                         SEQUENCE LISTING

<110>  THE REGENTS OF THE UNIVERSITY OF CALIFORNIA
 
<120>  CYCLIC ADENOSINE MONOPHOSPHATE-INCOMPETENT ADENYLYL CYCLASE AND 
       COMPOSITIONS AND METHODS FOR TREATING HEART FAILURE AND 
       INCREASING CARDIAC FUNCTION

<130>  00015-253WO1/SD-2013-027-1 PCT

<140>  to be assigned
<141>  2014-05-26

<150>  61/832,759
<151>  2013-06-07

<160>  17    

<170>  PatentIn version 3.5

<210>  1
<211>  23
<212>  DNA
<213>  artificial sequence

<220>
<223>  synthetic oligonucleotide

<400>  1
cacatagaag cctagcccac acc                                               23


<210>  2
<211>  22
<212>  DNA
<213>  artificial sequence

<220>
<223>  synthetic oligonucleotide

<400>  2
caggaggcca ctaaaccatg ac                                                22


<210>  3
<211>  20
<212>  DNA
<213>  artificial sequence

<220>
<223>  synthetic oligonucleotide

<400>  3
tgggcctctc tactctgcat                                                   20


<210>  4
<211>  20
<212>  DNA
<213>  artificial sequence

<220>
<223>  synthetic oligonucleotide

<400>  4
tggatgtaac ctcgggtctc                                                   20


<210>  5
<211>  20
<212>  DNA
<213>  artificial sequence

<220>
<223>  synthetic oligonucleotide

<400>  5
ggcattgagt gggactttgt                                                   20


<210>  6
<211>  20
<212>  DNA
<213>  artificial sequence

<220>
<223>  synthetic oligonucleotide

<400>  6
tctgcatcca aacaaacgaa                                                   20


<210>  7
<211>  20
<212>  DNA
<213>  artificial sequence

<220>
<223>  synthetic oligonucleotide

<400>  7
aacctaccag gctgtggatg                                                   20


<210>  8
<211>  20
<212>  DNA
<213>  artificial sequence

<220>
<223>  synthetic oligonucleotide

<400>  8
gactcgatgg gcaagtcaat                                                   20


<210>  9
<211>  30
<212>  PRT
<213>  artificial sequence

<220>
<223>  synthetic peptide

<400>  9

Lys Gly Tyr Gln Leu Glu Cys Arg Gly Val Val Lys Val Lys Gly Lys 
1               5                   10                  15      


Gly Glu Met Thr Thr Tyr Phe Leu Asn Gly Gly Pro Ser Ser 
            20                  25                  30  


<210>  10
<211>  1168
<212>  PRT
<213>  homo sapiien

<400>  10

Met Ser Trp Phe Ser Gly Leu Leu Val Pro Lys Val Asp Glu Arg Lys 
1               5                   10                  15      


Thr Ala Trp Gly Glu Arg Asn Gly Gln Lys Arg Ser Arg Arg Arg Gly 
            20                  25                  30          


Thr Arg Ala Gly Gly Phe Cys Thr Pro Arg Tyr Met Ser Cys Leu Arg 
        35                  40                  45              


Asp Ala Glu Pro Pro Ser Pro Thr Pro Ala Gly Pro Pro Arg Cys Pro 
    50                  55                  60                  


Trp Gln Asp Asp Ala Phe Ile Arg Arg Gly Gly Pro Gly Lys Gly Lys 
65                  70                  75                  80  


Glu Leu Gly Leu Arg Ala Val Ala Leu Gly Phe Glu Asp Thr Glu Val 
                85                  90                  95      


Thr Thr Thr Ala Gly Gly Thr Ala Glu Val Ala Pro Asp Ala Val Pro 
            100                 105                 110         


Arg Ser Gly Arg Ser Cys Trp Arg Arg Leu Val Gln Val Phe Gln Ser 
        115                 120                 125             


Lys Gln Phe Arg Ser Ala Lys Leu Glu Arg Leu Tyr Gln Arg Tyr Phe 
    130                 135                 140                 


Phe Gln Met Asn Gln Ser Ser Leu Thr Leu Leu Met Ala Val Leu Val 
145                 150                 155                 160 


Leu Leu Thr Ala Val Leu Leu Ala Phe His Ala Ala Pro Ala Arg Pro 
                165                 170                 175     


Gln Pro Ala Tyr Val Ala Leu Leu Ala Cys Ala Ala Ala Leu Phe Val 
            180                 185                 190         


Gly Leu Met Val Val Cys Asn Arg His Ser Phe Arg Gln Asp Ser Met 
        195                 200                 205             


Trp Val Val Ser Tyr Val Val Leu Gly Ile Leu Ala Ala Val Gln Val 
    210                 215                 220                 


Gly Gly Ala Leu Ala Ala Asp Pro Arg Ser Pro Ser Ala Gly Leu Trp 
225                 230                 235                 240 


Cys Pro Val Phe Phe Val Tyr Ile Ala Tyr Thr Leu Leu Pro Ile Arg 
                245                 250                 255     


Met Arg Ala Ala Val Leu Ser Gly Leu Gly Leu Ser Thr Leu His Leu 
            260                 265                 270         


Ile Leu Ala Trp Gln Leu Asn Arg Gly Asp Ala Phe Leu Trp Arg Gln 
        275                 280                 285             


Leu Gly Ala Asn Val Leu Leu Phe Leu Cys Thr Asn Val Ile Gly Ile 
    290                 295                 300                 


Cys Thr His Tyr Pro Ala Glu Val Ser Gln Arg Gln Ala Phe Gln Glu 
305                 310                 315                 320 


Thr Arg Gly Tyr Ile Gln Ala Arg Leu His Leu Gln His Glu Asn Arg 
                325                 330                 335     


Gln Gln Glu Arg Leu Leu Leu Ser Val Leu Pro Gln His Val Ala Met 
            340                 345                 350         


Glu Met Lys Glu Asp Ile Asn Thr Lys Lys Glu Asp Met Met Phe His 
        355                 360                 365             


Lys Ile Tyr Ile Gln Lys His Asp Asn Val Ser Ile Leu Phe Ala Asp 
    370                 375                 380                 


Ile Glu Gly Phe Thr Ser Leu Ala Ser Gln Cys Thr Ala Gln Glu Leu 
385                 390                 395                 400 


Val Met Thr Leu Asn Glu Leu Phe Ala Arg Phe Asp Lys Leu Ala Ala 
                405                 410                 415     


Glu Asn His Cys Leu Arg Ile Lys Ile Leu Gly Asp Cys Tyr Tyr Cys 
            420                 425                 430         


Val Ser Gly Leu Pro Glu Ala Arg Ala Asp His Ala His Cys Cys Val 
        435                 440                 445             


Glu Met Gly Val Asp Met Ile Glu Ala Ile Ser Leu Val Arg Glu Val 
    450                 455                 460                 


Thr Gly Val Asn Val Asn Met Arg Val Gly Ile His Ser Gly Arg Val 
465                 470                 475                 480 


His Cys Gly Val Leu Gly Leu Arg Lys Trp Gln Phe Asp Val Trp Ser 
                485                 490                 495     


Asn Asp Val Thr Leu Ala Asn His Met Glu Ala Gly Gly Arg Ala Gly 
            500                 505                 510         


Arg Ile His Ile Thr Arg Ala Thr Leu Gln Tyr Leu Asn Gly Asp Tyr 
        515                 520                 525             


Glu Val Glu Pro Gly Arg Gly Gly Glu Arg Asn Ala Tyr Leu Lys Glu 
    530                 535                 540                 


Gln His Ile Glu Thr Phe Leu Ile Leu Gly Ala Ser Gln Lys Arg Lys 
545                 550                 555                 560 


Glu Glu Lys Ala Met Leu Ala Lys Leu Gln Arg Thr Arg Ala Asn Ser 
                565                 570                 575     


Met Glu Gly Leu Met Pro Arg Trp Val Pro Asp Arg Ala Phe Ser Arg 
            580                 585                 590         


Thr Lys Asp Ser Lys Ala Phe Arg Gln Met Gly Ile Asp Asp Ser Ser 
        595                 600                 605             


Lys Asp Asn Arg Gly Thr Gln Asp Ala Leu Asn Pro Glu Asp Glu Val 
    610                 615                 620                 


Asp Glu Phe Leu Ser Arg Ala Ile Asp Ala Arg Ser Ile Asp Gln Leu 
625                 630                 635                 640 


Arg Lys Asp His Val Arg Arg Phe Leu Leu Thr Phe Gln Arg Glu Asp 
                645                 650                 655     


Leu Glu Lys Lys Tyr Ser Arg Lys Val Asp Pro Arg Phe Gly Ala Tyr 
            660                 665                 670         


Val Ala Cys Ala Leu Leu Val Phe Cys Phe Ile Cys Phe Ile Gln Leu 
        675                 680                 685             


Leu Ile Phe Pro His Ser Thr Leu Met Leu Gly Ile Tyr Ala Ser Ile 
    690                 695                 700                 


Phe Leu Leu Leu Leu Ile Thr Val Leu Ile Cys Ala Val Tyr Ser Cys 
705                 710                 715                 720 


Gly Ser Leu Phe Pro Lys Ala Leu Gln Arg Leu Ser Arg Ser Ile Val 
                725                 730                 735     


Arg Ser Arg Ala His Ser Thr Ala Val Gly Ile Phe Ser Val Leu Leu 
            740                 745                 750         


Val Phe Thr Ser Ala Ile Ala Asn Met Phe Thr Cys Asn His Thr Pro 
        755                 760                 765             


Ile Arg Ser Cys Ala Ala Arg Met Leu Asn Leu Thr Pro Ala Asp Ile 
    770                 775                 780                 


Thr Ala Cys His Leu Gln Gln Leu Asn Tyr Ser Leu Gly Leu Asp Ala 
785                 790                 795                 800 


Pro Leu Cys Glu Gly Thr Met Pro Thr Cys Ser Phe Pro Glu Tyr Phe 
                805                 810                 815     


Ile Gly Asn Met Leu Leu Ser Leu Leu Ala Ser Ser Val Phe Leu His 
            820                 825                 830         


Ile Ser Ser Ile Gly Lys Leu Ala Met Ile Phe Val Leu Gly Leu Ile 
        835                 840                 845             


Tyr Leu Val Leu Leu Leu Leu Gly Pro Pro Ala Thr Ile Phe Asp Asn 
    850                 855                 860                 


Tyr Asp Leu Leu Leu Gly Val His Gly Leu Ala Ser Ser Asn Glu Thr 
865                 870                 875                 880 


Phe Asp Gly Leu Asp Cys Pro Ala Ala Gly Arg Val Ala Leu Lys Tyr 
                885                 890                 895     


Met Thr Pro Val Ile Leu Leu Val Phe Ala Leu Ala Leu Tyr Leu His 
            900                 905                 910         


Ala Gln Gln Val Glu Ser Thr Ala Arg Leu Asp Phe Leu Trp Lys Leu 
        915                 920                 925             


Gln Ala Thr Gly Glu Lys Glu Glu Met Glu Glu Leu Gln Ala Tyr Asn 
    930                 935                 940                 


Arg Arg Leu Leu His Asn Ile Leu Pro Lys Asp Val Ala Ala His Phe 
945                 950                 955                 960 


Leu Ala Arg Glu Arg Arg Asn Asp Glu Leu Tyr Tyr Gln Ser Cys Glu 
                965                 970                 975     


Cys Val Ala Val Met Phe Ala Ser Ile Ala Asn Phe Ser Glu Phe Tyr 
            980                 985                 990         


Val Glu Leu Glu Ala Asn Asn Glu  Gly Val Glu Cys Leu  Arg Leu Leu 
        995                 1000                 1005             


Asn Glu  Ile Ile Ala Asp Phe  Asp Glu Ile Ile Ser  Glu Glu Arg 
    1010                 1015                 1020             


Phe Arg  Gln Leu Glu Lys Ile  Lys Thr Ile Gly Ser  Thr Tyr Met 
    1025                 1030                 1035             


Ala Ala  Ser Gly Leu Asn Ala  Ser Thr Tyr Asp Gln  Val Gly Arg 
    1040                 1045                 1050             


Ser His  Ile Thr Ala Leu Ala  Asp Tyr Ala Met Arg  Leu Met Glu 
    1055                 1060                 1065             


Gln Met  Lys His Ile Asn Glu  His Ser Phe Asn Asn  Phe Gln Met 
    1070                 1075                 1080             


Lys Ile  Gly Leu Asn Met Gly  Pro Val Val Ala Gly  Val Ile Gly 
    1085                 1090                 1095             


Ala Arg  Lys Pro Gln Tyr Asp  Ile Trp Gly Asn Thr  Val Asn Val 
    1100                 1105                 1110             


Ser Ser  Arg Met Asp Ser Thr  Gly Val Pro Asp Arg  Ile Gln Val 
    1115                 1120                 1125             


Thr Thr  Asp Leu Tyr Gln Val  Leu Ala Ala Lys Gly  Tyr Gln Leu 
    1130                 1135                 1140             


Glu Cys  Arg Gly Val Val Lys  Val Lys Gly Lys Gly  Glu Met Thr 
    1145                 1150                 1155             


Thr Tyr  Phe Leu Asn Gly Gly  Pro Ser Ser 
    1160                 1165             


<210>  11
<211>  1176
<212>  PRT
<213>  mus musculus

<400>  11

Met Pro Thr Ser Pro Arg Pro Val Ala Ser Met Ser Trp Phe Ser Gly 
1               5                   10                  15      


Leu Leu Val Pro Lys Val Asp Glu Arg Lys Thr Ala Trp Gly Glu Arg 
            20                  25                  30          


Asn Gly Gln Lys Arg Pro Arg His Ala Asn Arg Ala Ser Gly Phe Cys 
        35                  40                  45              


Ala Pro Arg Tyr Met Ser Cys Leu Lys Asn Ala Glu Pro Pro Ser Pro 
    50                  55                  60                  


Thr Pro Ala Ala His Thr Arg Cys Pro Trp Gln Asp Glu Ala Phe Ile 
65                  70                  75                  80  


Arg Arg Ala Gly Pro Gly Arg Gly Val Glu Leu Gly Leu Arg Ser Val 
                85                  90                  95      


Ala Leu Gly Phe Asp Asp Thr Glu Val Thr Thr Pro Met Gly Thr Ala 
            100                 105                 110         


Glu Val Ala Pro Asp Thr Ser Pro Arg Ser Gly Pro Ser Cys Trp His 
        115                 120                 125             


Arg Leu Val Gln Val Phe Gln Ser Lys Gln Phe Arg Ser Ala Lys Leu 
    130                 135                 140                 


Glu Arg Leu Tyr Gln Arg Tyr Phe Phe Gln Met Asn Gln Ser Ser Leu 
145                 150                 155                 160 


Thr Leu Leu Met Ala Val Leu Val Leu Leu Met Ala Val Leu Leu Thr 
                165                 170                 175     


Phe His Ala Ala Pro Ala Gln Pro Gln Pro Ala Tyr Val Ala Leu Leu 
            180                 185                 190         


Thr Cys Ala Ser Val Leu Phe Val Val Leu Met Val Val Cys Asn Arg 
        195                 200                 205             


His Ser Phe Arg Gln Asp Ser Met Trp Val Val Ser Tyr Val Val Leu 
    210                 215                 220                 


Gly Ile Leu Ala Ala Val Gln Val Gly Gly Ala Leu Ala Ala Asn Pro 
225                 230                 235                 240 


His Ser Pro Ser Ala Gly Leu Trp Cys Pro Val Phe Phe Val Tyr Ile 
                245                 250                 255     


Thr Tyr Thr Leu Leu Pro Ile Arg Met Arg Ala Ala Val Leu Ser Gly 
            260                 265                 270         


Leu Gly Leu Ser Thr Leu His Leu Ile Leu Ala Trp Gln Leu Asn Ser 
        275                 280                 285             


Ser Asp Pro Phe Leu Trp Lys Gln Leu Gly Ala Asn Val Val Leu Phe 
    290                 295                 300                 


Leu Cys Thr Asn Ala Ile Gly Val Cys Thr His Tyr Pro Ala Glu Val 
305                 310                 315                 320 


Ser Gln Arg Gln Ala Phe Gln Glu Thr Arg Gly Tyr Ile Gln Ala Arg 
                325                 330                 335     


Leu His Leu Gln His Glu Asn Arg Gln Gln Glu Arg Leu Leu Leu Ser 
            340                 345                 350         


Val Leu Pro Gln His Val Ala Met Glu Met Lys Glu Asp Ile Asn Thr 
        355                 360                 365             


Lys Lys Glu Asp Met Met Phe His Lys Ile Tyr Ile Gln Lys His Asp 
    370                 375                 380                 


Asn Val Ser Ile Leu Phe Ala Asp Ile Glu Gly Phe Thr Ser Leu Ala 
385                 390                 395                 400 


Ser Gln Cys Thr Ala Gln Glu Leu Val Met Thr Leu Asn Glu Leu Phe 
                405                 410                 415     


Ala Arg Phe Asp Lys Leu Ala Ala Glu Asn His Cys Leu Arg Ile Lys 
            420                 425                 430         


Ile Leu Gly Asp Cys Tyr Tyr Cys Val Ser Gly Leu Pro Glu Ala Arg 
        435                 440                 445             


Ala Asp His Ala His Cys Cys Val Glu Met Gly Val Asp Met Ile Glu 
    450                 455                 460                 


Ala Ile Ser Leu Val Arg Glu Val Thr Gly Val Asn Val Asn Met Arg 
465                 470                 475                 480 


Val Gly Ile His Ser Gly Arg Val His Cys Gly Val Leu Gly Leu Arg 
                485                 490                 495     


Lys Trp Gln Phe Asp Val Trp Ser Asn Asp Val Thr Leu Ala Asn His 
            500                 505                 510         


Met Glu Ala Gly Gly Arg Ala Gly Arg Ile His Ile Thr Arg Ala Thr 
        515                 520                 525             


Leu Gln Tyr Leu Asn Gly Asp Tyr Glu Val Glu Pro Gly Arg Gly Gly 
    530                 535                 540                 


Glu Arg Asn Ala Tyr Leu Lys Glu Gln Cys Ile Glu Thr Phe Leu Ile 
545                 550                 555                 560 


Leu Gly Ala Ser Gln Lys Arg Lys Glu Glu Lys Ala Met Leu Ala Lys 
                565                 570                 575     


Leu Gln Arg Thr Arg Ala Asn Ser Met Glu Gly Leu Met Pro Arg Trp 
            580                 585                 590         


Val Pro Asp Arg Ala Phe Ser Arg Thr Lys Asp Ser Lys Ala Phe Arg 
        595                 600                 605             


Gln Met Gly Ile Asp Asp Ser Ser Lys Asp Asn Arg Gly Ala Gln Asp 
    610                 615                 620                 


Ala Leu Asn Pro Glu Asp Glu Val Asp Glu Phe Leu Gly Arg Ala Ile 
625                 630                 635                 640 


Asp Ala Arg Ser Ile Asp Gln Leu Arg Lys Asp His Val Arg Arg Phe 
                645                 650                 655     


Leu Leu Thr Phe Gln Arg Glu Asp Leu Glu Lys Lys Tyr Ser Arg Lys 
            660                 665                 670         


Val Asp Pro Arg Phe Gly Ala Tyr Val Ala Cys Ala Leu Leu Val Phe 
        675                 680                 685             


Cys Phe Ile Cys Phe Ile Gln Leu Leu Val Phe Pro Tyr Ser Thr Leu 
    690                 695                 700                 


Ile Leu Gly Ile Tyr Ala Ala Ile Phe Leu Leu Leu Leu Val Thr Val 
705                 710                 715                 720 


Leu Ile Cys Ala Val Cys Ser Cys Gly Ser Phe Phe Pro Lys Ala Leu 
                725                 730                 735     


Gln Arg Leu Ser Arg Asn Ile Val Arg Ser Arg Val His Ser Thr Ala 
            740                 745                 750         


Val Gly Ile Phe Ser Val Leu Leu Val Phe Ile Ser Ala Ile Ala Asn 
        755                 760                 765             


Met Phe Thr Cys Asn His Thr Pro Ile Arg Thr Cys Ala Ala Arg Met 
    770                 775                 780                 


Leu Asn Leu Thr Pro Ala Asp Val Thr Ala Cys His Leu Gln Gln Leu 
785                 790                 795                 800 


Asn Tyr Ser Leu Gly Leu Asp Ala Pro Leu Cys Glu Gly Thr Ala Pro 
                805                 810                 815     


Thr Cys Ser Phe Pro Glu Tyr Phe Val Gly Asn Val Leu Leu Ser Leu 
            820                 825                 830         


Leu Ala Ser Ser Val Phe Leu His Ile Ser Ser Ile Gly Lys Leu Ala 
        835                 840                 845             


Met Thr Phe Ile Leu Gly Phe Thr Tyr Leu Val Leu Leu Leu Leu Gly 
    850                 855                 860                 


Pro Pro Ala Ala Ile Phe Asp Asn Tyr Asp Leu Leu Leu Gly Val His 
865                 870                 875                 880 


Gly Leu Ala Ser Ser Asn Glu Thr Phe Asp Gly Leu Asp Cys Pro Ala 
                885                 890                 895     


Val Gly Arg Val Ala Leu Lys Tyr Met Thr Pro Val Ile Leu Leu Val 
            900                 905                 910         


Phe Ala Leu Ala Leu Tyr Leu His Ala Gln Gln Val Glu Ser Thr Ala 
        915                 920                 925             


Arg Leu Asp Phe Leu Trp Lys Leu Gln Ala Thr Gly Glu Lys Glu Glu 
    930                 935                 940                 


Met Glu Glu Leu Gln Ala Tyr Asn Arg Arg Leu Leu His Asn Ile Leu 
945                 950                 955                 960 


Pro Lys Asp Val Ala Ala His Phe Leu Ala Arg Glu Arg Arg Asn Asp 
                965                 970                 975     


Glu Leu Tyr Tyr Gln Ser Cys Glu Cys Val Ala Val Met Phe Ala Ser 
            980                 985                 990         


Ile Ala Asn Phe Ser Glu Phe Tyr  Val Glu Leu Glu Ala  Asn Asn Glu 
        995                 1000                 1005             


Gly Val  Glu Cys Leu Arg Leu  Leu Asn Glu Ile Ile  Ala Asp Phe 
    1010                 1015                 1020             


Asp Glu  Ile Ile Ser Glu Glu  Arg Phe Arg Gln Leu  Glu Lys Ile 
    1025                 1030                 1035             


Lys Thr  Ile Gly Ser Thr Tyr  Met Ala Ala Ser Gly  Leu Asn Ala 
    1040                 1045                 1050             


Ser Thr  Tyr Asp Gln Val Gly  Arg Ser His Ile Thr  Ala Leu Ala 
    1055                 1060                 1065             


Asp Tyr  Ala Met Arg Leu Met  Glu Gln Met Lys His  Ile Asn Glu 
    1070                 1075                 1080             


His Ser  Phe Asn Asn Phe Gln  Met Lys Ile Gly Leu  Asn Met Gly 
    1085                 1090                 1095             


Pro Val  Val Ala Gly Val Ile  Gly Ala Arg Lys Pro  Gln Tyr Asp 
    1100                 1105                 1110             


Ile Trp  Gly Asn Thr Val Asn  Val Ser Ser Arg Met  Asp Ser Thr 
    1115                 1120                 1125             


Gly Val  Pro Asp Arg Ile Gln  Val Thr Thr Asp Leu  Tyr Gln Val 
    1130                 1135                 1140             


Leu Ala  Ala Lys Gly Tyr Gln  Leu Glu Cys Arg Gly  Val Val Lys 
    1145                 1150                 1155             


Val Lys  Gly Lys Gly Glu Met  Thr Thr Tyr Phe Leu  Asn Gly Gly 
    1160                 1165                 1170             


Pro Ser  Ser 
    1175     


<210>  12
<211>  1176
<212>  PRT
<213>  artificial sequence

<220>
<223>  synthetic polypeptide

<400>  12

Met Pro Thr Ser Pro Arg Pro Val Ala Ser Met Ser Trp Phe Ser Gly 
1               5                   10                  15      


Leu Leu Val Pro Lys Val Asp Glu Arg Lys Thr Ala Trp Gly Glu Arg 
            20                  25                  30          


Asn Gly Gln Lys Arg Pro Arg His Ala Asn Arg Ala Ser Gly Phe Cys 
        35                  40                  45              


Ala Pro Arg Tyr Met Ser Cys Leu Lys Asn Ala Glu Pro Pro Ser Pro 
    50                  55                  60                  


Thr Pro Ala Ala His Thr Arg Cys Pro Trp Gln Asp Glu Ala Phe Ile 
65                  70                  75                  80  


Arg Arg Ala Gly Pro Gly Arg Gly Val Glu Leu Gly Leu Arg Ser Val 
                85                  90                  95      


Ala Leu Gly Phe Asp Asp Thr Glu Val Thr Thr Pro Met Gly Thr Ala 
            100                 105                 110         


Glu Val Ala Pro Asp Thr Ser Pro Arg Ser Gly Pro Ser Cys Trp His 
        115                 120                 125             


Arg Leu Val Gln Val Phe Gln Ser Lys Gln Phe Arg Ser Ala Lys Leu 
    130                 135                 140                 


Glu Arg Leu Tyr Gln Arg Tyr Phe Phe Gln Met Asn Gln Ser Ser Leu 
145                 150                 155                 160 


Thr Leu Leu Met Ala Val Leu Val Leu Leu Met Ala Val Leu Leu Thr 
                165                 170                 175     


Phe His Ala Ala Pro Ala Gln Pro Gln Pro Ala Tyr Val Ala Leu Leu 
            180                 185                 190         


Thr Cys Ala Ser Val Leu Phe Val Val Leu Met Val Val Cys Asn Arg 
        195                 200                 205             


His Ser Phe Arg Gln Asp Ser Met Trp Val Val Ser Tyr Val Val Leu 
    210                 215                 220                 


Gly Ile Leu Ala Ala Val Gln Val Gly Gly Ala Leu Ala Ala Asn Pro 
225                 230                 235                 240 


His Ser Pro Ser Ala Gly Leu Trp Cys Pro Val Phe Phe Val Tyr Ile 
                245                 250                 255     


Thr Tyr Thr Leu Leu Pro Ile Arg Met Arg Ala Ala Val Leu Ser Gly 
            260                 265                 270         


Leu Gly Leu Ser Thr Leu His Leu Ile Leu Ala Trp Gln Leu Asn Ser 
        275                 280                 285             


Ser Asp Pro Phe Leu Trp Lys Gln Leu Gly Ala Asn Val Val Leu Phe 
    290                 295                 300                 


Leu Cys Thr Asn Ala Ile Gly Val Cys Thr His Tyr Pro Ala Glu Val 
305                 310                 315                 320 


Ser Gln Arg Gln Ala Phe Gln Glu Thr Arg Gly Tyr Ile Gln Ala Arg 
                325                 330                 335     


Leu His Leu Gln His Glu Asn Arg Gln Gln Glu Arg Leu Leu Leu Ser 
            340                 345                 350         


Val Leu Pro Gln His Val Ala Met Glu Met Lys Glu Asp Ile Asn Thr 
        355                 360                 365             


Lys Lys Glu Asp Met Met Phe His Lys Ile Tyr Ile Gln Lys His Asp 
    370                 375                 380                 


Asn Val Ser Ile Leu Phe Ala Asp Ile Glu Gly Phe Thr Ser Leu Ala 
385                 390                 395                 400 


Ser Gln Cys Thr Ala Gln Glu Leu Val Met Thr Leu Asn Glu Leu Phe 
                405                 410                 415     


Ala Arg Phe Asp Lys Leu Ala Ala Glu Asn His Cys Leu Arg Ile Lys 
            420                 425                 430         


Ile Leu Gly Ala Cys Tyr Tyr Cys Val Ser Gly Leu Pro Glu Ala Arg 
        435                 440                 445             


Ala Asp His Ala His Cys Cys Val Glu Met Gly Val Asp Met Ile Glu 
    450                 455                 460                 


Ala Ile Ser Leu Val Arg Glu Val Thr Gly Val Asn Val Asn Met Arg 
465                 470                 475                 480 


Val Gly Ile His Ser Gly Arg Val His Cys Gly Val Leu Gly Leu Arg 
                485                 490                 495     


Lys Trp Gln Phe Asp Val Trp Ser Asn Asp Val Thr Leu Ala Asn His 
            500                 505                 510         


Met Glu Ala Gly Gly Arg Ala Gly Arg Ile His Ile Thr Arg Ala Thr 
        515                 520                 525             


Leu Gln Tyr Leu Asn Gly Asp Tyr Glu Val Glu Pro Gly Arg Gly Gly 
    530                 535                 540                 


Glu Arg Asn Ala Tyr Leu Lys Glu Gln Cys Ile Glu Thr Phe Leu Ile 
545                 550                 555                 560 


Leu Gly Ala Ser Gln Lys Arg Lys Glu Glu Lys Ala Met Leu Ala Lys 
                565                 570                 575     


Leu Gln Arg Thr Arg Ala Asn Ser Met Glu Gly Leu Met Pro Arg Trp 
            580                 585                 590         


Val Pro Asp Arg Ala Phe Ser Arg Thr Lys Asp Ser Lys Ala Phe Arg 
        595                 600                 605             


Gln Met Gly Ile Asp Asp Ser Ser Lys Asp Asn Arg Gly Ala Gln Asp 
    610                 615                 620                 


Ala Leu Asn Pro Glu Asp Glu Val Asp Glu Phe Leu Gly Arg Ala Ile 
625                 630                 635                 640 


Asp Ala Arg Ser Ile Asp Gln Leu Arg Lys Asp His Val Arg Arg Phe 
                645                 650                 655     


Leu Leu Thr Phe Gln Arg Glu Asp Leu Glu Lys Lys Tyr Ser Arg Lys 
            660                 665                 670         


Val Asp Pro Arg Phe Gly Ala Tyr Val Ala Cys Ala Leu Leu Val Phe 
        675                 680                 685             


Cys Phe Ile Cys Phe Ile Gln Leu Leu Val Phe Pro Tyr Ser Thr Leu 
    690                 695                 700                 


Ile Leu Gly Ile Tyr Ala Ala Ile Phe Leu Leu Leu Leu Val Thr Val 
705                 710                 715                 720 


Leu Ile Cys Ala Val Cys Ser Cys Gly Ser Phe Phe Pro Lys Ala Leu 
                725                 730                 735     


Gln Arg Leu Ser Arg Asn Ile Val Arg Ser Arg Val His Ser Thr Ala 
            740                 745                 750         


Val Gly Ile Phe Ser Val Leu Leu Val Phe Ile Ser Ala Ile Ala Asn 
        755                 760                 765             


Met Phe Thr Cys Asn His Thr Pro Ile Arg Thr Cys Ala Ala Arg Met 
    770                 775                 780                 


Leu Asn Leu Thr Pro Ala Asp Val Thr Ala Cys His Leu Gln Gln Leu 
785                 790                 795                 800 


Asn Tyr Ser Leu Gly Leu Asp Ala Pro Leu Cys Glu Gly Thr Ala Pro 
                805                 810                 815     


Thr Cys Ser Phe Pro Glu Tyr Phe Val Gly Asn Val Leu Leu Ser Leu 
            820                 825                 830         


Leu Ala Ser Ser Val Phe Leu His Ile Ser Ser Ile Gly Lys Leu Ala 
        835                 840                 845             


Met Thr Phe Ile Leu Gly Phe Thr Tyr Leu Val Leu Leu Leu Leu Gly 
    850                 855                 860                 


Pro Pro Ala Ala Ile Phe Asp Asn Tyr Asp Leu Leu Leu Gly Val His 
865                 870                 875                 880 


Gly Leu Ala Ser Ser Asn Glu Thr Phe Asp Gly Leu Asp Cys Pro Ala 
                885                 890                 895     


Val Gly Arg Val Ala Leu Lys Tyr Met Thr Pro Val Ile Leu Leu Val 
            900                 905                 910         


Phe Ala Leu Ala Leu Tyr Leu His Ala Gln Gln Val Glu Ser Thr Ala 
        915                 920                 925             


Arg Leu Asp Phe Leu Trp Lys Leu Gln Ala Thr Gly Glu Lys Glu Glu 
    930                 935                 940                 


Met Glu Glu Leu Gln Ala Tyr Asn Arg Arg Leu Leu His Asn Ile Leu 
945                 950                 955                 960 


Pro Lys Asp Val Ala Ala His Phe Leu Ala Arg Glu Arg Arg Asn Asp 
                965                 970                 975     


Glu Leu Tyr Tyr Gln Ser Cys Glu Cys Val Ala Val Met Phe Ala Ser 
            980                 985                 990         


Ile Ala Asn Phe Ser Glu Phe Tyr  Val Glu Leu Glu Ala  Asn Asn Glu 
        995                 1000                 1005             


Gly Val  Glu Cys Leu Arg Leu  Leu Asn Glu Ile Ile  Ala Asp Phe 
    1010                 1015                 1020             


Asp Glu  Ile Ile Ser Glu Glu  Arg Phe Arg Gln Leu  Glu Lys Ile 
    1025                 1030                 1035             


Lys Thr  Ile Gly Ser Thr Tyr  Met Ala Ala Ser Gly  Leu Asn Ala 
    1040                 1045                 1050             


Ser Thr  Tyr Asp Gln Val Gly  Arg Ser His Ile Thr  Ala Leu Ala 
    1055                 1060                 1065             


Asp Tyr  Ala Met Arg Leu Met  Glu Gln Met Lys His  Ile Asn Glu 
    1070                 1075                 1080             


His Ser  Phe Asn Asn Phe Gln  Met Lys Ile Gly Leu  Asn Met Gly 
    1085                 1090                 1095             


Pro Val  Val Ala Gly Val Ile  Gly Ala Arg Lys Pro  Gln Tyr Asp 
    1100                 1105                 1110             


Ile Trp  Gly Asn Thr Val Asn  Val Ser Ser Arg Met  Asp Ser Thr 
    1115                 1120                 1125             


Gly Val  Pro Asp Arg Ile Gln  Val Thr Thr Asp Leu  Tyr Gln Val 
    1130                 1135                 1140             


Leu Ala  Ala Lys Gly Tyr Gln  Leu Glu Cys Arg Gly  Val Val Lys 
    1145                 1150                 1155             


Val Lys  Gly Lys Gly Glu Met  Thr Thr Tyr Phe Leu  Asn Gly Gly 
    1160                 1165                 1170             


Pro Ser  Ser 
    1175     


<210>  13
<211>  1168
<212>  PRT
<213>  artificial sequence

<220>
<223>  synthetic polypeptide

<400>  13

Met Ser Trp Phe Ser Gly Leu Leu Val Pro Lys Val Asp Glu Arg Lys 
1               5                   10                  15      


Thr Ala Trp Gly Glu Arg Asn Gly Gln Lys Arg Ser Arg Arg Arg Gly 
            20                  25                  30          


Thr Arg Ala Gly Gly Phe Cys Thr Pro Arg Tyr Met Ser Cys Leu Arg 
        35                  40                  45              


Asp Ala Glu Pro Pro Ser Pro Thr Pro Ala Gly Pro Pro Arg Cys Pro 
    50                  55                  60                  


Trp Gln Asp Asp Ala Phe Ile Arg Arg Gly Gly Pro Gly Lys Gly Lys 
65                  70                  75                  80  


Glu Leu Gly Leu Arg Ala Val Ala Leu Gly Phe Glu Asp Thr Glu Val 
                85                  90                  95      


Thr Thr Thr Ala Gly Gly Thr Ala Glu Val Ala Pro Asp Ala Val Pro 
            100                 105                 110         


Arg Ser Gly Arg Ser Cys Trp Arg Arg Leu Val Gln Val Phe Gln Ser 
        115                 120                 125             


Lys Gln Phe Arg Ser Ala Lys Leu Glu Arg Leu Tyr Gln Arg Tyr Phe 
    130                 135                 140                 


Phe Gln Met Asn Gln Ser Ser Leu Thr Leu Leu Met Ala Val Leu Val 
145                 150                 155                 160 


Leu Leu Thr Ala Val Leu Leu Ala Phe His Ala Ala Pro Ala Arg Pro 
                165                 170                 175     


Gln Pro Ala Tyr Val Ala Leu Leu Ala Cys Ala Ala Ala Leu Phe Val 
            180                 185                 190         


Gly Leu Met Val Val Cys Asn Arg His Ser Phe Arg Gln Asp Ser Met 
        195                 200                 205             


Trp Val Val Ser Tyr Val Val Leu Gly Ile Leu Ala Ala Val Gln Val 
    210                 215                 220                 


Gly Gly Ala Leu Ala Ala Asp Pro Arg Ser Pro Ser Ala Gly Leu Trp 
225                 230                 235                 240 


Cys Pro Val Phe Phe Val Tyr Ile Ala Tyr Thr Leu Leu Pro Ile Arg 
                245                 250                 255     


Met Arg Ala Ala Val Leu Ser Gly Leu Gly Leu Ser Thr Leu His Leu 
            260                 265                 270         


Ile Leu Ala Trp Gln Leu Asn Arg Gly Asp Ala Phe Leu Trp Arg Gln 
        275                 280                 285             


Leu Gly Ala Asn Val Leu Leu Phe Leu Cys Thr Asn Val Ile Gly Ile 
    290                 295                 300                 


Cys Thr His Tyr Pro Ala Glu Val Ser Gln Arg Gln Ala Phe Gln Glu 
305                 310                 315                 320 


Thr Arg Gly Tyr Ile Gln Ala Arg Leu His Leu Gln His Glu Asn Arg 
                325                 330                 335     


Gln Gln Glu Arg Leu Leu Leu Ser Val Leu Pro Gln His Val Ala Met 
            340                 345                 350         


Glu Met Lys Glu Asp Ile Asn Thr Lys Lys Glu Asp Met Met Phe His 
        355                 360                 365             


Lys Ile Tyr Ile Gln Lys His Asp Asn Val Ser Ile Leu Phe Ala Asp 
    370                 375                 380                 


Ile Glu Gly Phe Thr Ser Leu Ala Ser Gln Cys Thr Ala Gln Glu Leu 
385                 390                 395                 400 


Val Met Thr Leu Asn Glu Leu Phe Ala Arg Phe Asp Lys Leu Ala Ala 
                405                 410                 415     


Glu Asn His Cys Leu Arg Ile Lys Ile Leu Gly Ala Cys Tyr Tyr Cys 
            420                 425                 430         


Val Ser Gly Leu Pro Glu Ala Arg Ala Asp His Ala His Cys Cys Val 
        435                 440                 445             


Glu Met Gly Val Asp Met Ile Glu Ala Ile Ser Leu Val Arg Glu Val 
    450                 455                 460                 


Thr Gly Val Asn Val Asn Met Arg Val Gly Ile His Ser Gly Arg Val 
465                 470                 475                 480 


His Cys Gly Val Leu Gly Leu Arg Lys Trp Gln Phe Asp Val Trp Ser 
                485                 490                 495     


Asn Asp Val Thr Leu Ala Asn His Met Glu Ala Gly Gly Arg Ala Gly 
            500                 505                 510         


Arg Ile His Ile Thr Arg Ala Thr Leu Gln Tyr Leu Asn Gly Asp Tyr 
        515                 520                 525             


Glu Val Glu Pro Gly Arg Gly Gly Glu Arg Asn Ala Tyr Leu Lys Glu 
    530                 535                 540                 


Gln His Ile Glu Thr Phe Leu Ile Leu Gly Ala Ser Gln Lys Arg Lys 
545                 550                 555                 560 


Glu Glu Lys Ala Met Leu Ala Lys Leu Gln Arg Thr Arg Ala Asn Ser 
                565                 570                 575     


Met Glu Gly Leu Met Pro Arg Trp Val Pro Asp Arg Ala Phe Ser Arg 
            580                 585                 590         


Thr Lys Asp Ser Lys Ala Phe Arg Gln Met Gly Ile Asp Asp Ser Ser 
        595                 600                 605             


Lys Asp Asn Arg Gly Thr Gln Asp Ala Leu Asn Pro Glu Asp Glu Val 
    610                 615                 620                 


Asp Glu Phe Leu Ser Arg Ala Ile Asp Ala Arg Ser Ile Asp Gln Leu 
625                 630                 635                 640 


Arg Lys Asp His Val Arg Arg Phe Leu Leu Thr Phe Gln Arg Glu Asp 
                645                 650                 655     


Leu Glu Lys Lys Tyr Ser Arg Lys Val Asp Pro Arg Phe Gly Ala Tyr 
            660                 665                 670         


Val Ala Cys Ala Leu Leu Val Phe Cys Phe Ile Cys Phe Ile Gln Leu 
        675                 680                 685             


Leu Ile Phe Pro His Ser Thr Leu Met Leu Gly Ile Tyr Ala Ser Ile 
    690                 695                 700                 


Phe Leu Leu Leu Leu Ile Thr Val Leu Ile Cys Ala Val Tyr Ser Cys 
705                 710                 715                 720 


Gly Ser Leu Phe Pro Lys Ala Leu Gln Arg Leu Ser Arg Ser Ile Val 
                725                 730                 735     


Arg Ser Arg Ala His Ser Thr Ala Val Gly Ile Phe Ser Val Leu Leu 
            740                 745                 750         


Val Phe Thr Ser Ala Ile Ala Asn Met Phe Thr Cys Asn His Thr Pro 
        755                 760                 765             


Ile Arg Ser Cys Ala Ala Arg Met Leu Asn Leu Thr Pro Ala Asp Ile 
    770                 775                 780                 


Thr Ala Cys His Leu Gln Gln Leu Asn Tyr Ser Leu Gly Leu Asp Ala 
785                 790                 795                 800 


Pro Leu Cys Glu Gly Thr Met Pro Thr Cys Ser Phe Pro Glu Tyr Phe 
                805                 810                 815     


Ile Gly Asn Met Leu Leu Ser Leu Leu Ala Ser Ser Val Phe Leu His 
            820                 825                 830         


Ile Ser Ser Ile Gly Lys Leu Ala Met Ile Phe Val Leu Gly Leu Ile 
        835                 840                 845             


Tyr Leu Val Leu Leu Leu Leu Gly Pro Pro Ala Thr Ile Phe Asp Asn 
    850                 855                 860                 


Tyr Asp Leu Leu Leu Gly Val His Gly Leu Ala Ser Ser Asn Glu Thr 
865                 870                 875                 880 


Phe Asp Gly Leu Asp Cys Pro Ala Ala Gly Arg Val Ala Leu Lys Tyr 
                885                 890                 895     


Met Thr Pro Val Ile Leu Leu Val Phe Ala Leu Ala Leu Tyr Leu His 
            900                 905                 910         


Ala Gln Gln Val Glu Ser Thr Ala Arg Leu Asp Phe Leu Trp Lys Leu 
        915                 920                 925             


Gln Ala Thr Gly Glu Lys Glu Glu Met Glu Glu Leu Gln Ala Tyr Asn 
    930                 935                 940                 


Arg Arg Leu Leu His Asn Ile Leu Pro Lys Asp Val Ala Ala His Phe 
945                 950                 955                 960 


Leu Ala Arg Glu Arg Arg Asn Asp Glu Leu Tyr Tyr Gln Ser Cys Glu 
                965                 970                 975     


Cys Val Ala Val Met Phe Ala Ser Ile Ala Asn Phe Ser Glu Phe Tyr 
            980                 985                 990         


Val Glu Leu Glu Ala Asn Asn Glu  Gly Val Glu Cys Leu  Arg Leu Leu 
        995                 1000                 1005             


Asn Glu  Ile Ile Ala Asp Phe  Asp Glu Ile Ile Ser  Glu Glu Arg 
    1010                 1015                 1020             


Phe Arg  Gln Leu Glu Lys Ile  Lys Thr Ile Gly Ser  Thr Tyr Met 
    1025                 1030                 1035             


Ala Ala  Ser Gly Leu Asn Ala  Ser Thr Tyr Asp Gln  Val Gly Arg 
    1040                 1045                 1050             


Ser His  Ile Thr Ala Leu Ala  Asp Tyr Ala Met Arg  Leu Met Glu 
    1055                 1060                 1065             


Gln Met  Lys His Ile Asn Glu  His Ser Phe Asn Asn  Phe Gln Met 
    1070                 1075                 1080             


Lys Ile  Gly Leu Asn Met Gly  Pro Val Val Ala Gly  Val Ile Gly 
    1085                 1090                 1095             


Ala Arg  Lys Pro Gln Tyr Asp  Ile Trp Gly Asn Thr  Val Asn Val 
    1100                 1105                 1110             


Ser Ser  Arg Met Asp Ser Thr  Gly Val Pro Asp Arg  Ile Gln Val 
    1115                 1120                 1125             


Thr Thr  Asp Leu Tyr Gln Val  Leu Ala Ala Lys Gly  Tyr Gln Leu 
    1130                 1135                 1140             


Glu Cys  Arg Gly Val Val Lys  Val Lys Gly Lys Gly  Glu Met Thr 
    1145                 1150                 1155             


Thr Tyr  Phe Leu Asn Gly Gly  Pro Ser Ser 
    1160                 1165             


<210>  14
<211>  3537
<212>  DNA
<213>  homo sapiens


<220>
<221>  misc_feature
<222>  (163)..(163)
<223>  n is a, c, g, or t

<400>  14
gaattcgccc ttcggcagca tgtcatggtt tagtggcctc ctggtcccta aagtggatga       60

acggaaaaca gcctggggtg aacgcaatgg gcagaagcgt tcgcggcgcc gtggcactcg      120

ggcaggtggc ttctgcacgc cccgctatat gagctgcctc cgngatgcag agccacccag      180

ccccacccct gcgggccccc ctcggtgccc ctggcaggat gacgccttca tccggagggg      240

cggcccaggc aagggcaagg agctggggct gcgggcagtg gccctgggct tcgaggatac      300

cgaggtgaca acgacagcgg gcgggacggc tgaggtggcg cccgacgcgg tgcccaggag      360

tgggcgatcc tgctggcgcc gtctggtgca ggtgttccag tcgaagcagt tccgttcggc      420

caagctggag cgcctgtacc agcggtactt cttccagatg aaccagagca gcctgacgct      480

gctgatggcg gtgctggtgc tgctcacagc ggtgctgctg gctttccacg ccgcacccgc      540

ccgccctcag cctgcctatg tggcactgtt ggcctgtgcc gccgccctgt tcgtggggct      600

catggtggtg tgtaaccggc atagcttccg ccaggactcc atgtgggtgg tgagttacgt      660

ggtgctgggc atcctggcgg cagtgcaggt cgggggcgct ctcgcagcag acccgcgcag      720

cccctctgcg ggcctctggt gccctgtgtt ctttgtctac atcgcctaca cgctcctccc      780

catccgcatg cgggctgccg tcctcagcgg cctgggcctc tccaccttgc atttgatctt      840

ggcctggcaa cttaaccgtg gtgatgcctt cctctggagg cagctcggtg ccaatgtgct      900

gctgttcctc tgcaccaacg tcattggcat ctgcacacac tatccagcag aggtgtctca      960

gcgccaggcc tttcaggaga cccgcggtta catccaggcc cggctccacc tgcagcatga     1020

gaatcggcag caggagcggc tgctgctgtc ggtattgccc cagcacgtcg ccatggagat     1080

gaaagaagac atcaacacaa aaaaagaaga catgatgttc cacaagatct acatacagaa     1140

gcatgacaat gtcagcatcc tgtttgcaga cattgagggc ttcaccagcc tggcatccca     1200

gtgcactgcg caggagctgg tcatgaccct gaatgagctc tttgcccggt ttgacaagct     1260

ggctgcggag aatcactgcc tgaggatcaa gatcttgggg gactgttact actgtgtgtc     1320

agggctgccg gaggcccggg ccgaccatgc ccactgctgt gtggagatgg gggtagacat     1380

gattgaggcc atctcgctgg tacgtgaggt gacaggtgtg aatgtgaaca tgcgcgtggg     1440

catccacagc gggcgcgtgc actgcggcgt ccttggcttg cggaaatggc agttcgatgt     1500

gtggtccaat gatgtgaccc tggccaacca catggaggca ggaggccggg ctggccgcat     1560

ccacatcact cgggcaacac tgcagtacct gaacggggac tacgaggtgg agccaggccg     1620

tggtggcgag cgcaacgcgt acctcaagga gcagcacatt gagactttcc tcatcctggg     1680

cgccagccag aaacggaaag aggagaaggc catgctggcc aagctgcagc ggactcgggc     1740

caactccatg gaagggctga tgccgcgctg ggttcctgat cgtgccttct cccggaccaa     1800

ggactccaag gccttccgcc agatgggcat tgatgattcc agcaaagaca accggggcac     1860

ccaagatgcc ctgaaccctg aggatgaggt ggatgagttc ctgagccgtg ccatcgatgc     1920

ccgcagcatt gatcagctgc ggaaggacca tgtgcgccgg tttctgctca ccttccagag     1980

agaggatctt gagaagaagt actcccggaa ggtggatccc cgcttcggag cctacgttgc     2040

ctgtgccctg ttggtcttct gcttcatctg cttcatccag cttctcatct tcccacactc     2100

caccctgatg cttgggatct atgccagcat cttcctgctg ctgctaatca ccgtgctgat     2160

ctgtgctgtg tactcctgtg gttctctgtt ccctaaggcc ctgcaacgtc tgtcccgcag     2220

cattgtccgc tcacgggcac atagcaccgc agttggcatc ttttccgtcc tgcttgtgtt     2280

tacttctgcc attgccaaca tgttcacctg taaccacacc cccatacgga gctgtgcagc     2340

ccggatgctg aatttaacac ctgctgacat cactgcctgc cacctgcagc agctcaatta     2400

ctctctgggc ctggatgctc ccctgtgtga gggcaccatg cccacctgca gctttcctga     2460

gtacttcatc gggaacatgc tgctgagtct cttggccagc tctgtcttcc tgcacatcag     2520

cagcatcggg aagttggcca tgatctttgt cttggggctc atctatttgg tgctgcttct     2580

gctgggtccc ccagccacca tctttgacaa ctatgaccta ctgcttggcg tccatggctt     2640

ggcttcttcc aatgagacct ttgatgggct ggactgtcca gctgcaggga gggtggccct     2700

caaatatatg acccctgtga ttctgctggt gtttgcgctg gcgctgtatc tgcatgctca     2760

gcaggtggag tcgactgccc gcctagactt cctctggaaa ctacaggcaa caggggagaa     2820

ggaggagatg gaggagctac aggcatacaa ccggaggctg ctgcataaca ttctgcccaa     2880

ggacgtggcg gcccacttcc tggcccggga gcgccgcaat gatgaactct actatcagtc     2940

gtgtgagtgt gtggctgtta tgtttgcctc cattgccaac ttctctgagt tctatgtgga     3000

gctggaggca aacaatgagg gtgtcgagtg cctgcggctg ctcaacgaga tcatcgctga     3060

ctttgatgag attatcagcg aggagcggtt ccggcagctg gaaaagatca agacgattgg     3120

tagcacctac atggctgcct cagggctgaa cgccagcacc tacgatcagg tgggccgctc     3180

ccacatcact gccctggctg actacgccat gcggctcatg gagcagatga agcacatcaa     3240

tgagcactcc ttcaacaatt tccagatgaa gattgggctg aacatgggcc cagtcgtggc     3300

aggtgtcatc ggggctcgga agccacagta tgacatctgg gggaacacag tgaatgtctc     3360

tagtcgtatg gacagcacgg gggtccccga ccgaatccag gtgaccacgg acctgtacca     3420

ggttctagct gccaagggct accagctgga gtgtcgaggg gtggtcaagg tgaagggcaa     3480

gggggagatg accacctact tcctcaatgg gggccccagc agttaacagg ggaattc        3537


<210>  15
<211>  3537
<212>  DNA
<213>  mus musculus


<220>
<221>  misc_feature
<222>  (163)..(163)
<223>  n is a, c, g, or t

<400>  15
gaattcgccc ttcggcagca tgtcatggtt tagtggcctc ctggtcccta aagtggatga       60

acggaaaaca gcctggggtg aacgcaatgg gcagaagcgt tcgcggcgcc gtggcactcg      120

ggcaggtggc ttctgcacgc cccgctatat gagctgcctc cgngatgcag agccacccag      180

ccccacccct gcgggccccc ctcggtgccc ctggcaggat gacgccttca tccggagggg      240

cggcccaggc aagggcaagg agctggggct gcgggcagtg gccctgggct tcgaggatac      300

cgaggtgaca acgacagcgg gcgggacggc tgaggtggcg cccgacgcgg tgcccaggag      360

tgggcgatcc tgctggcgcc gtctggtgca ggtgttccag tcgaagcagt tccgttcggc      420

caagctggag cgcctgtacc agcggtactt cttccagatg aaccagagca gcctgacgct      480

gctgatggcg gtgctggtgc tgctcacagc ggtgctgctg gctttccacg ccgcacccgc      540

ccgccctcag cctgcctatg tggcactgtt ggcctgtgcc gccgccctgt tcgtggggct      600

catggtggtg tgtaaccggc atagcttccg ccaggactcc atgtgggtgg tgagttacgt      660

ggtgctgggc atcctggcgg cagtgcaggt cgggggcgct ctcgcagcag acccgcgcag      720

cccctctgcg ggcctctggt gccctgtgtt ctttgtctac atcgcctaca cgctcctccc      780

catccgcatg cgggctgccg tcctcagcgg cctgggcctc tccaccttgc atttgatctt      840

ggcctggcaa cttaaccgtg gtgatgcctt cctctggagg cagctcggtg ccaatgtgct      900

gctgttcctc tgcaccaacg tcattggcat ctgcacacac tatccagcag aggtgtctca      960

gcgccaggcc tttcaggaga cccgcggtta catccaggcc cggctccacc tgcagcatga     1020

gaatcggcag caggagcggc tgctgctgtc ggtattgccc cagcacgtcg ccatggagat     1080

gaaagaagac atcaacacaa aaaaagaaga catgatgttc cacaagatct acatacagaa     1140

gcatgacaat gtcagcatcc tgtttgcaga cattgagggc ttcaccagcc tggcatccca     1200

gtgcactgcg caggagctgg tcatgaccct gaatgagctc tttgcccggt ttgacaagct     1260

ggctgcggag aatcactgcc tgaggatcaa gatcttgggg gactgttact actgtgtgtc     1320

agggctgccg gaggcccggg ccgaccatgc ccactgctgt gtggagatgg gggtagacat     1380

gattgaggcc atctcgctgg tacgtgaggt gacaggtgtg aatgtgaaca tgcgcgtggg     1440

catccacagc gggcgcgtgc actgcggcgt ccttggcttg cggaaatggc agttcgatgt     1500

gtggtccaat gatgtgaccc tggccaacca catggaggca ggaggccggg ctggccgcat     1560

ccacatcact cgggcaacac tgcagtacct gaacggggac tacgaggtgg agccaggccg     1620

tggtggcgag cgcaacgcgt acctcaagga gcagcacatt gagactttcc tcatcctggg     1680

cgccagccag aaacggaaag aggagaaggc catgctggcc aagctgcagc ggactcgggc     1740

caactccatg gaagggctga tgccgcgctg ggttcctgat cgtgccttct cccggaccaa     1800

ggactccaag gccttccgcc agatgggcat tgatgattcc agcaaagaca accggggcac     1860

ccaagatgcc ctgaaccctg aggatgaggt ggatgagttc ctgagccgtg ccatcgatgc     1920

ccgcagcatt gatcagctgc ggaaggacca tgtgcgccgg tttctgctca ccttccagag     1980

agaggatctt gagaagaagt actcccggaa ggtggatccc cgcttcggag cctacgttgc     2040

ctgtgccctg ttggtcttct gcttcatctg cttcatccag cttctcatct tcccacactc     2100

caccctgatg cttgggatct atgccagcat cttcctgctg ctgctaatca ccgtgctgat     2160

ctgtgctgtg tactcctgtg gttctctgtt ccctaaggcc ctgcaacgtc tgtcccgcag     2220

cattgtccgc tcacgggcac atagcaccgc agttggcatc ttttccgtcc tgcttgtgtt     2280

tacttctgcc attgccaaca tgttcacctg taaccacacc cccatacgga gctgtgcagc     2340

ccggatgctg aatttaacac ctgctgacat cactgcctgc cacctgcagc agctcaatta     2400

ctctctgggc ctggatgctc ccctgtgtga gggcaccatg cccacctgca gctttcctga     2460

gtacttcatc gggaacatgc tgctgagtct cttggccagc tctgtcttcc tgcacatcag     2520

cagcatcggg aagttggcca tgatctttgt cttggggctc atctatttgg tgctgcttct     2580

gctgggtccc ccagccacca tctttgacaa ctatgaccta ctgcttggcg tccatggctt     2640

ggcttcttcc aatgagacct ttgatgggct ggactgtcca gctgcaggga gggtggccct     2700

caaatatatg acccctgtga ttctgctggt gtttgcgctg gcgctgtatc tgcatgctca     2760

gcaggtggag tcgactgccc gcctagactt cctctggaaa ctacaggcaa caggggagaa     2820

ggaggagatg gaggagctac aggcatacaa ccggaggctg ctgcataaca ttctgcccaa     2880

ggacgtggcg gcccacttcc tggcccggga gcgccgcaat gatgaactct actatcagtc     2940

gtgtgagtgt gtggctgtta tgtttgcctc cattgccaac ttctctgagt tctatgtgga     3000

gctggaggca aacaatgagg gtgtcgagtg cctgcggctg ctcaacgaga tcatcgctga     3060

ctttgatgag attatcagcg aggagcggtt ccggcagctg gaaaagatca agacgattgg     3120

tagcacctac atggctgcct cagggctgaa cgccagcacc tacgatcagg tgggccgctc     3180

ccacatcact gccctggctg actacgccat gcggctcatg gagcagatga agcacatcaa     3240

tgagcactcc ttcaacaatt tccagatgaa gattgggctg aacatgggcc cagtcgtggc     3300

aggtgtcatc ggggctcgga agccacagta tgacatctgg gggaacacag tgaatgtctc     3360

tagtcgtatg gacagcacgg gggtccccga ccgaatccag gtgaccacgg acctgtacca     3420

ggttctagct gccaagggct accagctgga gtgtcgaggg gtggtcaagg tgaagggcaa     3480

gggggagatg accacctact tcctcaatgg gggccccagc agttaacagg ggaattc        3537


<210>  16
<211>  1166
<212>  PRT
<213>  mus musculus

<400>  16

Met Ser Trp Phe Ser Gly Leu Leu Val Pro Lys Val Asp Glu Arg Lys 
1               5                   10                  15      


Thr Ala Trp Gly Glu Arg Asn Gly Gln Lys Arg Pro Arg His Ala Asn 
            20                  25                  30          


Arg Ala Ser Gly Phe Cys Ala Pro Arg Tyr Met Ser Cys Leu Lys Asn 
        35                  40                  45              


Ala Glu Pro Pro Ser Pro Thr Pro Ala Ala His Thr Arg Cys Pro Trp 
    50                  55                  60                  


Gln Asp Glu Ala Phe Ile Arg Arg Ala Gly Pro Gly Arg Gly Val Glu 
65                  70                  75                  80  


Leu Gly Leu Arg Ser Val Ala Leu Gly Phe Asp Asp Thr Glu Val Thr 
                85                  90                  95      


Thr Pro Met Gly Thr Ala Glu Val Ala Pro Asp Thr Ser Pro Arg Ser 
            100                 105                 110         


Gly Pro Ser Cys Trp His Arg Leu Val Gln Val Phe Gln Ser Lys Gln 
        115                 120                 125             


Phe Arg Ser Ala Lys Leu Glu Arg Leu Tyr Gln Arg Tyr Phe Phe Gln 
    130                 135                 140                 


Met Asn Gln Ser Ser Leu Thr Leu Leu Met Ala Val Leu Val Leu Leu 
145                 150                 155                 160 


Met Ala Val Leu Leu Thr Phe His Ala Ala Pro Ala Gln Pro Gln Pro 
                165                 170                 175     


Ala Tyr Val Ala Leu Leu Thr Cys Ala Ser Val Leu Phe Val Val Leu 
            180                 185                 190         


Met Val Val Cys Asn Arg His Ser Phe Arg Gln Asp Ser Met Trp Val 
        195                 200                 205             


Val Ser Tyr Val Val Leu Gly Ile Leu Ala Ala Val Gln Val Gly Gly 
    210                 215                 220                 


Ala Leu Ala Ala Asn Pro His Ser Pro Ser Ala Gly Leu Trp Cys Pro 
225                 230                 235                 240 


Val Phe Phe Val Tyr Ile Thr Tyr Thr Leu Leu Pro Ile Arg Met Arg 
                245                 250                 255     


Ala Ala Val Leu Ser Gly Leu Gly Leu Ser Thr Leu His Leu Ile Leu 
            260                 265                 270         


Ala Trp Gln Leu Asn Ser Ser Asp Pro Phe Leu Trp Lys Gln Leu Gly 
        275                 280                 285             


Ala Asn Val Val Leu Phe Leu Cys Thr Asn Ala Ile Gly Val Cys Thr 
    290                 295                 300                 


His Tyr Pro Ala Glu Val Ser Gln Arg Gln Ala Phe Gln Glu Thr Arg 
305                 310                 315                 320 


Gly Tyr Ile Gln Ala Arg Leu His Leu Gln His Glu Asn Arg Gln Gln 
                325                 330                 335     


Glu Arg Leu Leu Leu Ser Val Leu Pro Gln His Val Ala Met Glu Met 
            340                 345                 350         


Lys Glu Asp Ile Asn Thr Lys Lys Glu Asp Met Met Phe His Lys Ile 
        355                 360                 365             


Tyr Ile Gln Lys His Asp Asn Val Ser Ile Leu Phe Ala Asp Ile Glu 
    370                 375                 380                 


Gly Phe Thr Ser Leu Ala Ser Gln Cys Thr Ala Gln Glu Leu Val Met 
385                 390                 395                 400 


Thr Leu Asn Glu Leu Phe Ala Arg Phe Asp Lys Leu Ala Ala Glu Asn 
                405                 410                 415     


His Cys Leu Arg Ile Lys Ile Leu Gly Asp Cys Tyr Tyr Cys Val Ser 
            420                 425                 430         


Gly Leu Pro Glu Ala Arg Ala Asp His Ala His Cys Cys Val Glu Met 
        435                 440                 445             


Gly Val Asp Met Ile Glu Ala Ile Ser Leu Val Arg Glu Val Thr Gly 
    450                 455                 460                 


Val Asn Val Asn Met Arg Val Gly Ile His Ser Gly Arg Val His Cys 
465                 470                 475                 480 


Gly Val Leu Gly Leu Arg Lys Trp Gln Phe Asp Val Trp Ser Asn Asp 
                485                 490                 495     


Val Thr Leu Ala Asn His Met Glu Ala Gly Gly Arg Ala Gly Arg Ile 
            500                 505                 510         


His Ile Thr Arg Ala Thr Leu Gln Tyr Leu Asn Gly Asp Tyr Glu Val 
        515                 520                 525             


Glu Pro Gly Arg Gly Gly Glu Arg Asn Ala Tyr Leu Lys Glu Gln Cys 
    530                 535                 540                 


Ile Glu Thr Phe Leu Ile Leu Gly Ala Ser Gln Lys Arg Lys Glu Glu 
545                 550                 555                 560 


Lys Ala Met Leu Ala Lys Leu Gln Arg Thr Arg Ala Asn Ser Met Glu 
                565                 570                 575     


Gly Leu Met Pro Arg Trp Val Pro Asp Arg Ala Phe Ser Arg Thr Lys 
            580                 585                 590         


Asp Ser Lys Ala Phe Arg Gln Met Gly Ile Asp Asp Ser Ser Lys Asp 
        595                 600                 605             


Asn Arg Gly Ala Gln Asp Ala Leu Asn Pro Glu Asp Glu Val Asp Glu 
    610                 615                 620                 


Phe Leu Gly Arg Ala Ile Asp Ala Arg Ser Ile Asp Gln Leu Arg Lys 
625                 630                 635                 640 


Asp His Val Arg Arg Phe Leu Leu Thr Phe Gln Arg Glu Asp Leu Glu 
                645                 650                 655     


Lys Lys Tyr Ser Arg Lys Val Asp Pro Arg Phe Gly Ala Tyr Val Ala 
            660                 665                 670         


Cys Ala Leu Leu Val Phe Cys Phe Ile Cys Phe Ile Gln Leu Leu Val 
        675                 680                 685             


Phe Pro Tyr Ser Thr Leu Ile Leu Gly Ile Tyr Ala Ala Ile Phe Leu 
    690                 695                 700                 


Leu Leu Leu Val Thr Val Leu Ile Cys Ala Val Cys Ser Cys Gly Ser 
705                 710                 715                 720 


Phe Phe Pro Lys Ala Leu Gln Arg Leu Ser Arg Asn Ile Val Arg Ser 
                725                 730                 735     


Arg Val His Ser Thr Ala Val Gly Ile Phe Ser Val Leu Leu Val Phe 
            740                 745                 750         


Ile Ser Ala Ile Ala Asn Met Phe Thr Cys Asn His Thr Pro Ile Arg 
        755                 760                 765             


Thr Cys Ala Ala Arg Met Leu Asn Leu Thr Pro Ala Asp Val Thr Ala 
    770                 775                 780                 


Cys His Leu Gln Gln Leu Asn Tyr Ser Leu Gly Leu Asp Ala Pro Leu 
785                 790                 795                 800 


Cys Glu Gly Thr Ala Pro Thr Cys Ser Phe Pro Glu Tyr Phe Val Gly 
                805                 810                 815     


Asn Val Leu Leu Ser Leu Leu Ala Ser Ser Val Phe Leu His Ile Ser 
            820                 825                 830         


Ser Ile Gly Lys Leu Ala Met Thr Phe Ile Leu Gly Phe Thr Tyr Leu 
        835                 840                 845             


Val Leu Leu Leu Leu Gly Pro Pro Ala Ala Ile Phe Asp Asn Tyr Asp 
    850                 855                 860                 


Leu Leu Leu Gly Val His Gly Leu Ala Ser Ser Asn Glu Thr Phe Asp 
865                 870                 875                 880 


Gly Leu Asp Cys Pro Ala Val Gly Arg Val Ala Leu Lys Tyr Met Thr 
                885                 890                 895     


Pro Val Ile Leu Leu Val Phe Ala Leu Ala Leu Tyr Leu His Ala Gln 
            900                 905                 910         


Gln Val Glu Ser Thr Ala Arg Leu Asp Phe Leu Trp Lys Leu Gln Ala 
        915                 920                 925             


Thr Gly Glu Lys Glu Glu Met Glu Glu Leu Gln Ala Tyr Asn Arg Arg 
    930                 935                 940                 


Leu Leu His Asn Ile Leu Pro Lys Asp Val Ala Ala His Phe Leu Ala 
945                 950                 955                 960 


Arg Glu Arg Arg Asn Asp Glu Leu Tyr Tyr Gln Ser Cys Glu Cys Val 
                965                 970                 975     


Ala Val Met Phe Ala Ser Ile Ala Asn Phe Ser Glu Phe Tyr Val Glu 
            980                 985                 990         


Leu Glu Ala Asn Asn Glu Gly Val  Glu Cys Leu Arg Leu  Leu Asn Glu 
        995                 1000                 1005             


Ile Ile  Ala Asp Phe Asp Glu  Ile Ile Ser Glu Glu  Arg Phe Arg 
    1010                 1015                 1020             


Gln Leu  Glu Lys Ile Lys Thr  Ile Gly Ser Thr Tyr  Met Ala Ala 
    1025                 1030                 1035             


Ser Gly  Leu Asn Ala Ser Thr  Tyr Asp Gln Val Gly  Arg Ser His 
    1040                 1045                 1050             


Ile Thr  Ala Leu Ala Asp Tyr  Ala Met Arg Leu Met  Glu Gln Met 
    1055                 1060                 1065             


Lys His  Ile Asn Glu His Ser  Phe Asn Asn Phe Gln  Met Lys Ile 
    1070                 1075                 1080             


Gly Leu  Asn Met Gly Pro Val  Val Ala Gly Val Ile  Gly Ala Arg 
    1085                 1090                 1095             


Lys Pro  Gln Tyr Asp Ile Trp  Gly Asn Thr Val Asn  Val Ser Ser 
    1100                 1105                 1110             


Arg Met  Asp Ser Thr Gly Val  Pro Asp Arg Ile Gln  Val Thr Thr 
    1115                 1120                 1125             


Asp Leu  Tyr Gln Val Leu Ala  Ala Lys Gly Tyr Gln  Leu Glu Cys 
    1130                 1135                 1140             


Arg Gly  Val Val Lys Val Lys  Gly Lys Gly Glu Met  Thr Thr Tyr 
    1145                 1150                 1155             


Phe Leu  Asn Gly Gly Pro Ser  Ser 
    1160                 1165     


<210>  17
<211>  1166
<212>  PRT
<213>  mus musculus

<400>  17

Met Ser Trp Phe Ser Gly Leu Leu Val Pro Lys Val Asp Glu Arg Lys 
1               5                   10                  15      


Thr Ala Trp Gly Glu Arg Asn Gly Gln Lys Arg Pro Arg His Ala Asn 
            20                  25                  30          


Arg Ala Ser Gly Phe Cys Ala Pro Arg Tyr Met Ser Cys Leu Lys Asn 
        35                  40                  45              


Ala Glu Pro Pro Ser Pro Thr Pro Ala Ala His Thr Arg Cys Pro Trp 
    50                  55                  60                  


Gln Asp Glu Ala Phe Ile Arg Arg Ala Gly Pro Gly Arg Gly Val Glu 
65                  70                  75                  80  


Leu Gly Leu Arg Ser Val Ala Leu Gly Phe Asp Asp Thr Glu Val Thr 
                85                  90                  95      


Thr Pro Met Gly Thr Ala Glu Val Ala Pro Asp Thr Ser Pro Arg Ser 
            100                 105                 110         


Gly Pro Ser Cys Trp His Arg Leu Val Gln Val Phe Gln Ser Lys Gln 
        115                 120                 125             


Phe Arg Ser Ala Lys Leu Glu Arg Leu Tyr Gln Arg Tyr Phe Phe Gln 
    130                 135                 140                 


Met Asn Gln Ser Ser Leu Thr Leu Leu Met Ala Val Leu Val Leu Leu 
145                 150                 155                 160 


Met Ala Val Leu Leu Thr Phe His Ala Ala Pro Ala Gln Pro Gln Pro 
                165                 170                 175     


Ala Tyr Val Ala Leu Leu Thr Cys Ala Ser Val Leu Phe Val Val Leu 
            180                 185                 190         


Met Val Val Cys Asn Arg His Ser Phe Arg Gln Asp Ser Met Trp Val 
        195                 200                 205             


Val Ser Tyr Val Val Leu Gly Ile Leu Ala Ala Val Gln Val Gly Gly 
    210                 215                 220                 


Ala Leu Ala Ala Asn Pro His Ser Pro Ser Ala Gly Leu Trp Cys Pro 
225                 230                 235                 240 


Val Phe Phe Val Tyr Ile Thr Tyr Thr Leu Leu Pro Ile Arg Met Arg 
                245                 250                 255     


Ala Ala Val Leu Ser Gly Leu Gly Leu Ser Thr Leu His Leu Ile Leu 
            260                 265                 270         


Ala Trp Gln Leu Asn Ser Ser Asp Pro Phe Leu Trp Lys Gln Leu Gly 
        275                 280                 285             


Ala Asn Val Val Leu Phe Leu Cys Thr Asn Ala Ile Gly Val Cys Thr 
    290                 295                 300                 


His Tyr Pro Ala Glu Val Ser Gln Arg Gln Ala Phe Gln Glu Thr Arg 
305                 310                 315                 320 


Gly Tyr Ile Gln Ala Arg Leu His Leu Gln His Glu Asn Arg Gln Gln 
                325                 330                 335     


Glu Arg Leu Leu Leu Ser Val Leu Pro Gln His Val Ala Met Glu Met 
            340                 345                 350         


Lys Glu Asp Ile Asn Thr Lys Lys Glu Asp Met Met Phe His Lys Ile 
        355                 360                 365             


Tyr Ile Gln Lys His Asp Asn Val Ser Ile Leu Phe Ala Asp Ile Glu 
    370                 375                 380                 


Gly Phe Thr Ser Leu Ala Ser Gln Cys Thr Ala Gln Glu Leu Val Met 
385                 390                 395                 400 


Thr Leu Asn Glu Leu Phe Ala Arg Phe Asp Lys Leu Ala Ala Glu Asn 
                405                 410                 415     


His Cys Leu Arg Ile Lys Ile Leu Gly Ala Cys Tyr Tyr Cys Val Ser 
            420                 425                 430         


Gly Leu Pro Glu Ala Arg Ala Asp His Ala His Cys Cys Val Glu Met 
        435                 440                 445             


Gly Val Asp Met Ile Glu Ala Ile Ser Leu Val Arg Glu Val Thr Gly 
    450                 455                 460                 


Val Asn Val Asn Met Arg Val Gly Ile His Ser Gly Arg Val His Cys 
465                 470                 475                 480 


Gly Val Leu Gly Leu Arg Lys Trp Gln Phe Asp Val Trp Ser Asn Asp 
                485                 490                 495     


Val Thr Leu Ala Asn His Met Glu Ala Gly Gly Arg Ala Gly Arg Ile 
            500                 505                 510         


His Ile Thr Arg Ala Thr Leu Gln Tyr Leu Asn Gly Asp Tyr Glu Val 
        515                 520                 525             


Glu Pro Gly Arg Gly Gly Glu Arg Asn Ala Tyr Leu Lys Glu Gln Cys 
    530                 535                 540                 


Ile Glu Thr Phe Leu Ile Leu Gly Ala Ser Gln Lys Arg Lys Glu Glu 
545                 550                 555                 560 


Lys Ala Met Leu Ala Lys Leu Gln Arg Thr Arg Ala Asn Ser Met Glu 
                565                 570                 575     


Gly Leu Met Pro Arg Trp Val Pro Asp Arg Ala Phe Ser Arg Thr Lys 
            580                 585                 590         


Asp Ser Lys Ala Phe Arg Gln Met Gly Ile Asp Asp Ser Ser Lys Asp 
        595                 600                 605             


Asn Arg Gly Ala Gln Asp Ala Leu Asn Pro Glu Asp Glu Val Asp Glu 
    610                 615                 620                 


Phe Leu Gly Arg Ala Ile Asp Ala Arg Ser Ile Asp Gln Leu Arg Lys 
625                 630                 635                 640 


Asp His Val Arg Arg Phe Leu Leu Thr Phe Gln Arg Glu Asp Leu Glu 
                645                 650                 655     


Lys Lys Tyr Ser Arg Lys Val Asp Pro Arg Phe Gly Ala Tyr Val Ala 
            660                 665                 670         


Cys Ala Leu Leu Val Phe Cys Phe Ile Cys Phe Ile Gln Leu Leu Val 
        675                 680                 685             


Phe Pro Tyr Ser Thr Leu Ile Leu Gly Ile Tyr Ala Ala Ile Phe Leu 
    690                 695                 700                 


Leu Leu Leu Val Thr Val Leu Ile Cys Ala Val Cys Ser Cys Gly Ser 
705                 710                 715                 720 


Phe Phe Pro Lys Ala Leu Gln Arg Leu Ser Arg Asn Ile Val Arg Ser 
                725                 730                 735     


Arg Val His Ser Thr Ala Val Gly Ile Phe Ser Val Leu Leu Val Phe 
            740                 745                 750         


Ile Ser Ala Ile Ala Asn Met Phe Thr Cys Asn His Thr Pro Ile Arg 
        755                 760                 765             


Thr Cys Ala Ala Arg Met Leu Asn Leu Thr Pro Ala Asp Val Thr Ala 
    770                 775                 780                 


Cys His Leu Gln Gln Leu Asn Tyr Ser Leu Gly Leu Asp Ala Pro Leu 
785                 790                 795                 800 


Cys Glu Gly Thr Ala Pro Thr Cys Ser Phe Pro Glu Tyr Phe Val Gly 
                805                 810                 815     


Asn Val Leu Leu Ser Leu Leu Ala Ser Ser Val Phe Leu His Ile Ser 
            820                 825                 830         


Ser Ile Gly Lys Leu Ala Met Thr Phe Ile Leu Gly Phe Thr Tyr Leu 
        835                 840                 845             


Val Leu Leu Leu Leu Gly Pro Pro Ala Ala Ile Phe Asp Asn Tyr Asp 
    850                 855                 860                 


Leu Leu Leu Gly Val His Gly Leu Ala Ser Ser Asn Glu Thr Phe Asp 
865                 870                 875                 880 


Gly Leu Asp Cys Pro Ala Val Gly Arg Val Ala Leu Lys Tyr Met Thr 
                885                 890                 895     


Pro Val Ile Leu Leu Val Phe Ala Leu Ala Leu Tyr Leu His Ala Gln 
            900                 905                 910         


Gln Val Glu Ser Thr Ala Arg Leu Asp Phe Leu Trp Lys Leu Gln Ala 
        915                 920                 925             


Thr Gly Glu Lys Glu Glu Met Glu Glu Leu Gln Ala Tyr Asn Arg Arg 
    930                 935                 940                 


Leu Leu His Asn Ile Leu Pro Lys Asp Val Ala Ala His Phe Leu Ala 
945                 950                 955                 960 


Arg Glu Arg Arg Asn Asp Glu Leu Tyr Tyr Gln Ser Cys Glu Cys Val 
                965                 970                 975     


Ala Val Met Phe Ala Ser Ile Ala Asn Phe Ser Glu Phe Tyr Val Glu 
            980                 985                 990         


Leu Glu Ala Asn Asn Glu Gly Val  Glu Cys Leu Arg Leu  Leu Asn Glu 
        995                 1000                 1005             


Ile Ile  Ala Asp Phe Asp Glu  Ile Ile Ser Glu Glu  Arg Phe Arg 
    1010                 1015                 1020             


Gln Leu  Glu Lys Ile Lys Thr  Ile Gly Ser Thr Tyr  Met Ala Ala 
    1025                 1030                 1035             


Ser Gly  Leu Asn Ala Ser Thr  Tyr Asp Gln Val Gly  Arg Ser His 
    1040                 1045                 1050             


Ile Thr  Ala Leu Ala Asp Tyr  Ala Met Arg Leu Met  Glu Gln Met 
    1055                 1060                 1065             


Lys His  Ile Asn Glu His Ser  Phe Asn Asn Phe Gln  Met Lys Ile 
    1070                 1075                 1080             


Gly Leu  Asn Met Gly Pro Val  Val Ala Gly Val Ile  Gly Ala Arg 
    1085                 1090                 1095             


Lys Pro  Gln Tyr Asp Ile Trp  Gly Asn Thr Val Asn  Val Ser Ser 
    1100                 1105                 1110             


Arg Met  Asp Ser Thr Gly Val  Pro Asp Arg Ile Gln  Val Thr Thr 
    1115                 1120                 1125             


Asp Leu  Tyr Gln Val Leu Ala  Ala Lys Gly Tyr Gln  Leu Glu Cys 
    1130                 1135                 1140             


Arg Gly  Val Val Lys Val Lys  Gly Lys Gly Glu Met  Thr Thr Tyr 
    1145                 1150                 1155             


Phe Leu  Asn Gly Gly Pro Ser  Ser 
    1160                 1165     


