                         SEQUENCE LISTING

<110>  AM Chemicals LLC
       Guzaev, Andrei P.
       Vvedenskiy, Yladimir Y.
 
<120>  Phosphoramidite Building Blocks for Sugar-Conjugated 
       Oligonucleotides

<130>  95111-910083

<150>  US 61/831,521
<151>  2013-06-05

<160>  15    

<170>  PatentIn version 3.5

<210>  1
<211>  10
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic polynucleotide

<400>  1
tttttttttt                                                              10


<210>  2
<211>  10
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic polynucleotide


<220>
<221>  modified_base
<222>  (1)..(1)
<223>  Residue modified to 
       thymidine-3'-[[(beta-D-glucopyranosyl)oxy]propyl]phosphate

<400>  2
tttttttttt                                                              10


<210>  3
<211>  10
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic polynucleotide


<220>
<221>  modified_base
<222>  (1)..(1)
<223>  Residue modified to 
       thymidine-3'-[[(beta-D-glucopyranosyl)oxy]propyl]phosphate

<220>
<221>  modified_base
<222>  (2)..(2)
<223>  Residue modified to 
       thymidine-3'-[[(beta-D-glucopyranosyl)oxy]propyl]phosphate

<400>  3
tttttttttt                                                              10


<210>  4
<211>  10
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic polynucleotide


<220>
<221>  modified_base
<222>  (1)..(1)
<223>  Residue modified to 
       thymidine-3'-[[(beta-D-glucopyranosyl)oxy]propyl]phosphate

<220>
<221>  modified_base
<222>  (2)..(2)
<223>  Residue modified to 
       thymidine-3'-[[(beta-D-glucopyranosyl)oxy]propyl]phosphate

<220>
<221>  modified_base
<222>  (3)..(3)
<223>  Residue modified to 
       thymidine-3'-[[(beta-D-glucopyranosyl)oxy]propyl]phosphate

<400>  4
tttttttttt                                                              10


<210>  5
<211>  10
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic polynucleotide


<220>
<221>  modified_base
<222>  (1)..(1)
<223>  Residue modified to 
       thymidine-3'-[[(beta-D-glucopyranosyl)oxy]propyl]phosphate

<220>
<221>  modified_base
<222>  (2)..(2)
<223>  Residue modified to 
       thymidine-3'-[[(beta-D-glucopyranosyl)oxy]propyl]phosphate

<220>
<221>  modified_base
<222>  (3)..(3)
<223>  Residue modified to 
       thymidine-3'-[[(beta-D-glucopyranosyl)oxy]propyl]phosphate

<220>
<221>  modified_base
<222>  (4)..(4)
<223>  Residue modified to 
       thymidine-3'-[[(beta-D-glucopyranosyl)oxy]propyl]phosphate

<400>  5
tttttttttt                                                              10


<210>  6
<211>  10
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic polynucleotide


<220>
<221>  modified_base
<222>  (1)..(1)
<223>  Residue modified at phosphate moiety to phosphotriester with 
       1-[2-[[2-(beta-D-glucopyranosyloxy)ethyl]oxy]ethyl] modification

<220>
<221>  modified_base
<222>  (2)..(2)
<223>  Residue modified at phosphate moiety to phosphotriester with 
       1-[2-[[2-(beta-D-glucopyranosyloxy)ethyl]oxy]ethyl] modification

<220>
<221>  modified_base
<222>  (3)..(3)
<223>  Residue modified at phosphate moiety to phosphotriester with 
       1-[2-[[2-(beta-D-glucopyranosyloxy)ethyl]oxy]ethyl] modification

<220>
<221>  modified_base
<222>  (4)..(4)
<223>  Residue modified at phosphate moiety to phosphotriester with 
       1-[2-[[2-(beta-D-glucopyranosyloxy)ethyl]oxy]ethyl] modification

<400>  6
tttttttttt                                                              10


<210>  7
<211>  10
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic polynucleotide


<220>
<221>  modified_base
<222>  (1)..(1)
<223>  Residue modified at phosphate moiety to phosphotriester with 
       1-[3-(beta-D-glucopyranosyloxy)propyl] modification

<220>
<221>  modified_base
<222>  (2)..(2)
<223>  Residue modified at phosphate moiety to phosphotriester with 
       1-[3-(beta-D-glucopyranosyloxy)propyl] modification

<220>
<221>  modified_base
<222>  (3)..(3)
<223>  Residue modified at phosphate moiety to phosphotriester with 
       1-[3-(beta-D-glucopyranosyloxy)propyl] modification

<220>
<221>  modified_base
<222>  (4)..(4)
<223>  Residue modified at phosphate moiety to phosphotriester with 
       1-[3-(beta-D-glucopyranosyloxy)propyl] modification

<220>
<221>  modified_base
<222>  (6)..(6)
<223>  Residue modified at phosphate moiety to phosphotriester with 
       1-[3-(beta-D-glucopyranosyloxy)propyl] modification

<220>
<221>  modified_base
<222>  (7)..(7)
<223>  Residue modified at phosphate moiety to phosphotriester with 
       1-[3-(beta-D-glucopyranosyloxy)propyl] modification

<220>
<221>  modified_base
<222>  (8)..(8)
<223>  Residue modified at phosphate moiety to phosphotriester with 
       1-[3-(beta-D-glucopyranosyloxy)propyl] modification

<220>
<221>  modified_base
<222>  (9)..(9)
<223>  Residue modified at phosphate moiety to phosphotriester with 
       1-[3-(beta-D-glucopyranosyloxy)propyl] modification

<400>  7
tttttttttt                                                              10


<210>  8
<211>  10
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic polynucleotide


<220>
<221>  modified_base
<222>  (1)..(1)
<223>  Residue modified at phosphate moiety to phosphotriester with 
       1-[3-(beta-D-glucopyranosyloxy)propyl] modification

<220>
<221>  modified_base
<222>  (2)..(2)
<223>  Residue modified at phosphate moiety to phosphotriester with 
       1-[3-(beta-D-glucopyranosyloxy)propyl] modification

<220>
<221>  modified_base
<222>  (3)..(3)
<223>  Residue modified at phosphate moiety to phosphotriester with 
       1-[3-(beta-D-glucopyranosyloxy)propyl] modification

<220>
<221>  modified_base
<222>  (4)..(4)
<223>  Residue modified at phosphate moiety to phosphotriester with 
       1-[3-(beta-D-glucopyranosyloxy)propyl] modification

<220>
<221>  modified_base
<222>  (5)..(5)
<223>  Residue modified at phosphate moiety to phosphotriester with 
       1-[3-(beta-D-glucopyranosyloxy)propyl] modification

<220>
<221>  modified_base
<222>  (6)..(6)
<223>  Residue modified at phosphate moiety to phosphotriester with 
       1-[3-(beta-D-glucopyranosyloxy)propyl] modification

<220>
<221>  modified_base
<222>  (7)..(7)
<223>  Residue modified at phosphate moiety to phosphotriester with 
       1-[3-(beta-D-glucopyranosyloxy)propyl] modification

<220>
<221>  modified_base
<222>  (8)..(8)
<223>  Residue modified at phosphate moiety to phosphotriester with 
       1-[3-(beta-D-glucopyranosyloxy)propyl] modification

<220>
<221>  modified_base
<222>  (9)..(9)
<223>  Residue modified at phosphate moiety to phosphotriester with 
       1-[3-(beta-D-glucopyranosyloxy)propyl] modification

<400>  8
tttttttttt                                                              10


<210>  9
<211>  10
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic polynucleotide


<220>
<221>  modified_base
<222>  (1)..(1)
<223>  Residue modified at phosphate moiety to phosphotriester with 
       1-[2-[[2-(beta-D-glucopyranosyloxy)ethyl]oxy]ethyl] modification

<220>
<221>  modified_base
<222>  (2)..(2)
<223>  Residue modified at phosphate moiety to phosphotriester with 
       1-[2-[[2-(beta-D-glucopyranosyloxy)ethyl]oxy]ethyl] modification

<220>
<221>  modified_base
<222>  (3)..(3)
<223>  Residue modified at phosphate moiety to phosphotriester with 
       1-[2-[[2-(beta-D-glucopyranosyloxy)ethyl]oxy]ethyl] modification

<220>
<221>  modified_base
<222>  (4)..(4)
<223>  Residue modified at phosphate moiety to phosphotriester with 
       1-[2-[[2-(beta-D-glucopyranosyloxy)ethyl]oxy]ethyl] modification

<220>
<221>  modified_base
<222>  (5)..(5)
<223>  Residue modified at phosphate moiety to phosphotriester with 
       1-[2-[[2-(beta-D-glucopyranosyloxy)ethyl]oxy]ethyl] modification

<220>
<221>  modified_base
<222>  (6)..(6)
<223>  Residue modified at phosphate moiety to phosphotriester with 
       1-[2-[[2-(beta-D-glucopyranosyloxy)ethyl]oxy]ethyl] modification

<220>
<221>  modified_base
<222>  (7)..(7)
<223>  Residue modified at phosphate moiety to phosphotriester with 
       1-[2-[[2-(beta-D-glucopyranosyloxy)ethyl]oxy]ethyl] modification

<220>
<221>  modified_base
<222>  (8)..(8)
<223>  Residue modified at phosphate moiety to phosphotriester with 
       1-[2-[[2-(beta-D-glucopyranosyloxy)ethyl]oxy]ethyl] modification

<220>
<221>  modified_base
<222>  (9)..(9)
<223>  Residue modified at phosphate moiety to phosphotriester with 
       1-[2-[[2-(beta-D-glucopyranosyloxy)ethyl]oxy]ethyl] modification

<400>  9
tttttttttt                                                              10


<210>  10
<211>  10
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic polynucleotide


<220>
<221>  modified_base
<222>  (1)..(1)
<223>  Residue modified at phosphate moiety to phosphotriester with 
       1-[2-[[2-(N-acetyl-2-deoxy-2-amino-beta-D-galactopyranosyloxy) 
       ethyl]oxy]ethyl] modification

<220>
<221>  modified_base
<222>  (2)..(2)
<223>  Residue modified at phosphate moiety to phosphotriester with 
       1-[2-[[2-(N-acetyl-2-deoxy-2-amino-beta-D-galactopyranosyloxy) 
       ethyl]oxy]ethyl] modification

<220>
<221>  modified_base
<222>  (3)..(3)
<223>  Residue modified at phosphate moiety to phosphotriester with 
       1-[2-[[2-(N-acetyl-2-deoxy-2-amino-beta-D-galactopyranosyloxy) 
       ethyl]oxy]ethyl] modification

<220>
<221>  modified_base
<222>  (4)..(4)
<223>  Residue modified at phosphate moiety to phosphotriester with 
       1-[2-[[2-(N-acetyl-2-deoxy-2-amino-beta-D-galactopyranosyloxy) 
       ethyl]oxy]ethyl] modification

<400>  10
tttttttttt                                                              10


<210>  11
<211>  10
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic polynucleotide


<220>
<221>  modified_base
<222>  (1)..(1)
<223>  Residue modified at phosphate moiety to phosphotriester with 
       1-[2-[[2-(N-acetyl-2-deoxy-2-amino-beta-D-galactopyranosyloxy) 
       ethyl]oxy]ethyl] modification

<220>
<221>  modified_base
<222>  (2)..(2)
<223>  Residue modified at phosphate moiety to phosphotriester with 
       1-[2-[[2-(N-acetyl-2-deoxy-2-amino-beta-D-galactopyranosyloxy) 
       ethyl]oxy]ethyl] modification

<220>
<221>  modified_base
<222>  (3)..(3)
<223>  Residue modified at phosphate moiety to phosphotriester with 
       1-[2-[[2-(N-acetyl-2-deoxy-2-amino-beta-D-galactopyranosyloxy) 
       ethyl]oxy]ethyl] modification

<220>
<221>  modified_base
<222>  (4)..(4)
<223>  Residue modified at phosphate moiety to phosphotriester with 
       1-[2-[[2-(N-acetyl-2-deoxy-2-amino-beta-D-galactopyranosyloxy) 
       ethyl]oxy]ethyl] modification

<220>
<221>  modified_base
<222>  (6)..(6)
<223>  Residue modified at phosphate moiety to phosphotriester with 
       1-[2-[[2-(N-acetyl-2-deoxy-2-amino-beta-D-galactopyranosyloxy) 
       ethyl]oxy]ethyl] modification

<220>
<221>  modified_base
<222>  (7)..(7)
<223>  Residue modified at phosphate moiety to phosphotriester with 
       1-[2-[[2-(N-acetyl-2-deoxy-2-amino-beta-D-galactopyranosyloxy) 
       ethyl]oxy]ethyl] modification

<220>
<221>  modified_base
<222>  (8)..(8)
<223>  Residue modified at phosphate moiety to phosphotriester with 
       1-[2-[[2-(N-acetyl-2-deoxy-2-amino-beta-D-galactopyranosyloxy) 
       ethyl]oxy]ethyl] modification

<220>
<221>  modified_base
<222>  (9)..(9)
<223>  Residue modified at phosphate moiety to phosphotriester with 
       1-[2-[[2-(N-acetyl-2-deoxy-2-amino-beta-D-galactopyranosyloxy) 
       ethyl]oxy]ethyl] modification

<400>  11
tttttttttt                                                              10


<210>  12
<211>  18
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic polynucleotide


<220>
<221>  modified_base
<222>  (1)..(1)
<223>  Residue modified with phosphorothioate further modified with 
       1-[3-(beta-D-glucopyranosyloxy)propyl] modification

<220>
<221>  modified_base
<222>  (2)..(2)
<223>  Residue modified with phosphorothioate further modified with 
       1-[3-(beta-D-glucopyranosyloxy)propyl] modification

<220>
<221>  modified_base
<222>  (3)..(3)
<223>  Residue modified with phosphorothioate further modified with 
       1-[3-(beta-D-glucopyranosyloxy)propyl] modification

<220>
<221>  modified_base
<222>  (4)..(4)
<223>  Residue modified with phosphorothioate further modified with 
       1-[3-(beta-D-glucopyranosyloxy)propyl] modification

<220>
<221>  modified_base
<222>  (5)..(5)
<223>  Residue modified with phosphorothioate further modified with 
       1-[3-(beta-D-glucopyranosyloxy)propyl] modification

<220>
<221>  modified_base
<222>  (6)..(6)
<223>  Residue modified with phosphorothioate further modified with 
       1-[3-(beta-D-glucopyranosyloxy)propyl] modification

<220>
<221>  modified_base
<222>  (7)..(7)
<223>  Residue modified with phosphorothioate further modified with 
       1-[3-(beta-D-glucopyranosyloxy)propyl] modification

<220>
<221>  modified_base
<222>  (8)..(8)
<223>  Residue modified with phosphorothioate further modified with 
       1-[3-(beta-D-glucopyranosyloxy)propyl] modification

<220>
<221>  modified_base
<222>  (9)..(9)
<223>  Residue modified with phosphorothioate further modified with 
       1-[3-(beta-D-glucopyranosyloxy)propyl] modification

<220>
<221>  modified_base
<222>  (10)..(10)
<223>  Residue modified with phosphorothioate further modified with 
       1-[3-(beta-D-glucopyranosyloxy)propyl] modification

<220>
<221>  modified_base
<222>  (11)..(11)
<223>  Residue modified with phosphorothioate further modified with 
       1-[3-(beta-D-glucopyranosyloxy)propyl] modification

<220>
<221>  modified_base
<222>  (12)..(12)
<223>  Residue modified with phosphorothioate further modified with 
       1-[3-(beta-D-glucopyranosyloxy)propyl] modification

<220>
<221>  modified_base
<222>  (13)..(13)
<223>  Residue modified with phosphorothioate further modified with 
       1-[3-(beta-D-glucopyranosyloxy)propyl] modification

<220>
<221>  modified_base
<222>  (14)..(14)
<223>  Residue modified with phosphorothioate further modified with 
       1-[3-(beta-D-glucopyranosyloxy)propyl] modification

<220>
<221>  modified_base
<222>  (15)..(15)
<223>  Residue modified with phosphorothioate further modified with 
       1-[3-(beta-D-glucopyranosyloxy)propyl] modification

<220>
<221>  modified_base
<222>  (16)..(16)
<223>  Residue modified with phosphorothioate further modified with 
       1-[3-(beta-D-glucopyranosyloxy)propyl] modification

<220>
<221>  modified_base
<222>  (17)..(17)
<223>  Residue modified with phosphorothioate further modified with 
       1-[3-(beta-D-glucopyranosyloxy)propyl] modification

<400>  12
tgtgagtacc actgattc                                                     18


<210>  13
<211>  18
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic polynucleotide


<220>
<221>  modified_base
<222>  (1)..(1)
<223>  Residue modified with phosphorothioate further modified with 
       1-[3-(N-acetyl-2-deoxy-2-amino-beta-D-glucopyranosyloxy)propyl] 
       modification

<220>
<221>  modified_base
<222>  (2)..(2)
<223>  Residue modified with phosphorothioate further modified with 
       1-[3-(N-acetyl-2-deoxy-2-amino-beta-D-glucopyranosyloxy)propyl] 
       modification

<220>
<221>  modified_base
<222>  (3)..(3)
<223>  Residue modified with phosphorothioate further modified with 
       1-[3-(N-acetyl-2-deoxy-2-amino-beta-D-glucopyranosyloxy)propyl] 
       modification

<220>
<221>  modified_base
<222>  (4)..(4)
<223>  Residue modified with phosphorothioate

<220>
<221>  modified_base
<222>  (5)..(5)
<223>  Residue modified with phosphorothioate

<220>
<221>  modified_base
<222>  (6)..(6)
<223>  Residue modified with phosphorothioate

<220>
<221>  modified_base
<222>  (7)..(7)
<223>  Residue modified with phosphorothioate

<220>
<221>  modified_base
<222>  (8)..(8)
<223>  Residue modified with phosphorothioate

<220>
<221>  modified_base
<222>  (9)..(9)
<223>  Residue modified with phosphorothioate

<220>
<221>  modified_base
<222>  (10)..(10)
<223>  Residue modified with phosphorothioate

<220>
<221>  modified_base
<222>  (11)..(11)
<223>  Residue modified with phosphorothioate

<220>
<221>  modified_base
<222>  (12)..(12)
<223>  Residue modified with phosphorothioate

<220>
<221>  modified_base
<222>  (13)..(13)
<223>  Residue modified with phosphorothioate

<220>
<221>  modified_base
<222>  (14)..(14)
<223>  Residue modified with phosphorothioate

<220>
<221>  modified_base
<222>  (15)..(15)
<223>  Residue modified with phosphorothioate further modified with 
       1-[3-(N-acetyl-2-deoxy-2-amino-beta-D-glucopyranosyloxy)propyl] 
       modification

<220>
<221>  modified_base
<222>  (16)..(16)
<223>  Residue modified with phosphorothioate further modified with 
       1-[3-(N-acetyl-2-deoxy-2-amino-beta-D-glucopyranosyloxy)propyl] 
       modification

<220>
<221>  modified_base
<222>  (17)..(17)
<223>  Residue modified with phosphorothioate further modified with 
       1-[3-(N-acetyl-2-deoxy-2-amino-beta-D-glucopyranosyloxy)propyl] 
       modification

<400>  13
tgtgagtacc actgatta                                                     18


<210>  14
<211>  18
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic polynucleotide


<220>
<221>  modified_base
<222>  (1)..(1)
<223>  Residue modified with phosphorothioate further modified with 
       1-[2-[[2-(N-acetyl-2-deoxy-2-amino-beta-D-galactopyranosyloxy) 
       ethyl]oxy]ethyl] modification

<220>
<221>  modified_base
<222>  (2)..(2)
<223>  Residue modified with phosphorothioate further modified with 
       1-[2-[[2-(N-acetyl-2-deoxy-2-amino-beta-D-galactopyranosyloxy) 
       ethyl]oxy]ethyl] modification

<220>
<221>  modified_base
<222>  (3)..(3)
<223>  Residue modified with phosphorothioate further modified with 
       1-[2-[[2-(N-acetyl-2-deoxy-2-amino-beta-D-galactopyranosyloxy) 
       ethyl]oxy]ethyl] modification

<220>
<221>  modified_base
<222>  (4)..(4)
<223>  Residue modified with phosphorothioate

<220>
<221>  modified_base
<222>  (5)..(5)
<223>  Residue modified with phosphorothioate

<220>
<221>  modified_base
<222>  (6)..(6)
<223>  Residue modified with phosphorothioate

<220>
<221>  modified_base
<222>  (7)..(7)
<223>  Residue modified with phosphorothioate

<220>
<221>  modified_base
<222>  (8)..(8)
<223>  Residue modified with phosphorothioate

<220>
<221>  modified_base
<222>  (9)..(9)
<223>  Residue modified with phosphorothioate

<220>
<221>  modified_base
<222>  (10)..(10)
<223>  Residue modified with phosphorothioate

<220>
<221>  modified_base
<222>  (11)..(11)
<223>  Residue modified with phosphorothioate

<220>
<221>  modified_base
<222>  (12)..(12)
<223>  Residue modified with phosphorothioate

<220>
<221>  modified_base
<222>  (13)..(13)
<223>  Residue modified with phosphorothioate

<220>
<221>  modified_base
<222>  (14)..(14)
<223>  Residue modified with phosphorothioate

<220>
<221>  modified_base
<222>  (15)..(15)
<223>  Residue modified with phosphorothioate further modified with 
       1-[2-[[2-(N-acetyl-2-deoxy-2-amino-beta-D-galactopyranosyloxy) 
       ethyl]oxy]ethyl] modification

<220>
<221>  modified_base
<222>  (16)..(16)
<223>  Residue modified with phosphorothioate further modified with 
       1-[2-[[2-(N-acetyl-2-deoxy-2-amino-beta-D-galactopyranosyloxy) 
       ethyl]oxy]ethyl] modification

<220>
<221>  modified_base
<222>  (17)..(17)
<223>  Residue modified with phosphorothioate further modified with 
       1-[2-[[2-(N-acetyl-2-deoxy-2-amino-beta-D-galactopyranosyloxy) 
       ethyl]oxy]ethyl] modification

<400>  14
tgtgagtacc actgatta                                                     18


<210>  15
<211>  18
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic polynucleotide


<220>
<221>  modified_base
<222>  (1)..(1)
<223>  Residue is deoxy residue modified with phosphorothioate further 
       modified with 
       1-[2-[[2-(N-acetyl-2-deoxy-2-amino-beta-D-galactopyranosyloxy) 
       ethyl]oxy]ethyl] modification

<220>
<221>  modified_base
<222>  (2)..(2)
<223>  Residue is deoxy residue modified with phosphorothioate further 
       modified with 
       1-[2-[[2-(N-acetyl-2-deoxy-2-amino-beta-D-galactopyranosyloxy) 
       ethyl]oxy]ethyl] modification

<220>
<221>  modified_base
<222>  (3)..(3)
<223>  Residue is deoxy residue modified with phosphorothioate further 
       modified with 
       1-[2-[[2-(N-acetyl-2-deoxy-2-amino-beta-D-galactopyranosyloxy) 
       ethyl]oxy]ethyl] modification

<220>
<221>  modified_base
<222>  (4)..(4)
<223>  Residue is ribonucleic acid moiety modified with phosphorothioate

<220>
<221>  modified_base
<222>  (5)..(5)
<223>  Residue is ribonucleic acid moiety modified with phosphorothioate

<220>
<221>  modified_base
<222>  (6)..(6)
<223>  Residue is ribonucleic acid moiety modified with phosphorothioate

<220>
<221>  modified_base
<222>  (7)..(7)
<223>  Residue is ribonucleic acid moiety modified with phosphorothioate

<220>
<221>  modified_base
<222>  (8)..(8)
<223>  Residue is ribonucleic acid moiety modified with phosphorothioate

<220>
<221>  modified_base
<222>  (9)..(9)
<223>  Residue is ribonucleic acid moiety modified with phosphorothioate

<220>
<221>  modified_base
<222>  (10)..(10)
<223>  Residue is ribonucleic acid moiety modified with phosphorothioate

<220>
<221>  modified_base
<222>  (11)..(11)
<223>  Residue is ribonucleic acid moiety modified with phosphorothioate

<220>
<221>  modified_base
<222>  (12)..(12)
<223>  Residue is ribonucleic acid moiety modified with phosphorothioate

<220>
<221>  modified_base
<222>  (13)..(13)
<223>  Residue is ribonucleic acid moiety modified with phosphorothioate

<220>
<221>  modified_base
<222>  (14)..(14)
<223>  Residue is ribonucleic acid moiety modified with phosphorothioate

<220>
<221>  modified_base
<222>  (15)..(15)
<223>  Residue is deoxy residue modified with phosphorothioate further 
       modified with 
       1-[2-[[2-(N-acetyl-2-deoxy-2-amino-beta-D-galactopyranosyloxy) 
       ethyl]oxy]ethyl] modification

<220>
<221>  modified_base
<222>  (16)..(16)
<223>  Residue is deoxy residue modified with phosphorothioate further 
       modified with 
       1-[2-[[2-(N-acetyl-2-deoxy-2-amino-beta-D-galactopyranosyloxy) 
       ethyl]oxy]ethyl] modification

<220>
<221>  modified_base
<222>  (17)..(17)
<223>  Residue is deoxy residue modified with phosphorothioate further 
       modified with 
       1-[2-[[2-(N-acetyl-2-deoxy-2-amino-beta-D-galactopyranosyloxy) 
       ethyl]oxy]ethyl] modification

<400>  15
tgtgaguacc acugatta                                                     18


