                         SEQUENCE LISTING

<110>  Hopital Ste-Justine
       Moreau, Alain
       Akoume Ndong, Marie-Yvonne
 
<120>  A METHOD OF INCREASING GIPCR SIGNALISATION IN THE CELLS OF A 
       SCOLIOTIC SUBJECT

<130>  765/14033.121

<140>  N/A
<141>  2014-06-17

<150>  US 61/835,926
<151>  2013-06-17

<160>  26    

<170>  PatentIn version 3.5

<210>  1
<211>  18
<212>  DNA
<213>  Artificial sequence

<220>
<223>  Synthetic Construct

<400>  1
ggaaatcgtg cgtgacat                                                     18


<210>  2
<211>  23
<212>  DNA
<213>  Artificial sequence

<220>
<223>  Synthetic Construct

<400>  2
tcatgatgga gttgaaggta gtt                                               23


<210>  3
<211>  20
<212>  DNA
<213>  Artificial sequence

<220>
<223>  Synthetic Construct

<400>  3
agcatcggat ttgagacctg                                                   20


<210>  4
<211>  20
<212>  DNA
<213>  Artificial sequence

<220>
<223>  Synthetic Construct

<400>  4
tgagtccact tggctttctg                                                   20


<210>  5
<211>  19
<212>  DNA
<213>  Artificial sequence

<220>
<223>  Synthetic Construct

<400>  5
atgtgtcaga cctgccttg                                                    19


<210>  6
<211>  21
<212>  DNA
<213>  Artificial sequence

<220>
<223>  Synthetic Construct

<400>  6
ttgtcccgac tttctacctt g                                                 21


<210>  7
<211>  22
<212>  DNA
<213>  Artificial sequence

<220>
<223>  Synthetic Construct

<400>  7
gtccccacag tagacacata tg                                                22


<210>  8
<211>  20
<212>  DNA
<213>  Artificial sequence

<220>
<223>  Synthetic Construct

<400>  8
tcaactcctc gctttccatg                                                   20


<210>  9
<211>  25
<212>  RNA
<213>  Artificial sequence

<220>
<223>  Synthetic Construct

<400>  9
ccuaagucag caguaggaac auuau                                             25


<210>  10
<211>  25
<212>  RNA
<213>  Artificial sequence

<220>
<223>  Synthetic Construct

<400>  10
ccuaagucag caguaggaac auuau                                             25


<210>  11
<211>  25
<212>  RNA
<213>  Artificial sequence

<220>
<223>  Synthetic Construct

<400>  11
ccuccagcuc auuguugaug cuuau                                             25


<210>  12
<211>  25
<212>  RNA
<213>  Artificial sequence

<220>
<223>  Synthetic Construct

<400>  12
ccgaguaccu gaucaaccug guuca                                             25


<210>  13
<211>  25
<212>  RNA
<213>  Artificial sequence

<220>
<223>  Synthetic Construct

<400>  13
gagaugaaac ugaauuccga gauaa                                             25


<210>  14
<211>  25
<212>  RNA
<213>  Artificial sequence

<220>
<223>  Synthetic Construct

<400>  14
gacuguugag uaugcuccau guaga                                             25


<210>  15
<211>  25
<212>  RNA
<213>  Artificial sequence

<220>
<223>  Synthetic Construct

<400>  15
gaacaaggag ucgucagaaa cucca                                             25


<210>  16
<211>  25
<212>  RNA
<213>  Artificial sequence

<220>
<223>  Synthetic Construct

<400>  16
uccaccaugu cuaugagcuc aucaa                                             25


<210>  17
<211>  25
<212>  RNA
<213>  Artificial sequence

<220>
<223>  Synthetic Construct

<400>  17
ucaggagcag auugcagaau cuuau                                             25


<210>  18
<211>  12
<212>  PRT
<213>  Artificial sequence

<220>
<223>  Synthetic Construct

<400>  18

Gly Arg Gly Asp Ser Val Val Tyr Gly Leu Arg Ser 
1               5                   10          


<210>  19
<211>  5748
<212>  DNA
<213>  homo sapiens

<400>  19
gagaagaaag ccagtgcgtc tctgggcgca ggggccagtg gggctcggag gcacaggcac       60

cccgcgacac tccaggttcc ccgacccacg tccctggcag ccccgattat ttacagcctc      120

agcagagcac ggggcggggg cagaggggcc cgcccgggag ggctgctact tcttaaaacc      180

tctgcgggct gcttagtcac agcccccctt gcttgggtgt gtccttcgct cgctccctcc      240

ctccgtctta ggtcactgtt ttcaacctcg aataaaaact gcagccaact tccgaggcag      300

cctcattgcc cagcggaccc cagcctctgc caggttcggt ccgccatcct cgtcccgtcc      360

tccgccggcc cctgccccgc gcccagggat cctccagctc ctttcgcccg cgccctccgt      420

tcgctccgga caccatggac aagttttggt ggcacgcagc ctggggactc tgcctcgtgc      480

cgctgagcct ggcgcagatc gatttgaata taacctgccg ctttgcaggt gtattccacg      540

tggagaaaaa tggtcgctac agcatctctc ggacggaggc cgctgacctc tgcaaggctt      600

tcaatagcac cttgcccaca atggcccaga tggagaaagc tctgagcatc ggatttgaga      660

cctgcaggta tgggttcata gaagggcacg tggtgattcc ccggatccac cccaactcca      720

tctgtgcagc aaacaacaca ggggtgtaca tcctcacatc caacacctcc cagtatgaca      780

catattgctt caatgcttca gctccacctg aagaagattg tacatcagtc acagacctgc      840

ccaatgcctt tgatggacca attaccataa ctattgttaa ccgtgatggc acccgctatg      900

tccagaaagg agaatacaga acgaatcctg aagacatcta ccccagcaac cctactgatg      960

atgacgtgag cagcggctcc tccagtgaaa ggagcagcac ttcaggaggt tacatctttt     1020

acaccttttc tactgtacac cccatcccag acgaagacag tccctggatc accgacagca     1080

cagacagaat ccctgctacc actttgatga gcactagtgc tacagcaact gagacagcaa     1140

ccaagaggca agaaacctgg gattggtttt catggttgtt tctaccatca gagtcaaaga     1200

atcatcttca cacaacaaca caaatggctg gtacgtcttc aaataccatc tcagcaggct     1260

gggagccaaa tgaagaaaat gaagatgaaa gagacagaca cctcagtttt tctggatcag     1320

gcattgatga tgatgaagat tttatctcca gcaccatttc aaccacacca cgggcttttg     1380

accacacaaa acagaaccag gactggaccc agtggaaccc aagccattca aatccggaag     1440

tgctacttca gacaaccaca aggatgactg atgtagacag aaatggcacc actgcttatg     1500

aaggaaactg gaacccagaa gcacaccctc ccctcattca ccatgagcat catgaggaag     1560

aagagacccc acattctaca agcacaatcc aggcaactcc tagtagtaca acggaagaaa     1620

cagctaccca gaaggaacag tggtttggca acagatggca tgagggatat cgccaaacac     1680

ccaaagaaga ctcccattcg acaacaggga cagctgcagc ctcagctcat accagccatc     1740

caatgcaagg aaggacaaca ccaagcccag aggacagttc ctggactgat ttcttcaacc     1800

caatctcaca ccccatggga cgaggtcatc aagcaggaag aaggatggat atggactcca     1860

gtcatagtat aacgcttcag cctactgcaa atccaaacac aggtttggtg gaagatttgg     1920

acaggacagg acctctttca atgacaacgc agcagagtaa ttctcagagc ttctctacat     1980

cacatgaagg cttggaagaa gataaagacc atccaacaac ttctactctg acatcaagca     2040

ataggaatga tgtcacaggt ggaagaagag acccaaatca ttctgaaggc tcaactactt     2100

tactggaagg ttatacctct cattacccac acacgaagga aagcaggacc ttcatcccag     2160

tgacctcagc taagactggg tcctttggag ttactgcagt tactgttgga gattccaact     2220

ctaatgtcaa tcgttcctta tcaggagacc aagacacatt ccaccccagt ggggggtccc     2280

ataccactca tggatctgaa tcagatggac actcacatgg gagtcaagaa ggtggagcaa     2340

acacaacctc tggtcctata aggacacccc aaattccaga atggctgatc atcttggcat     2400

ccctcttggc cttggctttg attcttgcag tttgcattgc agtcaacagt cgaagaaggt     2460

gtgggcagaa gaaaaagcta gtgatcaaca gtggcaatgg agctgtggag gacagaaagc     2520

caagtggact caacggagag gccagcaagt ctcaggaaat ggtgcatttg gtgaacaagg     2580

agtcgtcaga aactccagac cagtttatga cagctgatga gacaaggaac ctgcagaatg     2640

tggacatgaa gattggggtg taacacctac accattatct tggaaagaaa caaccgttgg     2700

aaacataacc attacaggga gctgggacac ttaacagatg caatgtgcta ctgattgttt     2760

cattgcgaat cttttttagc ataaaatttt ctactctttt tgttttttgt gttttgttct     2820

ttaaagtcag gtccaatttg taaaaacagc attgctttct gaaattaggg cccaattaat     2880

aatcagcaag aatttgatcg ttccagttcc cacttggagg cctttcatcc ctcgggtgtg     2940

ctatggatgg cttctaacaa aaactacaca tatgtattcc tgatcgccaa cctttccccc     3000

accagctaag gacatttccc agggttaata gggcctggtc cctgggagga aatttgaatg     3060

ggtccatttt gcccttccat agcctaatcc ctgggcattg ctttccactg aggttggggg     3120

ttggggtgta ctagttacac atcttcaaca gaccccctct agaaattttt cagatgcttc     3180

tgggagacac ccaaagggtg aagctattta tctgtagtaa actatttatc tgtgtttttg     3240

aaatattaaa ccctggatca gtcctttgat cagtataatt ttttaaagtt actttgtcag     3300

aggcacaaaa gggtttaaac tgattcataa taaatatctg tacttcttcg atcttcacct     3360

tttgtgctgt gattcttcag tttctaaacc agcactgtct gggtccctac aatgtatcag     3420

gaagagctga gaatggtaag gagactcttc taagtcttca tctcagagac cctgagttcc     3480

cactcagacc cactcagcca aatctcatgg aagaccaagg agggcagcac tgtttttgtt     3540

ttttgttttt tgtttttttt ttttgacact gtccaaaggt tttccatcct gtcctggaat     3600

cagagttgga agctgaggag cttcagcctc ttttatggtt taatggccac ctgttctctc     3660

ctgtgaaagg ctttgcaaag tcacattaag tttgcatgac ctgttatccc tggggcccta     3720

tttcatagag gctggcccta ttagtgattt ccaaaaacaa tatggaagtg ccttttgatg     3780

tcttacaata agagaagaag ccaatggaaa tgaaagagat tggcaaaggg gaaggatgat     3840

gccatgtaga tcctgtttga catttttatg gctgtatttg taaacttaaa cacaccagtg     3900

tctgttcttg atgcagttgc tatttaggat gagttaagtg cctggggagt ccctcaaaag     3960

gttaaaggga ttcccatcat tggaatctta tcaccagata ggcaagttta tgaccaaaca     4020

agagagtact ggctttatcc tctaacctca tattttctcc cacttggcaa gtcctttgtg     4080

gcatttattc atcagtcagg gtgtccgatt ggtcctagaa cttccaaagg ctgcttgtca     4140

tagaagccat tgcatctata aagcaacggc tcctgttaaa tggtatctcc tttctgaggc     4200

tcctactaaa agtcatttgt tacctaaact tatgtgctta acaggcaatg cttctcagac     4260

cacaaagcag aaagaagaag aaaagctcct gactaaatca gggctgggct tagacagagt     4320

tgatctgtag aatatcttta aaggagagat gtcaactttc tgcactattc ccagcctctg     4380

ctcctccctg tctaccctct cccctccctc tctccctcca cttcacccca caatcttgaa     4440

aaacttcctt tctcttctgt gaacatcatt ggccagatcc attttcagtg gtctggattt     4500

ctttttattt tcttttcaac ttgaaagaaa ctggacatta ggccactatg tgttgttact     4560

gccactagtg ttcaagtgcc tcttgttttc ccagagattt cctgggtctg ccagaggccc     4620

agacaggctc actcaagctc tttaactgaa aagcaacaag ccactccagg acaaggttca     4680

aaatggttac aacagcctct acctgtcgcc ccagggagaa aggggtagtg atacaagtct     4740

catagccaga gatggttttc cactccttct agatattccc aaaaagaggc tgagacagga     4800

ggttattttc aattttattt tggaattaaa tacttttttc cctttattac tgttgtagtc     4860

cctcacttgg atatacctct gttttcacga tagaaataag ggaggtctag agcttctatt     4920

ccttggccat tgtcaacgga gagctggcca agtcttcaca aacccttgca acattgcctg     4980

aagtttatgg aataagatgt attctcactc ccttgatctc aagggcgtaa ctctggaagc     5040

acagcttgac tacacgtcat ttttaccaat gattttcagg tgacctgggc taagtcattt     5100

aaactgggtc tttataaaag taaaaggcca acatttaatt attttgcaaa gcaacctaag     5160

agctaaagat gtaatttttc ttgcaattgt aaatcttttg tgtctcctga agacttccct     5220

taaaattagc tctgagtgaa aaatcaaaag agacaaaaga catcttcgaa tccatatttc     5280

aagcctggta gaattggctt ttctagcaga acctttccaa aagttttata ttgagattca     5340

taacaacacc aagaattgat tttgtagcca acattcattc aatactgtta tatcagagga     5400

gtaggagaga ggaaacattt gacttatctg gaaaagcaaa atgtacttaa gaataagaat     5460

aacatggtcc attcaccttt atgttataga tatgtctttg tgtaaatcat ttgttttgag     5520

ttttcaaaga atagcccatt gttcattctt gtgctgtaca atgaccactg ttattgttac     5580

tttgactttt cagagcacac ccttcctctg gtttttgtat atttattgat ggatcaataa     5640

taatgaggaa agcatgatat gtatattgct gagttgaaag cacttattgg aaaatattaa     5700

aaggctaaca ttaaaagact aaaggaaaca gaaaaaaaaa aaaaaaaa                  5748


<210>  20
<211>  742
<212>  PRT
<213>  homo sapiens

<400>  20

Met Asp Lys Phe Trp Trp His Ala Ala Trp Gly Leu Cys Leu Val Pro 
1               5                   10                  15      


Leu Ser Leu Ala Gln Ile Asp Leu Asn Ile Thr Cys Arg Phe Ala Gly 
            20                  25                  30          


Val Phe His Val Glu Lys Asn Gly Arg Tyr Ser Ile Ser Arg Thr Glu 
        35                  40                  45              


Ala Ala Asp Leu Cys Lys Ala Phe Asn Ser Thr Leu Pro Thr Met Ala 
    50                  55                  60                  


Gln Met Glu Lys Ala Leu Ser Ile Gly Phe Glu Thr Cys Arg Tyr Gly 
65                  70                  75                  80  


Phe Ile Glu Gly His Val Val Ile Pro Arg Ile His Pro Asn Ser Ile 
                85                  90                  95      


Cys Ala Ala Asn Asn Thr Gly Val Tyr Ile Leu Thr Ser Asn Thr Ser 
            100                 105                 110         


Gln Tyr Asp Thr Tyr Cys Phe Asn Ala Ser Ala Pro Pro Glu Glu Asp 
        115                 120                 125             


Cys Thr Ser Val Thr Asp Leu Pro Asn Ala Phe Asp Gly Pro Ile Thr 
    130                 135                 140                 


Ile Thr Ile Val Asn Arg Asp Gly Thr Arg Tyr Val Gln Lys Gly Glu 
145                 150                 155                 160 


Tyr Arg Thr Asn Pro Glu Asp Ile Tyr Pro Ser Asn Pro Thr Asp Asp 
                165                 170                 175     


Asp Val Ser Ser Gly Ser Ser Ser Glu Arg Ser Ser Thr Ser Gly Gly 
            180                 185                 190         


Tyr Ile Phe Tyr Thr Phe Ser Thr Val His Pro Ile Pro Asp Glu Asp 
        195                 200                 205             


Ser Pro Trp Ile Thr Asp Ser Thr Asp Arg Ile Pro Ala Thr Thr Leu 
    210                 215                 220                 


Met Ser Thr Ser Ala Thr Ala Thr Glu Thr Ala Thr Lys Arg Gln Glu 
225                 230                 235                 240 


Thr Trp Asp Trp Phe Ser Trp Leu Phe Leu Pro Ser Glu Ser Lys Asn 
                245                 250                 255     


His Leu His Thr Thr Thr Gln Met Ala Gly Thr Ser Ser Asn Thr Ile 
            260                 265                 270         


Ser Ala Gly Trp Glu Pro Asn Glu Glu Asn Glu Asp Glu Arg Asp Arg 
        275                 280                 285             


His Leu Ser Phe Ser Gly Ser Gly Ile Asp Asp Asp Glu Asp Phe Ile 
    290                 295                 300                 


Ser Ser Thr Ile Ser Thr Thr Pro Arg Ala Phe Asp His Thr Lys Gln 
305                 310                 315                 320 


Asn Gln Asp Trp Thr Gln Trp Asn Pro Ser His Ser Asn Pro Glu Val 
                325                 330                 335     


Leu Leu Gln Thr Thr Thr Arg Met Thr Asp Val Asp Arg Asn Gly Thr 
            340                 345                 350         


Thr Ala Tyr Glu Gly Asn Trp Asn Pro Glu Ala His Pro Pro Leu Ile 
        355                 360                 365             


His His Glu His His Glu Glu Glu Glu Thr Pro His Ser Thr Ser Thr 
    370                 375                 380                 


Ile Gln Ala Thr Pro Ser Ser Thr Thr Glu Glu Thr Ala Thr Gln Lys 
385                 390                 395                 400 


Glu Gln Trp Phe Gly Asn Arg Trp His Glu Gly Tyr Arg Gln Thr Pro 
                405                 410                 415     


Lys Glu Asp Ser His Ser Thr Thr Gly Thr Ala Ala Ala Ser Ala His 
            420                 425                 430         


Thr Ser His Pro Met Gln Gly Arg Thr Thr Pro Ser Pro Glu Asp Ser 
        435                 440                 445             


Ser Trp Thr Asp Phe Phe Asn Pro Ile Ser His Pro Met Gly Arg Gly 
    450                 455                 460                 


His Gln Ala Gly Arg Arg Met Asp Met Asp Ser Ser His Ser Ile Thr 
465                 470                 475                 480 


Leu Gln Pro Thr Ala Asn Pro Asn Thr Gly Leu Val Glu Asp Leu Asp 
                485                 490                 495     


Arg Thr Gly Pro Leu Ser Met Thr Thr Gln Gln Ser Asn Ser Gln Ser 
            500                 505                 510         


Phe Ser Thr Ser His Glu Gly Leu Glu Glu Asp Lys Asp His Pro Thr 
        515                 520                 525             


Thr Ser Thr Leu Thr Ser Ser Asn Arg Asn Asp Val Thr Gly Gly Arg 
    530                 535                 540                 


Arg Asp Pro Asn His Ser Glu Gly Ser Thr Thr Leu Leu Glu Gly Tyr 
545                 550                 555                 560 


Thr Ser His Tyr Pro His Thr Lys Glu Ser Arg Thr Phe Ile Pro Val 
                565                 570                 575     


Thr Ser Ala Lys Thr Gly Ser Phe Gly Val Thr Ala Val Thr Val Gly 
            580                 585                 590         


Asp Ser Asn Ser Asn Val Asn Arg Ser Leu Ser Gly Asp Gln Asp Thr 
        595                 600                 605             


Phe His Pro Ser Gly Gly Ser His Thr Thr His Gly Ser Glu Ser Asp 
    610                 615                 620                 


Gly His Ser His Gly Ser Gln Glu Gly Gly Ala Asn Thr Thr Ser Gly 
625                 630                 635                 640 


Pro Ile Arg Thr Pro Gln Ile Pro Glu Trp Leu Ile Ile Leu Ala Ser 
                645                 650                 655     


Leu Leu Ala Leu Ala Leu Ile Leu Ala Val Cys Ile Ala Val Asn Ser 
            660                 665                 670         


Arg Arg Arg Cys Gly Gln Lys Lys Lys Leu Val Ile Asn Ser Gly Asn 
        675                 680                 685             


Gly Ala Val Glu Asp Arg Lys Pro Ser Gly Leu Asn Gly Glu Ala Ser 
    690                 695                 700                 


Lys Ser Gln Glu Met Val His Leu Val Asn Lys Glu Ser Ser Glu Thr 
705                 710                 715                 720 


Pro Asp Gln Phe Met Thr Ala Asp Glu Thr Arg Asn Leu Gln Asn Val 
                725                 730                 735     


Asp Met Lys Ile Gly Val 
            740         


<210>  21
<211>  798
<212>  PRT
<213>  homo sapiens

<400>  21

Met Asn Leu Gln Pro Ile Phe Trp Ile Gly Leu Ile Ser Ser Val Cys 
1               5                   10                  15      


Cys Val Phe Ala Gln Thr Asp Glu Asn Arg Cys Leu Lys Ala Asn Ala 
            20                  25                  30          


Lys Ser Cys Gly Glu Cys Ile Gln Ala Gly Pro Asn Cys Gly Trp Cys 
        35                  40                  45              


Thr Asn Ser Thr Phe Leu Gln Glu Gly Met Pro Thr Ser Ala Arg Cys 
    50                  55                  60                  


Asp Asp Leu Glu Ala Leu Lys Lys Lys Gly Cys Pro Pro Asp Asp Ile 
65                  70                  75                  80  


Glu Asn Pro Arg Gly Ser Lys Asp Ile Lys Lys Asn Lys Asn Val Thr 
                85                  90                  95      


Asn Arg Ser Lys Gly Thr Ala Glu Lys Leu Lys Pro Glu Asp Ile Thr 
            100                 105                 110         


Gln Ile Gln Pro Gln Gln Leu Val Leu Arg Leu Arg Ser Gly Glu Pro 
        115                 120                 125             


Gln Thr Phe Thr Leu Lys Phe Lys Arg Ala Glu Asp Tyr Pro Ile Asp 
    130                 135                 140                 


Leu Tyr Tyr Leu Met Asp Leu Ser Tyr Ser Met Lys Asp Asp Leu Glu 
145                 150                 155                 160 


Asn Val Lys Ser Leu Gly Thr Asp Leu Met Asn Glu Met Arg Arg Ile 
                165                 170                 175     


Thr Ser Asp Phe Arg Ile Gly Phe Gly Ser Phe Val Glu Lys Thr Val 
            180                 185                 190         


Met Pro Tyr Ile Ser Thr Thr Pro Ala Lys Leu Arg Asn Pro Cys Thr 
        195                 200                 205             


Ser Glu Gln Asn Cys Thr Ser Pro Phe Ser Tyr Lys Asn Val Leu Ser 
    210                 215                 220                 


Leu Thr Asn Lys Gly Glu Val Phe Asn Glu Leu Val Gly Lys Gln Arg 
225                 230                 235                 240 


Ile Ser Gly Asn Leu Asp Ser Pro Glu Gly Gly Phe Asp Ala Ile Met 
                245                 250                 255     


Gln Val Ala Val Cys Gly Ser Leu Ile Gly Trp Arg Asn Val Thr Arg 
            260                 265                 270         


Leu Leu Val Phe Ser Thr Asp Ala Gly Phe His Phe Ala Gly Asp Gly 
        275                 280                 285             


Lys Leu Gly Gly Ile Val Leu Pro Asn Asp Gly Gln Cys His Leu Glu 
    290                 295                 300                 


Asn Asn Met Tyr Thr Met Ser His Tyr Tyr Asp Tyr Pro Ser Ile Ala 
305                 310                 315                 320 


His Leu Val Gln Lys Leu Ser Glu Asn Asn Ile Gln Thr Ile Phe Ala 
                325                 330                 335     


Val Thr Glu Glu Phe Gln Pro Val Tyr Lys Glu Leu Lys Asn Leu Ile 
            340                 345                 350         


Pro Lys Ser Ala Val Gly Thr Leu Ser Ala Asn Ser Ser Asn Val Ile 
        355                 360                 365             


Gln Leu Ile Ile Asp Ala Tyr Asn Ser Leu Ser Ser Glu Val Ile Leu 
    370                 375                 380                 


Glu Asn Gly Lys Leu Ser Glu Gly Val Thr Ile Ser Tyr Lys Ser Tyr 
385                 390                 395                 400 


Cys Lys Asn Gly Val Asn Gly Thr Gly Glu Asn Gly Arg Lys Cys Ser 
                405                 410                 415     


Asn Ile Ser Ile Gly Asp Glu Val Gln Phe Glu Ile Ser Ile Thr Ser 
            420                 425                 430         


Asn Lys Cys Pro Lys Lys Asp Ser Asp Ser Phe Lys Ile Arg Pro Leu 
        435                 440                 445             


Gly Phe Thr Glu Glu Val Glu Val Ile Leu Gln Tyr Ile Cys Glu Cys 
    450                 455                 460                 


Glu Cys Gln Ser Glu Gly Ile Pro Glu Ser Pro Lys Cys His Glu Gly 
465                 470                 475                 480 


Asn Gly Thr Phe Glu Cys Gly Ala Cys Arg Cys Asn Glu Gly Arg Val 
                485                 490                 495     


Gly Arg His Cys Glu Cys Ser Thr Asp Glu Val Asn Ser Glu Asp Met 
            500                 505                 510         


Asp Ala Tyr Cys Arg Lys Glu Asn Ser Ser Glu Ile Cys Ser Asn Asn 
        515                 520                 525             


Gly Glu Cys Val Cys Gly Gln Cys Val Cys Arg Lys Arg Asp Asn Thr 
    530                 535                 540                 


Asn Glu Ile Tyr Ser Gly Lys Phe Cys Glu Cys Asp Asn Phe Asn Cys 
545                 550                 555                 560 


Asp Arg Ser Asn Gly Leu Ile Cys Gly Gly Asn Gly Val Cys Lys Cys 
                565                 570                 575     


Arg Val Cys Glu Cys Asn Pro Asn Tyr Thr Gly Ser Ala Cys Asp Cys 
            580                 585                 590         


Ser Leu Asp Thr Ser Thr Cys Glu Ala Ser Asn Gly Gln Ile Cys Asn 
        595                 600                 605             


Gly Arg Gly Ile Cys Glu Cys Gly Val Cys Lys Cys Thr Asp Pro Lys 
    610                 615                 620                 


Phe Gln Gly Gln Thr Cys Glu Met Cys Gln Thr Cys Leu Gly Val Cys 
625                 630                 635                 640 


Ala Glu His Lys Glu Cys Val Gln Cys Arg Ala Phe Asn Lys Gly Glu 
                645                 650                 655     


Lys Lys Asp Thr Cys Thr Gln Glu Cys Ser Tyr Phe Asn Ile Thr Lys 
            660                 665                 670         


Val Glu Ser Arg Asp Lys Leu Pro Gln Pro Val Gln Pro Asp Pro Val 
        675                 680                 685             


Ser His Cys Lys Glu Lys Asp Val Asp Asp Cys Trp Phe Tyr Phe Thr 
    690                 695                 700                 


Tyr Ser Val Asn Gly Asn Asn Glu Val Met Val His Val Val Glu Asn 
705                 710                 715                 720 


Pro Glu Cys Pro Thr Gly Pro Asp Ile Ile Pro Ile Val Ala Gly Val 
                725                 730                 735     


Val Ala Gly Ile Val Leu Ile Gly Leu Ala Leu Leu Leu Ile Trp Lys 
            740                 745                 750         


Leu Leu Met Ile Ile His Asp Arg Arg Glu Phe Ala Lys Phe Glu Lys 
        755                 760                 765             


Glu Lys Met Asn Ala Lys Trp Asp Thr Gly Glu Asn Pro Ile Tyr Lys 
    770                 775                 780                 


Ser Ala Val Thr Thr Val Val Asn Pro Lys Tyr Glu Gly Lys 
785                 790                 795             


<210>  22
<211>  3879
<212>  DNA
<213>  homo sapiens

<400>  22
atcagacgcg cagaggaggc ggggccgcgg ctggtttcct gccggggggc ggctctgggc       60

cgccgagtcc cctcctcccg cccctgagga ggaggagccg ccgccacccg ccgcgcccga      120

cacccgggag gccccgccag cccgcgggag aggcccagcg ggagtcgcgg aacagcaggc      180

ccgagcccac cgcgccgggc cccggacgcc gcgcggaaaa gatgaattta caaccaattt      240

tctggattgg actgatcagt tcagtttgct gtgtgtttgc tcaaacagat gaaaatagat      300

gtttaaaagc aaatgccaaa tcatgtggag aatgtataca agcagggcca aattgtgggt      360

ggtgcacaaa ttcaacattt ttacaggaag gaatgcctac ttctgcacga tgtgatgatt      420

tagaagcctt aaaaaagaag ggttgccctc cagatgacat agaaaatccc agaggctcca      480

aagatataaa gaaaaataaa aatgtaacca accgtagcaa aggaacagca gagaagctca      540

agccagagga tattactcag atccaaccac agcagttggt tttgcgatta agatcagggg      600

agccacagac atttacatta aaattcaaga gagctgaaga ctatcccatt gacctctact      660

accttatgga cctgtcttac tcaatgaaag acgatttgga gaatgtaaaa agtcttggaa      720

cagatctgat gaatgaaatg aggaggatta cttcggactt cagaattgga tttggctcat      780

ttgtggaaaa gactgtgatg ccttacatta gcacaacacc agctaagctc aggaaccctt      840

gcacaagtga acagaactgc accagcccat ttagctacaa aaatgtgctc agtcttacta      900

ataaaggaga agtatttaat gaacttgttg gaaaacagcg catatctgga aatttggatt      960

ctccagaagg tggtttcgat gccatcatgc aagttgcagt ttgtggatca ctgattggct     1020

ggaggaatgt tacacggctg ctggtgtttt ccacagatgc cgggtttcac tttgctggag     1080

atgggaaact tggtggcatt gttttaccaa atgatggaca atgtcacctg gaaaataata     1140

tgtacacaat gagccattat tatgattatc cttctattgc tcaccttgtc cagaaactga     1200

gtgaaaataa tattcagaca atttttgcag ttactgaaga atttcagcct gtttacaagg     1260

agctgaaaaa cttgatccct aagtcagcag taggaacatt atctgcaaat tctagcaatg     1320

taattcagtt gatcattgat gcatacaatt ccctttcctc agaagtcatt ttggaaaacg     1380

gcaaattgtc agaaggcgta acaataagtt acaaatctta ctgcaagaac ggggtgaatg     1440

gaacagggga aaatggaaga aaatgttcca atatttccat tggagatgag gttcaatttg     1500

aaattagcat aacttcaaat aagtgtccaa aaaaggattc tgacagcttt aaaattaggc     1560

ctctgggctt tacggaggaa gtagaggtta ttcttcagta catctgtgaa tgtgaatgcc     1620

aaagcgaagg catccctgaa agtcccaagt gtcatgaagg aaatgggaca tttgagtgtg     1680

gcgcgtgcag gtgcaatgaa gggcgtgttg gtagacattg tgaatgcagc acagatgaag     1740

ttaacagtga agacatggat gcttactgca ggaaagaaaa cagttcagaa atctgcagta     1800

acaatggaga gtgcgtctgc ggacagtgtg tttgtaggaa gagggataat acaaatgaaa     1860

tttattctgg caaattctgc gagtgtgata atttcaactg tgatagatcc aatggcttaa     1920

tttgtggagg aaatggtgtt tgcaagtgtc gtgtgtgtga gtgcaacccc aactacactg     1980

gcagtgcatg tgactgttct ttggatacta gtacttgtga agccagcaac ggacagatct     2040

gcaatggccg gggcatctgc gagtgtggtg tctgtaagtg tacagatccg aagtttcaag     2100

ggcaaacgtg tgagatgtgt cagacctgcc ttggtgtctg tgctgagcat aaagaatgtg     2160

ttcagtgcag agccttcaat aaaggagaaa agaaagacac atgcacacag gaatgttcct     2220

attttaacat taccaaggta gaaagtcggg acaaattacc ccagccggtc caacctgatc     2280

ctgtgtccca ttgtaaggag aaggatgttg acgactgttg gttctatttt acgtattcag     2340

tgaatgggaa caacgaggtc atggttcatg ttgtggagaa tccagagtgt cccactggtc     2400

cagacatcat tccaattgta gctggtgtgg ttgctggaat tgttcttatt ggccttgcat     2460

tactgctgat atggaagctt ttaatgataa ttcatgacag aagggagttt gctaaatttg     2520

aaaaggagaa aatgaatgcc aaatgggaca cgggtgaaaa tcctatttat aagagtgccg     2580

taacaactgt ggtcaatccg aagtatgagg gaaaatgagt actgcccgtg caaatcccac     2640

aacactgaat gcaaagtagc aatttccata gtcacagtta ggtagcttta gggcaatatt     2700

gccatggttt tactcatgtg caggttttga aaatgtacaa tatgtataat ttttaaaatg     2760

ttttattatt ttgaaaataa tgttgtaatt catgccaggg actgacaaaa gacttgagac     2820

aggatggtta ctcttgtcag ctaaggtcac attgtgcctt tttgaccttt tcttcctgga     2880

ctattgaaat caagcttatt ggattaagtg atatttctat agcgattgaa agggcaatag     2940

ttaaagtaat gagcatgatg agagtttctg ttaatcatgt attaaaactg atttttagct     3000

ttacaaatat gtcagtttgc agttatgcag aatccaaagt aaatgtcctg ctagctagtt     3060

aaggattgtt ttaaatctgt tattttgcta tttgcctgtt agacatgact gatgacatat     3120

ctgaaagaca agtatgttga gagttgctgg tgtaaaatac gtttgaaata gttgatctac     3180

aaaggccatg ggaaaaattc agagagttag gaaggaaaaa ccaatagctt taaaacctgt     3240

gtgccatttt aagagttact taatgtttgg taacttttat gccttcactt tacaaattca     3300

agccttagat aaaagaaccg agcaattttc tgctaaaaag tccttgattt agcactattt     3360

acatacaggc catactttac aaagtatttg ctgaatgggg accttttgag ttgaatttat     3420

tttattattt ttattttgtt taatgtctgg tgctttctgt cacctcttct aatcttttaa     3480

tgtatttgtt tgcaattttg gggtaagact ttttttatga gtactttttc tttgaagttt     3540

tagcggtcaa tttgcctttt taatgaacat gtgaagttat actgtggcta tgcaacagct     3600

ctcacctacg cgagtcttac tttgagttag tgccataaca gaccactgta tgtttacttc     3660

tcaccatttg agttgcccat cttgtttcac actagtcaca ttcttgtttt aagtgccttt     3720

agttttaaca gttcactttt tacagtgcta tttactgaag ttatttatta aatatgccta     3780

aaatacttaa atcggatgtc ttgactctga tgtattttat caggttgtgt gcatgaaatt     3840

tttatagatt aaagaagttg aggaaaagca aaaaaaaaa                            3879


<210>  23
<211>  1049
<212>  PRT
<213>  homo sapiens

<400>  23

Met Gly Ser Arg Thr Pro Glu Ser Pro Leu His Ala Val Gln Leu Arg 
1               5                   10                  15      


Trp Gly Pro Arg Arg Arg Pro Pro Leu Leu Pro Leu Leu Leu Leu Leu 
            20                  25                  30          


Leu Pro Pro Pro Pro Arg Val Gly Gly Phe Asn Leu Asp Ala Glu Ala 
        35                  40                  45              


Pro Ala Val Leu Ser Gly Pro Pro Gly Ser Phe Phe Gly Phe Ser Val 
    50                  55                  60                  


Glu Phe Tyr Arg Pro Gly Thr Asp Gly Val Ser Val Leu Val Gly Ala 
65                  70                  75                  80  


Pro Lys Ala Asn Thr Ser Gln Pro Gly Val Leu Gln Gly Gly Ala Val 
                85                  90                  95      


Tyr Leu Cys Pro Trp Gly Ala Ser Pro Thr Gln Cys Thr Pro Ile Glu 
            100                 105                 110         


Phe Asp Ser Lys Gly Ser Arg Leu Leu Glu Ser Ser Leu Ser Ser Ser 
        115                 120                 125             


Glu Gly Glu Glu Pro Val Glu Tyr Lys Ser Leu Gln Trp Phe Gly Ala 
    130                 135                 140                 


Thr Val Arg Ala His Gly Ser Ser Ile Leu Ala Cys Ala Pro Leu Tyr 
145                 150                 155                 160 


Ser Trp Arg Thr Glu Lys Glu Pro Leu Ser Asp Pro Val Gly Thr Cys 
                165                 170                 175     


Tyr Leu Ser Thr Asp Asn Phe Thr Arg Ile Leu Glu Tyr Ala Pro Cys 
            180                 185                 190         


Arg Ser Asp Phe Ser Trp Ala Ala Gly Gln Gly Tyr Cys Gln Gly Gly 
        195                 200                 205             


Phe Ser Ala Glu Phe Thr Lys Thr Gly Arg Val Val Leu Gly Gly Pro 
    210                 215                 220                 


Gly Ser Tyr Phe Trp Gln Gly Gln Ile Leu Ser Ala Thr Gln Glu Gln 
225                 230                 235                 240 


Ile Ala Glu Ser Tyr Tyr Pro Glu Tyr Leu Ile Asn Leu Val Gln Gly 
                245                 250                 255     


Gln Leu Gln Thr Arg Gln Ala Ser Ser Ile Tyr Asp Asp Ser Tyr Leu 
            260                 265                 270         


Gly Tyr Ser Val Ala Val Gly Glu Phe Ser Gly Asp Asp Thr Glu Asp 
        275                 280                 285             


Phe Val Ala Gly Val Pro Lys Gly Asn Leu Thr Tyr Gly Tyr Val Thr 
    290                 295                 300                 


Ile Leu Asn Gly Ser Asp Ile Arg Ser Leu Tyr Asn Phe Ser Gly Glu 
305                 310                 315                 320 


Gln Met Ala Ser Tyr Phe Gly Tyr Ala Val Ala Ala Thr Asp Val Asn 
                325                 330                 335     


Gly Asp Gly Leu Asp Asp Leu Leu Val Gly Ala Pro Leu Leu Met Asp 
            340                 345                 350         


Arg Thr Pro Asp Gly Arg Pro Gln Glu Val Gly Arg Val Tyr Val Tyr 
        355                 360                 365             


Leu Gln His Pro Ala Gly Ile Glu Pro Thr Pro Thr Leu Thr Leu Thr 
    370                 375                 380                 


Gly His Asp Glu Phe Gly Arg Phe Gly Ser Ser Leu Thr Pro Leu Gly 
385                 390                 395                 400 


Asp Leu Asp Gln Asp Gly Tyr Asn Asp Val Ala Ile Gly Ala Pro Phe 
                405                 410                 415     


Gly Gly Glu Thr Gln Gln Gly Val Val Phe Val Phe Pro Gly Gly Pro 
            420                 425                 430         


Gly Gly Leu Gly Ser Lys Pro Ser Gln Val Leu Gln Pro Leu Trp Ala 
        435                 440                 445             


Ala Ser His Thr Pro Asp Phe Phe Gly Ser Ala Leu Arg Gly Gly Arg 
    450                 455                 460                 


Asp Leu Asp Gly Asn Gly Tyr Pro Asp Leu Ile Val Gly Ser Phe Gly 
465                 470                 475                 480 


Val Asp Lys Ala Val Val Tyr Arg Gly Arg Pro Ile Val Ser Ala Ser 
                485                 490                 495     


Ala Ser Leu Thr Ile Phe Pro Ala Met Phe Asn Pro Glu Glu Arg Ser 
            500                 505                 510         


Cys Ser Leu Glu Gly Asn Pro Val Ala Cys Ile Asn Leu Ser Phe Cys 
        515                 520                 525             


Leu Asn Ala Ser Gly Lys His Val Ala Asp Ser Ile Gly Phe Thr Val 
    530                 535                 540                 


Glu Leu Gln Leu Asp Trp Gln Lys Gln Lys Gly Gly Val Arg Arg Ala 
545                 550                 555                 560 


Leu Phe Leu Ala Ser Arg Gln Ala Thr Leu Thr Gln Thr Leu Leu Ile 
                565                 570                 575     


Gln Asn Gly Ala Arg Glu Asp Cys Arg Glu Met Lys Ile Tyr Leu Arg 
            580                 585                 590         


Asn Glu Ser Glu Phe Arg Asp Lys Leu Ser Pro Ile His Ile Ala Leu 
        595                 600                 605             


Asn Phe Ser Leu Asp Pro Gln Ala Pro Val Asp Ser His Gly Leu Arg 
    610                 615                 620                 


Pro Ala Leu His Tyr Gln Ser Lys Ser Arg Ile Glu Asp Lys Ala Gln 
625                 630                 635                 640 


Ile Leu Leu Asp Cys Gly Glu Asp Asn Ile Cys Val Pro Asp Leu Gln 
                645                 650                 655     


Leu Glu Val Phe Gly Glu Gln Asn His Val Tyr Leu Gly Asp Lys Asn 
            660                 665                 670         


Ala Leu Asn Leu Thr Phe His Ala Gln Asn Val Gly Glu Gly Gly Ala 
        675                 680                 685             


Tyr Glu Ala Glu Leu Arg Val Thr Ala Pro Pro Glu Ala Glu Tyr Ser 
    690                 695                 700                 


Gly Leu Val Arg His Pro Gly Asn Phe Ser Ser Leu Ser Cys Asp Tyr 
705                 710                 715                 720 


Phe Ala Val Asn Gln Ser Arg Leu Leu Val Cys Asp Leu Gly Asn Pro 
                725                 730                 735     


Met Lys Ala Gly Ala Ser Leu Trp Gly Gly Leu Arg Phe Thr Val Pro 
            740                 745                 750         


His Leu Arg Asp Thr Lys Lys Thr Ile Gln Phe Asp Phe Gln Ile Leu 
        755                 760                 765             


Ser Lys Asn Leu Asn Asn Ser Gln Ser Asp Val Val Ser Phe Arg Leu 
    770                 775                 780                 


Ser Val Glu Ala Gln Ala Gln Val Thr Leu Asn Gly Val Ser Lys Pro 
785                 790                 795                 800 


Glu Ala Val Leu Phe Pro Val Ser Asp Trp His Pro Arg Asp Gln Pro 
                805                 810                 815     


Gln Lys Glu Glu Asp Leu Gly Pro Ala Val His His Val Tyr Glu Leu 
            820                 825                 830         


Ile Asn Gln Gly Pro Ser Ser Ile Ser Gln Gly Val Leu Glu Leu Ser 
        835                 840                 845             


Cys Pro Gln Ala Leu Glu Gly Gln Gln Leu Leu Tyr Val Thr Arg Val 
    850                 855                 860                 


Thr Gly Leu Asn Cys Thr Thr Asn His Pro Ile Asn Pro Lys Gly Leu 
865                 870                 875                 880 


Glu Leu Asp Pro Glu Gly Ser Leu His His Gln Gln Lys Arg Glu Ala 
                885                 890                 895     


Pro Ser Arg Ser Ser Ala Ser Ser Gly Pro Gln Ile Leu Lys Cys Pro 
            900                 905                 910         


Glu Ala Glu Cys Phe Arg Leu Arg Cys Glu Leu Gly Pro Leu His Gln 
        915                 920                 925             


Gln Glu Ser Gln Ser Leu Gln Leu His Phe Arg Val Trp Ala Lys Thr 
    930                 935                 940                 


Phe Leu Gln Arg Glu His Gln Pro Phe Ser Leu Gln Cys Glu Ala Val 
945                 950                 955                 960 


Tyr Lys Ala Leu Lys Met Pro Tyr Arg Ile Leu Pro Arg Gln Leu Pro 
                965                 970                 975     


Gln Lys Glu Arg Gln Val Ala Thr Ala Val Gln Trp Thr Lys Ala Glu 
            980                 985                 990         


Gly Ser Tyr Gly Val Pro Leu Trp  Ile Ile Ile Leu Ala  Ile Leu Phe 
        995                 1000                 1005             


Gly Leu  Leu Leu Leu Gly Leu  Leu Ile Tyr Ile Leu  Tyr Lys Leu 
    1010                 1015                 1020             


Gly Phe  Phe Lys Arg Ser Leu  Pro Tyr Gly Thr Ala  Met Glu Lys 
    1025                 1030                 1035             


Ala Gln  Leu Lys Pro Pro Ala  Thr Ser Asp Ala 
    1040                 1045                 


<210>  24
<211>  4267
<212>  DNA
<213>  homo sapiens

<400>  24
attcgcctct gggaggttta ggaagcggct ccgggtcggt ggccccagga cagggaagag       60

cgggcgctat ggggagccgg acgccagagt cccctctcca cgccgtgcag ctgcgctggg      120

gcccccggcg ccgacccccg ctgctgccgc tgctgttgct gctgctgccg ccgccaccca      180

gggtcggggg cttcaactta gacgcggagg ccccagcagt actctcgggg cccccgggct      240

ccttcttcgg attctcagtg gagttttacc ggccgggaac agacggggtc agtgtgctgg      300

tgggagcacc caaggctaat accagccagc caggagtgct gcagggtggt gctgtctacc      360

tctgtccttg gggtgccagc cccacacagt gcacccccat tgaatttgac agcaaaggct      420

ctcggctcct ggagtcctca ctgtccagct cagagggaga ggagcctgtg gagtacaagt      480

ccttgcagtg gttcggggca acagttcgag cccatggctc ctccatcttg gcatgcgctc      540

cactgtacag ctggcgcaca gagaaggagc cactgagcga ccccgtgggc acctgctacc      600

tctccacaga taacttcacc cgaattctgg agtatgcacc ctgccgctca gatttcagct      660

gggcagcagg acagggttac tgccaaggag gcttcagtgc cgagttcacc aagactggcc      720

gtgtggtttt aggtggacca ggaagctatt tctggcaagg ccagatcctg tctgccactc      780

aggagcagat tgcagaatct tattaccccg agtacctgat caacctggtt caggggcagc      840

tgcagactcg ccaggccagt tccatctatg atgacagcta cctaggatac tctgtggctg      900

ttggtgaatt cagtggtgat gacacagaag actttgttgc tggtgtgccc aaagggaacc      960

tcacttacgg ctatgtcacc atccttaatg gctcagacat tcgatccctc tacaacttct     1020

caggggaaca gatggcctcc tactttggct atgcagtggc cgccacagac gtcaatgggg     1080

acgggctgga tgacttgctg gtgggggcac ccctgctcat ggatcggacc cctgacgggc     1140

ggcctcagga ggtgggcagg gtctacgtct acctgcagca cccagccggc atagagccca     1200

cgcccaccct taccctcact ggccatgatg agtttggccg atttggcagc tccttgaccc     1260

ccctggggga cctggaccag gatggctaca atgatgtggc catcggggct ccctttggtg     1320

gggagaccca gcagggagta gtgtttgtat ttcctggggg cccaggaggg ctgggctcta     1380

agccttccca ggttctgcag cccctgtggg cagccagcca caccccagac ttctttggct     1440

ctgcccttcg aggaggccga gacctggatg gcaatggata tcctgatctg attgtggggt     1500

cctttggtgt ggacaaggct gtggtataca ggggccgccc catcgtgtcc gctagtgcct     1560

ccctcaccat cttccccgcc atgttcaacc cagaggagcg gagctgcagc ttagagggga     1620

accctgtggc ctgcatcaac cttagcttct gcctcaatgc ttctggaaaa cacgttgctg     1680

actccattgg tttcacagtg gaacttcagc tggactggca gaagcagaag ggaggggtac     1740

ggcgggcact gttcctggcc tccaggcagg caaccctgac ccagaccctg ctcatccaga     1800

atggggctcg agaggattgc agagagatga agatctacct caggaacgag tcagaatttc     1860

gagacaaact ctcgccgatt cacatcgctc tcaacttctc cttggacccc caagccccag     1920

tggacagcca cggcctcagg ccagccctac attatcagag caagagccgg atagaggaca     1980

aggctcagat cttgctggac tgtggagaag acaacatctg tgtgcctgac ctgcagctgg     2040

aagtgtttgg ggagcagaac catgtgtacc tgggtgacaa gaatgccctg aacctcactt     2100

tccatgccca gaatgtgggt gagggtggcg cctatgaggc tgagcttcgg gtcaccgccc     2160

ctccagaggc tgagtactca ggactcgtca gacacccagg gaacttctcc agcctgagct     2220

gtgactactt tgccgtgaac cagagccgcc tgctggtgtg tgacctgggc aaccccatga     2280

aggcaggagc cagtctgtgg ggtggccttc ggtttacagt ccctcatctc cgggacacta     2340

agaaaaccat ccagtttgac ttccagatcc tcagcaagaa tctcaacaac tcgcaaagcg     2400

acgtggtttc ctttcggctc tccgtggagg ctcaggccca ggtcaccctg aacggtgtct     2460

ccaagcctga ggcagtgcta ttcccagtaa gcgactggca tccccgagac cagcctcaga     2520

aggaggagga cctgggacct gctgtccacc atgtctatga gctcatcaac caaggcccca     2580

gctccattag ccagggtgtg ctggaactca gctgtcccca ggctctggaa ggtcagcagc     2640

tcctatatgt gaccagagtt acgggactca actgcaccac caatcacccc attaacccaa     2700

agggcctgga gttggatccc gagggttccc tgcaccacca gcaaaaacgg gaagctccaa     2760

gccgcagctc tgcttcctcg ggacctcaga tcctgaaatg cccggaggct gagtgtttca     2820

ggctgcgctg tgagctcggg cccctgcacc aacaagagag ccaaagtctg cagttgcatt     2880

tccgagtctg ggccaagact ttcttgcagc gggagcacca gccatttagc ctgcagtgtg     2940

aggctgtgta caaagccctg aagatgccct accgaatcct gcctcggcag ctgccccaaa     3000

aagagcgtca ggtggccaca gctgtgcaat ggaccaaggc agaaggcagc tatggcgtcc     3060

cactgtggat catcatccta gccatcctgt ttggcctcct gctcctaggt ctactcatct     3120

acatcctcta caagcttgga ttcttcaaac gctccctccc atatggcacc gccatggaaa     3180

aagctcagct caagcctcca gccacctctg atgcctgagt cctcccaatt tcagactccc     3240

attcctgaag aaccagtccc cccaccctca ttctactgaa aaggaggggt ctgggtactt     3300

cttgaaggtg ctgacggcca gggagaagct cctctcccca gcccagagac atacttgaag     3360

ggccagagcc aggggggtga ggagctgggg atccctcccc cccatgcact gtgaaggacc     3420

cttgtttaca cataccctct tcatggatgg gggaactcag atccagggac agaggcccca     3480

gcctccctga agcctttgca ttttggagag tttcctgaaa caacttggaa agataactag     3540

gaaatccatt cacagttctt tgggccagac atgccacaag gacttcctgt ccagctccaa     3600

cctgcaaaga tctgtcctca gccttgccag agatccaaaa gaagccccca gctaagaacc     3660

tggaacttgg ggagttaaga cctggcagct ctggacagcc ccaccctggt gggccaacaa     3720

agaacactaa ctatgcatgg tgccccagga ccagctcagg acagatgcca cacaaggata     3780

gatgctggcc cagggcccag agcccagctc caaggggaat cagaactcaa atggggccag     3840

atccagcctg gggtctggag ttgatctgga acccagactc agacattggc acctaatcca     3900

ggcagatcca ggactatatt tgggcctgct ccagacctga tcctggaggc ccagttcacc     3960

ctgatttagg agaagccagg aatttcccag gaccctgaag gggccatgat ggcaacagat     4020

ctggaacctc agcctggcca gacacaggcc ctccctgttc cccagagaaa ggggagccca     4080

ctgtcctggg cctgcagaat ttgggttctg cctgccagct gcactgatgc tgcccctcat     4140

ctctctgccc aacccttccc tcaccttggc accagacacc caggacttat ttaaactctg     4200

ttgcaagtgc aataaatctg acccagtgcc cccactgacc agaactagaa aaaaaaaaaa     4260

aaaaaaa                                                               4267


<210>  25
<211>  314
<212>  PRT
<213>  homo sapiens

<400>  25

Met Arg Ile Ala Val Ile Cys Phe Cys Leu Leu Gly Ile Thr Cys Ala 
1               5                   10                  15      


Ile Pro Val Lys Gln Ala Asp Ser Gly Ser Ser Glu Glu Lys Gln Leu 
            20                  25                  30          


Tyr Asn Lys Tyr Pro Asp Ala Val Ala Thr Trp Leu Asn Pro Asp Pro 
        35                  40                  45              


Ser Gln Lys Gln Asn Leu Leu Ala Pro Gln Asn Ala Val Ser Ser Glu 
    50                  55                  60                  


Glu Thr Asn Asp Phe Lys Gln Glu Thr Leu Pro Ser Lys Ser Asn Glu 
65                  70                  75                  80  


Ser His Asp His Met Asp Asp Met Asp Asp Glu Asp Asp Asp Asp His 
                85                  90                  95      


Val Asp Ser Gln Asp Ser Ile Asp Ser Asn Asp Ser Asp Asp Val Asp 
            100                 105                 110         


Asp Thr Asp Asp Ser His Gln Ser Asp Glu Ser His His Ser Asp Glu 
        115                 120                 125             


Ser Asp Glu Leu Val Thr Asp Phe Pro Thr Asp Leu Pro Ala Thr Glu 
    130                 135                 140                 


Val Phe Thr Pro Val Val Pro Thr Val Asp Thr Tyr Asp Gly Arg Gly 
145                 150                 155                 160 


Asp Ser Val Val Tyr Gly Leu Arg Ser Lys Ser Lys Lys Phe Arg Arg 
                165                 170                 175     


Pro Asp Ile Gln Tyr Pro Asp Ala Thr Asp Glu Asp Ile Thr Ser His 
            180                 185                 190         


Met Glu Ser Glu Glu Leu Asn Gly Ala Tyr Lys Ala Ile Pro Val Ala 
        195                 200                 205             


Gln Asp Leu Asn Ala Pro Ser Asp Trp Asp Ser Arg Gly Lys Asp Ser 
    210                 215                 220                 


Tyr Glu Thr Ser Gln Leu Asp Asp Gln Ser Ala Glu Thr His Ser His 
225                 230                 235                 240 


Lys Gln Ser Arg Leu Tyr Lys Arg Lys Ala Asn Asp Glu Ser Asn Glu 
                245                 250                 255     


His Ser Asp Val Ile Asp Ser Gln Glu Leu Ser Lys Val Ser Arg Glu 
            260                 265                 270         


Phe His Ser His Glu Phe His Ser His Glu Asp Met Leu Val Val Asp 
        275                 280                 285             


Pro Lys Ser Lys Glu Glu Asp Lys His Leu Lys Phe Arg Ile Ser His 
    290                 295                 300                 


Glu Leu Asp Ser Ala Ser Ser Glu Val Asn 
305                 310                 


<210>  26
<211>  1641
<212>  DNA
<213>  homo sapiens

<400>  26
ctccctgtgt tggtggagga tgtctgcagc agcatttaaa ttctgggagg gcttggttgt       60

cagcagcagc aggaggaggc agagcacagc atcgtcggga ccagactcgt ctcaggccag      120

ttgcagcctt ctcagccaaa cgccgaccaa ggaaaactca ctaccatgag aattgcagtg      180

atttgctttt gcctcctagg catcacctgt gccataccag ttaaacaggc tgattctgga      240

agttctgagg aaaagcagct ttacaacaaa tacccagatg ctgtggccac atggctaaac      300

cctgacccat ctcagaagca gaatctccta gccccacaga atgctgtgtc ctctgaagaa      360

accaatgact ttaaacaaga gacccttcca agtaagtcca acgaaagcca tgaccacatg      420

gatgatatgg atgatgaaga tgatgatgac catgtggaca gccaggactc cattgactcg      480

aacgactctg atgatgtaga tgacactgat gattctcacc agtctgatga gtctcaccat      540

tctgatgaat ctgatgaact ggtcactgat tttcccacgg acctgccagc aaccgaagtt      600

ttcactccag ttgtccccac agtagacaca tatgatggcc gaggtgatag tgtggtttat      660

ggactgaggt caaaatctaa gaagtttcgc agacctgaca tccagtaccc tgatgctaca      720

gacgaggaca tcacctcaca catggaaagc gaggagttga atggtgcata caaggccatc      780

cccgttgccc aggacctgaa cgcgccttct gattgggaca gccgtgggaa ggacagttat      840

gaaacgagtc agctggatga ccagagtgct gaaacccaca gccacaagca gtccagatta      900

tataagcgga aagccaatga tgagagcaat gagcattccg atgtgattga tagtcaggaa      960

ctttccaaag tcagccgtga attccacagc catgaatttc acagccatga agatatgctg     1020

gttgtagacc ccaaaagtaa ggaagaagat aaacacctga aatttcgtat ttctcatgaa     1080

ttagatagtg catcttctga ggtcaattaa aaggagaaaa aatacaattt ctcactttgc     1140

atttagtcaa aagaaaaaat gctttatagc aaaatgaaag agaacatgaa atgcttcttt     1200

ctcagtttat tggttgaatg tgtatctatt tgagtctgga aataactaat gtgtttgata     1260

attagtttag tttgtggctt catggaaact ccctgtaaac taaaagcttc agggttatgt     1320

ctatgttcat tctatagaag aaatgcaaac tatcactgta ttttaatatt tgttattctc     1380

tcatgaatag aaatttatgt agaagcaaac aaaatacttt tacccactta aaaagagaat     1440

ataacatttt atgtcactat aatcttttgt tttttaagtt agtgtatatt ttgttgtgat     1500

tatctttttg tggtgtgaat aaatctttta tcttgaatgt aataagaatt tggtggtgtc     1560

aattgcttat ttgttttccc acggttgtcc agcaattaat aaaacataac cttttttact     1620

gcctaaaaaa aaaaaaaaaa a                                               1641


