                         SEQUENCE LISTING

<110>  Anergis SA
       Kettner, et al.
 
<120>  CONTIGUOUS OVERLAPPING PEPTIDES FOR TREATMENT OF HOUSE DUST MITES

<130>  30985/47712A

<150>  61/831,961
<151>  2013-06-06

<160>  29    

<170>  PatentIn version 3.5

<210>  1
<211>  81
<212>  PRT
<213>  Dermatophagoides pteronyssinus

<400>  1

Thr Asn Ala Cys Ser Ile Asn Gly Asn Ala Pro Ala Glu Ile Asp Leu 
1               5                   10                  15      


Arg Gln Met Arg Thr Val Thr Pro Ile Arg Met Gln Gly Gly Cys Gly 
            20                  25                  30          


Ser Cys Trp Ala Phe Ser Gly Val Ala Ala Thr Glu Ser Ala Tyr Leu 
        35                  40                  45              


Ala Tyr Arg Asn Gln Ser Leu Asp Leu Ala Glu Gln Glu Leu Val Asp 
    50                  55                  60                  


Cys Ala Ser Gln His Gly Cys His Gly Asp Thr Ile Pro Arg Gly Ile 
65                  70                  75                  80  


Glu 
    


<210>  2
<211>  86
<212>  PRT
<213>  Dermatophagoides pteronyssinus

<400>  2

Ser Gln His Gly Cys His Gly Asp Thr Ile Pro Arg Gly Ile Glu Tyr 
1               5                   10                  15      


Ile Gln His Asn Gly Val Val Gln Glu Ser Tyr Tyr Arg Tyr Val Ala 
            20                  25                  30          


Arg Glu Gln Ser Cys Arg Arg Pro Asn Ala Gln Arg Phe Gly Ile Ser 
        35                  40                  45              


Asn Tyr Cys Gln Ile Tyr Pro Pro Asn Val Asn Lys Ile Arg Glu Ala 
    50                  55                  60                  


Leu Ala Gln Thr His Ser Ala Ile Ala Val Ile Ile Gly Ile Lys Asp 
65                  70                  75                  80  


Leu Asp Ala Phe Arg His 
                85      


<210>  3
<211>  86
<212>  PRT
<213>  Dermatophagoides pteronyssinus

<400>  3

Ala Ile Ala Val Ile Ile Gly Ile Lys Asp Leu Asp Ala Phe Arg His 
1               5                   10                  15      


Tyr Asp Gly Arg Thr Ile Ile Gln Arg Asp Asn Gly Tyr Gln Pro Asn 
            20                  25                  30          


Tyr His Ala Val Asn Ile Val Gly Tyr Ser Asn Ala Gln Gly Val Asp 
        35                  40                  45              


Tyr Trp Ile Val Arg Asn Ser Trp Asp Thr Asn Trp Gly Asp Asn Gly 
    50                  55                  60                  


Tyr Gly Tyr Phe Ala Ala Asn Ile Asp Leu Met Met Ile Glu Glu Tyr 
65                  70                  75                  80  


Pro Tyr Val Val Ile Leu 
                85      


<210>  4
<211>  66
<212>  PRT
<213>  Dermatophagoides pteronyssinus

<400>  4

Thr Asn Ala Cys Ser Ile Asn Gly Asn Ala Pro Ala Glu Ile Asp Leu 
1               5                   10                  15      


Arg Gln Met Arg Thr Val Thr Pro Ile Arg Met Gln Gly Gly Cys Gly 
            20                  25                  30          


Ser Cys Trp Ala Phe Ser Gly Val Ala Ala Thr Glu Ser Ala Tyr Leu 
        35                  40                  45              


Ala Tyr Arg Asn Gln Ser Leu Asp Leu Ala Glu Gln Glu Leu Val Asp 
    50                  55                  60                  


Cys Ala 
65      


<210>  5
<211>  73
<212>  PRT
<213>  Dermatophagoides pteronyssinus

<400>  5

Leu Ala Glu Gln Glu Leu Val Asp Cys Ala Ser Gln His Gly Cys His 
1               5                   10                  15      


Gly Asp Thr Ile Pro Arg Gly Ile Glu Tyr Ile Gln His Asn Gly Val 
            20                  25                  30          


Val Gln Glu Ser Tyr Tyr Arg Tyr Val Ala Arg Glu Gln Ser Cys Arg 
        35                  40                  45              


Arg Pro Asn Ala Gln Arg Phe Gly Ile Ser Asn Tyr Cys Gln Ile Tyr 
    50                  55                  60                  


Pro Pro Asn Val Asn Lys Ile Arg Glu 
65                  70              


<210>  6
<211>  73
<212>  PRT
<213>  Dermatophagoides pteronyssinus

<400>  6

Pro Asn Val Asn Lys Ile Arg Glu Ala Leu Ala Gln Thr His Ser Ala 
1               5                   10                  15      


Ile Ala Val Ile Ile Gly Ile Lys Asp Leu Asp Ala Phe Arg His Tyr 
            20                  25                  30          


Asp Gly Arg Thr Ile Ile Gln Arg Asp Asn Gly Tyr Gln Pro Asn Tyr 
        35                  40                  45              


His Ala Val Asn Ile Val Gly Tyr Ser Asn Ala Gln Gly Val Asp Tyr 
    50                  55                  60                  


Trp Ile Val Arg Asn Ser Trp Asp Thr 
65                  70              


<210>  7
<211>  40
<212>  PRT
<213>  Dermatophagoides pteronyssinus

<400>  7

Val Asp Tyr Trp Ile Val Arg Asn Ser Trp Asp Thr Asn Trp Gly Asp 
1               5                   10                  15      


Asn Gly Tyr Gly Tyr Phe Ala Ala Asn Ile Asp Leu Met Met Ile Glu 
            20                  25                  30          


Glu Tyr Pro Tyr Val Val Ile Leu 
        35                  40  


<210>  8
<211>  70
<212>  PRT
<213>  Dermatophagoides pteronyssinus

<400>  8

Thr Asn Ala Cys Ser Ile Asn Gly Asn Ala Pro Ala Glu Ile Asp Leu 
1               5                   10                  15      


Arg Gln Met Arg Thr Val Thr Pro Ile Arg Met Gln Gly Gly Cys Gly 
            20                  25                  30          


Ser Cys Trp Ala Phe Ser Gly Val Ala Ala Thr Glu Ser Ala Tyr Leu 
        35                  40                  45              


Ala Tyr Arg Asn Gln Ser Leu Asp Leu Ala Glu Gln Glu Leu Val Asp 
    50                  55                  60                  


Cys Ala Ser Gln His Gly 
65                  70  


<210>  9
<211>  64
<212>  PRT
<213>  Dermatophagoides pteronyssinus

<400>  9

Ala Ser Gln His Gly Cys His Gly Asp Thr Ile Pro Arg Gly Ile Glu 
1               5                   10                  15      


Tyr Ile Gln His Asn Gly Val Val Gln Glu Ser Tyr Tyr Arg Tyr Val 
            20                  25                  30          


Ala Arg Glu Gln Ser Cys Arg Arg Pro Asn Ala Gln Arg Phe Gly Ile 
        35                  40                  45              


Ser Asn Tyr Cys Gln Ile Tyr Pro Pro Asn Val Asn Lys Ile Arg Glu 
    50                  55                  60                  


<210>  10
<211>  63
<212>  PRT
<213>  Dermatophagoides pteronyssinus

<400>  10

Pro Asn Val Asn Lys Ile Arg Glu Ala Leu Ala Gln Thr His Ser Ala 
1               5                   10                  15      


Ile Ala Val Ile Ile Gly Ile Lys Asp Leu Asp Ala Phe Arg His Tyr 
            20                  25                  30          


Asp Gly Arg Thr Ile Ile Gln Arg Asp Asn Gly Tyr Gln Pro Asn Tyr 
        35                  40                  45              


His Ala Val Asn Ile Val Gly Tyr Ser Asn Ala Gln Gly Val Asp 
    50                  55                  60              


<210>  11
<211>  43
<212>  PRT
<213>  Dermatophagoides pteronyssinus

<400>  11

Ala Gln Gly Val Asp Tyr Trp Ile Val Arg Asn Ser Trp Asp Thr Asn 
1               5                   10                  15      


Trp Gly Asp Asn Gly Tyr Gly Tyr Phe Ala Ala Asn Ile Asp Leu Met 
            20                  25                  30          


Met Ile Glu Glu Tyr Pro Tyr Val Val Ile Leu 
        35                  40              


<210>  12
<211>  37
<212>  PRT
<213>  Dermatophagoides pteronyssinus

<400>  12

Ala Ser Gln His Gly Cys His Gly Asp Thr Ile Pro Arg Gly Ile Glu 
1               5                   10                  15      


Tyr Ile Gln His Asn Gly Val Val Gln Glu Ser Tyr Tyr Arg Tyr Val 
            20                  25                  30          


Ala Arg Glu Gln Ser 
        35          


<210>  13
<211>  35
<212>  PRT
<213>  Dermatophagoides pteronyssinus

<400>  13

Arg Tyr Val Ala Arg Glu Gln Ser Cys Arg Arg Pro Asn Ala Gln Arg 
1               5                   10                  15      


Phe Gly Ile Ser Asn Tyr Cys Gln Ile Tyr Pro Pro Asn Val Asn Lys 
            20                  25                  30          


Ile Arg Glu 
        35  


<210>  14
<211>  35
<212>  PRT
<213>  Dermatophagoides pteronyssinus

<400>  14

Pro Asn Val Asn Lys Ile Arg Glu Ala Leu Ala Gln Thr His Ser Ala 
1               5                   10                  15      


Ile Ala Val Ile Ile Gly Ile Lys Asp Leu Asp Ala Phe Arg His Tyr 
            20                  25                  30          


Asp Gly Arg 
        35  


<210>  15
<211>  34
<212>  PRT
<213>  Dermatophagoides pteronyssinus

<400>  15

Arg His Tyr Asp Gly Arg Thr Ile Ile Gln Arg Asp Asn Gly Tyr Gln 
1               5                   10                  15      


Pro Asn Tyr His Ala Val Asn Ile Val Gly Tyr Ser Asn Ala Gln Gly 
            20                  25                  30          


Val Asp 
        


<210>  16
<211>  72
<212>  PRT
<213>  Dermatophagoides pteronyssinus

<400>  16

Asp Gln Val Asp Val Lys Asp Cys Ala Asn His Glu Ile Lys Lys Val 
1               5                   10                  15      


Leu Val Pro Gly Cys His Gly Ser Glu Pro Cys Ile Ile His Arg Gly 
            20                  25                  30          


Lys Pro Phe Gln Leu Glu Ala Val Phe Glu Ala Asn Gln Asn Thr Lys 
        35                  40                  45              


Thr Ala Lys Ile Glu Ile Lys Ala Ser Ile Asp Gly Leu Glu Val Asp 
    50                  55                  60                  


Val Pro Gly Ile Asp Pro Asn Ala 
65                  70          


<210>  17
<211>  73
<212>  PRT
<213>  Dermatophagoides pteronyssinus

<400>  17

Ser Ile Asp Gly Leu Glu Val Asp Val Pro Gly Ile Asp Pro Asn Ala 
1               5                   10                  15      


Cys His Tyr Met Lys Cys Pro Leu Val Lys Gly Gln Gln Tyr Asp Ile 
            20                  25                  30          


Lys Tyr Thr Trp Asn Val Pro Lys Ile Ala Pro Lys Ser Glu Asn Val 
        35                  40                  45              


Val Val Thr Val Lys Val Met Gly Asp Asp Gly Val Leu Ala Cys Ala 
    50                  55                  60                  


Ile Ala Thr His Ala Lys Ile Arg Asp 
65                  70              


<210>  18
<211>  25
<212>  PRT
<213>  Dermatophagoides pteronyssinus

<400>  18

Asp Gln Val Asp Val Lys Asp Cys Ala Asn His Glu Ile Lys Lys Val 
1               5                   10                  15      


Leu Val Pro Gly Cys His Gly Ser Glu 
            20                  25  


<210>  19
<211>  56
<212>  PRT
<213>  Dermatophagoides pteronyssinus

<400>  19

His Gly Ser Glu Pro Cys Ile Ile His Arg Gly Lys Pro Phe Gln Leu 
1               5                   10                  15      


Glu Ala Leu Phe Glu Ala Asn Gln Asn Ser Lys Thr Ala Lys Ile Glu 
            20                  25                  30          


Ile Lys Ala Ser Ile Asp Gly Leu Glu Val Asp Val Pro Gly Ile Asp 
        35                  40                  45              


Pro Asn Ala Cys His Tyr Met Lys 
    50                  55      


<210>  20
<211>  56
<212>  PRT
<213>  Dermatophagoides pteronyssinus

<400>  20

His Tyr Met Lys Cys Pro Leu Val Lys Gly Gln Gln Tyr Asp Ile Lys 
1               5                   10                  15      


Tyr Thr Trp Asn Val Pro Lys Ile Ala Pro Lys Ser Glu Asn Val Val 
            20                  25                  30          


Val Thr Val Lys Val Leu Gly Asp Asn Gly Val Leu Ala Cys Ala Ile 
        35                  40                  45              


Ala Thr His Ala Lys Ile Arg Asp 
    50                  55      


<210>  21
<211>  31
<212>  PRT
<213>  Dermatophagoides pteronyssinus

<400>  21

Asp Gln Val Asp Val Lys Asp Cys Ala Asn His Glu Ile Lys Lys Val 
1               5                   10                  15      


Leu Val Pro Gly Cys His Gly Ser Glu Pro Cys Ile Ile His Arg 
            20                  25                  30      


<210>  22
<211>  75
<212>  PRT
<213>  Dermatophagoides pteronyssinus

<400>  22

Ser Glu Pro Cys Ile Ile His Arg Gly Lys Pro Phe Gln Leu Glu Ala 
1               5                   10                  15      


Leu Phe Glu Ala Asn Gln Asn Ser Lys Thr Ala Lys Ile Glu Ile Lys 
            20                  25                  30          


Ala Ser Ile Asp Gly Leu Glu Val Asp Val Pro Gly Ile Asp Pro Asn 
        35                  40                  45              


Ala Cys His Tyr Met Lys Cys Pro Leu Val Lys Gly Gln Gln Tyr Asp 
    50                  55                  60                  


Ile Lys Tyr Thr Trp Asn Val Pro Lys Ile Ala 
65                  70                  75  


<210>  23
<211>  41
<212>  PRT
<213>  Dermatophagoides pteronyssinus

<400>  23

Lys Tyr Thr Trp Asn Val Pro Lys Ile Ala Pro Lys Ser Glu Asn Val 
1               5                   10                  15      


Val Val Thr Val Lys Val Leu Gly Asp Asn Gly Val Leu Ala Cys Ala 
            20                  25                  30          


Ile Ala Thr His Ala Lys Ile Arg Asp 
        35                  40      


<210>  24
<211>  57
<212>  PRT
<213>  Dermatophagoides pteronyssinus

<400>  24

Ser Ile Asp Gly Leu Glu Val Asp Val Pro Gly Ile Asp Pro Asn Ala 
1               5                   10                  15      


Cys His Tyr Met Lys Cys Pro Leu Val Lys Gly Gln Gln Tyr Asp Ile 
            20                  25                  30          


Lys Tyr Thr Trp Asn Val Pro Lys Ile Ala Pro Lys Ser Glu Asn Val 
        35                  40                  45              


Val Val Thr Val Lys Val Leu Gly Asp 
    50                  55          


<210>  25
<211>  21
<212>  PRT
<213>  Dermatophagoides pteronyssinus

<400>  25

Lys Val Leu Gly Asp Asn Gly Val Leu Ala Cys Ala Ile Ala Thr His 
1               5                   10                  15      


Ala Lys Ile Arg Asp 
            20      


<210>  26
<211>  32
<212>  PRT
<213>  Dermatophagoides pteronyssinus

<400>  26

Ala Arg Glu Gln Ser Cys Arg Arg Pro Asn Ala Gln Arg Phe Gly Ile 
1               5                   10                  15      


Ser Asn Tyr Cys Gln Ile Tyr Pro Pro Asn Val Asn Lys Ile Arg Glu 
            20                  25                  30          


<210>  27
<211>  320
<212>  PRT
<213>  Dermatophagoides pteronyssinus

<400>  27

Met Lys Ile Val Leu Ala Ile Ala Ser Leu Leu Ala Leu Ser Ala Val 
1               5                   10                  15      


Tyr Ala Arg Pro Ser Ser Ile Lys Thr Phe Glu Glu Tyr Lys Lys Ala 
            20                  25                  30          


Phe Asn Lys Ser Tyr Ala Thr Phe Glu Asp Glu Glu Ala Ala Arg Lys 
        35                  40                  45              


Asn Phe Leu Glu Ser Val Lys Tyr Val Gln Ser Asn Gly Gly Ala Ile 
    50                  55                  60                  


Asn His Leu Ser Asp Leu Ser Leu Asp Glu Phe Lys Asn Arg Phe Leu 
65                  70                  75                  80  


Met Ser Ala Glu Ala Phe Glu His Leu Lys Thr Gln Phe Asp Leu Asn 
                85                  90                  95      


Ala Glu Thr Asn Ala Cys Ser Ile Asn Gly Asn Ala Pro Ala Glu Ile 
            100                 105                 110         


Asp Leu Arg Gln Met Arg Thr Val Thr Pro Ile Arg Met Gln Gly Gly 
        115                 120                 125             


Cys Gly Ser Cys Trp Ala Phe Ser Gly Val Ala Ala Thr Glu Ser Ala 
    130                 135                 140                 


Tyr Leu Ala Tyr Arg Asn Gln Ser Leu Asp Leu Ala Glu Gln Glu Leu 
145                 150                 155                 160 


Val Asp Cys Ala Ser Gln His Gly Cys His Gly Asp Thr Ile Pro Arg 
                165                 170                 175     


Gly Ile Glu Tyr Ile Gln His Asn Gly Val Val Gln Glu Ser Tyr Tyr 
            180                 185                 190         


Arg Tyr Val Ala Arg Glu Gln Ser Cys Arg Arg Pro Asn Ala Gln Arg 
        195                 200                 205             


Phe Gly Ile Ser Asn Tyr Cys Gln Ile Tyr Pro Pro Asn Val Asn Lys 
    210                 215                 220                 


Ile Arg Glu Ala Leu Ala Gln Thr His Ser Ala Ile Ala Val Ile Ile 
225                 230                 235                 240 


Gly Ile Lys Asp Leu Asp Ala Phe Arg His Tyr Asp Gly Arg Thr Ile 
                245                 250                 255     


Ile Gln Arg Asp Asn Gly Tyr Gln Pro Asn Tyr His Ala Val Asn Ile 
            260                 265                 270         


Val Gly Tyr Ser Asn Ala Gln Gly Val Asp Tyr Trp Ile Val Arg Asn 
        275                 280                 285             


Ser Trp Asp Thr Asn Trp Gly Asp Asn Gly Tyr Gly Tyr Phe Ala Ala 
    290                 295                 300                 


Asn Ile Asp Leu Met Met Ile Glu Glu Tyr Pro Tyr Val Val Ile Leu 
305                 310                 315                 320 


<210>  28
<211>  129
<212>  PRT
<213>  Dermatophagoides pteronyssinus

<400>  28

Asp Gln Val Asp Val Lys Asp Cys Ala Asn His Glu Ile Lys Lys Val 
1               5                   10                  15      


Leu Val Pro Gly Cys His Gly Ser Glu Pro Cys Ile Ile His Arg Gly 
            20                  25                  30          


Lys Pro Phe Gln Leu Glu Ala Leu Phe Glu Ala Asn Gln Asn Ser Lys 
        35                  40                  45              


Thr Ala Lys Ile Glu Ile Lys Ala Ser Ile Asp Gly Leu Glu Val Asp 
    50                  55                  60                  


Val Pro Gly Ile Asp Pro Asn Ala Cys His Tyr Met Lys Cys Pro Leu 
65                  70                  75                  80  


Val Lys Gly Gln Gln Tyr Asp Ile Lys Tyr Thr Trp Asn Val Pro Lys 
                85                  90                  95      


Ile Ala Pro Lys Ser Glu Asn Val Val Val Thr Val Lys Val Leu Gly 
            100                 105                 110         


Asp Asn Gly Val Leu Ala Cys Ala Ile Ala Thr His Ala Lys Ile Arg 
        115                 120                 125             


Asp 
    


<210>  29
<211>  146
<212>  PRT
<213>  Dermatophagoides pteronyssinus

<400>  29

Met Met Tyr Lys Ile Leu Cys Leu Ser Leu Leu Val Ala Ala Val Ala 
1               5                   10                  15      


Arg Asp Gln Val Asp Val Lys Asp Cys Ala Asn His Glu Ile Lys Lys 
            20                  25                  30          


Val Leu Val Pro Gly Cys His Gly Ser Glu Pro Cys Ile Ile His Arg 
        35                  40                  45              


Gly Lys Pro Phe Gln Leu Glu Ala Val Phe Glu Ala Asn Gln Asn Thr 
    50                  55                  60                  


Lys Thr Ala Lys Ile Glu Ile Lys Ala Ser Ile Asp Gly Leu Glu Val 
65                  70                  75                  80  


Asp Val Pro Gly Ile Asp Pro Asn Ala Cys His Tyr Met Lys Cys Pro 
                85                  90                  95      


Leu Val Lys Gly Gln Gln Tyr Asp Ile Lys Tyr Thr Trp Asn Val Pro 
            100                 105                 110         


Lys Ile Ala Pro Lys Ser Glu Asn Val Val Val Thr Val Lys Val Met 
        115                 120                 125             


Gly Asp Asp Gly Val Leu Ala Cys Ala Ile Ala Thr His Ala Lys Ile 
    130                 135                 140                 


Arg Asp 
145     


