                         SEQUENCE LISTING

<110>  THE ROYAL INSTITUTION FOR THE ADVANCEMENT OF 
       LEARNING/MCGILL UNIVERSITY
 
<120>  THERAPEUTICS FOR THE INDUCTION OF ENDOGENOUS STEROIDOGENESIS AND 
       METHODS ASSOCIATED WITH THEIR IDENTIFICATION

<130>  05001770-503PCT

<150>  61/834,993
<151>  2013-06-14

<150>  61/953,336
<151>  2014-03-14

<160>  30    

<170>  PatentIn version 3.5

<210>  1
<211>  7
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  14-3-3 binding motif mode I


<220>
<221>  VARIANT
<222>  (3)..(3)
<223>  Xaa can be any amino acid

<220>
<221>  VARIANT
<222>  (6)..(6)
<223>  Xaa can be any amino acid

<400>  1

Arg Ser Xaa Pro Ser Xaa Pro 
1               5           


<210>  2
<211>  8
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  14-3-3 binding motif mode II


<220>
<221>  VARIANT
<222>  (2)..(2)
<223>  Xaa can be any amino acid

<220>
<221>  VARIANT
<222>  (3)..(3)
<223>  Xaa can be any amino acid

<220>
<221>  VARIANT
<222>  (4)..(4)
<223>  Xaa can be any amino acid

<220>
<221>  VARIANT
<222>  (7)..(7)
<223>  Xaa can be any amino acid

<400>  2

Arg Xaa Xaa Xaa Pro Ser Xaa Pro 
1               5               


<210>  3
<211>  5
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  14-3-3 binding motif mode III


<220>
<221>  VARIANT
<222>  (2)..(2)
<223>  Xaa can be Ser or Pro

<220>
<221>  VARIANT
<222>  (4)..(4)
<223>  Xaa can be any amino acid except Pro

<220>
<221>  VARIANT
<222>  (5)..(5)
<223>  Xaa can be any amino acid except Pro

<400>  3

Pro Xaa Thr Xaa Xaa 
1               5   


<210>  4
<211>  6
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  14-3-3 motif of mVDAC1

<400>  4

Lys Thr Lys Ser Glu Asn 
1               5       


<210>  5
<211>  7
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  14-3-3 motif of mVDAC1

<400>  5

Arg Val Thr Gln Ser Asn Phe 
1               5           


<210>  6
<211>  25
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  TVS35 peptide

<400>  6

Tyr Gly Arg Lys Lys Arg Arg Gln Arg Arg Arg Gly Lys Leu Asp Leu 
1               5                   10                  15      


Lys Thr Lys Ser Glu Asn Gly Leu Glu 
            20                  25  


<210>  7
<211>  25
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  TVS167 peptide

<400>  7

Tyr Gly Arg Lys Lys Arg Arg Gln Arg Arg Arg Gly Ser Lys Ser Arg 
1               5                   10                  15      


Val Thr Gln Ser Asn Phe Ala Val Gly 
            20                  25  


<210>  8
<211>  25
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  TVG35 peptide

<400>  8

Tyr Gly Arg Lys Lys Arg Arg Gln Arg Arg Arg Gly Lys Leu Asp Leu 
1               5                   10                  15      


Lys Thr Lys Gly Glu Asn Gly Leu Glu 
            20                  25  


<210>  9
<211>  25
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  TVG167 peptide

<400>  9

Tyr Gly Arg Lys Lys Arg Arg Gln Arg Arg Arg Gly Ser Lys Ser Arg 
1               5                   10                  15      


Val Thr Gln Gly Asn Phe Ala Val Gly 
            20                  25  


<210>  10
<211>  7
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  14-3-3 motif

<400>  10

Arg Arg Arg Ser Ser Leu Leu 
1               5           


<210>  11
<211>  7
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  14-3-3 motif

<400>  11

Arg Asp Phe Val Ser Val Arg 
1               5           


<210>  12
<211>  6
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  14-3-3 motif

<400>  12

Arg Arg Gly Ser Thr Cys 
1               5       


<210>  13
<211>  6
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  14-3-3 motif

<400>  13

Lys Thr Lys Ser Glu Asn 
1               5       


<210>  14
<211>  7
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  14-3-3 motif

<400>  14

Arg Val Thr Gln Ser Asn Phe 
1               5           


<210>  15
<211>  7
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  14-3-3 motif

<400>  15

Arg Trp Tyr Ala Ser Leu Gln 
1               5           


<210>  16
<211>  7
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  14-3-3 motif

<400>  16

Arg Gly Gly Ser Arg Leu Pro 
1               5           


<210>  17
<211>  255
<212>  PRT
<213>  Mus musculus

<400>  17

Met Asp Asp Arg Glu Asp Leu Val Tyr Gln Ala Lys Leu Ala Glu Gln 
1               5                   10                  15      


Ala Glu Arg Tyr Asp Glu Met Val Glu Ser Met Lys Lys Val Ala Gly 
            20                  25                  30          


Met Asp Val Glu Leu Thr Val Glu Glu Arg Asn Leu Leu Ser Val Ala 
        35                  40                  45              


Tyr Lys Asn Val Ile Gly Ala Arg Arg Ala Ser Trp Arg Ile Ile Ser 
    50                  55                  60                  


Ser Ile Glu Gln Lys Glu Glu Asn Lys Gly Gly Glu Asp Lys Leu Lys 
65                  70                  75                  80  


Met Ile Arg Glu Tyr Arg Gln Met Val Glu Thr Glu Leu Lys Leu Ile 
                85                  90                  95      


Cys Cys Asp Ile Leu Asp Val Leu Asp Lys His Leu Ile Pro Ala Ala 
            100                 105                 110         


Asn Thr Gly Glu Ser Lys Val Phe Tyr Tyr Lys Met Lys Gly Asp Tyr 
        115                 120                 125             


His Arg Tyr Leu Ala Glu Phe Ala Thr Gly Asn Asp Arg Lys Glu Ala 
    130                 135                 140                 


Ala Glu Asn Ser Leu Val Ala Tyr Lys Ala Ala Ser Asp Ile Ala Met 
145                 150                 155                 160 


Thr Glu Leu Pro Pro Thr His Pro Ile Arg Leu Gly Leu Ala Leu Asn 
                165                 170                 175     


Phe Ser Val Phe Tyr Tyr Glu Ile Leu Asn Ser Pro Asp Arg Ala Cys 
            180                 185                 190         


Arg Leu Ala Lys Ala Ala Phe Asp Asp Ala Ile Ala Glu Leu Asp Thr 
        195                 200                 205             


Leu Ser Glu Glu Ser Tyr Lys Asp Ser Thr Leu Ile Met Gln Leu Leu 
    210                 215                 220                 


Arg Asp Asn Leu Thr Leu Trp Thr Ser Asp Met Gln Gly Asp Gly Glu 
225                 230                 235                 240 


Glu Gln Asn Lys Glu Ala Leu Gln Asp Val Glu Asp Glu Asn Gln 
                245                 250                 255 


<210>  18
<211>  255
<212>  PRT
<213>  Homo sapiens

<400>  18

Met Asp Asp Arg Glu Asp Leu Val Tyr Gln Ala Lys Leu Ala Glu Gln 
1               5                   10                  15      


Ala Glu Arg Tyr Asp Glu Met Val Glu Ser Met Lys Lys Val Ala Gly 
            20                  25                  30          


Met Asp Val Glu Leu Thr Val Glu Glu Arg Asn Leu Leu Ser Val Ala 
        35                  40                  45              


Tyr Lys Asn Val Ile Gly Ala Arg Arg Ala Ser Trp Arg Ile Ile Ser 
    50                  55                  60                  


Ser Ile Glu Gln Lys Glu Glu Asn Lys Gly Gly Glu Asp Lys Leu Lys 
65                  70                  75                  80  


Met Ile Arg Glu Tyr Arg Gln Met Val Glu Thr Glu Leu Lys Leu Ile 
                85                  90                  95      


Cys Cys Asp Ile Leu Asp Val Leu Asp Lys His Leu Ile Pro Ala Ala 
            100                 105                 110         


Asn Thr Gly Glu Ser Lys Val Phe Tyr Tyr Lys Met Lys Gly Asp Tyr 
        115                 120                 125             


His Arg Tyr Leu Ala Glu Phe Ala Thr Gly Asn Asp Arg Lys Glu Ala 
    130                 135                 140                 


Ala Glu Asn Ser Leu Val Ala Tyr Lys Ala Ala Ser Asp Ile Ala Met 
145                 150                 155                 160 


Thr Glu Leu Pro Pro Thr His Pro Ile Arg Leu Gly Leu Ala Leu Asn 
                165                 170                 175     


Phe Ser Val Phe Tyr Tyr Glu Ile Leu Asn Ser Pro Asp Arg Ala Cys 
            180                 185                 190         


Arg Leu Ala Lys Ala Ala Phe Asp Asp Ala Ile Ala Glu Leu Asp Thr 
        195                 200                 205             


Leu Ser Glu Glu Ser Tyr Lys Asp Ser Thr Leu Ile Met Gln Leu Leu 
    210                 215                 220                 


Arg Asp Asn Leu Thr Leu Trp Thr Ser Asp Met Gln Gly Asp Gly Glu 
225                 230                 235                 240 


Glu Gln Asn Lys Glu Ala Leu Gln Asp Val Glu Asp Glu Asn Gln 
                245                 250                 255 


<210>  19
<211>  255
<212>  PRT
<213>  Rattus norvegicus

<400>  19

Met Asp Asp Arg Glu Asp Leu Val Tyr Gln Ala Lys Leu Ala Glu Gln 
1               5                   10                  15      


Ala Glu Arg Tyr Asp Glu Met Val Glu Ser Met Lys Lys Val Ala Gly 
            20                  25                  30          


Met Asp Val Glu Leu Thr Val Glu Glu Arg Asn Leu Leu Ser Val Ala 
        35                  40                  45              


Tyr Lys Asn Val Ile Gly Ala Arg Arg Ala Ser Trp Arg Ile Ile Ser 
    50                  55                  60                  


Ser Ile Glu Gln Lys Glu Glu Asn Lys Gly Gly Glu Asp Lys Leu Lys 
65                  70                  75                  80  


Met Ile Arg Glu Tyr Arg Gln Met Val Glu Thr Glu Leu Lys Leu Ile 
                85                  90                  95      


Cys Cys Asp Ile Leu Asp Val Leu Asp Lys His Leu Ile Pro Ala Ala 
            100                 105                 110         


Asn Thr Gly Glu Ser Lys Val Phe Tyr Tyr Lys Met Lys Gly Asp Tyr 
        115                 120                 125             


His Arg Tyr Leu Ala Glu Phe Ala Thr Gly Asn Asp Arg Lys Glu Ala 
    130                 135                 140                 


Ala Glu Asn Ser Leu Val Ala Tyr Lys Ala Ala Ser Asp Ile Ala Met 
145                 150                 155                 160 


Thr Glu Leu Pro Pro Thr His Pro Ile Arg Leu Gly Leu Ala Leu Asn 
                165                 170                 175     


Phe Ser Val Phe Tyr Tyr Glu Ile Leu Asn Ser Pro Asp Arg Ala Cys 
            180                 185                 190         


Arg Leu Ala Lys Ala Ala Phe Asp Asp Ala Ile Ala Glu Leu Asp Thr 
        195                 200                 205             


Leu Ser Glu Glu Ser Tyr Lys Asp Ser Thr Leu Ile Met Gln Leu Leu 
    210                 215                 220                 


Arg Asp Asn Leu Thr Leu Trp Thr Ser Asp Met Gln Gly Asp Gly Glu 
225                 230                 235                 240 


Glu Gln Asn Lys Glu Ala Leu Gln Asp Val Glu Asp Glu Asn Gln 
                245                 250                 255 


<210>  20
<211>  283
<212>  PRT
<213>  Mus musculus

<400>  20

Met Ala Val Pro Pro Thr Tyr Ala Asp Leu Gly Lys Ser Ala Arg Asp 
1               5                   10                  15      


Val Phe Thr Lys Gly Tyr Gly Phe Gly Leu Ile Lys Leu Asp Leu Lys 
            20                  25                  30          


Thr Lys Ser Glu Asn Gly Leu Glu Phe Thr Ser Ser Gly Ser Ala Asn 
        35                  40                  45              


Thr Glu Thr Thr Lys Val Asn Gly Ser Leu Glu Thr Lys Tyr Arg Trp 
    50                  55                  60                  


Thr Glu Tyr Gly Leu Thr Phe Thr Glu Lys Trp Asn Thr Asp Asn Thr 
65                  70                  75                  80  


Leu Gly Thr Glu Ile Thr Val Glu Asp Gln Leu Ala Arg Gly Leu Lys 
                85                  90                  95      


Leu Thr Phe Asp Ser Ser Phe Ser Pro Asn Thr Gly Lys Lys Asn Ala 
            100                 105                 110         


Lys Ile Lys Thr Gly Tyr Lys Arg Glu His Ile Asn Leu Gly Cys Asp 
        115                 120                 125             


Val Asp Phe Asp Ile Ala Gly Pro Ser Ile Arg Gly Ala Leu Val Leu 
    130                 135                 140                 


Gly Tyr Glu Gly Trp Leu Ala Gly Tyr Gln Met Asn Phe Glu Thr Ser 
145                 150                 155                 160 


Lys Ser Arg Val Thr Gln Ser Asn Phe Ala Val Gly Tyr Lys Thr Asp 
                165                 170                 175     


Glu Phe Gln Leu His Thr Asn Val Asn Asp Gly Thr Glu Phe Gly Gly 
            180                 185                 190         


Ser Ile Tyr Gln Lys Val Asn Lys Lys Leu Glu Thr Ala Val Asn Leu 
        195                 200                 205             


Ala Trp Thr Ala Gly Asn Ser Asn Thr Arg Phe Gly Ile Ala Ala Lys 
    210                 215                 220                 


Tyr Gln Val Asp Pro Asp Ala Cys Phe Ser Ala Lys Val Asn Asn Ser 
225                 230                 235                 240 


Ser Leu Ile Gly Leu Gly Tyr Thr Gln Thr Leu Lys Pro Gly Ile Lys 
                245                 250                 255     


Leu Thr Leu Ser Ala Leu Leu Asp Gly Lys Asn Val Asn Ala Gly Gly 
            260                 265                 270         


His Lys Leu Gly Leu Gly Leu Glu Phe Gln Ala 
        275                 280             


<210>  21
<211>  283
<212>  PRT
<213>  Homo sapiens

<400>  21

Met Ala Val Pro Pro Thr Tyr Ala Asp Leu Gly Lys Ser Ala Arg Asp 
1               5                   10                  15      


Val Phe Thr Lys Gly Tyr Gly Phe Gly Leu Ile Lys Leu Asp Leu Lys 
            20                  25                  30          


Thr Lys Ser Glu Asn Gly Leu Glu Phe Thr Ser Ser Gly Ser Ala Asn 
        35                  40                  45              


Thr Glu Thr Thr Lys Val Thr Gly Ser Leu Glu Thr Lys Tyr Arg Trp 
    50                  55                  60                  


Thr Glu Tyr Gly Leu Thr Phe Thr Glu Lys Trp Asn Thr Asp Asn Thr 
65                  70                  75                  80  


Leu Gly Thr Glu Ile Thr Val Glu Asp Gln Leu Ala Arg Gly Leu Lys 
                85                  90                  95      


Leu Thr Phe Asp Ser Ser Phe Ser Pro Asn Thr Gly Lys Lys Asn Ala 
            100                 105                 110         


Lys Ile Lys Thr Gly Tyr Lys Arg Glu His Ile Asn Leu Gly Cys Asp 
        115                 120                 125             


Met Asp Phe Asp Ile Ala Gly Pro Ser Ile Arg Gly Ala Leu Val Leu 
    130                 135                 140                 


Gly Tyr Glu Gly Trp Leu Ala Gly Tyr Gln Met Asn Phe Glu Thr Ala 
145                 150                 155                 160 


Lys Ser Arg Val Thr Gln Ser Asn Phe Ala Val Gly Tyr Lys Thr Asp 
                165                 170                 175     


Glu Phe Gln Leu His Thr Asn Val Asn Asp Gly Thr Glu Phe Gly Gly 
            180                 185                 190         


Ser Ile Tyr Gln Lys Val Asn Lys Lys Leu Glu Thr Ala Val Asn Leu 
        195                 200                 205             


Ala Trp Thr Ala Gly Asn Ser Asn Thr Arg Phe Gly Ile Ala Ala Lys 
    210                 215                 220                 


Tyr Gln Ile Asp Pro Asp Ala Cys Phe Ser Ala Lys Val Asn Asn Ser 
225                 230                 235                 240 


Ser Leu Ile Gly Leu Gly Tyr Thr Gln Thr Leu Lys Pro Gly Ile Lys 
                245                 250                 255     


Leu Thr Leu Ser Ala Leu Leu Asp Gly Lys Asn Val Asn Ala Gly Gly 
            260                 265                 270         


His Lys Leu Gly Leu Gly Leu Glu Phe Gln Ala 
        275                 280             


<210>  22
<211>  283
<212>  PRT
<213>  Rattus norvegicus

<400>  22

Met Ala Val Pro Pro Thr Tyr Ala Asp Leu Gly Lys Ser Ala Arg Asp 
1               5                   10                  15      


Val Phe Thr Lys Gly Tyr Gly Phe Gly Leu Ile Lys Leu Asp Leu Lys 
            20                  25                  30          


Thr Lys Ser Glu Asn Gly Leu Glu Phe Thr Ser Ser Gly Ser Ala Asn 
        35                  40                  45              


Thr Glu Thr Thr Lys Val Asn Gly Ser Leu Glu Thr Lys Tyr Arg Trp 
    50                  55                  60                  


Thr Glu Tyr Gly Leu Thr Phe Thr Glu Lys Trp Asn Thr Asp Asn Thr 
65                  70                  75                  80  


Leu Gly Thr Glu Ile Thr Val Glu Asp Gln Leu Ala Arg Gly Leu Lys 
                85                  90                  95      


Leu Thr Phe Asp Ser Ser Phe Ser Pro Asn Thr Gly Lys Lys Asn Ala 
            100                 105                 110         


Lys Ile Lys Thr Gly Tyr Lys Arg Glu His Ile Asn Leu Gly Cys Asp 
        115                 120                 125             


Val Asp Phe Asp Ile Ala Gly Pro Ser Ile Arg Gly Ala Leu Val Leu 
    130                 135                 140                 


Gly Tyr Glu Gly Trp Leu Ala Gly Tyr Gln Met Asn Phe Glu Thr Ser 
145                 150                 155                 160 


Lys Ser Arg Val Thr Gln Ser Asn Phe Ala Val Gly Tyr Lys Thr Asp 
                165                 170                 175     


Glu Phe Gln Leu His Thr Asn Val Asn Asp Gly Thr Glu Phe Gly Gly 
            180                 185                 190         


Ser Ile Tyr Gln Lys Val Asn Lys Lys Leu Glu Thr Ala Val Asn Leu 
        195                 200                 205             


Ala Trp Thr Ala Gly Asn Ser Asn Thr Arg Phe Gly Ile Ala Ala Lys 
    210                 215                 220                 


Tyr Gln Val Asp Pro Asp Ala Cys Phe Ser Ala Lys Val Asn Asn Ser 
225                 230                 235                 240 


Ser Leu Ile Gly Leu Gly Tyr Thr Gln Thr Leu Lys Pro Gly Ile Lys 
                245                 250                 255     


Leu Thr Leu Ser Ala Leu Leu Asp Gly Lys Asn Val Asn Ala Gly Gly 
            260                 265                 270         


His Lys Leu Gly Leu Gly Leu Glu Phe Gln Ala 
        275                 280             


<210>  23
<211>  18
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Oligonucleotide

<400>  23
gcaagaucau cauuagaa                                                     18


<210>  24
<211>  18
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Oligonucleotide

<400>  24
guaguaaucu uuaccuuu                                                     18


<210>  25
<211>  18
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Oligonucleotide

<400>  25
gggaggagag gacaaauu                                                     18


<210>  26
<211>  18
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Oligonucleotide

<400>  26
cuccuguuua auuucuac                                                     18


<210>  27
<211>  18
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Oligonucleotide

<400>  27
agaugagaau cagugaga                                                     18


<210>  28
<211>  18
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Oligonucleotide

<400>  28
uuagucacuc ugcuuuau                                                     18


<210>  29
<211>  11
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  TAT peptide

<400>  29

Tyr Gly Arg Lys Lys Arg Arg Gln Arg Arg Arg 
1               5                   10      


<210>  30
<211>  13
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  14-3-3 binding motif

<400>  30

Ser Lys Ser Arg Val Thr Gln Ser Asn Phe Ala Val Gly 
1               5                   10              


