                         SEQUENCE LISTING

<110>  Bayer Pharma AG
 
<120>  Mrg receptor modulators

<130>  BHC 13 1 026

<160>  11    

<170>  PatentIn version 3.5

<210>  1
<211>  77
<212>  PRT
<213>  Homo sapiens

<400>  1

Ser Lys Cys Lys Cys Ser Arg Lys Gly Pro Lys Ile Arg Tyr Ser Asp 
1               5                   10                  15      


Val Lys Lys Leu Glu Met Lys Pro Lys Tyr Pro His Cys Glu Glu Lys 
            20                  25                  30          


Met Val Ile Ile Thr Thr Lys Ser Val Ser Arg Tyr Arg Gly Gln Glu 
        35                  40                  45              


His Cys Leu His Pro Lys Leu Gln Ser Thr Lys Arg Phe Ile Lys Trp 
    50                  55                  60                  


Tyr Asn Ala Trp Asn Glu Lys Arg Arg Val Tyr Glu Glu 
65                  70                  75          


<210>  2
<211>  1989
<212>  DNA
<213>  Homo sapiens

<400>  2
aatgtgtgcg cgctgtggta tgggtgtgca agtgtgcgaa ggcggcgtgt tgtgtgagcg       60

agagggtagc ggatgtgtgt gtgcgtgtgc gcgcgtggct ccgggtgtgc gccgctgcga      120

tagcgggtcc tttcccgggg cgggcgacgg gcgggctggg aaggtctcct cccctcacca      180

cattgagaaa tctcagtgag tcaccgagtg gttctgcata ttaatgagct cgctcgctgc      240

gagggcagga gcggatttaa aagaggccag ggcgggcgga gggaggctgt ggagagagcg      300

cggagacaag cgcagagcgc agcgcacggc cacagacagc cctgggcatc caccgacggc      360

gcagccggag ccagcagagc cggaaggcgc gccccgggca gagaaagccg agcagagctg      420

ggtggcgtct ccgggccgcc gctccgacgg gccagcgccc tccccatgtc cctgctccca      480

cgccgcgccc ctccggtcag catgaggctc ctggcggccg cgctgctcct gctgctgctg      540

gcgctgtaca ccgcgcgtgt ggacgggtcc aaatgcaagt gctcccggaa gggacccaag      600

atccgctaca gcgacgtgaa gaagctggaa atgaagccaa agtacccgca ctgcgaggag      660

aagatggtta tcatcaccac caagagcgtg tccaggtacc gaggtcagga gcactgcctg      720

caccccaagc tgcagagcac caagcgcttc atcaagtggt acaacgcctg gaacgagaag      780

cgcagggtct acgaagaata gggtgaaaaa cctcagaagg gaaaactcca aaccagttgg      840

gagacttgtg caaaggactt tgcagattaa aaaaaaaaaa aaaaaaaaaa aaaaaaaaaa      900

aaaaaaaaaa agcctttctt tctcacaggc ataagacaca aattatatat tgttatgaag      960

cactttttac caacggtcag tttttacatt ttatagctgc gtgcgaaagg cttccagatg     1020

ggagacccat ctctcttgtg ctccagactt catcacaggc tgctttttat caaaaagggg     1080

aaaactcatg cctttccttt ttaaaaaatg cttttttgta tttgtccata cgtcactata     1140

catctgagct ttataagcgc ccgggaggaa caatgagctt ggtggacaca tttcattgca     1200

gtgttgctcc attcctagct tgggaagctt ccgcttagag gtcctggcgc ctcggcacag     1260

ctgccacggg ctctcctggg cttatggccg gtcacagcct cagtgtgact ccacagtggc     1320

ccctgtagcc gggcaagcag gagcaggtct ctctgcatct gttctctgag gaactcaagt     1380

ttggttgcca gaaaaatgtg cttcattccc ccctggttaa tttttacaca ccctaggaaa     1440

catttccaag atcctgtgat ggcgagacaa atgatcctta aagaaggtgt ggggtctttc     1500

ccaacctgag gatttctgaa aggttcacag gttcaatatt taatgcttca gaagcatgtg     1560

aggttcccaa cactgtcagc aaaaacctta ggagaaaact taaaaatata tgaatacatg     1620

cgcaatacac agctacagac acacattctg ttgacaaggg aaaaccttca aagcatgttt     1680

ctttccctca ccacaacaga acatgcagta ctaaagcaat atatttgtga ttccccatgt     1740

aattcttcaa tgttaaacag tgcagtcctc tttcgaaagc taagatgacc atgcgccctt     1800

tcctctgtac atataccctt aagaacgccc cctccacaca ctgcccccca gtatatgccg     1860

cattgtactg ctgtgttata tgctatgtac atgtcagaaa ccattagcat tgcatgcagg     1920

tttcatattc tttctaagat ggaaagtaat aaaatatatt tgaaatgtac caaaaaaaaa     1980

aaaaaaaaa                                                             1989


<210>  3
<211>  330
<212>  PRT
<213>  Homo sapiens

<400>  3

Met Asp Pro Thr Thr Pro Ala Trp Gly Thr Glu Ser Thr Thr Val Asn 
1               5                   10                  15      


Gly Asn Asp Gln Ala Leu Leu Leu Leu Cys Gly Lys Glu Thr Leu Ile 
            20                  25                  30          


Pro Val Phe Leu Ile Leu Phe Ile Ala Leu Val Gly Leu Val Gly Asn 
        35                  40                  45              


Gly Phe Val Leu Trp Leu Leu Gly Phe Arg Met Arg Arg Asn Ala Phe 
    50                  55                  60                  


Ser Val Tyr Val Leu Ser Leu Ala Gly Ala Asp Phe Leu Phe Leu Cys 
65                  70                  75                  80  


Phe Gln Ile Ile Asn Cys Leu Val Tyr Leu Ser Asn Phe Phe Cys Ser 
                85                  90                  95      


Ile Ser Ile Asn Phe Pro Ser Phe Phe Thr Thr Val Met Thr Cys Ala 
            100                 105                 110         


Tyr Leu Ala Gly Leu Ser Met Leu Ser Thr Val Ser Thr Glu Arg Cys 
        115                 120                 125             


Leu Ser Val Leu Trp Pro Ile Trp Tyr Arg Cys Arg Arg Pro Arg His 
    130                 135                 140                 


Leu Ser Ala Val Val Cys Val Leu Leu Trp Ala Leu Ser Leu Leu Leu 
145                 150                 155                 160 


Ser Ile Leu Glu Gly Lys Phe Cys Gly Phe Leu Phe Ser Asp Gly Asp 
                165                 170                 175     


Ser Gly Trp Cys Gln Thr Phe Asp Phe Ile Thr Ala Ala Trp Leu Ile 
            180                 185                 190         


Phe Leu Phe Met Val Leu Cys Gly Ser Ser Leu Ala Leu Leu Val Arg 
        195                 200                 205             


Ile Leu Cys Gly Ser Arg Gly Leu Pro Leu Thr Arg Leu Tyr Leu Thr 
    210                 215                 220                 


Ile Leu Leu Thr Val Leu Val Phe Leu Leu Cys Gly Leu Pro Phe Gly 
225                 230                 235                 240 


Ile Gln Trp Phe Leu Ile Leu Trp Ile Trp Lys Asp Ser Asp Val Leu 
                245                 250                 255     


Phe Cys His Ile His Pro Val Ser Val Val Leu Ser Ser Leu Asn Ser 
            260                 265                 270         


Ser Ala Asn Pro Ile Ile Tyr Phe Phe Val Gly Ser Phe Arg Lys Gln 
        275                 280                 285             


Trp Arg Leu Gln Gln Pro Ile Leu Lys Leu Ala Leu Gln Arg Ala Leu 
    290                 295                 300                 


Gln Asp Ile Ala Glu Val Asp His Ser Glu Gly Cys Phe Arg Gln Gly 
305                 310                 315                 320 


Thr Pro Glu Met Ser Arg Ser Ser Leu Val 
                325                 330 


<210>  4
<211>  2131
<212>  DNA
<213>  Homo sapiens

<400>  4
gtttgccagt cccaggaaag cacttctcaa ctcaccaact ccagtagaaa gaagggtgtt       60

aaggggcacc agtggaggtt ttctgagcat ggatccaacc accccggcct ggggaacaga      120

aagtacaaca gtgaatggaa atgaccaagc ccttcttctg ctttgtggca aggagaccct      180

gatcccggtc ttcctgatcc ttttcattgc cctggtcggg ctggtaggaa acgggtttgt      240

gctctggctc ctgggcttcc gcatgcgcag gaacgccttc tctgtctacg tcctcagcct      300

ggccggggcc gacttcctct tcctctgctt ccagattata aattgcctgg tgtacctcag      360

taacttcttc tgttccatct ccatcaattt ccctagcttc ttcaccactg tgatgacctg      420

tgcctacctt gcaggcctga gcatgctgag caccgtcagc accgagcgct gcctgtccgt      480

cctgtggccc atctggtatc gctgccgccg ccccagacac ctgtcagcgg tcgtgtgtgt      540

cctgctctgg gccctgtccc tactgctgag catcttggaa gggaagttct gtggcttctt      600

atttagtgat ggtgactctg gttggtgtca gacatttgat ttcatcactg cagcgtggct      660

gattttttta ttcatggttc tctgtgggtc cagtctggcc ctgctggtca ggatcctctg      720

tggctccagg ggtctgccac tgaccaggct gtacctgacc atcctgctca cagtgctggt      780

gttcctcctc tgcggcctgc cctttggcat tcagtggttc ctaatattat ggatctggaa      840

ggattctgat gtcttatttt gtcatattca tccagtttca gttgtcctgt catctcttaa      900

cagcagtgcc aaccccatca tttacttctt cgtgggctct tttaggaagc agtggcggct      960

gcagcagccg atcctcaagc tggctctcca gagggctctg caggacattg ctgaggtgga     1020

tcacagtgaa ggatgcttcc gtcagggcac cccggagatg tcgagaagca gtctggtgta     1080

gagatggaca gcctctactt ccatcagata tatgtggctt tgagaggcaa ctttgcccct     1140

gtctgtctga tttgctgaac tttctcagtc ctgattttaa aacagttaag agagtccttg     1200

tgaggattaa gtgagacagt gcctatgaaa caaacactaa gtgcagtgtc tctggaactg     1260

ccttactcac aggcttccac cacagcccta tgagagcttt gccaactctg cggtccatga     1320

ctgttcccac attttaatga atcctacctt tcgcagaagg ctgaaagcag ggcagaaaag     1380

atctacattt ctttggacac tgcacttgat agggactcaa agaatgttat atttttaatt     1440

aatttctttt tctcttccgt acaatttctg tctcaacaaa attagaagaa ttaaatttaa     1500

aactagctcc aaaagagcag tcgtctttca ttttggcaga ccttagaata tccccctagc     1560

ttaataaatc tttgttgaat ggcttaatga atgaataaac tggttaatgt ttaagttaaa     1620

cctctgaaaa gtctccattt accagatttg agtcactaaa tttattgctt tcactacttt     1680

tgaattttgc aaacatgaaa ttaagtttta taattagata aatcaatgtc aacacatatt     1740

taaagtttga ggtacactgt cttcctgtgg tttcctttca catgccatcc cttaaaatcc     1800

cagctacacg ccttcccatt ccttcccctt tgcctttgtt ctaatcttcc ctctctgggg     1860

gctctctaat tcgtcctgga agtttccagt ggtcttatag actccatgtt cttggaggac     1920

aggctgtatg tcagatttac cttttattcc gaagaactcg gagcatttat tttgttaatt     1980

aaattgcaca tatttttaaa agttacgtgt tccacagaat aaaatattaa ttgtaaaaaa     2040

aaaaaaaaaa aaaaaaaaaa aaaaaaaaaa aaaaaaaaaa aaaaaaaaaa aaaaaaaaaa     2100

aaaaaaaaaa aaaaaaaaaa aaaaaaaaaa a                                    2131


<210>  5
<211>  21
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  primer

<400>  5
caggaacgcc ttctctgtct a                                                 21


<210>  6
<211>  18
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  primer

<400>  6
cgtcctcagc ctggccgg                                                     18


<210>  7
<211>  20
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  primer

<400>  7
tggaagcaga ggaagaggaa                                                   20


<210>  8
<211>  20
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  primer

<400>  8
aagttcatcc ggcaccagtc                                                   20


<210>  9
<211>  22
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  primer

<400>  9
cccagaggca ttgacaacag gg                                                22


<210>  10
<211>  21
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  primer

<400>  10
tggcccttga atcttctacg a                                                 21


<210>  11
<211>  99
<212>  PRT
<213>  Mus musculus

<400>  11

Met Arg Leu Leu Ala Ala Ala Leu Leu Leu Leu Leu Leu Ala Leu Cys 
1               5                   10                  15      


Val Arg Ala Leu Asp Gly Ser Lys Cys Lys Cys Ser Arg Lys Gly Pro 
            20                  25                  30          


Lys Ile Arg Tyr Ser Asp Val Lys Lys Leu Glu Met Lys Pro Lys Tyr 
        35                  40                  45              


Pro His Cys Glu Glu Lys Met Val Ile Val Thr Thr Lys Ser Met Ser 
    50                  55                  60                  


Arg Tyr Arg Gly Gln Glu His Cys Leu His Pro Lys Leu Gln Ser Thr 
65                  70                  75                  80  


Lys Arg Phe Ile Lys Trp Tyr Asn Ala Trp Asn Glu Lys Arg Arg Val 
                85                  90                  95      


Tyr Glu Glu 
            


