
225                 230                 235                 240 


Gln Ala Lys Ala Leu Ser Lys His Gln Asp Phe Asn Ser Ala Val Gln 
                245                 250                 255     


Leu Val Glu Asn Phe Cys Arg Asn Pro Asp Gly Asp Glu Glu Gly Val 
            260                 265                 270         


Trp Cys Tyr Val Ala Gly Lys Pro Gly Asp Phe Gly Tyr Cys Asp Leu 
        275                 280                 285             


Asn Tyr Cys Glu Glu Ala Val Glu Glu Glu Thr Gly Asp Gly Leu Asp 
    290                 295                 300                 


Glu Asp Ser Asp Arg Ala Ile Glu Gly Arg Thr Ala Thr Ser Glu Tyr 
305                 310                 315                 320 


Gln Thr Phe Phe Asn Pro Arg Thr Phe Gly Ser Gly Glu Ala Asp Cys 
                325                 330                 335     


Gly Leu Arg Pro Leu Phe Glu Lys Lys Ser Leu Glu Asp Lys Thr Glu 
            340                 345                 350         


Arg Glu Leu Leu Glu Ser Tyr Ile Asp Gly Arg Ile Val Glu Gly Ser 
        355                 360                 365             


Asp Ala Glu Ile Gly Met Ser Pro Trp Gln Val Met Leu Phe Arg Lys 
    370                 375                 380                 


Ser Pro Gln Glu Leu Leu Cys Gly Ala Ser Leu Ile Ser Asp Arg Trp 
385                 390                 395                 400 


Val Leu Thr Ala Ala His Cys Leu Leu Tyr Pro Pro Trp Asp Lys Asn 
                405                 410                 415     


Phe Thr Glu Asn Asp Leu Leu Val Arg Ile Gly Lys His Ser Arg Thr 
            420                 425                 430         


Arg Tyr Glu Arg Asn Ile Glu Lys Ile Ser Met Leu Glu Lys Ile Tyr 
        435                 440                 445             


Ile His Pro Arg Tyr Asn Trp Arg Glu Asn Leu Asp Arg Asp Ile Ala 
    450                 455                 460                 


Leu Met Lys Leu Lys Lys Pro Val Ala Phe Ser Asp Tyr Ile His Pro 
465                 470                 475                 480 


Val Cys Leu Pro Asp Arg Glu Thr Ala Ala Ser Leu Leu Gln Ala Gly 
                485                 490                 495     


Tyr Lys Gly Arg Val Thr Gly Trp Gly Asn Leu Lys Glu Thr Trp Thr 
            500                 505                 510         


Ala Asn Val Gly Lys Gly Gln Pro Ser Val Leu Gln Val Val Asn Leu 
        515                 520                 525             


Pro Ile Val Glu Arg Pro Val Cys Lys Asp Ser Thr Arg Ile Arg Ile 
    530                 535                 540                 


Thr Asp Asn Met Phe Cys Ala Gly Tyr Lys Pro Asp Glu Gly Lys Arg 
545                 550                 555                 560 


Gly Asp Ala Cys Glu Gly Asp Ser Gly Gly Pro Phe Val Met Lys Ser 
                565                 570                 575     


Pro Phe Asn Asn Arg Trp Tyr Gln Met Gly Ile Val Ser Trp Gly Glu 
            580                 585                 590         


Gly Cys Asp Arg Asp Gly Lys Tyr Gly Phe Tyr Thr His Val Phe Arg 
        595                 600                 605             


Leu Lys Lys Trp Ile Gln Lys Val Ile Asp Gln Phe Gly Glu 
    610                 615                 620         


