                         LISTA DE SECUENCIAS

<110>  Universidad de Granada
 
<120>  Construcciones proteicas de hepta-repeticiones N-terminales (HRN) de gp41  


<130>  IPR-456

<160>  16    

<170>  PatentIn version 3.5

<210>  1
<211>  52
<212>  PRT
<213>  Secuencia Artificial

<220>
<223>  secuencia WT de la region NHR de gp41


<220>
<221>  peptido
<222>  (30)..(81)
<223>  secuencia WT de la region NHR de gp41

<400>  1

Ala Arg Gln Leu Leu Ser Gly Ile Val Gln Gln Gln Asn Asn Leu Leu 
30                  35                  40                  45      


Arg Ala Ile Glu Ala Gln Gln His Leu Leu Gln Leu Thr Val Trp Gly 
                50                  55                  60          


Ile Lys Gln Leu Gln Ala Arg Ile Leu Ala Val Glu Arg Tyr Leu Lys 
            65                  70                  75              


Asp Gln Gln Leu 
        80          


<210>  2
<211>  52
<212>  PRT
<213>  Secuencia Artificial

<220>
<223>  secuencia WT inversa de la region NHR de gp41


<220>
<221>  peptido
<222>  (30)..(81)
<223>  secuencia WT inversa de la region NHR de gp41

<400>  2

Leu Gln Gln Asp Lys Leu Tyr Arg Glu Val Ala Leu Ile Arg Ala Gln 
30                  35                  40                  45      


Leu Gln Lys Ile Gly Trp Val Thr Leu Gln Leu Leu His Gln Gln Ala 
                50                  55                  60          


Glu Ile Ala Arg Leu Leu Asn Asn Gln Gln Gln Val Ile Gly Ser Leu 
            65                  70                  75              


Leu Gln Arg Ala 
        80          


<210>  3
<211>  52
<212>  PRT
<213>  Secuencia Artificial

<220>
<223>  helice 1 de covNHR3


<220>
<221>  peptido
<222>  (30)..(81)
<223>  helice 1 de covNHR3

<400>  3

Ala Arg Gln Glu Leu Ser Gly Ile Glu Gln Lys Gln Asn Asn Leu Leu 
30                  35                  40                  45      


Arg Ala Ile Glu Ala Gln Gln His Leu Leu Gln Leu Thr Val Trp Gly 
                50                  55                  60          


Ile Lys Gln Leu Gln Ala Arg Ile Leu Ala Val Glu Arg Tyr Leu Lys 
            65                  70                  75              


Asp Gln Gln Leu 
        80          


<210>  4
<211>  51
<212>  PRT
<213>  Secuencia Artificial

<220>
<223>  helice 2 de covNHR3


<220>
<221>  peptido
<222>  (30)..(80)
<223>  helice 2 de covNHR3

<400>  4

Pro Gln Gln Asp Lys Leu Tyr Arg Glu Val Ala Leu Ile Arg Ala Gln 
30                  35                  40                  45      


Leu Gln Lys Ile Gly Trp Val Thr Leu Gln Leu Leu His Gln Gln Ala 
                50                  55                  60          


Glu Ile Ala Arg Leu Leu Asn Asn Gln Glu Gln Glu Ile Gly Ser Leu 
            65                  70                  75              


Lys Gln Arg 
        80      


<210>  5
<211>  50
<212>  PRT
<213>  Secuencia Artificial

<220>
<223>  helice 3 de covNHR3

<220>
<221>  peptido
<222>  (32)..(81)
<223>  helice 3 de covNHR3

<400>  5

Pro Leu Leu Ser Gly Ile Asp Gln Arg Gln Asn Asn Leu Lys Arg Ala 
32          35                  40                  45      


Ile Glu Ala Gln Gln His Leu Leu Gln Leu Thr Val Trp Gly Ile Lys 
        50                  55                  60          


Gln Leu Gln Ala Arg Ile Leu Ala Val Glu Arg Tyr Leu Lys Asp Gln 
    65                  70                  75              


Gln Leu 
80  


<210>  6
<211>  162
<212>  PRT
<213>  Secuencia Artificial

<220>
<223>  covNHR2


<220>
<221>  peptido
<222>  (1)..(162)
<223>  covNHR2

<400>  6

Met Ala Arg Gln Glu Leu Ser Gly Ile Glu Gln Lys Gln Asn Asn Leu 
1               5                   10                  15      


Leu Arg Ala Ile Glu Ala Gln Gln His Leu Leu Gln Leu Thr Val Trp 
            20                  25                  30          


Gly Ile Lys Gln Leu Gln Ala Arg Ile Leu Ala Val Glu Arg Tyr Leu 
        35                  40                  45              


Lys Asp Gln Gln Leu Gly Lys Ala Asp Pro Gln Gln Asp Lys Leu Tyr 
    50                  55                  60                  


Arg Glu Val Ala Leu Ile Arg Ala Gln Leu Gln Lys Ile Gly Trp Val 
65                  70                  75                  80  


Thr Leu Gln Leu Leu His Gln Gln Ala Glu Ile Ala Arg Leu Leu Asn 
                85                  90                  95      


Asn Gln Glu Gln Glu Ile Gly Ser Leu Lys Gln Arg Gly Ile Leu Asp 
            100                 105                 110         


Pro Leu Leu Ser Gly Ile Asp Gln Arg Gln Asn Asn Leu Lys Arg Ala 
        115                 120                 125             


Ile Glu Ala Gln Gln His Leu Leu Gln Leu Thr Val Trp Gly Ile Lys 
    130                 135                 140                 


Gln Leu Gln Ala Arg Ile Leu Ala Val Glu Arg Tyr Leu Lys Asp Gln 
145                 150                 155                 160 


Gln Leu 
        


<210>  7
<211>  164
<212>  PRT
<213>  Secuencia Artificial

<220>
<223>  covNHR3


<220>
<221>  peptido
<222>  (1)..(164)
<223>  covNHR3

<400>  7

Met Ala Arg Gln Glu Leu Ser Gly Ile Glu Gln Lys Gln Asn Asn Leu 
1               5                   10                  15      


Leu Arg Ala Ile Glu Ala Gln Gln His Leu Leu Gln Leu Thr Val Trp 
            20                  25                  30          


Gly Ile Lys Gln Leu Gln Ala Arg Ile Leu Ala Val Glu Arg Tyr Leu 
        35                  40                  45              


Lys Asp Gln Gln Leu Gly Lys Gly Asn Gln Pro Gln Gln Asp Lys Leu 
    50                  55                  60                  


Tyr Arg Glu Val Ala Leu Ile Arg Ala Gln Leu Gln Lys Ile Gly Trp 
65                  70                  75                  80  


Val Thr Leu Gln Leu Leu His Gln Gln Ala Glu Ile Ala Arg Leu Leu 
                85                  90                  95      


Asn Asn Gln Glu Gln Glu Ile Gly Ser Leu Lys Gln Arg Gly Leu Ile 
            100                 105                 110         


Asp Gly Pro Leu Leu Ser Gly Ile Asp Gln Arg Gln Asn Asn Leu Lys 
        115                 120                 125             


Arg Ala Ile Glu Ala Gln Gln His Leu Leu Gln Leu Thr Val Trp Gly 
    130                 135                 140                 


Ile Lys Gln Leu Gln Ala Arg Ile Leu Ala Val Glu Arg Tyr Leu Lys 
145                 150                 155                 160 


Asp Gln Gln Leu 
                


<210>  8
<211>  164
<212>  PRT
<213>  Secuencia Artificial

<220>
<223>  covNHR3-A


<220>
<221>  peptido
<222>  (1)..(164)
<223>  covNHR3-A

<400>  8

Met Ala Arg Gln Glu Leu Ser Gly Ile Glu Gln Lys Gln Asn Asn Leu 
1               5                   10                  15      


Leu Arg Ala Ile Glu Ala Gln Gln His Leu Leu Gln Leu Thr Val Trp 
            20                  25                  30          


Lys Ile Lys Gln Leu Gln Ala Arg Ile Leu Ala Val Glu Arg Tyr Leu 
        35                  40                  45              


Lys Asp Gln Gln Leu Gly Lys Gly Asn Gln Pro Gln Gln Asp Lys Leu 
    50                  55                  60                  


Tyr Arg Glu Val Ala Leu Ile Arg Ala Gln Leu Gln Lys Ile Glu Trp 
65                  70                  75                  80  


Glu Thr Leu Gln Leu Leu His Gln Gln Ala Glu Ile Ala Arg Leu Leu 
                85                  90                  95      


Asn Asn Gln Glu Gln Glu Ile Gly Ser Leu Lys Gln Arg Gly Leu Ile 
            100                 105                 110         


Asp Gly Pro Leu Leu Ser Gly Ile Asp Gln Arg Gln Asn Asn Leu Lys 
        115                 120                 125             


Arg Ala Ile Glu Ala Gln Gln His Leu Leu Gln Leu Thr Val Trp Gly 
    130                 135                 140                 


Ile Lys Gln Leu Gln Ala Arg Ile Leu Ala Val Glu Arg Tyr Leu Lys 
145                 150                 155                 160 


Asp Gln Gln Leu 
                


<210>  9
<211>  164
<212>  PRT
<213>  Secuencia Artificial

<220>
<223>  covNHR3-AC


<220>
<221>  peptido
<222>  (1)..(164)
<223>  covNHR3-AC

<400>  9

Met Ala Arg Gln Glu Leu Ser Gly Ile Glu Gln Lys Gln Asn Asn Leu 
1               5                   10                  15      


Leu Arg Ala Ile Glu Ala Gln Gln His Leu Leu Gln Leu Thr Val Ser 
            20                  25                  30          


Lys Ile Lys Gln Leu Gln Ala Arg Ile Leu Ala Val Glu Arg Tyr Leu 
        35                  40                  45              


Lys Asp Gln Gln Leu Gly Lys Gly Asn Gln Pro Gln Gln Asp Lys Leu 
    50                  55                  60                  


Tyr Arg Glu Val Ala Leu Ile Arg Ala Gln Leu Gln Lys Ile Glu Ser 
65                  70                  75                  80  


Glu Thr Leu Gln Leu Leu His Gln Gln Ala Glu Ile Ala Arg Leu Leu 
                85                  90                  95      


Asn Asn Gln Glu Gln Glu Ile Gly Ser Leu Lys Gln Arg Gly Leu Ile 
            100                 105                 110         


Asp Gly Pro Leu Leu Ser Gly Ile Asp Gln Arg Gln Asn Asn Leu Lys 
        115                 120                 125             


Arg Ala Ile Glu Ala Gln Gln His Leu Leu Gln Leu Thr Val Trp Gly 
    130                 135                 140                 


Ile Lys Gln Leu Gln Ala Arg Ile Leu Ala Val Glu Arg Tyr Leu Lys 
145                 150                 155                 160 


Asp Gln Gln Leu 
                


<210>  10
<211>  164
<212>  PRT
<213>  Secuencia Artificial

<220>
<223>  covNHR3-B


<220>
<221>  peptido
<222>  (1)..(164)
<223>  covNHR3-B

<400>  10

Met Ala Arg Gln Glu Leu Ser Gly Ile Glu Gln Lys Gln Asn Asn Leu 
1               5                   10                  15      


Leu Arg Gln Ile Glu Ala Gln Gln His Leu Leu Gln Leu Thr Val Trp 
            20                  25                  30          


Gly Ile Lys Gln Leu Gln Ala Arg Ile Leu Ala Val Glu Arg Tyr Leu 
        35                  40                  45              


Lys Asp Gln Gln Leu Gly Lys Gly Asn Gln Pro Gln Gln Asp Lys Leu 
    50                  55                  60                  


Tyr Arg Glu Val Ala Leu Ile Arg Ala Gln Leu Gln Lys Ile Gly Trp 
65                  70                  75                  80  


Val Thr Leu Gln Leu Leu His Gln Gln Ala Glu Ile Glu Arg Glu Leu 
                85                  90                  95      


Asn Asn Gln Glu Gln Glu Ile Gly Ser Leu Lys Gln Arg Gly Leu Ile 
            100                 105                 110         


Asp Gly Pro Leu Leu Ser Gly Ile Asp Gln Arg Gln Asn Asn Leu Lys 
        115                 120                 125             


Arg Ala Ile Glu Ala Gln Lys His Leu Leu Gln Leu Thr Val Trp Gly 
    130                 135                 140                 


Ile Lys Gln Leu Gln Ala Arg Ile Leu Ala Val Glu Arg Tyr Leu Lys 
145                 150                 155                 160 


Asp Gln Gln Leu 
                


<210>  11
<211>  164
<212>  PRT
<213>  Secuencia Artificial

<220>
<223>  covNHR3-AB


<220>
<221>  peptido
<222>  (1)..(164)
<223>  covNHR3-AB

<400>  11

Met Ala Arg Gln Glu Leu Ser Gly Ile Glu Gln Lys Gln Asn Asn Leu 
1               5                   10                  15      


Leu Arg Gln Ile Glu Ala Gln Gln His Leu Leu Gln Leu Thr Val Trp 
            20                  25                  30          


Lys Ile Lys Gln Leu Gln Ala Arg Ile Leu Ala Val Glu Arg Tyr Leu 
        35                  40                  45              


Lys Asp Gln Gln Leu Gly Lys Gly Asn Gln Pro Gln Gln Asp Lys Leu 
    50                  55                  60                  


Tyr Arg Glu Val Ala Leu Ile Arg Ala Gln Leu Gln Lys Ile Glu Trp 
65                  70                  75                  80  


Glu Thr Leu Gln Leu Leu His Gln Gln Ala Glu Ile Glu Arg Glu Leu 
                85                  90                  95      


Asn Asn Gln Glu Gln Glu Ile Gly Ser Leu Lys Gln Arg Gly Leu Ile 
            100                 105                 110         


Asp Gly Pro Leu Leu Ser Gly Ile Asp Gln Arg Gln Asn Asn Leu Lys 
        115                 120                 125             


Arg Ala Ile Glu Ala Gln Lys His Leu Leu Gln Leu Thr Val Trp Gly 
    130                 135                 140                 


Ile Lys Gln Leu Gln Ala Arg Ile Leu Ala Val Glu Arg Tyr Leu Lys 
145                 150                 155                 160 


Asp Gln Gln Leu 
                


<210>  12
<211>  164
<212>  PRT
<213>  Secuencia Artificial

<220>
<223>  covNHR3-ABC


<220>
<221>  peptido
<222>  (1)..(164)
<223>  covNHR3-ABC

<400>  12

Met Ala Arg Gln Glu Leu Ser Gly Ile Glu Gln Lys Gln Asn Asn Leu 
1               5                   10                  15      


Leu Arg Gln Ile Glu Ala Gln Gln His Leu Leu Gln Leu Thr Val Ser 
            20                  25                  30          


Lys Ile Lys Gln Leu Gln Ala Arg Ile Leu Ala Val Glu Arg Tyr Leu 
        35                  40                  45              


Lys Asp Gln Gln Leu Gly Lys Gly Asn Gln Pro Gln Gln Asp Lys Leu 
    50                  55                  60                  


Tyr Arg Glu Val Ala Leu Ile Arg Ala Gln Leu Gln Lys Ile Glu Ser 
65                  70                  75                  80  


Glu Thr Leu Gln Leu Leu His Gln Gln Ala Glu Ile Glu Arg Glu Leu 
                85                  90                  95      


Asn Asn Gln Glu Gln Glu Ile Gly Ser Leu Lys Gln Arg Gly Leu Ile 
            100                 105                 110         


Asp Gly Pro Leu Leu Ser Gly Ile Asp Gln Arg Gln Asn Asn Leu Lys 
        115                 120                 125             


Arg Ala Ile Glu Ala Gln Lys His Leu Leu Gln Leu Thr Val Trp Gly 
    130                 135                 140                 


Ile Lys Gln Leu Gln Ala Arg Ile Leu Ala Val Glu Arg Tyr Leu Lys 
145                 150                 155                 160 


Asp Gln Gln Leu 
                


<210>  13
<211>  36
<212>  PRT
<213>  Secuencia Artificial

<220>
<223>  CHR peptido T20


<220>
<221>  peptido
<222>  (127)..(162)
<223>  CHR peptido T20

<400>  13

Tyr Thr Ser Leu Ile His Ser Leu Ile Glu Glu Ser Gln Asn Gln Gln 
127         130                 135                 140      


Glu Lys Asn Glu Gln Glu Leu Leu Glu Leu Asp Lys Trp Ala Ser Leu 
        145                 150                 155          


Trp Asn Trp Phe 
    160      


<210>  14
<211>  34
<212>  PRT
<213>  Secuencia Artificial

<220>
<223>  CHR peptido W34L


<220>
<221>  peptido
<222>  (117)..(150)
<223>  CHR peptido W34L

<400>  14

Trp Met Glu Trp Asp Arg Glu Ile Asn Asn Tyr Thr Ser Leu Ile His 
117         120                 125                 130      


Ser Leu Ile Glu Glu Ser Gln Asn Gln Gln Glu Lys Asn Glu Gln Glu 
        135                 140                 145         


Leu Leu 
    150    


<210>  15
<211>  32
<212>  PRT
<213>  Secuencia Artificial

<220>
<223>  CHR peptido Q32Q


<220>
<221>  peptido
<222>  (110)..(141)
<223>  CHR peptido Q32Q

<400>  15

Gln Ile Trp Asn Asn Met Thr Trp Met Glu Trp Asp Arg Glu Ile Asn 
110                 115                 120                 125      


Asn Tyr Thr Ser Leu Ile His Ser Leu Ile Glu Glu Ser Gln Asn Gln 
                130                 135                 140          


<210>  16
<211>  20
<212>  PRT
<213>  Secuencia Artificial

<220>
<223>  CHR peptido Q20S


<220>
<221>  peptido
<222>  (110)..(129)
<223>  CHR peptido Q20S

<400>  16

Gln Ile Trp Asn Asn Met Thr Trp Met Glu Trp Asp Arg Glu Ile Asn 
110                 115                 120                 125      


Asn Tyr Thr Ser 
  


