                         SEQUENCE LISTING

<110>  Ottawa Hospital Research Institute
 
<120>  COMPOSITIONS AND METHODS FOR ENHANCING VIRUS REPLICATION

<130>  PAT 7522W-90

<140>  not yet available
<141>  2014-06-16

<150>  US 61/835,446
<151>  2013-06-14


<160>  20

<170>  PatentIn version 3.5

<210>  1
<211>  19
<212>  PRT
<213>  Mus musculus

<400>  1

Met Lys Cys Ser Trp Val Ile Phe Phe Leu Met Ala Val Val Thr Gly 
1               5                   10                  15      


Val Asn Ser 
            


<210>  2
<211>  155
<212>  PRT
<213>  Homo sapiens

<400>  2

Met Ala Ala Gly Ser Ile Thr Thr Leu Pro Ala Leu Pro Glu Asp Gly 
1               5                   10                  15      


Gly Ser Gly Ala Phe Pro Pro Gly His Phe Lys Asp Pro Lys Arg Leu 
            20                  25                  30          


Tyr Cys Lys Asn Gly Gly Phe Phe Leu Arg Ile His Pro Asp Gly Arg 
        35                  40                  45              


Val Asp Gly Val Arg Glu Lys Ser Asp Pro His Ile Lys Leu Gln Leu 
    50                  55                  60                  


Gln Ala Glu Glu Arg Gly Val Val Ser Ile Lys Gly Val Cys Ala Asn 
65                  70                  75                  80  


Arg Tyr Leu Ala Met Lys Glu Asp Gly Arg Leu Leu Ala Ser Lys Cys 
                85                  90                  95      


Val Thr Asp Glu Cys Phe Phe Phe Glu Arg Leu Glu Ser Asn Asn Tyr 
            100                 105                 110         


Asn Thr Tyr Arg Ser Arg Lys Tyr Thr Ser Trp Tyr Val Ala Leu Lys 
        115                 120                 125             


Arg Thr Gly Gln Tyr Lys Leu Gly Ser Lys Thr Gly Pro Gly Gln Lys 
    130                 135                 140                 


Ala Ile Leu Phe Leu Pro Met Ser Ala Lys Ser 
145                 150                 155 


<210>  3
<211>  154
<212>  PRT
<213>  Mus musculus

<400>  3

Met Ala Ala Ser Gly Ile Thr Ser Leu Pro Ala Leu Pro Glu Asp Gly 
1               5                   10                  15      


Gly Ala Ala Phe Pro Pro Gly His Phe Lys Asp Pro Lys Arg Leu Tyr 
            20                  25                  30          


Cys Lys Asn Gly Gly Phe Phe Leu Arg Ile His Pro Asp Gly Arg Val 
        35                  40                  45              


Asp Gly Val Arg Glu Lys Ser Asp Pro His Val Lys Leu Gln Leu Gln 
    50                  55                  60                  


Ala Glu Glu Arg Gly Val Val Ser Ile Lys Gly Val Cys Ala Asn Arg 
65                  70                  75                  80  


Tyr Leu Ala Met Lys Glu Asp Gly Arg Leu Leu Ala Ser Lys Cys Val 
                85                  90                  95      


Thr Glu Glu Cys Phe Phe Phe Glu Arg Leu Glu Ser Asn Asn Tyr Asn 
            100                 105                 110         


Thr Tyr Arg Ser Arg Lys Tyr Ser Ser Trp Tyr Val Ala Leu Lys Arg 
        115                 120                 125             


Thr Gly Gln Tyr Lys Leu Gly Ser Lys Thr Gly Pro Gly Gln Lys Ala 
    130                 135                 140                 


Ile Leu Phe Leu Pro Met Ser Ala Lys Ser 
145                 150                 


<210>  4
<211>  158
<212>  PRT
<213>  Gallus gallus

<400>  4

Met Ala Ala Gly Ala Ala Gly Ser Ile Thr Thr Leu Pro Ala Leu Pro 
1               5                   10                  15      


Asp Asp Gly Gly Gly Gly Ala Phe Pro Pro Gly His Phe Lys Asp Pro 
            20                  25                  30          


Lys Arg Leu Tyr Cys Lys Asn Gly Gly Phe Phe Leu Arg Ile Asn Pro 
        35                  40                  45              


Asp Gly Arg Val Asp Gly Val Arg Glu Lys Ser Asp Pro His Ile Lys 
    50                  55                  60                  


Leu Gln Leu Gln Ala Glu Glu Arg Gly Val Val Ser Ile Lys Gly Val 
65                  70                  75                  80  


Ser Ala Asn Arg Phe Leu Ala Met Lys Glu Asp Gly Arg Leu Leu Ala 
                85                  90                  95      


Leu Lys Cys Ala Thr Glu Glu Cys Phe Phe Phe Glu Arg Leu Glu Ser 
            100                 105                 110         


Asn Asn Tyr Asn Thr Tyr Arg Ser Arg Lys Tyr Ser Asp Trp Tyr Val 
        115                 120                 125             


Ala Leu Lys Arg Thr Gly Gln Tyr Lys Pro Gly Pro Lys Thr Gly Pro 
    130                 135                 140                 


Gly Gln Lys Ala Ile Leu Phe Leu Pro Met Ser Ala Lys Ser 
145                 150                 155             


<210>  5
<211>  156
<212>  PRT
<213>  Monodelphis domestica

<400>  5

Met Ala Ala Gly Ser Ile Thr Thr Leu Pro Ala Leu Ser Gly Asp Gly 
1               5                   10                  15      


Gly Gly Gly Gly Ala Phe Pro Pro Gly His Phe Lys Asp Pro Lys Arg 
            20                  25                  30          


Leu Tyr Cys Lys Asn Gly Gly Phe Phe Leu Arg Ile His Pro Asp Gly 
        35                  40                  45              


Arg Val Asp Gly Ile Arg Glu Lys Ser Asp Pro Asn Ile Lys Leu Gln 
    50                  55                  60                  


Leu Gln Ala Glu Glu Arg Gly Val Val Ser Ile Lys Gly Val Cys Ala 
65                  70                  75                  80  


Asn Arg Tyr Leu Ala Met Lys Glu Asp Gly Arg Leu Leu Ala Leu Lys 
                85                  90                  95      


Tyr Val Thr Glu Glu Cys Phe Phe Phe Glu Arg Leu Glu Ser Asn Asn 
            100                 105                 110         


Tyr Asn Thr Tyr Arg Ser Arg Lys Tyr Ser Asn Trp Tyr Val Ala Leu 
        115                 120                 125             


Lys Arg Thr Gly Gln Tyr Lys Leu Gly Ser Lys Thr Gly Pro Gly Gln 
    130                 135                 140                 


Lys Ala Ile Leu Phe Leu Pro Met Ser Ala Lys Ser 
145                 150                 155     


<210>  6
<211>  155
<212>  PRT
<213>  Ovis aries

<400>  6

Met Ala Ala Gly Ser Ile Thr Thr Leu Pro Ala Leu Pro Glu Asp Gly 
1               5                   10                  15      


Gly Ser Ser Ala Phe Pro Pro Gly His Phe Lys Asp Pro Lys Arg Leu 
            20                  25                  30          


Tyr Cys Lys Asn Gly Gly Phe Phe Leu Arg Ile His Pro Asp Gly Arg 
        35                  40                  45              


Val Asp Gly Val Arg Glu Lys Ser Asp Pro His Ile Lys Leu Gln Leu 
    50                  55                  60                  


Gln Ala Glu Glu Arg Gly Val Val Ser Ile Lys Gly Val Cys Ala Asn 
65                  70                  75                  80  


Arg Tyr Leu Ala Met Lys Glu Asp Gly Arg Leu Leu Ala Ser Lys Cys 
                85                  90                  95      


Val Thr Asp Glu Cys Phe Phe Phe Glu Arg Leu Glu Ser Asn Asn Tyr 
            100                 105                 110         


Asn Thr Tyr Arg Ser Arg Lys Tyr Ser Ser Trp Tyr Val Ala Leu Lys 
        115                 120                 125             


Arg Thr Gly Gln Tyr Lys Leu Gly Pro Lys Thr Gly Pro Gly Gln Lys 
    130                 135                 140                 


Ala Ile Leu Phe Leu Pro Met Ser Ala Lys Ser 
145                 150                 155 


<210>  7
<211>  155
<212>  PRT
<213>  Bos taurus

<400>  7

Met Ala Ala Gly Ser Ile Thr Thr Leu Pro Ser Leu Pro Glu Asp Gly 
1               5                   10                  15      


Gly Ser Gly Ala Phe Pro Pro Gly His Phe Lys Asp Pro Lys Arg Leu 
            20                  25                  30          


Tyr Cys Lys Asn Gly Gly Phe Phe Leu Arg Ile His Pro Asp Gly Arg 
        35                  40                  45              


Val Asp Gly Val Arg Glu Lys Ser Asp Pro His Ile Lys Leu Gln Leu 
    50                  55                  60                  


Gln Ala Glu Glu Arg Gly Val Val Ser Ile Lys Gly Val Cys Ala Asn 
65                  70                  75                  80  


Arg Tyr Leu Ala Met Lys Glu Asp Gly Arg Leu Leu Ala Ser Lys Cys 
                85                  90                  95      


Val Thr Asp Glu Cys Phe Phe Phe Glu Arg Leu Glu Ser Asn Asn Tyr 
            100                 105                 110         


Asn Thr Tyr Arg Ser Arg Lys Tyr Ser Ser Trp Tyr Val Ala Leu Lys 
        115                 120                 125             


Arg Thr Gly Gln Tyr Lys Leu Gly Pro Lys Thr Gly Pro Gly Gln Lys 
    130                 135                 140                 


Ala Ile Leu Phe Leu Pro Met Ser Ala Lys Ser 
145                 150                 155 


<210>  8
<211>  154
<212>  PRT
<213>  Rattus norvegicus

<400>  8

Met Ala Ala Gly Ser Ile Thr Ser Leu Pro Ala Leu Pro Glu Asp Gly 
1               5                   10                  15      


Gly Gly Ala Phe Pro Pro Gly His Phe Lys Asp Pro Lys Arg Leu Tyr 
            20                  25                  30          


Cys Lys Asn Gly Gly Phe Phe Leu Arg Ile His Pro Asp Gly Arg Val 
        35                  40                  45              


Asp Gly Val Arg Glu Lys Ser Asp Pro His Val Lys Leu Gln Leu Gln 
    50                  55                  60                  


Ala Glu Glu Arg Gly Val Val Ser Ile Lys Gly Val Cys Ala Asn Arg 
65                  70                  75                  80  


Tyr Leu Ala Met Lys Glu Asp Gly Arg Leu Leu Ala Ser Lys Cys Val 
                85                  90                  95      


Thr Glu Glu Cys Phe Phe Phe Glu Arg Leu Glu Ser Asn Asn Tyr Asn 
            100                 105                 110         


Thr Tyr Arg Ser Arg Lys Tyr Ser Ser Trp Tyr Val Ala Leu Lys Arg 
        115                 120                 125             


Thr Gly Gln Tyr Lys Leu Gly Ser Lys Thr Gly Pro Gly Gln Lys Ala 
    130                 135                 140                 


Ile Leu Phe Leu Pro Met Ser Ala Lys Ser 
145                 150                 


<210>  9
<211>  147
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  recombinant human protein

<400>  9

Met Pro Ala Leu Pro Glu Asp Gly Gly Ser Gly Ala Phe Pro Pro Gly 
1               5                   10                  15      


His Phe Lys Asp Pro Lys Arg Leu Tyr Cys Lys Asn Gly Gly Phe Phe 
            20                  25                  30          


Leu Arg Ile His Pro Asp Gly Arg Val Asp Gly Val Arg Glu Lys Ser 
        35                  40                  45              


Asp Pro His Ile Lys Leu Gln Leu Gln Ala Glu Glu Arg Gly Val Val 
    50                  55                  60                  


Ser Ile Lys Gly Val Cys Ala Asn Arg Tyr Leu Ala Met Lys Glu Asp 
65                  70                  75                  80  


Gly Arg Leu Leu Ala Ser Lys Cys Val Thr Asp Glu Cys Phe Phe Phe 
                85                  90                  95      


Glu Arg Leu Glu Ser Asn Asn Tyr Asn Thr Tyr Arg Ser Arg Lys Tyr 
            100                 105                 110         


Thr Ser Trp Tyr Val Ala Leu Lys Arg Thr Gly Gln Tyr Lys Leu Gly 
        115                 120                 125             


Ser Lys Thr Gly Pro Gly Gln Lys Ala Ile Leu Phe Leu Pro Met Ser 
    130                 135                 140                 


Ala Lys Ser 
145         


<210>  10
<211>  154
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  recombinant human protein

<400>  10

Ala Ala Gly Ser Ile Thr Thr Leu Pro Ala Leu Pro Glu Asp Gly Gly 
1               5                   10                  15      


Ser Gly Ala Phe Pro Pro Gly His Phe Lys Asp Pro Lys Arg Leu Tyr 
            20                  25                  30          


Cys Lys Asn Gly Gly Phe Phe Leu Arg Ile His Pro Asp Gly Arg Val 
        35                  40                  45              


Asp Gly Val Arg Glu Lys Ser Asp Pro His Ile Lys Leu Gln Leu Gln 
    50                  55                  60                  


Ala Glu Glu Arg Gly Val Val Ser Ile Lys Gly Val Cys Ala Asn Arg 
65                  70                  75                  80  


Tyr Leu Ala Met Lys Glu Asp Gly Arg Leu Leu Ala Ser Lys Cys Val 
                85                  90                  95      


Thr Asp Glu Cys Phe Phe Phe Glu Arg Leu Glu Ser Asn Asn Tyr Asn 
            100                 105                 110         


Thr Tyr Arg Ser Arg Lys Tyr Thr Ser Trp Tyr Val Ala Leu Lys Arg 
        115                 120                 125             


Thr Gly Gln Tyr Lys Leu Gly Ser Lys Thr Gly Pro Gly Gln Lys Ala 
    130                 135                 140                 


Ile Leu Phe Leu Pro Met Ser Ala Lys Ser 
145                 150                 


<210>  11
<211>  154
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  recombinant mouse protein

<400>  11

Met Ala Ala Ser Gly Ile Thr Ser Leu Pro Ala Leu Pro Glu Asp Gly 
1               5                   10                  15      


Gly Ala Ala Phe Pro Pro Gly His Phe Lys Asp Pro Lys Arg Leu Tyr 
            20                  25                  30          


Cys Lys Asn Gly Gly Phe Phe Leu Arg Ile His Pro Asp Gly Arg Val 
        35                  40                  45              


Asp Gly Val Arg Glu Lys Ser Asp Pro His Val Lys Leu Gln Leu Gln 
    50                  55                  60                  


Ala Glu Glu Arg Gly Val Val Ser Ile Lys Gly Val Cys Ala Asn Arg 
65                  70                  75                  80  


Tyr Leu Ala Met Lys Glu Asp Gly Arg Leu Leu Ala Ser Lys Cys Val 
                85                  90                  95      


Thr Glu Glu Cys Phe Phe Phe Glu Arg Leu Glu Ser Asn Asn Tyr Asn 
            100                 105                 110         


Thr Tyr Arg Ser Arg Lys Tyr Ser Ser Trp Tyr Val Ala Leu Lys Arg 
        115                 120                 125             


Thr Gly Gln Tyr Lys Leu Gly Ser Lys Thr Gly Pro Gly Gln Lys Ala 
    130                 135                 140                 


Ile Leu Phe Leu Pro Met Ser Ala Lys Ser 
145                 150                 


<210>  12
<211>  146
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  recombinant mouse protein

<400>  12

Met Pro Ala Leu Pro Glu Asp Gly Gly Ala Ala Phe Pro Pro Gly His 
1               5                   10                  15      


Phe Lys Asp Pro Lys Arg Leu Tyr Cys Lys Asn Gly Gly Phe Phe Leu 
            20                  25                  30          


Arg Ile His Pro Asp Gly Arg Val Asp Gly Val Arg Glu Lys Ser Asp 
        35                  40                  45              


Pro His Val Lys Leu Gln Leu Gln Ala Glu Glu Arg Gly Val Val Ser 
    50                  55                  60                  


Ile Lys Gly Val Cys Ala Asn Arg Tyr Leu Ala Met Lys Glu Asp Gly 
65                  70                  75                  80  


Arg Leu Leu Ala Ser Lys Cys Val Thr Glu Glu Cys Phe Phe Phe Glu 
                85                  90                  95      


Arg Leu Glu Ser Asn Asn Tyr Asn Thr Tyr Arg Ser Arg Lys Tyr Ser 
            100                 105                 110         


Ser Trp Tyr Val Ala Leu Lys Arg Thr Gly Gln Tyr Lys Leu Gly Ser 
        115                 120                 125             


Lys Thr Gly Pro Gly Gln Lys Ala Ile Leu Phe Leu Pro Met Ser Ala 
    130                 135                 140                 


Lys Ser 
145     


<210>  13
<211>  159
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Concensus sequence for SEQ ID NO: 2-12


<220>
<221>  MISC_FEATURE
<222>  (1)..(1)
<223>  Xaa present or absent, and, if present, may be Met

<220>
<221>  MISC_FEATURE
<222>  (2)..(2)
<223>  Xaa present or absent, and, if present, may be Ala

<220>
<221>  MISC_FEATURE
<222>  (3)..(3)
<223>  Xaa present or absent, and, if present, may be Ala

<220>
<221>  MISC_FEATURE
<222>  (4)..(4)
<223>  Xaa present or absent, and, if present, may be Met or Gly

<220>
<221>  MISC_FEATURE
<222>  (5)..(5)
<223>  Xaa present or absent, and, if present, may be Ala

<220>
<221>  MISC_FEATURE
<222>  (6)..(6)
<223>  Xaa present or absent, and, if present, may be Ala

<220>
<221>  MISC_FEATURE
<222>  (7)..(7)
<223>  Xaa present or absent, and, if present, may be Gly or Ser

<220>
<221>  MISC_FEATURE
<222>  (8)..(8)
<223>  Xaa present or absent, and, if present, may be Ser or Gly

<220>
<221>  MISC_FEATURE
<222>  (9)..(9)
<223>  Xaa present or absent, and, if present, may be Ile

<220>
<221>  MISC_FEATURE
<222>  (10)..(10)
<223>  Xaa present or absent, and, if present, may be Thr

<220>
<221>  MISC_FEATURE
<222>  (11)..(11)
<223>  Xaa present or absent, and, if present, may be Thr or Ser

<220>
<221>  MISC_FEATURE
<222>  (12)..(12)
<223>  Xaa may be Leu or Met

<220>
<221>  MISC_FEATURE
<222>  (14)..(14)
<223>  Xaa may be Ala or Ser

<220>
<221>  MISC_FEATURE
<222>  (16)..(16)
<223>  Xaa may be Pro or Ser

<220>
<221>  MISC_FEATURE
<222>  (17)..(17)
<223>  Xaa may be Glu, Asp or Gly

<220>
<221>  MISC_FEATURE
<222>  (21)..(21)
<223>  Xaa may be present or absent, and, if present may be Ser or Gly

<220>
<221>  MISC_FEATURE
<222>  (22)..(22)
<223>  Xaa may be present or absent, and, if present, may be Gly or Ser

<220>
<221>  MISC_FEATURE
<222>  (23)..(23)
<223>  Xaa may be present or absent, and, if present, may be Gly or Ala

<220>
<221>  MISC_FEATURE
<222>  (48)..(48)
<223>  Xaa may be His or Asn

<220>
<221>  MISC_FEATURE
<222>  (56)..(56)
<223>  Xaa may be Val or Ile

<220>
<221>  MISC_FEATURE
<222>  (63)..(63)
<223>  Xaa may be His or Asn

<220>
<221>  MISC_FEATURE
<222>  (64)..(64)
<223>  Xaa may be Ile or Val

<220>
<221>  MISC_FEATURE
<222>  (82)..(82)
<223>  Xaa may be Cys or Ser

<220>
<221>  MISC_FEATURE
<222>  (86)..(86)
<223>  Xaa may beTyr or Phe

<220>
<221>  MISC_FEATURE
<222>  (98)..(98)
<223>  Xaa may be Ser or Leu

<220>
<221>  MISC_FEATURE
<222>  (100)..(100)
<223>  Xaa may be Cys or Tyr

<220>
<221>  MISC_FEATURE
<222>  (101)..(101)
<223>  Xaa may be Val or Ala

<220>
<221>  MISC_FEATURE
<222>  (103)..(103)
<223>  Xaa may be Glu or Asp

<220>
<221>  MISC_FEATURE
<222>  (125)..(125)
<223>  Xaa may be Ser or Thr

<220>
<221>  MISC_FEATURE
<222>  (126)..(126)
<223>  Xaa may be Ser, Asp or Asn

<220>
<221>  MISC_FEATURE
<222>  (139)..(139)
<223>  Xaa may be Leu or Pro

<220>
<221>  MISC_FEATURE
<222>  (141)..(141)
<223>  Xaa may be Ser or Pro

<400>  13

Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Pro Xaa Leu Xaa 
1               5                   10                  15      


Xaa Asp Gly Gly Xaa Xaa Xaa Ala Phe Pro Pro Gly His Phe Lys Asp 
            20                  25                  30          


Pro Lys Arg Leu Tyr Cys Lys Asn Gly Gly Phe Phe Leu Arg Ile Xaa 
        35                  40                  45              


Pro Asp Gly Arg Val Asp Gly Xaa Arg Glu Lys Ser Asp Pro Xaa Xaa 
    50                  55                  60                  


Lys Leu Gln Leu Gln Ala Glu Glu Arg Gly Val Val Ser Ile Lys Gly 
65                  70                  75                  80  


Val Xaa Ala Asn Arg Xaa Leu Ala Met Lys Glu Asp Gly Arg Leu Leu 
                85                  90                  95      


Ala Xaa Lys Xaa Xaa Thr Xaa Glu Cys Phe Phe Phe Glu Arg Leu Glu 
            100                 105                 110         


Ser Asn Asn Tyr Asn Thr Tyr Arg Ser Arg Lys Tyr Xaa Xaa Trp Tyr 
        115                 120                 125             


Val Ala Leu Lys Arg Thr Gly Gln Tyr Lys Xaa Gly Xaa Lys Thr Gly 
    130                 135                 140                 


Pro Gly Gln Lys Ala Ile Leu Phe Leu Pro Met Ser Ala Lys Ser 
145                 150                 155                 


<210>  14
<211>  288
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  recombinant human protein

<400>  14

Met Val Gly Val Gly Gly Gly Asp Val Glu Asp Val Thr Pro Arg Pro 
1               5                   10                  15      


Gly Gly Cys Gln Ile Ser Gly Arg Gly Ala Arg Gly Cys Asn Gly Ile 
            20                  25                  30          


Pro Gly Ala Ala Ala Trp Glu Ala Ala Leu Pro Arg Arg Arg Pro Arg 
        35                  40                  45              


Arg His Pro Ser Val Asn Pro Arg Ser Arg Ala Ala Gly Ser Pro Arg 
    50                  55                  60                  


Thr Arg Gly Arg Arg Thr Glu Glu Arg Pro Ser Gly Ser Arg Leu Gly 
65                  70                  75                  80  


Asp Arg Gly Arg Gly Arg Ala Leu Pro Gly Gly Arg Leu Gly Gly Arg 
                85                  90                  95      


Gly Arg Gly Arg Ala Pro Glu Arg Val Gly Gly Arg Gly Arg Gly Arg 
            100                 105                 110         


Gly Thr Ala Ala Pro Arg Ala Ala Pro Ala Ala Arg Gly Ser Arg Pro 
        115                 120                 125             


Gly Pro Ala Gly Thr Met Ala Ala Gly Ser Ile Thr Thr Leu Pro Ala 
    130                 135                 140                 


Leu Pro Glu Asp Gly Gly Ser Gly Ala Phe Pro Pro Gly His Phe Lys 
145                 150                 155                 160 


Asp Pro Lys Arg Leu Tyr Cys Lys Asn Gly Gly Phe Phe Leu Arg Ile 
                165                 170                 175     


His Pro Asp Gly Arg Val Asp Gly Val Arg Glu Lys Ser Asp Pro His 
            180                 185                 190         


Ile Lys Leu Gln Leu Gln Ala Glu Glu Arg Gly Val Val Ser Ile Lys 
        195                 200                 205             


Gly Val Cys Ala Asn Arg Tyr Leu Ala Met Lys Glu Asp Gly Arg Leu 
    210                 215                 220                 


Leu Ala Ser Lys Cys Val Thr Asp Glu Cys Phe Phe Phe Glu Arg Leu 
225                 230                 235                 240 


Glu Ser Asn Asn Tyr Asn Thr Tyr Arg Ser Arg Lys Tyr Thr Ser Trp 
                245                 250                 255     


Tyr Val Ala Leu Lys Arg Thr Gly Gln Tyr Lys Leu Gly Ser Lys Thr 
            260                 265                 270         


Gly Pro Gly Gln Lys Ala Ile Leu Phe Leu Pro Met Ser Ala Lys Ser 
        275                 280                 285             


<210>  15
<211>  351
<212>  PRT
<213>  Vaccinia virus

<400>  15

Met Thr Met Lys Met Met Val His Ile Tyr Phe Val Ser Leu Leu Leu 
1               5                   10                  15      


Leu Leu Phe His Ser Tyr Ala Ile Asp Ile Glu Asn Glu Ile Thr Glu 
            20                  25                  30          


Phe Phe Asn Lys Met Arg Asp Thr Leu Pro Ala Lys Asp Ser Lys Trp 
        35                  40                  45              


Leu Asn Pro Ala Cys Met Phe Gly Gly Thr Met Asn Asp Ile Ala Ala 
    50                  55                  60                  


Leu Gly Glu Pro Phe Ser Ala Lys Cys Pro Pro Ile Glu Asp Ser Leu 
65                  70                  75                  80  


Leu Ser His Arg Tyr Lys Asp Tyr Val Val Lys Trp Glu Arg Leu Glu 
                85                  90                  95      


Lys Asn Arg Arg Arg Gln Val Ser Asn Lys Arg Val Lys His Gly Asp 
            100                 105                 110         


Leu Trp Ile Ala Asn Tyr Thr Ser Lys Phe Ser Asn Arg Arg Tyr Leu 
        115                 120                 125             


Cys Thr Val Thr Thr Lys Asn Gly Asp Cys Val Gln Gly Ile Val Arg 
    130                 135                 140                 


Ser His Ile Arg Lys Pro Pro Ser Cys Ile Pro Lys Thr Tyr Glu Leu 
145                 150                 155                 160 


Gly Thr His Asp Lys Tyr Gly Ile Asp Leu Tyr Cys Gly Ile Leu Tyr 
                165                 170                 175     


Ala Lys His Tyr Asn Asn Ile Thr Trp Tyr Lys Asp Asn Lys Glu Ile 
            180                 185                 190         


Asn Ile Asp Asp Ile Lys Tyr Ser Gln Thr Gly Lys Glu Leu Ile Ile 
        195                 200                 205             


His Asn Pro Glu Leu Glu Asp Ser Gly Arg Tyr Asp Cys Tyr Val His 
    210                 215                 220                 


Tyr Asp Asp Val Arg Ile Lys Asn Asp Ile Val Val Ser Arg Cys Lys 
225                 230                 235                 240 


Ile Leu Thr Val Ile Pro Ser Gln Asp His Arg Phe Lys Leu Ile Leu 
                245                 250                 255     


Asp Pro Lys Ile Asn Val Thr Ile Gly Glu Pro Ala Asn Ile Thr Cys 
            260                 265                 270         


Thr Ala Val Ser Thr Ser Leu Leu Ile Asp Asp Val Leu Ile Glu Trp 
        275                 280                 285             


Glu Asn Pro Ser Gly Trp Leu Ile Gly Phe Asp Phe Asp Val Tyr Ser 
    290                 295                 300                 


Val Leu Thr Ser Arg Gly Gly Ile Thr Glu Ala Thr Leu Tyr Phe Glu 
305                 310                 315                 320 


Asn Val Thr Glu Glu Tyr Ile Gly Asn Thr Tyr Lys Cys Arg Gly His 
                325                 330                 335     


Asn Tyr Tyr Phe Glu Lys Thr Leu Thr Thr Thr Val Val Leu Glu 
            340                 345                 350     


<210>  16
<211>  353
<212>  PRT
<213>  Vaccinia virus

<400>  16

Met Thr Met Lys Met Met Val His Ile Tyr Phe Val Ser Leu Ser Leu 
1               5                   10                  15      


Leu Leu Leu Leu Phe His Ser Tyr Ala Ile Asp Ile Glu Asn Glu Ile 
            20                  25                  30          


Thr Glu Phe Phe Asn Lys Met Arg Asp Thr Leu Pro Ala Lys Asp Ser 
        35                  40                  45              


Lys Trp Leu Asn Pro Ala Cys Met Phe Gly Gly Thr Met Asn Asp Met 
    50                  55                  60                  


Ala Thr Leu Gly Glu Pro Phe Ser Ala Lys Cys Pro Pro Ile Glu Asp 
65                  70                  75                  80  


Ser Leu Leu Ser His Arg Tyr Lys Asp Tyr Val Val Lys Trp Glu Arg 
                85                  90                  95      


Leu Glu Lys Asn Arg Arg Arg Gln Val Ser Asn Lys Arg Val Lys His 
            100                 105                 110         


Gly Asp Leu Trp Ile Ala Asn Tyr Thr Ser Lys Phe Ser Asn Arg Arg 
        115                 120                 125             


Tyr Leu Cys Thr Val Thr Thr Lys Asn Gly Asp Cys Val Gln Gly Ile 
    130                 135                 140                 


Val Arg Ser His Ile Lys Lys Pro Pro Ser Cys Ile Pro Lys Thr Tyr 
145                 150                 155                 160 


Glu Leu Gly Thr His Asp Lys Tyr Gly Ile Asp Leu Tyr Cys Gly Ile 
                165                 170                 175     


Leu Tyr Ala Lys His Tyr Asn Asn Ile Thr Trp Tyr Lys Asp Asn Lys 
            180                 185                 190         


Glu Ile Asn Ile Asp Asp Ile Lys Tyr Ser Gln Thr Gly Lys Glu Leu 
        195                 200                 205             


Ile Ile His Asn Pro Glu Leu Glu Asp Ser Gly Arg Tyr Asp Cys Tyr 
    210                 215                 220                 


Val His Tyr Asp Asp Val Arg Ile Lys Asn Asp Ile Val Val Ser Arg 
225                 230                 235                 240 


Cys Lys Ile Leu Thr Val Ile Pro Ser Gln Asp His Arg Phe Lys Leu 
                245                 250                 255     


Ile Leu Asp Pro Lys Ile Asn Val Thr Ile Gly Glu Pro Ala Asn Ile 
            260                 265                 270         


Thr Cys Thr Ala Val Ser Thr Ser Leu Leu Ile Asp Asp Val Leu Ile 
        275                 280                 285             


Glu Trp Glu Asn Pro Ser Gly Trp Leu Ile Gly Phe Asp Phe Asp Val 
    290                 295                 300                 


Tyr Ser Val Leu Thr Ser Arg Gly Gly Ile Thr Glu Ala Thr Leu Tyr 
305                 310                 315                 320 


Phe Glu Asn Val Thr Glu Glu Tyr Ile Gly Asn Thr Tyr Lys Cys Arg 
                325                 330                 335     


Gly His Asn Tyr Tyr Phe Glu Lys Thr Leu Thr Thr Thr Val Val Leu 
            340                 345                 350         


Glu 
    


<210>  17
<211>  265
<212>  PRT
<213>  Vaccinia virus

<400>  17

Met Thr Met Lys Met Met Val His Ile Tyr Phe Val Ser Leu Ser Leu 
1               5                   10                  15      


Leu Leu Leu Leu Phe His Ser Tyr Ala Ile Asp Ile Glu Asn Glu Ile 
            20                  25                  30          


Thr Glu Phe Phe Asn Lys Met Arg Asp Thr Leu Pro Ala Lys Asp Ser 
        35                  40                  45              


Lys Trp Leu Asn Pro Ala Cys Met Phe Gly Gly Thr Met Asn Asp Met 
    50                  55                  60                  


Ala Thr Leu Gly Glu Pro Phe Ser Ala Lys Cys Pro Pro Ile Glu Asp 
65                  70                  75                  80  


Ser Leu Leu Ser His Arg Tyr Lys Asp Tyr Val Val Lys Trp Glu Arg 
                85                  90                  95      


Leu Glu Lys Asn Arg Arg Arg Gln Val Ser Asn Lys Arg Val Lys His 
            100                 105                 110         


Gly Asp Leu Trp Ile Ala Asn Tyr Thr Ser Lys Phe Ser Asn Arg Arg 
        115                 120                 125             


Tyr Leu Cys Thr Val Thr Thr Lys Asn Gly Asp Cys Val Gln Gly Ile 
    130                 135                 140                 


Val Arg Ser His Ile Arg Lys Pro Pro Ser Cys Ile Pro Lys Thr Tyr 
145                 150                 155                 160 


Glu Leu Gly Thr His Asp Lys Tyr Gly Ile Asp Leu Tyr Cys Gly Ile 
                165                 170                 175     


Leu Tyr Ala Lys His Tyr Asn Asn Ile Thr Trp Tyr Lys Asp Asn Lys 
            180                 185                 190         


Glu Ile Asn Ile Asp Asp Ile Lys Tyr Ser Gln Thr Gly Lys Lys Leu 
        195                 200                 205             


Ile Ile His Asn Pro Glu Leu Glu Asp Ser Gly Arg Tyr Asp Cys Tyr 
    210                 215                 220                 


Val His Tyr Asp Asp Val Arg Ile Lys Asn Asp Ile Val Val Ser Arg 
225                 230                 235                 240 


Cys Lys Ile Leu Thr Val Ile Pro Ser Gln Asp His Arg Phe Lys Leu 
                245                 250                 255     


Lys Arg Asn Cys Gly Tyr Ala Ser Asn 
            260                 265 



<210>  18
<211>  1056
<212>  DNA
<213>  Vaccinia virus

<400>  18
atgacgatga aaatgatggt acatatatat ttcgtatcat tattgttatt gctattccac       60

agttacgcca tagacatcga aaatgaaatc acagaattct tcaataaaat gagagatact      120

ctaccagcta aagactctaa atggttgaat ccagcatgta tgttcggagg cacaatgaat      180

gatatagccg ctctaggaga gccattcagc gcaaagtgtc ctcctattga agacagtctt      240

ttatcgcaca gatataaaga ctatgtggtt aaatgggaaa ggctagaaaa aaatagacgg      300

cgacaggttt ctaataaacg tgttaaacat ggtgatttat ggatagccaa ctatacatct      360

aaattcagta accgtaggta tttgtgcacc gtaactacaa agaatggtga ctgtgttcag      420

ggtatagtta gatctcatat tagaaaacct ccttcatgca ttccaaaaac atatgaacta      480

ggtactcatg ataagtatgg catagactta tactgtggaa ttctttacgc aaaacattat      540

aataatataa cttggtataa agataataag gaaattaata tcgacgacat taagtattca      600

caaacgggaa aggaattaat tattcataat ccagagttag aagatagcgg aagatacgac      660

tgttacgttc attacgacga cgttagaatc aagaatgata tcgtagtatc aagatgtaaa      720

atacttacgg ttataccgtc acaagaccac aggtttaaac taatactaga tccaaaaatc      780

aacgtaacga taggagaacc tgccaatata acatgcactg ctgtgtcaac gtcattattg      840

attgacgatg tactgattga atgggaaaat ccatccggat ggcttatagg attcgatttt      900

gatgtatact ctgttttaac tagtagaggc ggtattaccg aggcgacctt gtactttgaa      960

aatgttactg aagaatatat aggtaataca tataaatgtc gtggacacaa ctattatttt     1020

gaaaaaaccc ttacaactac agtagtattg gagtaa                               1056



<210>  19
<211>  1062
<212>  DNA
<213>  Vaccinia virus

<400>  19
atgacgatga aaatgatggt acatatatat ttcgtatcat tatcattatt gttattgcta       60

ttccacagtt acgccataga catcgaaaat gaaatcacag aattcttcaa taaaatgaga      120

gatactctac cagctaaaga ctctaaatgg ttgaatccag catgtatgtt cggaggcaca      180

atgaatgata tggccactct aggagagcca ttcagtgcaa agtgtcctcc tattgaagac      240

agtcttttat cgcacagata taaagactat gtggttaaat gggagaggct agaaaagaat      300

agacggcgac aggtttctaa taaacgtgtt aaacatggtg atttatggat agccaactat      360

acatctaaat tcagtaaccg taggtatttg tgcaccgtaa ctacaaagaa tggtgactgt      420

gttcagggta tagttagatc tcatattaaa aaacctcctt catgcattcc aaaaacatat      480

gaactaggta ctcatgataa gtatggcata gacttatact gtggaattct ttacgcaaaa      540

cattataata atataacttg gtataaagat aataaggaaa ttaatatcga cgacattaag      600

tattcacaaa cgggaaagga attaattatt cataatccag agttagaaga tagcggaaga      660

tacgactgtt acgttcatta cgacgacgtt agaatcaaga atgatatcgt agtatcaaga      720

tgtaaaatac ttacggttat accgtcacaa gaccacaggt ttaaactaat actagatccg      780

aaaatcaacg taacgatagg agaacctgcc aatataacat gcactgctgt gtcaacgtca      840

ttattgattg acgatgtact gattgaatgg gaaaatccat ccggatggct tataggattc      900

gattttgatg tatactctgt tttaactagt agaggcggta tcaccgaggc gaccttgtac      960

tttgaaaatg ttactgaaga atatataggt aatacatata aatgtcgtgg acacaactat     1020

tattttgaaa aaacccttac aactacagta gtattggagt aa                        1062


<210>  20
<211>  798
<212>  DNA
<213>  Vaccinia virus

<400>  20
atgacgatga aaatgatggt acatatatat ttcgtatcat tatcattatt gttattgcta       60

ttccacagtt acgccataga catcgaaaat gaaatcacag aattcttcaa taaaatgaga      120

gatactctac cagctaaaga ctctaaatgg ttgaatccag catgtatgtt cggaggcaca      180

atgaatgata tagccgctct aggagagcca ttcagcgcaa agtgtcctcc tattgaagac      240

agtcttttat cgcacagata taaagactat gtggttaaat gggaaaggct agaaaagaat      300

agacggcgac aggtttctaa taaacgtgtt aaacatggtg atttatggat agccaactat      360

acatctaaat tcagtaaccg taggtatttg tgcaccgtaa ctacaaagaa tggtgactgt      420

gttcagggta tagttagatc tcatattaga aaacctcctt catgcattcc aaaaacatat      480

gaactaggta ctcatgataa gtatggcata gacttatact gtggaattct ttacgcaaaa      540

cattataata atataacttg gtataaagat aataaggaaa ttaatatcga cgatattaag      600

tattcacaaa cgggaaagaa attaattatt cataatccag agttagaaga tagcggaaga      660

tacgactgtt acgttcatta cgacgacgtt agaatcaaga atgatatcgt agtatcaaga      720

tgtaaaatac ttacggtttt accgtcacaa gaccacaggt ttaaactaaa aagaaattgc      780

ggatatgcgt caaattaa                                                    798





