                         SEQUENCE LISTING

<110>  INSERM
 
<120>  METHODS AND PHARMACEUTICAL COMPOSITIONS FOR THE TREATMENT OF 
       ERYTHROPOIETIC PROTOPORPHYRIA

<130>  BIO 12380 GOUYA / MC

<160>  57    

<170>  PatentIn version 3.3

<210>  1
<211>  7277
<212>  DNA
<213>  Homo sapiens

<400>  1
aggtcagggg gctggggacg cgcgtgggga tcgctacccg gctcggccac tgctgggcgg     60

acacctgggc gcgccgccgc gggaggagcc cggactcggg ccgaggctgc ccaggcaatg    120

cgttcactcg gcgcaaacat ggctgcggcc ctgcgcgccg cgggcgtcct gctccgcgat    180

ccgctggcat ccagcagctg gagggtctgt cagccatgga ggtggaagtc aggtgcagct    240

gcagcggccg tcaccacaga aacagcccag catgcccagg gtgcaaaacc tcaagttcaa    300

ccgcagaaga ggaagccgaa aactggaata ttaatgctaa acatgggagg ccctgaaact    360

cttggagatg ttcacgactt ccttctgaga ctcttcttgg accgagacct catgacactt    420

cctattcaga ataagctggc accattcatc gccaaacgcc gaacccccaa gattcaagag    480

cagtaccgca ggattggagg cggatccccc atcaagatat ggacttccaa gcagggagag    540

ggcatggtga agctgctgga tgaattgtcc cccaacacag cccctcacaa atactatatt    600

ggatttcggt acgtccatcc tttaacagaa gaagcaattg aagagatgga gagagatggc    660

ctagaaaggg ctattgcttt cacacagtat ccacagtaca gctgctccac cacaggcagc    720

agcttaaatg ccatttacag atactataat caagtgggac ggaagcccac gatgaagtgg    780

agcactattg acaggtggcc cacacatcac ctcctcatcc agtgctttgc agatcatatt    840

ctaaaggaac tggaccattt tccacttgag aagagaagcg aggtggtcat tctgttttct    900

gctcactcac tgcccatgtc tgtggtcaac agaggcgacc catatcctca ggaggtaagc    960

gccactgtcc aaaaagtcat ggaaaggctg gagtactgca acccctaccg actggtgtgg   1020

caatccaagg ttggtccaat gccctggttg ggtcctcaaa cagacgaatc tatcaaaggg   1080

ctttgtgaga gggggaggaa gaatatcctc ttggttccga tagcatttac cagtgaccat   1140

attgaaacgc tgtatgagct ggacatcgag tactctcaag ttttagccaa ggagtgtgga   1200

gttgaaaaca tcagaagagc tgagtctctt aatggaaatc cattgttctc taaggccctg   1260

gccgacttgg tgcattcaca catccagtca aacgagctgt gttccaagca gctgaccctg   1320

agctgtccgc tctgtgtcaa tcctgtctgc agggagacta aatccttctt caccagccag   1380

cagctgtgac ccccgccggt ggaccccgtg gcgttaggca aatgcccaac ctccagatac   1440

ctccgatgtg gagagggtgt tatttagaga tcaaggaagg aagtcatcct tccttgatat   1500

atatacagcc tttgggtaca aattgtgtgg tttcttgagg attggactct tgatggattt   1560

ctatttttat ataactatac agtaagcatt tgtattttct ctctctaggt ataagttact   1620

agtttggaat gtccatcagg acctttaata aatgagttaa aaatttgtct tatgagacac   1680

acctatttaa gtacagattt tggctttatt gcccaaaacc ctcctgaaag ggtacggaga   1740

gtcccctctg tgggctggca gtgtgaatga gatctgttta gtctcgtgca tatagttgct   1800

gttttttaaa tgaacacagt tgagtatttg aagtgaattt gaaaaagaaa tgttacttaa   1860

tctttcccta agcccatggg ttacagaatg ctagggaggc aatttggtta cctgcaatgg   1920

ctgcttttgc cagcgaggcc accattcatt ggtcatcttg gtatttgtgt gtgaatctca   1980

ctttcctcaa tgtaaaaagg aatcaagtat ggatttcaga ggtgctctta gattccccat   2040

acacccaagg gtaataaacg tgtacaagta cagtgttcat gatacgtgcc ttggtgggag   2100

tccgtggtgc cacagggaag gggctcccac tgcttctggt ctccagggac agtgctgctg   2160

gaaaggctag tgatgagctt caccctggag ctcctcccgg gaccttgcaa gcctctccat   2220

ccagcatctt ctctatctta gttgaatgcc ttctttctga acatttgttt taagaattat   2280

tttataaagt caacaatact ttgcttgaat tctttcttaa tttacgattt tttattataa   2340

aaatgtatag tgatacaatg ggacatgtga agaatacaga aaagtaacca ctttaatgca   2400

ataactgtta tcataatatt gtatttcgtg gtagtccttt cctgtagata tttttaatgc   2460

catttaatgc cattgtcacc ttggatttat gagtgaaaag tgtttctaaa aatatagaaa   2520

taatgtcaga tcagagtctg atcttctatg tttgtattta aatggattaa aagatccccg   2580

gtggttccat gaagaatttg taaagatcac tttctctttc ctccaagccc tgaaactttg   2640

ttcttcaaaa gagcgtttct tttttttttt ttttttagcc agtttataaa gtggaagtat   2700

taggagattc ataaatcttc tatattgaga attggctatg ttaataaata ttacaacatc   2760

attaaggttt tagctaagtt tgattcatgc tgtctgttaa atcaaaactg atctaaatca   2820

gaattattaa atgtgaggag cttttttaat acaggaaaag aaacatgtca tccacttgag   2880

ttaatagttt tcctacgttg atgacagccc tcatgagtag catccacatt tttaaaattt   2940

caaattggtt tttctactag tagattgtgt ttctagagaa agatacaagg cataggtgat   3000

tgtttaggat tttcctctag cctttgccat tacctttttg gggatgaggt tcacagtaga   3060

ctttgagtga ccgtcccacc gtgaagtgaa ttctctgagc tggtggtgtg gtgctggaag   3120

gaaggttatt tttggagcca ctctctcccc ttaaggatat ttcccaaggg cctgcttcaa   3180

ttctttgatg actttagagg tgaaaaaata tttttatgga gatgatgcag aaaactccaa   3240

ttcaggagcc cttgcgagta tatctgaagc acttatttgc taaggaaacc tgaattgata   3300

gcagtactgt gctgtctgga ataatgtcct tgatactgag ttgggaccag actggctttt   3360

atagtgacag gcaaagagga atttattgag atcactgctc atggcatttg ttgctgtaag   3420

aagtgttgcc tttgattgtt actaaccacg gatgggtaac ggtcatacat taggctagtg   3480

tttggtagga caaaatcttt ttagagcttt gagaattgtc atcctgttgg tcaactttga   3540

aatacaaatg tttgccctgg taattagcaa tgaactgctg gcagtttctt cagctgtgta   3600

tatacggatc tggcttttaa ttgatgaatc aacttctaca gaaacttttg cagggacagt   3660

gttgatgagg cagtttagct tgccagggtg atgataaagc ccaggtccct gcatgtatag   3720

tgctcttcta aagaatatgc attcttgaac tacttaactt tttaaaaatc acaataaatt   3780

tttgcactca aaatttgctt cgtatcagga gaaatgaact cattgttttg ttttgttttt   3840

tttttttttt aagatggagt cttgctatgt cacccaggct ggagggcagt ggtgcgatct   3900

cggctcactg ctacttccac ctcctgggct caagtgatcc tcccacctca gcctccaagt   3960

agctgggact acaggagtgc ttcaccacgc tgggctactt ttttatattt tttgtagaga   4020

tggggttttg ccatgttgtc caggctggtc ttgaactcct gggctcaagg gattctcctg   4080

cctcagtctc ccaaagtgct gggattacaa ggatgagcct ctgcacctgg ccctgaactc   4140

attattaaaa gccctttaaa tgtgaggctg ggtgccgtgc cttacatgtg taattccaat   4200

actttggaag gccaaggttg gaggattgct tgatcccaag agttcaagac cagcctgggc   4260

aacataggga gaccctgact ctacaaaaaa taaagtaaaa attaactggg tgtagtgtca   4320

catgcctgta gttccagcta cttaggaggc tgaggtggta ggattgcttg agcccagcag   4380

tttgaggttg cagtgaggtg tgattgcacc actgcactcc agcctgggtg acagaggaag   4440

accctgtccc aaaaccaaaa aaaagaaaag aaatacagag actgggtcat ttacaaagga   4500

aagaggttta attgactcgg ttcggctttc tgaggaagcc ttaggaaatt gacaatcatg   4560

gcagaagggg aagcagatgt cttacatggc agtgagtgag agcaagcaaa ggggaagagc   4620

ccccttataa aaccatcaga tctcgtgaga actggctgtc acaagaacag catgggggaa   4680

ctgtctccat gttccaatct ccttccacca ggtccctccc tcaacacgtg gggattatgg   4740

ggattacaat ttgaaatgag atttgggtgg ggaacagagc caaatcatat cattccaccc   4800

tggcccctcc caaatcacat gtccttttta catttcaaaa ccaatcatgc cttcacaaca   4860

gtcctccaga gtcttaactc attccagcat taacccaaaa gtccaagttc aaagtctcat   4920

ccaagacaag gcaagtccct tctgcctgtg agcctgtaac attaaaagca agttagtgac   4980

ttccaagata caatgggagt acagacattg gtaaatgttc ccattccaaa tgggagaaat   5040

tggccaaaac acaggggcta caggccccat gcaccactgc actccactgt gcaagtctga   5100

aacccggcag ggcactcctt aaattttttt tttttttttt tgagatggag tctcgctctg   5160

ttgcccaagc tggagtacag tggcacgatc tcggctcact gcaacctccg cctcttgggt   5220

tcaaaggatc atcctgcctc agcctccgga gtagctgggc tactcaggcg tgtgccacca   5280

tgcccggcta atttttgtat ttttagtaga gatggggcct gaccatgttg gtcaggctgg   5340

tctctaattc ctgacctcgt gatccacccg cctcagcctc tgaaagtgtt gggattacag   5400

gcgtgagcca ccatccccgg cctactcaat aaatcttaaa gttccggaat aatctccttt   5460

gactccatgt ctcacctcca ggtcacgctg atgcaagagg tgggctaatc tttctagtaa   5520

attccatatt taattcaaga aaccataact taaggcatgt aaaagagatc ctttgctcaa   5580

tgtgatgcca ttgtgcttat ccaaagtata ttattattac ccacaaaggg tgagagatta   5640

ggctgcagcc ataccccaag tggagtgagc agcaagacct gccccctgct cagagtgtag   5700

atgactgggg gcacctgcat tcctaggggc tctgccgtat gagctcctgt cgatgcggca   5760

aaggaccacc ttgcccaacg acagcgggaa ggcagaattt aaagctggca gctgtaagcg   5820

aacgtctatg tgtgcgcacg ggggcacgtg aaggcacagg tgcatcagcc aagaacctcc   5880

aattcacctc ttaaccttct cacctcacct gaaacccctt ctgccagaat cctgaaggtg   5940

gcccaggaac agggctccta acgttaggtg gaaatgggaa attcattgag atgtcacaag   6000

ctggaataag aaaattctga gctcacccgg aaactaatgc cctaaattaa gattattcag   6060

cttctcaatt tttaatagca aaatggagac ctgagtgtgg ataactttta gtatctgtgg   6120

gggatcctgg aaccaattcc ctgccaatat agaaggacaa ctgtctacag tacttgaagt   6180

attattaact acattcgcca tgctgtatgt tagatcccca gaacatattt atcctgcata   6240

tctaaaattt tgatcatttt acaaactttc tatttttttt gtcaattttc tccagctaga   6300

cacttgtgca atacggctat tatctgatct ttgccttaaa tgttgtgctt cttttccata   6360

tgcacgtatt ttgcaaaata taaagtgtgt agagctatat agcactcagc caagtggtgg   6420

gtacctgcag gtgcttcaga gaagtaaatt gatgctgcta atatttgttg aatggcacga   6480

atatgatgag caatagcagg tggtgccctt cagccagacc atcgctccgt gcgtctgatg   6540

catcttgcca aagagtagtt ctgggaggtg gttgcctcta gagaacacat tcctcctatt   6600

ctggggtccc gtgagagaaa gaaatgcttt tgcttttgat gtgggactct tactaagcct   6660

ttcttcagag aaaaggaagt gaaaaatgca ccccatgata atcagtttct tacaacatac   6720

tgtgatagta ccggcttcgt tgtttttagc tggaatcatt agcttccatt tttagaataa   6780

cagctattgg ctaaattagg ctacagtagg ccattaagat ggatgttgga attaaaaaca   6840

tttttggaaa aaagcctgct ttgagccttt gttataagcc cttgggtaga gatctgggtc   6900

ctgtttctga tttcttgtga gccttcactc tgacagtttt gtttccagaa acacactctt   6960

agcctgctcc tgaaatggga acagacaggc caacttcccc tctccagtct cccctgcggg   7020

tcaaagcttt actttcctgt catgttaaga aagaatagat ttaaccttga taatccatgt   7080

agtattctgt atttttacct tttccttatc tgaaaaaaag tgtatatatg gcatggaatt   7140

gattgcacag gcacatggca tgttggcttg tgaaccaatt gttaaaattt caagttaatc   7200

attaaaataa tatctttcaa attaagttat attaaaaaca aaggtaacat tctaaattca   7260

aaaaaaaaaa aaaaaaa                                                  7277


<210>  2
<211>  19
<212>  DNA
<213>  Artificial

<220>
<223>  antisense

<400>  2
gcagcctgag aaatgtttt                                                  19


<210>  3
<211>  21
<212>  DNA
<213>  Artificial

<220>
<223>  antisense

<400>  3
tagcagcctg agaaatgttt t                                               21


<210>  4
<211>  20
<212>  DNA
<213>  Artificial

<220>
<223>  antisense

<400>  4
agcagcctga gaaatgtttt                                                 20


<210>  5
<211>  23
<212>  DNA
<213>  Artificial

<220>
<223>  antisense

<400>  5
tagcagcctg agaaatgttt tct                                             23


<210>  6
<211>  20
<212>  DNA
<213>  Artificial

<220>
<223>  antisense

<400>  6
gcagcctgag aaatgttttc                                                 20


<210>  7
<211>  21
<212>  DNA
<213>  Artificial

<220>
<223>  antisense

<400>  7
agcagcctga gaaatgtttt c                                               21


<210>  8
<211>  22
<212>  DNA
<213>  Artificial

<220>
<223>  antisense

<400>  8
agcagcctga gaaatgtttt ct                                              22


<210>  9
<211>  22
<212>  DNA
<213>  Artificial

<220>
<223>  antisense

<400>  9
tagcagcctg agaaatgttt tc                                              22


<210>  10
<211>  21
<212>  DNA
<213>  Artificial

<220>
<223>  antisense

<400>  10
gcagcctgag aaatgttttc t                                               21


<210>  11
<211>  21
<212>  DNA
<213>  Artificial

<220>
<223>  antisense

<400>  11
gaaatgtttt ctactcaata a                                               21


<210>  12
<211>  19
<212>  DNA
<213>  Artificial

<220>
<223>  antisense

<400>  12
aaaacatttc tcaggctgc                                                  19


<210>  13
<211>  20
<212>  DNA
<213>  Artificial

<220>
<223>  sense primer

<400>  13
tggaccgaga cctcatgaca                                                 20


<210>  14
<211>  22
<212>  DNA
<213>  Artificial

<220>
<223>  sense primer

<400>  14
taaacatggg aggccctgaa ac                                              22


<210>  15
<211>  27
<212>  DNA
<213>  Artificial

<220>
<223>  sense primer

<400>  15
ttcctattca gaataagctg gcaccat                                         27


<210>  16
<211>  21
<212>  DNA
<213>  Artificial

<220>
<223>  sense primer

<400>  16
aggatgtgtc cgtctggtgt a                                               21


<210>  17
<211>  25
<212>  DNA
<213>  Artificial

<220>
<223>  sense primer

<400>  17
tgctgtctcc atgtttgatg tatct                                           25


<210>  18
<211>  21
<212>  DNA
<213>  Artificial

<220>
<223>  sense primer

<400>  18
tgacactggc aaaacaatgc a                                               21


<210>  19
<211>  22
<212>  DNA
<213>  Artificial

<220>
<223>  sense primer

<400>  19
agtccatatc ttgatggggg at                                              22


<210>  20
<211>  25
<212>  DNA
<213>  Artificial

<220>
<223>  sense primer

<400>  20
gggttcggcg tttggcgatg aatgg                                           25


<210>  21
<211>  21
<212>  DNA
<213>  Artificial

<220>
<223>  sense primer

<400>  21
gcctccaatc ctgcggtact g                                               21


<210>  22
<211>  22
<212>  DNA
<213>  Artificial

<220>
<223>  sense primer

<400>  22
tgaaacttac tggtgcctga ga                                              22


<210>  23
<211>  22
<212>  DNA
<213>  Artificial

<220>
<223>  sense primer

<400>  23
tctctgctcc ccacctctaa gt                                              22


<210>  24
<211>  21
<212>  DNA
<213>  Artificial

<220>
<223>  sense primer

<400>  24
ggtccttttc accagcaagc t                                               21


<210>  25
<211>  15
<212>  DNA
<213>  Artificial

<220>
<223>  antisense

<400>  25
ctaaatcatt taaca                                                      15


<210>  26
<211>  15
<212>  DNA
<213>  Artificial

<220>
<223>  antisense

<400>  26
taacatacag gtaag                                                      15


<210>  27
<211>  15
<212>  DNA
<213>  Artificial

<220>
<223>  antisense

<400>  27
gtaagtggat tttat                                                      15


<210>  28
<211>  15
<212>  DNA
<213>  Artificial

<220>
<223>  antisense

<400>  28
tttattccag cttag                                                      15


<210>  29
<211>  15
<212>  DNA
<213>  Artificial

<220>
<223>  antisense

<400>  29
cttagcagcc tgaga                                                      15


<210>  30
<211>  15
<212>  DNA
<213>  Artificial

<220>
<223>  antisense

<400>  30
tgagaaatgt tttct                                                      15


<210>  31
<211>  15
<212>  DNA
<213>  Artificial

<220>
<223>  antisense

<400>  31
tttctactca ataaa                                                      15


<210>  32
<211>  15
<212>  DNA
<213>  Artificial

<220>
<223>  antisense

<400>  32
ataaaaaaga aaaaa                                                      15


<210>  33
<211>  15
<212>  DNA
<213>  Artificial

<220>
<223>  antisense

<400>  33
aaaaaagcaa aattt                                                      15


<210>  34
<211>  15
<212>  DNA
<213>  Artificial

<220>
<223>  antisense

<400>  34
aattttagag agcct                                                      15


<210>  35
<211>  15
<212>  DNA
<213>  Artificial

<220>
<223>  antisense

<400>  35
agcctaacaa gatta                                                      15


<210>  36
<211>  15
<212>  DNA
<213>  Artificial

<220>
<223>  antisense

<400>  36
gattaagcct ttaaa                                                      15


<210>  37
<211>  15
<212>  DNA
<213>  Artificial

<220>
<223>  antisense

<400>  37
ttaaaacaga agctt                                                      15


<210>  38
<211>  15
<212>  DNA
<213>  Artificial

<220>
<223>  antisense

<400>  38
tttattccag cttag                                                      15


<210>  39
<211>  15
<212>  DNA
<213>  Artificial

<220>
<223>  antisense

<400>  39
ttattccagc ttagc                                                      15


<210>  40
<211>  15
<212>  DNA
<213>  Artificial

<220>
<223>  antisense

<400>  40
tattccagct tagca                                                      15


<210>  41
<211>  15
<212>  DNA
<213>  Artificial

<220>
<223>  antisense

<400>  41
attccagctt agcag                                                      15


<210>  42
<211>  15
<212>  DNA
<213>  Artificial

<220>
<223>  antisense

<400>  42
ttccagctta gcagc                                                      15


<210>  43
<211>  15
<212>  DNA
<213>  Artificial

<220>
<223>  antisense

<400>  43
tccagcttag cagcc                                                      15


<210>  44
<211>  15
<212>  DNA
<213>  Artificial

<220>
<223>  antisense

<400>  44
ccagcttagc agcct                                                      15


<210>  45
<211>  15
<212>  DNA
<213>  Artificial

<220>
<223>  antisense

<400>  45
cagcttagca gcctg                                                      15


<210>  46
<211>  15
<212>  DNA
<213>  Artificial

<220>
<223>  antisense

<400>  46
agcttagcag cctga                                                      15


<210>  47
<211>  15
<212>  DNA
<213>  Artificial

<220>
<223>  antisense

<400>  47
gcaccctgag aaatg                                                      15


<210>  48
<211>  15
<212>  DNA
<213>  Artificial

<220>
<223>  antisense

<400>  48
caccctgaga aatgt                                                      15


<210>  49
<211>  15
<212>  DNA
<213>  Artificial

<220>
<223>  antisense

<400>  49
accctgagaa atgtt                                                      15


<210>  50
<211>  15
<212>  DNA
<213>  Artificial

<220>
<223>  antisense

<400>  50
ccctgagaaa tgttt                                                      15


<210>  51
<211>  15
<212>  DNA
<213>  Artificial

<220>
<223>  antisense

<400>  51
cctgagaaat gtttt                                                      15


<210>  52
<211>  15
<212>  DNA
<213>  Artificial

<220>
<223>  antisense

<400>  52
ctgagaaatg ttttc                                                      15


<210>  53
<211>  15
<212>  DNA
<213>  Artificial

<220>
<223>  antisense

<400>  53
tgagaaatgt tttct                                                      15


<210>  54
<211>  15
<212>  DNA
<213>  Artificial

<220>
<223>  antisense

<400>  54
gagaaatgtt ttcta                                                      15


<210>  55
<211>  15
<212>  DNA
<213>  Artificial

<220>
<223>  antisense

<400>  55
agaaatgttt tctac                                                      15


<210>  56
<211>  21
<212>  DNA
<213>  Artificial

<220>
<223>  antisense

<400>  56
tagcagcctg agaaatgttt t                                               21


<210>  57
<211>  20
<212>  DNA
<213>  Artificial

<220>
<223>  antisense

<400>  57
agcagcctga gaaatgtttt                                                 20


