                         SEQUENCE LISTING

<110>  INSERM
 
<120>  METHODS AND COMPOSITIONS FOR CONTROLLING NEMATODES

<130>  BIO13136 EWBANK / MC

<160>  10    

<170>  PatentIn version 3.3

<210>  1
<211>  304
<212>  PRT
<213>  Caenorhabditis elegans

<400>  1

Met Ile Val Phe Val Ala Ala Ser Val Phe Cys Ser Leu Met Ser Lys 
1               5                   10                  15      


Ile Met Val Thr Arg Tyr Phe Phe Asp Tyr Pro Val Val Ile Leu Met 
            20                  25                  30          


Met Gln Ser Ala Ala Thr Leu Phe Val Ile Glu Val Thr Arg Val Leu 
        35                  40                  45              


Gly Ile Leu Lys Val Ala Pro Tyr Cys Phe Glu Lys Gly Arg His Ile 
    50                  55                  60                  


Val Ile Pro Ser Ile Leu Tyr Thr Ile Ser Gln Trp Ile Thr Val Ala 
65                  70                  75                  80  


Ser Phe Glu Gly Ile Ala Met Pro Asn Phe Asp Ser Val Lys Arg Leu 
                85                  90                  95      


Thr Pro Ile Leu Ile Leu Val Gly Leu Ala Ala Arg Asn Arg Gln Gln 
            100                 105                 110         


Arg Val Asp Gln Asn Lys Thr Phe Ile Ile Ile Gly Leu Ser Ile Ala 
        115                 120                 125             


Ser Ala Phe Ala Val Asn Leu Asp Leu Ser Val Asp Arg Tyr Ser Leu 
    130                 135                 140                 


Met Tyr Gly Leu Val Gly Ala Ile Leu Gln Ala Ala Ala Phe Val Leu 
145                 150                 155                 160 


Phe Glu Glu His Leu Gln Asn Tyr Asn Tyr Thr Glu Val Leu Tyr Met 
                165                 170                 175     


His Ser Phe Asn Ser Leu Val Phe Tyr Leu Leu Ala Asp Met Val Arg 
            180                 185                 190         


Asp Glu Leu Arg Asp Ala Phe Met Tyr Met Ile Thr Ser Ala His Pro 
        195                 200                 205             


Leu Phe Ile Ile Val Phe Ala Val Ser Met Phe Ala Gly Val Leu Phe 
    210                 215                 220                 


His Phe Thr Thr Phe Ser Cys Leu Glu Lys Asn Gly Pro Leu Asn Met 
225                 230                 235                 240 


Gln Ile Val Ser Asn Val Arg Ala Val Val Glu Thr Phe Leu Ala Tyr 
                245                 250                 255     


Tyr Leu Ser Val Tyr Leu Phe Tyr Asp Val Tyr Pro Gly Val Leu Asn 
            260                 265                 270         


Trp Ala Phe Leu Ala Val Thr Phe Val Ala Ala Arg Ala Leu Val Asn 
        275                 280                 285             


Arg Asp Cys Glu Pro Glu Ile Val Lys Gly Pro Trp Met Ser Lys Ala 
    290                 295                 300                 


<210>  2
<211>  329
<212>  PRT
<213>  Caenorhabditis elegans

<400>  2

Met Ile Val Ser Arg Arg Ile Pro Val Leu Ala Tyr Leu Phe Leu Ser 
1               5                   10                  15      


Cys Leu Ile Ala Leu Tyr Ala Phe Lys Phe His Leu Ser Thr Leu Val 
            20                  25                  30          


Asp Gly Ile Ile Phe Asn Asn Glu Asp Asp Pro Thr Pro Phe Asp Phe 
        35                  40                  45              


Ala Leu Ser Phe Gln Leu Lys Pro Glu Leu Pro Asp Glu Leu Pro Ala 
    50                  55                  60                  


Pro Asn Val Leu Val Leu Val Thr Thr Ile Ala Ser Glu Phe Glu Met 
65                  70                  75                  80  


Arg Asn Gln Val Arg Lys Ser Trp Ala Asn Tyr Thr Ser Asn Ala Val 
                85                  90                  95      


Arg Val Lys Phe Leu Met Gly Ile Pro Ala Asp Lys Gln Leu Pro Leu 
            100                 105                 110         


Ile Gln Lys Glu Ser Gln Glu Phe Asn Asp Leu Ile Ile Ala Asp Leu 
        115                 120                 125             


Asp Glu Gly Tyr Tyr Ser Leu Ala Ser Lys Thr Met Ala Met Leu Ile 
    130                 135                 140                 


Tyr Lys Thr Arg Tyr Tyr Pro Asp Thr Lys Cys Leu Val Lys Ala Asp 
145                 150                 155                 160 


Val Asp Asn Val Leu Ile Leu Arg Asn Tyr Glu Arg Leu Cys Glu Glu 
                165                 170                 175     


Ala Val Ala Pro Leu Ile Leu Gly Lys Cys Asp Val Ser Arg Thr Val 
            180                 185                 190         


Leu Arg Asn Thr Thr Lys Trp Ala Val Pro Glu Phe Val Tyr Ser Glu 
        195                 200                 205             


Pro Val Tyr Pro Thr Tyr Cys Ser Thr Gly Thr Tyr Val Leu Ala Gly 
    210                 215                 220                 


Lys Thr Val Pro Gln Ser Leu Ile Lys Glu Ala Met Ser Ser Pro Phe 
225                 230                 235                 240 


Ala Asn Ser Leu Asn Phe Arg Lys Leu Ser Glu Asp Val Ile Phe Thr 
                245                 250                 255     


Gly Ile Leu Ala Glu Lys Ala Gly Ile Lys Arg Arg His Ile Asn Gly 
            260                 265                 270         


Leu Ser Phe Phe Glu Ile Pro Glu Phe Phe Cys Arg Asn Gly Phe Lys 
        275                 280                 285             


Thr Thr Tyr Ser Thr His Leu Leu Ser Asp Lys Asn Pro Val Lys Asn 
    290                 295                 300                 


Phe Tyr Lys Leu Met Lys Ile Glu Gly Val Leu Cys Arg Trp Trp Asp 
305                 310                 315                 320 


Pro Tyr Ala Val Arg Arg Trp Arg Ser 
                325                 


<210>  3
<211>  802
<212>  PRT
<213>  Caenorhabditis elegans

<400>  3

Met Ala Thr Ser Ala Glu Met Ser Gly Thr Val Gln Gln Ile Glu Ser 
1               5                   10                  15      


Ile Ile Gln Thr Ile Glu Ser Lys Ile Asp Val Ser Ser Gln Gln His 
            20                  25                  30          


Ser Pro Ala Ser Asn Ser Ser Ser Thr Lys Ser Glu Asp Ser Gly Leu 
        35                  40                  45              


Asp Asp Gly Pro Lys Lys Ser Val Thr Ser Ala Lys Pro Ile Ser Arg 
    50                  55                  60                  


Lys Ser Ser Arg Met Ser Gln Ser Ser Gly Val Ser Leu Pro Pro Val 
65                  70                  75                  80  


Leu Glu Gln Leu Glu His Met Ile Ile Ser Asp Asp Trp Leu Gly Ser 
                85                  90                  95      


Glu Ser Thr Ser Pro Ser Gly Leu Lys Gln His Ala Gln Val Ala Lys 
            100                 105                 110         


Thr Arg Ser Arg Glu Gly Gln Lys Leu Ser Glu Leu Gly Arg Thr Leu 
        115                 120                 125             


Val Thr Ser Ala Ser Leu Lys Ser Tyr Ile Asp Leu Leu Ser Ser His 
    130                 135                 140                 


His Arg Gln Ser Ile Ala Ser Trp Leu Tyr Gly Asn Val Asn His Val 
145                 150                 155                 160 


Phe Ser Asn Leu Phe Arg Phe Ala Asp Ser Gln Ile Tyr Cys Ser Asp 
                165                 170                 175     


Pro Glu Ala Thr Ile Ser Leu Ser Ile Arg Asn Gly Ile Gly His Ala 
            180                 185                 190         


Val Lys Leu Ala Leu Lys Ser Ser Tyr Gly Thr Asp His Ser Thr Lys 
        195                 200                 205             


Gly Trp Arg Ala Phe Ala Glu Gln Gly Ala Pro Val Val Tyr Val Ser 
    210                 215                 220                 


Pro Ala Leu His Met Asp Leu Ser Ser Tyr Leu Ala Ser Glu Phe Gly 
225                 230                 235                 240 


Ile Ala Asp Val Thr Ile Leu Pro Lys Leu Asp Ser Asp Arg Gly Glu 
                245                 250                 255     


Ile Glu Gly Arg Ile Asp His His Gln Phe Glu Lys Ile Leu Asp Glu 
            260                 265                 270         


Asp Leu Ala Ala Gly Lys Lys Pro Leu Ile Leu Ile Gly Val Val Gly 
        275                 280                 285             


Thr Thr Ile Met Gly Gln Asn Asp Met Ile Ser Lys Ile Leu Glu Ile 
    290                 295                 300                 


Arg Glu Lys Lys Ala Lys Phe Trp Leu His Ile Thr Gly Gln Ala Ile 
305                 310                 315                 320 


Ala Ala Leu Thr Phe Arg Glu Pro Asn Asn Ile Leu Val His Val Leu 
                325                 330                 335     


Ser Gln Val Asp Ser Met Thr Val Pro Ile Ala Leu Trp Leu Gly Ile 
            340                 345                 350         


Pro Ser Ala Pro Val Val Thr Leu His Arg Pro Val Glu Gly Tyr Lys 
        355                 360                 365             


Ala Ser Tyr Arg Glu Lys Leu Asp Thr Leu Pro Trp Trp Val Ala Ser 
    370                 375                 380                 


Ser Tyr Leu Ser Gly Lys Lys Ile Val Asp Met Ile Glu Asn Ala Phe 
385                 390                 395                 400 


Leu Leu Ser Lys Val Met Leu Lys Gly Leu Ser Ala Ile Pro Glu Val 
                405                 410                 415     


Glu Met Ile Gly Val Asp Asn Pro Val Glu Leu Ala Asn Arg Val Tyr 
            420                 425                 430         


Lys Asn Lys Phe Thr Pro Pro Thr Val Leu Ile Phe Lys Tyr Asn Tyr 
        435                 440                 445             


Val Ser Ile Lys Asn Ala Ile Gln His His Lys Asp Leu Ile Gln Asn 
    450                 455                 460                 


Asn Asp Asp His Asp Ala Ile Ala Ile Ala Glu Lys Thr Leu Gln Asp 
465                 470                 475                 480 


Glu Leu Glu Tyr Gly Asp Tyr Leu Asn Ala Trp Leu Arg Asp Gly Leu 
                485                 490                 495     


Leu Pro Glu Ser Leu Pro Leu Gly Ile Asp Thr Ile Glu Leu Gly Gly 
            500                 505                 510         


Asn Tyr Gly Ile Ala Phe Arg Phe Cys Pro Leu Glu His Ala Ala Thr 
        515                 520                 525             


Tyr Ser Ser His Ile Asp His Val Gln Arg Phe Val Arg Lys Leu Thr 
    530                 535                 540                 


Asp Ile Met Arg Ile Val Glu Ser Thr Val Val Ser Lys Leu Lys Phe 
545                 550                 555                 560 


Ser Glu Leu Lys Asp Asp Phe Pro Ser Leu Val Leu Leu Pro Ile Arg 
                565                 570                 575     


Asn Trp Ala Gly Ile Gly Ala Val Cys Tyr Ile Pro Ser Ile Val Lys 
            580                 585                 590         


Glu Thr Asn Pro Glu Asp Trp Asn Asp Ile Gln Lys Gln Gln Ile Ser 
        595                 600                 605             


His Leu Asn Leu Glu Leu Val His Gln Leu Lys Ser Val Asp Ala Ala 
    610                 615                 620                 


Phe Ser Ser Gly Asp Cys Thr Arg Tyr Gly Val Ser Cys Val Lys Phe 
625                 630                 635                 640 


Gly Met Leu Ser Asp Val Lys Asp Leu His Asn Leu Val Glu Met Val 
                645                 650                 655     


Ala Gln Lys Gly Lys Glu Ile Glu Asn Ser Gln Gln Tyr Leu Asp Ser 
            660                 665                 670         


Leu Ala His Leu Ile Arg Gln Gly Ile Glu Ala Ala Asn Glu Ala Leu 
        675                 680                 685             


Arg Lys Glu Asn Asp Gln Arg Leu Gln Asn Glu Gly Met Met Arg Gln 
    690                 695                 700                 


Leu Pro Ile Met Gly Ser Leu Val Asn Trp Trp Ser Pro Leu Thr Pro 
705                 710                 715                 720 


Glu Ser Gln Asn Ile Arg Gly Arg Ala Phe Asn Leu Lys Thr Gly Glu 
                725                 730                 735     


Met Gln Glu Thr Asp Val Leu Phe Lys Ser Lys Lys Asn Met Asp Ala 
            740                 745                 750         


Thr Pro Pro Ile Thr Lys Asn Glu Thr Pro Gln Ile Pro His Glu Pro 
        755                 760                 765             


Phe Ala Thr Lys Ile Asp Glu Glu Pro Thr Ser Glu Ser Glu Thr Ala 
    770                 775                 780                 


Val Thr Glu Glu Ala Val Ser Ser Ala Glu Glu Ala Lys Pro Val Glu 
785                 790                 795                 800 


Ser Ser 
        


<210>  4
<211>  257
<212>  PRT
<213>  Caenorhabditis elegans

<400>  4

Met Arg Val Tyr Ser Leu Ile Leu Leu Cys Phe Ile Thr Phe Val His 
1               5                   10                  15      


Gly Gln Glu Lys Ala Glu Val Asp Ile Arg Val Ser Gly Ala Cys Ser 
            20                  25                  30          


Pro Ile Tyr Leu Ser Arg Lys Gly Ile Asp Ile Asn Lys Tyr Arg Pro 
        35                  40                  45              


Ser Ile Arg Phe Asn Pro Asp Lys Ile Gln Leu Ile Pro Lys Asn Pro 
    50                  55                  60                  


Val Ile Pro Gly Cys Ile Lys Ile Lys Ala Glu Gly Val Glu Ile Thr 
65                  70                  75                  80  


Arg Pro Thr Lys Asn Leu Ile Ala Glu Val Glu Met Arg Ile Gly Gly 
                85                  90                  95      


Thr Pro Asp Pro Asn Asn Pro Ser Leu Pro Cys Ser Lys Lys Ile Asp 
            100                 105                 110         


Glu Lys Val Asn Gln Cys Pro Cys Ala Lys Leu Glu Gly Ser Cys Val 
        115                 120                 125             


Phe Cys Asp Phe Cys Lys Gln Leu Lys Ala Gln Thr Ser Lys Ile Thr 
    130                 135                 140                 


Pro Ser Lys Leu Ser Arg Pro Glu His Lys Leu Ile Asp Glu Asp Cys 
145                 150                 155                 160 


Lys Cys Gly Asp Met Gln Pro Gly Leu Tyr Asp Ile Glu Thr Glu Met 
                165                 170                 175     


Cys Thr Pro Glu Met Asp Asp Phe Lys Asp Tyr Ile Pro Pro Glu Ile 
            180                 185                 190         


Gln Asn Asn Ile Leu Glu Lys Lys Pro Ile Ser Met Phe Ile Thr Val 
        195                 200                 205             


Tyr Leu Met Asp Met Glu Pro Arg Ser Ser Lys Glu Ser Tyr Leu Ser 
    210                 215                 220                 


Ala Phe Gly Lys Ala Ile Leu Gln Arg Arg Met Ala Gln Ser Thr Val 
225                 230                 235                 240 


Ala Cys Phe Leu Leu Gly Ile Asp Val Lys Leu Ala Leu Pro Ser Phe 
                245                 250                 255     


Asp 
    


<210>  5
<211>  746
<212>  PRT
<213>  Caenorhabditis elegans

<400>  5

Met Ser Ser Asn Lys Lys Lys Thr Val Arg Ser Pro Tyr Pro Phe Pro 
1               5                   10                  15      


Thr Lys Phe Pro Ser Pro Ile Glu Gln Ala Ser Tyr Lys Thr Tyr Asn 
            20                  25                  30          


Trp Ile Glu Asn Thr Leu Trp Pro Ile Lys Pro Ile Pro Phe Val Ala 
        35                  40                  45              


Thr Thr Val Ala Leu Ala Ala Thr Leu His Tyr Lys Tyr Pro Glu Asn 
    50                  55                  60                  


Ala Ile Leu Asp Leu Leu Pro Lys Phe Gly Ser Glu Val Ala Glu Ile 
65                  70                  75                  80  


Ala Lys Thr Thr Ala Val Ala Ala Ile Gly Ser Tyr Ala Gly Val Phe 
                85                  90                  95      


Thr Leu Arg Lys Leu Leu Lys His Phe Tyr Phe Ser Tyr Lys Gly Phe 
            100                 105                 110         


Leu Phe Asp Asn Pro Lys Lys Pro Cys Leu Lys Thr Lys Ile Trp Gly 
        115                 120                 125             


Ile Val Arg His Ile Leu Ser Ile Ser Pro Pro Ile Leu Glu Ser Cys 
    130                 135                 140                 


Asp Arg Leu Leu Pro Ser Leu Pro Val Pro Ala Leu Lys Asp Thr Ile 
145                 150                 155                 160 


Ser Glu Tyr Leu Asp Ser Met Lys His Ile Leu Ser Glu Gln Glu Tyr 
                165                 170                 175     


Glu Ile Val Ala Lys Gln Ala His Glu Phe Leu Glu Asn Glu Gly Lys 
            180                 185                 190         


Lys Leu Gln Arg Tyr Thr Trp Ile Tyr Ser Leu Phe Thr Asp Asn Tyr 
        195                 200                 205             


Val Thr Ser Phe Trp Gln Lys Tyr Ala Tyr Leu His Gly Arg Tyr Pro 
    210                 215                 220                 


Leu Met Ile Asn Ser Ser Val Ala His Cys Asp Leu Leu Arg Asp Lys 
225                 230                 235                 240 


Glu Ala Thr Arg Ala His Arg Ala Ala Arg Val Thr Trp Ile Glu Val 
                245                 250                 255     


Met Ser His Leu Ala Ile Asp Arg Gln Gln Tyr Lys Ala Leu Gly Asp 
            260                 265                 270         


Gly Leu Val Cys Thr Arg His Tyr Lys Asn Met Tyr Ala Val Thr Arg 
        275                 280                 285             


Glu Pro Gly Lys Lys Ile Asp Gln Leu Ile Leu His Gly Ile Gln Lys 
    290                 295                 300                 


His Ile Val Val Val Leu Arg Gly Lys Tyr Tyr Lys Ile His Val Val 
305                 310                 315                 320 


Asp Asp Lys Asn Asn Ile Tyr Thr Val Glu Gln Leu Thr Lys Ile Phe 
                325                 330                 335     


His Glu Met Ile Ser Arg Asp Glu Lys Glu Glu Gly Val Ile Gly Lys 
            340                 345                 350         


Ile Ala Ala Leu Thr His Asp Thr Arg Asp Ser Trp His Arg Asn Arg 
        355                 360                 365             


Gln Lys Tyr Phe Leu Gly Asn Val Lys Asn Ala Gln Ile Leu Lys Glu 
    370                 375                 380                 


Ile Glu Cys Ala Val Phe Phe Phe Thr Leu Asp Glu Asn Asp Asp Tyr 
385                 390                 395                 400 


Gly Tyr Asp Glu Lys Lys Pro Glu Val Leu Ser Asn Phe Leu Ala Asn 
                405                 410                 415     


Cys Leu Ser Gly Asp Gly Thr Asn Arg Trp Val Asp Lys Ser Leu Asn 
            420                 425                 430         


Tyr Ile Cys Ser Lys Asn Ala Arg Cys Gly Gly Thr Thr Glu His Ser 
        435                 440                 445             


Ile Ala Asp Gly Ala Glu Phe Asp His Ile Met Glu Asn Phe Val Tyr 
    450                 455                 460                 


Val Asp Leu Glu Val Leu Lys Tyr Lys Ser Ile Glu Glu Gln Glu Lys 
465                 470                 475                 480 


Met Ala Val Ile Glu Glu Asn Asp Lys Lys Ser Leu Lys Leu Ala Thr 
                485                 490                 495     


Pro Leu Asn Phe Glu Val Pro Asp Gln Glu Met Leu Ser Glu Ile Thr 
            500                 505                 510         


Arg Cys Tyr Asp Ala His Gln Ile Ala Lys Asn Asp Leu Asp Leu Tyr 
        515                 520                 525             


Ala Leu Ala Phe Arg Asp Phe Gly Lys Gly Arg Ile Lys Lys Cys Gly 
    530                 535                 540                 


Val Ser Pro Asp Ala Phe Ile Gln Met Ala Ile Gln Leu Ala Asn Tyr 
545                 550                 555                 560 


Arg Asp Gln Gly Lys Phe Val Leu Thr Tyr Glu Pro Ala Ser Ala Arg 
                565                 570                 575     


Phe Phe Ala Asn Ser Arg Thr Glu Thr Leu Arg Thr Val Asn Asp His 
            580                 585                 590         


Ser Cys Glu Phe Val Glu Ala Met Leu Asn Ala Asn Glu Thr Lys Glu 
        595                 600                 605             


Ala Lys Ile Ala Leu Leu Lys Lys Ala Cys Glu Thr His Val Leu Arg 
    610                 615                 620                 


Asn Lys Lys Cys Met Val Gly Gln Gly Val Asp Arg His Leu Phe Val 
625                 630                 635                 640 


Leu Tyr Ile Leu Ser Gln Gly Thr Gly Ile Gln Ser Pro Phe Leu Asp 
                645                 650                 655     


Asn Tyr Ile Asn Gln Lys Trp Lys Leu Ser Thr Ser His Val Pro Asn 
            660                 665                 670         


Val Thr Asn Gln Cys Asp Glu Asp Thr Asp Ser Asp Asn Thr Trp Leu 
        675                 680                 685             


Gly Ala Cys Phe Gly Ala Val Ala Ala Asp Gly Tyr Gly Ile Cys Tyr 
    690                 695                 700                 


Arg Phe Gly Gly Asn His Gly Ile Phe Ala Asn Ile Thr Ser Tyr His 
705                 710                 715                 720 


Ser Ala Ala Asn Thr Asp Ser Thr Lys Phe Ala Lys Leu Leu Ser Glu 
                725                 730                 735     


Ser Phe His Glu Leu Ser Asn Leu Phe Val 
            740                 745     


<210>  6
<211>  440
<212>  PRT
<213>  Caenorhabditis elegans

<400>  6

Met Glu Gly His Ser Asn Thr Ser Val Ile Leu His Thr Tyr Gln Gln 
1               5                   10                  15      


Gln Gln Pro Gln Gln Leu Ile Ser Ser Ile Ile Pro Gln Thr Leu Ser 
            20                  25                  30          


Asp Gly Tyr Gly Ile Ser Ala Pro Ile Ser Gln Ala Asp Cys Ser Gly 
        35                  40                  45              


Asn Ser Asn Phe Val Asn Thr Asn Pro Trp Asn Asn Thr Thr Phe Gln 
    50                  55                  60                  


Ala Tyr Gln Thr Asp Ala Gln Phe Thr Asn Glu Ile Ser Val Leu Asn 
65                  70                  75                  80  


Tyr Pro Asn Val Tyr Asp Asp Phe Ser Lys Glu Ser Ser Asn Gly Ile 
                85                  90                  95      


Leu Ser Asp Pro Ser Leu His Gly Ser Asn Ser Ser Ser Ser Thr Ser 
            100                 105                 110         


Asp Val Gly Ser Ser Val Asp Cys Ser Ile Ser Pro Glu Pro Ile Leu 
        115                 120                 125             


Met Pro Ser Val Lys Arg Gly Arg Pro Thr Glu Asn Pro Cys Trp Ala 
    130                 135                 140                 


Tyr Phe His Arg Ile Asp Asp Gln Leu Val Lys Cys Arg Leu Cys Thr 
145                 150                 155                 160 


Lys Val Val Arg Ser Ala Cys Ala Thr Asn Met Thr Lys His Leu Glu 
                165                 170                 175     


Arg His His Ala Asp Asp Tyr Gln Lys Val Thr Gly Gln Leu Lys Leu 
            180                 185                 190         


Phe Arg Met Asn Asp Val Gly Ile Arg Ser Lys Met His Tyr Glu Val 
        195                 200                 205             


Ala Asp Asn Pro Leu Ser Thr Leu Pro Val Val Thr Asn Ser Tyr Ile 
    210                 215                 220                 


Leu Pro Lys Met Glu Pro Met Asp Thr Phe Asp Pro Ser Gln Tyr Tyr 
225                 230                 235                 240 


Gly Met Gln Gln Asp Pro Thr Leu Asn Gln Gln Gln Phe Ile Gln Phe 
                245                 250                 255     


Glu Gln Pro Gln Ala Ser Ile Asp Pro Gln Thr Trp Pro Leu Thr His 
            260                 265                 270         


Phe Trp Gln Asn Thr Ala Gln Thr Asn Ile Met Ser His Leu Gly Glu 
        275                 280                 285             


Ala Ser Thr Ser Thr Leu Gly Ser Ser Val Ile Gln Glu Ala His Lys 
    290                 295                 300                 


Met Asn Pro Asp Ser Asn Asp Lys Ser Phe Gln Leu Asp Leu Glu Gln 
305                 310                 315                 320 


Gln Asn Cys Val Ile Ile Glu Gln Lys Leu Asp Asp Lys Pro Arg Val 
                325                 330                 335     


Thr Lys Pro Thr Thr Lys Pro Tyr Gln Lys Arg Asn Arg Lys Thr Glu 
            340                 345                 350         


His Pro Val Trp Ala Phe Phe Lys Arg Thr Gly Asp Gly Asn Ala Glu 
        355                 360                 365             


Cys Ile Ile Cys Gln Gly Val Val Lys Ser Pro Cys Ser Ser Asn Phe 
    370                 375                 380                 


Met Arg His Leu Met Arg His His Ser Thr Glu Tyr Asn Asp Val Tyr 
385                 390                 395                 400 


Leu Lys Trp Ile Glu Lys Arg Asn Ile Thr His Pro Gly Ile His Cys 
                405                 410                 415     


Thr Ser Val Pro Pro Pro Ala Phe Ile Asn Asn Glu Thr Ser Arg Thr 
            420                 425                 430         


Glu Gln Thr Thr Phe Ser Val Lys 
        435                 440 


<210>  7
<211>  357
<212>  PRT
<213>  Caenorhabditis elegans

<400>  7

Met Phe Ser Ser Arg His Ile Leu Ser Asn Val Arg Pro Ile Ile Lys 
1               5                   10                  15      


Asn Leu Asp Leu Thr Arg Gly Phe Ser Asp Arg Lys Thr Lys Tyr Phe 
            20                  25                  30          


Asp Leu Asn Asp Leu Ile Lys Thr Val Asn Val Thr Tyr Lys Thr Gly 
        35                  40                  45              


Val Asn Leu Glu Glu Thr Thr Thr Val Glu Ser Lys Tyr Val Asp Val 
    50                  55                  60                  


Thr Pro Ser Ser Asn Thr Lys Gly Thr Val Val Thr Leu Ser Gly Ser 
65                  70                  75                  80  


Pro Gly Thr His Asn Asp Phe Lys Tyr Met Lys Ser Phe Phe Glu Gln 
                85                  90                  95      


Lys Lys Ile Arg Leu Ile Cys Thr Asn Tyr Pro Gly Ser Glu Phe Val 
            100                 105                 110         


Thr Gly Gly Leu His Asn Ser Tyr Thr Asn Gln Asp Arg Asn Ser Tyr 
        115                 120                 125             


Met Lys Ser Leu Met Glu Thr Leu Glu Leu Lys Asn Val Asn Arg Leu 
    130                 135                 140                 


Ile Ile Met Gly His Ser Arg Gly Gly Glu Asn Ala Leu Gln Leu Thr 
145                 150                 155                 160 


Ser Met Leu Ser Asn Asp Glu Asn Trp Pro Leu Val Gly Ala Val Met 
                165                 170                 175     


Ile Asn Ser Pro Gly Phe Ala Pro His Lys Gly Ile Ser Lys Arg Met 
            180                 185                 190         


Gly Thr Ile Asn Phe Ile Ile Ser Leu Ile Lys Arg His Asn Lys Thr 
        195                 200                 205             


Ile Asn Ser Ile Leu His Pro Ile Leu His Tyr Phe Tyr Asn Asn Leu 
    210                 215                 220                 


Ile Gly Leu Arg Val Ser His Gly Lys Val Ala Ala Ala Ala Ile Leu 
225                 230                 235                 240 


Pro Met Gln Thr Phe Ala Phe Asp Glu Gln Lys Leu Ser Ile Asp Asp 
                245                 250                 255     


Leu Arg Ala Lys Pro Gly Ile Arg Ala Phe Tyr Gly Tyr Gly Ser Lys 
            260                 265                 270         


Asp Phe Leu Ile Asp Glu His Gln Ser Glu Glu Val Ala Met Tyr Phe 
        275                 280                 285             


Ser Glu Glu Asp His Tyr Val Ile Ser Asn Lys Gln Asp Ala Glu Lys 
    290                 295                 300                 


Ala Ile Lys Glu Ala Arg Lys Ser Phe Thr Thr Gly Lys Gln Phe Val 
305                 310                 315                 320 


Thr Ala Asn Phe Lys Glu Glu Gly His Phe Leu Gln Lys Thr Tyr Pro 
                325                 330                 335     


Glu Phe Ile Val Glu Val Val Asp Ser Ile Phe Asp Ala Asp Lys Glu 
            340                 345                 350         


Val Asp Thr Lys Ile 
        355         


<210>  8
<211>  2232
<212>  PRT
<213>  Caenorhabditis elegans

<400>  8

Met Lys Val Pro Arg Gly Ile Gly Leu Val Phe Ile Phe Ala Val Ala 
1               5                   10                  15      


Ala Ala Leu Val Ala Gly Leu Ile Leu Thr Ile Val Leu Val Ser Arg 
            20                  25                  30          


Pro Ser Pro Ala Glu Pro Phe Thr Gly Arg Val Ile Thr Val Gly Ile 
        35                  40                  45              


Cys Asn Ser Gly Ser Glu Pro Ser Lys Ala Ser Ser Phe Arg Phe Lys 
    50                  55                  60                  


Arg Asp Ala Thr Thr Ser Cys Ser Phe Asp Ala Asn Arg Asp Gln Leu 
65                  70                  75                  80  


Lys Asn Phe Leu Ser Ser Ser Ala Ala Asp Thr Ser Phe Ile Val Met 
                85                  90                  95      


Ser Tyr Ser Asp Lys Pro Ser Pro Ser Thr Val Leu Pro Arg Asp Gln 
            100                 105                 110         


Ala Ile Glu Leu Leu Asn Ser Met Lys Lys Asp Gly Ser Lys Thr Ile 
        115                 120                 125             


Gln Gln Ala Pro Ala Phe Ala Ser Tyr Asp Pro Lys Ala Tyr Glu Asn 
    130                 135                 140                 


Ser Asp Leu Val Phe Phe Thr Pro Cys Lys Thr Asp Tyr Thr Gly Tyr 
145                 150                 155                 160 


Asp Ala Asp Met Ala Ala Val Arg Thr Thr Ile Asn Asn Val Gln Thr 
                165                 170                 175     


Lys Lys Tyr Val Ile Val Ser Leu Ala Met Asp Gln Gly Asn Met Thr 
            180                 185                 190         


Gln Lys Tyr Gly Asp Leu Asn Thr His Asn Ile Gly Asn Asn Ala Thr 
        195                 200                 205             


Asp Ile Thr Asn Asp Ile Asn Asn Val Leu Asn Ile Thr Ala Ala Thr 
    210                 215                 220                 


Ser Pro Ser Thr Ala Val Thr Ser Pro Ser Ser Leu Gly Thr Ser Ser 
225                 230                 235                 240 


Ser Pro Leu Pro Ser Ser Ile Ser Thr Ser Ala Leu Pro Ile Ala Ser 
                245                 250                 255     


Ser Ser Ala Ser Ser Ser Pro Ser Ala Ala Ser Ser Thr Thr Pro Val 
            260                 265                 270         


Val Leu Ser Ser Ser Thr Ile Gln Ser Ser Ser Gly Thr Phe Pro Ser 
        275                 280                 285             


Ser Val Ala Ser Ser Pro Ser Thr Val Gly Ser Thr Ser Gly Ala Ala 
    290                 295                 300                 


Ser Ser Ser Ser Tyr Ala Thr Val Ser Thr Ile Ala Gly Ser Thr Gly 
305                 310                 315                 320 


Ser Thr Ile Thr Pro Val Pro Gly Ser Ser Ser Thr Ile Gly Ser Ser 
                325                 330                 335     


Thr Pro Ser Ala Ser Ser Ser Ser Ser Gly Thr Met Ser Thr Ile Ser 
            340                 345                 350         


Gly Ser Thr Gly Ser Thr Val Thr Val Val Pro Gly Ser Ser Ser Thr 
        355                 360                 365             


Phe Ala Ser Ser Thr Pro Ile Ala Ser Ser Ser Ser Pro Gly Ser Thr 
    370                 375                 380                 


Val Thr Val Ala Pro Gly Ser Ser Ser Thr Tyr Gly Ser Ser Thr Pro 
385                 390                 395                 400 


Ser Ala Ser Ser Ser Ser Ser Gly Thr Met Ser Thr Asn Ser Gly Ser 
                405                 410                 415     


Thr Gly Ser Thr Val Thr Val Ala Pro Val Ser Ser Ser Thr Phe Gly 
            420                 425                 430         


Ser Ser Thr Pro Ile Ala Ser Ser Ser Ser Ser Gly Ser Thr Val Thr 
        435                 440                 445             


Val Val Ser Gly Ser Ser Ser Thr Tyr Gly Ser Ser Thr Pro Ser Ala 
    450                 455                 460                 


Ser Ser Ser Ser Ala Gly Thr Ala Ser Thr Ile Ser Gly Ser Thr Gly 
465                 470                 475                 480 


Ser Thr Ala Thr Ile Val Pro Gly Ser Ser Ser Ser Val Gly Ser Ser 
                485                 490                 495     


Thr Gln Ser Ala Ser Pro Ser Ser Pro Gly Thr Met Ser Thr Val Ser 
            500                 505                 510         


Gly Pro Thr Gly Ser Thr Val Thr Val Val Pro Gly Ser Ser Thr Ser 
        515                 520                 525             


Pro Ala Pro Ser Ser Ser Pro Asn Pro Ser Ser Ser Pro Ala Ser Thr 
    530                 535                 540                 


Gly Ser Thr Ile Thr Ile Ser Gly Ser Ser Ser Ile Ile Val Ser Thr 
545                 550                 555                 560 


Val Ser Gly Ser Thr Val Ser Gly Ser Thr Gly Thr Ser Gln Ser Thr 
                565                 570                 575     


Leu Ala Ser Ser Thr Ala Thr Pro Gly Ser Ser Ser Thr Val Pro Ser 
            580                 585                 590         


Ser Ser Ser Pro Gln Pro Ser Ser Gln Ser Pro Ala Pro Asn Thr Gly 
        595                 600                 605             


Ser Thr Thr Pro Ser Gln Thr Ser Ser Gln Ser Pro Ser Pro Ser Met 
    610                 615                 620                 


Asn Pro Ser Ser Ser Thr Pro Thr Gly Ser Ser Gln Ser Thr Ile Thr 
625                 630                 635                 640 


Pro Glu Gly Ser Thr Ala Ser Ser Pro Thr Gly Ser Thr Gly Ser Thr 
                645                 650                 655     


Phe Ser Val Ala Thr Glu Val Thr Ser Gln Ser Thr Val Pro Ser Gly 
            660                 665                 670         


Ser Ser Leu Gly Thr Gln Ser Thr Asn Ser Ser Pro Ser Pro Ser Ser 
        675                 680                 685             


Leu Ser Pro Ser Thr Ser Gly Met Ser Thr Leu Thr Ser Glu Pro Ser 
    690                 695                 700                 


Pro Ser Ser Thr Gln Ser Ser Gly Ala Gln Ser Thr Leu Thr Thr Pro 
705                 710                 715                 720 


Ser Pro Asn Pro Ser Gln Ser Thr Ser Ser Leu Glu Ser Ser Thr Ser 
                725                 730                 735     


Gly Ala Thr Thr Ser Ser Gly Ser Ala Gly Thr Thr Met Thr Ser Pro 
            740                 745                 750         


Ser Gln Ser Ser Ser Val Gly Ser Ser Gln Gly Ser Thr Ser Pro Ala 
        755                 760                 765             


Ala Ser Thr Thr Ser Gly Glu Met Thr Ser Gln Gly Ser Thr Gln Thr 
    770                 775                 780                 


Pro Gly Ser Ser Val Ser Thr Ser Ala Ala Ile Leu Thr Ser Thr Gln 
785                 790                 795                 800 


Gln Ser Val Ser Thr Asn Ser Pro Gly Ser Thr Val Thr Arg Pro Ser 
                805                 810                 815     


Thr Val Ser Gly Ser Thr Ser Ser Gly Ser Thr Val Thr Val Gly Ser 
            820                 825                 830         


Thr Glu Ala Ser Thr Ser Gly Ser Ser Val Ala Ser Ser Ser Pro Ala 
        835                 840                 845             


Pro Ser Thr Ser Gln Asn Pro Asn Pro Ser Thr Ser Ser Gly Ser Ser 
    850                 855                 860                 


Met Ile Thr Gln Ser Pro Tyr Pro Ser Gln Ser Thr Ser Pro Val Glu 
865                 870                 875                 880 


Ser Ser Thr Thr Pro Ser Pro Gly Ser Pro Gly Thr Thr Leu Thr Ser 
                885                 890                 895     


Thr Ser Pro Ser Pro Ser Gln Ser Thr Thr Ile Gly Ser Thr Gln Gly 
            900                 905                 910         


Ser Thr Ser Pro Gly Ile Ser Thr Thr Ser Glu Glu Met Thr Ser Gln 
        915                 920                 925             


Gly Ser Thr Gln Thr Pro Gly Ser Thr Gly Ser Thr Val Thr Gln Pro 
    930                 935                 940                 


Ser Thr Val Ser Asp Ser Thr Ser Ser Gly Ser Thr Val Thr Val Gly 
945                 950                 955                 960 


Ser Thr Glu Gly Ser Ser Ser Pro Ile Pro Ser Thr Ser Gln Asn Thr 
                965                 970                 975     


Asn Pro Ser Thr Ser Ser Gly Ser Ser Met Ser Thr Gln Thr Pro Gln 
            980                 985                 990         


Ser Ser Gln Ser Thr Ser Pro Val  Glu Ser Ser Thr Ser  Gly Ala Thr 
        995                 1000                 1005             


Ser Ser  Ser Gly Ser Pro Gly  Thr Thr Leu Thr Ser  Ile Ser Pro 
    1010                 1015                 1020             


Ser Pro  Ser Pro Ser Ser Thr  Ile Gly Ser Ser Gln  Gly Ser Thr 
    1025                 1030                 1035             


Ser Pro  Val Val Ser Thr Ile  Ser Gln Gly Ser Thr  Glu Thr Pro 
    1040                 1045                 1050             


Gly Ser  Thr Gly Ser Thr Val  Thr Lys Pro Ser Thr  Val Ser Gly 
    1055                 1060                 1065             


Ser Ala  Ser Ser Gly Ser Thr  Ala Thr Met Gly Ser  Thr Glu Ala 
    1070                 1075                 1080             


Ser Ser  Thr Ser Gly Gly Ser  Ser Thr Ser Pro Asn  Pro Ser Gln 
    1085                 1090                 1095             


Ser Thr  Ser Pro Ser Thr Ser  Gly Ala Thr Ser Ser  Pro Gly Ser 
    1100                 1105                 1110             


Ser Gly  Thr Thr Leu Thr Ser  Ile Ser Pro Ser Pro  Ser Gln Ser 
    1115                 1120                 1125             


Ser Thr  Ile Gly Ser Ser Gln  Gly Ser Thr Ser Pro  Val Val Ser 
    1130                 1135                 1140             


Thr Thr  Ser Gly Asp Met Thr  Ser Gln Gly Ser Thr  Gln Ile Pro 
    1145                 1150                 1155             


Gly Ser  Thr Gly Ser Thr Val  Thr Gln Pro Ser Thr  Gly Ser Gly 
    1160                 1165                 1170             


Ser Thr  Ser Thr Ser Gly Glu  Ile Thr Ser Gln Gly  Ser Thr Gln 
    1175                 1180                 1185             


Thr Pro  Arg Ser Ser Leu Ser  Thr Ser Pro Ala Ile  Ser Thr Ser 
    1190                 1195                 1200             


Thr Gln  Gln Ser Val Ser Thr  Asn Ser Pro Gly Ser  Thr Val Thr 
    1205                 1210                 1215             


Gln Pro  Ser Thr Val Arg Gly  Ser Thr Ser Ser Gly  Ser Thr Val 
    1220                 1225                 1230             


Thr Thr  Gly Ser Thr Glu Gly  Ser Ser Thr Ser Gly  Ser Ser Ser 
    1235                 1240                 1245             


Ala Thr  Ser Leu Ser Ser Ser  Ser Pro Val Pro Ser  Thr Ser Gln 
    1250                 1255                 1260             


Ser Pro  Asn Pro Ser Thr Ser  Gly Ser Ser Thr Pro  Thr Pro Asn 
    1265                 1270                 1275             


Pro Ser  Gln Ser Thr Ser Pro  Val Val Ser Thr Thr  Thr Gly Glu 
    1280                 1285                 1290             


Met Thr  Ser His Gly Ser Thr  Gln Thr Pro Ser Thr  Ile Gly Ser 
    1295                 1300                 1305             


Thr Val  Thr Gln Pro Ser Thr  Val Ser Gly Ser Asn  Ser Ser Gly 
    1310                 1315                 1320             


Ser Thr  Val Thr Ile Gly Ser  Ser Glu Ala Ser Thr  Ser Gly Ser 
    1325                 1330                 1335             


Ser Phe  Lys Thr Ser Pro Ser  Ser Ile Ser Pro Val  Pro Thr Ser 
    1340                 1345                 1350             


Ser Pro  Ile Pro Ser Thr Thr  Phe Ala Ser Ser Thr  Ser Gly Ser 
    1355                 1360                 1365             


Thr Ile  Ser Asp Val Ser Ser  Val Ser Thr Thr Ser  Leu Ala Pro 
    1370                 1375                 1380             


Leu Ser  Ser Ser Leu Pro Ser  Thr Val Pro Ser Ser  Thr Gln Ser 
    1385                 1390                 1395             


Phe Ser  Ser Thr Ser Glu Gly  Ser Ser Lys Ala Ser  Ser Ser Pro 
    1400                 1405                 1410             


Val Pro  Ser Gln Thr Ser Ser  Thr Pro Thr Asn Pro  Thr Gly Ser 
    1415                 1420                 1425             


Thr Glu  Ser Ser Thr Leu Leu  Ser Ser Thr Ile Ser  Gly Ser Thr 
    1430                 1435                 1440             


Gln His  Thr Thr Met Ser Lys  Ala Ser Ser Gly Ser  Thr Ser Pro 
    1445                 1450                 1455             


Ser Thr  Asn Ser Gln Thr Gly  Ser Thr Val Thr Met  Gly Ser Ser 
    1460                 1465                 1470             


Ser Thr  Ser Gly Val Ser Thr  Ser Ser Ala Ser Ser  Thr Gln Pro 
    1475                 1480                 1485             


Gln Met  Ser Thr Ser Gln Gly  Ser Ser Ala Gly Ser  Thr Val Ala 
    1490                 1495                 1500             


Ser Ser  Thr Ala Ser Pro Ala  Ala Ser Ser Thr Ala  Pro Ser Ser 
    1505                 1510                 1515             


Thr Gly  Thr Met Ser Ser Thr  Ser Ser Gly Thr Val  Gly Ser Thr 
    1520                 1525                 1530             


Ile Ser  Glu Ser Ser Thr Thr  Ala Ser Ala Ser Ser  Gln Thr Gly 
    1535                 1540                 1545             


Ser Thr  Val Thr Met Gly Ser  Ser Ser Thr Ser Gly  Val Ser Thr 
    1550                 1555                 1560             


Ser Ser  Ala Ser Ser Thr Gln  Pro Gln Met Ser Thr  Ser Gln Gly 
    1565                 1570                 1575             


Ser Ser  Ala Gly Ser Thr Val  Ala Ser Ser Thr Ala  Gly Leu Val 
    1580                 1585                 1590             


Ser Thr  Ser Thr Val Pro Ser  Ser Thr Gly Thr Met  Gly Ser Thr 
    1595                 1600                 1605             


Ser Ser  Gly Thr Val Gly Ser  Thr Ile Ser Glu Ser  Ser Thr Thr 
    1610                 1615                 1620             


Ala Ser  Ala Ser Ser Gln Thr  Gly Ser Thr Val Thr  Met Gly Ser 
    1625                 1630                 1635             


Ser Ser  Thr Ser Gly Val Ser  Thr Ser Ser Ala Ser  Ser Thr Gln 
    1640                 1645                 1650             


Pro Gln  Met Ser Thr Ser Gln  Gly Ser Ser Ala Gly  Ser Thr Val 
    1655                 1660                 1665             


Ala Ser  Ser Thr Thr Gly Leu  Val Ser Thr Ser Thr  Val Pro Ser 
    1670                 1675                 1680             


Ser Thr  Gly Thr Met Gly Ser  Thr Ser Ser Gly Thr  Val Gly Ser 
    1685                 1690                 1695             


Thr Ile  Ser Glu Ser Ser Thr  Ala Ala Ser Ala Ser  Ser Gln Thr 
    1700                 1705                 1710             


Gly Ser  Thr Val Thr Met Gly  Ser Ser Ser Thr Ser  Gly Val Ser 
    1715                 1720                 1725             


Thr Ser  Ser Ala Ser Ser Gly  Gln Pro Gln Met Ser  Thr Ser Gln 
    1730                 1735                 1740             


Gly Ser  Ser Ala Gly Ser Thr  Val Val Ser Ser Thr  Ala Ser Pro 
    1745                 1750                 1755             


Ala Ala  Ser Ser Thr Ala Pro  Ser Ser Thr Gly Thr  Met Ser Ser 
    1760                 1765                 1770             


Thr Ser  Ser Gly Thr Val Gly  Ser Thr Met Ser Gln  Ser Ser Thr 
    1775                 1780                 1785             


Ala Ala  Ser Thr Thr Ser His  Thr Gly Ser Thr Val  Thr Leu Gly 
    1790                 1795                 1800             


Ser Ser  Ser Thr Ser Ser Asn  Gln Met Ser Thr Ser  Gln Gly Ser 
    1805                 1810                 1815             


Ser Val  Gly Ser Thr Val Ala  Ser Ser Thr Ala Gly  Leu Val Ser 
    1820                 1825                 1830             


Thr Ser  Thr Val Pro Ser Ser  Thr Gly Thr Met Gly  Ser Thr Ser 
    1835                 1840                 1845             


Ser Gly  Thr Val Gly Ser Thr  Ile Ser Glu Ser Ser  Thr Thr Ala 
    1850                 1855                 1860             


Ser Ala  Ser Ser Gln Thr Gly  Ser Thr Val Thr Met  Gly Ser Ser 
    1865                 1870                 1875             


Ser Thr  Ser Gly Val Ser Thr  Ser Ser Ala Ser Ser  Thr Gln Pro 
    1880                 1885                 1890             


Gln Met  Ser Thr Ser Gln Gly  Ser Ser Ala Gly Ser  Thr Val Ala 
    1895                 1900                 1905             


Ser Ser  Thr Ala Gly Leu Val  Ser Thr Ser Thr Val  Pro Ser Ser 
    1910                 1915                 1920             


Thr Gly  Thr Met Gly Ser Thr  Ser Ser Gly Thr Val  Gly Ser Thr 
    1925                 1930                 1935             


Ile Ser  Glu Ser Ser Thr Ala  Ala Ser Thr Ser Ser  Gln Thr Gly 
    1940                 1945                 1950             


Ser Thr  Val Thr Ile Gly Ser  Thr Ser Gly Thr Asn  Pro Ser Ser 
    1955                 1960                 1965             


Pro Arg  Ser Leu Ser Gln Ile  Thr Ile Thr Pro Ser  Pro Ser Gln 
    1970                 1975                 1980             


Ser Thr  Glu Ser Thr Gln Thr  Ser Leu Pro Ser Ser  Ser Pro Ser 
    1985                 1990                 1995             


Pro Ser  Thr His Ser Val Ser  Ser Ser Glu Gly Thr  Thr Met Ser 
    2000                 2005                 2010             


Ser Gly  Ala Thr Thr Ser Gly  Asp Lys Met Ser Phe  Leu Ser Ser 
    2015                 2020                 2025             


Thr Gly  Thr Thr Val Ser Phe  Ser Ser Arg Gly Ser  Ser Leu Ala 
    2030                 2035                 2040             


Thr Thr  Ser Ala Pro Lys Pro  Ser Val Thr Cys Leu  Phe Met Tyr 
    2045                 2050                 2055             


Asp Thr  Gln Ser Lys Glu Ile  Asp Gln Thr Ala Ile  Asn Thr Tyr 
    2060                 2065                 2070             


Lys Thr  Tyr Phe Asn Phe Ala  Leu Leu Val Ala Ser  Lys Leu Asn 
    2075                 2080                 2085             


Asn Glu  Ser Ile Leu Thr Gly  Tyr Ile Asp Asn Phe  Gly Tyr Ser 
    2090                 2095                 2100             


Ala Gly  Leu Asn Asp His Gln  Tyr Tyr Pro Thr Asp  Asp Tyr Asn 
    2105                 2110                 2115             


Gly Ile  Lys Ser Val Pro Phe  Pro Ile Asp Gly Thr  Asp Asp Asp 
    2120                 2125                 2130             


Ile Asp  Leu Asp Leu Lys Asp  Val Asp Lys Ser Leu  Ala Thr Ala 
    2135                 2140                 2145             


Asp Trp  Thr Pro Pro Val Ala  Asp Gln Thr Cys Met  Ile Phe Ile 
    2150                 2155                 2160             


Ser Ala  Ala Pro Glu Asp Glu  Tyr Gly Gly Thr Thr  Ile Lys Ser 
    2165                 2170                 2175             


Thr Tyr  Thr Tyr Phe Glu Thr  Val Val Gly Val Leu  Val Gly Gly 
    2180                 2185                 2190             


Ala Lys  Ser Ile Pro Gly Leu  Ser Ile Asp Lys Asn  Ile Val Ile 
    2195                 2200                 2205             


Thr Asn  Asn Thr Met Asn Asp  Arg Asp Ala Ser Ala  Val Val Ser 
    2210                 2215                 2220             


Lys Leu  Leu Glu Leu Leu Pro  Thr Ala 
    2225                 2230         


<210>  9
<211>  511
<212>  PRT
<213>  Caenorhabditis elegans

<400>  9

Met Ala Gln Arg His Val Ser Val Gly Cys Phe Ser Thr Phe Ser Glu 
1               5                   10                  15      


Ala Glu Ala Lys Ser Ser Glu Glu Trp Lys Thr Ser Thr Lys Leu Glu 
            20                  25                  30          


Ala Leu Gly Ser Met Glu Gly Glu Leu Ala His Leu Leu Ser Thr Cys 
        35                  40                  45              


Lys Pro Glu Thr Leu Asn His Asn Lys Thr Glu Leu Ser Gly Phe Arg 
    50                  55                  60                  


Asn Leu Phe Ala Arg Phe Leu Arg Ala Lys Pro Thr Val Asp Trp Ser 
65                  70                  75                  80  


Lys Ile Glu Pro Leu Pro Glu Gly Ala Ile Arg Pro Tyr Lys Ser Leu 
                85                  90                  95      


Gly His Val Val Asp Lys Glu Leu Ile Ala Ser Gln Leu Arg Lys Leu 
            100                 105                 110         


Val Val Val Lys Leu Asn Gly Gly Leu Gly Thr Ser Met Gly Cys Lys 
        115                 120                 125             


Gly Pro Lys Ser Val Ile Ser Val Arg Asn Asp Leu Thr Phe Leu Asp 
    130                 135                 140                 


Leu Thr Met Gln Gln Ile Gln Thr Leu Asn Lys Thr Tyr Gly Val Asp 
145                 150                 155                 160 


Val Pro Leu Val Leu Met Asn Ser Phe Asn Thr Asn Glu Asp Thr Gln 
                165                 170                 175     


Lys Val Leu Lys Lys Tyr Ala Asn Val Lys Val Ser Val His Thr Phe 
            180                 185                 190         


Ser Gln Ser Gln Tyr Pro Arg Ile Asn Arg Glu Thr Leu Leu Pro Ile 
        195                 200                 205             


Val Lys Ser Leu Glu Ala Asp Asp Asn Glu Cys Trp Tyr Pro Pro Gly 
    210                 215                 220                 


His Gly Asn Phe Tyr Glu Ala Phe His Asn Ser Gly Leu Leu Asp Lys 
225                 230                 235                 240 


Phe Leu Ala Asp Gly Lys Glu Tyr Cys Phe Leu Ser Asn Ile Asp Asn 
                245                 250                 255     


Met Gly Ala Thr Val Asp Leu Ser Ile Leu Asn Phe Val Leu Asn Pro 
            260                 265                 270         


Ser Pro Asp Gln Thr Ala Pro Glu Phe Leu Met Glu Val Thr Asp Lys 
        275                 280                 285             


Thr Arg Ala Asp Val Lys Gly Gly Thr Leu Ile Gln Tyr Glu Gly Arg 
    290                 295                 300                 


Leu Met Leu Leu Glu Ile Ala Gln Val Pro Lys Asp Tyr Val Asp Glu 
305                 310                 315                 320 


Phe Lys Ser Ile Ser Lys Phe Arg Ile Phe Asn Thr Asn Asn Leu Trp 
                325                 330                 335     


Ala Lys Leu Asp Ala Met Arg Lys Ile Val Val Glu Asn Lys Leu Glu 
            340                 345                 350         


Met Glu Val Ile Val Asn Pro Lys His Leu Asp Arg Gly Leu Asp Val 
        355                 360                 365             


Ile Gln Leu Glu Thr Ala Ala Gly Ala Ala Ile Lys Ser Phe Ser Gly 
    370                 375                 380                 


Ala Val Gly Val Asn Val Pro Arg Ser Arg Phe Leu Pro Val Lys Lys 
385                 390                 395                 400 


Thr Ser Asp Leu Leu Leu Leu Met Ser Asn Leu Tyr Asp Ile Asp Asn 
                405                 410                 415     


Gly Ser Leu Thr Leu Ser His Gln Arg Ser Phe Pro Thr Thr Pro Leu 
            420                 425                 430         


Val Lys Leu Gly Ser Ser Phe Asp Lys Val Lys Asp Tyr Leu Gly Arg 
        435                 440                 445             


Phe Asn Gly Ile Pro Asp Leu Leu Glu Leu Asp His Leu Thr Val Ser 
    450                 455                 460                 


Gly Asp Val Trp Phe Gly Lys Asp Val Ser Leu Lys Gly Thr Val Ile 
465                 470                 475                 480 


Ile Ile Ala Asn His Gly Asp Arg Ile Asp Ile Pro Pro Gly Ser Ile 
                485                 490                 495     


Leu Glu Asn Lys Ile Val Ser Gly Asn Leu Arg Ile Leu Glu His 
            500                 505                 510     


<210>  10
<211>  2962
<212>  PRT
<213>  Caenorhabditis elegans

<400>  10

Met Ser Asp Glu Ser Glu Leu Gly Asn Gln Ser Glu Met Glu Ser Phe 
1               5                   10                  15      


Asn Glu Ser Asp Ser Pro Asp Glu Ala Asp Pro Asp Val Val Ile Ile 
            20                  25                  30          


His Asp Ile Val His Leu Arg Ala Ser Thr Thr Gly Asp Tyr Ser Gln 
        35                  40                  45              


Ser Glu Ile Gly Lys Leu Pro Glu Gln Asn Thr Phe Phe Leu Pro Gly 
    50                  55                  60                  


Arg Val Lys Arg Asn Ile Ser Ser Asn Asp Ser Asp Val Ile Ile Asp 
65                  70                  75                  80  


Glu Asp Glu Ile Pro Asp Gly Ala Ile Arg Ile Thr Ser Asp Thr His 
                85                  90                  95      


Phe Ile Gly Ser Ser Arg Gly Thr Ser Glu Leu Gly Asp Phe Glu Met 
            100                 105                 110         


Asp Glu Gln Glu Phe Leu Asn Ile Thr Ile Glu Glu Asn Gly Asn Glu 
        115                 120                 125             


Gln Glu Leu Glu Glu His Leu Arg Asn Ala Tyr Arg His Glu Glu Glu 
    130                 135                 140                 


Glu Cys Phe Glu Glu Glu Asp Asp Ile Ile Glu Leu Pro Pro Leu Pro 
145                 150                 155                 160 


Val Lys Pro Ala Val Lys Lys Pro Arg Arg Lys Leu Pro Lys His Leu 
                165                 170                 175     


Ser Ile Glu Ser Gly Ser Thr Ala Lys Thr Ser Lys Leu Val Ala Glu 
            180                 185                 190         


Val Val His Asp His Pro Arg Pro Val Asn Tyr Arg Met Lys Pro Ala 
        195                 200                 205             


Val Thr Asp Asp Gly Lys Val Val Glu Gln Lys Arg Thr Arg Val Thr 
    210                 215                 220                 


Arg Asn Ile Met Ser His Thr Ile Pro Gln Tyr His Leu Glu Gly Glu 
225                 230                 235                 240 


Glu Thr Glu Phe Gly Arg Val Lys Glu Ser Thr Leu Ser Lys Thr Ile 
                245                 250                 255     


Glu Gln Tyr Leu Gln Ala Gly Lys Leu Val Ser Pro Lys Cys Asp Gln 
            260                 265                 270         


Phe Arg Glu Gln Ile Val Ala Thr Ala Val Glu Tyr Asp Gly Ser Val 
        275                 280                 285             


Lys Met Leu Gln Phe Glu Asn Ala Leu Lys Lys His Ser Gly Lys Gln 
    290                 295                 300                 


Lys Arg Leu Lys Tyr Gln Thr Gly Trp Trp Lys Ala Ser Lys Ser His 
305                 310                 315                 320 


Tyr Glu Arg Ala Val Asn Gly Tyr Val Ala Met Pro Lys Thr Pro Val 
                325                 330                 335     


Leu Ser Ile Ser Asp Asp Pro Val Leu Tyr Lys His His Ser Leu Phe 
            340                 345                 350         


Pro Lys Asn Gln Ser Ser Glu Leu Glu Lys Ile Asn Val Gln Leu Arg 
        355                 360                 365             


Ile Arg Leu Asn Ser Lys Arg Gln Asn Asn Asp Val Ile Pro Asp Ser 
    370                 375                 380                 


Ser Tyr Phe Val Arg Glu Phe Leu Met Gln Lys His Ser Ile Ser Leu 
385                 390                 395                 400 


Arg Met Asn Arg Ser Ser Asp Leu Pro Glu Leu Phe Val Pro Pro Thr 
                405                 410                 415     


Leu Glu Cys Gly Tyr Phe Pro Gln Asp Ala Val Thr Val Gln Gln Gln 
            420                 425                 430         


Glu His Tyr Leu Met Met Arg Phe Glu Glu Ala Gln Asp Glu Tyr His 
        435                 440                 445             


Asn Ile Thr Tyr Arg Ser Ile Ala Pro Pro Val Glu Phe Gln Val Gly 
    450                 455                 460                 


Thr Ile Ser Ala Lys Glu Leu His Lys Phe His Arg Ile Gly Arg His 
465                 470                 475                 480 


Ile His Gly Phe Phe Val Val Trp Glu Asn Lys Phe Pro Glu Tyr Asp 
                485                 490                 495     


Glu Ser Gly Ile Cys Cys Pro Arg Lys Arg Tyr Leu Val Asp Met Phe 
            500                 505                 510         


Asn Leu Ile Cys Phe Pro Leu Tyr Thr Glu Tyr Glu Gln Trp Glu Ser 
        515                 520                 525             


Arg Leu Arg Val Ala Phe Asp Lys Thr Ile Val Tyr Asn Leu His Leu 
    530                 535                 540                 


Ser Glu Ile Leu Arg Cys Asn Arg Pro Val Phe Asp Phe Leu Ser Lys 
545                 550                 555                 560 


Asn Lys Ser Met Leu Gln Pro Ile Thr Leu Lys Glu Ile Val Tyr Leu 
                565                 570                 575     


Ile Glu Gln Ser Asn Met Asp Ala Lys Ser Phe Ala Val Lys Phe Gly 
            580                 585                 590         


Leu Arg Thr Phe Tyr Asp His Gly Arg Ala Thr Ser Asn Lys Asp Tyr 
        595                 600                 605             


Leu Ser Ala Phe Leu Ile Ile Thr Gly Gly Ala Lys Val Val Thr Glu 
    610                 615                 620                 


Glu Ile Asp Ser Glu Arg Leu Arg Val Phe Asn Ser Asp Tyr Met Glu 
625                 630                 635                 640 


Ser Gly Val Leu Thr Ser Ser Gly Asp Val Tyr Thr Phe Glu Phe Asp 
                645                 650                 655     


Lys Ile Pro Asn Asn Tyr Gln Ile Ser Ile Gly Cys Asn Ala Asp Gly 
            660                 665                 670         


Val Ala Glu Met Glu Gln Glu Asp Val Arg His Glu Leu Ser Glu Cys 
        675                 680                 685             


Ser Ser Arg Ile Thr Arg Ile Ile Gly Asp Ser Lys Lys Pro Glu Lys 
    690                 695                 700                 


Ile Ile Ala Arg Pro Leu Val Lys Thr Asn Gln Asn Asp Gly Met Lys 
705                 710                 715                 720 


Phe Phe Thr Arg Lys Asp Leu Leu Asn Tyr Arg Ile Lys Leu Tyr Asp 
                725                 730                 735     


Pro Ser Tyr Val Val Pro Arg Ala Lys Lys Gln Ile Val Asn Glu Pro 
            740                 745                 750         


Ala Lys Lys Lys Pro Gly Arg Lys Ser Lys Thr Arg Tyr Asp Ala Ala 
        755                 760                 765             


Met Gln Gln Asn Asn Phe Glu Ile Glu Gly Val Pro Ser Asp Val Asp 
    770                 775                 780                 


Ser Glu Phe Glu Gly Tyr Leu Ser Asp Ser Glu Asn Val Phe Gln Lys 
785                 790                 795                 800 


Pro Ser Lys Leu Met Arg Ser Thr Ser Ser Asp Ser Val Phe Ile Asp 
                805                 810                 815     


Tyr Gln Tyr Arg Glu Lys Met Phe Leu Asp Val Ser Trp Phe His Gln 
            820                 825                 830         


Gln Lys Met Ile Asp Arg Ser Leu Pro Pro Leu Lys Lys Arg Lys Arg 
        835                 840                 845             


Lys Met Asn Arg Ile Tyr His Lys His Ser Val Arg Tyr Thr Met Leu 
    850                 855                 860                 


Gln Ala Asn Gly Cys Ala Phe Thr Glu Met Tyr Arg Cys Tyr Asp Lys 
865                 870                 875                 880 


Ile Leu Pro Cys Gly Thr Lys Glu Ile Ala Arg Thr Lys Asn Ala Ile 
                885                 890                 895     


Arg Phe Pro His Arg Phe Arg Thr Tyr Asn Ile Pro Gln Val Tyr Gly 
            900                 905                 910         


Pro Gly Asp Lys Gln Leu Ile Thr Glu Val Phe Gly Val Val Lys Asp 
        915                 920                 925             


Val Ile Thr Arg Ala Thr Gly Phe Glu Ser Ala Ser Ile Arg Thr Ala 
    930                 935                 940                 


Asn Asp Ile Ala Gln Ala Val Tyr Asp Ala Asn Ile Ala Arg Arg Glu 
945                 950                 955                 960 


Leu Leu Glu Asn Leu Glu Pro Ser Asp Asn Gly Ile Leu Pro Ser Pro 
                965                 970                 975     


Ala Tyr Leu Ala Ile Glu Met Leu Ser His Gln Lys Met Ser Gly Arg 
            980                 985                 990         


Leu Cys Leu Glu Ser Ala Arg Lys  Asp Val Gln Asn Asn  Val Asp Lys 
        995                 1000                 1005             


Met Tyr  Asn Asp Tyr Met Asp  Leu Asp Pro Leu Asp  Lys Glu Leu 
    1010                 1015                 1020             


His Phe  Glu Ile Ser Gln Ser  Ile Arg Gln Ser Lys  Leu Asn Glu 
    1025                 1030                 1035             


Ser Leu  Glu Glu Tyr Glu Arg  Asn Arg Glu Arg Gln  Leu Ala Lys 
    1040                 1045                 1050             


Thr Leu  Lys Thr Val Pro Met  Asp Lys Arg Ser Gln  Ala Ala Leu 
    1055                 1060                 1065             


Ala Arg  Arg Glu Glu Lys Arg  Arg Glu Ser Arg Arg  Lys Leu Ala 
    1070                 1075                 1080             


Asp Lys  Tyr Ala Glu Gln Arg  Arg Met Met Ala Ser  Thr Arg Arg 
    1085                 1090                 1095             


Leu Glu  Lys Arg Thr Thr Gln  Lys Gln Val Asp Pro  Glu Thr Ile 
    1100                 1105                 1110             


Gln Arg  Leu Arg Arg Glu Asp  Glu Val Arg Lys Arg  Lys Arg Phe 
    1115                 1120                 1125             


Glu Glu  Glu Asp Arg Arg Gly  Met Ile Arg Arg Arg  Glu Glu Arg 
    1130                 1135                 1140             


Val Ala  Leu Gln Glu Lys Val  Asp Arg Met Leu Glu  Glu Gly Leu 
    1145                 1150                 1155             


Arg Leu  Glu Lys Val Arg Glu  Ala Glu Arg Ile Arg  Gln Gln Gln 
    1160                 1165                 1170             


Glu Glu  Glu Arg Ile Glu Met  Glu Thr Ile Leu Ile  Ser Arg Arg 
    1175                 1180                 1185             


Val Arg  Glu Glu Glu Glu Glu  Lys Met Arg Leu Glu  Arg Leu Arg 
    1190                 1195                 1200             


Lys Ala  Glu Arg Glu Arg Glu  Gln Glu Arg Leu Lys  Arg Glu Glu 
    1205                 1210                 1215             


Glu Glu  Glu Arg Lys Arg Leu  Glu Gln Leu Arg Glu  Ala Glu Lys 
    1220                 1225                 1230             


Leu Lys  Ala Glu Ile Glu Lys  Glu Asn Glu Arg Lys  Leu Gln Glu 
    1235                 1240                 1245             


Glu Arg  Thr Arg Lys Ala Leu  Glu Leu Glu Arg Lys  Ile Glu Glu 
    1250                 1255                 1260             


Ile Lys  Arg Val Ser Thr Leu  Lys Asp Met Phe Gly  Pro Leu Pro 
    1265                 1270                 1275             


Ile Ala  Lys Glu Asn Glu Gln  Thr Glu Lys Asp Phe  Gln Ile Leu 
    1280                 1285                 1290             


Leu Asp  Asp His Glu Leu Thr  Leu Leu Thr Ile Ser  Arg Asp Pro 
    1295                 1300                 1305             


Leu Asn  Glu Lys Tyr Gln Glu  Ala Arg Thr Glu Phe  Glu Arg Leu 
    1310                 1315                 1320             


Asp Ile  Lys Ser Met Leu Leu  Arg Lys Ala Glu Lys  Leu Ile Asp 
    1325                 1330                 1335             


Val Leu  Thr Ile His Tyr Asp  Val Pro Ile Glu Gln  Thr Cys Arg 
    1340                 1345                 1350             


Tyr Phe  Thr Ser Ser Ile Glu  Ser Asn Glu Asn Arg  Met Ala Val 
    1355                 1360                 1365             


Asn Glu  Gln Leu Asn Lys Leu  Phe Glu Asn Met Ala  Asn Cys Phe 
    1370                 1375                 1380             


Thr Phe  Asn Ile Gln Asp Gly  Glu Asn Gly Leu Gln  Ser Lys Arg 
    1385                 1390                 1395             


Lys Trp  Asp Phe Gln Phe Lys  Lys Cys Ala Val Phe  Asp Gly Val 
    1400                 1405                 1410             


Ser Gln  Ser Thr Val Asn Phe  Ile Glu Glu Lys Met  Arg Glu Asn 
    1415                 1420                 1425             


Thr Lys  Lys Lys His Leu Ala  Thr Pro Lys Thr Val  Ile Ser Ile 
    1430                 1435                 1440             


Asp Thr  Ser Leu Leu Lys Gln  Ser Leu Leu Arg Ser  His Ala Arg 
    1445                 1450                 1455             


Phe Asp  Pro Asp Ile Ser Leu  Tyr Ala Gln Asn His  Thr Ala Asn 
    1460                 1465                 1470             


Ser Ile  Gly Asp Val Thr Leu  Lys Met Ser Asn Tyr  Ser Leu Asp 
    1475                 1480                 1485             


Phe Ala  Thr Gln Ser Ile His  Asp Lys Glu Leu Ala  Glu Lys Ala 
    1490                 1495                 1500             


Thr Pro  Lys Lys Gly Pro Thr  Val Arg Arg His Ile  Lys Asn Leu 
    1505                 1510                 1515             


Phe Gly  Ser Glu Lys Val Ile  Val Arg Arg Ser Leu  Ala Ala Gly 
    1520                 1525                 1530             


Lys Pro  Ala Ser Leu Asn Ser  Glu Asp Ser Asp Ser  Glu Asp Ser 
    1535                 1540                 1545             


Arg Glu  Gly Ser Pro Val Ala  Glu Phe Leu Pro Thr  Asn Pro Val 
    1550                 1555                 1560             


Cys Ser  Phe Trp Lys Leu Val  Val Lys Ile Glu Asn  Ser Thr Thr 
    1565                 1570                 1575             


Asp Lys  Glu Lys Thr Glu Leu  Cys Glu Asp Leu Asp  Lys Leu Ile 
    1580                 1585                 1590             


Leu Arg  Lys Asp Asp Leu Phe  Ser Lys Ser Leu Lys  Trp Met Phe 
    1595                 1600                 1605             


Pro Leu  Leu Ala Thr Phe Tyr  Val Leu Leu Ser Asn  Ala Val Leu 
    1610                 1615                 1620             


Asn Glu  Asn Glu Glu Ile Ile  Ser Asp Lys Asn Gln  Thr Gly Val 
    1625                 1630                 1635             


Thr Lys  Asp Glu Ile Leu Lys  Ser Thr Ile Asn Asp  Leu Met Ile 
    1640                 1645                 1650             


Ile Ala  Ala Tyr Phe Glu Glu  Gly Ser Arg Glu Arg  Ser Asn Leu 
    1655                 1660                 1665             


Arg Lys  Met Ile Ser Met Asn  Gly Phe Ser Val Val  Phe Asn Arg 
    1670                 1675                 1680             


Val Ile  Leu Phe Ala Lys Lys  Thr Cys Thr Leu Ala  Lys Glu Leu 
    1685                 1690                 1695             


Glu Ser  Asn Ser Arg Ser Leu  Ser Gly Tyr Val Ile  Glu Asp Leu 
    1700                 1705                 1710             


Phe Glu  Ser Leu Leu Ala Glu  Ile Glu Arg Thr Met  Arg Gln Glu 
    1715                 1720                 1725             


Leu Gly  Ser Ser Val Arg Lys  Thr Gly Lys Leu Glu  Arg Asp Phe 
    1730                 1735                 1740             


Glu Glu  Ile Val Lys Leu Ile  Gln Asn Glu Lys Lys  Leu Ala Leu 
    1745                 1750                 1755             


Ser His  Lys Ser His Lys Asn  Asp Glu Asn Arg Arg  Phe Arg Leu 
    1760                 1765                 1770             


Asn Thr  Val Val Lys Trp Tyr  Asp Ala Ile Ile Cys  His Cys Lys 
    1775                 1780                 1785             


Glu Glu  Leu Thr Gln Ala Ile  Val Asp Ala Phe Pro  Leu Asn Ala 
    1790                 1795                 1800             


Ile Thr  Lys Asn Lys Glu Thr  Ser His Val Ala Met  Glu Asn Gly 
    1805                 1810                 1815             


Asp Asp  Glu Ala Met Leu Ser  Asp Thr Ser Asp Asn  Gln Met Ser 
    1820                 1825                 1830             


Thr Thr  Asp Tyr Gln Met Pro  Lys Asn Ile Cys Arg  Asn Ser Glu 
    1835                 1840                 1845             


Ile Phe  Pro Glu Asp Ala Phe  Ala Lys Ala Tyr Ala  Val Val Arg 
    1850                 1855                 1860             


Ile Pro  Ser Lys Lys Glu Arg  Ala Gln Met Leu Ser  Val Tyr Arg 
    1865                 1870                 1875             


Lys Lys  Asn Ala Gln Ser Gly  Cys Val Glu Asn Lys  Gly Leu Ser 
    1880                 1885                 1890             


Arg Met  Pro Lys Phe Glu Glu  Pro Phe Val Asp Ser  Val Trp Arg 
    1895                 1900                 1905             


Thr Ile  Glu Lys Arg Ile Asn  Asn Met Thr His Ser  Glu Glu Lys 
    1910                 1915                 1920             


Gln Ile  Lys Arg Phe Ile Pro  Val Ser Arg Ser His  Lys Leu Asn 
    1925                 1930                 1935             


Glu Lys  Val Lys Phe Tyr Ala  Met Val Met Ile Gln  Glu Arg Asp 
    1940                 1945                 1950             


Ser Arg  Asp Thr Arg Leu Phe  Asn Ser Lys Phe Gln  Asp Asp Asn 
    1955                 1960                 1965             


Leu Trp  His Cys Tyr Ser Lys  Ser Ser Leu Asn His  Glu Lys Met 
    1970                 1975                 1980             


Glu Ser  Arg Ile Leu Gln His  Ile Glu His Thr Val  Leu Ser Lys 
    1985                 1990                 1995             


Ser Asn  Phe Asn Gln Met Lys  Trp Ser Val Gln Cys  Val Asn Gly 
    2000                 2005                 2010             


Asn Lys  Lys Asp Ala Ile His  Tyr Phe Thr Asp Leu  Tyr Lys Tyr 
    2015                 2020                 2025             


Arg Ser  Glu Ser Glu Phe Arg  Ser Ala Leu Ser Cys  Gly Lys Leu 
    2030                 2035                 2040             


Lys Phe  Asn Phe Lys Val Tyr  Thr His Leu Trp Phe  Met Gly Asn 
    2045                 2050                 2055             


Leu Leu  Pro Thr Ser Tyr Asn  Pro Asp Ser His Asp  Asp Lys Leu 
    2060                 2065                 2070             


Phe Val  Pro Cys Ser Gly Cys  Thr Ser Gly Asp Val  Ile Ile Ile 
    2075                 2080                 2085             


His Lys  Cys Thr Cys Ala Tyr  His Asn Asp Thr Phe  Ser Asp Lys 
    2090                 2095                 2100             


Phe Ile  Tyr Ala Asn Thr Ser  Leu Pro Val Gly Ile  Asp Lys Val 
    2105                 2110                 2115             


Thr Arg  Leu Val Gly Arg Phe  Val Cys Glu His Gly  Pro Ser Ser 
    2120                 2125                 2130             


Phe Leu  Ile Leu Glu His Cys  Ser Ala Asn Val Asp  Ala Asn Ile 
    2135                 2140                 2145             


Pro Phe  Glu Ser Glu Asn Val  Glu Phe Ser Ala Glu  Leu Arg Ile 
    2150                 2155                 2160             


Val Lys  Arg Lys Thr Met His  Ser Gln Leu Val Lys  Thr Phe Ala 
    2165                 2170                 2175             


Glu Glu  His Thr His Leu Arg  Asp Ala Ser Arg His  Arg Ala Ile 
    2180                 2185                 2190             


Ser Thr  Val Thr Leu Asp Ser  Ser Gly Ser Gly Arg  Ser Thr Arg 
    2195                 2200                 2205             


Cys Glu  Ile Phe Glu Asp Ser  Pro Ser Glu Asp Glu  Asn Asp Glu 
    2210                 2215                 2220             


Asn Gln  Leu Asp Thr Thr Arg  Ile Gly Arg Lys Ile  Asp Pro Ile 
    2225                 2230                 2235             


Ile Val  Asp Ser Asp Lys Ala  Tyr Leu Ile Ala Glu  Gly Glu Arg 
    2240                 2245                 2250             


Met Ala  Leu Arg Ile Lys Arg  Leu Leu Asp Pro Glu  Leu Gln Lys 
    2255                 2260                 2265             


Phe Arg  Ser Lys Asn Phe Val  Ser Arg Ser Lys Ser  Val Asp Ala 
    2270                 2275                 2280             


Pro Lys  Thr Ser Lys Gln Lys  Thr Val Ile Arg Arg  Ser Gln Ser 
    2285                 2290                 2295             


Val Cys  Asp Leu Asn Asp Val  Asn Glu Tyr Ala Gln  Lys Lys Val 
    2300                 2305                 2310             


Arg Asn  Thr Lys Asp Ser Phe  Ala Thr Leu Phe Arg  Asp His Glu 
    2315                 2320                 2325             


Tyr Ser  Thr Arg Arg Thr Tyr  Glu Glu Gln Leu Asn  Asn Glu Leu 
    2330                 2335                 2340             


Leu Asp  Val Val Thr Thr Phe  Gly Gly Ala Ser Asn  Val Ser Ala 
    2345                 2350                 2355             


Asp Lys  Lys Tyr Asn Ile Leu  Ala Ser Ile Leu Ala  Phe Glu Lys 
    2360                 2365                 2370             


Glu Val  Gln Leu Val Asn Asp  Lys Asn Gly Glu Leu  Phe Lys Thr 
    2375                 2380                 2385             


Val Ser  Asn Leu Val Gln Arg  Asn Ser Leu Gln His  Val Lys Gly 
    2390                 2395                 2400             


Val Ile  Leu Ala Glu Asp Asn  Gln Thr Leu Arg Ser  Thr Asp Asn 
    2405                 2410                 2415             


Thr Ser  Glu Val Phe Pro Glu  Ser Lys Ala Val Asn  Glu Tyr Leu 
    2420                 2425                 2430             


Lys Phe  Glu Ile Tyr Lys Arg  Lys Met Met Val Asn  Ala Lys Leu 
    2435                 2440                 2445             


Met Ala  Asp Thr Val Lys Asp  Leu Lys Leu Lys His  Ala Glu Tyr 
    2450                 2455                 2460             


Arg Pro  Phe Ala Lys Leu Ile  Ala Thr Tyr Asp Ser  Ile Phe Lys 
    2465                 2470                 2475             


Phe Asn  Val Tyr Leu Phe Glu  His Phe Leu Asn Cys  Ile Ser Lys 
    2480                 2485                 2490             


His Val  Phe Asn Pro Tyr Ala  Ile Tyr Cys Glu Glu  Thr Arg Pro 
    2495                 2500                 2505             


Thr Gly  Thr Glu Leu Ser Lys  Phe Gln Leu Thr Leu  Lys Leu Ile 
    2510                 2515                 2520             


Glu Thr  Ser Met Pro Thr Val  Leu Ser Met Leu Phe  Asn Thr Glu 
    2525                 2530                 2535             


Pro Leu  Arg Arg Gln Leu Ser  Glu Leu Ser Glu Ile  His Lys Lys 
    2540                 2545                 2550             


Val Arg  Ser Glu Asp Leu Ala  Cys Thr Ile Ala Ser  Leu Cys Arg 
    2555                 2560                 2565             


Tyr Ala  Ile Glu Arg Ile Arg  Ile Pro Gln Thr Ala  Asp Lys Arg 
    2570                 2575                 2580             


Leu Cys  Asp Phe Ser Trp Leu  Asn Ser Ala Glu Asp  His Arg Glu 
    2585                 2590                 2595             


Thr Val  Ser Phe Ile Arg Leu  Thr Leu Glu His Thr  Leu Pro Asp 
    2600                 2605                 2610             


Met Lys  Thr Glu Asn Glu Gln  Thr Arg Phe Val Glu  Phe Leu Lys 
    2615                 2620                 2625             


Glu Ala  Glu Gly Phe His Phe  Ser Tyr Lys Phe Val  Glu Ala Gln 
    2630                 2635                 2640             


Cys Lys  Thr Phe Val Arg Asn  His Gly Asp Ser Lys  Gln Ala Phe 
    2645                 2650                 2655             


Phe Thr  Ala Phe Tyr Asn Gln  Asn Glu Ala Phe Tyr  Gly Ser Leu 
    2660                 2665                 2670             


Gln Lys  Phe Met Ser Asn Gly  Thr Ile Asp Pro Lys  Met Lys Leu 
    2675                 2680                 2685             


Tyr Tyr  Gln His Gln Ala Phe  Leu Arg Leu His Asn  Ile Val Lys 
    2690                 2695                 2700             


Lys Arg  Ser His Ile Ile Thr  Ser Asp Asp Tyr His  Arg Ser Ser 
    2705                 2710                 2715             


Asp Val  Cys Lys Ala Met Leu  Leu Ser Glu Ile Val  Ser Asn Pro 
    2720                 2725                 2730             


Lys Ile  Ala Gln Glu Ala Tyr  Ile Ser Gly Ser Val  Leu Asp Arg 
    2735                 2740                 2745             


Met Tyr  Thr Ser Leu Cys Lys  Ile Lys Ala Lys Met  Pro Leu Ile 
    2750                 2755                 2760             


Ser Pro  Ser Tyr Ile Gly Thr  Ser Leu Thr Cys Phe  Glu Asp Glu 
    2765                 2770                 2775             


Leu Leu  Phe Ser Ala Val Arg  Glu Ala Lys Val His  Thr Asp Thr 
    2780                 2785                 2790             


Arg Val  Val Phe Arg Ser Lys  Ser Cys Met Arg Pro  Asn Glu Lys 
    2795                 2800                 2805             


Ala Gly  Asp Ala Asn Phe Lys  Thr Cys Lys Val Thr  Leu Leu Val 
    2810                 2815                 2820             


Asn Leu  Glu Thr Ala Leu Leu  Ser Met Val Phe Lys  Ser Arg Asp 
    2825                 2830                 2835             


Gln Ser  Glu Ile Asp Lys Asp  Asp Arg Leu Asp Ile  Asp Ile Leu 
    2840                 2845                 2850             


Asp Glu  Glu Val Ile Lys Pro  Ile Ile Asp Trp Asn  Arg Ile Phe 
    2855                 2860                 2865             


Glu Thr  Phe Ile Gln Pro Thr  Tyr Asn Thr Leu Phe  Ser Arg Met 
    2870                 2875                 2880             


Glu Lys  Arg Glu Arg Val Ser  Ile Leu Pro Glu Asn  Pro Leu Gly 
    2885                 2890                 2895             


Arg Leu  Glu Asn Tyr Ala Phe  Thr Asn Pro Asn Gln  Asp Lys Asp 
    2900                 2905                 2910             


Cys Gln  Ala Val Leu Glu Tyr  Ile Asp Val Ala Ser  Asp Thr Asp 
    2915                 2920                 2925             


Ala Glu  Glu Ser Ile Glu Asp  Pro Leu Asp Ile Val  Glu Met Thr 
    2930                 2935                 2940             


Leu Lys  Arg Ala Leu Pro Arg  Ser Met Ser Pro Ser  Ser Lys Arg 
    2945                 2950                 2955             


Arg Arg  Met Arg 
    2960         


