                         SEQUENCE LISTING

<110>  Externautics S.p.A.
 
<120>  Tumor marker, monoclonal antibodies and methods of use thereof

<130>  1571PCT

<160>  49    

<170>  PatentIn version 3.5

<210>  1
<211>  4588
<212>  PRT
<213>  Homo sapiens

<400>  1

Met Gly Arg His Leu Ala Leu Leu Leu Leu Leu Leu Leu Leu Phe Gln 
1               5                   10                  15      


His Phe Gly Asp Ser Asp Gly Ser Gln Arg Leu Glu Gln Thr Pro Leu 
            20                  25                  30          


Gln Phe Thr His Leu Glu Tyr Asn Val Thr Val Gln Glu Asn Ser Ala 
        35                  40                  45              


Ala Lys Thr Tyr Val Gly His Pro Val Lys Met Gly Val Tyr Ile Thr 
    50                  55                  60                  


His Pro Ala Trp Glu Val Arg Tyr Lys Ile Val Ser Gly Asp Ser Glu 
65                  70                  75                  80  


Asn Leu Phe Lys Ala Glu Glu Tyr Ile Leu Gly Asp Phe Cys Phe Leu 
                85                  90                  95      


Arg Ile Arg Thr Lys Gly Gly Asn Thr Ala Ile Leu Asn Arg Glu Val 
            100                 105                 110         


Lys Asp His Tyr Thr Leu Ile Val Lys Ala Leu Glu Lys Asn Thr Asn 
        115                 120                 125             


Val Glu Ala Arg Thr Lys Val Arg Val Gln Val Leu Asp Thr Asn Asp 
    130                 135                 140                 


Leu Arg Pro Leu Phe Ser Pro Thr Ser Tyr Ser Val Ser Leu Pro Glu 
145                 150                 155                 160 


Asn Thr Ala Ile Arg Thr Ser Ile Ala Arg Val Ser Ala Thr Asp Ala 
                165                 170                 175     


Asp Ile Gly Thr Asn Gly Glu Phe Tyr Tyr Ser Phe Lys Asp Arg Thr 
            180                 185                 190         


Asp Met Phe Ala Ile His Pro Thr Ser Gly Val Ile Val Leu Thr Gly 
        195                 200                 205             


Arg Leu Asp Tyr Leu Glu Thr Lys Leu Tyr Glu Met Glu Ile Leu Ala 
    210                 215                 220                 


Ala Asp Arg Gly Met Lys Leu Tyr Gly Ser Ser Gly Ile Ser Ser Met 
225                 230                 235                 240 


Ala Lys Leu Thr Val His Ile Glu Gln Ala Asn Glu Cys Ala Pro Val 
                245                 250                 255     


Ile Thr Ala Val Thr Leu Ser Pro Ser Glu Leu Asp Arg Asp Pro Ala 
            260                 265                 270         


Tyr Ala Ile Val Thr Val Asp Asp Cys Asp Gln Gly Ala Asn Gly Asp 
        275                 280                 285             


Ile Ala Ser Leu Ser Ile Val Ala Gly Asp Leu Leu Gln Gln Phe Arg 
    290                 295                 300                 


Thr Val Arg Ser Phe Pro Gly Ser Lys Glu Tyr Lys Val Lys Ala Ile 
305                 310                 315                 320 


Gly Gly Ile Asp Trp Asp Ser His Pro Phe Gly Tyr Asn Leu Thr Leu 
                325                 330                 335     


Gln Ala Lys Asp Lys Gly Thr Pro Pro Gln Phe Ser Ser Val Lys Val 
            340                 345                 350         


Ile His Val Thr Ser Pro Gln Phe Lys Ala Gly Pro Val Lys Phe Glu 
        355                 360                 365             


Lys Asp Val Tyr Arg Ala Glu Ile Ser Glu Phe Ala Pro Pro Asn Thr 
    370                 375                 380                 


Pro Val Val Met Val Lys Ala Ile Pro Ala Tyr Ser His Leu Arg Tyr 
385                 390                 395                 400 


Val Phe Lys Ser Thr Pro Gly Lys Ala Lys Phe Ser Leu Asn Tyr Asn 
                405                 410                 415     


Thr Gly Leu Ile Ser Ile Leu Glu Pro Val Lys Arg Gln Gln Ala Ala 
            420                 425                 430         


His Phe Glu Leu Glu Val Thr Thr Ser Asp Arg Lys Ala Ser Thr Lys 
        435                 440                 445             


Val Leu Val Lys Val Leu Gly Ala Asn Ser Asn Pro Pro Glu Phe Thr 
    450                 455                 460                 


Gln Thr Ala Tyr Lys Ala Ala Phe Asp Glu Asn Val Pro Ile Gly Thr 
465                 470                 475                 480 


Thr Val Met Ser Leu Ser Ala Val Asp Pro Asp Glu Gly Glu Asn Gly 
                485                 490                 495     


Tyr Val Thr Tyr Ser Ile Ala Asn Leu Asn His Val Pro Phe Ala Ile 
            500                 505                 510         


Asp His Phe Thr Gly Ala Val Ser Thr Ser Glu Asn Leu Asp Tyr Glu 
        515                 520                 525             


Leu Met Pro Arg Val Tyr Thr Leu Arg Ile Arg Ala Ser Asp Trp Gly 
    530                 535                 540                 


Leu Pro Tyr Arg Arg Glu Val Glu Val Leu Ala Thr Ile Thr Leu Asn 
545                 550                 555                 560 


Asn Leu Asn Asp Asn Thr Pro Leu Phe Glu Lys Ile Asn Cys Glu Gly 
                565                 570                 575     


Thr Ile Pro Arg Asp Leu Gly Val Gly Glu Gln Ile Thr Thr Val Ser 
            580                 585                 590         


Ala Ile Asp Ala Asp Glu Leu Gln Leu Val Gln Tyr Gln Ile Glu Ala 
        595                 600                 605             


Gly Asn Glu Leu Asp Phe Phe Ser Leu Asn Pro Asn Ser Gly Val Leu 
    610                 615                 620                 


Ser Leu Lys Arg Ser Leu Met Asp Gly Leu Gly Ala Lys Val Ser Phe 
625                 630                 635                 640 


His Ser Leu Arg Ile Thr Ala Thr Asp Gly Glu Asn Phe Ala Thr Pro 
                645                 650                 655     


Leu Tyr Ile Asn Ile Thr Val Ala Ala Ser His Lys Leu Val Asn Leu 
            660                 665                 670         


Gln Cys Glu Glu Thr Gly Val Ala Lys Met Leu Ala Glu Lys Leu Leu 
        675                 680                 685             


Gln Ala Asn Lys Leu His Asn Gln Gly Glu Val Glu Asp Ile Phe Phe 
    690                 695                 700                 


Asp Ser His Ser Val Asn Ala His Ile Pro Gln Phe Arg Ser Thr Leu 
705                 710                 715                 720 


Pro Thr Gly Ile Gln Val Lys Glu Asn Gln Pro Val Gly Ser Ser Val 
                725                 730                 735     


Ile Phe Met Asn Ser Thr Asp Leu Asp Thr Gly Phe Asn Gly Lys Leu 
            740                 745                 750         


Val Tyr Ala Val Ser Gly Gly Asn Glu Asp Ser Cys Phe Met Ile Asp 
        755                 760                 765             


Met Glu Thr Gly Met Leu Lys Ile Leu Ser Pro Leu Asp Arg Glu Thr 
    770                 775                 780                 


Thr Asp Lys Tyr Thr Leu Asn Ile Thr Val Tyr Asp Leu Gly Ile Pro 
785                 790                 795                 800 


Gln Lys Ala Ala Trp Arg Leu Leu His Val Val Val Val Asp Ala Asn 
                805                 810                 815     


Asp Asn Pro Pro Glu Phe Leu Gln Glu Ser Tyr Phe Val Glu Val Ser 
            820                 825                 830         


Glu Asp Lys Glu Val His Ser Glu Ile Ile Gln Val Glu Ala Thr Asp 
        835                 840                 845             


Lys Asp Leu Gly Pro Asn Gly His Val Thr Tyr Ser Ile Val Thr Asp 
    850                 855                 860                 


Thr Asp Thr Phe Ser Ile Asp Ser Val Thr Gly Val Val Asn Ile Ala 
865                 870                 875                 880 


Arg Pro Leu Asp Arg Glu Leu Gln His Glu His Ser Leu Lys Ile Glu 
                885                 890                 895     


Ala Arg Asp Gln Ala Arg Glu Glu Pro Gln Leu Phe Ser Thr Val Val 
            900                 905                 910         


Val Lys Val Ser Leu Glu Asp Val Asn Asp Asn Pro Pro Thr Phe Ile 
        915                 920                 925             


Pro Pro Asn Tyr Arg Val Lys Val Arg Glu Asp Leu Pro Glu Gly Thr 
    930                 935                 940                 


Val Ile Met Trp Leu Glu Ala His Asp Pro Asp Leu Gly Gln Ser Gly 
945                 950                 955                 960 


Gln Val Arg Tyr Ser Leu Leu Asp His Gly Glu Gly Asn Phe Asp Val 
                965                 970                 975     


Asp Lys Leu Ser Gly Ala Val Arg Ile Val Gln Gln Leu Asp Phe Glu 
            980                 985                 990         


Lys Lys Gln Val Tyr Asn Leu Thr  Val Arg Ala Lys Asp  Lys Gly Lys 
        995                 1000                 1005             


Pro Val  Ser Leu Ser Ser Thr  Cys Tyr Val Glu Val  Glu Val Val 
    1010                 1015                 1020             


Asp Val  Asn Glu Asn Leu His  Pro Pro Val Phe Ser  Ser Phe Val 
    1025                 1030                 1035             


Glu Lys  Gly Thr Val Lys Glu  Asp Ala Pro Val Gly  Ser Leu Val 
    1040                 1045                 1050             


Met Thr  Val Ser Ala His Asp  Glu Asp Ala Arg Arg  Asp Gly Glu 
    1055                 1060                 1065             


Ile Arg  Tyr Ser Ile Arg Asp  Gly Ser Gly Val Gly  Val Phe Lys 
    1070                 1075                 1080             


Ile Gly  Glu Glu Thr Gly Val  Ile Glu Thr Ser Asp  Arg Leu Asp 
    1085                 1090                 1095             


Arg Glu  Ser Thr Ser His Tyr  Trp Leu Thr Val Phe  Ala Thr Asp 
    1100                 1105                 1110             


Gln Gly  Val Val Pro Leu Ser  Ser Phe Ile Glu Ile  Tyr Ile Glu 
    1115                 1120                 1125             


Val Glu  Asp Val Asn Asp Asn  Ala Pro Gln Thr Ser  Glu Pro Val 
    1130                 1135                 1140             


Tyr Tyr  Pro Glu Ile Met Glu  Asn Ser Pro Lys Asp  Val Ser Val 
    1145                 1150                 1155             


Val Gln  Ile Glu Ala Phe Asp  Pro Asp Ser Ser Ser  Asn Asp Lys 
    1160                 1165                 1170             


Leu Met  Tyr Lys Ile Thr Ser  Gly Asn Pro Gln Gly  Phe Phe Ser 
    1175                 1180                 1185             


Ile His  Pro Lys Thr Gly Leu  Ile Thr Thr Thr Ser  Arg Lys Leu 
    1190                 1195                 1200             


Asp Arg  Glu Gln Gln Asp Glu  His Ile Leu Glu Val  Thr Val Thr 
    1205                 1210                 1215             


Asp Asn  Gly Ser Pro Pro Lys  Ser Thr Ile Ala Arg  Val Ile Val 
    1220                 1225                 1230             


Lys Ile  Leu Asp Glu Asn Asp  Asn Lys Pro Gln Phe  Leu Gln Lys 
    1235                 1240                 1245             


Phe Tyr  Lys Ile Arg Leu Pro  Glu Arg Glu Lys Pro  Asp Arg Glu 
    1250                 1255                 1260             


Arg Asn  Ala Arg Arg Glu Pro  Leu Tyr His Val Ile  Ala Thr Asp 
    1265                 1270                 1275             


Lys Asp  Glu Gly Pro Asn Ala  Glu Ile Ser Tyr Ser  Ile Glu Asp 
    1280                 1285                 1290             


Gly Asn  Glu His Gly Lys Phe  Phe Ile Glu Pro Lys  Thr Gly Val 
    1295                 1300                 1305             


Val Ser  Ser Lys Arg Phe Ser  Ala Ala Gly Glu Tyr  Asp Ile Leu 
    1310                 1315                 1320             


Ser Ile  Lys Ala Val Asp Asn  Gly Arg Pro Gln Lys  Ser Ser Thr 
    1325                 1330                 1335             


Thr Arg  Leu His Ile Glu Trp  Ile Ser Lys Pro Lys  Pro Ser Leu 
    1340                 1345                 1350             


Glu Pro  Ile Ser Phe Glu Glu  Ser Phe Phe Thr Phe  Thr Val Met 
    1355                 1360                 1365             


Glu Ser  Asp Pro Val Ala His  Met Ile Gly Val Ile  Ser Val Glu 
    1370                 1375                 1380             


Pro Pro  Gly Ile Pro Leu Trp  Phe Asp Ile Thr Gly  Gly Asn Tyr 
    1385                 1390                 1395             


Asp Ser  His Phe Asp Val Asp  Lys Gly Thr Gly Thr  Ile Ile Val 
    1400                 1405                 1410             


Ala Lys  Pro Leu Asp Ala Glu  Gln Lys Ser Asn Tyr  Asn Leu Thr 
    1415                 1420                 1425             


Val Glu  Ala Thr Asp Gly Thr  Thr Thr Ile Leu Thr  Gln Val Phe 
    1430                 1435                 1440             


Ile Lys  Val Ile Asp Thr Asn  Asp His Arg Pro Gln  Phe Ser Thr 
    1445                 1450                 1455             


Ser Lys  Tyr Glu Val Val Ile  Pro Glu Asp Thr Ala  Pro Glu Thr 
    1460                 1465                 1470             


Glu Ile  Leu Gln Ile Ser Ala  Val Asp Gln Asp Glu  Lys Asn Lys 
    1475                 1480                 1485             


Leu Ile  Tyr Thr Leu Gln Ser  Ser Arg Asp Pro Leu  Ser Leu Lys 
    1490                 1495                 1500             


Lys Phe  Arg Leu Asp Pro Ala  Thr Gly Ser Leu Tyr  Thr Ser Glu 
    1505                 1510                 1515             


Lys Leu  Asp His Glu Ala Val  His Gln His Thr Leu  Thr Val Met 
    1520                 1525                 1530             


Val Arg  Asp Gln Asp Val Pro  Val Lys Arg Asn Phe  Ala Arg Ile 
    1535                 1540                 1545             


Val Val  Asn Val Ser Asp Thr  Asn Asp His Ala Pro  Trp Phe Thr 
    1550                 1555                 1560             


Ala Ser  Ser Tyr Lys Gly Arg  Val Tyr Glu Ser Ala  Ala Val Gly 
    1565                 1570                 1575             


Ser Val  Val Leu Gln Val Thr  Ala Leu Asp Lys Asp  Lys Gly Lys 
    1580                 1585                 1590             


Asn Ala  Glu Val Leu Tyr Ser  Ile Glu Ser Gly Asn  Ile Gly Asn 
    1595                 1600                 1605             


Ser Phe  Met Ile Asp Pro Val  Leu Gly Ser Ile Lys  Thr Ala Lys 
    1610                 1615                 1620             


Glu Leu  Asp Arg Ser Asn Gln  Ala Glu Tyr Asp Leu  Met Val Lys 
    1625                 1630                 1635             


Ala Thr  Asp Lys Gly Ser Pro  Pro Met Ser Glu Ile  Thr Ser Val 
    1640                 1645                 1650             


Arg Ile  Phe Val Thr Ile Ala  Asp Asn Ala Ser Pro  Lys Phe Thr 
    1655                 1660                 1665             


Ser Lys  Glu Tyr Ser Val Glu  Leu Ser Glu Thr Val  Ser Ile Gly 
    1670                 1675                 1680             


Ser Phe  Val Gly Met Val Thr  Ala His Ser Gln Ser  Ser Val Val 
    1685                 1690                 1695             


Tyr Glu  Ile Lys Asp Gly Asn  Thr Gly Asp Ala Phe  Asp Ile Asn 
    1700                 1705                 1710             


Pro His  Ser Gly Thr Ile Ile  Thr Gln Lys Ala Leu  Asp Phe Glu 
    1715                 1720                 1725             


Thr Leu  Pro Ile Tyr Thr Leu  Ile Ile Gln Gly Thr  Asn Met Ala 
    1730                 1735                 1740             


Gly Leu  Ser Thr Asn Thr Thr  Val Leu Val His Leu  Gln Asp Glu 
    1745                 1750                 1755             


Asn Asp  Asn Ala Pro Val Phe  Met Gln Ala Glu Tyr  Thr Gly Leu 
    1760                 1765                 1770             


Ile Ser  Glu Ser Ala Ser Ile  Asn Ser Val Val Leu  Thr Asp Arg 
    1775                 1780                 1785             


Asn Val  Pro Leu Val Ile Arg  Ala Ala Asp Ala Asp  Lys Asp Ser 
    1790                 1795                 1800             


Asn Ala  Leu Leu Val Tyr His  Ile Val Glu Pro Ser  Val His Thr 
    1805                 1810                 1815             


Tyr Phe  Ala Ile Asp Ser Ser  Thr Gly Ala Ile His  Thr Val Leu 
    1820                 1825                 1830             


Ser Leu  Asp Tyr Glu Glu Thr  Ser Ile Phe His Phe  Thr Val Gln 
    1835                 1840                 1845             


Val His  Asp Met Gly Thr Pro  Arg Leu Phe Ala Glu  Tyr Ala Ala 
    1850                 1855                 1860             


Asn Val  Thr Val His Val Ile  Asp Ile Asn Asp Cys  Pro Pro Val 
    1865                 1870                 1875             


Phe Ala  Lys Pro Leu Tyr Glu  Ala Ser Leu Leu Leu  Pro Thr Tyr 
    1880                 1885                 1890             


Lys Gly  Val Lys Val Ile Thr  Val Asn Ala Thr Asp  Ala Asp Ser 
    1895                 1900                 1905             


Ser Ala  Phe Ser Gln Leu Ile  Tyr Ser Ile Thr Glu  Gly Asn Ile 
    1910                 1915                 1920             


Gly Glu  Lys Phe Ser Met Asp  Tyr Lys Thr Gly Ala  Leu Thr Val 
    1925                 1930                 1935             


Gln Asn  Thr Thr Gln Leu Arg  Ser Arg Tyr Glu Leu  Thr Val Arg 
    1940                 1945                 1950             


Ala Ser  Asp Gly Arg Phe Ala  Gly Leu Thr Ser Val  Lys Ile Asn 
    1955                 1960                 1965             


Val Lys  Glu Ser Lys Glu Ser  His Leu Lys Phe Thr  Gln Asp Val 
    1970                 1975                 1980             


Tyr Ser  Ala Val Val Lys Glu  Asn Ser Thr Glu Ala  Glu Thr Leu 
    1985                 1990                 1995             


Ala Val  Ile Thr Ala Ile Gly  Asn Pro Ile Asn Glu  Pro Leu Phe 
    2000                 2005                 2010             


Tyr His  Ile Leu Asn Pro Asp  Arg Arg Phe Lys Ile  Ser Arg Thr 
    2015                 2020                 2025             


Ser Gly  Val Leu Ser Thr Thr  Gly Thr Pro Phe Asp  Arg Glu Gln 
    2030                 2035                 2040             


Gln Glu  Ala Phe Asp Val Val  Val Glu Val Thr Glu  Glu His Lys 
    2045                 2050                 2055             


Pro Ser  Ala Val Ala His Val  Val Val Lys Val Ile  Val Glu Asp 
    2060                 2065                 2070             


Gln Asn  Asp Asn Ala Pro Val  Phe Val Asn Leu Pro  Tyr Tyr Ala 
    2075                 2080                 2085             


Val Val  Lys Val Asp Thr Glu  Val Gly His Val Ile  Arg Tyr Val 
    2090                 2095                 2100             


Thr Ala  Val Asp Arg Asp Ser  Gly Arg Asn Gly Glu  Val His Tyr 
    2105                 2110                 2115             


Tyr Leu  Lys Glu His His Glu  His Phe Gln Ile Gly  Pro Leu Gly 
    2120                 2125                 2130             


Glu Ile  Ser Leu Lys Lys Gln  Phe Glu Leu Asp Thr  Leu Asn Lys 
    2135                 2140                 2145             


Glu Tyr  Leu Val Thr Val Val  Ala Lys Asp Gly Gly  Asn Pro Ala 
    2150                 2155                 2160             


Phe Ser  Ala Glu Val Ile Val  Pro Ile Thr Val Met  Asn Lys Ala 
    2165                 2170                 2175             


Met Pro  Val Phe Glu Lys Pro  Phe Tyr Ser Ala Glu  Ile Ala Glu 
    2180                 2185                 2190             


Ser Ile  Gln Val His Ser Pro  Val Val His Val Gln  Ala Asn Ser 
    2195                 2200                 2205             


Pro Glu  Gly Leu Lys Val Phe  Tyr Ser Ile Thr Asp  Gly Asp Pro 
    2210                 2215                 2220             


Phe Ser  Gln Phe Thr Ile Asn  Phe Asn Thr Gly Val  Ile Asn Val 
    2225                 2230                 2235             


Ile Ala  Pro Leu Asp Phe Glu  Ala His Pro Ala Tyr  Lys Leu Ser 
    2240                 2245                 2250             


Ile Arg  Ala Thr Asp Ser Leu  Thr Gly Ala His Ala  Glu Val Phe 
    2255                 2260                 2265             


Val Asp  Ile Ile Val Asp Asp  Ile Asn Asp Asn Pro  Pro Val Phe 
    2270                 2275                 2280             


Ala Gln  Gln Ser Tyr Ala Val  Thr Leu Ser Glu Ala  Ser Val Ile 
    2285                 2290                 2295             


Gly Thr  Ser Val Val Gln Val  Arg Ala Thr Asp Ser  Asp Ser Glu 
    2300                 2305                 2310             


Pro Asn  Arg Gly Ile Ser Tyr  Gln Met Phe Gly Asn  His Ser Lys 
    2315                 2320                 2325             


Ser His  Asp His Phe His Val  Asp Ser Ser Thr Gly  Leu Ile Ser 
    2330                 2335                 2340             


Leu Leu  Arg Thr Leu Asp Tyr  Glu Gln Ser Arg Gln  His Thr Ile 
    2345                 2350                 2355             


Phe Val  Arg Ala Val Asp Gly  Gly Met Pro Thr Leu  Ser Ser Asp 
    2360                 2365                 2370             


Val Ile  Val Thr Val Asp Val  Thr Asp Leu Asn Asp  Asn Pro Pro 
    2375                 2380                 2385             


Leu Phe  Glu Gln Gln Ile Tyr  Glu Ala Arg Ile Ser  Glu His Ala 
    2390                 2395                 2400             


Pro His  Gly His Phe Val Thr  Cys Val Lys Ala Tyr  Asp Ala Asp 
    2405                 2410                 2415             


Ser Ser  Asp Ile Asp Lys Leu  Gln Tyr Ser Ile Leu  Ser Gly Asn 
    2420                 2425                 2430             


Asp His  Lys His Phe Val Ile  Asp Ser Ala Thr Gly  Ile Ile Thr 
    2435                 2440                 2445             


Leu Ser  Asn Leu His Arg His  Ala Leu Lys Pro Phe  Tyr Ser Leu 
    2450                 2455                 2460             


Asn Leu  Ser Val Ser Asp Gly  Val Phe Arg Ser Ser  Thr Gln Val 
    2465                 2470                 2475             


His Val  Thr Val Ile Gly Gly  Asn Leu His Ser Pro  Ala Phe Leu 
    2480                 2485                 2490             


Gln Asn  Glu Tyr Glu Val Glu  Leu Ala Glu Asn Ala  Pro Leu His 
    2495                 2500                 2505             


Thr Leu  Val Met Glu Val Lys  Thr Thr Asp Gly Asp  Ser Gly Ile 
    2510                 2515                 2520             


Tyr Gly  His Val Thr Tyr His  Ile Val Asn Asp Phe  Ala Lys Asp 
    2525                 2530                 2535             


Arg Phe  Tyr Ile Asn Glu Arg  Gly Gln Ile Phe Thr  Leu Glu Lys 
    2540                 2545                 2550             


Leu Asp  Arg Glu Thr Pro Ala  Glu Lys Val Ile Ser  Val Arg Leu 
    2555                 2560                 2565             


Met Ala  Lys Asp Ala Gly Gly  Lys Val Ala Phe Cys  Thr Val Asn 
    2570                 2575                 2580             


Val Ile  Leu Thr Asp Asp Asn  Asp Asn Ala Pro Gln  Phe Arg Ala 
    2585                 2590                 2595             


Thr Lys  Tyr Glu Val Asn Ile  Gly Ser Ser Ala Ala  Lys Gly Thr 
    2600                 2605                 2610             


Ser Val  Val Lys Val Leu Ala  Ser Asp Ala Asp Glu  Gly Ser Asn 
    2615                 2620                 2625             


Ala Asp  Ile Thr Tyr Ala Ile  Glu Ala Asp Ser Glu  Ser Val Lys 
    2630                 2635                 2640             


Glu Asn  Leu Glu Ile Asn Lys  Leu Ser Gly Val Ile  Thr Thr Lys 
    2645                 2650                 2655             


Glu Ser  Leu Ile Gly Leu Glu  Asn Glu Phe Phe Thr  Phe Phe Val 
    2660                 2665                 2670             


Arg Ala  Val Asp Asn Gly Ser  Pro Ser Lys Glu Ser  Val Val Leu 
    2675                 2680                 2685             


Val Tyr  Val Lys Ile Leu Pro  Pro Glu Met Gln Leu  Pro Lys Phe 
    2690                 2695                 2700             


Ser Glu  Pro Phe Tyr Thr Phe  Thr Val Ser Glu Asp  Val Pro Ile 
    2705                 2710                 2715             


Gly Thr  Glu Ile Asp Leu Ile  Arg Ala Glu His Ser  Gly Thr Val 
    2720                 2725                 2730             


Leu Tyr  Ser Leu Val Lys Gly  Asn Thr Pro Glu Ser  Asn Arg Asp 
    2735                 2740                 2745             


Glu Ser  Phe Val Ile Asp Arg  Gln Ser Gly Arg Leu  Lys Leu Glu 
    2750                 2755                 2760             


Lys Ser  Leu Asp His Glu Thr  Thr Lys Trp Tyr Gln  Phe Ser Ile 
    2765                 2770                 2775             


Leu Ala  Arg Cys Thr Gln Asp  Asp His Glu Met Val  Ala Ser Val 
    2780                 2785                 2790             


Asp Val  Ser Ile Gln Val Lys  Asp Ala Asn Asp Asn  Ser Pro Val 
    2795                 2800                 2805             


Phe Glu  Ser Ser Pro Tyr Glu  Ala Phe Ile Val Glu  Asn Leu Pro 
    2810                 2815                 2820             


Gly Gly  Ser Arg Val Ile Gln  Ile Arg Ala Ser Asp  Ala Asp Ser 
    2825                 2830                 2835             


Gly Thr  Asn Gly Gln Val Met  Tyr Ser Leu Asp Gln  Ser Gln Ser 
    2840                 2845                 2850             


Val Glu  Val Ile Glu Ser Phe  Ala Ile Asn Met Glu  Thr Gly Trp 
    2855                 2860                 2865             


Ile Thr  Thr Leu Lys Glu Leu  Asp His Glu Lys Arg  Asp Asn Tyr 
    2870                 2875                 2880             


Gln Ile  Lys Val Val Ala Ser  Asp His Gly Glu Lys  Ile Gln Leu 
    2885                 2890                 2895             


Ser Ser  Thr Ala Ile Val Asp  Val Thr Val Thr Asp  Val Asn Asp 
    2900                 2905                 2910             


Ser Pro  Pro Arg Phe Thr Ala  Glu Ile Tyr Lys Gly  Thr Val Ser 
    2915                 2920                 2925             


Glu Asp  Asp Pro Gln Gly Gly  Val Ile Ala Ile Leu  Ser Thr Thr 
    2930                 2935                 2940             


Asp Ala  Asp Ser Glu Glu Ile  Asn Arg Gln Val Thr  Tyr Phe Ile 
    2945                 2950                 2955             


Thr Gly  Gly Asp Pro Leu Gly  Gln Phe Ala Val Glu  Thr Ile Gln 
    2960                 2965                 2970             


Asn Glu  Trp Lys Val Tyr Val  Lys Lys Pro Leu Asp  Arg Glu Lys 
    2975                 2980                 2985             


Arg Asp  Asn Tyr Leu Leu Thr  Ile Thr Ala Thr Asp  Gly Thr Phe 
    2990                 2995                 3000             


Ser Ser  Lys Ala Ile Val Glu  Val Lys Val Leu Asp  Ala Asn Asp 
    3005                 3010                 3015             


Asn Ser  Pro Val Cys Glu Lys  Thr Leu Tyr Ser Asp  Thr Ile Pro 
    3020                 3025                 3030             


Glu Asp  Val Leu Pro Gly Lys  Leu Ile Met Gln Ile  Ser Ala Thr 
    3035                 3040                 3045             


Asp Ala  Asp Ile Arg Ser Asn  Ala Glu Ile Thr Tyr  Thr Leu Leu 
    3050                 3055                 3060             


Gly Ser  Gly Ala Glu Lys Phe  Lys Leu Asn Pro Asp  Thr Gly Glu 
    3065                 3070                 3075             


Leu Lys  Thr Ser Thr Pro Leu  Asp Arg Glu Glu Gln  Ala Val Tyr 
    3080                 3085                 3090             


His Leu  Leu Val Arg Ala Thr  Asp Gly Gly Gly Arg  Phe Cys Gln 
    3095                 3100                 3105             


Ala Ser  Ile Val Leu Thr Leu  Glu Asp Val Asn Asp  Asn Ala Pro 
    3110                 3115                 3120             


Glu Phe  Ser Ala Asp Pro Tyr  Ala Ile Thr Val Phe  Glu Asn Thr 
    3125                 3130                 3135             


Glu Pro  Gly Thr Leu Leu Thr  Arg Val Gln Ala Thr  Asp Ala Asp 
    3140                 3145                 3150             


Ala Gly  Leu Asn Arg Lys Ile  Leu Tyr Ser Leu Ile  Asp Ser Ala 
    3155                 3160                 3165             


Asp Gly  Gln Phe Ser Ile Asn  Glu Leu Ser Gly Ile  Ile Gln Leu 
    3170                 3175                 3180             


Glu Lys  Pro Leu Asp Arg Glu  Leu Gln Ala Val Tyr  Thr Leu Ser 
    3185                 3190                 3195             


Leu Lys  Ala Val Asp Gln Gly  Leu Pro Arg Arg Leu  Thr Ala Thr 
    3200                 3205                 3210             


Gly Thr  Val Ile Val Ser Val  Leu Asp Ile Asn Asp  Asn Pro Pro 
    3215                 3220                 3225             


Val Phe  Glu Tyr Arg Glu Tyr  Gly Ala Thr Val Ser  Glu Asp Ile 
    3230                 3235                 3240             


Leu Val  Gly Thr Glu Val Leu  Gln Val Tyr Ala Ala  Ser Arg Asp 
    3245                 3250                 3255             


Ile Glu  Ala Asn Ala Glu Ile  Thr Tyr Ser Ile Ile  Ser Gly Asn 
    3260                 3265                 3270             


Glu His  Gly Lys Phe Ser Ile  Asp Ser Lys Thr Gly  Ala Val Phe 
    3275                 3280                 3285             


Ile Ile  Glu Asn Leu Asp Tyr  Glu Ser Ser His Glu  Tyr Tyr Leu 
    3290                 3295                 3300             


Thr Val  Glu Ala Thr Asp Gly  Gly Thr Pro Ser Leu  Ser Asp Val 
    3305                 3310                 3315             


Ala Thr  Val Asn Val Asn Val  Thr Asp Ile Asn Asp  Asn Thr Pro 
    3320                 3325                 3330             


Val Phe  Ser Gln Asp Thr Tyr  Thr Thr Val Ile Ser  Glu Asp Ala 
    3335                 3340                 3345             


Val Leu  Glu Gln Ser Val Ile  Thr Val Met Ala Asp  Asp Ala Asp 
    3350                 3355                 3360             


Gly Pro  Ser Asn Ser His Ile  His Tyr Ser Ile Ile  Asp Gly Asn 
    3365                 3370                 3375             


Gln Gly  Ser Ser Phe Thr Ile  Asp Pro Val Arg Gly  Glu Val Lys 
    3380                 3385                 3390             


Val Thr  Lys Leu Leu Asp Arg  Glu Thr Ile Ser Gly  Tyr Thr Leu 
    3395                 3400                 3405             


Thr Val  Gln Ala Ser Asp Asn  Gly Ser Pro Pro Arg  Val Asn Thr 
    3410                 3415                 3420             


Thr Thr  Val Asn Ile Asp Val  Ser Asp Val Asn Asp  Asn Ala Pro 
    3425                 3430                 3435             


Val Phe  Ser Arg Gly Asn Tyr  Ser Val Ile Ile Gln  Glu Asn Lys 
    3440                 3445                 3450             


Pro Val  Gly Phe Ser Val Leu  Gln Leu Val Val Thr  Asp Glu Asp 
    3455                 3460                 3465             


Ser Ser  His Asn Gly Pro Pro  Phe Phe Phe Thr Ile  Val Thr Gly 
    3470                 3475                 3480             


Asn Asp  Glu Lys Ala Phe Glu  Val Asn Pro Gln Gly  Val Leu Leu 
    3485                 3490                 3495             


Thr Ser  Ser Ala Ile Lys Arg  Lys Glu Lys Asp His  Tyr Leu Leu 
    3500                 3505                 3510             


Gln Val  Lys Val Ala Asp Asn  Gly Lys Pro Gln Leu  Ser Ser Leu 
    3515                 3520                 3525             


Thr Tyr  Ile Asp Ile Arg Val  Ile Glu Glu Ser Ile  Tyr Pro Pro 
    3530                 3535                 3540             


Ala Ile  Leu Pro Leu Glu Ile  Phe Ile Thr Ser Ser  Gly Glu Glu 
    3545                 3550                 3555             


Tyr Ser  Gly Gly Val Ile Gly  Lys Ile His Ala Thr  Asp Gln Asp 
    3560                 3565                 3570             


Val Tyr  Asp Thr Leu Thr Tyr  Ser Leu Asp Pro Gln  Met Asp Asn 
    3575                 3580                 3585             


Leu Phe  Ser Val Ser Ser Thr  Gly Gly Lys Leu Ile  Ala His Lys 
    3590                 3595                 3600             


Lys Leu  Asp Ile Gly Gln Tyr  Leu Leu Asn Val Ser  Val Thr Asp 
    3605                 3610                 3615             


Gly Lys  Phe Thr Thr Val Ala  Asp Ile Thr Val His  Ile Arg Gln 
    3620                 3625                 3630             


Val Thr  Gln Glu Met Leu Asn  His Thr Ile Ala Ile  Arg Phe Ala 
    3635                 3640                 3645             


Asn Leu  Thr Pro Glu Glu Phe  Val Gly Asp Tyr Trp  Arg Asn Phe 
    3650                 3655                 3660             


Gln Arg  Ala Leu Arg Asn Ile  Leu Gly Val Arg Arg  Asn Asp Ile 
    3665                 3670                 3675             


Gln Ile  Val Ser Leu Gln Ser  Ser Glu Pro His Pro  His Leu Asp 
    3680                 3685                 3690             


Val Leu  Leu Phe Val Glu Lys  Pro Gly Ser Ala Gln  Ile Ser Thr 
    3695                 3700                 3705             


Lys Gln  Leu Leu His Lys Ile  Asn Ser Ser Val Thr  Asp Ile Glu 
    3710                 3715                 3720             


Glu Ile  Ile Gly Val Arg Ile  Leu Asn Val Phe Gln  Lys Leu Cys 
    3725                 3730                 3735             


Ala Gly  Leu Asp Cys Pro Trp  Lys Phe Cys Asp Glu  Lys Val Ser 
    3740                 3745                 3750             


Val Asp  Glu Ser Val Met Ser  Thr His Ser Thr Ala  Arg Leu Ser 
    3755                 3760                 3765             


Phe Val  Thr Pro Arg His His  Arg Ala Ala Val Cys  Leu Cys Lys 
    3770                 3775                 3780             


Glu Gly  Arg Cys Pro Pro Val  His His Gly Cys Glu  Asp Asp Pro 
    3785                 3790                 3795             


Cys Pro  Glu Gly Ser Glu Cys  Val Ser Asp Pro Trp  Glu Glu Lys 
    3800                 3805                 3810             


His Thr  Cys Val Cys Pro Ser  Gly Arg Phe Gly Gln  Cys Pro Gly 
    3815                 3820                 3825             


Ser Ser  Ser Met Thr Leu Thr  Gly Asn Ser Tyr Val  Lys Tyr Arg 
    3830                 3835                 3840             


Leu Thr  Glu Asn Glu Asn Lys  Leu Glu Met Lys Leu  Thr Met Arg 
    3845                 3850                 3855             


Leu Arg  Thr Tyr Ser Thr His  Ala Val Val Met Tyr  Ala Arg Gly 
    3860                 3865                 3870             


Thr Asp  Tyr Ser Ile Leu Glu  Ile His His Gly Arg  Leu Gln Tyr 
    3875                 3880                 3885             


Lys Phe  Asp Cys Gly Ser Gly  Pro Gly Ile Val Ser  Val Gln Ser 
    3890                 3895                 3900             


Ile Gln  Val Asn Asp Gly Gln  Trp His Ala Val Ala  Leu Glu Val 
    3905                 3910                 3915             


Asn Gly  Asn Tyr Ala Arg Leu  Val Leu Asp Gln Val  His Thr Ala 
    3920                 3925                 3930             


Ser Gly  Thr Ala Pro Gly Thr  Leu Lys Thr Leu Asn  Leu Asp Asn 
    3935                 3940                 3945             


Tyr Val  Phe Phe Gly Gly His  Ile Arg Gln Gln Gly  Thr Arg His 
    3950                 3955                 3960             


Gly Arg  Ser Pro Gln Val Gly  Asn Gly Phe Arg Gly  Cys Met Asp 
    3965                 3970                 3975             


Ser Ile  Tyr Leu Asn Gly Gln  Glu Leu Pro Leu Asn  Ser Lys Pro 
    3980                 3985                 3990             


Arg Ser  Tyr Ala His Ile Glu  Glu Ser Val Asp Val  Ser Pro Gly 
    3995                 4000                 4005             


Cys Phe  Leu Thr Ala Thr Glu  Asp Cys Ala Ser Asn  Pro Cys Gln 
    4010                 4015                 4020             


Asn Gly  Gly Val Cys Asn Pro  Ser Pro Ala Gly Gly  Tyr Tyr Cys 
    4025                 4030                 4035             


Lys Cys  Ser Ala Leu Tyr Ile  Gly Thr His Cys Glu  Ile Ser Val 
    4040                 4045                 4050             


Asn Pro  Cys Ser Ser Lys Pro  Cys Leu Tyr Gly Gly  Thr Cys Val 
    4055                 4060                 4065             


Val Asp  Asn Gly Gly Phe Val  Cys Gln Cys Arg Gly  Leu Tyr Thr 
    4070                 4075                 4080             


Gly Gln  Arg Cys Gln Leu Ser  Pro Tyr Cys Lys Asp  Glu Pro Cys 
    4085                 4090                 4095             


Lys Asn  Gly Gly Thr Cys Phe  Asp Ser Leu Asp Gly  Ala Val Cys 
    4100                 4105                 4110             


Gln Cys  Asp Ser Gly Phe Arg  Gly Glu Arg Cys Gln  Ser Asp Ile 
    4115                 4120                 4125             


Asp Glu  Cys Ser Gly Asn Pro  Cys Leu His Gly Ala  Leu Cys Glu 
    4130                 4135                 4140             


Asn Thr  His Gly Ser Tyr His  Cys Asn Cys Ser His  Glu Tyr Arg 
    4145                 4150                 4155             


Gly Arg  His Cys Glu Asp Ala  Ala Pro Asn Gln Tyr  Val Ser Thr 
    4160                 4165                 4170             


Pro Trp  Asn Ile Gly Leu Ala  Glu Gly Ile Gly Ile  Val Val Phe 
    4175                 4180                 4185             


Val Ala  Gly Ile Phe Leu Leu  Val Val Val Phe Val  Leu Cys Arg 
    4190                 4195                 4200             


Lys Met  Ile Ser Arg Lys Lys  Lys His Gln Ala Glu  Pro Lys Asp 
    4205                 4210                 4215             


Lys His  Leu Gly Pro Ala Thr  Ala Phe Leu Gln Arg  Pro Tyr Phe 
    4220                 4225                 4230             


Asp Ser  Lys Leu Asn Lys Asn  Ile Tyr Ser Asp Ile  Pro Pro Gln 
    4235                 4240                 4245             


Val Pro  Val Arg Pro Ile Ser  Tyr Thr Pro Ser Ile  Pro Ser Asp 
    4250                 4255                 4260             


Ser Arg  Asn Asn Leu Asp Arg  Asn Ser Phe Glu Gly  Ser Ala Ile 
    4265                 4270                 4275             


Pro Glu  His Pro Glu Phe Ser  Thr Phe Asn Pro Glu  Ser Val His 
    4280                 4285                 4290             


Gly His  Arg Lys Ala Val Ala  Val Cys Ser Val Ala  Pro Asn Leu 
    4295                 4300                 4305             


Pro Pro  Pro Pro Pro Ser Asn  Ser Pro Ser Asp Ser  Asp Ser Ile 
    4310                 4315                 4320             


Gln Lys  Pro Ser Trp Asp Phe  Asp Tyr Asp Thr Lys  Val Val Asp 
    4325                 4330                 4335             


Leu Asp  Pro Cys Leu Ser Lys  Lys Pro Leu Glu Glu  Lys Pro Ser 
    4340                 4345                 4350             


Gln Pro  Tyr Ser Ala Arg Glu  Ser Leu Ser Glu Val  Gln Ser Leu 
    4355                 4360                 4365             


Ser Ser  Phe Gln Ser Glu Ser  Cys Asp Asp Asn Gly  Tyr His Trp 
    4370                 4375                 4380             


Asp Thr  Ser Asp Trp Met Pro  Ser Val Pro Leu Pro  Asp Ile Gln 
    4385                 4390                 4395             


Glu Phe  Pro Asn Tyr Glu Val  Ile Asp Glu Gln Thr  Pro Leu Tyr 
    4400                 4405                 4410             


Ser Ala  Asp Pro Asn Ala Ile  Asp Thr Asp Tyr Tyr  Pro Gly Gly 
    4415                 4420                 4425             


Tyr Asp  Ile Glu Ser Asp Phe  Pro Pro Pro Pro Glu  Asp Phe Pro 
    4430                 4435                 4440             


Ala Ala  Asp Glu Leu Pro Pro  Leu Pro Pro Glu Phe  Ser Asn Gln 
    4445                 4450                 4455             


Phe Glu  Ser Ile His Pro Pro  Arg Asp Met Pro Ala  Ala Gly Ser 
    4460                 4465                 4470             


Leu Gly  Ser Ser Ser Arg Asn  Arg Gln Arg Phe Asn  Leu Asn Gln 
    4475                 4480                 4485             


Tyr Leu  Pro Asn Phe Tyr Pro  Leu Asp Met Ser Glu  Pro Gln Thr 
    4490                 4495                 4500             


Lys Gly  Thr Gly Glu Asn Ser  Thr Cys Arg Glu Pro  His Ala Pro 
    4505                 4510                 4515             


Tyr Pro  Pro Gly Tyr Gln Arg  His Phe Glu Ala Pro  Ala Val Glu 
    4520                 4525                 4530             


Ser Met  Pro Met Ser Val Tyr  Ala Ser Thr Ala Ser  Cys Ser Asp 
    4535                 4540                 4545             


Val Ser  Ala Cys Cys Glu Val  Glu Ser Glu Val Met  Met Ser Asp 
    4550                 4555                 4560             


Tyr Glu  Ser Gly Asp Asp Gly  His Phe Glu Glu Val  Thr Ile Pro 
    4565                 4570                 4575             


Pro Leu  Asp Ser Gln Gln His  Thr Glu Val 
    4580                 4585             


<210>  2
<211>  488
<212>  PRT
<213>  Homo sapiens

<400>  2

Met Gly Arg His Leu Ala Leu Leu Leu Leu Leu Leu Leu Leu Phe Gln 
1               5                   10                  15      


His Phe Gly Asp Ser Asp Gly Ser Gln Arg Leu Glu Gln Thr Pro Leu 
            20                  25                  30          


Gln Phe Thr His Leu Glu Tyr Asn Val Thr Val Gln Glu Asn Ser Ala 
        35                  40                  45              


Ala Lys Thr Tyr Val Gly His Pro Val Lys Met Gly Val Tyr Ile Thr 
    50                  55                  60                  


His Pro Ala Trp Glu Val Arg Tyr Lys Ile Val Ser Gly Asp Ser Glu 
65                  70                  75                  80  


Asn Leu Phe Lys Ala Glu Glu Tyr Ile Leu Gly Asp Phe Cys Phe Leu 
                85                  90                  95      


Arg Ile Arg Thr Lys Gly Gly Asn Thr Ala Ile Leu Asn Arg Glu Val 
            100                 105                 110         


Lys Asp His Tyr Thr Leu Ile Val Lys Ala Leu Glu Lys Asn Thr Asn 
        115                 120                 125             


Val Glu Ala Arg Thr Lys Val Arg Val Gln Val Leu Asp Thr Asn Asp 
    130                 135                 140                 


Leu Arg Pro Leu Phe Ser Pro Thr Ser Tyr Ser Val Ser Leu Pro Glu 
145                 150                 155                 160 


Asn Thr Ala Ile Arg Thr Ser Ile Ala Arg Val Ser Ala Thr Asp Ala 
                165                 170                 175     


Asp Ile Gly Thr Asn Gly Glu Phe Tyr Tyr Ser Phe Lys Asp Arg Thr 
            180                 185                 190         


Asp Met Phe Ala Ile His Pro Thr Ser Gly Val Ile Val Leu Thr Gly 
        195                 200                 205             


Arg Leu Asp Tyr Leu Glu Thr Lys Leu Tyr Glu Met Glu Ile Leu Ala 
    210                 215                 220                 


Ala Asp Arg Gly Met Lys Leu Tyr Gly Ser Ser Gly Ile Ser Ser Met 
225                 230                 235                 240 


Ala Lys Leu Thr Val His Ile Glu Gln Ala Asn Glu Cys Ala Pro Val 
                245                 250                 255     


Ile Thr Ala Val Thr Leu Ser Pro Ser Glu Leu Asp Arg Asp Pro Ala 
            260                 265                 270         


Tyr Ala Ile Val Thr Val Asp Asp Cys Asp Gln Gly Ala Asn Gly Asp 
        275                 280                 285             


Ile Ala Ser Leu Ser Ile Val Ala Gly Asp Leu Leu Gln Gln Phe Arg 
    290                 295                 300                 


Thr Val Arg Ser Phe Pro Gly Ser Lys Glu Tyr Lys Val Lys Ala Ile 
305                 310                 315                 320 


Gly Gly Ile Asp Trp Asp Ser His Pro Phe Gly Tyr Asn Leu Thr Leu 
                325                 330                 335     


Gln Ala Lys Asp Lys Gly Thr Pro Pro Gln Phe Ser Ser Val Lys Val 
            340                 345                 350         


Ile His Val Thr Ser Pro Gln Phe Lys Ala Gly Pro Val Lys Phe Glu 
        355                 360                 365             


Lys Asp Val Tyr Arg Ala Glu Ile Ser Glu Phe Ala Pro Pro Asn Thr 
    370                 375                 380                 


Pro Val Val Met Val Lys Ala Ile Pro Ala Tyr Ser His Leu Arg Tyr 
385                 390                 395                 400 


Val Phe Lys Ser Thr Pro Gly Lys Ala Lys Phe Ser Leu Asn Tyr Asn 
                405                 410                 415     


Thr Gly Leu Ile Ser Ile Leu Glu Pro Val Lys Arg Gln Gln Ala Ala 
            420                 425                 430         


His Phe Glu Leu Glu Val Thr Thr Ser Asp Arg Lys Ala Ser Thr Lys 
        435                 440                 445             


Val Leu Val Lys Val Leu Gly Ala Asn Ser Asn Pro Pro Glu Phe Thr 
    450                 455                 460                 


Gln Thr Ala Tyr Lys Ala Ala Phe Asp Glu Asn Val Pro Ile Gly Thr 
465                 470                 475                 480 


Thr Val Met Ser Leu Ser Ala Val 
                485             


<210>  3
<211>  368
<212>  PRT
<213>  Homo sapiens


<220>
<221>  misc_feature
<222>  (1)..(1)
<223>  Xaa can be any naturally occurring amino acid

<400>  3

Xaa Asp Ser Lys Leu Asn Lys Asn Ile Tyr Ser Asp Ile Pro Pro Gln 
1               5                   10                  15      


Val Pro Val Arg Pro Ile Ser Tyr Thr Pro Ser Ile Pro Ser Asp Ser 
            20                  25                  30          


Arg Asn Asn Leu Asp Arg Asn Ser Phe Glu Gly Ser Ala Ile Pro Glu 
        35                  40                  45              


His Pro Glu Phe Ser Thr Phe Asn Pro Glu Ser Val His Gly His Arg 
    50                  55                  60                  


Lys Ala Val Ala Val Cys Ser Val Ala Pro Asn Leu Pro Pro Pro Pro 
65                  70                  75                  80  


Pro Ser Asn Ser Pro Ser Asp Ser Asp Ser Ile Gln Lys Pro Ser Trp 
                85                  90                  95      


Asp Phe Asp Tyr Asp Thr Lys Val Val Asp Leu Asp Pro Cys Leu Ser 
            100                 105                 110         


Lys Lys Pro Leu Glu Glu Lys Pro Ser Gln Pro Tyr Ser Ala Arg Glu 
        115                 120                 125             


Ser Leu Ser Glu Val Gln Ser Leu Ser Ser Phe Gln Ser Glu Ser Cys 
    130                 135                 140                 


Asp Asp Asn Glu Ser Leu Ala Ala Pro Asp Leu Ser Lys Pro Arg Gly 
145                 150                 155                 160 


Tyr His Trp Asp Thr Ser Asp Trp Met Pro Ser Val Pro Leu Pro Asp 
                165                 170                 175     


Ile Gln Glu Phe Pro Asn Tyr Glu Val Ile Asp Glu Gln Thr Pro Leu 
            180                 185                 190         


Tyr Ser Ala Asp Pro Asn Ala Ile Asp Thr Asp Tyr Tyr Pro Gly Gly 
        195                 200                 205             


Tyr Asp Ile Glu Ser Asp Phe Pro Pro Pro Pro Glu Asp Phe Pro Ala 
    210                 215                 220                 


Ala Asp Glu Leu Pro Pro Leu Pro Pro Glu Phe Ser Asn Gln Phe Glu 
225                 230                 235                 240 


Ser Ile His Pro Pro Arg Asp Met Pro Ala Ala Gly Ser Leu Gly Ser 
                245                 250                 255     


Ser Ser Arg Asn Arg Gln Arg Phe Asn Leu Asn Gln Tyr Leu Pro Asn 
            260                 265                 270         


Phe Tyr Pro Leu Asp Met Ser Glu Pro Gln Thr Lys Gly Thr Gly Glu 
        275                 280                 285             


Asn Ser Thr Cys Arg Glu Pro His Ala Pro Tyr Pro Pro Gly Tyr Gln 
    290                 295                 300                 


Arg His Phe Glu Ala Pro Ala Val Glu Ser Met Pro Met Ser Val Tyr 
305                 310                 315                 320 


Ala Ser Thr Ala Ser Cys Ser Asp Val Ser Ala Cys Cys Glu Val Glu 
                325                 330                 335     


Ser Glu Val Met Met Ser Asp Tyr Glu Ser Gly Asp Asp Gly His Phe 
            340                 345                 350         


Glu Glu Val Thr Ile Pro Pro Leu Asp Ser Gln Gln His Thr Glu Val 
        355                 360                 365             


<210>  4
<211>  285
<212>  PRT
<213>  Homo sapiens


<220>
<221>  misc_feature
<222>  (1)..(1)
<223>  Xaa can be any naturally occurring amino acid

<400>  4

Xaa Ser Thr Thr Glu Ala Leu Phe Ala Ser Val Glu Asp Tyr Ile Leu 
1               5                   10                  15      


Val Arg Gly Val Ser Leu Val His Thr Ala Lys Met Asn Pro Val Arg 
            20                  25                  30          


Met Ala Glu His Ala Leu Thr Val Trp Met Ala Pro Phe Val Ser Val 
        35                  40                  45              


Ile Arg Val Leu Gly Glu Lys Gly Val Arg Val Ile Ser Thr Ser Ala 
    50                  55                  60                  


Leu Glu Thr Leu Ala Cys Thr Gly Pro Ser Val Arg Thr Arg Thr Ala 
65                  70                  75                  80  


Pro Ile Thr Ala Thr Ala Ala Thr Ser Thr Gly Asp Val Thr Ala Arg 
                85                  90                  95      


Met Leu Arg Pro Thr Thr Lys Val Val Asp Leu Asp Pro Cys Leu Ser 
            100                 105                 110         


Lys Lys Pro Leu Glu Glu Lys Pro Ser Gln Pro Tyr Ser Ala Arg Glu 
        115                 120                 125             


Ser Leu Ser Glu Val Gln Ser Leu Ser Ser Phe Gln Ser Glu Ser Cys 
    130                 135                 140                 


Asp Asp Asn Gly Tyr His Trp Asp Thr Ser Asp Trp Met Pro Ser Val 
145                 150                 155                 160 


Pro Leu Pro Asp Ile Gln Glu Phe Pro Asn Tyr Glu Val Ile Asp Glu 
                165                 170                 175     


Gln Thr Pro Leu Tyr Ser Ala Asp Pro Asn Ala Ile Asp Thr Asp Tyr 
            180                 185                 190         


Tyr Pro Gly Gly Tyr Asp Ile Glu Ser Asp Phe Pro Pro Pro Pro Glu 
        195                 200                 205             


Asp Phe Pro Ala Ala Asp Glu Leu Pro Pro Leu Pro Pro Glu Phe Ser 
    210                 215                 220                 


Asn Gln Phe Glu Ser Ile His Pro Pro Arg Asp Met Pro Ala Ala Gly 
225                 230                 235                 240 


Ser Leu Gly Ser Ser Ser Arg Asn Arg Gln Arg Phe Asn Leu Asn Gln 
                245                 250                 255     


Tyr Leu Pro Asn Phe Tyr Pro Leu Asp Met Ser Glu Pro Gln Thr Lys 
            260                 265                 270         


Gly Thr Gly Glu Asn Ser Thr Cys Arg Glu Pro His Ala 
        275                 280                 285 


<210>  5
<211>  119
<212>  PRT
<213>  Homo sapiens

<400>  5

Leu Ser Lys Lys Pro Leu Glu Glu Lys Pro Ser Gln Pro Tyr Ser Ala 
1               5                   10                  15      


Arg Glu Ser Leu Ser Glu Val Gln Ser Leu Ser Ser Phe Gln Ser Glu 
            20                  25                  30          


Ser Cys Asp Asp Asn Ala Ser Ile Val Thr Val Met His Leu Val Asn 
        35                  40                  45              


Ala Val Val Asp Thr Val Ser Thr Glu Glu Ser Leu Ala Ala Pro Asp 
    50                  55                  60                  


Leu Ser Lys Pro Arg Gly Tyr His Trp Asp Thr Ser Asp Trp Met Pro 
65                  70                  75                  80  


Ser Val Pro Leu Pro Asp Ile Gln Glu Phe Pro Asn Tyr Glu Val Ile 
                85                  90                  95      


Asp Glu Gln Thr Pro Leu Tyr Ser Ala Asp Pro Asn Ala Ile Asp Thr 
            100                 105                 110         


Asp Tyr Tyr Pro Gly Gly Tyr 
        115                 


<210>  6
<211>  14786
<212>  DNA
<213>  Homo sapiens

<400>  6
agcgtgaggc gccggcgccg agctgggcgg ccgggcgcgg ggagagggcg cgggagcggc       60

tcgtgcggca ggtaccatgc ggacgcgcga gcccggcgag ggccccggca ggcccggtcc      120

ctgctcgggg gcgcgctgag acggcgggtg agctccacga gagcgccgtc gccacttcgg      180

gccaactttg cgattcccga cagttaagca atggggagac atttggcttt gctcctgctt      240

ctgctccttc tcttccaaca ttttggagac agtgatggca gccaacgact tgaacagact      300

cctctgcagt ttacacacct cgagtacaac gtcaccgtgc aggagaactc tgcagctaag      360

acttatgtgg ggcatcctgt caagatgggt gtttacatta cacatccagc gtgggaagta      420

aggtacaaaa ttgtttccgg agacagtgaa aacctgttca aagctgaaga gtacattctc      480

ggagactttt gctttctaag aataaggacc aaaggaggaa atacagctat tcttaataga      540

gaagtgaagg atcactacac attgatagtg aaagcacttg aaaaaaatac taatgtggag      600

gcgcgaacaa aggtcagggt gcaggtgctg gatacaaatg acttgagacc gttattctca      660

cccacctcat acagcgtttc tttacctgaa aacacagcta taaggaccag tatcgcaaga      720

gtcagcgcca cggatgcaga cataggaacc aacggggaat tttactacag ttttaaagat      780

cgaacagata tgtttgctat tcacccaacc agtggtgtga tagtgttaac tggtagactt      840

gattacctag agaccaagct ctatgagatg gaaatcctcg ctgcggaccg tggcatgaag      900

ttgtatggga gcagtggcat cagcagcatg gccaagctaa cggtgcacat cgaacaggcc      960

aatgaatgtg ctccggtgat aacagcagtg acattgtcac catcagaact ggacagggac     1020

ccagcatatg caattgtgac agtggatgac tgcgatcagg gtgccaatgg tgacatagca     1080

tctttaagca tcgtggcagg tgaccttctc cagcagttta gaacagtgag gtcctttcca     1140

gggagtaagg agtataaagt caaagccatc ggtggcattg attgggacag tcatcctttc     1200

ggctacaatc tcacactaca ggctaaagat aaaggaactc cgccccagtt ctcttctgtt     1260

aaagtcattc acgtgacttc tccacagttc aaagccgggc cagtcaagtt tgaaaaggat     1320

gtttacagag cagaaataag tgaatttgct cctcccaaca cacctgtggt catggtaaag     1380

gccattcctg cttattccca tttgaggtat gtttttaaaa gtacacctgg aaaagctaaa     1440

ttcagtttaa attacaacac tggtctcatt tctattttag aaccagttaa aagacagcag     1500

gcagcccatt ttgaacttga agtaacaaca agtgacagaa aagcgtccac caaggtcttg     1560

gtgaaagtct taggtgcaaa tagcaatccc cctgaattta cccagacagc gtacaaagct     1620

gcttttgatg agaacgtgcc cattggtact actgtcatga gcctgagtgc cgtagaccct     1680

gatgagggtg agaacgggta cgtgacatac agtatcgcaa atttaaatca tgtgccgttt     1740

gcgattgacc atttcactgg tgccgtgagt acgtcagaaa acctggacta cgaactgatg     1800

cctcgggttt atactctgag gattcgtgca tcagactggg gcttgccgta ccgccgggaa     1860

gtcgaagtcc ttgctacaat tactctcaat aacttgaatg acaacacacc tttgtttgag     1920

aaaataaatt gtgaagggac aattcccaga gatctaggcg tgggagagca aataaccact     1980

gtttctgcta ttgatgcaga tgaacttcag ttggtacagt atcagattga agctggaaat     2040

gaactggatt tctttagttt aaaccccaac tcgggggtat tgtcattaaa gcgatcgcta     2100

atggatggct taggtgcaaa ggtgtctttc cacagtctga gaatcacagc tacagatgga     2160

gaaaattttg ccacaccatt atatatcaac ataacagtgg ctgccagtca caagctggta     2220

aacttgcagt gtgaagagac tggtgttgcc aaaatgctgg cagagaagct cctgcaggca     2280

aataaattac acaaccaggg agaggtggag gatattttct tcgattctca ctctgtcaat     2340

gctcacatac cgcagtttag aagcactctt ccgactggta ttcaggtaaa ggaaaaccag     2400

cctgtgggtt ccagtgtaat tttcatgaac tccactgacc ttgacactgg cttcaatgga     2460

aaactggtct atgctgtttc tggaggaaat gaggatagtt gcttcatgat tgatatggaa     2520

acaggaatgc tgaaaatttt atctcctctt gaccgtgaaa caacagacaa atacaccctg     2580

aatattaccg tctatgacct tgggataccc cagaaggctg cgtggcgtct tctacatgtc     2640

gtggttgtcg atgccaatga taatccaccc gagtttttac aggagagcta ttttgtggaa     2700

gtgagtgaag acaaggaggt acatagtgaa atcatccagg ttgaagccac agataaagac     2760

ctggggccca acggacacgt gacgtactca attgttacag acacagacac attttcaatt     2820

gacagcgtga cgggtgttgt taacatcgca cgccctctgg atcgagagct gcagcatgag     2880

cactccttaa agattgaggc cagggaccaa gccagagaag agcctcagct gttctccact     2940

gtcgttgtga aagtatcact agaagatgtt aatgacaacc cacctacatt tattccacct     3000

aattatcgtg tgaaagtccg agaggatctt ccagaaggaa ccgtcatcat gtggttagaa     3060

gcccacgatc ctgatttagg tcagtctggt caggtgagat acagccttct ggaccacgga     3120

gaaggaaact tcgatgtgga taaactcagt ggagcagtta ggatcgtcca gcagttggac     3180

tttgagaaga agcaagtgta taatctcact gtgagggcca aagacaaggg aaagccagtt     3240

tctctgtctt ctacttgcta tgttgaagtt gaggtggttg atgtgaatga gaacctgcac     3300

ccacccgtgt tttccagctt tgtggaaaag gggacagtga aagaagatgc acctgttggt     3360

tcattggtaa tgacggtgtc ggctcatgat gaggacgcca gaagagatgg ggagatccga     3420

tactccatta gagatggctc tggcgttggt gttttcaaaa taggtgaaga gacaggtgtc     3480

atagagacgt cagatcgact ggaccgtgaa tcgacctccc attattggct aacagtcttt     3540

gcaaccgatc agggtgtcgt gcctctttca tcgttcatag agatctacat agaggttgag     3600

gatgtcaatg acaatgcacc acagacatca gagcctgttt attacccaga aatcatggaa     3660

aattctccta aagatgtatc tgtggtccag atcgaggcat ttgatccaga ttcgagctct     3720

aatgacaagc tcatgtacaa aattacaagt ggaaatccac aaggattctt ttcaatacat     3780

cctaaaacag gtctcatcac aactacgtca aggaagctag accgagaaca gcaagatgaa     3840

cacatattag aggttactgt gacagacaat ggtagtcccc ccaaatcaac cattgcaaga     3900

gtcattgtga aaatccttga tgaaaatgac aacaaacctc agtttctgca aaagttctac     3960

aaaatcagac tccctgagcg ggaaaagcca gaccgagaaa gaaatgccag acgggagccg     4020

ctctatcacg tcatagccac cgacaaggat gagggcccca atgcagaaat ctcctacagc     4080

atcgaagacg ggaatgagca tggcaaattt ttcatcgaac cgaaaactgg agtggtttcg     4140

tccaagaggt tttcagcagc tggagaatat gatattcttt caattaaggc agttgacaat     4200

ggtcgccctc aaaagtcatc aaccaccaga ctccatattg aatggatctc caagcccaaa     4260

ccgtccctgg agcccatttc atttgaagaa tcatttttta cctttactgt gatggaaagt     4320

gaccccgttg ctcacatgat tggagtaata tctgtggagc ctcctggcat acccctttgg     4380

tttgacatca ctggtggcaa ctacgacagt cacttcgatg tggacaaggg aactggaacc     4440

atcattgttg ccaaacctct tgatgcagaa cagaagtcaa actacaacct cacagtcgag     4500

gctacagatg gaaccaccac tatcctcact caggtattca tcaaagtaat agacacaaat     4560

gaccatcgtc ctcagttttc tacatcaaag tatgaagttg ttattcctga agatacagcg     4620

ccagaaacag aaattttgca aatcagtgct gtggatcagg atgagaaaaa caaactaatc     4680

tacactctgc agagcagtag agatccactg agtctcaaga aatttcgtct tgatcctgca     4740

accggctctc tctatacttc tgagaaactg gatcatgaag ctgttcacca gcacaccctc     4800

acggtcatgg tacgagatca agatgtgcct gtaaaacgca actttgcaag gattgtggtc     4860

aatgtcagcg acacgaatga ccacgccccg tggttcaccg cttcctccta caaagggcgg     4920

gtttatgaat cggcagccgt tggctcagtt gtgttgcagg tgacggctct ggacaaggac     4980

aaagggaaaa atgctgaagt gctgtactcg atcgagtcag gaaatattgg aaattctttt     5040

atgattgatc ctgtcttggg ctctattaaa actgccaaag aattagatcg aagtaaccaa     5100

gcggagtatg atttaatggt aaaagctaca gataagggca gtccaccaat gagtgaaata     5160

acttctgtgc gtatctttgt cacaattgct gacaacgcct ctccgaagtt tacatcaaaa     5220

gaatattctg ttgaacttag tgaaactgtc agcattggga gtttcgttgg gatggttaca     5280

gcccatagtc aatcatcagt ggtgtatgaa ataaaagatg gaaatacagg tgatgctttt     5340

gatattaatc cacattctgg aactatcatc actcagaaag ccctggactt tgaaactttg     5400

cccatttaca cattgataat acaaggaact aacatggctg gtttgtccac taatacaacg     5460

gttctagttc acttgcagga tgagaatgac aacgcgccag tttttatgca ggcagaatat     5520

acaggactca ttagtgaatc agcctcaatt aacagcgtgg tcctaacaga caggaatgtc     5580

ccactggtga ttcgagcagc tgatgctgat aaagactcaa atgctttgct tgtatatcac     5640

attgttgaac catctgtaca cacatatttt gctattgatt ctagcactgg tgctattcat     5700

acagtactaa gtctggacta tgaagaaaca agtatttttc actttaccgt ccaagtgcat     5760

gacatgggaa ccccacgttt atttgctgag tatgcagcga atgtaacagt acatgtaatt     5820

gacattaatg actgcccccc tgtgtttgcc aagccattat atgaagcatc tcttttgtta     5880

ccaacataca aaggagtaaa agtcatcaca gtaaatgcta cagatgctga ttcaagtgca     5940

ttctcacagt tgatttactc catcaccgaa ggcaacatcg gggagaagtt ttctatggac     6000

tacaagactg gtgctctcac tgtccaaaac acaactcagt taagaagccg ctacgagcta     6060

accgttagag cttccgatgg cagatttgcc ggccttacct ctgtcaaaat taatgtgaaa     6120

gaaagcaaag aaagtcacct aaagtttacc caggatgtct actctgcggt agtgaaagag     6180

aattccaccg aggccgaaac attagctgtc attactgcta ttgggaatcc aatcaatgag     6240

cctttgtttt atcacatcct caacccagat cgcagattta aaataagccg cacttcagga     6300

gttctgtcaa ccactggcac gcccttcgat cgtgagcagc aggaggcgtt tgatgtggtt     6360

gtagaagtga cagaggaaca taagccttct gcagtggccc acgttgtcgt gaaggtcatt     6420

gtagaagacc aaaatgataa tgcgccggtg tttgtcaacc ttccctacta cgccgttgtt     6480

aaagtggaca ctgaggtggg ccatgtcatt cgctatgtca ctgctgtaga cagagacagt     6540

ggcagaaacg gggaagtgca ttactacctc aaggaacatc atgaacactt tcaaattgga     6600

cccttgggtg aaatttcact gaaaaagcaa tttgagcttg acaccttaaa taaagaatat     6660

cttgttacag tggttgcaaa agatggaggg aacccggcct tttcagcgga agttatcgtt     6720

ccgatcactg tcatgaataa agccatgcct gtgtttgaaa aacctttcta cagtgcagag     6780

attgcagaga gcatccaggt gcacagccct gtggtccacg tgcaggctaa cagcccggaa     6840

ggcctgaaag tgttctacag catcacagac ggagaccctt tcagccagtt cactattaac     6900

ttcaatactg gagttatcaa tgtcatagct cctctggact ttgaggccca cccggcatat     6960

aagctgagca tacgcgcaac tgactccttg acgggcgctc atgctgaagt atttgtggac     7020

atcatagtag acgacatcaa tgataaccct cctgtgtttg ctcagcagtc ttatgcggtg     7080

accctgtctg aggcatctgt aattggaacg tctgttgttc aagttagagc caccgattct     7140

gattcagaac caaatagagg aatctcatac cagatgtttg ggaatcacag caagagtcat     7200

gatcattttc atgtagacag cagcactggc ctcatctcac tactcagaac cctggattac     7260

gagcagtccc ggcagcacac gatttttgtg agggcagttg atggtggtat gcccacgctg     7320

agcagtgatg tgattgtcac ggtggacgtt accgacctca atgataatcc accactcttt     7380

gaacaacaga tttatgaagc cagaattagc gagcacgccc ctcatgggca tttcgtgacc     7440

tgtgtaaaag cctatgatgc agacagttca gacatagaca agttgcagta ttccattctg     7500

tctggcaatg atcataaaca ttttgtcatt gacagtgcaa cagggattat caccctctca     7560

aacctgcacc ggcacgccct gaagccattt tacagtctta acctgtcagt gtctgatgga     7620

gtttttagaa gttccaccca ggttcatgta actgtaattg gaggcaattt gcacagtcct     7680

gctttccttc agaacgaata tgaagtggaa ctagctgaaa acgctcccct acataccctg     7740

gtgatggagg tgaaaactac ggatggggat tctggtattt atggtcacgt tacttaccat     7800

attgtaaatg actttgccaa agacagattt tacataaatg agagaggaca gatatttact     7860

ttggaaaaac ttgatcgaga aaccccggcg gagaaagtga tctcagtccg tttaatggct     7920

aaggatgctg gaggaaaagt tgctttctgc accgtgaatg tcatccttac agatgacaat     7980

gacaatgcac cacaatttcg agcaaccaaa tacgaagtga atatcgggtc cagtgctgct     8040

aaagggactt cagtcgttaa agttcttgca agtgatgccg atgagggctc caatgccgac     8100

atcacctatg ccattgaagc agactctgaa agtgtaaaag agaatttgga aattaacaaa     8160

ctgtccggcg taatcactac aaaggagagc ctcattggct tggaaaatga attcttcact     8220

ttctttgtta gagctgtgga taatgggtct ccatcaaaag aatctgttgt tcttgtctat     8280

gttaaaatcc ttccaccgga aatgcagctt ccaaaatttt cagaaccttt ctataccttt     8340

acagtgtcag aggacgtgcc tattggaaca gagatagatc tcatccgagc agaacatagt     8400

gggactgttc tttacagcct ggtcaaaggg aatactccag aaagcaatag ggatgagtcc     8460

tttgtgattg acagacagag cgggagactg aagttggaga agagtcttga tcatgagaca     8520

actaagtggt atcagttttc catactggcc aggtgcactc aagatgacca tgagatggtg     8580

gcttctgtag atgttagtat ccaagtgaaa gatgcaaatg acaacagccc ggtctttgaa     8640

tctagtccat atgaggcatt cattgttgaa aacctgccag ggggaagtag agtaattcag     8700

atcagggcat ctgatgctga ctcaggaacc aacggccaag ttatgtatag cctggatcag     8760

tcacaaagtg tggaagtcat tgaatccttt gccattaaca tggaaacagg ctggattaca     8820

actttaaagg aacttgacca tgaaaagaga gacaattacc agattaaagt ggttgcatca     8880

gatcatggtg aaaagatcca gctatcctcc acagccattg tggatgttac cgtcaccgat     8940

gtcaacgata gtccaccacg attcacggcc gagatctata aagggactgt gagtgaggat     9000

gacccccaag gtggggtgat tgccatctta agtaccacgg atgctgattc tgaagagatc     9060

aacagacaag ttacatattt cataacagga ggggatcctt taggacagtt tgccgttgaa     9120

actatacaga atgaatggaa ggtatatgtg aagaaacctc tagacaggga aaaaagggac     9180

aattaccttc ttactatcac ggcaactgat ggcaccttct catcaaaagc gatagttgaa     9240

gtgaaagttc tggatgcaaa tgacaacagt ccagtttgtg aaaagacttt atattcagac     9300

actattcctg aagacgtcct tcctggaaaa ttgatcatgc agatctctgc tacagacgca     9360

gacatccgct ctaacgctga aattacttac acgttattgg gttcaggtgc agaaaaattc     9420

aaactaaatc cagacacagg tgaactgaaa acgtcaaccc cccttgatcg tgaggagcaa     9480

gctgtttatc atcttctcgt cagggccaca gatggaggag gaagattctg ccaagccagt     9540

attgtgctca cgctagaaga tgtgaacgat aacgcccccg aattctctgc cgatccttat     9600

gccatcaccg tgtttgaaaa cacagagccg ggaacgctgc tgacaagagt gcaggccaca     9660

gatgccgacg caggattaaa tcggaagatt ttatactcac tgattgactc tgctgatggg     9720

cagttctcca ttaacgaatt atctggaatt attcagttag aaaaaccttt ggacagagaa     9780

ctccaggcag tatacaccct ctctttgaaa gctgtggatc aaggcttgcc aaggaggctg     9840

actgccactg gcactgtgat tgtatcagtt cttgacataa atgacaaccc ccctgtgttt     9900

gagtaccgtg aatatggtgc caccgtgtct gaggacattc ttgttggaac tgaagttctt     9960

caagtgtatg cagcaagtcg ggatattgaa gcaaatgcag aaatcaccta ctcaataata    10020

agtggaaatg aacatgggaa attcagcata gattctaaaa caggggccgt atttatcatt    10080

gagaatctgg attatgagag ctctcatgag tattacctaa cagtagaggc cactgatgga    10140

ggcacgcctt cactgagcga cgttgccact gtgaacgtta atgtaacaga tatcaacgat    10200

aatacccctg tgttcagcca agacacctac acgacagtca tcagtgaaga tgccgttctt    10260

gagcagtctg tcatcacggt tatggccgat gatgccgatg gaccttccaa cagccacatc    10320

cactactcaa ttatagatgg caaccaagga agctcgttca caattgaccc cgtcagggga    10380

gaagtcaaag tgaccaaact tctcgaccga gaaacgattt caggttacac gctcacggtt    10440

caagcttctg ataatggcag tccacccaga gtcaacacga cgaccgtgaa catcgatgtg    10500

tccgatgtca atgacaacgc gcccgtcttc tccaggggaa actacagtgt cattatccag    10560

gaaaataagc cagtgggctt cagcgtgctg cagctggtag taacagatga ggattcttcc    10620

cataacggtc cacccttctt ctttactatt gtaactggaa atgatgagaa ggcttttgaa    10680

gttaacccgc aaggagtcct cctgacatca tctgccatca agaggaagga gaaagatcat    10740

tacttactgc aggtgaaggt ggcagataat ggaaagcctc agttgtcatc tttgacatac    10800

attgacatta gggtaattga ggagagcatc tatccgcctg cgattttgcc cctggagatt    10860

ttcatcacct cttctggaga agaatactca ggtggcgtca ttgggaagat ccatgccaca    10920

gaccaggacg tgtatgatac tctaacctac agtctcgacc ctcagatgga caacctgttc    10980

tctgtttcca gcacaggggg caagctgata gcacacaaaa agctagacat agggcaatac    11040

cttctcaatg tcagcgtaac agatgggaag ttcacgacgg tggccgacat cacagtgcat    11100

atcagacaag tcacacagga gatgttgaac cacaccatcg cgatccgctt tgccaacctc    11160

actccggaag aattcgttgg tgactactgg cgcaacttcc agcgagcttt acggaacatc    11220

ctgggtgtga ggaggaacga catacagatt gttagtttgc agtcctctga acctcaccca    11280

catctggacg tcttactttt tgtagagaaa ccaggtagtg ctcagatctc aacaaaacaa    11340

cttctgcaca agattaactc ttccgtgact gacattgagg aaatcattgg agttaggata    11400

ctgaatgtat tccagaaact ctgcgcggga ctggactgcc cctggaagtt ctgcgatgaa    11460

aaggtgtctg tggatgaaag tgtgatgtca acacacagca cagccagact gagttttgtg    11520

actccccgcc accacagggc agcggtgtgt ctctgcaaag agggaaggtg cccacctgtc    11580

caccatggct gtgaagatga tccgtgccct gagggatccg aatgtgtgtc tgatccctgg    11640

gaggagaaac acacctgtgt ctgtcccagc ggcaggtttg gtcagtgccc agggagttca    11700

tctatgacac tgactggaaa cagctacgtg aaataccgtc tgacggaaaa tgaaaacaaa    11760

ttagagatga aactgaccat gaggctcaga acatattcca cgcatgcggt tgtcatgtat    11820

gctcgaggaa ctgactatag catcttggag attcatcatg gaaggctgca gtacaagttt    11880

gactgtggaa gtggccctgg aattgtctct gttcagagca ttcaggtcaa tgatgggcag    11940

tggcacgcag tggccctgga agtgaatgga aactatgctc gcttggttct agaccaagtt    12000

catactgcat cgggcacagc cccagggact ctgaaaaccc tgaacctgga taactatgtg    12060

ttttttggtg gccacatccg tcagcaggga acaaggcatg gaagaagtcc tcaagttggt    12120

aatggtttca ggggttgtat ggactccatt tatttgaatg ggcaggagct ccctttaaac    12180

agcaaaccca gaagctatgc acacatcgaa gagtcggtgg atgtatctcc aggctgcttc    12240

ctgacggcca cggaagactg cgccagcaac ccttgccaga atggaggcgt ttgcaatccg    12300

tcacctgctg gaggttatta ctgcaaatgc agtgccttgt acatagggac ccactgtgag    12360

ataagcgtca atccgtgttc ctccaagcca tgcctctatg ggggcacgtg tgttgtcgac    12420

aacggaggct ttgtttgcca gtgtagagga ttatatactg gtcagaggtg tcagcttagt    12480

ccatactgca aagatgaacc ctgtaagaat ggcggaacat gctttgacag tttggatggc    12540

gccgtttgtc agtgtgattc gggttttagg ggagaaaggt gtcagagtga tatcgacgag    12600

tgctctggaa acccttgcct gcacggggcc ctctgtgaga acacgcacgg ctcctatcac    12660

tgcaactgca gccacgagta caggggacgt cactgcgagg atgctgcgcc caaccagtat    12720

gtgtccacgc cgtggaacat tgggttggcg gaaggaattg gaatcgttgt gtttgttgca    12780

gggatatttt tactggtggt ggtgtttgtt ctctgccgta agatgattag tcggaaaaag    12840

aagcatcagg ctgaacctaa agacaagcac ctgggacccg ctacggcttt cttgcaaaga    12900

ccgtattttg attccaagct aaataagaac atttactcag acataccacc ccaggtgcct    12960

gtccggccta tttcctacac cccgagtatt ccaagtgact caagaaacaa tctggaccga    13020

aattccttcg aaggatctgc tatcccagag catcccgaat tcagcacttt taaccccgag    13080

tctgtgcacg ggcaccgaaa agcagtggcg gtctgcagcg tggcgccaaa cctgcctccc    13140

ccaccccctt caaactcccc ttctgacagc gactccatcc agaagcctag ctgggacttt    13200

gactatgaca caaaagtggt ggatcttgat ccctgtcttt ccaagaagcc tctagaggaa    13260

aagccttccc agccatacag tgcccgggaa agcctgtctg aagtgcagtc tctgagctcc    13320

ttccagtccg aatcgtgcga tgacaatggg tatcactggg atacatcaga ttggatgcca    13380

agcgttcctc tgccggacat acaagagttc cccaactatg aggtgattga tgagcagaca    13440

cccctgtact cagcagatcc aaacgccatc gatacggact attaccctgg aggctacgac    13500

atcgaaagtg attttcctcc acccccagaa gacttccccg cagctgatga gctaccaccg    13560

ttaccgcccg aattcagcaa tcagtttgaa tccatccacc ctcctagaga catgcctgcc    13620

gcgggtagct tgggttcttc atcaagaaac cggcagaggt tcaacttgaa tcagtatttg    13680

cccaattttt atcccctcga tatgtctgaa cctcaaacaa aaggcactgg tgagaatagt    13740

acttgtagag aaccccatgc cccttacccg ccagggtatc aaagacactt cgaggcgccc    13800

gctgtcgaga gcatgcccat gtctgtgtac gcctccaccg cctcctgctc tgacgtgtca    13860

gcctgctgcg aagtggagtc cgaggtcatg atgagtgact atgagagcgg ggacgacggc    13920

cacttcgaag aggtgacgat cccgcccctg gattcccagc agcacacgga agtctgactc    13980

tcaactcccc ccaaagtgcc tgactttagt gaacctagag gtgatgtgag taatccgcgc    14040

tgttctttgc agcagtgctt ccaagctttt tttggtgagc cgaatgggca tggctgcgct    14100

ggatcctgcg cctctggacg tgctagccat ttccagtgtc ccaactactg tcatcgtgag    14160

gttttcatcg gctgtgccat ttcccaacgt cttttgggat ttacatctgt ctgtgttaaa    14220

ataatcaaac gaaaaatcag tcctgtgttg tcagcatgat tcatgtattt atatagattt    14280

gattatttta attttcctgt ctcttttttt tgtaaatttt atgtacagat ttgatttttc    14340

atagttttaa ctagatttcc aagatatttt gtgcatttgt ttcaactgaa ttttggtggt    14400

gtcagtgcca ttatctagca ccctgatttt ttttttttta ctataaccag ggtttcattc    14460

tgtctttttc cactgaagtg tgacattttg ttagtacatt tcagtgtagt cattcatttc    14520

tagctgtaca taggatgaag gagagatcag atacatgaac atgtcttaca tgggttgctg    14580

tatttagaat tataaacatt tttcattatt ggaaagtgta acggggacct tctgcatacc    14640

tgtttagaac caaaaccacc atgacacagt ttttatagtg tctgtatatt tgtgatgcaa    14700

tggtcttgta aaggttttta atgaaaacta ccattagcca gtctttctta ctgacaataa    14760

attattaata aaatacttga gcttta                                         14786


<210>  7
<211>  1852
<212>  DNA
<213>  Homo sapiens

<400>  7
aagggggagg gagtggggaa agaggcagcg agtcgccgca gccggcggcc gcaactcctc       60

aactcggcgg ctggctgcct gggcacgtcc tgacaaactt ggctgctccc gggccctcgt      120

tccggccccg cgcactctct tttcgcctgc gtttggtgct taagtttgcc ctggtcggaa      180

gcctccggag atgcggccgc ctgggtcccg gcggcacgga cgttggcact ctggttaggg      240

acatgctgaa gatcccgggg aggcaaagtt ggtacttcaa acccggctct taacacatat      300

ctacaccgcg aggggatcac ggagctgccg aggactttag agcccagggc cgaggactcg      360

gctagactga ttcccgacag ttaagcaatg gggagacatt tggctttgct cctgcttctg      420

ctccttctct tccaacattt tggagacagt gatggcagcc aacgacttga acagactcct      480

ctgcagttta cacacctcga gtacaacgtc accgtgcagg agaactctgc agctaagact      540

tatgtggggc atcctgtcaa gatgggtgtt tacattacac atccagcgtg ggaagtaagg      600

tacaaaattg tttccggaga cagtgaaaac ctgttcaaag ctgaagagta cattctcgga      660

gacttttgct ttctaagaat aaggaccaaa ggaggaaata cagctattct taatagagaa      720

gtgaaggatc actacacatt gatagtgaaa gcacttgaaa aaaatactaa tgtggaggcg      780

cgaacaaagg tcagggtgca ggtgctggat acaaatgact tgagaccgtt attctcaccc      840

acctcataca gcgtttcttt acctgaaaac acagctataa ggaccagtat cgcaagagtc      900

agcgccacgg atgcagacat aggaaccaac ggggaatttt actacagttt taaagatcga      960

acagatatgt ttgctattca cccaaccagt ggtgtgatag tgttaactgg tagacttgat     1020

tacctagaga ccaagctcta tgagatggaa atcctcgctg cggaccgtgg catgaagttg     1080

tatgggagca gtggcatcag cagcatggcc aagctaacgg tgcacatcga acaggccaat     1140

gaatgtgctc cggtgataac agcagtgaca ttgtcaccat cagaactgga cagggaccca     1200

gcatatgcaa ttgtgacagt ggatgactgc gatcagggtg ccaatggtga catagcatct     1260

ttaagcatcg tggcaggtga ccttctccag cagtttagaa cagtgaggtc ctttccaggg     1320

agtaaggagt ataaagtcaa agccatcggt ggcattgatt gggacagtca tcctttcggc     1380

tacaatctca cactacaggc taaagataaa ggaactccgc cccagttctc ttctgttaaa     1440

gtcattcacg tgacttctcc acagttcaaa gccgggccag tcaagtttga aaaggatgtt     1500

tacagagcag aaataagtga atttgctcct cccaacacac ctgtggtcat ggtaaaggcc     1560

attcctgctt attcccattt gaggtatgtt tttaaaagta cacctggaaa agctaaattc     1620

agtttaaatt acaacactgg tctcatttct attttagaac cagttaaaag acagcaggca     1680

gcccattttg aacttgaagt aacaacaagt gacagaaaag cgtccaccaa ggtcttggtg     1740

aaagtcttag gtgcaaatag caatccccct gaatttaccc agacagcgta caaagctgct     1800

tttgatgaga acgtgcccat tggtactact gtcatgagcc tgagtgccgt ag             1852


<210>  8
<211>  1305
<212>  DNA
<213>  Homo sapiens

<400>  8
tgattccaag ctaaataaga acatttactc agacatacca ccccaggtgc ctgtccggcc       60

tatttcctac accccgagta ttccaagtga ctcaagaaac aatctggacc gaaattcctt      120

cgaaggatct gctatcccag agcatcccga attcagcact tttaaccccg agtctgtgca      180

cgggcaccga aaagcagtgg cggtctgcag cgtggcgcca aacctgcctc ccccaccccc      240

ttcaaactcc ccttctgaca gcgactccat ccagaagcct agctgggact ttgactatga      300

cacaaaagtg gtggatcttg atccctgtct ttccaagaag cctctagagg aaaagccttc      360

ccagccatac agtgcccggg aaagcctgtc tgaagtgcag tctctgagct ccttccagtc      420

cgaatcgtgc gatgacaatg aatctttggc tgctcctgac ctcagcaaac caagagggta      480

tcactgggat acatcagatt ggatgccaag cgttcctctg ccggacatac aagagttccc      540

caactatgag gtgattgatg agcagacacc cctgtactca gcagatccaa acgccatcga      600

tacggactat taccctggag gctacgacat cgaaagtgat tttcctccac ccccagaaga      660

cttccccgca gctgatgagc taccaccgtt accgcccgaa ttcagcaatc agtttgaatc      720

catccaccct cctagagaca tgcctgccgc gggtagcttg ggttcttcat caagaaaccg      780

gcagaggttc aacttgaatc agtatttgcc caatttttat cccctcgata tgtctgaacc      840

tcaaacaaaa ggcactggtg agaatagtac ttgtagagaa ccccatgccc cttacccgcc      900

agggtatcaa agacacttcg aggcgcccgc tgtcgagagc atgcccatgt ctgtgtacgc      960

ctccaccgcc tcctgctctg acgtgtcagc ctgctgcgaa gtggagtccg aggtcatgat     1020

gagtgactat gagagcgggg acgacggcca cttcgaagag gtgacgatcc cgcccctgga     1080

ttcccagcag cacacggaag tctgactctc aactcccccc aaagtgcctg actttagtga     1140

acctagaggt gatgtgagta atccgcgctg ttctttgcag cagtgcttcc aagctttttt     1200

tggtgagccg aatgggcatg gctgcgctgg atcctgcgcc tctggacgtg ctagccattt     1260

ccagtgtccc aactactgtc atcgtgaggt tttcatcggc tgtgc                     1305


<210>  9
<211>  854
<212>  DNA
<213>  Homo sapiens

<400>  9
gtcgacaacg gaggctttgt ttgccagtgt agaggattat atactggtca gaggtgtcag       60

cttagtccat actgcaaaga tgaaccctgt aagaatggcg gaacatgctt tgacagtttg      120

gatggcgccg tttgtcagtg tgattcgggt tttaggggag aaaggtgtca gagtgatatc      180

gacgagtgct ctggaaaccc ttgcctgcac ggggccctct gtgagaacac gcacggctcc      240

tatcactgca actgcagcca cgagtacagg ggacgtcact gcgaggatgc tgcgcccaac      300

cacaaaagtg gtggatcttg atccctgtct ttccaagaag cctctagagg aaaagccttc      360

ccagccatac agtgcccggg aaagcctgtc tgaagtgcag tctctgagct ccttccagtc      420

cgaatcgtgc gatgacaatg ggtatcactg ggatacatca gattggatgc caagcgttcc      480

tctgccggac atacaagagt tccccaacta tgaggtgatt gatgagcaga cacccctgta      540

ctcagcagat ccaaacgcca tcgatacgga ctattaccct ggaggctacg acatcgaaag      600

tgattttcct ccacccccag aagacttccc cgcagctgat gagctaccac cgttaccgcc      660

cgaattcagc aatcagtttg aatccatcca ccctcctaga gacatgcctg ccgcgggtag      720

cttgggttct tcatcaagaa accggcagag gttcaacttg aatcagtatt tgcccaattt      780

ttatcccctc gatatgtctg aacctcaaac aaaaggcact ggtgagaata gtacttgtag      840

agaaccccat gccc                                                        854


<210>  10
<211>  357
<212>  DNA
<213>  Homo sapiens

<400>  10
ctttccaaga agcctctaga ggaaaagcct tcccagccat acagtgcccg ggaaagcctg       60

tctgaagtgc agtctctgag ctccttccag tccgaatcgt gcgatgacaa tgcttccata      120

gtgaccgtaa tgcaccttgt caatgctgtg gttgacacgg tgagcacaga agaatctttg      180

gctgctcctg acctcagcaa accaagaggg tatcactggg atacatcaga ttggatgcca      240

agcgttcctc tgccggacat acaagagttc cccaactatg aggtgattga tgagcagaca      300

cccctgtact cagcagatcc aaacgccatc gatacggact attaccctgg aggctac         357


<210>  11
<211>  30
<212>  DNA
<213>  Homo sapiens

<400>  11
ggctacacat tcaccaggtc ctggatgcac                                        30


<210>  12
<211>  24
<212>  DNA
<213>  Homo sapiens

<400>  12
atttatcctg gtagtggtgg tact                                              24


<210>  13
<211>  30
<212>  DNA
<213>  Homo sapiens

<400>  13
acaagatcag ggggtcagag gttcgactac                                        30


<210>  14
<211>  30
<212>  DNA
<213>  Homo sapiens

<400>  14
agtgccagct caagtgtaag ttccatgcac                                        30


<210>  15
<211>  21
<212>  DNA
<213>  Homo sapiens

<400>  15
gacacatcca aactggcttc t                                                 21


<210>  16
<211>  27
<212>  DNA
<213>  Homo sapiens

<400>  16
tttcagggga gtgggtatcc attcacg                                           27


<210>  17
<211>  8
<212>  PRT
<213>  Homo sapiens

<400>  17

Gly Tyr Thr Phe Thr Arg Ser Trp 
1               5               


<210>  18
<211>  8
<212>  PRT
<213>  Homo sapiens

<400>  18

Ile Tyr Pro Gly Ser Gly Gly Thr 
1               5               


<210>  19
<211>  10
<212>  PRT
<213>  Homo sapiens

<400>  19

Thr Arg Ser Gly Gly Gln Arg Phe Asp Tyr 
1               5                   10  


<210>  20
<211>  10
<212>  PRT
<213>  Homo sapiens

<400>  20

Ser Ala Ser Ser Ser Val Ser Ser Met His 
1               5                   10  


<210>  21
<211>  7
<212>  PRT
<213>  Homo sapiens

<400>  21

Asp Thr Ser Lys Leu Ala Ser 
1               5           


<210>  22
<211>  9
<212>  PRT
<213>  Homo sapiens

<400>  22

Phe Gln Gly Ser Gly Tyr Pro Phe Thr 
1               5                   


<210>  23
<211>  372
<212>  DNA
<213>  Homo sapiens

<400>  23
gttcagctgc agcagtctgg gtctgagctg gtgaggcctg gagcttcagt gaagctgtcc       60

tgcaaggctt ctggctacac attcaccagg tcctggatgc actggataaa gcagaggcct      120

ggacaaggcc ttgaatggat tggaaatatt tatcctggta gtggtggtac taactacgat      180

gagaagttca agagcaaggc cacactgact gtagacacgt cctccagcac agcctacatg      240

cagctcagca gcctgacatc tgaggactct gcgatctatt actgtacaag atcagggggt      300

cagaggttcg actactgggg ccaaggcacc actctcacag tctcctcagc caaaacgaca      360

cccccatctg tc                                                          372


<210>  24
<211>  338
<212>  DNA
<213>  Homo sapiens

<400>  24
attgtgatga cccagtctcc agcaatcatg tctgcatttt caggggaaaa ggtcaccatg       60

acctgcagtg ccagctcaag tgtaagttcc atgcactggt accagcagaa gtcaagcacc      120

tcccccaaat tctggattta tgacacatcc aaactggctt ctggagtccc aggtcgcttc      180

agtggcagtg ggtctggaaa ctcttactct ctcacgatca gcagcatgga ggctgaagat      240

gttgccactt attactgttt tcaggggagt gggtatccat tcacgttcgg aggggggacc      300

aagctggaaa taaaacgggc tgatgctgca ccaattgt                              338


<210>  25
<211>  124
<212>  PRT
<213>  Homo sapiens

<400>  25

Val Gln Leu Gln Gln Ser Gly Ser Glu Leu Val Arg Pro Gly Ala Ser 
1               5                   10                  15      


Val Lys Leu Ser Cys Lys Ala Ser Gly Tyr Thr Phe Thr Arg Ser Trp 
            20                  25                  30          


Met His Trp Ile Lys Gln Arg Pro Gly Gln Gly Leu Glu Trp Ile Gly 
        35                  40                  45              


Asn Ile Tyr Pro Gly Ser Gly Gly Thr Asn Tyr Asp Glu Lys Phe Lys 
    50                  55                  60                  


Ser Lys Ala Thr Leu Thr Val Asp Thr Ser Ser Ser Thr Ala Tyr Met 
65                  70                  75                  80  


Gln Leu Ser Ser Leu Thr Ser Glu Asp Ser Ala Ile Tyr Tyr Cys Thr 
                85                  90                  95      


Arg Ser Gly Gly Gln Arg Phe Asp Tyr Trp Gly Gln Gly Thr Thr Leu 
            100                 105                 110         


Thr Val Ser Ser Ala Lys Thr Thr Pro Pro Ser Val 
        115                 120                 


<210>  26
<211>  112
<212>  PRT
<213>  Homo sapiens

<400>  26

Ile Val Met Thr Gln Ser Pro Ala Ile Met Ser Ala Phe Ser Gly Glu 
1               5                   10                  15      


Lys Val Thr Met Thr Cys Ser Ala Ser Ser Ser Val Ser Ser Met His 
            20                  25                  30          


Trp Tyr Gln Gln Lys Ser Ser Thr Ser Pro Lys Phe Trp Ile Tyr Asp 
        35                  40                  45              


Thr Ser Lys Leu Ala Ser Gly Val Pro Gly Arg Phe Ser Gly Ser Gly 
    50                  55                  60                  


Ser Gly Asn Ser Tyr Ser Leu Thr Ile Ser Ser Met Glu Ala Glu Asp 
65                  70                  75                  80  


Val Ala Thr Tyr Tyr Cys Phe Gln Gly Ser Gly Tyr Pro Phe Thr Phe 
                85                  90                  95      


Gly Gly Gly Thr Lys Leu Glu Ile Lys Arg Ala Asp Ala Ala Pro Ile 
            100                 105                 110         


<210>  27
<211>  630
<212>  PRT
<213>  Homo sapiens

<400>  27

Gly Ile Gln Val Lys Glu Asn Gln Pro Val Gly Ser Ser Val Ile Phe 
1               5                   10                  15      


Met Asn Ser Thr Asp Leu Asp Thr Gly Phe Asn Gly Lys Leu Val Tyr 
            20                  25                  30          


Ala Val Ser Gly Gly Asn Glu Asp Ser Cys Phe Met Ile Asp Met Glu 
        35                  40                  45              


Thr Gly Met Leu Lys Ile Leu Ser Pro Leu Asp Arg Glu Thr Thr Asp 
    50                  55                  60                  


Lys Tyr Thr Leu Asn Ile Thr Val Tyr Asp Leu Gly Ile Pro Gln Lys 
65                  70                  75                  80  


Ala Ala Trp Arg Leu Leu His Val Val Val Val Asp Ala Asn Asp Asn 
                85                  90                  95      


Pro Pro Glu Phe Leu Gln Glu Ser Tyr Phe Val Glu Val Ser Glu Asp 
            100                 105                 110         


Lys Glu Val His Ser Glu Ile Ile Gln Val Glu Ala Thr Asp Lys Asp 
        115                 120                 125             


Leu Gly Pro Asn Gly His Val Thr Tyr Ser Ile Val Thr Asp Thr Asp 
    130                 135                 140                 


Thr Phe Ser Ile Asp Ser Val Thr Gly Val Val Asn Ile Ala Arg Pro 
145                 150                 155                 160 


Leu Asp Arg Glu Leu Gln His Glu His Ser Leu Lys Ile Glu Ala Arg 
                165                 170                 175     


Asp Gln Ala Arg Glu Glu Pro Gln Leu Phe Ser Thr Val Val Val Lys 
            180                 185                 190         


Val Ser Leu Glu Asp Val Asn Asp Asn Pro Pro Thr Phe Ile Pro Pro 
        195                 200                 205             


Asn Tyr Arg Val Lys Val Arg Glu Asp Leu Pro Glu Gly Thr Val Ile 
    210                 215                 220                 


Met Trp Leu Glu Ala His Asp Pro Asp Leu Gly Gln Ser Gly Gln Val 
225                 230                 235                 240 


Arg Tyr Ser Leu Leu Asp His Gly Glu Gly Asn Phe Asp Val Asp Lys 
                245                 250                 255     


Leu Ser Gly Ala Val Arg Ile Val Gln Gln Leu Asp Phe Glu Lys Lys 
            260                 265                 270         


Gln Val Tyr Asn Leu Thr Val Arg Ala Lys Asp Lys Gly Lys Pro Val 
        275                 280                 285             


Ser Leu Ser Ser Thr Cys Tyr Val Glu Val Glu Val Val Asp Val Asn 
    290                 295                 300                 


Glu Asn Leu His Pro Pro Val Phe Ser Ser Phe Val Glu Lys Gly Thr 
305                 310                 315                 320 


Val Lys Glu Asp Ala Pro Val Gly Ser Leu Val Met Thr Val Ser Ala 
                325                 330                 335     


His Asp Glu Asp Ala Arg Arg Asp Gly Glu Ile Arg Tyr Ser Ile Arg 
            340                 345                 350         


Asp Gly Ser Gly Val Gly Val Phe Lys Ile Gly Glu Glu Thr Gly Val 
        355                 360                 365             


Ile Glu Thr Ser Asp Arg Leu Asp Arg Glu Ser Thr Ser His Tyr Trp 
    370                 375                 380                 


Leu Thr Val Phe Ala Thr Asp Gln Gly Val Val Pro Leu Ser Ser Phe 
385                 390                 395                 400 


Ile Glu Ile Tyr Ile Glu Val Glu Asp Val Asn Asp Asn Ala Pro Gln 
                405                 410                 415     


Thr Ser Glu Pro Val Tyr Tyr Pro Glu Ile Met Glu Asn Ser Pro Lys 
            420                 425                 430         


Asp Val Ser Val Val Gln Ile Glu Ala Phe Asp Pro Asp Ser Ser Ser 
        435                 440                 445             


Asn Asp Lys Leu Met Tyr Lys Ile Thr Ser Gly Asn Pro Gln Gly Phe 
    450                 455                 460                 


Phe Ser Ile His Pro Lys Thr Gly Leu Ile Thr Thr Thr Ser Arg Lys 
465                 470                 475                 480 


Leu Asp Arg Glu Gln Gln Asp Glu His Ile Leu Glu Val Thr Val Thr 
                485                 490                 495     


Asp Asn Gly Ser Pro Pro Lys Ser Thr Ile Ala Arg Val Ile Val Lys 
            500                 505                 510         


Ile Leu Asp Glu Asn Asp Asn Lys Pro Gln Phe Leu Gln Lys Phe Tyr 
        515                 520                 525             


Lys Ile Arg Leu Pro Glu Arg Glu Lys Pro Asp Arg Glu Arg Asn Ala 
    530                 535                 540                 


Arg Arg Glu Pro Leu Tyr His Val Ile Ala Thr Asp Lys Asp Glu Gly 
545                 550                 555                 560 


Pro Asn Ala Glu Ile Ser Tyr Ser Ile Glu Asp Gly Asn Glu His Gly 
                565                 570                 575     


Lys Phe Phe Ile Glu Pro Lys Thr Gly Val Val Ser Ser Lys Arg Phe 
            580                 585                 590         


Ser Ala Ala Gly Glu Tyr Asp Ile Leu Ser Ile Lys Ala Val Asp Asn 
        595                 600                 605             


Gly Arg Pro Gln Lys Ser Ser Thr Thr Arg Leu His Ile Glu Trp Ile 
    610                 615                 620                 


Ser Lys Pro Lys Pro Ser 
625                 630 


<210>  28
<211>  98
<212>  PRT
<213>  Homo sapiens

<400>  28

Ser Tyr Phe Val Glu Val Ser Glu Asp Lys Glu Val His Ser Glu Ile 
1               5                   10                  15      


Ile Gln Val Glu Ala Thr Asp Lys Asp Leu Gly Pro Asn Gly His Val 
            20                  25                  30          


Thr Tyr Ser Ile Val Thr Asp Thr Asp Thr Phe Ser Ile Asp Ser Val 
        35                  40                  45              


Thr Gly Val Val Asn Ile Ala Arg Pro Leu Asp Arg Glu Leu Gln His 
    50                  55                  60                  


Glu His Ser Leu Lys Ile Glu Ala Arg Asp Gln Ala Arg Glu Glu Pro 
65                  70                  75                  80  


Gln Leu Phe Ser Thr Val Val Val Lys Val Ser Leu Glu Asp Val Asn 
                85                  90                  95      


Asp Asn 
        


<210>  29
<211>  95
<212>  PRT
<213>  Homo sapiens

<400>  29

Tyr Lys Ile Arg Leu Pro Glu Arg Glu Lys Pro Asp Arg Glu Arg Asn 
1               5                   10                  15      


Ala Arg Arg Glu Pro Leu Tyr His Val Ile Ala Thr Asp Lys Asp Glu 
            20                  25                  30          


Gly Pro Asn Ala Glu Ile Ser Tyr Ser Ile Glu Asp Gly Asn Glu His 
        35                  40                  45              


Gly Lys Phe Phe Ile Glu Pro Lys Thr Gly Val Val Ser Ser Lys Arg 
    50                  55                  60                  


Phe Ser Ala Ala Gly Glu Tyr Asp Ile Leu Ser Ile Lys Ala Val Asp 
65                  70                  75                  80  


Asn Gly Arg Pro Gln Lys Ser Ser Thr Thr Arg Leu His Ile Glu 
                85                  90                  95  


<210>  30
<211>  25
<212>  PRT
<213>  Homo sapiens

<400>  30

Arg Glu Pro Leu Tyr His Val Ile Ala Thr Asp Lys Asp Glu Gly Pro 
1               5                   10                  15      


Asn Ala Glu Ile Ser Tyr Ser Ile Glu 
            20                  25  


<210>  31
<211>  25
<212>  PRT
<213>  Homo sapiens

<400>  31

Tyr His Val Ile Ala Thr Asp Lys Asp Glu Gly Pro Asn Ala Glu Ile 
1               5                   10                  15      


Ser Tyr Ser Ile Glu Asp Gly Asn Glu 
            20                  25  


<210>  32
<211>  25
<212>  PRT
<213>  Homo sapiens

<400>  32

Ile Gln Val Glu Ala Thr Asp Lys Asp Leu Gly Pro Asn Gly His Val 
1               5                   10                  15      


Thr Tyr Ser Ile Val Thr Asp Thr Asp 
            20                  25  


<210>  33
<211>  336
<212>  DNA
<213>  Unknown

<220>
<223>  hybridoma

<400>  33
cagtcagggt ctgggctggt gaggcctgga acttcagtga agctgtcctg caaggcttct       60

ggtttcacat tcaccagcaa ctggatgcac tgggtgaaac agaggcctgg acaaggcctt      120

gattggatcg gaaatattta tcctggtagt ggtaaaacta attacggtga gaagttcaag      180

agcaaggcca cactgactgt tgacacatcc tccagcacag cctacattca gctcagcagc      240

ctgacatctg aggactctgc ggtctattac tgtacaagat ctgggggtca gaggttcgac      300

tattggggcc aaggcaccac tctcacagtc tcctca                                336


<210>  34
<211>  306
<212>  DNA
<213>  Unknown

<220>
<223>  hybridoma

<400>  34
cagtctccag caatcatgtc tgcatttaca ggggaaaagg tcaccatgac ctgcagtgcc       60

agctcaagtg tagcttgcat gcactggtac cagcagaagt caagcacctc ccccaaactc      120

ttgatttatg acacatccga actggcttct ggagtcccag gtcgcttcag tggcagtggg      180

tctggaaact cttactctct cacgatcagc agcatggagg ctgaagatgt tgccacttat      240

tactgttttc aggggagtgg gtacccactc acgttcggag gggggaccaa gctggaaata      300

aaacgg                                                                 306


<210>  35
<211>  112
<212>  PRT
<213>  Unknown

<220>
<223>  hybridoma

<400>  35

Gln Ser Gly Ser Gly Leu Val Arg Pro Gly Thr Ser Val Lys Leu Ser 
1               5                   10                  15      


Cys Lys Ala Ser Gly Phe Thr Phe Thr Ser Asn Trp Met His Trp Val 
            20                  25                  30          


Lys Gln Arg Pro Gly Gln Gly Leu Asp Trp Ile Gly Asn Ile Tyr Pro 
        35                  40                  45              


Gly Ser Gly Lys Thr Asn Tyr Gly Glu Lys Phe Lys Ser Lys Ala Thr 
    50                  55                  60                  


Leu Thr Val Asp Thr Ser Ser Ser Thr Ala Tyr Ile Gln Leu Ser Ser 
65                  70                  75                  80  


Leu Thr Ser Glu Asp Ser Ala Val Tyr Tyr Cys Thr Arg Ser Gly Gly 
                85                  90                  95      


Gln Arg Phe Asp Tyr Trp Gly Gln Gly Thr Thr Leu Thr Val Ser Ser 
            100                 105                 110         


<210>  36
<211>  102
<212>  PRT
<213>  Unknown

<220>
<223>  hybridoma

<400>  36

Gln Ser Pro Ala Ile Met Ser Ala Phe Thr Gly Glu Lys Val Thr Met 
1               5                   10                  15      


Thr Cys Ser Ala Ser Ser Ser Val Ala Cys Met His Trp Tyr Gln Gln 
            20                  25                  30          


Lys Ser Ser Thr Ser Pro Lys Leu Leu Ile Tyr Asp Thr Ser Glu Leu 
        35                  40                  45              


Ala Ser Gly Val Pro Gly Arg Phe Ser Gly Ser Gly Ser Gly Asn Ser 
    50                  55                  60                  


Tyr Ser Leu Thr Ile Ser Ser Met Glu Ala Glu Asp Val Ala Thr Tyr 
65                  70                  75                  80  


Tyr Cys Phe Gln Gly Ser Gly Tyr Pro Leu Thr Phe Gly Gly Gly Thr 
                85                  90                  95      


Lys Leu Glu Ile Lys Arg 
            100         


<210>  37
<211>  8
<212>  PRT
<213>  Unknown

<220>
<223>  hybridoma

<400>  37

Gly Phe Thr Phe Thr Ser Asn Trp 
1               5               


<210>  38
<211>  8
<212>  PRT
<213>  Unknown

<220>
<223>  hybridoma

<400>  38

Ile Tyr Pro Gly Ser Gly Lys Thr 
1               5               


<210>  39
<211>  10
<212>  PRT
<213>  Unknown

<220>
<223>  hybridoma

<400>  39

Thr Arg Ser Gly Gly Gln Arg Phe Asp Tyr 
1               5                   10  


<210>  40
<211>  10
<212>  PRT
<213>  Unknown

<220>
<223>  hybridoma

<400>  40

Ser Ala Ser Ser Ser Val Ala Cys Met His 
1               5                   10  


<210>  41
<211>  7
<212>  PRT
<213>  Unknown

<220>
<223>  hybridoma

<400>  41

Asp Thr Ser Glu Leu Ala Ser 
1               5           


<210>  42
<211>  9
<212>  PRT
<213>  Unknown

<220>
<223>  hybridoma

<400>  42

Phe Gln Gly Ser Gly Tyr Pro Leu Thr 
1               5                   


<210>  43
<211>  21
<212>  DNA
<213>  Homo sapiens

<400>  43
caggacgtgt atgatactct a                                                 21


<210>  44
<211>  21
<212>  DNA
<213>  Homo sapiens

<400>  44
caggctggat tacaacttta a                                                 21


<210>  45
<211>  27
<212>  DNA
<213>  Unknown

<220>
<223>  synthetic oligonucleotide

<400>  45
atagacagat gggggtgtcg ttttggc                                           27


<210>  46
<211>  21
<212>  DNA
<213>  Unknown

<220>
<223>  synthetic oligonucleotide

<400>  46
ggatacagtt ggtgcagcat c                                                 21


<210>  47
<211>  20
<212>  DNA
<213>  Unknown

<220>
<223>  synthetic oligonucleotide


<220>
<221>  misc_feature
<222>  (1)..(1)
<223>  C or G

<220>
<221>  misc_feature
<222>  (3)..(3)
<223>  A or G

<220>
<221>  misc_feature
<222>  (6)..(6)
<223>  any base (not a gap)

<220>
<221>  misc_feature
<222>  (7)..(7)
<223>  amino A or C

<220>
<221>  misc_feature
<222>  (13)..(13)
<223>  C or G

<220>
<221>  misc_feature
<222>  (16)..(16)
<223>  C or G

<400>  47
nangtnnagc tgnagnagtc                                                   20


<210>  48
<211>  23
<212>  DNA
<213>  Unknown

<220>
<223>  synthetic oligonucleotide


<220>
<221>  misc_feature
<222>  (1)..(1)
<223>  C or G

<220>
<221>  misc_feature
<222>  (3)..(3)
<223>  A or G

<220>
<221>  misc_feature
<222>  (6)..(6)
<223>  any base (not a gap)

<220>
<221>  misc_feature
<222>  (7)..(7)
<223>  amino (A or C)

<220>
<221>  misc_feature
<222>  (13)..(13)
<223>  A or C

<220>
<221>  misc_feature
<222>  (16)..(16)
<223>  A or C

<220>
<221>  misc_feature
<222>  (21)..(21)
<223>  A or T

<400>  48
nangtnnagc tgnagnagtc ngg                                               23


<210>  49
<211>  24
<212>  DNA
<213>  Unknown

<220>
<223>  synthetic oligonucleotide


<220>
<221>  misc_feature
<222>  (3)..(3)
<223>  C or T

<220>
<221>  misc_feature
<222>  (10)..(10)
<223>  amino(A or C)

<220>
<221>  misc_feature
<222>  (12)..(12)
<223>  C or G

<220>
<221>  misc_feature
<222>  (15)..(15)
<223>  amino(A or C)

<220>
<221>  misc_feature
<222>  (18)..(18)
<223>  A or G

<220>
<221>  misc_feature
<222>  (19)..(19)
<223>  A or T

<220>
<221>  misc_feature
<222>  (22)..(22)
<223>  amino(A or C)

<220>
<221>  misc_feature
<222>  (22)..(22)
<223>  A or C

<400>  49
ganattgtgn tnacncarnc tnca                                              24


