                         SEQUENCE LISTING

<110>  Hopital Ste-Justine
       Moreau, Alain
       Akoume Ndong, Marie-Yvonne
 
<120>  GI PROTEIN PHOSPHORYLATION AS MARKER FOR SCOLIOSIS AND SCOLIOSIS 
       PROGRESSION, METHODS OF INCREASING GIPCR SIGNALING IN SCOLIOTIC 
       SUBJECTS

<130>  765/14033_122

<140>  N/A
<141>  2014-06-16

<150>  US 61/835,839
<151>  2013-06-17

<160>  100   

<170>  PatentIn version 3.5

<210>  1
<211>  23
<212>  DNA
<213>  ARTIFICIAL

<220>
<223>  Synthetic Construct

<400>  1
agggctatgg ggaggttgaa gat                                               23


<210>  2
<211>  22
<212>  DNA
<213>  ARTIFICIAL

<220>
<223>  Synthetic Construct

<400>  2
actccagcaa gttctgcagt ca                                                22


<210>  3
<211>  24
<212>  DNA
<213>  ARTIFICIAL

<220>
<223>  Synthetic Construct

<400>  3
agggaatacc agctcaacga ctca                                              24


<210>  4
<211>  24
<212>  DNA
<213>  ARTIFICIAL

<220>
<223>  Synthetic Construct

<400>  4
tgtgtgggga tgtagtcact ctgt                                              24


<210>  5
<211>  22
<212>  DNA
<213>  ARTIFICIAL

<220>
<223>  Synthetic Construct

<400>  5
gagagtgaag accacaggca tt                                                22


<210>  6
<211>  22
<212>  DNA
<213>  ARTIFICIAL

<220>
<223>  Synthetic Construct

<400>  6
cgttctgatc tttggccacc ta                                                22


<210>  7
<211>  22
<212>  DNA
<213>  ARTIFICIAL

<220>
<223>  Synthetic Construct

<400>  7
gagaccaagt tccaggtgga ca                                                22


<210>  8
<211>  20
<212>  DNA
<213>  ARTIFICIAL

<220>
<223>  Synthetic Construct

<400>  8
gatccacttg cggcgttcat                                                   20


<210>  9
<211>  20
<212>  DNA
<213>  ARTIFICIAL

<220>
<223>  Synthetic Construct

<400>  9
atcagaacat cttcacggcc                                                   20


<210>  10
<211>  20
<212>  DNA
<213>  ARTIFICIAL

<220>
<223>  Synthetic Construct

<400>  10
aaagcagaca ccttctccac                                                   20


<210>  11
<211>  22
<212>  DNA
<213>  ARTIFICIAL

<220>
<223>  Synthetic Construct

<400>  11
cggaatggat cacactgaga ag                                                22


<210>  12
<211>  21
<212>  DNA
<213>  ARTIFICIAL

<220>
<223>  Synthetic Construct

<400>  12
acataaggat ctgaaagccc g                                                 21


<210>  13
<211>  20
<212>  DNA
<213>  ARTIFICIAL

<220>
<223>  Synthetic Construct

<400>  13
ttcccgatcc caaaagtgag                                                   20


<210>  14
<211>  23
<212>  DNA
<213>  ARTIFICIAL

<220>
<223>  Synthetic Construct

<400>  14
gtcaaatccc aatcccaaat ctc                                               23


<210>  15
<211>  23
<212>  DNA
<213>  ARTIFICIAL

<220>
<223>  Synthetic Construct

<400>  15
gcttcaaggt tcacaactac atg                                               23


<210>  16
<211>  20
<212>  DNA
<213>  ARTIFICIAL

<220>
<223>  Synthetic Construct

<400>  16
accttctccc ggcatttatg                                                   20


<210>  17
<211>  20
<212>  DNA
<213>  ARTIFICIAL

<220>
<223>  Synthetic Construct

<400>  17
cctaccttct gcgatcactg                                                   20


<210>  18
<211>  20
<212>  DNA
<213>  ARTIFICIAL

<220>
<223>  Synthetic Construct

<400>  18
tactttggcg attcctctgg                                                   20


<210>  19
<211>  20
<212>  DNA
<213>  ARTIFICIAL

<220>
<223>  Synthetic Construct

<400>  19
gtaaatgcgg tggaacttgc                                                   20


<210>  20
<211>  20
<212>  DNA
<213>  ARTIFICIAL

<220>
<223>  Synthetic Construct

<400>  20
accccaatcc catttccttc                                                   20


<210>  21
<211>  21
<212>  DNA
<213>  ARTIFICIAL

<220>
<223>  Synthetic Construct

<400>  21
gagaagcatg tgtttgagca g                                                 21


<210>  22
<211>  21
<212>  DNA
<213>  ARTIFICIAL

<220>
<223>  Synthetic Construct

<400>  22
ggaagttttc tttgtcgctg c                                                 21


<210>  23
<211>  20
<212>  DNA
<213>  ARTIFICIAL

<220>
<223>  Synthetic Construct

<400>  23
acgaagtcaa gagccacaag                                                   20


<210>  24
<211>  20
<212>  DNA
<213>  ARTIFICIAL

<220>
<223>  Synthetic Construct

<400>  24
gtcgatgaac cacaaagctg                                                   20


<210>  25
<211>  21
<212>  DNA
<213>  ARTIFICIAL

<220>
<223>  Synthetic Construct

<400>  25
cggattttgg aatgtgcaag g                                                 21


<210>  26
<211>  21
<212>  DNA
<213>  ARTIFICIAL

<220>
<223>  Synthetic Construct

<400>  26
cataaaggag aaccccgaag g                                                 21


<210>  27
<211>  21
<212>  DNA
<213>  ARTIFICIAL

<220>
<223>  Synthetic Construct

<400>  27
tgcttacatt tcctcatccc g                                                 21


<210>  28
<211>  20
<212>  DNA
<213>  ARTIFICIAL

<220>
<223>  Synthetic Construct

<400>  28
cgcccgatga ctctgattag                                                   20


<210>  29
<211>  20
<212>  DNA
<213>  ARTIFICIAL

<220>
<223>  Synthetic Construct

<400>  29
aatggagggc aaaggagatg                                                   20


<210>  30
<211>  21
<212>  DNA
<213>  ARTIFICIAL

<220>
<223>  Synthetic Construct

<400>  30
aagatgtagg caatcactcc g                                                 21


<210>  31
<211>  21
<212>  DNA
<213>  ARTIFICIAL

<220>
<223>  Synthetic Construct

<400>  31
cttgagaagg atccgaacga g                                                 21


<210>  32
<211>  20
<212>  DNA
<213>  ARTIFICIAL

<220>
<223>  Synthetic Construct

<400>  32
ttgcctccac ttgctcttag                                                   20


<210>  33
<211>  22
<212>  DNA
<213>  ARTIFICIAL

<220>
<223>  Synthetic Construct

<400>  33
cagttccagc gttcagttaa tg                                                22


<210>  34
<211>  23
<212>  DNA
<213>  ARTIFICIAL

<220>
<223>  Synthetic Construct

<400>  34
ttcgtgtagg actcaaaatc tcc                                               23


<210>  35
<211>  22
<212>  DNA
<213>  ARTIFICIAL

<220>
<223>  Synthetic Construct

<400>  35
ctctgacatc ctgaactctg tg                                                22


<210>  36
<211>  22
<212>  DNA
<213>  ARTIFICIAL

<220>
<223>  Synthetic Construct

<400>  36
ccgtggtctt aatgatctcc tg                                                22


<210>  37
<211>  22
<212>  DNA
<213>  ARTIFICIAL

<220>
<223>  Synthetic Construct

<400>  37
ggcacacctg gatatctttc tc                                                22


<210>  38
<211>  21
<212>  DNA
<213>  ARTIFICIAL

<220>
<223>  Synthetic Construct

<400>  38
agtctgtgtt ggtcttcatc c                                                 21


<210>  39
<211>  20
<212>  DNA
<213>  ARTIFICIAL

<220>
<223>  Synthetic Construct

<400>  39
aaacagtctc gtaagcccag                                                   20


<210>  40
<211>  20
<212>  DNA
<213>  ARTIFICIAL

<220>
<223>  Synthetic Construct

<400>  40
atcccatctg tagcgttgtg                                                   20


<210>  41
<211>  19
<212>  DNA
<213>  ARTIFICIAL

<220>
<223>  Synthetic Construct

<400>  41
tcgcctctca catccaaac                                                    19


<210>  42
<211>  23
<212>  DNA
<213>  ARTIFICIAL

<220>
<223>  Synthetic Construct

<400>  42
catctcgctc actgtaatat ccc                                               23


<210>  43
<211>  21
<212>  DNA
<213>  ARTIFICIAL

<220>
<223>  Synthetic Construct

<400>  43
aggacaccaa caacttcttc g                                                 21


<210>  44
<211>  20
<212>  DNA
<213>  ARTIFICIAL

<220>
<223>  Synthetic Construct

<400>  44
ggtgccttgt cggtcatatt                                                   20


<210>  45
<211>  22
<212>  DNA
<213>  ARTIFICIAL

<220>
<223>  Synthetic Construct

<400>  45
ctcagttcct ggagaaagat gg                                                22


<210>  46
<211>  21
<212>  DNA
<213>  ARTIFICIAL

<220>
<223>  Synthetic Construct

<400>  46
cccagtcaat tcatgtttgc c                                                 21


<210>  47
<211>  22
<212>  DNA
<213>  ARTIFICIAL

<220>
<223>  Synthetic Construct

<400>  47
atggaatatg tgtctggagg tg                                                22


<210>  48
<211>  21
<212>  DNA
<213>  ARTIFICIAL

<220>
<223>  Synthetic Construct

<400>  48
tggtttcagg tctcgatgaa c                                                 21


<210>  49
<211>  21
<212>  DNA
<213>  ARTIFICIAL

<220>
<223>  Synthetic Construct

<400>  49
gagtaaactt cccctcacca g                                                 21


<210>  50
<211>  20
<212>  DNA
<213>  ARTIFICIAL

<220>
<223>  Synthetic Construct

<400>  50
tccactgacc atccacaaag                                                   20


<210>  51
<211>  20
<212>  DNA
<213>  ARTIFICIAL

<220>
<223>  Synthetic Construct

<400>  51
cactgttatc cgctggtctg                                                   20


<210>  52
<211>  21
<212>  DNA
<213>  ARTIFICIAL

<220>
<223>  Synthetic Construct

<400>  52
cttgtattgg tgctctccct c                                                 21


<210>  53
<211>  26
<212>  DNA
<213>  ARTIFICIAL

<220>
<223>  Synthetic Construct

<400>  53
caaggacaac tcaaacttat acatgg                                            26


<210>  54
<211>  22
<212>  DNA
<213>  ARTIFICIAL

<220>
<223>  Synthetic Construct

<400>  54
cagatactca aaggtcagga cg                                                22


<210>  55
<211>  21
<212>  DNA
<213>  ARTIFICIAL

<220>
<223>  Synthetic Construct

<400>  55
cctttccttg ttcgactgga g                                                 21


<210>  56
<211>  19
<212>  DNA
<213>  ARTIFICIAL

<220>
<223>  Synthetic Construct

<400>  56
tgagctgcat agaaccgtg                                                    19


<210>  57
<211>  22
<212>  DNA
<213>  ARTIFICIAL

<220>
<223>  Synthetic Construct

<400>  57
ccggatctcc atcaatgaga ag                                                22


<210>  58
<211>  20
<212>  DNA
<213>  ARTIFICIAL

<220>
<223>  Synthetic Construct

<400>  58
ttcaatccaa ccctcccatc                                                   20


<210>  59
<211>  20
<212>  DNA
<213>  ARTIFICIAL

<220>
<223>  Synthetic Construct

<400>  59
gcgcattctg aagttcctca                                                   20


<210>  60
<211>  21
<212>  DNA
<213>  ARTIFICIAL

<220>
<223>  Synthetic Construct

<400>  60
aaaatcccca gagccacata g                                                 21


<210>  61
<211>  21
<212>  DNA
<213>  ARTIFICIAL

<220>
<223>  Synthetic Construct

<400>  61
ttgcccgtta ttgaccctat c                                                 21


<210>  62
<211>  22
<212>  DNA
<213>  ARTIFICIAL

<220>
<223>  Synthetic Construct

<400>  62
cgttcctatt ccaagctcat cc                                                22


<210>  63
<211>  21
<212>  DNA
<213>  ARTIFICIAL

<220>
<223>  Synthetic Construct

<400>  63
tgactgcact ggacatcttt g                                                 21


<210>  64
<211>  19
<212>  DNA
<213>  ARTIFICIAL

<220>
<223>  Synthetic Construct

<400>  64
tggttgtagg tttgctggg                                                    19


<210>  65
<211>  23
<212>  DNA
<213>  ARTIFICIAL

<220>
<223>  Synthetic Construct

<400>  65
tgtcggaggg aaatataaac tgg                                               23


<210>  66
<211>  22
<212>  DNA
<213>  ARTIFICIAL

<220>
<223>  Synthetic Construct

<400>  66
ggccttctga gattctagct tc                                                22


<210>  67
<211>  18
<212>  DNA
<213>  ARTIFICIAL

<220>
<223>  Synthetic Construct

<400>  67
aggtggaggt agtggagg                                                     18


<210>  68
<211>  22
<212>  DNA
<213>  ARTIFICIAL

<220>
<223>  Synthetic Construct

<400>  68
gtacaattga gtcagagtcc cc                                                22


<210>  69
<211>  21
<212>  DNA
<213>  ARTIFICIAL

<220>
<223>  Synthetic Construct

<400>  69
gtgatgttct agccacagag g                                                 21


<210>  70
<211>  21
<212>  DNA
<213>  ARTIFICIAL

<220>
<223>  Synthetic Construct

<400>  70
ccctttccct cctttcttgt c                                                 21


<210>  71
<211>  21
<212>  DNA
<213>  ARTIFICIAL

<220>
<223>  Synthetic Construct

<400>  71
gttcaaatgc acccatcaca g                                                 21


<210>  72
<211>  21
<212>  DNA
<213>  ARTIFICIAL

<220>
<223>  Synthetic Construct

<400>  72
agtaactccc caggatctgt c                                                 21


<210>  73
<211>  22
<212>  DNA
<213>  ARTIFICIAL

<220>
<223>  Synthetic Construct

<400>  73
gtatgagatt ctgaaggccc tg                                                22


<210>  74
<211>  22
<212>  DNA
<213>  ARTIFICIAL

<220>
<223>  Synthetic Construct

<400>  74
ccaaacccca gtctattagt cg                                                22


<210>  75
<211>  22
<212>  DNA
<213>  ARTIFICIAL

<220>
<223>  Synthetic Construct

<400>  75
cgatacgacc atcaacagag ac                                                22


<210>  76
<211>  20
<212>  DNA
<213>  ARTIFICIAL

<220>
<223>  Synthetic Construct

<400>  76
tcgctttcca gtcttcatcg                                                   20


<210>  77
<211>  1065
<212>  DNA
<213>  Homo sapiens

<400>  77
atgggctgca cgctgagcgc cgaggacaag gcggcggtgg agcggagtaa gatgatcgac       60

cgcaacctcc gtgaggacgg cgagaaggcg gcgcgcgagg tcaagctgct gctgctcggt      120

gctggtgaat ctggtaaaag tacaattgtg aagcagatga aaattatcca tgaagctggt      180

tattcagaag aggagtgtaa acaatacaaa gcagtggtct acagtaacac catccagtca      240

attattgcta tcattagggc tatggggagg ttgaagatag actttggtga ctcagcccgg      300

gcggatgatg cacgccaact ctttgtgcta gctggagctg ctgaagaagg ctttatgact      360

gcagaacttg ctggagttat aaagagattg tggaaagata gtggtgtaca agcctgtttc      420

aacagatccc gagagtacca gcttaatgat tctgcagcat actatttgaa tgacttggac      480

agaatagctc aaccaaatta catcccgact caacaagatg ttctcagaac tagagtgaaa      540

actacaggaa ttgttgaaac ccattttact ttcaaagatc ttcattttaa aatgtttgat      600

gtgggaggtc agagatctga gcggaagaag tggattcatt gcttcgaagg agtgacggcg      660

atcatcttct gtgtagcact gagtgactac gacctggttc tagctgaaga tgaagaaatg      720

aaccgaatgc atgaaagcat gaaattgttt gacagcatat gtaacaacaa gtggtttaca      780

gatacatcca ttatactttt tctaaacaag aaggatctct ttgaagaaaa aatcaaaaag      840

agccctctca ctatatgcta tccagaatat gcaggatcaa acacatatga agaggcagct      900

gcatatattc aatgtcagtt tgaagacctc aataaaagaa aggacacaaa ggaaatatac      960

acccacttca catgtgccac agatactaag aatgtgcagt ttgtttttga tgctgtaaca     1020

gatgtcatca taaaaaataa tctaaaagat tgtggtctct tttaa                     1065


<210>  78
<211>  354
<212>  PRT
<213>  Homo sapiens

<400>  78

Met Gly Cys Thr Leu Ser Ala Glu Asp Lys Ala Ala Val Glu Arg Ser 
1               5                   10                  15      


Lys Met Ile Asp Arg Asn Leu Arg Glu Asp Gly Glu Lys Ala Ala Arg 
            20                  25                  30          


Glu Val Lys Leu Leu Leu Leu Gly Ala Gly Glu Ser Gly Lys Ser Thr 
        35                  40                  45              


Ile Val Lys Gln Met Lys Ile Ile His Glu Ala Gly Tyr Ser Glu Glu 
    50                  55                  60                  


Glu Cys Lys Gln Tyr Lys Ala Val Val Tyr Ser Asn Thr Ile Gln Ser 
65                  70                  75                  80  


Ile Ile Ala Ile Ile Arg Ala Met Gly Arg Leu Lys Ile Asp Phe Gly 
                85                  90                  95      


Asp Ser Ala Arg Ala Asp Asp Ala Arg Gln Leu Phe Val Leu Ala Gly 
            100                 105                 110         


Ala Ala Glu Glu Gly Phe Met Thr Ala Glu Leu Ala Gly Val Ile Lys 
        115                 120                 125             


Arg Leu Trp Lys Asp Ser Gly Val Gln Ala Cys Phe Asn Arg Ser Arg 
    130                 135                 140                 


Glu Tyr Gln Leu Asn Asp Ser Ala Ala Tyr Tyr Leu Asn Asp Leu Asp 
145                 150                 155                 160 


Arg Ile Ala Gln Pro Asn Tyr Ile Pro Thr Gln Gln Asp Val Leu Arg 
                165                 170                 175     


Thr Arg Val Lys Thr Thr Gly Ile Val Glu Thr His Phe Thr Phe Lys 
            180                 185                 190         


Asp Leu His Phe Lys Met Phe Asp Val Gly Gly Gln Arg Ser Glu Arg 
        195                 200                 205             


Lys Lys Trp Ile His Cys Phe Glu Gly Val Thr Ala Ile Ile Phe Cys 
    210                 215                 220                 


Val Ala Leu Ser Asp Tyr Asp Leu Val Leu Ala Glu Asp Glu Glu Met 
225                 230                 235                 240 


Asn Arg Met His Glu Ser Met Lys Leu Phe Asp Ser Ile Cys Asn Asn 
                245                 250                 255     


Lys Trp Phe Thr Asp Thr Ser Ile Ile Leu Phe Leu Asn Lys Lys Asp 
            260                 265                 270         


Leu Phe Glu Glu Lys Ile Lys Lys Ser Pro Leu Thr Ile Cys Tyr Pro 
        275                 280                 285             


Glu Tyr Ala Gly Ser Asn Thr Tyr Glu Glu Ala Ala Ala Tyr Ile Gln 
    290                 295                 300                 


Cys Gln Phe Glu Asp Leu Asn Lys Arg Lys Asp Thr Lys Glu Ile Tyr 
305                 310                 315                 320 


Thr His Phe Thr Cys Ala Thr Asp Thr Lys Asn Val Gln Phe Val Phe 
                325                 330                 335     


Asp Ala Val Thr Asp Val Ile Ile Lys Asn Asn Leu Lys Asp Cys Gly 
            340                 345                 350         


Leu Phe 
        


<210>  79
<211>  909
<212>  DNA
<213>  Homo sapiens

<400>  79
atgaaaatta tccatgaagc tggttattca gaagaggagt gtaaacaata caaagcagtg       60

gtctacagta acaccatcca gtcaattatt gctatcatta gggctatggg gaggttgaag      120

atagactttg gtgactcagc ccgggcggat gatgcacgcc aactctttgt gctagctgga      180

gctgctgaag aaggctttat gactgcagaa cttgctggag ttataaagag attgtggaaa      240

gatagtggtg tacaagcctg tttcaacaga tcccgagagt accagcttaa tgattctgca      300

gcatactatt tgaatgactt ggacagaata gctcaaccaa attacatccc gactcaacaa      360

gatgttctca gaactagagt gaaaactaca ggaattgttg aaacccattt tactttcaaa      420

gatcttcatt ttaaaatgtt tgatgtggga ggtcagagat ctgagcggaa gaagtggatt      480

cattgcttcg aaggagtgac ggcgatcatc ttctgtgtag cactgagtga ctacgacctg      540

gttctagctg aagatgaaga aatgaaccga atgcatgaaa gcatgaaatt gtttgacagc      600

atatgtaaca acaagtggtt tacagataca tccattatac tttttctaaa caagaaggat      660

ctctttgaag aaaaaatcaa aaagagccct ctcactatat gctatccaga atatgcagga      720

tcaaacacat atgaagaggc agctgcatat attcaatgtc agtttgaaga cctcaataaa      780

agaaaggaca caaaggaaat atacacccac ttcacatgtg ccacagatac taagaatgtg      840

cagtttgttt ttgatgctgt aacagatgtc atcataaaaa ataatctaaa agattgtggt      900

ctcttttaa                                                              909


<210>  80
<211>  302
<212>  PRT
<213>  Homo sapiens

<400>  80

Met Lys Ile Ile His Glu Ala Gly Tyr Ser Glu Glu Glu Cys Lys Gln 
1               5                   10                  15      


Tyr Lys Ala Val Val Tyr Ser Asn Thr Ile Gln Ser Ile Ile Ala Ile 
            20                  25                  30          


Ile Arg Ala Met Gly Arg Leu Lys Ile Asp Phe Gly Asp Ser Ala Arg 
        35                  40                  45              


Ala Asp Asp Ala Arg Gln Leu Phe Val Leu Ala Gly Ala Ala Glu Glu 
    50                  55                  60                  


Gly Phe Met Thr Ala Glu Leu Ala Gly Val Ile Lys Arg Leu Trp Lys 
65                  70                  75                  80  


Asp Ser Gly Val Gln Ala Cys Phe Asn Arg Ser Arg Glu Tyr Gln Leu 
                85                  90                  95      


Asn Asp Ser Ala Ala Tyr Tyr Leu Asn Asp Leu Asp Arg Ile Ala Gln 
            100                 105                 110         


Pro Asn Tyr Ile Pro Thr Gln Gln Asp Val Leu Arg Thr Arg Val Lys 
        115                 120                 125             


Thr Thr Gly Ile Val Glu Thr His Phe Thr Phe Lys Asp Leu His Phe 
    130                 135                 140                 


Lys Met Phe Asp Val Gly Gly Gln Arg Ser Glu Arg Lys Lys Trp Ile 
145                 150                 155                 160 


His Cys Phe Glu Gly Val Thr Ala Ile Ile Phe Cys Val Ala Leu Ser 
                165                 170                 175     


Asp Tyr Asp Leu Val Leu Ala Glu Asp Glu Glu Met Asn Arg Met His 
            180                 185                 190         


Glu Ser Met Lys Leu Phe Asp Ser Ile Cys Asn Asn Lys Trp Phe Thr 
        195                 200                 205             


Asp Thr Ser Ile Ile Leu Phe Leu Asn Lys Lys Asp Leu Phe Glu Glu 
    210                 215                 220                 


Lys Ile Lys Lys Ser Pro Leu Thr Ile Cys Tyr Pro Glu Tyr Ala Gly 
225                 230                 235                 240 


Ser Asn Thr Tyr Glu Glu Ala Ala Ala Tyr Ile Gln Cys Gln Phe Glu 
                245                 250                 255     


Asp Leu Asn Lys Arg Lys Asp Thr Lys Glu Ile Tyr Thr His Phe Thr 
            260                 265                 270         


Cys Ala Thr Asp Thr Lys Asn Val Gln Phe Val Phe Asp Ala Val Thr 
        275                 280                 285             


Asp Val Ile Ile Lys Asn Asn Leu Lys Asp Cys Gly Leu Phe 
    290                 295                 300         


<210>  81
<211>  1068
<212>  DNA
<213>  Homo sapiens

<400>  81
atgggctgca ccgtgagcgc cgaggacaag gcggcggccg agcgctctaa gatgatcgac       60

aagaacctgc gggaggacgg agagaaggcg gcgcgggagg tgaagttgct gctgttgggt      120

gctggggagt cagggaagag caccatcgtc aagcagatga agatcatcca cgaggatggc      180

tactccgagg aggaatgccg gcagtaccgg gcggttgtct acagcaacac catccagtcc      240

atcatggcca ttgtcaaagc catgggcaac ctgcagatcg actttgccga cccctccaga      300

gcggacgacg ccaggcagct atttgcactg tcctgcaccg ccgaggagca aggcgtgctc      360

cctgatgacc tgtccggcgt catccggagg ctctgggctg accatggtgt gcaggcctgc      420

tttggccgct caagggaata ccagctcaac gactcagctg cctactacct gaacgacctg      480

gagcgtattg cacagagtga ctacatcccc acacagcaag atgtgctacg gacccgcgta      540

aagaccacgg ggatcgtgga gacacacttc accttcaagg acctacactt caagatgttt      600

gatgtgggtg gtcagcggtc tgagcggaag aagtggatcc actgctttga gggcgtcaca      660

gccatcatct tctgcgtagc cttgagcgcc tatgacttgg tgctagctga ggacgaggag      720

atgaaccgca tgcatgagag catgaagcta ttcgatagca tctgcaacaa caagtggttc      780

acagacacgt ccatcatcct cttcctcaac aagaaggacc tgtttgagga gaagatcaca      840

cacagtcccc tgaccatctg cttccctgag tacacagggg ccaacaaata tgatgaggca      900

gccagctaca tccagagtaa gtttgaggac ctgaataagc gcaaagacac caaggagatc      960

tacacgcact tcacgtgcgc caccgacacc aagaacgtgc agttcgtgtt tgacgccgtc     1020

accgatgtca tcatcaagaa caacctgaag gactgcggcc tcttctga                  1068


<210>  82
<211>  355
<212>  PRT
<213>  Homo sapiens

<400>  82

Met Gly Cys Thr Val Ser Ala Glu Asp Lys Ala Ala Ala Glu Arg Ser 
1               5                   10                  15      


Lys Met Ile Asp Lys Asn Leu Arg Glu Asp Gly Glu Lys Ala Ala Arg 
            20                  25                  30          


Glu Val Lys Leu Leu Leu Leu Gly Ala Gly Glu Ser Gly Lys Ser Thr 
        35                  40                  45              


Ile Val Lys Gln Met Lys Ile Ile His Glu Asp Gly Tyr Ser Glu Glu 
    50                  55                  60                  


Glu Cys Arg Gln Tyr Arg Ala Val Val Tyr Ser Asn Thr Ile Gln Ser 
65                  70                  75                  80  


Ile Met Ala Ile Val Lys Ala Met Gly Asn Leu Gln Ile Asp Phe Ala 
                85                  90                  95      


Asp Pro Ser Arg Ala Asp Asp Ala Arg Gln Leu Phe Ala Leu Ser Cys 
            100                 105                 110         


Thr Ala Glu Glu Gln Gly Val Leu Pro Asp Asp Leu Ser Gly Val Ile 
        115                 120                 125             


Arg Arg Leu Trp Ala Asp His Gly Val Gln Ala Cys Phe Gly Arg Ser 
    130                 135                 140                 


Arg Glu Tyr Gln Leu Asn Asp Ser Ala Ala Tyr Tyr Leu Asn Asp Leu 
145                 150                 155                 160 


Glu Arg Ile Ala Gln Ser Asp Tyr Ile Pro Thr Gln Gln Asp Val Leu 
                165                 170                 175     


Arg Thr Arg Val Lys Thr Thr Gly Ile Val Glu Thr His Phe Thr Phe 
            180                 185                 190         


Lys Asp Leu His Phe Lys Met Phe Asp Val Gly Gly Gln Arg Ser Glu 
        195                 200                 205             


Arg Lys Lys Trp Ile His Cys Phe Glu Gly Val Thr Ala Ile Ile Phe 
    210                 215                 220                 


Cys Val Ala Leu Ser Ala Tyr Asp Leu Val Leu Ala Glu Asp Glu Glu 
225                 230                 235                 240 


Met Asn Arg Met His Glu Ser Met Lys Leu Phe Asp Ser Ile Cys Asn 
                245                 250                 255     


Asn Lys Trp Phe Thr Asp Thr Ser Ile Ile Leu Phe Leu Asn Lys Lys 
            260                 265                 270         


Asp Leu Phe Glu Glu Lys Ile Thr His Ser Pro Leu Thr Ile Cys Phe 
        275                 280                 285             


Pro Glu Tyr Thr Gly Ala Asn Lys Tyr Asp Glu Ala Ala Ser Tyr Ile 
    290                 295                 300                 


Gln Ser Lys Phe Glu Asp Leu Asn Lys Arg Lys Asp Thr Lys Glu Ile 
305                 310                 315                 320 


Tyr Thr His Phe Thr Cys Ala Thr Asp Thr Lys Asn Val Gln Phe Val 
                325                 330                 335     


Phe Asp Ala Val Thr Asp Val Ile Ile Lys Asn Asn Leu Lys Asp Cys 
            340                 345                 350         


Gly Leu Phe 
        355 


<210>  83
<211>  957
<212>  DNA
<213>  Homo sapiens

<400>  83
atgagaggtg ctggggagtc agggaagagc accatcgtca agcagatgaa gatcatccac       60

gaggatggct actccgagga ggaatgccgg cagtaccggg cggttgtcta cagcaacacc      120

atccagtcca tcatggccat tgtcaaagcc atgggcaacc tgcagatcga ctttgccgac      180

ccctccagag cggacgacgc caggcagcta tttgcactgt cctgcaccgc cgaggagcaa      240

ggcgtgctcc ctgatgacct gtccggcgtc atccggaggc tctgggctga ccatggtgtg      300

caggcctgct ttggccgctc aagggaatac cagctcaacg actcagctgc ctactacctg      360

aacgacctgg agcgtattgc acagagtgac tacatcccca cacagcaaga tgtgctacgg      420

acccgcgtaa agaccacggg gatcgtggag acacacttca ccttcaagga cctacacttc      480

aagatgtttg atgtgggtgg tcagcggtct gagcggaaga agtggatcca ctgctttgag      540

ggcgtcacag ccatcatctt ctgcgtagcc ttgagcgcct atgacttggt gctagctgag      600

gacgaggaga tgaaccgcat gcatgagagc atgaagctat tcgatagcat ctgcaacaac      660

aagtggttca cagacacgtc catcatcctc ttcctcaaca agaaggacct gtttgaggag      720

aagatcacac acagtcccct gaccatctgc ttccctgagt acacaggggc caacaaatat      780

gatgaggcag ccagctacat ccagagtaag tttgaggacc tgaataagcg caaagacacc      840

aaggagatct acacgcactt cacgtgcgcc accgacacca agaacgtgca gttcgtgttt      900

gacgccgtca ccgatgtcat catcaagaac aacctgaagg actgcggcct cttctga         957


<210>  84
<211>  318
<212>  PRT
<213>  Homo sapiens

<400>  84

Met Arg Gly Ala Gly Glu Ser Gly Lys Ser Thr Ile Val Lys Gln Met 
1               5                   10                  15      


Lys Ile Ile His Glu Asp Gly Tyr Ser Glu Glu Glu Cys Arg Gln Tyr 
            20                  25                  30          


Arg Ala Val Val Tyr Ser Asn Thr Ile Gln Ser Ile Met Ala Ile Val 
        35                  40                  45              


Lys Ala Met Gly Asn Leu Gln Ile Asp Phe Ala Asp Pro Ser Arg Ala 
    50                  55                  60                  


Asp Asp Ala Arg Gln Leu Phe Ala Leu Ser Cys Thr Ala Glu Glu Gln 
65                  70                  75                  80  


Gly Val Leu Pro Asp Asp Leu Ser Gly Val Ile Arg Arg Leu Trp Ala 
                85                  90                  95      


Asp His Gly Val Gln Ala Cys Phe Gly Arg Ser Arg Glu Tyr Gln Leu 
            100                 105                 110         


Asn Asp Ser Ala Ala Tyr Tyr Leu Asn Asp Leu Glu Arg Ile Ala Gln 
        115                 120                 125             


Ser Asp Tyr Ile Pro Thr Gln Gln Asp Val Leu Arg Thr Arg Val Lys 
    130                 135                 140                 


Thr Thr Gly Ile Val Glu Thr His Phe Thr Phe Lys Asp Leu His Phe 
145                 150                 155                 160 


Lys Met Phe Asp Val Gly Gly Gln Arg Ser Glu Arg Lys Lys Trp Ile 
                165                 170                 175     


His Cys Phe Glu Gly Val Thr Ala Ile Ile Phe Cys Val Ala Leu Ser 
            180                 185                 190         


Ala Tyr Asp Leu Val Leu Ala Glu Asp Glu Glu Met Asn Arg Met His 
        195                 200                 205             


Glu Ser Met Lys Leu Phe Asp Ser Ile Cys Asn Asn Lys Trp Phe Thr 
    210                 215                 220                 


Asp Thr Ser Ile Ile Leu Phe Leu Asn Lys Lys Asp Leu Phe Glu Glu 
225                 230                 235                 240 


Lys Ile Thr His Ser Pro Leu Thr Ile Cys Phe Pro Glu Tyr Thr Gly 
                245                 250                 255     


Ala Asn Lys Tyr Asp Glu Ala Ala Ser Tyr Ile Gln Ser Lys Phe Glu 
            260                 265                 270         


Asp Leu Asn Lys Arg Lys Asp Thr Lys Glu Ile Tyr Thr His Phe Thr 
        275                 280                 285             


Cys Ala Thr Asp Thr Lys Asn Val Gln Phe Val Phe Asp Ala Val Thr 
    290                 295                 300                 


Asp Val Ile Ile Lys Asn Asn Leu Lys Asp Cys Gly Leu Phe 
305                 310                 315             


<210>  85
<211>  912
<212>  DNA
<213>  Homo sapiens

<400>  85
atgaagatca tccacgagga tggctactcc gaggaggaat gccggcagta ccgggcggtt       60

gtctacagca acaccatcca gtccatcatg gccattgtca aagccatggg caacctgcag      120

atcgactttg ccgacccctc cagagcggac gacgccaggc agctatttgc actgtcctgc      180

accgccgagg agcaaggcgt gctccctgat gacctgtccg gcgtcatccg gaggctctgg      240

gctgaccatg gtgtgcaggc ctgctttggc cgctcaaggg aataccagct caacgactca      300

gctgcctact acctgaacga cctggagcgt attgcacaga gtgactacat ccccacacag      360

caagatgtgc tacggacccg cgtaaagacc acggggatcg tggagacaca cttcaccttc      420

aaggacctac acttcaagat gtttgatgtg ggtggtcagc ggtctgagcg gaagaagtgg      480

atccactgct ttgagggcgt cacagccatc atcttctgcg tagccttgag cgcctatgac      540

ttggtgctag ctgaggacga ggagatgaac cgcatgcatg agagcatgaa gctattcgat      600

agcatctgca acaacaagtg gttcacagac acgtccatca tcctcttcct caacaagaag      660

gacctgtttg aggagaagat cacacacagt cccctgacca tctgcttccc tgagtacaca      720

ggggccaaca aatatgatga ggcagccagc tacatccaga gtaagtttga ggacctgaat      780

aagcgcaaag acaccaagga gatctacacg cacttcacgt gcgccaccga caccaagaac      840

gtgcagttcg tgtttgacgc cgtcaccgat gtcatcatca agaacaacct gaaggactgc      900

ggcctcttct ga                                                          912


<210>  86
<211>  303
<212>  PRT
<213>  Homo sapiens

<400>  86

Met Lys Ile Ile His Glu Asp Gly Tyr Ser Glu Glu Glu Cys Arg Gln 
1               5                   10                  15      


Tyr Arg Ala Val Val Tyr Ser Asn Thr Ile Gln Ser Ile Met Ala Ile 
            20                  25                  30          


Val Lys Ala Met Gly Asn Leu Gln Ile Asp Phe Ala Asp Pro Ser Arg 
        35                  40                  45              


Ala Asp Asp Ala Arg Gln Leu Phe Ala Leu Ser Cys Thr Ala Glu Glu 
    50                  55                  60                  


Gln Gly Val Leu Pro Asp Asp Leu Ser Gly Val Ile Arg Arg Leu Trp 
65                  70                  75                  80  


Ala Asp His Gly Val Gln Ala Cys Phe Gly Arg Ser Arg Glu Tyr Gln 
                85                  90                  95      


Leu Asn Asp Ser Ala Ala Tyr Tyr Leu Asn Asp Leu Glu Arg Ile Ala 
            100                 105                 110         


Gln Ser Asp Tyr Ile Pro Thr Gln Gln Asp Val Leu Arg Thr Arg Val 
        115                 120                 125             


Lys Thr Thr Gly Ile Val Glu Thr His Phe Thr Phe Lys Asp Leu His 
    130                 135                 140                 


Phe Lys Met Phe Asp Val Gly Gly Gln Arg Ser Glu Arg Lys Lys Trp 
145                 150                 155                 160 


Ile His Cys Phe Glu Gly Val Thr Ala Ile Ile Phe Cys Val Ala Leu 
                165                 170                 175     


Ser Ala Tyr Asp Leu Val Leu Ala Glu Asp Glu Glu Met Asn Arg Met 
            180                 185                 190         


His Glu Ser Met Lys Leu Phe Asp Ser Ile Cys Asn Asn Lys Trp Phe 
        195                 200                 205             


Thr Asp Thr Ser Ile Ile Leu Phe Leu Asn Lys Lys Asp Leu Phe Glu 
    210                 215                 220                 


Glu Lys Ile Thr His Ser Pro Leu Thr Ile Cys Phe Pro Glu Tyr Thr 
225                 230                 235                 240 


Gly Ala Asn Lys Tyr Asp Glu Ala Ala Ser Tyr Ile Gln Ser Lys Phe 
                245                 250                 255     


Glu Asp Leu Asn Lys Arg Lys Asp Thr Lys Glu Ile Tyr Thr His Phe 
            260                 265                 270         


Thr Cys Ala Thr Asp Thr Lys Asn Val Gln Phe Val Phe Asp Ala Val 
        275                 280                 285             


Thr Asp Val Ile Ile Lys Asn Asn Leu Lys Asp Cys Gly Leu Phe 
    290                 295                 300             


<210>  87
<211>  825
<212>  DNA
<213>  Homo sapiens

<400>  87
atggccattg tcaaagccat gggcaacctg cagatcgact ttgccgaccc ctccagagcg       60

gacgacgcca ggcagctatt tgcactgtcc tgcaccgccg aggagcaagg cgtgctccct      120

gatgacctgt ccggcgtcat ccggaggctc tgggctgacc atggtgtgca ggcctgcttt      180

ggccgctcaa gggaatacca gctcaacgac tcagctgcct actacctgaa cgacctggag      240

cgtattgcac agagtgacta catccccaca cagcaagatg tgctacggac ccgcgtaaag      300

accacgggga tcgtggagac acacttcacc ttcaaggacc tacacttcaa gatgtttgat      360

gtgggtggtc agcggtctga gcggaagaag tggatccact gctttgaggg cgtcacagcc      420

atcatcttct gcgtagcctt gagcgcctat gacttggtgc tagctgagga cgaggagatg      480

aaccgcatgc atgagagcat gaagctattc gatagcatct gcaacaacaa gtggttcaca      540

gacacgtcca tcatcctctt cctcaacaag aaggacctgt ttgaggagaa gatcacacac      600

agtcccctga ccatctgctt ccctgagtac acaggggcca acaaatatga tgaggcagcc      660

agctacatcc agagtaagtt tgaggacctg aataagcgca aagacaccaa ggagatctac      720

acgcacttca cgtgcgccac cgacaccaag aacgtgcagt tcgtgtttga cgccgtcacc      780

gatgtcatca tcaagaacaa cctgaaggac tgcggcctct tctga                      825


<210>  88
<211>  274
<212>  PRT
<213>  Homo sapiens

<400>  88

Met Ala Ile Val Lys Ala Met Gly Asn Leu Gln Ile Asp Phe Ala Asp 
1               5                   10                  15      


Pro Ser Arg Ala Asp Asp Ala Arg Gln Leu Phe Ala Leu Ser Cys Thr 
            20                  25                  30          


Ala Glu Glu Gln Gly Val Leu Pro Asp Asp Leu Ser Gly Val Ile Arg 
        35                  40                  45              


Arg Leu Trp Ala Asp His Gly Val Gln Ala Cys Phe Gly Arg Ser Arg 
    50                  55                  60                  


Glu Tyr Gln Leu Asn Asp Ser Ala Ala Tyr Tyr Leu Asn Asp Leu Glu 
65                  70                  75                  80  


Arg Ile Ala Gln Ser Asp Tyr Ile Pro Thr Gln Gln Asp Val Leu Arg 
                85                  90                  95      


Thr Arg Val Lys Thr Thr Gly Ile Val Glu Thr His Phe Thr Phe Lys 
            100                 105                 110         


Asp Leu His Phe Lys Met Phe Asp Val Gly Gly Gln Arg Ser Glu Arg 
        115                 120                 125             


Lys Lys Trp Ile His Cys Phe Glu Gly Val Thr Ala Ile Ile Phe Cys 
    130                 135                 140                 


Val Ala Leu Ser Ala Tyr Asp Leu Val Leu Ala Glu Asp Glu Glu Met 
145                 150                 155                 160 


Asn Arg Met His Glu Ser Met Lys Leu Phe Asp Ser Ile Cys Asn Asn 
                165                 170                 175     


Lys Trp Phe Thr Asp Thr Ser Ile Ile Leu Phe Leu Asn Lys Lys Asp 
            180                 185                 190         


Leu Phe Glu Glu Lys Ile Thr His Ser Pro Leu Thr Ile Cys Phe Pro 
        195                 200                 205             


Glu Tyr Thr Gly Ala Asn Lys Tyr Asp Glu Ala Ala Ser Tyr Ile Gln 
    210                 215                 220                 


Ser Lys Phe Glu Asp Leu Asn Lys Arg Lys Asp Thr Lys Glu Ile Tyr 
225                 230                 235                 240 


Thr His Phe Thr Cys Ala Thr Asp Thr Lys Asn Val Gln Phe Val Phe 
                245                 250                 255     


Asp Ala Val Thr Asp Val Ile Ile Lys Asn Asn Leu Lys Asp Cys Gly 
            260                 265                 270         


Leu Phe 
        


<210>  89
<211>  1020
<212>  DNA
<213>  Homo sapiens

<400>  89
atggagtatg cagggcatct tcctgccagc tctgcccagg gcaccatatt ggcatgcacc       60

agctgcacag gtgctgggga gtcagggaag agcaccatcg tcaagcagat gaagatcatc      120

cacgaggatg gctactccga ggaggaatgc cggcagtacc gggcggttgt ctacagcaac      180

accatccagt ccatcatggc cattgtcaaa gccatgggca acctgcagat cgactttgcc      240

gacccctcca gagcggacga cgccaggcag ctatttgcac tgtcctgcac cgccgaggag      300

caaggcgtgc tccctgatga cctgtccggc gtcatccgga ggctctgggc tgaccatggt      360

gtgcaggcct gctttggccg ctcaagggaa taccagctca acgactcagc tgcctactac      420

ctgaacgacc tggagcgtat tgcacagagt gactacatcc ccacacagca agatgtgcta      480

cggacccgcg taaagaccac ggggatcgtg gagacacact tcaccttcaa ggacctacac      540

ttcaagatgt ttgatgtggg tggtcagcgg tctgagcgga agaagtggat ccactgcttt      600

gagggcgtca cagccatcat cttctgcgta gccttgagcg cctatgactt ggtgctagct      660

gaggacgagg agatgaaccg catgcatgag agcatgaagc tattcgatag catctgcaac      720

aacaagtggt tcacagacac gtccatcatc ctcttcctca acaagaagga cctgtttgag      780

gagaagatca cacacagtcc cctgaccatc tgcttccctg agtacacagg ggccaacaaa      840

tatgatgagg cagccagcta catccagagt aagtttgagg acctgaataa gcgcaaagac      900

accaaggaga tctacacgca cttcacgtgc gccaccgaca ccaagaacgt gcagttcgtg      960

tttgacgccg tcaccgatgt catcatcaag aacaacctga aggactgcgg cctcttctga     1020


<210>  90
<211>  339
<212>  PRT
<213>  Homo sapiens

<400>  90

Met Glu Tyr Ala Gly His Leu Pro Ala Ser Ser Ala Gln Gly Thr Ile 
1               5                   10                  15      


Leu Ala Cys Thr Ser Cys Thr Gly Ala Gly Glu Ser Gly Lys Ser Thr 
            20                  25                  30          


Ile Val Lys Gln Met Lys Ile Ile His Glu Asp Gly Tyr Ser Glu Glu 
        35                  40                  45              


Glu Cys Arg Gln Tyr Arg Ala Val Val Tyr Ser Asn Thr Ile Gln Ser 
    50                  55                  60                  


Ile Met Ala Ile Val Lys Ala Met Gly Asn Leu Gln Ile Asp Phe Ala 
65                  70                  75                  80  


Asp Pro Ser Arg Ala Asp Asp Ala Arg Gln Leu Phe Ala Leu Ser Cys 
                85                  90                  95      


Thr Ala Glu Glu Gln Gly Val Leu Pro Asp Asp Leu Ser Gly Val Ile 
            100                 105                 110         


Arg Arg Leu Trp Ala Asp His Gly Val Gln Ala Cys Phe Gly Arg Ser 
        115                 120                 125             


Arg Glu Tyr Gln Leu Asn Asp Ser Ala Ala Tyr Tyr Leu Asn Asp Leu 
    130                 135                 140                 


Glu Arg Ile Ala Gln Ser Asp Tyr Ile Pro Thr Gln Gln Asp Val Leu 
145                 150                 155                 160 


Arg Thr Arg Val Lys Thr Thr Gly Ile Val Glu Thr His Phe Thr Phe 
                165                 170                 175     


Lys Asp Leu His Phe Lys Met Phe Asp Val Gly Gly Gln Arg Ser Glu 
            180                 185                 190         


Arg Lys Lys Trp Ile His Cys Phe Glu Gly Val Thr Ala Ile Ile Phe 
        195                 200                 205             


Cys Val Ala Leu Ser Ala Tyr Asp Leu Val Leu Ala Glu Asp Glu Glu 
    210                 215                 220                 


Met Asn Arg Met His Glu Ser Met Lys Leu Phe Asp Ser Ile Cys Asn 
225                 230                 235                 240 


Asn Lys Trp Phe Thr Asp Thr Ser Ile Ile Leu Phe Leu Asn Lys Lys 
                245                 250                 255     


Asp Leu Phe Glu Glu Lys Ile Thr His Ser Pro Leu Thr Ile Cys Phe 
            260                 265                 270         


Pro Glu Tyr Thr Gly Ala Asn Lys Tyr Asp Glu Ala Ala Ser Tyr Ile 
        275                 280                 285             


Gln Ser Lys Phe Glu Asp Leu Asn Lys Arg Lys Asp Thr Lys Glu Ile 
    290                 295                 300                 


Tyr Thr His Phe Thr Cys Ala Thr Asp Thr Lys Asn Val Gln Phe Val 
305                 310                 315                 320 


Phe Asp Ala Val Thr Asp Val Ile Ile Lys Asn Asn Leu Lys Asp Cys 
                325                 330                 335     


Gly Leu Phe 
            


<210>  91
<211>  1020
<212>  DNA
<213>  Homo sapiens

<400>  91
atgacggagg gtgtgaagac gctaggctgg acgaagcaga aaggcgggtg tcactgggga       60

cgttctgagg gtgctgggga gtcagggaag agcaccatcg tcaagcagat gaagatcatc      120

cacgaggatg gctactccga ggaggaatgc cggcagtacc gggcggttgt ctacagcaac      180

accatccagt ccatcatggc cattgtcaaa gccatgggca acctgcagat cgactttgcc      240

gacccctcca gagcggacga cgccaggcag ctatttgcac tgtcctgcac cgccgaggag      300

caaggcgtgc tccctgatga cctgtccggc gtcatccgga ggctctgggc tgaccatggt      360

gtgcaggcct gctttggccg ctcaagggaa taccagctca acgactcagc tgcctactac      420

ctgaacgacc tggagcgtat tgcacagagt gactacatcc ccacacagca agatgtgcta      480

cggacccgcg taaagaccac ggggatcgtg gagacacact tcaccttcaa ggacctacac      540

ttcaagatgt ttgatgtggg tggtcagcgg tctgagcgga agaagtggat ccactgcttt      600

gagggcgtca cagccatcat cttctgcgta gccttgagcg cctatgactt ggtgctagct      660

gaggacgagg agatgaaccg catgcatgag agcatgaagc tattcgatag catctgcaac      720

aacaagtggt tcacagacac gtccatcatc ctcttcctca acaagaagga cctgtttgag      780

gagaagatca cacacagtcc cctgaccatc tgcttccctg agtacacagg ggccaacaaa      840

tatgatgagg cagccagcta catccagagt aagtttgagg acctgaataa gcgcaaagac      900

accaaggaga tctacacgca cttcacgtgc gccaccgaca ccaagaacgt gcagttcgtg      960

tttgacgccg tcaccgatgt catcatcaag aacaacctga aggactgcgg cctcttctga     1020


<210>  92
<211>  339
<212>  PRT
<213>  Homo sapiens

<400>  92

Met Thr Glu Gly Val Lys Thr Leu Gly Trp Thr Lys Gln Lys Gly Gly 
1               5                   10                  15      


Cys His Trp Gly Arg Ser Glu Gly Ala Gly Glu Ser Gly Lys Ser Thr 
            20                  25                  30          


Ile Val Lys Gln Met Lys Ile Ile His Glu Asp Gly Tyr Ser Glu Glu 
        35                  40                  45              


Glu Cys Arg Gln Tyr Arg Ala Val Val Tyr Ser Asn Thr Ile Gln Ser 
    50                  55                  60                  


Ile Met Ala Ile Val Lys Ala Met Gly Asn Leu Gln Ile Asp Phe Ala 
65                  70                  75                  80  


Asp Pro Ser Arg Ala Asp Asp Ala Arg Gln Leu Phe Ala Leu Ser Cys 
                85                  90                  95      


Thr Ala Glu Glu Gln Gly Val Leu Pro Asp Asp Leu Ser Gly Val Ile 
            100                 105                 110         


Arg Arg Leu Trp Ala Asp His Gly Val Gln Ala Cys Phe Gly Arg Ser 
        115                 120                 125             


Arg Glu Tyr Gln Leu Asn Asp Ser Ala Ala Tyr Tyr Leu Asn Asp Leu 
    130                 135                 140                 


Glu Arg Ile Ala Gln Ser Asp Tyr Ile Pro Thr Gln Gln Asp Val Leu 
145                 150                 155                 160 


Arg Thr Arg Val Lys Thr Thr Gly Ile Val Glu Thr His Phe Thr Phe 
                165                 170                 175     


Lys Asp Leu His Phe Lys Met Phe Asp Val Gly Gly Gln Arg Ser Glu 
            180                 185                 190         


Arg Lys Lys Trp Ile His Cys Phe Glu Gly Val Thr Ala Ile Ile Phe 
        195                 200                 205             


Cys Val Ala Leu Ser Ala Tyr Asp Leu Val Leu Ala Glu Asp Glu Glu 
    210                 215                 220                 


Met Asn Arg Met His Glu Ser Met Lys Leu Phe Asp Ser Ile Cys Asn 
225                 230                 235                 240 


Asn Lys Trp Phe Thr Asp Thr Ser Ile Ile Leu Phe Leu Asn Lys Lys 
                245                 250                 255     


Asp Leu Phe Glu Glu Lys Ile Thr His Ser Pro Leu Thr Ile Cys Phe 
            260                 265                 270         


Pro Glu Tyr Thr Gly Ala Asn Lys Tyr Asp Glu Ala Ala Ser Tyr Ile 
        275                 280                 285             


Gln Ser Lys Phe Glu Asp Leu Asn Lys Arg Lys Asp Thr Lys Glu Ile 
    290                 295                 300                 


Tyr Thr His Phe Thr Cys Ala Thr Asp Thr Lys Asn Val Gln Phe Val 
305                 310                 315                 320 


Phe Asp Ala Val Thr Asp Val Ile Ile Lys Asn Asn Leu Lys Asp Cys 
                325                 330                 335     


Gly Leu Phe 
            


<210>  93
<211>  1065
<212>  DNA
<213>  Homo sapiens

<400>  93
atgggctgca cgttgagcgc cgaagacaag gcggcagtgg agcgaagcaa gatgatcgac       60

cgcaacttac gggaggacgg ggaaaaagcg gccaaagaag tgaagctgct gctactcggt      120

gctggagaat ctggtaaaag caccattgtg aaacagatga aaatcattca tgaggatggc      180

tattcagagg atgaatgtaa acaatataaa gtagttgtct acagcaatac tatacagtcc      240

atcattgcaa tcataagagc catgggacgg ctaaagattg actttgggga agctgccagg      300

gcagatgatg cccggcaatt atttgtttta gctggcagtg ctgaagaagg agtcatgact      360

ccagaactag caggagtgat taaacggtta tggcgagatg gtggggtaca agcttgcttc      420

agcagatcca gggaatatca gctcaatgat tctgcttcat attatctaaa tgatctggat      480

agaatatccc agtctaacta cattccaact cagcaagatg ttcttcggac gagagtgaag      540

accacaggca ttgtagaaac acatttcacc ttcaaagacc tatacttcaa gatgtttgat      600

gtaggtggcc aaagatcaga acgaaaaaag tggattcact gttttgaggg agtgacagca      660

attatcttct gtgtggccct cagtgattat gaccttgttc tggctgagga cgaggagatg      720

aaccgaatgc atgaaagcat gaaactgttt gacagcattt gtaataacaa atggtttaca      780

gaaacttcaa tcattctctt ccttaacaag aaagaccttt ttgaggaaaa aataaagagg      840

agtccgttaa ctatctgtta tccagaatac acaggttcca atacatatga agaggcagct      900

gcctatattc aatgccagtt tgaagatctg aacagaagaa aagataccaa ggagatctat      960

actcacttca cctgtgccac agacacgaag aatgtgcagt ttgtttttga tgctgttaca     1020

gatgtcatca ttaaaaacaa cttaaaggaa tgtggacttt attga                     1065


<210>  94
<211>  354
<212>  PRT
<213>  Homo sapiens

<400>  94

Met Gly Cys Thr Leu Ser Ala Glu Asp Lys Ala Ala Val Glu Arg Ser 
1               5                   10                  15      


Lys Met Ile Asp Arg Asn Leu Arg Glu Asp Gly Glu Lys Ala Ala Lys 
            20                  25                  30          


Glu Val Lys Leu Leu Leu Leu Gly Ala Gly Glu Ser Gly Lys Ser Thr 
        35                  40                  45              


Ile Val Lys Gln Met Lys Ile Ile His Glu Asp Gly Tyr Ser Glu Asp 
    50                  55                  60                  


Glu Cys Lys Gln Tyr Lys Val Val Val Tyr Ser Asn Thr Ile Gln Ser 
65                  70                  75                  80  


Ile Ile Ala Ile Ile Arg Ala Met Gly Arg Leu Lys Ile Asp Phe Gly 
                85                  90                  95      


Glu Ala Ala Arg Ala Asp Asp Ala Arg Gln Leu Phe Val Leu Ala Gly 
            100                 105                 110         


Ser Ala Glu Glu Gly Val Met Thr Pro Glu Leu Ala Gly Val Ile Lys 
        115                 120                 125             


Arg Leu Trp Arg Asp Gly Gly Val Gln Ala Cys Phe Ser Arg Ser Arg 
    130                 135                 140                 


Glu Tyr Gln Leu Asn Asp Ser Ala Ser Tyr Tyr Leu Asn Asp Leu Asp 
145                 150                 155                 160 


Arg Ile Ser Gln Ser Asn Tyr Ile Pro Thr Gln Gln Asp Val Leu Arg 
                165                 170                 175     


Thr Arg Val Lys Thr Thr Gly Ile Val Glu Thr His Phe Thr Phe Lys 
            180                 185                 190         


Asp Leu Tyr Phe Lys Met Phe Asp Val Gly Gly Gln Arg Ser Glu Arg 
        195                 200                 205             


Lys Lys Trp Ile His Cys Phe Glu Gly Val Thr Ala Ile Ile Phe Cys 
    210                 215                 220                 


Val Ala Leu Ser Asp Tyr Asp Leu Val Leu Ala Glu Asp Glu Glu Met 
225                 230                 235                 240 


Asn Arg Met His Glu Ser Met Lys Leu Phe Asp Ser Ile Cys Asn Asn 
                245                 250                 255     


Lys Trp Phe Thr Glu Thr Ser Ile Ile Leu Phe Leu Asn Lys Lys Asp 
            260                 265                 270         


Leu Phe Glu Glu Lys Ile Lys Arg Ser Pro Leu Thr Ile Cys Tyr Pro 
        275                 280                 285             


Glu Tyr Thr Gly Ser Asn Thr Tyr Glu Glu Ala Ala Ala Tyr Ile Gln 
    290                 295                 300                 


Cys Gln Phe Glu Asp Leu Asn Arg Arg Lys Asp Thr Lys Glu Ile Tyr 
305                 310                 315                 320 


Thr His Phe Thr Cys Ala Thr Asp Thr Lys Asn Val Gln Phe Val Phe 
                325                 330                 335     


Asp Ala Val Thr Asp Val Ile Ile Lys Asn Asn Leu Lys Glu Cys Gly 
            340                 345                 350         


Leu Tyr 
        


<210>  95
<211>  1185
<212>  DNA
<213>  Homo sapiens

<400>  95
atgggctgcc tcgggaacag taagaccgag gaccagcgca acgaggagaa ggcgcagcgt       60

gaggccaaca aaaagatcga gaagcagctg cagaaggaca agcaggtcta ccgggccacg      120

caccgcctgc tgctgctggg tgctggagaa tctggtaaaa gcaccattgt gaagcagatg      180

aggatcctgc atgttaatgg gtttaatgga gagggcggcg aagaggaccc gcaggctgca      240

aggagcaaca gcgatggtga gaaggcaacc aaagtgcagg acatcaaaaa caacctgaaa      300

gaggcgattg aaaccattgt ggccgccatg agcaacctgg tgccccccgt ggagctggcc      360

aaccccgaga accagttcag agtggactac atcctgagtg tgatgaacgt gcctgacttt      420

gacttccctc ccgaattcta tgagcatgcc aaggctctgt gggaggatga aggagtgcgt      480

gcctgctacg aacgctccaa cgagtaccag ctgattgact gtgcccagta cttcctggac      540

aagatcgacg tgatcaagca ggctgactat gtgccgagcg atcaggacct gcttcgctgc      600

cgtgtcctga cttctggaat ctttgagacc aagttccagg tggacaaagt caacttccac      660

atgtttgacg tgggtggcca gcgcgatgaa cgccgcaagt ggatccagtg cttcaacgat      720

gtgactgcca tcatcttcgt ggtggccagc agcagctaca acatggtcat ccgggaggac      780

aaccagacca accgcctgca ggaggctctg aacctcttca agagcatctg gaacaacaga      840

tggctgcgca ccatctctgt gatcctgttc ctcaacaagc aagatctgct cgctgagaaa      900

gtccttgctg ggaaatcgaa gattgaggac tactttccag aatttgctcg ctacactact      960

cctgaggatg ctactcccga gcccggagag gacccacgcg tgacccgggc caagtacttc     1020

attcgagatg agtttctgag gatcagcact gccagtggag atgggcgtca ctactgctac     1080

cctcatttca cctgcgctgt ggacactgag aacatccgcc gtgtgttcaa cgactgccgt     1140

gacatcattc agcgcatgca ccttcgtcag tacgagctgc tctaa                     1185


<210>  96
<211>  394
<212>  PRT
<213>  Homo sapiens

<400>  96

Met Gly Cys Leu Gly Asn Ser Lys Thr Glu Asp Gln Arg Asn Glu Glu 
1               5                   10                  15      


Lys Ala Gln Arg Glu Ala Asn Lys Lys Ile Glu Lys Gln Leu Gln Lys 
            20                  25                  30          


Asp Lys Gln Val Tyr Arg Ala Thr His Arg Leu Leu Leu Leu Gly Ala 
        35                  40                  45              


Gly Glu Ser Gly Lys Ser Thr Ile Val Lys Gln Met Arg Ile Leu His 
    50                  55                  60                  


Val Asn Gly Phe Asn Gly Glu Gly Gly Glu Glu Asp Pro Gln Ala Ala 
65                  70                  75                  80  


Arg Ser Asn Ser Asp Gly Glu Lys Ala Thr Lys Val Gln Asp Ile Lys 
                85                  90                  95      


Asn Asn Leu Lys Glu Ala Ile Glu Thr Ile Val Ala Ala Met Ser Asn 
            100                 105                 110         


Leu Val Pro Pro Val Glu Leu Ala Asn Pro Glu Asn Gln Phe Arg Val 
        115                 120                 125             


Asp Tyr Ile Leu Ser Val Met Asn Val Pro Asp Phe Asp Phe Pro Pro 
    130                 135                 140                 


Glu Phe Tyr Glu His Ala Lys Ala Leu Trp Glu Asp Glu Gly Val Arg 
145                 150                 155                 160 


Ala Cys Tyr Glu Arg Ser Asn Glu Tyr Gln Leu Ile Asp Cys Ala Gln 
                165                 170                 175     


Tyr Phe Leu Asp Lys Ile Asp Val Ile Lys Gln Ala Asp Tyr Val Pro 
            180                 185                 190         


Ser Asp Gln Asp Leu Leu Arg Cys Arg Val Leu Thr Ser Gly Ile Phe 
        195                 200                 205             


Glu Thr Lys Phe Gln Val Asp Lys Val Asn Phe His Met Phe Asp Val 
    210                 215                 220                 


Gly Gly Gln Arg Asp Glu Arg Arg Lys Trp Ile Gln Cys Phe Asn Asp 
225                 230                 235                 240 


Val Thr Ala Ile Ile Phe Val Val Ala Ser Ser Ser Tyr Asn Met Val 
                245                 250                 255     


Ile Arg Glu Asp Asn Gln Thr Asn Arg Leu Gln Glu Ala Leu Asn Leu 
            260                 265                 270         


Phe Lys Ser Ile Trp Asn Asn Arg Trp Leu Arg Thr Ile Ser Val Ile 
        275                 280                 285             


Leu Phe Leu Asn Lys Gln Asp Leu Leu Ala Glu Lys Val Leu Ala Gly 
    290                 295                 300                 


Lys Ser Lys Ile Glu Asp Tyr Phe Pro Glu Phe Ala Arg Tyr Thr Thr 
305                 310                 315                 320 


Pro Glu Asp Ala Thr Pro Glu Pro Gly Glu Asp Pro Arg Val Thr Arg 
                325                 330                 335     


Ala Lys Tyr Phe Ile Arg Asp Glu Phe Leu Arg Ile Ser Thr Ala Ser 
            340                 345                 350         


Gly Asp Gly Arg His Tyr Cys Tyr Pro His Phe Thr Cys Ala Val Asp 
        355                 360                 365             


Thr Glu Asn Ile Arg Arg Val Phe Asn Asp Cys Arg Asp Ile Ile Gln 
    370                 375                 380                 


Arg Met His Leu Arg Gln Tyr Glu Leu Leu 
385                 390                 


<210>  97
<211>  18
<212>  DNA
<213>  ARTIFICIAL

<220>
<223>  Synthetic Construct

<400>  97
gagagggaaa gaagggga                                                     18


<210>  98
<211>  23
<212>  DNA
<213>  ARTIFICIAL

<220>
<223>  Synthetic Construct

<400>  98
gaggaccgaa aagcgcaaag aca                                               23


<210>  99
<211>  15
<212>  DNA
<213>  ARTIFICIAL

<220>
<223>  Synthetic Construct

<400>  99
cagccaagac gccaa                                                        15


<210>  100
<211>  22
<212>  DNA
<213>  ARTIFICIAL

<220>
<223>  Synthetic Construct

<400>  100
acaacaggca ccgggaggac aa                                                22


