                         SEQUENCE LISTING

<110>  Hopital Ste-Justine
       Moreau, Alain
       Elbakry, Mohamed
       Akoume Ndong, Marie-Yvonne
 
<120>  NEW MARKERS FOR SEVERE PROGRESSION OF IDIOPATHIC SCOLIOSIS AND 
       USES THEREOF TO STRATIFY SCOLIOTIC PATIENTS AND PREDICT THE RISK 
       OF DEVELOPING SCOLIOSIS

<130>  765/14033_124

<140>  N/A
<141>  2014-06-17

<150>  US 61/835,698
<151>  2013-06-17

<160>  39    

<170>  PatentIn version 3.5

<210>  1
<211>  18
<212>  DNA
<213>  Artificial sequence

<220>
<223>  Synthetic Construct

<400>  1
ggaaatcgtg cgtgacat                                                     18


<210>  2
<211>  23
<212>  DNA
<213>  Artificial sequence

<220>
<223>  Synthetic Construct

<400>  2
tcatgatgga gttgaaggta gtt                                               23


<210>  3
<211>  19
<212>  DNA
<213>  Artificial sequence

<220>
<223>  Synthetic Construct

<400>  3
ggccggactt ttgctaact                                                    19


<210>  4
<211>  21
<212>  DNA
<213>  Artificial sequence

<220>
<223>  Synthetic Construct

<400>  4
tgtgctatac ggctcatcaa a                                                 21


<210>  5
<211>  20
<212>  DNA
<213>  Artificial sequence

<220>
<223>  Synthetic Construct

<400>  5
agcatcggat ttgagacctg                                                   20


<210>  6
<211>  20
<212>  DNA
<213>  Artificial sequence

<220>
<223>  Synthetic Construct

<400>  6
tgagtccact tggctttctg                                                   20


<210>  7
<211>  19
<212>  DNA
<213>  Artificial sequence

<220>
<223>  Synthetic Construct

<400>  7
atgtgtcaga cctgccttg                                                    19


<210>  8
<211>  21
<212>  DNA
<213>  Artificial sequence

<220>
<223>  Synthetic Construct

<400>  8
ttgtcccgac tttctacctt g                                                 21


<210>  9
<211>  22
<212>  DNA
<213>  Artificial sequence

<220>
<223>  Synthetic Construct

<400>  9
ggaaagtcca tcctgtatgt gg                                                22


<210>  10
<211>  20
<212>  DNA
<213>  Artificial sequence

<220>
<223>  Synthetic Construct

<400>  10
gagtttccag atgagcaggg                                                   20


<210>  11
<211>  22
<212>  DNA
<213>  Artificial sequence

<220>
<223>  Synthetic Construct

<400>  11
gtccccacag tagacacata tg                                                22


<210>  12
<211>  20
<212>  DNA
<213>  Artificial sequence

<220>
<223>  Synthetic Construct

<400>  12
tcaactcctc gctttccatg                                                   20


<210>  13
<211>  25
<212>  DNA
<213>  Artificial sequence

<220>
<223>  Synthetic Construct

<400>  13
gacatttgga tgaactttag tcacc                                             25


<210>  14
<211>  21
<212>  DNA
<213>  Artificial sequence

<220>
<223>  Synthetic Construct

<400>  14
ggcaatggaa ttcacgactt g                                                 21


<210>  15
<211>  22
<212>  DNA
<213>  Artificial sequence

<220>
<223>  Synthetic Construct

<400>  15
ggatgagact tcagcactca ag                                                22


<210>  16
<211>  24
<212>  DNA
<213>  Artificial sequence

<220>
<223>  Synthetic Construct

<400>  16
ggtgaaataa cgtttgggtc tttg                                              24


<210>  17
<211>  22
<212>  DNA
<213>  Artificial sequence

<220>
<223>  Synthetic Construct

<400>  17
ggaaagtcca tcctgtatgt gg                                                22


<210>  18
<211>  20
<212>  DNA
<213>  Artificial sequence

<220>
<223>  Synthetic Construct

<400>  18
gagtttccag atgagcaggg                                                   20


<210>  19
<211>  20
<212>  DNA
<213>  Artificial sequence

<220>
<223>  Synthetic Construct

<400>  19
cttgcactcc tggctatctg                                                   20


<210>  20
<211>  19
<212>  DNA
<213>  Artificial sequence

<220>
<223>  Synthetic Construct

<400>  20
tgcgtggaga taggctttc                                                    19


<210>  21
<211>  22
<212>  DNA
<213>  Artificial sequence

<220>
<223>  Synthetic Construct

<400>  21
gattgggttg cttaaagtcc tg                                                22


<210>  22
<211>  20
<212>  DNA
<213>  Artificial sequence

<220>
<223>  Synthetic Construct

<400>  22
ggtaggtgac tgctcttgtg                                                   20


<210>  23
<211>  21
<212>  DNA
<213>  Artificial sequence

<220>
<223>  Synthetic Construct

<400>  23
cagattacag tgcaggtgga g                                                 21


<210>  24
<211>  21
<212>  DNA
<213>  Artificial sequence

<220>
<223>  Synthetic Construct

<400>  24
gctggcagtt tctacttcaa c                                                 21


<210>  25
<211>  25
<212>  RNA
<213>  Artificial sequence

<220>
<223>  Synthetic Construct

<400>  25
ccacagccac aagcagucca gauua                                             25


<210>  26
<211>  22
<212>  RNA
<213>  Artificial sequence

<220>
<223>  Synthetic Construct

<400>  26
ccuccacauc gggauugaua uu                                                22


<210>  27
<211>  4998
<212>  DNA
<213>  Homosapiens

<400>  27
ctcccttggc cggcggcgct tgttgttcgg cggcggcggt cgcagctcgg gtccccctcg       60

ggcgcccccg ccgccgtccg cgcgcggcca tggagctgga ggtaccggac gaggcggaga      120

gcgctgaggc gggggccgtg ccctcggagg cggcgtgggc ggcagagagc ggggcggcgg      180

caggtttggc tcagaagaag gcggccccaa cagaggttct gtccatgacg gcacagccgg      240

gccctggcca tgggaagaag ttgggccatc gaggtgtgga cgcatccggc gaaaccacct      300

acaagaagac cacctcctcc accctgaagg gtgccatcca gctgggcatc ggctacaccg      360

tgggccacct gagctccaag cccgaacgcg acgtgctcat gcaggacttc tacgtggtgg      420

agagcatctt cttccccagc gaaggcagca acctcacccc cgcccaccac ttccaggact      480

tccgcttcaa gacctatgca cctgtcgcct tccgctactt ccgggagctc tttgggatcc      540

ggccagatga ttacttgtac tccctgtgca atgagccgct gatcgagctg tccaacccgg      600

gcgccagtgg ctccctcttc tacgtcacca gcgacgacga gttcatcatc aagaccgtca      660

tgcacaagga ggccgagttc ctgcagaagc tgctccctgg ctactacatg aacctcaacc      720

agaacccgcg gacgctgctg cccaagttct atgggctgta ctgcgtgcag tcggggggca      780

agaacatccg cgtcgtggtc atgaacaaca tcctgccccg cgtggtcaag atgcacctca      840

agttcgacct caagggctcc acctacaagc ggcgcgccag caagaaggag aaggagaaga      900

gcttccccac ctacaaggac ctggacttca tgcaggacat gcccgagggg ctcctgctgg      960

acgccgacac cttcagcgcc ctggtcaaga cgctgcagcg ggactgcctg gtcctggaaa     1020

gtttcaagat catggactac agcctgctgc tgggcgtgca caacatcgac cagcacgagc     1080

gcgagcggca ggcgcagggc gcccagagca cctcagatga gaagcggcct gtgggccaga     1140

aggcgctcta ctccacggcc atggagtcca tccagggtgg cgccgcgcgc ggggaggcca     1200

tcgaatcgga tgacacgatg ggcgggatcc ccgctgtgaa cggccgcggg gagcggctgc     1260

tgctgcacat tggcatcatc gacatcctgc agtcctacag gttcatcaag aaactggagc     1320

acacctggaa ggccctcgtc cacgatgggg acacggtgtc cgtccaccgc cccagcttct     1380

atgccgagcg ctttttcaag ttcatgagca acacggtctt tcggaagaac tcctccctga     1440

agtcctcgcc ctccaagaag gggcgcggcg gagccttgct agctgtgaaa ccgctggggc     1500

ccaccgctgc cttctcggcc agccagatcc ctagcgagcg ggaggaggcc cagtacgacc     1560

tgcggggggc ccgcagctac cccacgctgg aggacgaagg ccggcccgac ctcctgccct     1620

gcacgccacc ttctttcgaa gaagccacta cagcctccat tgccacgact ctgtcatcca     1680

catccctctc cattcctgag cggtccccct cggagacgtc ggagcagccg cggtacaggc     1740

ggcgcacaca gtcgtctgga caggatggca ggccgcagga ggagccaccc gcggaagagg     1800

atctgcagca gattacagtg caggtggagc ctgcgtgcag cgtggagatt gtggtcccca     1860

aagaggagga cgcaggggtg gaggcttccc cggccggtgc ctctgctgct gttgaagtag     1920

aaactgccag ccaggcctca gacgaggagg gcgcacctgc cagccaggcc tcggacgagg     1980

aggacgcgcc cgccaccgac atctactttt aatttctatg cagcccccga cccagagccg     2040

agctccactt ctgctccggc tgcccccgaa ggcgctgccc accccgctga ggcccagagc     2100

tcgggagatg cccgcctcgc cgccccaccg gacctcgtcc tccccctgca cggatgccga     2160

cggccgggcc cctccccgac aagcctccca gggccccggc accccggtcg gcagcctgcc     2220

cctgtgagac ccaccctccc gagcggccaa tcgcatttga gtccttattt ggcacagaga     2280

cggaagcacg tgtgtgccgt tttaggaaaa gaacaaaaaa gacacaaaca aaccaaccag     2340

agggagaaga gcccctgccc actgcactct ttggttctct gctgtgcctg cctgtgtcct     2400

gaggaagaag ccaggctgtt cgcggtggcc tctggggacc tgagccccgg gggccccatc     2460

ggcctgcaga ggggacggct ggggtcccga gcaactctgc ctccatccac gtgggaagcg     2520

gaccctcctg ccctcagctt gggtttgggg gcctcagtgc aggacatctg gcctgaacat     2580

cgactgtggg gacagccctc gccctgccaa gcactgcggc cactcagcag ctatgttccc     2640

gccgcagtgg ggccctgacg cccacctccc aggtgcccct cgagcaaaaa cctctggcgc     2700

ctccaatcca gacccaccac agctggaggg ccaggcctcc tcttccccag gctgccaccc     2760

acgctggcgg agctcagggc tggggacttg tccttctctt ccaacgtagg ccactcagca     2820

actggcatgg agggcccagg caacggagac gttttctcca tggcaggaca gagcgggagg     2880

ccgggccttg ggccacagga gaccagctca gggcggaagg tcaggctccc cgccccctcc     2940

acgtggagac atggcctagg gggccaggcc cggctccaca ggagtctcct tcaggactgg     3000

tgtggatgtc cgccgcctct ttcttgttta agtgatgtga tgtctccgag gaggggagag     3060

aagactttgt ttccgactca tcaccctcca agagggcagc gctcccagtg gtgggactca     3120

gcccagactg ccctggggca gcttcctggg cccgctgcgc tcagagggtg ctggttggag     3180

gccagagctc ggcagagtca cccaccctgc ccttccccag gacccctgag aggggcttat     3240

tggtgatggc tgtgggaatc ccccacttcc aagatgtgcc caggatgtga ggagctggag     3300

tggaagctgc acctttggga agaattcctc tccagacctg gcagagcctg gtgtggggtc     3360

tgagacggcc ggagaacctc ccaggcaggg ctctgtgttt tgtctgttac aacctccgta     3420

tgacgccacg ccacccgctg ttcacgtccc gtcggcctcc tgcacagccc acacgctgcg     3480

cccggaaggc ccctgctgtg gagaagccgg acccatcccc gaggtcccca gcgaggacac     3540

acactccacg agagcagccc ctccactctg cccaggagag gggccgaccc tcctcgggaa     3600

ccggccagcc gcgtggctcc cagcatccat caggacaagc ccacgtgggg tcctccctgc     3660

gtgctcagag ggtctgtcca gccctgggaa gcgaccttgg cctcagttca cagcctggtg     3720

ctcatctgct ggcaccgggc atccacccat cagcccccgc cctgtccctc cgaaggacac     3780

ccagcaggca ccccccgggg aggcaggggc agaggtcaga aggggtgtct gggacctgga     3840

tggccagcag ggacaggggc attgtcatct caaaggccca acccccagag gccacaccag     3900

tcctcccagg gagtcctcga gtcgccctgc ccagagccct ggcaccagag acgccaagag     3960

cctgtggggt gactcggagc agcaggtgtg gccccgggcg ggcggcaccg cgtccagggc     4020

agcctccctc cgctgagtga cacgggacac cagtgcccgg ccgacgcgcc tttgcaggag     4080

aaatgtgcaa acctctgtgg ataccatttc atttccattc ttgtgttgtc tccaaggccc     4140

ttttggagat atacttggtg ttggttgtgt tttttggttc cttttcagag aactgtaaac     4200

cgaggctgac gtgctccact gactgtgccg aggggcgggg gcaggaggac ggcaagacct     4260

atttataata tttagcgaac tcggtctccc tcagatcccc cgcgagggag gctgctggac     4320

ccaccccgct gtcccccatg atagaagtct gtaaatacct tggtgaccaa tgcccacttc     4380

ccctcctggg tcacctctga tggctgctgt ccactgagaa cgtgggcagt gtccaaattc     4440

ctgtactgta aagactaaaa ggcgtttgct ctgagactga caaggcggaa acttccatgt     4500

gtctcctgcc aggctctgtc cccctacgcc atcccgacac gtccccgttc ccccgaaacc     4560

tggctcagtg caatactccc attgccatgg ggtccttcac catggtactg tctccacagc     4620

cctcagtccc caccccagga gaggcgcctg ccacctcctc ctcatctccg gtggttcaat     4680

cgctccgcct gtccccaacc cagtcccatt tttatggcca aactgattct gaaacaaaat     4740

gaaactgcaa acctcgtgtg tcttaactcc ccccagggat gccactccat tcctccgccc     4800

cgtggtctgg tgcgtgacaa tccaaagcgc cgagacgagg gtgctgtgtc cctcaaaccc     4860

agagtggtgg gcgcctctga aaccatacag ccactcctgg ccccaaacac tggtttgcat     4920

cccaggttcc tcgcccacct acccccgcca caccccgtct ttttagagat ctctctaata     4980

aatcgggtaa taagcatc                                                   4998


<210>  28
<211>  668
<212>  PRT
<213>  homo sapiens

<400>  28

Met Glu Leu Glu Val Pro Asp Glu Ala Glu Ser Ala Glu Ala Gly Ala 
1               5                   10                  15      


Val Pro Ser Glu Ala Ala Trp Ala Ala Glu Ser Gly Ala Ala Ala Gly 
            20                  25                  30          


Leu Ala Gln Lys Lys Ala Ala Pro Thr Glu Val Leu Ser Met Thr Ala 
        35                  40                  45              


Gln Pro Gly Pro Gly His Gly Lys Lys Leu Gly His Arg Gly Val Asp 
    50                  55                  60                  


Ala Ser Gly Glu Thr Thr Tyr Lys Lys Thr Thr Ser Ser Thr Leu Lys 
65                  70                  75                  80  


Gly Ala Ile Gln Leu Gly Ile Gly Tyr Thr Val Gly His Leu Ser Ser 
                85                  90                  95      


Lys Pro Glu Arg Asp Val Leu Met Gln Asp Phe Tyr Val Val Glu Ser 
            100                 105                 110         


Ile Phe Phe Pro Ser Glu Gly Ser Asn Leu Thr Pro Ala His His Phe 
        115                 120                 125             


Gln Asp Phe Arg Phe Lys Thr Tyr Ala Pro Val Ala Phe Arg Tyr Phe 
    130                 135                 140                 


Arg Glu Leu Phe Gly Ile Arg Pro Asp Asp Tyr Leu Tyr Ser Leu Cys 
145                 150                 155                 160 


Asn Glu Pro Leu Ile Glu Leu Ser Asn Pro Gly Ala Ser Gly Ser Leu 
                165                 170                 175     


Phe Tyr Val Thr Ser Asp Asp Glu Phe Ile Ile Lys Thr Val Met His 
            180                 185                 190         


Lys Glu Ala Glu Phe Leu Gln Lys Leu Leu Pro Gly Tyr Tyr Met Asn 
        195                 200                 205             


Leu Asn Gln Asn Pro Arg Thr Leu Leu Pro Lys Phe Tyr Gly Leu Tyr 
    210                 215                 220                 


Cys Val Gln Ser Gly Gly Lys Asn Ile Arg Val Val Val Met Asn Asn 
225                 230                 235                 240 


Ile Leu Pro Arg Val Val Lys Met His Leu Lys Phe Asp Leu Lys Gly 
                245                 250                 255     


Ser Thr Tyr Lys Arg Arg Ala Ser Lys Lys Glu Lys Glu Lys Ser Phe 
            260                 265                 270         


Pro Thr Tyr Lys Asp Leu Asp Phe Met Gln Asp Met Pro Glu Gly Leu 
        275                 280                 285             


Leu Leu Asp Ala Asp Thr Phe Ser Ala Leu Val Lys Thr Leu Gln Arg 
    290                 295                 300                 


Asp Cys Leu Val Leu Glu Ser Phe Lys Ile Met Asp Tyr Ser Leu Leu 
305                 310                 315                 320 


Leu Gly Val His Asn Ile Asp Gln His Glu Arg Glu Arg Gln Ala Gln 
                325                 330                 335     


Gly Ala Gln Ser Thr Ser Asp Glu Lys Arg Pro Val Gly Gln Lys Ala 
            340                 345                 350         


Leu Tyr Ser Thr Ala Met Glu Ser Ile Gln Gly Gly Ala Ala Arg Gly 
        355                 360                 365             


Glu Ala Ile Glu Ser Asp Asp Thr Met Gly Gly Ile Pro Ala Val Asn 
    370                 375                 380                 


Gly Arg Gly Glu Arg Leu Leu Leu His Ile Gly Ile Ile Asp Ile Leu 
385                 390                 395                 400 


Gln Ser Tyr Arg Phe Ile Lys Lys Leu Glu His Thr Trp Lys Ala Leu 
                405                 410                 415     


Val His Asp Gly Asp Thr Val Ser Val His Arg Pro Ser Phe Tyr Ala 
            420                 425                 430         


Glu Arg Phe Phe Lys Phe Met Ser Asn Thr Val Phe Arg Lys Asn Ser 
        435                 440                 445             


Ser Leu Lys Ser Ser Pro Ser Lys Lys Gly Arg Gly Gly Ala Leu Leu 
    450                 455                 460                 


Ala Val Lys Pro Leu Gly Pro Thr Ala Ala Phe Ser Ala Ser Gln Ile 
465                 470                 475                 480 


Pro Ser Glu Arg Glu Glu Ala Gln Tyr Asp Leu Arg Gly Ala Arg Ser 
                485                 490                 495     


Tyr Pro Thr Leu Glu Asp Glu Gly Arg Pro Asp Leu Leu Pro Cys Thr 
            500                 505                 510         


Pro Pro Ser Phe Glu Glu Ala Thr Thr Ala Ser Ile Ala Thr Thr Leu 
        515                 520                 525             


Ser Ser Thr Ser Leu Ser Ile Pro Glu Arg Ser Pro Ser Glu Thr Ser 
    530                 535                 540                 


Glu Gln Pro Arg Tyr Arg Arg Arg Thr Gln Ser Ser Gly Gln Asp Gly 
545                 550                 555                 560 


Arg Pro Gln Glu Glu Pro Pro Ala Glu Glu Asp Leu Gln Gln Ile Thr 
                565                 570                 575     


Val Gln Val Glu Pro Ala Cys Ser Val Glu Ile Val Val Pro Lys Glu 
            580                 585                 590         


Glu Asp Ala Gly Val Glu Ala Ser Pro Ala Gly Ala Ser Ala Ala Val 
        595                 600                 605             


Glu Val Glu Thr Ala Ser Gln Ala Ser Asp Glu Glu Gly Ala Pro Ala 
    610                 615                 620                 


Ser Gln Ala Ser Asp Glu Glu Asp Ala Pro Ala Thr Asp Ile Tyr Phe 
625                 630                 635                 640 


Pro Thr Asp Glu Arg Ser Trp Val Tyr Ser Pro Leu His Tyr Ser Ala 
                645                 650                 655     


Gln Ala Pro Pro Ala Ser Asp Gly Glu Ser Asp Thr 
            660                 665             


<210>  29
<211>  5082
<212>  DNA
<213>  homo sapiens

<400>  29
ctcccttggc cggcggcgct tgttgttcgg cggcggcggt cgcagctcgg gtccccctcg       60

ggcgcccccg ccgccgtccg cgcgcggcca tggagctgga ggtaccggac gaggcggaga      120

gcgctgaggc gggggccgtg ccctcggagg cggcgtgggc ggcagagagc ggggcggcgg      180

caggtttggc tcagaagaag gcggccccaa cagaggttct gtccatgacg gcacagccgg      240

gccctggcca tgggaagaag ttgggccatc gaggtgtgga cgcatccggc gaaaccacct      300

acaagaagac cacctcctcc accctgaagg gtgccatcca gctgggcatc ggctacaccg      360

tgggccacct gagctccaag cccgaacgcg acgtgctcat gcaggacttc tacgtggtgg      420

agagcatctt cttccccagc gaaggcagca acctcacccc cgcccaccac ttccaggact      480

tccgcttcaa gacctatgca cctgtcgcct tccgctactt ccgggagctc tttgggatcc      540

ggccagatga ttacttgtac tccctgtgca atgagccgct gatcgagctg tccaacccgg      600

gcgccagtgg ctccctcttc tacgtcacca gcgacgacga gttcatcatc aagaccgtca      660

tgcacaagga ggccgagttc ctgcagaagc tgctccctgg ctactacatg aacctcaacc      720

agaacccgcg gacgctgctg cccaagttct atgggctgta ctgcgtgcag tcggggggca      780

agaacatccg cgtcgtggtc atgaacaaca tcctgccccg cgtggtcaag atgcacctca      840

agttcgacct caagggctcc acctacaagc ggcgcgccag caagaaggag aaggagaaga      900

gcttccccac ctacaaggac ctggacttca tgcaggacat gcccgagggg ctcctgctgg      960

acgccgacac cttcagcgcc ctggtcaaga cgctgcagcg ggactgcctg gtcctggaaa     1020

gtttcaagat catggactac agcctgctgc tgggcgtgca caacatcgac cagcacgagc     1080

gcgagcggca ggcgcagggc gcccagagca cctcagatga gaagcggcct gtgggccaga     1140

aggcgctcta ctccacggcc atggagtcca tccagggtgg cgccgcgcgc ggggaggcca     1200

tcgaatcgga tgacacgatg ggcgggatcc ccgctgtgaa cggccgcggg gagcggctgc     1260

tgctgcacat tggcatcatc gacatcctgc agtcctacag gttcatcaag aaactggagc     1320

acacctggaa ggccctcgtc cacgatgggg acacggtgtc cgtccaccgc cccagcttct     1380

atgccgagcg ctttttcaag ttcatgagca acacggtctt tcggaagaac tcctccctga     1440

agtcctcgcc ctccaagaag gggcgcggcg gagccttgct agctgtgaaa ccgctggggc     1500

ccaccgctgc cttctcggcc agccagatcc ctagcgagcg ggaggaggcc cagtacgacc     1560

tgcggggggc ccgcagctac cccacgctgg aggacgaagg ccggcccgac ctcctgccct     1620

gcacgccacc ttctttcgaa gaagccacta cagcctccat tgccacgact ctgtcatcca     1680

catccctctc cattcctgag cggtccccct cggagacgtc ggagcagccg cggtacaggc     1740

ggcgcacaca gtcgtctgga caggatggca ggccgcagga ggagccaccc gcggaagagg     1800

atctgcagca gattacagtg caggtggagc ctgcgtgcag cgtggagatt gtggtcccca     1860

aagaggagga cgcaggggtg gaggcttccc cggccggtgc ctctgctgct gttgaagtag     1920

aaactgccag ccaggcctca gacgaggagg gcgcacctgc cagccaggcc tcggacgagg     1980

aggacgcgcc cgccaccgac atctactttc ccaccgatga gaggagctgg gtgtactccc     2040

cgctccacta tagcgcccag gcccccccgg cctccgacgg cgagagcgac acataatttc     2100

tatgcagccc ccgacccaga gccgagctcc acttctgctc cggctgcccc cgaaggcgct     2160

gcccaccccg ctgaggccca gagctcggga gatgcccgcc tcgccgcccc accggacctc     2220

gtcctccccc tgcacggatg ccgacggccg ggcccctccc cgacaagcct cccagggccc     2280

cggcaccccg gtcggcagcc tgcccctgtg agacccaccc tcccgagcgg ccaatcgcat     2340

ttgagtcctt atttggcaca gagacggaag cacgtgtgtg ccgttttagg aaaagaacaa     2400

aaaagacaca aacaaaccaa ccagagggag aagagcccct gcccactgca ctctttggtt     2460

ctctgctgtg cctgcctgtg tcctgaggaa gaagccaggc tgttcgcggt ggcctctggg     2520

gacctgagcc ccgggggccc catcggcctg cagaggggac ggctggggtc ccgagcaact     2580

ctgcctccat ccacgtggga agcggaccct cctgccctca gcttgggttt gggggcctca     2640

gtgcaggaca tctggcctga acatcgactg tggggacagc cctcgccctg ccaagcactg     2700

cggccactca gcagctatgt tcccgccgca gtggggccct gacgcccacc tcccaggtgc     2760

ccctcgagca aaaacctctg gcgcctccaa tccagaccca ccacagctgg agggccaggc     2820

ctcctcttcc ccaggctgcc acccacgctg gcggagctca gggctgggga cttgtccttc     2880

tcttccaacg taggccactc agcaactggc atggagggcc caggcaacgg agacgttttc     2940

tccatggcag gacagagcgg gaggccgggc cttgggccac aggagaccag ctcagggcgg     3000

aaggtcaggc tccccgcccc ctccacgtgg agacatggcc tagggggcca ggcccggctc     3060

cacaggagtc tccttcagga ctggtgtgga tgtccgccgc ctctttcttg tttaagtgat     3120

gtgatgtctc cgaggagggg agagaagact ttgtttccga ctcatcaccc tccaagaggg     3180

cagcgctccc agtggtggga ctcagcccag actgccctgg ggcagcttcc tgggcccgct     3240

gcgctcagag ggtgctggtt ggaggccaga gctcggcaga gtcacccacc ctgcccttcc     3300

ccaggacccc tgagaggggc ttattggtga tggctgtggg aatcccccac ttccaagatg     3360

tgcccaggat gtgaggagct ggagtggaag ctgcaccttt gggaagaatt cctctccaga     3420

cctggcagag cctggtgtgg ggtctgagac ggccggagaa cctcccaggc agggctctgt     3480

gttttgtctg ttacaacctc cgtatgacgc cacgccaccc gctgttcacg tcccgtcggc     3540

ctcctgcaca gcccacacgc tgcgcccgga aggcccctgc tgtggagaag ccggacccat     3600

ccccgaggtc cccagcgagg acacacactc cacgagagca gcccctccac tctgcccagg     3660

agaggggccg accctcctcg ggaaccggcc agccgcgtgg ctcccagcat ccatcaggac     3720

aagcccacgt ggggtcctcc ctgcgtgctc agagggtctg tccagccctg ggaagcgacc     3780

ttggcctcag ttcacagcct ggtgctcatc tgctggcacc gggcatccac ccatcagccc     3840

ccgccctgtc cctccgaagg acacccagca ggcacccccc ggggaggcag gggcagaggt     3900

cagaaggggt gtctgggacc tggatggcca gcagggacag gggcattgtc atctcaaagg     3960

cccaaccccc agaggccaca ccagtcctcc cagggagtcc tcgagtcgcc ctgcccagag     4020

ccctggcacc agagacgcca agagcctgtg gggtgactcg gagcagcagg tgtggccccg     4080

ggcgggcggc accgcgtcca gggcagcctc cctccgctga gtgacacggg acaccagtgc     4140

ccggccgacg cgcctttgca ggagaaatgt gcaaacctct gtggatacca tttcatttcc     4200

attcttgtgt tgtctccaag gcccttttgg agatatactt ggtgttggtt gtgttttttg     4260

gttccttttc agagaactgt aaaccgaggc tgacgtgctc cactgactgt gccgaggggc     4320

gggggcagga ggacggcaag acctatttat aatatttagc gaactcggtc tccctcagat     4380

cccccgcgag ggaggctgct ggacccaccc cgctgtcccc catgatagaa gtctgtaaat     4440

accttggtga ccaatgccca cttcccctcc tgggtcacct ctgatggctg ctgtccactg     4500

agaacgtggg cagtgtccaa attcctgtac tgtaaagact aaaaggcgtt tgctctgaga     4560

ctgacaaggc ggaaacttcc atgtgtctcc tgccaggctc tgtcccccta cgccatcccg     4620

acacgtcccc gttcccccga aacctggctc agtgcaatac tcccattgcc atggggtcct     4680

tcaccatggt actgtctcca cagccctcag tccccacccc aggagaggcg cctgccacct     4740

cctcctcatc tccggtggtt caatcgctcc gcctgtcccc aacccagtcc catttttatg     4800

gccaaactga ttctgaaaca aaatgaaact gcaaacctcg tgtgtcttaa ctccccccag     4860

ggatgccact ccattcctcc gccccgtggt ctggtgcgtg acaatccaaa gcgccgagac     4920

gagggtgctg tgtccctcaa acccagagtg gtgggcgcct ctgaaaccat acagccactc     4980

ctggccccaa acactggttt gcatcccagg ttcctcgccc acctaccccc gccacacccc     5040

gtctttttag agatctctct aataaatcgg gtaataagca tc                        5082


<210>  30
<211>  700
<212>  PRT
<213>  homo sapiens

<400>  30

Met Glu Leu Glu Val Pro Asp Glu Ala Glu Ser Ala Glu Ala Gly Ala 
1               5                   10                  15      


Val Pro Ser Glu Ala Ala Trp Ala Ala Glu Ser Gly Ala Ala Ala Gly 
            20                  25                  30          


Leu Ala Gln Lys Lys Ala Ala Pro Thr Glu Val Leu Ser Met Thr Ala 
        35                  40                  45              


Gln Pro Gly Pro Gly His Gly Lys Lys Leu Gly His Arg Gly Val Asp 
    50                  55                  60                  


Ala Ser Gly Glu Thr Thr Tyr Lys Lys Thr Thr Ser Ser Thr Leu Lys 
65                  70                  75                  80  


Gly Ala Ile Gln Leu Gly Ile Gly Tyr Thr Val Gly His Leu Ser Ser 
                85                  90                  95      


Lys Pro Glu Arg Asp Val Leu Met Gln Asp Phe Tyr Val Val Glu Ser 
            100                 105                 110         


Ile Phe Phe Pro Ser Glu Gly Ser Asn Leu Thr Pro Ala His His Phe 
        115                 120                 125             


Gln Asp Phe Arg Phe Lys Thr Tyr Ala Pro Val Ala Phe Arg Tyr Phe 
    130                 135                 140                 


Arg Glu Leu Phe Gly Ile Arg Pro Asp Asp Tyr Leu Tyr Ser Leu Cys 
145                 150                 155                 160 


Asn Glu Pro Leu Ile Glu Leu Ser Asn Pro Gly Ala Ser Gly Ser Leu 
                165                 170                 175     


Phe Tyr Val Thr Ser Asp Asp Glu Phe Ile Ile Lys Thr Val Met His 
            180                 185                 190         


Lys Glu Ala Glu Phe Leu Gln Lys Leu Leu Pro Gly Tyr Tyr Met Asn 
        195                 200                 205             


Leu Asn Gln Asn Pro Arg Thr Leu Leu Pro Lys Phe Tyr Gly Leu Tyr 
    210                 215                 220                 


Cys Val Gln Ser Gly Gly Lys Asn Ile Arg Val Val Val Met Asn Asn 
225                 230                 235                 240 


Ile Leu Pro Arg Val Val Lys Met His Leu Lys Phe Asp Leu Lys Gly 
                245                 250                 255     


Ser Thr Tyr Lys Arg Arg Ala Ser Lys Lys Glu Lys Glu Lys Ser Phe 
            260                 265                 270         


Pro Thr Tyr Lys Asp Leu Asp Phe Met Gln Asp Met Pro Glu Gly Leu 
        275                 280                 285             


Leu Leu Asp Ala Asp Thr Phe Ser Ala Leu Val Lys Thr Leu Gln Arg 
    290                 295                 300                 


Asp Cys Leu Val Leu Glu Ser Phe Lys Ile Met Asp Tyr Ser Leu Leu 
305                 310                 315                 320 


Leu Gly Val His Asn Ile Asp Gln His Glu Arg Glu Arg Gln Ala Gln 
                325                 330                 335     


Gly Ala Gln Ser Thr Ser Asp Glu Lys Arg Pro Val Gly Gln Lys Ala 
            340                 345                 350         


Leu Tyr Ser Thr Ala Met Glu Ser Ile Gln Gly Gly Ala Ala Arg Gly 
        355                 360                 365             


Glu Ala Ile Glu Ser Asp Asp Thr Met Gly Gly Ile Pro Ala Val Asn 
    370                 375                 380                 


Gly Arg Gly Glu Arg Leu Leu Leu His Ile Gly Ile Ile Asp Ile Leu 
385                 390                 395                 400 


Gln Ser Tyr Arg Phe Ile Lys Lys Leu Glu His Thr Trp Lys Ala Leu 
                405                 410                 415     


Val His Asp Gly Asp Thr Val Ser Val His Arg Pro Ser Phe Tyr Ala 
            420                 425                 430         


Glu Arg Phe Phe Lys Phe Met Ser Asn Thr Val Phe Arg Lys Asn Ser 
        435                 440                 445             


Ser Leu Lys Ser Ser Pro Ser Lys Lys Gly Arg Gly Gly Ala Leu Leu 
    450                 455                 460                 


Ala Val Lys Pro Leu Gly Pro Thr Ala Ala Phe Ser Ala Ser Gln Ile 
465                 470                 475                 480 


Pro Ser Glu Arg Glu Glu Ala Gln Tyr Asp Leu Arg Gly Ala Arg Ser 
                485                 490                 495     


Tyr Pro Thr Leu Glu Asp Glu Gly Arg Pro Asp Leu Leu Pro Cys Thr 
            500                 505                 510         


Pro Pro Ser Phe Glu Glu Ala Thr Thr Ala Ser Ile Ala Thr Thr Leu 
        515                 520                 525             


Ser Ser Thr Ser Leu Ser Ile Pro Glu Arg Ser Pro Ser Glu Thr Ser 
    530                 535                 540                 


Glu Gln Pro Arg Tyr Arg Arg Arg Thr Gln Ser Ser Gly Gln Asp Gly 
545                 550                 555                 560 


Arg Pro Gln Glu Glu Pro Pro Ala Glu Glu Asp Leu Gln Gln Ile Thr 
                565                 570                 575     


Val Gln Val Glu Pro Ala Cys Ser Val Glu Ile Val Val Pro Lys Glu 
            580                 585                 590         


Glu Asp Ala Gly Val Glu Ala Ser Pro Ala Gly Ala Ser Ala Ala Val 
        595                 600                 605             


Glu Val Glu Thr Ala Ser Gln Ala Ser Asp Glu Glu Gly Ala Pro Ala 
    610                 615                 620                 


Ser Gln Ala Ser Asp Glu Glu Asp Ala Pro Ala Thr Asp Ile Tyr Phe 
625                 630                 635                 640 


Trp Arg Leu Trp Gly Pro His Ala Pro Thr Trp Pro Trp Arg Arg Glu 
                645                 650                 655     


Gly Arg Ala Ala Cys Leu Cys Pro Tyr Pro Pro His Val Val Thr Pro 
            660                 665                 670         


Phe Pro Gly Thr Gly Leu Cys Ala Ser Trp Ser Pro Asp Gly Thr Gly 
        675                 680                 685             


Gly Leu Gly Ala Met Ser Cys Cys Val Ser Val Ser 
    690                 695                 700 


<210>  31
<211>  3471
<212>  DNA
<213>  homo sapiens

<400>  31
gcgcgccctc ccttggccgg cggcgcttgt tgttcggcgg cggcggtcgc agctcgggtc       60

cccctcgggc gcccccgccg ccgtccgcgc gcggccatgg agctggaggt accggacgag      120

gcggagagcg ctgaggcggg ggccgtgccc tcggaggcgg cgtgggcggc agagagcggg      180

gcggcggcag gtttggctca gaagaaggcg gccccaacag aggttctgtc catgacggca      240

cagccgggcc ctggccatgg gaagaagttg ggccatcgag gtgtggacgc atccggcgaa      300

accacctaca agaagaccac ctcctccacc ctgaagggtg ccatccagct gggcatcggc      360

tacaccgtgg gccacctgag ctccaagccc gaacgcgacg tgctcatgca ggacttctac      420

gtggtggaga gcatcttctt ccccagcgaa ggcagcaacc tcacccccgc ccaccacttc      480

caggacttcc gcttcaagac ctatgcacct gtcgccttcc gctacttccg ggagctcttt      540

gggatccggc cagatgatta cttgtactcc ctgtgcaatg agccgctgat cgagctgtcc      600

aacccgggcg ccagtggctc cctcttctac gtcaccagcg acgacgagtt catcatcaag      660

accgtcatgc acaaggaggc cgagttcctg cagaagctgc tccctggcta ctacatgaac      720

ctcaaccaga acccgcggac gctgctgccc aagttctatg ggctgtactg cgtgcagtcg      780

gggggcaaga acatccgcgt cgtggtcatg aacaacatcc tgccccgcgt ggtcaagatg      840

cacctcaagt tcgacctcaa gggctccacc tacaagcggc gcgccagcaa gaaggagaag      900

gagaagagct tccccaccta caaggacctg gacttcatgc aggacatgcc cgaggggctc      960

ctgctggacg ccgacacctt cagcgccctg gtcaagacgc tgcagcggga ctgcctggtc     1020

ctggaaagtt tcaagatcat ggactacagc ctgctgctgg gcgtgcacaa catcgaccag     1080

cacgagcgcg agcggcaggc gcagggcgcc cagagcacct cagatgagaa gcggcctgtg     1140

ggccagaagg cgctctactc cacggccatg gagtccatcc agggtggcgc cgcgcgcggg     1200

gaggccatcg aatcggatga cacgatgggc gggatccccg ctgtgaacgg ccgcggggag     1260

cggctgctgc tgcacattgg catcatcgac atcctgcagt cctacaggtt catcaagaaa     1320

ctggagcaca cctggaaggc cctcgtccac gatggggaca cggtgtccgt ccaccgcccc     1380

agcttctatg ccgagcgctt tttcaagttc atgagcaaca cggtctttcg gaagaactcc     1440

tccctgaagt cctcgccctc caagaagggg cgcggcggag ccttgctagc tgtgaaaccg     1500

ctggggccca ccgctgcctt ctcggccagc cagatcccta gcgagcggga ggaggcccag     1560

tacgacctgc ggggggcccg cagctacccc acgctggagg acgaaggccg gcccgacctc     1620

ctgccctgca cgccaccttc tttcgaagaa gccactacag cctccattgc cacgactctg     1680

tcatccacat ccctctccat tcctgagcgg tccccctcgg agacgtcgga gcagccgcgg     1740

tacaggcggc gcacacagtc gtctggacag gatggcaggc cgcaggagga gccacccgcg     1800

gaagaggatc tgcagcagat tacagtgcag gtggagcctg cgtgcagcgt ggagattgtg     1860

gtccccaaag aggaggacgc aggggtggag gcttccccgg ccggtgcctc tgctgctgtt     1920

gaagtagaaa ctgccagcca ggcctcagac gaggagggcg cacctgccag ccaggcctcg     1980

gacgaggagg acgcgcccgc caccgacatc tactttttca cggatgggag gtactggatt     2040

tactctcccc gccatcgccg actgcgggcc gtgacgctga gcgcctcggg gactgtaagt     2100

gaccgcagcc ggccaccctg gggagaaggg gcagtgcccc tcgggcagca gggagccgca     2160

ggtccccggc cggaagctca gtgtctgacg tcagttgttt tccagaaggg ctttgggtaa     2220

atcacggctg caattgaggt cagccacgct ggccccggac caggcgctgg gctgcatgcg     2280

tcactgggaa tgtcattcgg tcccacgtcg aaccgggcgc tccatagggc agcaccatca     2340

ccaggtgcac agctgaggcc cagggtctgc ttcggacccc ggccagaccc cagcgagccc     2400

ctctctgccc ctggacccag ccctctcgtg tcagggtgtc ttgggtggac gcttctcact     2460

cgtgcagacc tggctgcccg tggccccgct ggctgcacag gggaggttgc acaggtcagc     2520

agagtggctg cagggccggg ctctgaaccg cagggccatg gagacgggga ggagatggtc     2580

tctccacacc cacctcacag atggaggcgc tgaggcctcg gctcccctgg gagcctggga     2640

gaccacacgg tttagtcaaa atccagatcc ccaagctctc aaggaggtcc ccctgggacg     2700

ccacatgggc cccacgtagc tgtgagatcc tcagggcctg ctgttgtcat tatgaccaat     2760

aagcaagggg cccagagagc ctaagagacc tgcccagcac cgcacagcca gaacggggcg     2820

cagacccaaa gcaggagtgt cccctcgaga caaagcctcc gccgaggccg ccgtgactcc     2880

ccgcccatca gcaaacctct ccgagcacct ctgtgtgcca ggcactgtgg agtgacccca     2940

agaggtggag accacttccc cggctgctct aggcagctcc gtcccacgga gccagcggga     3000

agccagccac cgcgaagccg tgccccggag atcgtccagg agctgcccag aggggcctgc     3060

tgggaggagg agcactggag agacccagcg gccctgctgg ccaccccacc ataggcaggg     3120

agcagttcgc agaggccgcc tacggagggg ggtgcttgga ctttgaaaaa cacctgactt     3180

gaaggggcag acgtggggag ggtggtctcg gcagcaggca cagcagaagc ggaagtgtgg     3240

gggccagaag ggaggcaggg cagccattga aagcacccca aggcctgagt gctgaagagg     3300

ctgtgccctt ggttctggtc ttcctggggt cacccggttc tgggtcccag ctgctactgc     3360

cccccacttc ccctgtctgc ccagctgctg gctgagggtg tccctctctg tccccccaac     3420

tcctgcagga caaggaagcc acctgtcctg ccctttcttt tttttcattt t              3471


<210>  32
<211>  707
<212>  PRT
<213>  homo sapiens

<400>  32

Met Glu Leu Glu Val Pro Asp Glu Ala Glu Ser Ala Glu Ala Gly Ala 
1               5                   10                  15      


Val Pro Ser Glu Ala Ala Trp Ala Ala Glu Ser Gly Ala Ala Ala Gly 
            20                  25                  30          


Leu Ala Gln Lys Lys Ala Ala Pro Thr Glu Val Leu Ser Met Thr Ala 
        35                  40                  45              


Gln Pro Gly Pro Gly His Gly Lys Lys Leu Gly His Arg Gly Val Asp 
    50                  55                  60                  


Ala Ser Gly Glu Thr Thr Tyr Lys Lys Thr Thr Ser Ser Thr Leu Lys 
65                  70                  75                  80  


Gly Ala Ile Gln Leu Gly Ile Gly Tyr Thr Val Gly His Leu Ser Ser 
                85                  90                  95      


Lys Pro Glu Arg Asp Val Leu Met Gln Asp Phe Tyr Val Val Glu Ser 
            100                 105                 110         


Ile Phe Phe Pro Ser Glu Gly Ser Asn Leu Thr Pro Ala His His Phe 
        115                 120                 125             


Gln Asp Phe Arg Phe Lys Thr Tyr Ala Pro Val Ala Phe Arg Tyr Phe 
    130                 135                 140                 


Arg Glu Leu Phe Gly Ile Arg Pro Asp Asp Tyr Leu Tyr Ser Leu Cys 
145                 150                 155                 160 


Asn Glu Pro Leu Ile Glu Leu Ser Asn Pro Gly Ala Ser Gly Ser Leu 
                165                 170                 175     


Phe Tyr Val Thr Ser Asp Asp Glu Phe Ile Ile Lys Thr Val Met His 
            180                 185                 190         


Lys Glu Ala Glu Phe Leu Gln Lys Leu Leu Pro Gly Tyr Tyr Met Asn 
        195                 200                 205             


Leu Asn Gln Asn Pro Arg Thr Leu Leu Pro Lys Phe Tyr Gly Leu Tyr 
    210                 215                 220                 


Cys Val Gln Ser Gly Gly Lys Asn Ile Arg Val Val Val Met Asn Asn 
225                 230                 235                 240 


Ile Leu Pro Arg Val Val Lys Met His Leu Lys Phe Asp Leu Lys Gly 
                245                 250                 255     


Ser Thr Tyr Lys Arg Arg Ala Ser Lys Lys Glu Lys Glu Lys Ser Phe 
            260                 265                 270         


Pro Thr Tyr Lys Asp Leu Asp Phe Met Gln Asp Met Pro Glu Gly Leu 
        275                 280                 285             


Leu Leu Asp Ala Asp Thr Phe Ser Ala Leu Val Lys Thr Leu Gln Arg 
    290                 295                 300                 


Asp Cys Leu Val Leu Glu Ser Phe Lys Ile Met Asp Tyr Ser Leu Leu 
305                 310                 315                 320 


Leu Gly Val His Asn Ile Asp Gln His Glu Arg Glu Arg Gln Ala Gln 
                325                 330                 335     


Gly Ala Gln Ser Thr Ser Asp Glu Lys Arg Pro Val Gly Gln Lys Ala 
            340                 345                 350         


Leu Tyr Ser Thr Ala Met Glu Ser Ile Gln Gly Gly Ala Ala Arg Gly 
        355                 360                 365             


Glu Ala Ile Glu Ser Asp Asp Thr Met Gly Gly Ile Pro Ala Val Asn 
    370                 375                 380                 


Gly Arg Gly Glu Arg Leu Leu Leu His Ile Gly Ile Ile Asp Ile Leu 
385                 390                 395                 400 


Gln Ser Tyr Arg Phe Ile Lys Lys Leu Glu His Thr Trp Lys Ala Leu 
                405                 410                 415     


Val His Asp Gly Asp Thr Val Ser Val His Arg Pro Ser Phe Tyr Ala 
            420                 425                 430         


Glu Arg Phe Phe Lys Phe Met Ser Asn Thr Val Phe Arg Lys Asn Ser 
        435                 440                 445             


Ser Leu Lys Ser Ser Pro Ser Lys Lys Gly Arg Gly Gly Ala Leu Leu 
    450                 455                 460                 


Ala Val Lys Pro Leu Gly Pro Thr Ala Ala Phe Ser Ala Ser Gln Ile 
465                 470                 475                 480 


Pro Ser Glu Arg Glu Glu Ala Gln Tyr Asp Leu Arg Gly Ala Arg Ser 
                485                 490                 495     


Tyr Pro Thr Leu Glu Asp Glu Gly Arg Pro Asp Leu Leu Pro Cys Thr 
            500                 505                 510         


Pro Pro Ser Phe Glu Glu Ala Thr Thr Ala Ser Ile Ala Thr Thr Leu 
        515                 520                 525             


Ser Ser Thr Ser Leu Ser Ile Pro Glu Arg Ser Pro Ser Glu Thr Ser 
    530                 535                 540                 


Glu Gln Pro Arg Tyr Arg Arg Arg Thr Gln Ser Ser Gly Gln Asp Gly 
545                 550                 555                 560 


Arg Pro Gln Glu Glu Pro Pro Ala Glu Glu Asp Leu Gln Gln Ile Thr 
                565                 570                 575     


Val Gln Val Glu Pro Ala Cys Ser Val Glu Ile Val Val Pro Lys Glu 
            580                 585                 590         


Glu Asp Ala Gly Val Glu Ala Ser Pro Ala Gly Ala Ser Ala Ala Val 
        595                 600                 605             


Glu Val Glu Thr Ala Ser Gln Ala Ser Asp Glu Glu Gly Ala Pro Ala 
    610                 615                 620                 


Ser Gln Ala Ser Asp Glu Glu Asp Ala Pro Ala Thr Asp Ile Tyr Phe 
625                 630                 635                 640 


Phe Thr Asp Gly Arg Tyr Trp Ile Tyr Ser Pro Arg His Arg Arg Leu 
                645                 650                 655     


Arg Ala Val Thr Leu Ser Ala Ser Gly Thr Val Ser Asp Arg Ser Arg 
            660                 665                 670         


Pro Pro Trp Gly Glu Gly Ala Val Pro Leu Gly Gln Gln Gly Ala Ala 
        675                 680                 685             


Gly Pro Arg Pro Glu Ala Gln Cys Leu Thr Ser Val Val Phe Gln Lys 
    690                 695                 700                 


Gly Phe Gly 
705         


<210>  33
<211>  640
<212>  PRT
<213>  homo sapiens

<400>  33

Met Glu Leu Glu Val Pro Asp Glu Ala Glu Ser Ala Glu Ala Gly Ala 
1               5                   10                  15      


Val Pro Ser Glu Ala Ala Trp Ala Ala Glu Ser Gly Ala Ala Ala Gly 
            20                  25                  30          


Leu Ala Gln Lys Lys Ala Ala Pro Thr Glu Val Leu Ser Met Thr Ala 
        35                  40                  45              


Gln Pro Gly Pro Gly His Gly Lys Lys Leu Gly His Arg Gly Val Asp 
    50                  55                  60                  


Ala Ser Gly Glu Thr Thr Tyr Lys Lys Thr Thr Ser Ser Thr Leu Lys 
65                  70                  75                  80  


Gly Ala Ile Gln Leu Gly Ile Gly Tyr Thr Val Gly His Leu Ser Ser 
                85                  90                  95      


Lys Pro Glu Arg Asp Val Leu Met Gln Asp Phe Tyr Val Val Glu Ser 
            100                 105                 110         


Ile Phe Phe Pro Ser Glu Gly Ser Asn Leu Thr Pro Ala His His Phe 
        115                 120                 125             


Gln Asp Phe Arg Phe Lys Thr Tyr Ala Pro Val Ala Phe Arg Tyr Phe 
    130                 135                 140                 


Arg Glu Leu Phe Gly Ile Arg Pro Asp Asp Tyr Leu Tyr Ser Leu Cys 
145                 150                 155                 160 


Asn Glu Pro Leu Ile Glu Leu Ser Asn Pro Gly Ala Ser Gly Ser Leu 
                165                 170                 175     


Phe Tyr Val Thr Ser Asp Asp Glu Phe Ile Ile Lys Thr Val Met His 
            180                 185                 190         


Lys Glu Ala Glu Phe Leu Gln Lys Leu Leu Pro Gly Tyr Tyr Met Asn 
        195                 200                 205             


Leu Asn Gln Asn Pro Arg Thr Leu Leu Pro Lys Phe Tyr Gly Leu Tyr 
    210                 215                 220                 


Cys Val Gln Ser Gly Gly Lys Asn Ile Arg Val Val Val Met Asn Asn 
225                 230                 235                 240 


Ile Leu Pro Arg Val Val Lys Met His Leu Lys Phe Asp Leu Lys Gly 
                245                 250                 255     


Ser Thr Tyr Lys Arg Arg Ala Ser Lys Lys Glu Lys Glu Lys Ser Phe 
            260                 265                 270         


Pro Thr Tyr Lys Asp Leu Asp Phe Met Gln Asp Met Pro Glu Gly Leu 
        275                 280                 285             


Leu Leu Asp Ala Asp Thr Phe Ser Ala Leu Val Lys Thr Leu Gln Arg 
    290                 295                 300                 


Asp Cys Leu Val Leu Glu Ser Phe Lys Ile Met Asp Tyr Ser Leu Leu 
305                 310                 315                 320 


Leu Gly Val His Asn Ile Asp Gln His Glu Arg Glu Arg Gln Ala Gln 
                325                 330                 335     


Gly Ala Gln Ser Thr Ser Asp Glu Lys Arg Pro Val Gly Gln Lys Ala 
            340                 345                 350         


Leu Tyr Ser Thr Ala Met Glu Ser Ile Gln Gly Gly Ala Ala Arg Gly 
        355                 360                 365             


Glu Ala Ile Glu Ser Asp Asp Thr Met Gly Gly Ile Pro Ala Val Asn 
    370                 375                 380                 


Gly Arg Gly Glu Arg Leu Leu Leu His Ile Gly Ile Ile Asp Ile Leu 
385                 390                 395                 400 


Gln Ser Tyr Arg Phe Ile Lys Lys Leu Glu His Thr Trp Lys Ala Leu 
                405                 410                 415     


Val His Asp Gly Asp Thr Val Ser Val His Arg Pro Ser Phe Tyr Ala 
            420                 425                 430         


Glu Arg Phe Phe Lys Phe Met Ser Asn Thr Val Phe Arg Lys Asn Ser 
        435                 440                 445             


Ser Leu Lys Ser Ser Pro Ser Lys Lys Gly Arg Gly Gly Ala Leu Leu 
    450                 455                 460                 


Ala Val Lys Pro Leu Gly Pro Thr Ala Ala Phe Ser Ala Ser Gln Ile 
465                 470                 475                 480 


Pro Ser Glu Arg Glu Glu Ala Gln Tyr Asp Leu Arg Gly Ala Arg Ser 
                485                 490                 495     


Tyr Pro Thr Leu Glu Asp Glu Gly Arg Pro Asp Leu Leu Pro Cys Thr 
            500                 505                 510         


Pro Pro Ser Phe Glu Glu Ala Thr Thr Ala Ser Ile Ala Thr Thr Leu 
        515                 520                 525             


Ser Ser Thr Ser Leu Ser Ile Pro Glu Arg Ser Pro Ser Glu Thr Ser 
    530                 535                 540                 


Glu Gln Pro Arg Tyr Arg Arg Arg Thr Gln Ser Ser Gly Gln Asp Gly 
545                 550                 555                 560 


Arg Pro Gln Glu Glu Pro Pro Ala Glu Glu Asp Leu Gln Gln Ile Thr 
                565                 570                 575     


Val Gln Val Glu Pro Ala Cys Ser Val Glu Ile Val Val Pro Lys Glu 
            580                 585                 590         


Glu Asp Ala Gly Val Glu Ala Ser Pro Ala Gly Ala Ser Ala Ala Val 
        595                 600                 605             


Glu Val Glu Thr Ala Ser Gln Ala Ser Asp Glu Glu Gly Ala Pro Ala 
    610                 615                 620                 


Ser Gln Ala Ser Asp Glu Glu Asp Ala Pro Ala Thr Asp Ile Tyr Phe 
625                 630                 635                 640 


<210>  34
<211>  2724
<212>  DNA
<213>  homo sapiens

<400>  34
gcgcgccctc ccttggccgg cggcgcttgt tgttcggcgg cggcggtcgc agctcgggtc       60

cccctcgggc gcccccgccg ccgtccgcgc gcggccatgg agctggaggt accggacgag      120

gcggagagcg ctgaggcggg ggccgtgccc tcggaggcgg cgtgggcggc agagagcggg      180

gcggcggcag gtttggctca gaagaaggcg gccccaacag aggttctgtc catgacggca      240

cagccgggcc ctggccatgg gaagaagttg ggccatcgag gtgtggacgc atccggcgaa      300

accacctaca agaagaccac ctcctccacc ctgaagggtg ccatccagct gggcatcggc      360

tacaccgtgg gccacctgag ctccaagccc gaacgcgacg tgctcatgca ggacttctac      420

gtggtggaga gcatcttctt ccccagcgaa ggcagcaacc tcacccccgc ccaccacttc      480

caggacttcc gcttcaagac ctatgcacct gtcgccttcc gctacttccg ggagctcttt      540

gggatccggc cagatgatta cttgtactcc ctgtgcaatg agccgctgat cgagctgtcc      600

aacccgggcg ccagtggctc cctcttctac gtcaccagcg acgacgagtt catcatcaag      660

accgtcatgc acaaggaggc cgagttcctg cagaagctgc tccctggcta ctacatgaac      720

ctcaaccaga acccgcggac gctgctgccc aagttctatg ggctgtactg cgtgcagtcg      780

gggggcaaga acatccgcgt cgtggtcatg aacaacatcc tgccccgcgt ggtcaagatg      840

cacctcaagt tcgacctcaa gggctccacc tacaagcggc gcgccagcaa gaaggagaag      900

gagaagagct tccccaccta caaggacctg gacttcatgc aggacatgcc cgaggggctc      960

ctgctggacg ccgacacctt cagcgccctg gtcaagacgc tgcagcggga ctgcctggtc     1020

ctggaaagtt tcaagatcat ggactacagc ctgctgctgg gcgtgcacaa catcgaccag     1080

cacgagcgcg agcggcaggc gcagggcgcc cagagcacct cagatgagaa gcggcctgtg     1140

ggccagaagg cgctctactc cacggccatg gagtccatcc agggtggcgc cgcgcgcggg     1200

gaggccatcg aatcggatga cacgatgggc gggatccccg ctgtgaacgg ccgcggggag     1260

cggctgctgc tgcacattgg catcatcgac atcctgcagt cctacaggtt catcaagaaa     1320

ctggagcaca cctggaaggc cctcgtccac gatggggaca cggtgtccgt ccaccgcccc     1380

agcttctatg ccgagcgctt tttcaagttc atgagcaaca cggtctttcg gaagaactcc     1440

tccctgaagt cctcgccctc caagaagggg cgcggcggag ccttgctagc tgtgaaaccg     1500

ctggggccca ccgctgcctt ctcggccagc cagatcccta gcgagcggga ggaggcccag     1560

tacgacctgc ggggggcccg cagctacccc acgctggagg acgaaggccg gcccgacctc     1620

ctgccctgca cgccaccttc tttcgaagaa gccactacag cctccattgc cacgactctg     1680

tcatccacat ccctctccat tcctgagcgg tccccctcgg agacgtcgga gcagccgcgg     1740

tacaggccgc aggaggagcc acccgcggaa gaggatctgc agcagattac agtgcaggtg     1800

gagcctgcgt gcagcgtgga gattgtggtc cccaaagagg aggacgcagg ggtggaggct     1860

tccccggccg gtgcctctgc tgctgttgaa gtagaaactg ccagccaggc ctcagacgag     1920

gagggcgcac ctgccagcca ggcctcggac gaggaggacg cgcccgccac cgacatctac     1980

tttttcacgg atgggaggta ctggatttac tctccccgcc atcgccgact gcgggccgtg     2040

acgctgagcg cctcggggac tgtaagtgac cgcagccggc caccctgggg agaaggggca     2100

gtgcccctcg ggcagcaggg agccgcaggt ccccggccgg aagctcagtg tctgacgtca     2160

gttgttttcc agaagggctt tgggtaaatc acggctgcaa ttgaggtcag ccacgctggc     2220

cccggaccag gcgctgggct gcatgcgtca ctgggaatgt cattcggtcc cacgtcgaac     2280

cgggcgctcc atagggcagc accatcacca ggtgcacagc tgaggcccag ggtctgcttc     2340

ggaccccggc cagaccccag cgagcccctc tctgcccctg gacccagccc tctcgtgtca     2400

gggtgtcttg ggtggacgct tctcactcgt gcagacctgg ctgcccgtgg ccccgctggc     2460

tgcacagggg aggttgcaca ggtcagcaga gtggctgcag ggccgggctc tgaaccgcag     2520

ggccatggag acggggagga gatggtctct ccacacccac ctcacagatg gaggcgctga     2580

ggcctcggct cccctgggag cctgggagac cacacggttt agtcaaaatc cagatcccca     2640

agctctcaag gaggtccccc tgggacgcca catgggcccc acgtagctgt gagatcctca     2700

gggcctgctg ttgtcattat gacc                                            2724


<210>  35
<211>  696
<212>  PRT
<213>  homo sapiens

<400>  35

Met Glu Leu Glu Val Pro Asp Glu Ala Glu Ser Ala Glu Ala Gly Ala 
1               5                   10                  15      


Val Pro Ser Glu Ala Ala Trp Ala Ala Glu Ser Gly Ala Ala Ala Gly 
            20                  25                  30          


Leu Ala Gln Lys Lys Ala Ala Pro Thr Glu Val Leu Ser Met Thr Ala 
        35                  40                  45              


Gln Pro Gly Pro Gly His Gly Lys Lys Leu Gly His Arg Gly Val Asp 
    50                  55                  60                  


Ala Ser Gly Glu Thr Thr Tyr Lys Lys Thr Thr Ser Ser Thr Leu Lys 
65                  70                  75                  80  


Gly Ala Ile Gln Leu Gly Ile Gly Tyr Thr Val Gly His Leu Ser Ser 
                85                  90                  95      


Lys Pro Glu Arg Asp Val Leu Met Gln Asp Phe Tyr Val Val Glu Ser 
            100                 105                 110         


Ile Phe Phe Pro Ser Glu Gly Ser Asn Leu Thr Pro Ala His His Phe 
        115                 120                 125             


Gln Asp Phe Arg Phe Lys Thr Tyr Ala Pro Val Ala Phe Arg Tyr Phe 
    130                 135                 140                 


Arg Glu Leu Phe Gly Ile Arg Pro Asp Asp Tyr Leu Tyr Ser Leu Cys 
145                 150                 155                 160 


Asn Glu Pro Leu Ile Glu Leu Ser Asn Pro Gly Ala Ser Gly Ser Leu 
                165                 170                 175     


Phe Tyr Val Thr Ser Asp Asp Glu Phe Ile Ile Lys Thr Val Met His 
            180                 185                 190         


Lys Glu Ala Glu Phe Leu Gln Lys Leu Leu Pro Gly Tyr Tyr Met Asn 
        195                 200                 205             


Leu Asn Gln Asn Pro Arg Thr Leu Leu Pro Lys Phe Tyr Gly Leu Tyr 
    210                 215                 220                 


Cys Val Gln Ser Gly Gly Lys Asn Ile Arg Val Val Val Met Asn Asn 
225                 230                 235                 240 


Ile Leu Pro Arg Val Val Lys Met His Leu Lys Phe Asp Leu Lys Gly 
                245                 250                 255     


Ser Thr Tyr Lys Arg Arg Ala Ser Lys Lys Glu Lys Glu Lys Ser Phe 
            260                 265                 270         


Pro Thr Tyr Lys Asp Leu Asp Phe Met Gln Asp Met Pro Glu Gly Leu 
        275                 280                 285             


Leu Leu Asp Ala Asp Thr Phe Ser Ala Leu Val Lys Thr Leu Gln Arg 
    290                 295                 300                 


Asp Cys Leu Val Leu Glu Ser Phe Lys Ile Met Asp Tyr Ser Leu Leu 
305                 310                 315                 320 


Leu Gly Val His Asn Ile Asp Gln His Glu Arg Glu Arg Gln Ala Gln 
                325                 330                 335     


Gly Ala Gln Ser Thr Ser Asp Glu Lys Arg Pro Val Gly Gln Lys Ala 
            340                 345                 350         


Leu Tyr Ser Thr Ala Met Glu Ser Ile Gln Gly Gly Ala Ala Arg Gly 
        355                 360                 365             


Glu Ala Ile Glu Ser Asp Asp Thr Met Gly Gly Ile Pro Ala Val Asn 
    370                 375                 380                 


Gly Arg Gly Glu Arg Leu Leu Leu His Ile Gly Ile Ile Asp Ile Leu 
385                 390                 395                 400 


Gln Ser Tyr Arg Phe Ile Lys Lys Leu Glu His Thr Trp Lys Ala Leu 
                405                 410                 415     


Val His Asp Gly Asp Thr Val Ser Val His Arg Pro Ser Phe Tyr Ala 
            420                 425                 430         


Glu Arg Phe Phe Lys Phe Met Ser Asn Thr Val Phe Arg Lys Asn Ser 
        435                 440                 445             


Ser Leu Lys Ser Ser Pro Ser Lys Lys Gly Arg Gly Gly Ala Leu Leu 
    450                 455                 460                 


Ala Val Lys Pro Leu Gly Pro Thr Ala Ala Phe Ser Ala Ser Gln Ile 
465                 470                 475                 480 


Pro Ser Glu Arg Glu Glu Ala Gln Tyr Asp Leu Arg Gly Ala Arg Ser 
                485                 490                 495     


Tyr Pro Thr Leu Glu Asp Glu Gly Arg Pro Asp Leu Leu Pro Cys Thr 
            500                 505                 510         


Pro Pro Ser Phe Glu Glu Ala Thr Thr Ala Ser Ile Ala Thr Thr Leu 
        515                 520                 525             


Ser Ser Thr Ser Leu Ser Ile Pro Glu Arg Ser Pro Ser Glu Thr Ser 
    530                 535                 540                 


Glu Gln Pro Arg Tyr Arg Pro Gln Glu Glu Pro Pro Ala Glu Glu Asp 
545                 550                 555                 560 


Leu Gln Gln Ile Thr Val Gln Val Glu Pro Ala Cys Ser Val Glu Ile 
                565                 570                 575     


Val Val Pro Lys Glu Glu Asp Ala Gly Val Glu Ala Ser Pro Ala Gly 
            580                 585                 590         


Ala Ser Ala Ala Val Glu Val Glu Thr Ala Ser Gln Ala Ser Asp Glu 
        595                 600                 605             


Glu Gly Ala Pro Ala Ser Gln Ala Ser Asp Glu Glu Asp Ala Pro Ala 
    610                 615                 620                 


Thr Asp Ile Tyr Phe Phe Thr Asp Gly Arg Tyr Trp Ile Tyr Ser Pro 
625                 630                 635                 640 


Arg His Arg Arg Leu Arg Ala Val Thr Leu Ser Ala Ser Gly Thr Val 
                645                 650                 655     


Ser Asp Arg Ser Arg Pro Pro Trp Gly Glu Gly Ala Val Pro Leu Gly 
            660                 665                 670         


Gln Gln Gly Ala Ala Gly Pro Arg Pro Glu Ala Gln Cys Leu Thr Ser 
        675                 680                 685             


Val Val Phe Gln Lys Gly Phe Gly 
    690                 695     


<210>  36
<211>  5624
<212>  DNA
<213>  homo sapiens

<400>  36
agtcagtcgg ggagcaagag ccccgcgcgc agccggcgcg ggctcggtca tcggcgcgcc       60

gccgcccggg gctgggcttg gggctgcctg tggagaggcg gcgggcggaa cgcgcgcggc      120

cacggccacg gccaccgcca cggccacggc cggcagctcg ggtcccgggt cccgggcagg      180

ggaaggggag aggcggcgag ctcagcaacc ggaaccgagg gaagattttg gctccgcggg      240

ctcgccctcc gctccctctg ccagcggcgc cagacgccga gtggggccag ggacagggga      300

ggaggaccca ggaccctgtg cccgcgcccc tggagccgct ggagttcgga cttctgcaac      360

tgttggcact ttgggggctt ggcttagcgc tctgctgttt acccgtctct cctcgctgcc      420

tcggaaccaa agctcccggc cccctccgcc ctcgcgcgcc cacccaccgc cgccggggag      480

cggcccggcc cgcactcagc accatgaggg gacttgggac ttgcctggcg actttggccg      540

gacttttgct aactgcggcg ggcgagacgt tctcaggtgg ctgcctcttt gatgagccgt      600

atagcacatg tggatatagt caatctgaag gtgatgactt caattgggag caagtgaaca      660

ccttgactaa accgacttct gatccatgga tgccatcagg ttctttcatg ctggtgaatg      720

cctctgggag acctgagggg cagagagccc acctgctctt accccaactt aaagaaaatg      780

acacccactg catcgatttt cactattttg tgtccagcaa gagtaattct cctccggggt      840

tactcaatgt ctacgtgaag gtcaataacg ggccactggg gaatcctatc tggaatatat      900

ctggagaccc aacacgtaca tggaacaggg cagaactggc cattagtact ttctggccta      960

acttttatca ggtgattttt gaagtgataa cttctggaca tcaaggctat ctcgctatcg     1020

atgaggtgaa ggtgttagga catccatgta ccaggactcc tcacttcctg cggattcaga     1080

atgtggaagt taatgctggc cagtttgcta ccttccagtg cagtgccatc ggcaggaccg     1140

tggcaggaga caggctctgg ttacagggca ttgatgtgcg agatgctcct ctgaaggaaa     1200

tcaaggtgac cagctcccga cgcttcattg cttcatttaa tgttgtgaat accaccaaac     1260

gagatgctgg aaagtaccgc tgcatgattc gcactgaagg aggtgttgga atatcaaact     1320

atgcagagtt ggtagttaaa gaaccacccg ttcctattgc cccacctcag ctcgcctctg     1380

taggagccac ctacctgtgg atacagctca acgccaactc catcaatggg gatgggccca     1440

ttgtggcccg agaggtggag tactgcacgg ccagtgggag ctggaatgac cggcagccag     1500

tcgattccac gagctataaa attggacacc ttgacccaga tacagaatat gagattagtg     1560

tgctcctgac caggccaggg gagggtggca ctggctctcc tggtccagct ctcaggacaa     1620

gaacaaagtg tgctgatccc atgcgaggcc caagaaaact agaagtagtg gaggtcaaat     1680

ctcggcaaat cactatccgc tgggagccat ttggatataa tgtaactcgt tgccacagtt     1740

ataatctcac tgtccactac tgttaccaag ttggaggaca agaacaagtg cgagaagaag     1800

taagctggga tacagaaaac tcacaccctc aacacacgat cactaacctg tcaccataca     1860

ccaatgtcag tgtgaaactg atcctcatga acccagaggg ccggaaggaa agccaagaac     1920

tcatagtgca gacagatgaa gacctcccag gtgctgttcc cactgaatcc atacaaggaa     1980

gtacctttga agagaagata tttcttcagt ggagagaacc aactcaaaca tatggtgtaa     2040

tcactttata tgagatcacc tacaaagcag tcagttcctt tgacccagaa atagatttat     2100

ccaatcagag tggaagagtt tcaaagctgg gaaatgaaac ccattttctg ttttttggac     2160

tgtatccggg gaccacatac tcctttacca tccgagctag cacagctaag ggttttgggc     2220

ctccagcaac aaaccagttc accaccaaaa tatcagcacc ctctatgcca gcttatgaac     2280

ttgagacacc tttgaatcaa actgacaata ccgtgacagt catgctgaaa cctgcccaca     2340

gcagaggagc acctgtcagt gtctatcaaa tagttgttga ggaagaacgt cctcgaagaa     2400

ctaaaaagac gacagaaatc ttaaagtgct acccagtgcc aattcacttc cagaatgctt     2460

ctctgctgaa ctcacagtac tactttgctg cagaatttcc tgcagacagc ctccaagctg     2520

cgcagccttt tacaattggt gataataaga catataatgg atactggaac actccccttc     2580

tcccctataa aagctacaga atttatttcc aagctgctag tagagccaat ggggaaacca     2640

aaatagactg tgtccaagtg gccacaaaag gagctgccac tccgaaacca gtcccagaac     2700

ccgagaaaca gacagaccat acagttaaaa ttgctggagt catcgcgggc atcttgctgt     2760

tcgtgattat atttcttgga gttgtgttgg taatgaagaa aaggaaactg gccaagaagc     2820

ggaaagagac catgagcagc acccgacagg agatgactgt gatggtgaac tcaatggaca     2880

agagctatgc tgagcagggc acaaactgcg acgaggcttt ctcattcatg gacacgcaca     2940

atctgaatgg gagatctgtg tcttcaccat cgtccttcac aatgaaaaca aatacactga     3000

gcacatcggt gcctaattcc tattacccag acccatttgt gccaactgca attttagtgc     3060

caataaatga tgaaacccac acaatggcca gcgataccag cagcctggtg cagtcccata     3120

cttacaagaa gcgagagccg gccgacgtgc cctatcagac tgggcagctc caccccgcca     3180

tccgggtggc agacctcctt cagcacatca cacagatgaa gtgtgcggag ggctacggct     3240

tcaaggagga atacgagagc ttctttgaag ggcagtctgc accatgggac tcggctaaga     3300

aagatgagaa cagaatgaag aacagatacg ggaatatcat tgcatacgat cattcccgag     3360

tgaggctgca gacaatagaa ggagacacaa actcagacta tatcaatggc aattatatcg     3420

atggttatca tcgacccaat cattacattg ctacccaagg gccaatgcag gaaaccatct     3480

atgacttctg gaggatggtg tggcacgaaa acactgcaag tatcatcatg gtgaccaatc     3540

ttgtggaagt gggaagggtc aaatgctgca aatactggcc agatgacaca gagatatata     3600

aagacattaa agttacccta atagaaacag aactactggc agaatatgtg ataagaacat     3660

ttgctgttga aaagagaggt gtgcatgaaa tccgagagat cagacagttt cacttcactg     3720

gctggccgga tcatggggtc ccctaccatg ccaccggcct gctgggattc gtgcggcaag     3780

tcaagtccaa gagcccgccc agtgcaggcc cactggtggt gcactgcagt gctggtgcag     3840

ggaggactgg ctgtttcatc gtcattgata tcatgttgga catggccgaa agggaagggg     3900

tcgtagacat ctacaactgc gtcagggagc tgcggtcacg gagggtgaac atggtgcaaa     3960

cagaggagca gtatgtgttt atccacgatg cgatcctgga agcctgtctt tgtggggaca     4020

cctctgtgcc tgcttcccaa gttaggtctc tgtattatga catgaacaaa ctggatccac     4080

agacaaactc aagccagatt aaagaggaat tccggacgct aaacatggtg acaccaacgc     4140

tgcgagtaga ggactgcagc atcgcactgt tgccccggaa ccatgagaaa aaccggtgca     4200

tggacatcct gcccccagac cgctgcctgc ccttcctcat caccatcgat ggggagagca     4260

gcaactacat caatgctgcc ctcatggaca gctataaaca gccttcagct tttatagtca     4320

cccagcatcc tttgccaaac acagtgaaag acttttggag actggtcctg gattatcact     4380

gcacatccgt agttatgcta aatgatgtgg atcctgccca gttgtgtcca cagtactggc     4440

cagaaaacgg agtacacaga cacggcccca tccaggtgga atttgtctct gctgacctgg     4500

aagaggacat catcagcagg atattccgca tttacaatgc cgccagaccc caagatggat     4560

atcggatggt gcagcaattc cagttcctgg gctggccgat gtacagggac acaccagtgt     4620

ctaagcgctc cttcttgaag ctcattcgcc aggtggacaa gtggcaagag gagtacaatg     4680

gcggggaagg ccgcacggtt gtgcactgct tgaacggggg aggccgcagt gggacgttct     4740

gcgccatcag catcgtatgt gagatgctcc ggcaccagag aaccgtggat gtctttcacg     4800

ctgtgaagac actgaggaac aacaagccca acatggtcga cctcctggat cagtacaagt     4860

tctgctacga ggtggccctg gaatacttga attctggctg atggtgtaaa cagctctgca     4920

aacaatccct ttcataccac aaagccaaga cgttccatgg tatttgtgca aaagagatga     4980

agacttctca atatgcttat tttgctttgc ataattggct ctttttaaga gcccaagaaa     5040

gtgtttctaa aattgcttgc actgcccaat cccagtaatg ctgctgcctg acagaaacac     5100

acacacagcc acagttgcca aatcccgtac tccttgccac cggcttccta gagcagcgta     5160

gacagctggt aaactgaaga gcacaactat attcttatga aggaatttgt acctttgggg     5220

tattattttg tggcccgtga ccctcgttat tgttacagct gagtgtatgt ttttgttctg     5280

tggagaatgc tatctggcat tatggtaata tattatttta ggtaatattt gtactttaac     5340

atgttgcata atatatgctt atgtagcttt ccaggactaa cagataaatg tgtaatgaac     5400

aaagatatgt tgtatgagtc gtcgtttctg tcagatttgt attgtttcca agggaaaagc     5460

ttgggggagg actcagttca caaaatgcaa aactcaacga tcagattcac ggacccagag     5520

cttttccatg tgtttatatt gtaaatattt ttgatttcat caaattattt attcattaaa     5580

agaaattttt gtgaagcaca aaaaaaaaaa aaaaaaaaaa aaaa                      5624


<210>  37
<211>  1465
<212>  PRT
<213>  homo sapiens

<400>  37

Met Arg Gly Leu Gly Thr Cys Leu Ala Thr Leu Ala Gly Leu Leu Leu 
1               5                   10                  15      


Thr Ala Ala Gly Glu Thr Phe Ser Gly Gly Cys Leu Phe Asp Glu Pro 
            20                  25                  30          


Tyr Ser Thr Cys Gly Tyr Ser Gln Ser Glu Gly Asp Asp Phe Asn Trp 
        35                  40                  45              


Glu Gln Val Asn Thr Leu Thr Lys Pro Thr Ser Asp Pro Trp Met Pro 
    50                  55                  60                  


Ser Gly Ser Phe Met Leu Val Asn Ala Ser Gly Arg Pro Glu Gly Gln 
65                  70                  75                  80  


Arg Ala His Leu Leu Leu Pro Gln Leu Lys Glu Asn Asp Thr His Cys 
                85                  90                  95      


Ile Asp Phe His Tyr Phe Val Ser Ser Lys Ser Asn Ser Pro Pro Gly 
            100                 105                 110         


Leu Leu Asn Val Tyr Val Lys Val Asn Asn Gly Pro Leu Gly Asn Pro 
        115                 120                 125             


Ile Trp Asn Ile Ser Gly Asp Pro Thr Arg Thr Trp Asn Arg Ala Glu 
    130                 135                 140                 


Leu Ala Ile Ser Thr Phe Trp Pro Asn Phe Tyr Gln Val Ile Phe Glu 
145                 150                 155                 160 


Val Ile Thr Ser Gly His Gln Gly Tyr Leu Ala Ile Asp Glu Val Lys 
                165                 170                 175     


Val Leu Gly His Pro Cys Thr Arg Thr Pro His Phe Leu Arg Ile Gln 
            180                 185                 190         


Asn Val Glu Val Asn Ala Gly Gln Phe Ala Thr Phe Gln Cys Ser Ala 
        195                 200                 205             


Ile Gly Arg Thr Val Ala Gly Asp Arg Leu Trp Leu Gln Gly Ile Asp 
    210                 215                 220                 


Val Arg Asp Ala Pro Leu Lys Glu Ile Lys Val Thr Ser Ser Arg Arg 
225                 230                 235                 240 


Phe Ile Ala Ser Phe Asn Val Val Asn Thr Thr Lys Arg Asp Ala Gly 
                245                 250                 255     


Lys Tyr Arg Cys Met Ile Arg Thr Glu Gly Gly Val Gly Ile Ser Asn 
            260                 265                 270         


Tyr Ala Glu Leu Val Val Lys Glu Pro Pro Val Pro Ile Ala Pro Pro 
        275                 280                 285             


Gln Leu Ala Ser Val Gly Ala Thr Tyr Leu Trp Ile Gln Leu Asn Ala 
    290                 295                 300                 


Asn Ser Ile Asn Gly Asp Gly Pro Ile Val Ala Arg Glu Val Glu Tyr 
305                 310                 315                 320 


Cys Thr Ala Ser Gly Ser Trp Asn Asp Arg Gln Pro Val Asp Ser Thr 
                325                 330                 335     


Ser Tyr Lys Ile Gly His Leu Asp Pro Asp Thr Glu Tyr Glu Ile Ser 
            340                 345                 350         


Val Leu Leu Thr Arg Pro Gly Glu Gly Gly Thr Gly Ser Pro Gly Pro 
        355                 360                 365             


Ala Leu Arg Thr Arg Thr Lys Cys Ala Asp Pro Met Arg Gly Pro Arg 
    370                 375                 380                 


Lys Leu Glu Val Val Glu Val Lys Ser Arg Gln Ile Thr Ile Arg Trp 
385                 390                 395                 400 


Glu Pro Phe Gly Tyr Asn Val Thr Arg Cys His Ser Tyr Asn Leu Thr 
                405                 410                 415     


Val His Tyr Cys Tyr Gln Val Gly Gly Gln Glu Gln Val Arg Glu Glu 
            420                 425                 430         


Val Ser Trp Asp Thr Glu Asn Ser His Pro Gln His Thr Ile Thr Asn 
        435                 440                 445             


Leu Ser Pro Tyr Thr Asn Val Ser Val Lys Leu Ile Leu Met Asn Pro 
    450                 455                 460                 


Glu Gly Arg Lys Glu Ser Gln Glu Leu Ile Val Gln Thr Asp Glu Asp 
465                 470                 475                 480 


Leu Pro Gly Ala Val Pro Thr Glu Ser Ile Gln Gly Ser Thr Phe Glu 
                485                 490                 495     


Glu Lys Ile Phe Leu Gln Trp Arg Glu Pro Thr Gln Thr Tyr Gly Val 
            500                 505                 510         


Ile Thr Leu Tyr Glu Ile Thr Tyr Lys Ala Val Ser Ser Phe Asp Pro 
        515                 520                 525             


Glu Ile Asp Leu Ser Asn Gln Ser Gly Arg Val Ser Lys Leu Gly Asn 
    530                 535                 540                 


Glu Thr His Phe Leu Phe Phe Gly Leu Tyr Pro Gly Thr Thr Tyr Ser 
545                 550                 555                 560 


Phe Thr Ile Arg Ala Ser Thr Ala Lys Gly Phe Gly Pro Pro Ala Thr 
                565                 570                 575     


Asn Gln Phe Thr Thr Lys Ile Ser Ala Pro Ser Met Pro Ala Tyr Glu 
            580                 585                 590         


Leu Glu Thr Pro Leu Asn Gln Thr Asp Asn Thr Val Thr Val Met Leu 
        595                 600                 605             


Lys Pro Ala His Ser Arg Gly Ala Pro Val Ser Val Tyr Gln Ile Val 
    610                 615                 620                 


Val Glu Glu Glu Arg Pro Arg Arg Thr Lys Lys Thr Thr Glu Ile Leu 
625                 630                 635                 640 


Lys Cys Tyr Pro Val Pro Ile His Phe Gln Asn Ala Ser Leu Leu Asn 
                645                 650                 655     


Ser Gln Tyr Tyr Phe Ala Ala Glu Phe Pro Ala Asp Ser Leu Gln Ala 
            660                 665                 670         


Ala Gln Pro Phe Thr Ile Gly Asp Asn Lys Thr Tyr Asn Gly Tyr Trp 
        675                 680                 685             


Asn Thr Pro Leu Leu Pro Tyr Lys Ser Tyr Arg Ile Tyr Phe Gln Ala 
    690                 695                 700                 


Ala Ser Arg Ala Asn Gly Glu Thr Lys Ile Asp Cys Val Gln Val Ala 
705                 710                 715                 720 


Thr Lys Gly Ala Ala Thr Pro Lys Pro Val Pro Glu Pro Glu Lys Gln 
                725                 730                 735     


Thr Asp His Thr Val Lys Ile Ala Gly Val Ile Ala Gly Ile Leu Leu 
            740                 745                 750         


Phe Val Ile Ile Phe Leu Gly Val Val Leu Val Met Lys Lys Arg Lys 
        755                 760                 765             


Leu Ala Lys Lys Arg Lys Glu Thr Met Ser Ser Thr Arg Gln Glu Met 
    770                 775                 780                 


Thr Val Met Val Asn Ser Met Asp Lys Ser Tyr Ala Glu Gln Gly Thr 
785                 790                 795                 800 


Asn Cys Asp Glu Ala Phe Ser Phe Met Asp Thr His Asn Leu Asn Gly 
                805                 810                 815     


Arg Ser Val Ser Ser Pro Ser Ser Phe Thr Met Lys Thr Asn Thr Leu 
            820                 825                 830         


Ser Thr Ser Val Pro Asn Ser Tyr Tyr Pro Asp Pro Phe Val Pro Thr 
        835                 840                 845             


Ala Ile Leu Val Pro Ile Asn Asp Glu Thr His Thr Met Ala Ser Asp 
    850                 855                 860                 


Thr Ser Ser Leu Val Gln Ser His Thr Tyr Lys Lys Arg Glu Pro Ala 
865                 870                 875                 880 


Asp Val Pro Tyr Gln Thr Gly Gln Leu His Pro Ala Ile Arg Val Ala 
                885                 890                 895     


Asp Leu Leu Gln His Ile Thr Gln Met Lys Cys Ala Glu Gly Tyr Gly 
            900                 905                 910         


Phe Lys Glu Glu Tyr Glu Ser Phe Phe Glu Gly Gln Ser Ala Pro Trp 
        915                 920                 925             


Asp Ser Ala Lys Lys Asp Glu Asn Arg Met Lys Asn Arg Tyr Gly Asn 
    930                 935                 940                 


Ile Ile Ala Tyr Asp His Ser Arg Val Arg Leu Gln Thr Ile Glu Gly 
945                 950                 955                 960 


Asp Thr Asn Ser Asp Tyr Ile Asn Gly Asn Tyr Ile Asp Gly Tyr His 
                965                 970                 975     


Arg Pro Asn His Tyr Ile Ala Thr Gln Gly Pro Met Gln Glu Thr Ile 
            980                 985                 990         


Tyr Asp Phe Trp Arg Met Val Trp  His Glu Asn Thr Ala  Ser Ile Ile 
        995                 1000                 1005             


Met Val  Thr Asn Leu Val Glu  Val Gly Arg Val Lys  Cys Cys Lys 
    1010                 1015                 1020             


Tyr Trp  Pro Asp Asp Thr Glu  Ile Tyr Lys Asp Ile  Lys Val Thr 
    1025                 1030                 1035             


Leu Ile  Glu Thr Glu Leu Leu  Ala Glu Tyr Val Ile  Arg Thr Phe 
    1040                 1045                 1050             


Ala Val  Glu Lys Arg Gly Val  His Glu Ile Arg Glu  Ile Arg Gln 
    1055                 1060                 1065             


Phe His  Phe Thr Gly Trp Pro  Asp His Gly Val Pro  Tyr His Ala 
    1070                 1075                 1080             


Thr Gly  Leu Leu Gly Phe Val  Arg Gln Val Lys Ser  Lys Ser Pro 
    1085                 1090                 1095             


Pro Ser  Ala Gly Pro Leu Val  Val His Cys Ser Ala  Gly Ala Gly 
    1100                 1105                 1110             


Arg Thr  Gly Cys Phe Ile Val  Ile Asp Ile Met Leu  Asp Met Ala 
    1115                 1120                 1125             


Glu Arg  Glu Gly Val Val Asp  Ile Tyr Asn Cys Val  Arg Glu Leu 
    1130                 1135                 1140             


Arg Ser  Arg Arg Val Asn Met  Val Gln Thr Glu Glu  Gln Tyr Val 
    1145                 1150                 1155             


Phe Ile  His Asp Ala Ile Leu  Glu Ala Cys Leu Cys  Gly Asp Thr 
    1160                 1165                 1170             


Ser Val  Pro Ala Ser Gln Val  Arg Ser Leu Tyr Tyr  Asp Met Asn 
    1175                 1180                 1185             


Lys Leu  Asp Pro Gln Thr Asn  Ser Ser Gln Ile Lys  Glu Glu Phe 
    1190                 1195                 1200             


Arg Thr  Leu Asn Met Val Thr  Pro Thr Leu Arg Val  Glu Asp Cys 
    1205                 1210                 1215             


Ser Ile  Ala Leu Leu Pro Arg  Asn His Glu Lys Asn  Arg Cys Met 
    1220                 1225                 1230             


Asp Ile  Leu Pro Pro Asp Arg  Cys Leu Pro Phe Leu  Ile Thr Ile 
    1235                 1240                 1245             


Asp Gly  Glu Ser Ser Asn Tyr  Ile Asn Ala Ala Leu  Met Asp Ser 
    1250                 1255                 1260             


Tyr Lys  Gln Pro Ser Ala Phe  Ile Val Thr Gln His  Pro Leu Pro 
    1265                 1270                 1275             


Asn Thr  Val Lys Asp Phe Trp  Arg Leu Val Leu Asp  Tyr His Cys 
    1280                 1285                 1290             


Thr Ser  Val Val Met Leu Asn  Asp Val Asp Pro Ala  Gln Leu Cys 
    1295                 1300                 1305             


Pro Gln  Tyr Trp Pro Glu Asn  Gly Val His Arg His  Gly Pro Ile 
    1310                 1315                 1320             


Gln Val  Glu Phe Val Ser Ala  Asp Leu Glu Glu Asp  Ile Ile Ser 
    1325                 1330                 1335             


Arg Ile  Phe Arg Ile Tyr Asn  Ala Ala Arg Pro Gln  Asp Gly Tyr 
    1340                 1345                 1350             


Arg Met  Val Gln Gln Phe Gln  Phe Leu Gly Trp Pro  Met Tyr Arg 
    1355                 1360                 1365             


Asp Thr  Pro Val Ser Lys Arg  Ser Phe Leu Lys Leu  Ile Arg Gln 
    1370                 1375                 1380             


Val Asp  Lys Trp Gln Glu Glu  Tyr Asn Gly Gly Glu  Gly Arg Thr 
    1385                 1390                 1395             


Val Val  His Cys Leu Asn Gly  Gly Gly Arg Ser Gly  Thr Phe Cys 
    1400                 1405                 1410             


Ala Ile  Ser Ile Val Cys Glu  Met Leu Arg His Gln  Arg Thr Val 
    1415                 1420                 1425             


Asp Val  Phe His Ala Val Lys  Thr Leu Arg Asn Asn  Lys Pro Asn 
    1430                 1435                 1440             


Met Val  Asp Leu Leu Asp Gln  Tyr Lys Phe Cys Tyr  Glu Val Ala 
    1445                 1450                 1455             


Leu Glu  Tyr Leu Asn Ser Gly  
    1460                 1465 


<210>  38
<211>  5585
<212>  DNA
<213>  homo sapiens

<400>  38
agtcagtcgg ggagcaagag ccccgcgcgc agccggcgcg ggctcggtca tcggcgcgcc       60

gccgcccggg gctgggcttg gggctgcctg tggagaggcg gcgggcggaa cgcgcgcggc      120

cacggccacg gccaccgcca cggccacggc cggcagctcg ggtcccgggt cccgggcagg      180

ggaaggggag aggcggcgag ctcagcaacc ggaaccgagg gaagattttg gctccgcggg      240

ctcgccctcc gctccctctg ccagcggcgc cagacgccga gtggggccag ggacagggga      300

ggaggaccca ggaccctgtg cccgcgcccc tggagccgct ggagttcgga cttctgcaac      360

tgttggcact ttgggggctt ggcttagcgc tctgctgttt acccgtctct cctcgctgcc      420

tcggaaccaa agctcccggc cccctccgcc ctcgcgcgcc cacccaccgc cgccggggag      480

cggcccggcc cgcactcagc accatgaggg gacttgggac ttgcctggcg actttggccg      540

gacttttgct aactgcggcg ggcgagacgt tctcaggtgg ctgcctcttt gatgagccgt      600

atagcacatg tggatatagt caatctgaag gtgatgactt caattgggag caagtgaaca      660

ccttgactaa accgacttct gatccatgga tgccatcagg ttctttcatg ctggtgaatg      720

cctctgggag acctgagggg cagagagccc acctgctctt accccaactt aaagaaaatg      780

acacccactg catcgatttt cactattttg tgtccagcaa gagtaattct cctccggggt      840

tactcaatgt ctacgtgaag gtcaataacg ggccactggg gaatcctatc tggaatatat      900

ctggagaccc aacacgtaca tggaacaggg cagaactggc cattagtact ttctggccta      960

acttttatca ggtgattttt gaagtgataa cttctggaca tcaaggctat ctcgctatcg     1020

atgaggtgaa ggtgttagga catccatgta ccaggactcc tcacttcctg cggattcaga     1080

atgtggaagt taatgctggc cagtttgcta ccttccagtg cagtgccatc ggcaggaccg     1140

tggcaggaga caggctctgg ttacagggca ttgatgtgcg agatgctcct ctgaaggaaa     1200

tcaaggtgac cagctcccga cgcttcattg cttcatttaa tgttgtgaat accaccaaac     1260

gagatgctgg aaagtaccgc tgcatgattc gcactgaagg aggtgttgga atatcaaact     1320

atgcagagtt ggtagttaaa gaaccacccg ttcctattgc cccacctcag ctcgcctctg     1380

taggagccac ctacctgtgg atacagctca acgccaactc catcaatggg gatgggccca     1440

ttgtggcccg agaggtggag tactgcacgg ccagtgggag ctggaatgac cggcagccag     1500

tcgattccac gagctataaa attggacacc ttgacccaga tacagaatat gagattagtg     1560

tgctcctgac caggccaggg gagggtggca ctggctctcc tggtccagct ctcaggacaa     1620

gaacaaagtg tgctgatccc atgcgaggcc caagaaaact agaagtagtg gaggtcaaat     1680

ctcggcaaat cactatccgc tgggagccat ttggatataa tgtaactcgt tgccacagtt     1740

ataatctcac tgtccactac tgttaccaag ttggaggaca agaacaagtg cgagaagaag     1800

taagctggga tacagaaaac tcacaccctc aacacacgat cactaacctg tcaccataca     1860

ccaatgtcag tgtgaaactg atcctcatga acccagaggg ccggaaggaa agccaagaac     1920

tcatagtgca gacagatgaa gacctcccag gtgctgttcc cactgaatcc atacaaggaa     1980

gtacctttga agagaagata tttcttcagt ggagagaacc aactcaaaca tatggtgtaa     2040

tcactttata tgagatcacc tacaaagcag tcagttcctt tgacccagaa atagatttat     2100

ccaatcagag tggaagagtt tcaaagctgg gaaatgaaac ccattttctg ttttttggac     2160

tgtatccggg gaccacatac tcctttacca tccgagctag cacagctaag ggttttgggc     2220

ctccagcaac aaaccagttc accaccaaaa tatcagcacc ctctatgcca gcttatgaac     2280

ttgagacacc tttgaatcaa actgacaata ccgtgacagt catgctgaaa cctgcccaca     2340

gcagaggagc acctgtcagt gtctatcaaa tagttgttga ggaagaacgt cctcgaagaa     2400

ctaaaaagac gacagaaatc ttaaagtgct acccagtgcc aattcacttc cagaatgctt     2460

ctctgctgaa ctcacagtac tactttgctg cagaatttcc tgcagacagc ctccaagctg     2520

cgcagccttt tacaattggt gataataaga catataatgg atactggaac actccccttc     2580

tcccctataa aagctacaga atttatttcc aagctgctag tagagccaat ggggaaacca     2640

aaatagactg tgtccaagtg gccacaaaag gagctgccac tccgaaacca gtcccagaac     2700

ccgagaaaca gacagaccat acagttaaaa ttgctggagt catcgcgggc atcttgctgt     2760

tcgtgattat atttcttgga gttgtgttgg taatgaagaa aaggaaactg gccaagaagc     2820

ggaaagagac catgagcagc acccgacagg agatgactgt gatggtgaac tcaatggaca     2880

agagctatgc tgagcagggc acaaactgcg acgaggcttt ctcattcatg gacacgcaca     2940

atctgaatgg gagatctgtg tcttcaccat cgtccttcac aatgaaaaca aatacactga     3000

gcacatcggt gcctaattcc tattacccag atgaaaccca cacaatggcc agcgatacca     3060

gcagcctggt gcagtcccat acttacaaga agcgagagcc ggccgacgtg ccctatcaga     3120

ctgggcagct ccaccccgcc atccgggtgg cagacctcct tcagcacatc acacagatga     3180

agtgtgcgga gggctacggc ttcaaggagg aatacgagag cttctttgaa gggcagtctg     3240

caccatggga ctcggctaag aaagatgaga acagaatgaa gaacagatac gggaatatca     3300

ttgcatacga tcattcccga gtgaggctgc agacaataga aggagacaca aactcagact     3360

atatcaatgg caattatatc gatggttatc atcgacccaa tcattacatt gctacccaag     3420

ggccaatgca ggaaaccatc tatgacttct ggaggatggt gtggcacgaa aacactgcaa     3480

gtatcatcat ggtgaccaat cttgtggaag tgggaagggt caaatgctgc aaatactggc     3540

cagatgacac agagatatat aaagacatta aagttaccct aatagaaaca gaactactgg     3600

cagaatatgt gataagaaca tttgctgttg aaaagagagg tgtgcatgaa atccgagaga     3660

tcagacagtt tcacttcact ggctggccgg atcatggggt cccctaccat gccaccggcc     3720

tgctgggatt cgtgcggcaa gtcaagtcca agagcccgcc cagtgcaggc ccactggtgg     3780

tgcactgcag tgctggtgca gggaggactg gctgtttcat cgtcattgat atcatgttgg     3840

acatggccga aagggaaggg gtcgtagaca tctacaactg cgtcagggag ctgcggtcac     3900

ggagggtgaa catggtgcaa acagaggagc agtatgtgtt tatccacgat gcgatcctgg     3960

aagcctgtct ttgtggggac acctctgtgc ctgcttccca agttaggtct ctgtattatg     4020

acatgaacaa actggatcca cagacaaact caagccagat taaagaggaa ttccggacgc     4080

taaacatggt gacaccaacg ctgcgagtag aggactgcag catcgcactg ttgccccgga     4140

accatgagaa aaaccggtgc atggacatcc tgcccccaga ccgctgcctg cccttcctca     4200

tcaccatcga tggggagagc agcaactaca tcaatgctgc cctcatggac agctataaac     4260

agccttcagc ttttatagtc acccagcatc ctttgccaaa cacagtgaaa gacttttgga     4320

gactggtcct ggattatcac tgcacatccg tagttatgct aaatgatgtg gatcctgccc     4380

agttgtgtcc acagtactgg ccagaaaacg gagtacacag acacggcccc atccaggtgg     4440

aatttgtctc tgctgacctg gaagaggaca tcatcagcag gatattccgc atttacaatg     4500

ccgccagacc ccaagatgga tatcggatgg tgcagcaatt ccagttcctg ggctggccga     4560

tgtacaggga cacaccagtg tctaagcgct ccttcttgaa gctcattcgc caggtggaca     4620

agtggcaaga ggagtacaat ggcggggaag gccgcacggt tgtgcactgc ttgaacgggg     4680

gaggccgcag tgggacgttc tgcgccatca gcatcgtatg tgagatgctc cggcaccaga     4740

gaaccgtgga tgtctttcac gctgtgaaga cactgaggaa caacaagccc aacatggtcg     4800

acctcctgga tcagtacaag ttctgctacg aggtggccct ggaatacttg aattctggct     4860

gatggtgtaa acagctctgc aaacaatccc tttcatacca caaagccaag acgttccatg     4920

gtatttgtgc aaaagagatg aagacttctc aatatgctta ttttgctttg cataattggc     4980

tctttttaag agcccaagaa agtgtttcta aaattgcttg cactgcccaa tcccagtaat     5040

gctgctgcct gacagaaaca cacacacagc cacagttgcc aaatcccgta ctccttgcca     5100

ccggcttcct agagcagcgt agacagctgg taaactgaag agcacaacta tattcttatg     5160

aaggaatttg tacctttggg gtattatttt gtggcccgtg accctcgtta ttgttacagc     5220

tgagtgtatg tttttgttct gtggagaatg ctatctggca ttatggtaat atattatttt     5280

aggtaatatt tgtactttaa catgttgcat aatatatgct tatgtagctt tccaggacta     5340

acagataaat gtgtaatgaa caaagatatg ttgtatgagt cgtcgtttct gtcagatttg     5400

tattgtttcc aagggaaaag cttgggggag gactcagttc acaaaatgca aaactcaacg     5460

atcagattca cggacccaga gcttttccat gtgtttatat tgtaaatatt tttgatttca     5520

tcaaattatt tattcattaa aagaaatttt tgtgaagcac aaaaaaaaaa aaaaaaaaaa     5580

aaaaa                                                                 5585


<210>  39
<211>  1452
<212>  PRT
<213>  homo sapiens

<400>  39

Met Arg Gly Leu Gly Thr Cys Leu Ala Thr Leu Ala Gly Leu Leu Leu 
1               5                   10                  15      


Thr Ala Ala Gly Glu Thr Phe Ser Gly Gly Cys Leu Phe Asp Glu Pro 
            20                  25                  30          


Tyr Ser Thr Cys Gly Tyr Ser Gln Ser Glu Gly Asp Asp Phe Asn Trp 
        35                  40                  45              


Glu Gln Val Asn Thr Leu Thr Lys Pro Thr Ser Asp Pro Trp Met Pro 
    50                  55                  60                  


Ser Gly Ser Phe Met Leu Val Asn Ala Ser Gly Arg Pro Glu Gly Gln 
65                  70                  75                  80  


Arg Ala His Leu Leu Leu Pro Gln Leu Lys Glu Asn Asp Thr His Cys 
                85                  90                  95      


Ile Asp Phe His Tyr Phe Val Ser Ser Lys Ser Asn Ser Pro Pro Gly 
            100                 105                 110         


Leu Leu Asn Val Tyr Val Lys Val Asn Asn Gly Pro Leu Gly Asn Pro 
        115                 120                 125             


Ile Trp Asn Ile Ser Gly Asp Pro Thr Arg Thr Trp Asn Arg Ala Glu 
    130                 135                 140                 


Leu Ala Ile Ser Thr Phe Trp Pro Asn Phe Tyr Gln Val Ile Phe Glu 
145                 150                 155                 160 


Val Ile Thr Ser Gly His Gln Gly Tyr Leu Ala Ile Asp Glu Val Lys 
                165                 170                 175     


Val Leu Gly His Pro Cys Thr Arg Thr Pro His Phe Leu Arg Ile Gln 
            180                 185                 190         


Asn Val Glu Val Asn Ala Gly Gln Phe Ala Thr Phe Gln Cys Ser Ala 
        195                 200                 205             


Ile Gly Arg Thr Val Ala Gly Asp Arg Leu Trp Leu Gln Gly Ile Asp 
    210                 215                 220                 


Val Arg Asp Ala Pro Leu Lys Glu Ile Lys Val Thr Ser Ser Arg Arg 
225                 230                 235                 240 


Phe Ile Ala Ser Phe Asn Val Val Asn Thr Thr Lys Arg Asp Ala Gly 
                245                 250                 255     


Lys Tyr Arg Cys Met Ile Arg Thr Glu Gly Gly Val Gly Ile Ser Asn 
            260                 265                 270         


Tyr Ala Glu Leu Val Val Lys Glu Pro Pro Val Pro Ile Ala Pro Pro 
        275                 280                 285             


Gln Leu Ala Ser Val Gly Ala Thr Tyr Leu Trp Ile Gln Leu Asn Ala 
    290                 295                 300                 


Asn Ser Ile Asn Gly Asp Gly Pro Ile Val Ala Arg Glu Val Glu Tyr 
305                 310                 315                 320 


Cys Thr Ala Ser Gly Ser Trp Asn Asp Arg Gln Pro Val Asp Ser Thr 
                325                 330                 335     


Ser Tyr Lys Ile Gly His Leu Asp Pro Asp Thr Glu Tyr Glu Ile Ser 
            340                 345                 350         


Val Leu Leu Thr Arg Pro Gly Glu Gly Gly Thr Gly Ser Pro Gly Pro 
        355                 360                 365             


Ala Leu Arg Thr Arg Thr Lys Cys Ala Asp Pro Met Arg Gly Pro Arg 
    370                 375                 380                 


Lys Leu Glu Val Val Glu Val Lys Ser Arg Gln Ile Thr Ile Arg Trp 
385                 390                 395                 400 


Glu Pro Phe Gly Tyr Asn Val Thr Arg Cys His Ser Tyr Asn Leu Thr 
                405                 410                 415     


Val His Tyr Cys Tyr Gln Val Gly Gly Gln Glu Gln Val Arg Glu Glu 
            420                 425                 430         


Val Ser Trp Asp Thr Glu Asn Ser His Pro Gln His Thr Ile Thr Asn 
        435                 440                 445             


Leu Ser Pro Tyr Thr Asn Val Ser Val Lys Leu Ile Leu Met Asn Pro 
    450                 455                 460                 


Glu Gly Arg Lys Glu Ser Gln Glu Leu Ile Val Gln Thr Asp Glu Asp 
465                 470                 475                 480 


Leu Pro Gly Ala Val Pro Thr Glu Ser Ile Gln Gly Ser Thr Phe Glu 
                485                 490                 495     


Glu Lys Ile Phe Leu Gln Trp Arg Glu Pro Thr Gln Thr Tyr Gly Val 
            500                 505                 510         


Ile Thr Leu Tyr Glu Ile Thr Tyr Lys Ala Val Ser Ser Phe Asp Pro 
        515                 520                 525             


Glu Ile Asp Leu Ser Asn Gln Ser Gly Arg Val Ser Lys Leu Gly Asn 
    530                 535                 540                 


Glu Thr His Phe Leu Phe Phe Gly Leu Tyr Pro Gly Thr Thr Tyr Ser 
545                 550                 555                 560 


Phe Thr Ile Arg Ala Ser Thr Ala Lys Gly Phe Gly Pro Pro Ala Thr 
                565                 570                 575     


Asn Gln Phe Thr Thr Lys Ile Ser Ala Pro Ser Met Pro Ala Tyr Glu 
            580                 585                 590         


Leu Glu Thr Pro Leu Asn Gln Thr Asp Asn Thr Val Thr Val Met Leu 
        595                 600                 605             


Lys Pro Ala His Ser Arg Gly Ala Pro Val Ser Val Tyr Gln Ile Val 
    610                 615                 620                 


Val Glu Glu Glu Arg Pro Arg Arg Thr Lys Lys Thr Thr Glu Ile Leu 
625                 630                 635                 640 


Lys Cys Tyr Pro Val Pro Ile His Phe Gln Asn Ala Ser Leu Leu Asn 
                645                 650                 655     


Ser Gln Tyr Tyr Phe Ala Ala Glu Phe Pro Ala Asp Ser Leu Gln Ala 
            660                 665                 670         


Ala Gln Pro Phe Thr Ile Gly Asp Asn Lys Thr Tyr Asn Gly Tyr Trp 
        675                 680                 685             


Asn Thr Pro Leu Leu Pro Tyr Lys Ser Tyr Arg Ile Tyr Phe Gln Ala 
    690                 695                 700                 


Ala Ser Arg Ala Asn Gly Glu Thr Lys Ile Asp Cys Val Gln Val Ala 
705                 710                 715                 720 


Thr Lys Gly Ala Ala Thr Pro Lys Pro Val Pro Glu Pro Glu Lys Gln 
                725                 730                 735     


Thr Asp His Thr Val Lys Ile Ala Gly Val Ile Ala Gly Ile Leu Leu 
            740                 745                 750         


Phe Val Ile Ile Phe Leu Gly Val Val Leu Val Met Lys Lys Arg Lys 
        755                 760                 765             


Leu Ala Lys Lys Arg Lys Glu Thr Met Ser Ser Thr Arg Gln Glu Met 
    770                 775                 780                 


Thr Val Met Val Asn Ser Met Asp Lys Ser Tyr Ala Glu Gln Gly Thr 
785                 790                 795                 800 


Asn Cys Asp Glu Ala Phe Ser Phe Met Asp Thr His Asn Leu Asn Gly 
                805                 810                 815     


Arg Ser Val Ser Ser Pro Ser Ser Phe Thr Met Lys Thr Asn Thr Leu 
            820                 825                 830         


Ser Thr Ser Val Pro Asn Ser Tyr Tyr Pro Asp Glu Thr His Thr Met 
        835                 840                 845             


Ala Ser Asp Thr Ser Ser Leu Val Gln Ser His Thr Tyr Lys Lys Arg 
    850                 855                 860                 


Glu Pro Ala Asp Val Pro Tyr Gln Thr Gly Gln Leu His Pro Ala Ile 
865                 870                 875                 880 


Arg Val Ala Asp Leu Leu Gln His Ile Thr Gln Met Lys Cys Ala Glu 
                885                 890                 895     


Gly Tyr Gly Phe Lys Glu Glu Tyr Glu Ser Phe Phe Glu Gly Gln Ser 
            900                 905                 910         


Ala Pro Trp Asp Ser Ala Lys Lys Asp Glu Asn Arg Met Lys Asn Arg 
        915                 920                 925             


Tyr Gly Asn Ile Ile Ala Tyr Asp His Ser Arg Val Arg Leu Gln Thr 
    930                 935                 940                 


Ile Glu Gly Asp Thr Asn Ser Asp Tyr Ile Asn Gly Asn Tyr Ile Asp 
945                 950                 955                 960 


Gly Tyr His Arg Pro Asn His Tyr Ile Ala Thr Gln Gly Pro Met Gln 
                965                 970                 975     


Glu Thr Ile Tyr Asp Phe Trp Arg Met Val Trp His Glu Asn Thr Ala 
            980                 985                 990         


Ser Ile Ile Met Val Thr Asn Leu  Val Glu Val Gly Arg  Val Lys Cys 
        995                 1000                 1005             


Cys Lys  Tyr Trp Pro Asp Asp  Thr Glu Ile Tyr Lys  Asp Ile Lys 
    1010                 1015                 1020             


Val Thr  Leu Ile Glu Thr Glu  Leu Leu Ala Glu Tyr  Val Ile Arg 
    1025                 1030                 1035             


Thr Phe  Ala Val Glu Lys Arg  Gly Val His Glu Ile  Arg Glu Ile 
    1040                 1045                 1050             


Arg Gln  Phe His Phe Thr Gly  Trp Pro Asp His Gly  Val Pro Tyr 
    1055                 1060                 1065             


His Ala  Thr Gly Leu Leu Gly  Phe Val Arg Gln Val  Lys Ser Lys 
    1070                 1075                 1080             


Ser Pro  Pro Ser Ala Gly Pro  Leu Val Val His Cys  Ser Ala Gly 
    1085                 1090                 1095             


Ala Gly  Arg Thr Gly Cys Phe  Ile Val Ile Asp Ile  Met Leu Asp 
    1100                 1105                 1110             


Met Ala  Glu Arg Glu Gly Val  Val Asp Ile Tyr Asn  Cys Val Arg 
    1115                 1120                 1125             


Glu Leu  Arg Ser Arg Arg Val  Asn Met Val Gln Thr  Glu Glu Gln 
    1130                 1135                 1140             


Tyr Val  Phe Ile His Asp Ala  Ile Leu Glu Ala Cys  Leu Cys Gly 
    1145                 1150                 1155             


Asp Thr  Ser Val Pro Ala Ser  Gln Val Arg Ser Leu  Tyr Tyr Asp 
    1160                 1165                 1170             


Met Asn  Lys Leu Asp Pro Gln  Thr Asn Ser Ser Gln  Ile Lys Glu 
    1175                 1180                 1185             


Glu Phe  Arg Thr Leu Asn Met  Val Thr Pro Thr Leu  Arg Val Glu 
    1190                 1195                 1200             


Asp Cys  Ser Ile Ala Leu Leu  Pro Arg Asn His Glu  Lys Asn Arg 
    1205                 1210                 1215             


Cys Met  Asp Ile Leu Pro Pro  Asp Arg Cys Leu Pro  Phe Leu Ile 
    1220                 1225                 1230             


Thr Ile  Asp Gly Glu Ser Ser  Asn Tyr Ile Asn Ala  Ala Leu Met 
    1235                 1240                 1245             


Asp Ser  Tyr Lys Gln Pro Ser  Ala Phe Ile Val Thr  Gln His Pro 
    1250                 1255                 1260             


Leu Pro  Asn Thr Val Lys Asp  Phe Trp Arg Leu Val  Leu Asp Tyr 
    1265                 1270                 1275             


His Cys  Thr Ser Val Val Met  Leu Asn Asp Val Asp  Pro Ala Gln 
    1280                 1285                 1290             


Leu Cys  Pro Gln Tyr Trp Pro  Glu Asn Gly Val His  Arg His Gly 
    1295                 1300                 1305             


Pro Ile  Gln Val Glu Phe Val  Ser Ala Asp Leu Glu  Glu Asp Ile 
    1310                 1315                 1320             


Ile Ser  Arg Ile Phe Arg Ile  Tyr Asn Ala Ala Arg  Pro Gln Asp 
    1325                 1330                 1335             


Gly Tyr  Arg Met Val Gln Gln  Phe Gln Phe Leu Gly  Trp Pro Met 
    1340                 1345                 1350             


Tyr Arg  Asp Thr Pro Val Ser  Lys Arg Ser Phe Leu  Lys Leu Ile 
    1355                 1360                 1365             


Arg Gln  Val Asp Lys Trp Gln  Glu Glu Tyr Asn Gly  Gly Glu Gly 
    1370                 1375                 1380             


Arg Thr  Val Val His Cys Leu  Asn Gly Gly Gly Arg  Ser Gly Thr 
    1385                 1390                 1395             


Phe Cys  Ala Ile Ser Ile Val  Cys Glu Met Leu Arg  His Gln Arg 
    1400                 1405                 1410             


Thr Val  Asp Val Phe His Ala  Val Lys Thr Leu Arg  Asn Asn Lys 
    1415                 1420                 1425             


Pro Asn  Met Val Asp Leu Leu  Asp Gln Tyr Lys Phe  Cys Tyr Glu 
    1430                 1435                 1440             


Val Ala  Leu Glu Tyr Leu Asn  Ser Gly 
    1445                 1450         


