                         SEQUENCE LISTING

<110>  VIROXIS
       CENTRE NATIONAL DE LA RECHERCHE SCIENTIFIQUE
       INSTITUT GUSTAVE ROUSSY
       UNIVERSITE PARIS SUD XI
 
<120>  MUTATED NON-PRIMATE LENTIVIRAL ENV PROTEINS ANT THEIR USE AS 
       DRUGS

<130>  WOB 13 BU VIR IGRA

<150>  EP 13 305 767
<151>  2013-06-07

<160>  502   

<170>  PatentIn version 3.5

<210>  1
<211>  9
<212>  PRT
<213>  Artificial sequence

<220>
<223>  Mutated sequence


<220>
<221>  MISC_FEATURE
<222>  (2)..(2)
<223>  Xaa is Ile or Met or Thr or Leu

<220>
<221>  MISC_FEATURE
<222>  (3)..(7)
<223>  Xaa is any natural occurring amino acid or is mutated

<400>  1

Ala Xaa Xaa Xaa Xaa Xaa Xaa Thr Ala 
1               5                   


<210>  2
<211>  17
<212>  PRT
<213>  FIV


<220>
<221>  MISC_FEATURE
<222>  (3)..(3)
<223>  Xaa is Lys or Thr or Arg

<220>
<221>  MISC_FEATURE
<222>  (4)..(4)
<223>  Xaa is Val or Ile

<220>
<221>  MISC_FEATURE
<222>  (5)..(5)
<223>  Xaa is Glu or Arg

<220>
<221>  MISC_FEATURE
<222>  (7)..(7)
<223>  Xaa is Ile or Met or Thr or Leu

<220>
<221>  MISC_FEATURE
<222>  (10)..(10)
<223>  Xaa is Phe or Pro

<220>
<221>  MISC_FEATURE
<222>  (11)..(11)
<223>  Xaa is Leu or Val or Ile

<220>
<221>  MISC_FEATURE
<222>  (15)..(15)
<223>  Xaa is Phe or Leu

<400>  2

Gly Leu Xaa Xaa Xaa Ala Xaa Glu Lys Xaa Xaa Tyr Thr Ala Xaa Ala 
1               5                   10                  15      


Met 
    


<210>  3
<211>  14
<212>  PRT
<213>  Artificial sequence

<220>
<223>  Mutated sequence


<220>
<221>  MISC_FEATURE
<222>  (1)..(1)
<223>  Xaa is Val or Ile

<220>
<221>  MISC_FEATURE
<222>  (2)..(2)
<223>  Xaa is Glu or Arg

<220>
<221>  MISC_FEATURE
<222>  (4)..(4)
<223>  Xaa is Ile or Met or Thr or leu

<220>
<221>  MISC_FEATURE
<222>  (5)..(9)
<223>  Xaa is any naturally occurring amino acid or is mutated

<220>
<221>  MISC_FEATURE
<222>  (12)..(12)
<223>  Xaa is Phe or leu

<400>  3

Xaa Xaa Ala Xaa Xaa Xaa Xaa Xaa Xaa Thr Ala Xaa Ala Met 
1               5                   10                  


<210>  4
<211>  856
<212>  PRT
<213>  FIV

<400>  4

Met Ala Glu Gly Phe Ala Ala Asn Arg Gln Trp Ile Gly Pro Glu Glu 
1               5                   10                  15      


Ala Glu Glu Leu Leu Asp Phe Asp Ile Ala Thr Gln Met Ser Glu Glu 
            20                  25                  30          


Gly Pro Leu Asn Pro Gly Val Asn Pro Phe Arg Val Pro Gly Ile Thr 
        35                  40                  45              


Glu Lys Glu Lys Gln Asn Tyr Cys Asn Ile Leu Gln Pro Lys Leu Gln 
    50                  55                  60                  


Asp Leu Arg Asn Glu Ile Gln Glu Val Lys Leu Glu Glu Gly Asn Ala 
65                  70                  75                  80  


Gly Lys Phe Arg Arg Ala Arg Phe Leu Arg Tyr Ser Asp Glu Arg Val 
                85                  90                  95      


Leu Ser Leu Val His Ala Phe Ile Gly Tyr Cys Ile Tyr Leu Gly Asn 
            100                 105                 110         


Arg Asn Lys Leu Gly Ser Leu Arg His Asp Ile Asp Ile Glu Ala Pro 
        115                 120                 125             


Gln Glu Glu Cys Tyr Asn Asn Arg Glu Lys Gly Thr Thr Asp Asn Ile 
    130                 135                 140                 


Lys Tyr Gly Arg Arg Cys Cys Leu Gly Thr Val Thr Leu Tyr Leu Ile 
145                 150                 155                 160 


Leu Phe Thr Gly Val Ile Val Tyr Ser Gln Thr Ala Gly Ala Gln Val 
                165                 170                 175     


Val Trp Arg Leu Pro Pro Leu Val Val Pro Val Glu Glu Ser Glu Ile 
            180                 185                 190         


Ile Phe Trp Asp Cys Trp Ala Pro Glu Glu Pro Ala Cys Gln Asp Phe 
        195                 200                 205             


Leu Gly Ala Met Ile His Leu Lys Ala Lys Thr Asn Ile Ser Ile Arg 
    210                 215                 220                 


Glu Gly Pro Thr Leu Gly Asn Trp Ala Arg Glu Ile Trp Ala Thr Leu 
225                 230                 235                 240 


Phe Lys Lys Ala Thr Arg Gln Cys Arg Arg Gly Arg Ile Trp Lys Arg 
                245                 250                 255     


Trp Asn Glu Thr Ile Thr Gly Pro Ser Gly Cys Ala Asn Asn Thr Cys 
            260                 265                 270         


Tyr Asn Val Ser Val Ile Val Pro Asp Tyr Gln Cys Tyr Leu Asp Arg 
        275                 280                 285             


Val Asp Thr Trp Leu Gln Gly Lys Ile Asn Ile Ser Leu Cys Leu Thr 
    290                 295                 300                 


Gly Gly Lys Met Leu Tyr Asn Lys Val Thr Lys Gln Leu Ser Tyr Cys 
305                 310                 315                 320 


Thr Asp Pro Leu Gln Ile Pro Leu Ile Asn Tyr Thr Phe Gly Pro Asn 
                325                 330                 335     


Gln Thr Cys Met Trp Asn Thr Ser Gln Ile Gln Asp Pro Glu Ile Pro 
            340                 345                 350         


Lys Cys Gly Trp Trp Asn Gln Met Ala Tyr Tyr Asn Ser Cys Lys Trp 
        355                 360                 365             


Glu Glu Ala Lys Val Lys Phe His Cys Gln Arg Thr Gln Ser Gln Pro 
    370                 375                 380                 


Gly Ser Trp Phe Arg Ala Ile Ser Ser Trp Lys Gln Arg Asn Arg Trp 
385                 390                 395                 400 


Glu Trp Arg Pro Asp Phe Lys Ser Lys Lys Val Lys Ile Ser Leu Pro 
                405                 410                 415     


Cys Asn Ser Thr Lys Asn Leu Thr Phe Ala Met Arg Ser Ser Gly Asp 
            420                 425                 430         


Tyr Gly Glu Val Thr Gly Ala Trp Ile Glu Phe Gly Cys His Arg Asn 
        435                 440                 445             


Lys Ser Asn Leu His Thr Glu Ala Arg Phe Arg Ile Arg Cys Arg Trp 
    450                 455                 460                 


Asn Val Gly Ser Asp Thr Ser Leu Ile Asp Thr Cys Gly Asn Thr Pro 
465                 470                 475                 480 


Asn Val Ser Gly Ala Asn Pro Val Asp Cys Thr Met Tyr Ser Asn Lys 
                485                 490                 495     


Met Tyr Asn Cys Ser Leu Gln Asn Gly Phe Thr Met Lys Val Asp Asp 
            500                 505                 510         


Leu Ile Val His Phe Asn Met Thr Lys Ala Val Glu Met Tyr Asn Ile 
        515                 520                 525             


Ala Gly Asn Trp Ser Cys Thr Ser Asp Leu Pro Ser Ser Trp Gly Tyr 
    530                 535                 540                 


Met Asn Cys Asn Cys Thr Asn Ser Ser Ser Ser Tyr Ser Gly Thr Lys 
545                 550                 555                 560 


Met Ala Cys Pro Ser Asn Arg Gly Ile Leu Arg Asn Trp Tyr Asn Pro 
                565                 570                 575     


Val Ala Gly Leu Arg Gln Ser Leu Glu Gln Tyr Gln Val Val Lys Gln 
            580                 585                 590         


Pro Asp Tyr Leu Leu Val Pro Glu Glu Val Met Glu Tyr Lys Pro Arg 
        595                 600                 605             


Arg Lys Arg Ala Ala Ile His Val Met Leu Ala Leu Ala Thr Val Leu 
    610                 615                 620                 


Ser Ile Ala Gly Ala Gly Thr Gly Ala Thr Ala Ile Gly Met Val Thr 
625                 630                 635                 640 


Gln Tyr His Gln Val Leu Ala Thr His Gln Glu Ala Ile Glu Lys Val 
                645                 650                 655     


Thr Gly Ala Leu Lys Ile Asn Asn Leu Arg Leu Val Thr Leu Glu His 
            660                 665                 670         


Gln Val Leu Val Ile Gly Leu Lys Val Glu Ala Met Glu Lys Phe Leu 
        675                 680                 685             


Tyr Thr Ala Phe Ala Met Gln Glu Leu Gly Cys Asn Gln Asn Gln Phe 
    690                 695                 700                 


Phe Cys Lys Ile Pro Leu Glu Leu Trp Thr Arg Tyr Asn Met Thr Ile 
705                 710                 715                 720 


Asn Gln Thr Ile Trp Asn His Gly Asn Ile Thr Leu Gly Glu Trp Tyr 
                725                 730                 735     


Asn Gln Thr Lys Asp Leu Gln Gln Lys Phe Tyr Glu Ile Ile Met Asp 
            740                 745                 750         


Ile Glu Gln Asn Asn Val Gln Gly Lys Thr Gly Ile Gln Gln Leu Gln 
        755                 760                 765             


Lys Trp Glu Asp Trp Val Arg Trp Ile Gly Asn Ile Pro Gln Tyr Leu 
    770                 775                 780                 


Lys Gly Leu Leu Gly Gly Ile Leu Gly Ile Gly Leu Gly Val Leu Leu 
785                 790                 795                 800 


Leu Ile Leu Cys Leu Pro Thr Leu Val Asp Cys Ile Arg Asn Cys Ile 
                805                 810                 815     


His Lys Ile Leu Gly Tyr Thr Val Ile Ala Met Pro Glu Val Glu Gly 
            820                 825                 830         


Glu Glu Ile Gln Pro Gln Met Glu Leu Arg Arg Asn Gly Arg Gln Cys 
        835                 840                 845             


Gly Met Ser Glu Lys Glu Glu Glu 
    850                 855     


<210>  5
<211>  856
<212>  PRT
<213>  Artificial sequence

<220>
<223>  Mutated sequence

<400>  5

Met Ala Glu Gly Phe Ala Ala Asn Arg Gln Trp Ile Gly Pro Glu Glu 
1               5                   10                  15      


Ala Glu Glu Leu Leu Asp Phe Asp Ile Ala Thr Gln Met Ser Glu Glu 
            20                  25                  30          


Gly Pro Leu Asn Pro Gly Val Asn Pro Phe Arg Val Pro Gly Ile Thr 
        35                  40                  45              


Glu Lys Glu Lys Gln Asn Tyr Cys Asn Ile Leu Gln Pro Lys Leu Gln 
    50                  55                  60                  


Asp Leu Arg Asn Glu Ile Gln Glu Val Lys Leu Glu Glu Gly Asn Ala 
65                  70                  75                  80  


Gly Lys Phe Arg Arg Ala Arg Phe Leu Arg Tyr Ser Asp Glu Arg Val 
                85                  90                  95      


Leu Ser Leu Val His Ala Phe Ile Gly Tyr Cys Ile Tyr Leu Gly Asn 
            100                 105                 110         


Arg Asn Lys Leu Gly Ser Leu Arg His Asp Ile Asp Ile Glu Ala Pro 
        115                 120                 125             


Gln Glu Glu Cys Tyr Asn Asn Arg Glu Lys Gly Thr Thr Asp Asn Ile 
    130                 135                 140                 


Lys Tyr Gly Arg Arg Cys Cys Leu Gly Thr Val Thr Leu Tyr Leu Ile 
145                 150                 155                 160 


Leu Phe Thr Gly Val Ile Val Tyr Ser Gln Thr Ala Gly Ala Gln Val 
                165                 170                 175     


Val Trp Arg Leu Pro Pro Leu Val Val Pro Val Glu Glu Ser Glu Ile 
            180                 185                 190         


Ile Phe Trp Asp Cys Trp Ala Pro Glu Glu Pro Ala Cys Gln Asp Phe 
        195                 200                 205             


Leu Gly Ala Met Ile His Leu Lys Ala Lys Thr Asn Ile Ser Ile Arg 
    210                 215                 220                 


Glu Gly Pro Thr Leu Gly Asn Trp Ala Arg Glu Ile Trp Ala Thr Leu 
225                 230                 235                 240 


Phe Lys Lys Ala Thr Arg Gln Cys Arg Arg Gly Arg Ile Trp Lys Arg 
                245                 250                 255     


Trp Asn Glu Thr Ile Thr Gly Pro Ser Gly Cys Ala Asn Asn Thr Cys 
            260                 265                 270         


Tyr Asn Val Ser Val Ile Val Pro Asp Tyr Gln Cys Tyr Leu Asp Arg 
        275                 280                 285             


Val Asp Thr Trp Leu Gln Gly Lys Ile Asn Ile Ser Leu Cys Leu Thr 
    290                 295                 300                 


Gly Gly Lys Met Leu Tyr Asn Lys Val Thr Lys Gln Leu Ser Tyr Cys 
305                 310                 315                 320 


Thr Asp Pro Leu Gln Ile Pro Leu Ile Asn Tyr Thr Phe Gly Pro Asn 
                325                 330                 335     


Gln Thr Cys Met Trp Asn Thr Ser Gln Ile Gln Asp Pro Glu Ile Pro 
            340                 345                 350         


Lys Cys Gly Trp Trp Asn Gln Met Ala Tyr Tyr Asn Ser Cys Lys Trp 
        355                 360                 365             


Glu Glu Ala Lys Val Lys Phe His Cys Gln Arg Thr Gln Ser Gln Pro 
    370                 375                 380                 


Gly Ser Trp Phe Arg Ala Ile Ser Ser Trp Lys Gln Arg Asn Arg Trp 
385                 390                 395                 400 


Glu Trp Arg Pro Asp Phe Lys Ser Lys Lys Val Lys Ile Ser Leu Pro 
                405                 410                 415     


Cys Asn Ser Thr Lys Asn Leu Thr Phe Ala Met Arg Ser Ser Gly Asp 
            420                 425                 430         


Tyr Gly Glu Val Thr Gly Ala Trp Ile Glu Phe Gly Cys His Arg Asn 
        435                 440                 445             


Lys Ser Asn Leu His Thr Glu Ala Arg Phe Arg Ile Arg Cys Arg Trp 
    450                 455                 460                 


Asn Val Gly Ser Asp Thr Ser Leu Ile Asp Thr Cys Gly Asn Thr Pro 
465                 470                 475                 480 


Asn Val Ser Gly Ala Asn Pro Val Asp Cys Thr Met Tyr Ser Asn Lys 
                485                 490                 495     


Met Tyr Asn Cys Ser Leu Gln Asn Gly Phe Thr Met Lys Val Asp Asp 
            500                 505                 510         


Leu Ile Val His Phe Asn Met Thr Lys Ala Val Glu Met Tyr Asn Ile 
        515                 520                 525             


Ala Gly Asn Trp Ser Cys Thr Ser Asp Leu Pro Ser Ser Trp Gly Tyr 
    530                 535                 540                 


Met Asn Cys Asn Cys Thr Asn Ser Ser Ser Ser Tyr Ser Gly Thr Lys 
545                 550                 555                 560 


Met Ala Cys Pro Ser Asn Arg Gly Ile Leu Arg Asn Trp Tyr Asn Pro 
                565                 570                 575     


Val Ala Gly Leu Arg Gln Ser Leu Glu Gln Tyr Gln Val Val Lys Gln 
            580                 585                 590         


Pro Asp Tyr Leu Leu Val Pro Glu Glu Val Met Glu Tyr Lys Pro Arg 
        595                 600                 605             


Arg Lys Arg Ala Ala Ile His Val Met Leu Ala Leu Ala Thr Val Leu 
    610                 615                 620                 


Ser Ile Ala Gly Ala Gly Thr Gly Ala Thr Ala Ile Gly Met Val Thr 
625                 630                 635                 640 


Gln Tyr His Gln Val Leu Ala Thr His Gln Glu Ala Ile Glu Lys Val 
                645                 650                 655     


Thr Gly Ala Leu Lys Ile Asn Asn Leu Arg Leu Val Thr Leu Glu His 
            660                 665                 670         


Gln Val Leu Val Ile Gly Leu Lys Val Glu Ala Met Glu Lys Arg Leu 
        675                 680                 685             


Tyr Thr Ala Phe Ala Met Gln Glu Leu Gly Cys Asn Gln Asn Gln Phe 
    690                 695                 700                 


Phe Cys Lys Ile Pro Leu Glu Leu Trp Thr Arg Tyr Asn Met Thr Ile 
705                 710                 715                 720 


Asn Gln Thr Ile Trp Asn His Gly Asn Ile Thr Leu Gly Glu Trp Tyr 
                725                 730                 735     


Asn Gln Thr Lys Asp Leu Gln Gln Lys Phe Tyr Glu Ile Ile Met Asp 
            740                 745                 750         


Ile Glu Gln Asn Asn Val Gln Gly Lys Thr Gly Ile Gln Gln Leu Gln 
        755                 760                 765             


Lys Trp Glu Asp Trp Val Arg Trp Ile Gly Asn Ile Pro Gln Tyr Leu 
    770                 775                 780                 


Lys Gly Leu Leu Gly Gly Ile Leu Gly Ile Gly Leu Gly Val Leu Leu 
785                 790                 795                 800 


Leu Ile Leu Cys Leu Pro Thr Leu Val Asp Cys Ile Arg Asn Cys Ile 
                805                 810                 815     


His Lys Ile Leu Gly Tyr Thr Val Ile Ala Met Pro Glu Val Glu Gly 
            820                 825                 830         


Glu Glu Ile Gln Pro Gln Met Glu Leu Arg Arg Asn Gly Arg Gln Cys 
        835                 840                 845             


Gly Met Ser Glu Lys Glu Glu Glu 
    850                 855     


<210>  6
<211>  64
<212>  PRT
<213>  FIV

<400>  6

Ala Ile Glu Lys Val Thr Gly Ala Leu Lys Ile Asn Asn Leu Arg Leu 
1               5                   10                  15      


Val Thr Leu Glu His Gln Val Leu Val Ile Gly Leu Lys Val Glu Ala 
            20                  25                  30          


Met Glu Lys Phe Leu Tyr Thr Ala Phe Ala Met Gln Glu Leu Gly Cys 
        35                  40                  45              


Asn Gln Asn Gln Phe Phe Cys Lys Ile Pro Leu Glu Leu Trp Thr Arg 
    50                  55                  60                  


<210>  7
<211>  64
<212>  PRT
<213>  FIV

<400>  7

Ala Val Glu Lys Val Thr Glu Ala Leu Lys Ile Asn Asn Leu Arg Leu 
1               5                   10                  15      


Val Thr Leu Glu His Gln Val Leu Val Ile Gly Leu Lys Val Glu Ala 
            20                  25                  30          


Met Glu Lys Phe Leu Tyr Thr Ala Phe Ala Met Gln Glu Leu Gly Cys 
        35                  40                  45              


Asn Gln Asn Gln Phe Phe Cys Lys Ile Pro Pro Glu Leu Trp Thr Arg 
    50                  55                  60                  


<210>  8
<211>  64
<212>  PRT
<213>  FIV

<400>  8

Ala Ile Glu Lys Val Thr Glu Ala Leu Lys Ile Thr Asn Leu Arg Leu 
1               5                   10                  15      


Val Thr Leu Glu His Gln Val Leu Val Ile Gly Leu Lys Val Glu Ala 
            20                  25                  30          


Met Glu Lys Phe Leu Tyr Thr Ala Phe Ala Met Gln Glu Leu Gly Cys 
        35                  40                  45              


Asn Gln Asn Gln Phe Phe Cys Lys Val Pro Pro Glu Leu Trp Arg Arg 
    50                  55                  60                  


<210>  9
<211>  64
<212>  PRT
<213>  FIV

<400>  9

Ala Ile Glu Lys Val Thr Glu Ala Leu Lys Ile Asn Asn Leu Arg Leu 
1               5                   10                  15      


Val Thr Leu Glu His Gln Val Leu Val Ile Gly Leu Lys Val Glu Ala 
            20                  25                  30          


Ile Glu Lys Phe Leu Tyr Thr Ala Phe Ala Met Gln Glu Leu Gly Cys 
        35                  40                  45              


Asn Gln Asn Gln Phe Phe Cys Lys Val Pro Leu Glu Leu Trp Arg Arg 
    50                  55                  60                  


<210>  10
<211>  64
<212>  PRT
<213>  FIV

<400>  10

Ala Ile Glu Lys Val Thr Glu Ala Leu Lys Ile Asn Asn Leu Arg Leu 
1               5                   10                  15      


Val Thr Leu Glu His Gln Val Leu Val Ile Gly Leu Lys Val Glu Ala 
            20                  25                  30          


Met Glu Lys Phe Leu Tyr Thr Ala Phe Ala Met Gln Glu Leu Gly Cys 
        35                  40                  45              


Asn Gln Asn Gln Phe Phe Cys Lys Val Pro Ser Ala Leu Trp Glu Arg 
    50                  55                  60                  


<210>  11
<211>  64
<212>  PRT
<213>  FIV

<400>  11

Ala Ile Glu Lys Val Thr Glu Ala Leu Lys Ile Asn Asn Leu Arg Leu 
1               5                   10                  15      


Val Thr Leu Glu His Gln Val Leu Val Ile Gly Leu Lys Val Glu Ala 
            20                  25                  30          


Met Glu Lys Phe Leu Tyr Thr Ala Phe Ala Met Gln Glu Leu Gly Cys 
        35                  40                  45              


Asn Gln Asn Gln Phe Phe Cys Lys Ile Pro Pro Gly Leu Trp Thr Arg 
    50                  55                  60                  


<210>  12
<211>  64
<212>  PRT
<213>  FIV

<400>  12

Ala Ile Glu Lys Val Thr Glu Ala Leu Lys Ile Asn Asn Leu Arg Leu 
1               5                   10                  15      


Val Thr Leu Glu His Gln Val Leu Val Ile Gly Leu Lys Val Glu Ala 
            20                  25                  30          


Met Glu Lys Phe Leu Tyr Thr Ala Phe Ala Met Gln Glu Leu Gly Cys 
        35                  40                  45              


Asn Gln Asn Gln Phe Phe Cys Lys Val Pro Pro Gln Leu Trp Lys Arg 
    50                  55                  60                  


<210>  13
<211>  64
<212>  PRT
<213>  FIV

<400>  13

Ala Ile Glu Lys Val Thr Glu Ala Leu Lys Val Asn Asn Leu Arg Leu 
1               5                   10                  15      


Ile Thr Leu Glu His Gln Val Leu Val Ile Gly Leu Lys Val Glu Ala 
            20                  25                  30          


Met Glu Lys Phe Leu Tyr Thr Ala Phe Ala Met Gln Glu Leu Gly Cys 
        35                  40                  45              


Asn Gln Asn Gln Phe Phe Cys Lys Val Pro Pro Glu Leu Trp Lys Arg 
    50                  55                  60                  


<210>  14
<211>  64
<212>  PRT
<213>  FIV

<400>  14

Thr Ile Glu Lys Val Thr Glu Ala Leu Lys Ile Asn Asn Leu Arg Leu 
1               5                   10                  15      


Val Thr Leu Glu His Gln Val Leu Val Ile Gly Leu Lys Val Glu Ala 
            20                  25                  30          


Met Glu Lys Phe Leu Tyr Thr Ala Phe Ala Met Gln Glu Leu Gly Cys 
        35                  40                  45              


Asn Gln Asn Gln Phe Phe Cys Lys Val Pro Pro Glu Leu Trp Lys Arg 
    50                  55                  60                  


<210>  15
<211>  64
<212>  PRT
<213>  FIV

<400>  15

Ala Ile Glu Lys Val Thr Glu Ala Leu Lys Ile Asn Asn Leu Arg Leu 
1               5                   10                  15      


Val Thr Leu Glu His Gln Val Leu Val Ile Gly Leu Lys Val Glu Ala 
            20                  25                  30          


Met Glu Lys Phe Leu Tyr Thr Ala Phe Ala Met Gln Glu Leu Gly Cys 
        35                  40                  45              


Asn Gln Asn Gln Phe Phe Cys Lys Val Pro Pro Val Leu Trp Glu Arg 
    50                  55                  60                  


<210>  16
<211>  64
<212>  PRT
<213>  FIV

<400>  16

Thr Ile Glu Lys Ile Thr Glu Ala Leu Lys Val Asn Asn Leu Arg Leu 
1               5                   10                  15      


Val Thr Leu Glu His Gln Val Leu Val Ile Gly Leu Lys Val Glu Ala 
            20                  25                  30          


Ile Glu Lys Phe Leu Tyr Thr Ala Phe Ala Met Gln Glu Leu Gly Cys 
        35                  40                  45              


Asn Gln Asn Gln Phe Phe Cys Lys Val Pro Pro Glu Leu Trp Gln Arg 
    50                  55                  60                  


<210>  17
<211>  64
<212>  PRT
<213>  FIV

<400>  17

Ala Ile Asp Gln Ile Thr Glu Ala Leu Lys Ile Asn Asn Leu Arg Leu 
1               5                   10                  15      


Val Thr Leu Glu His Gln Val Leu Val Ile Gly Leu Lys Val Glu Ala 
            20                  25                  30          


Ile Glu Lys Phe Ile Tyr Thr Ala Phe Ala Met Gln Glu Leu Gly Cys 
        35                  40                  45              


Asn Gln Asn Gln Phe Phe Cys Lys Ile Pro Pro Glu Leu Trp Ile Arg 
    50                  55                  60                  


<210>  18
<211>  64
<212>  PRT
<213>  FIV

<400>  18

Ala Leu Asp Lys Ile Thr Glu Ala Leu Lys Ile Asn Asn Leu Arg Leu 
1               5                   10                  15      


Ile Thr Leu Glu His Gln Val Leu Val Ile Gly Leu Lys Val Glu Ala 
            20                  25                  30          


Ile Glu Lys Phe Leu Tyr Thr Ala Phe Ala Met Gln Glu Leu Gly Cys 
        35                  40                  45              


Asn Gln Asn Gln Phe Phe Cys Lys Ile Pro Pro Ser Leu Trp Ser Met 
    50                  55                  60                  


<210>  19
<211>  64
<212>  PRT
<213>  FIV

<400>  19

Ala Leu Asp Lys Ile Thr Glu Ala Leu Lys Ile Asn Asn Leu Arg Leu 
1               5                   10                  15      


Val Thr Leu Glu His Gln Val Leu Val Ile Gly Leu Lys Val Glu Ala 
            20                  25                  30          


Thr Glu Lys Phe Leu Tyr Thr Ala Phe Ala Met Gln Glu Leu Gly Cys 
        35                  40                  45              


Asn Gln Asn Gln Phe Phe Cys Lys Ile Pro Cys Glu Leu Trp Met Arg 
    50                  55                  60                  


<210>  20
<211>  64
<212>  PRT
<213>  FIV

<400>  20

Ala Leu Glu Lys Ile Thr Glu Ala Leu Lys Ile Asn Asn Leu Arg Leu 
1               5                   10                  15      


Val Thr Leu Glu His Gln Val Leu Met Ile Gly Leu Lys Val Glu Ala 
            20                  25                  30          


Ile Glu Lys Phe Leu Tyr Thr Ala Phe Ala Met Gln Glu Leu Gly Cys 
        35                  40                  45              


Asn Gln Asn Gln Phe Phe Cys Lys Ile Pro Leu Asn Leu Trp Thr Met 
    50                  55                  60                  


<210>  21
<211>  64
<212>  PRT
<213>  FIV

<400>  21

Ala Leu Asp Lys Ile Thr Glu Ala Leu Lys Ile Asn Asn Leu Arg Leu 
1               5                   10                  15      


Ile Thr Leu Val His Gln Val Leu Val Ile Gly Leu Lys Val Arg Ala 
            20                  25                  30          


Ile Glu Lys Pro Leu Tyr Thr Ala Phe Ala Met Gln Glu Leu Gly Cys 
        35                  40                  45              


Asn Gln Asn Gln Phe Phe Cys Lys Ile Pro Pro Ser Leu Trp Ser Met 
    50                  55                  60                  


<210>  22
<211>  64
<212>  PRT
<213>  FIV

<400>  22

Ala Leu Glu Lys Ile Thr Glu Ala Leu Lys Ile Asn Asn Leu Arg Leu 
1               5                   10                  15      


Ile Thr Leu Glu His Gln Val Leu Val Ile Gly Leu Arg Val Glu Ala 
            20                  25                  30          


Ile Glu Lys Phe Leu Tyr Thr Ala Phe Ala Met Gln Glu Leu Gly Cys 
        35                  40                  45              


Asn Gln Asn Gln Phe Phe Cys Lys Ile Pro Pro Ser Leu Trp Ser Met 
    50                  55                  60                  


<210>  23
<211>  64
<212>  PRT
<213>  FIV

<400>  23

Ala Leu Glu Lys Ile Thr Glu Ala Leu Lys Ile Asn Asn Leu Arg Leu 
1               5                   10                  15      


Ile Thr Leu Glu His Gln Val Leu Val Ile Gly Leu Lys Val Glu Ala 
            20                  25                  30          


Ile Glu Lys Phe Leu Tyr Thr Ala Phe Ala Met Gln Glu Leu Gly Cys 
        35                  40                  45              


His Gln Asn Gln Phe Phe Cys Lys Ile Pro Pro Ser Leu Trp Ser Met 
    50                  55                  60                  


<210>  24
<211>  64
<212>  PRT
<213>  FIV

<400>  24

Ala Leu Asp Lys Ile Thr Glu Ala Leu Lys Ile Asn Asn Leu Arg Leu 
1               5                   10                  15      


Ile Thr Leu Glu His Gln Val Leu Val Ile Gly Leu Lys Val Glu Ala 
            20                  25                  30          


Ile Glu Lys Phe Leu Tyr Thr Ala Phe Ala Met Gln Glu Leu Gly Cys 
        35                  40                  45              


Asn Gln Asn Gln Phe Phe Cys Lys Ile Pro Pro Ser Leu Trp Ser Met 
    50                  55                  60                  


<210>  25
<211>  64
<212>  PRT
<213>  FIV

<400>  25

Ala Leu Asp Lys Ile Thr Gln Ala Leu Lys Ile Asn Asn Leu Arg Leu 
1               5                   10                  15      


Ile Thr Leu Glu His Gln Val Leu Val Ile Gly Leu Lys Val Glu Ala 
            20                  25                  30          


Ile Glu Lys Phe Leu Tyr Thr Ala Phe Ala Met Gln Glu Leu Gly Cys 
        35                  40                  45              


Asn Gln Asn Gln Phe Phe Cys Lys Ile Pro Pro Ser Leu Trp Ser Met 
    50                  55                  60                  


<210>  26
<211>  64
<212>  PRT
<213>  FIV

<400>  26

Ala Leu Asp Lys Ile Thr Glu Ala Leu Lys Ile Asn Asn Leu Arg Leu 
1               5                   10                  15      


Ile Thr Leu Glu His Gln Val Leu Val Ile Gly Leu Lys Val Glu Ala 
            20                  25                  30          


Ile Glu Lys Phe Leu Tyr Thr Ala Phe Ala Met Gln Glu Leu Gly Cys 
        35                  40                  45              


Asn Gln Asn Gln Phe Phe Cys Lys Ile Pro Leu Asn Leu Trp Asn Met 
    50                  55                  60                  


<210>  27
<211>  64
<212>  PRT
<213>  FIV

<400>  27

Ala Leu Asp Lys Ile Thr Glu Ala Leu Lys Ile Asn Asn Leu Arg Leu 
1               5                   10                  15      


Val Thr Leu Glu His Gln Met Leu Val Ile Gly Leu Lys Val Glu Ala 
            20                  25                  30          


Ile Glu Lys Phe Leu Tyr Thr Ala Phe Ala Met Gln Glu Leu Gly Cys 
        35                  40                  45              


Asn Gln Asn Gln Phe Phe Cys Glu Ile Pro Lys Glu Leu Trp Leu Arg 
    50                  55                  60                  


<210>  28
<211>  9
<212>  PRT
<213>  Artificial sequence

<220>
<223>  Mutated sequence

<400>  28

Ala Ile Glu Lys Arg Leu Tyr Thr Ala 
1               5                   


<210>  29
<211>  9
<212>  PRT
<213>  Artificial sequence

<220>
<223>  Mutated sequence

<400>  29

Ala Met Glu Lys Arg Leu Tyr Thr Ala 
1               5                   


<210>  30
<211>  9
<212>  PRT
<213>  Artificial sequence

<220>
<223>  Mutated sequence

<400>  30

Ala Thr Glu Lys Arg Leu Tyr Thr Ala 
1               5                   


<210>  31
<211>  9
<212>  PRT
<213>  Artificial sequence

<220>
<223>  Mutated sequence

<400>  31

Ala Leu Glu Lys Arg Leu Tyr Thr Ala 
1               5                   


<210>  32
<211>  9
<212>  PRT
<213>  Artificial sequence

<220>
<223>  Mutated sequence

<400>  32

Ala Ile Glu Lys Arg Val Tyr Thr Ala 
1               5                   


<210>  33
<211>  9
<212>  PRT
<213>  Artificial sequence

<220>
<223>  Mutated sequence

<400>  33

Ala Met Glu Lys Arg Val Tyr Thr Ala 
1               5                   


<210>  34
<211>  9
<212>  PRT
<213>  Artificial sequence

<220>
<223>  Mutated sequence

<400>  34

Ala Thr Glu Lys Arg Val Tyr Thr Ala 
1               5                   


<210>  35
<211>  9
<212>  PRT
<213>  Artificial sequence

<220>
<223>  Mutated sequence

<400>  35

Ala Leu Glu Lys Arg Val Tyr Thr Ala 
1               5                   


<210>  36
<211>  9
<212>  PRT
<213>  Artificial sequence

<220>
<223>  Mutated sequence

<400>  36

Ala Ile Glu Lys Arg Ile Tyr Thr Ala 
1               5                   


<210>  37
<211>  9
<212>  PRT
<213>  Artificial sequence

<220>
<223>  Mutated sequence

<400>  37

Ala Met Glu Lys Arg Ile Tyr Thr Ala 
1               5                   


<210>  38
<211>  9
<212>  PRT
<213>  Artificial sequence

<220>
<223>  Mutated sequence

<400>  38

Ala Thr Glu Lys Arg Ile Tyr Thr Ala 
1               5                   


<210>  39
<211>  9
<212>  PRT
<213>  Artificial sequence

<220>
<223>  Mutated sequence

<400>  39

Ala Leu Glu Lys Arg Ile Tyr Thr Ala 
1               5                   


<210>  40
<211>  9
<212>  PRT
<213>  Artificial sequence

<220>
<223>  Mutated sequence

<400>  40

Ala Ile Glu Lys Gly Leu Tyr Thr Ala 
1               5                   


<210>  41
<211>  9
<212>  PRT
<213>  Artificial sequence

<220>
<223>  Mutated sequence

<400>  41

Ala Met Glu Lys Gly Leu Tyr Thr Ala 
1               5                   


<210>  42
<211>  9
<212>  PRT
<213>  Artificial sequence

<220>
<223>  Mutated sequence

<400>  42

Ala Thr Glu Lys Gly Leu Tyr Thr Ala 
1               5                   


<210>  43
<211>  9
<212>  PRT
<213>  Artificial sequence

<220>
<223>  Mutated sequence

<400>  43

Ala Leu Glu Lys Gly Leu Tyr Thr Ala 
1               5                   


<210>  44
<211>  9
<212>  PRT
<213>  Artificial sequence

<220>
<223>  Mutated sequence

<400>  44

Ala Ile Glu Lys Gly Val Tyr Thr Ala 
1               5                   


<210>  45
<211>  9
<212>  PRT
<213>  Artificial sequence

<220>
<223>  Mutated sequence

<400>  45

Ala Met Glu Lys Gly Val Tyr Thr Ala 
1               5                   


<210>  46
<211>  9
<212>  PRT
<213>  Artificial sequence

<220>
<223>  Mutated sequence

<400>  46

Ala Thr Glu Lys Gly Val Tyr Thr Ala 
1               5                   


<210>  47
<211>  9
<212>  PRT
<213>  Artificial sequence

<220>
<223>  Mutated sequence

<400>  47

Ala Leu Glu Lys Gly Val Tyr Thr Ala 
1               5                   


<210>  48
<211>  9
<212>  PRT
<213>  Artificial sequence

<220>
<223>  Mutated sequence

<400>  48

Ala Ile Glu Lys Gly Ile Tyr Thr Ala 
1               5                   


<210>  49
<211>  9
<212>  PRT
<213>  Artificial sequence

<220>
<223>  Mutated sequence

<400>  49

Ala Met Glu Lys Gly Ile Tyr Thr Ala 
1               5                   


<210>  50
<211>  9
<212>  PRT
<213>  Artificial sequence

<220>
<223>  Mutated sequence

<400>  50

Ala Thr Glu Lys Gly Ile Tyr Thr Ala 
1               5                   


<210>  51
<211>  9
<212>  PRT
<213>  Artificial sequence

<220>
<223>  Mutated sequence

<400>  51

Ala Leu Glu Lys Gly Ile Tyr Thr Ala 
1               5                   


<210>  52
<211>  9
<212>  PRT
<213>  Artificial sequence

<220>
<223>  Mutated sequence

<400>  52

Ala Ile Glu Lys Leu Leu Tyr Thr Ala 
1               5                   


<210>  53
<211>  9
<212>  PRT
<213>  Artificial sequence

<220>
<223>  Mutated sequence

<400>  53

Ala Met Glu Lys Leu Leu Tyr Thr Ala 
1               5                   


<210>  54
<211>  9
<212>  PRT
<213>  Artificial sequence

<220>
<223>  Mutated sequence

<400>  54

Ala Thr Glu Lys Leu Leu Tyr Thr Ala 
1               5                   


<210>  55
<211>  9
<212>  PRT
<213>  Artificial sequence

<220>
<223>  Mutated sequence

<400>  55

Ala Leu Glu Lys Leu Leu Tyr Thr Ala 
1               5                   


<210>  56
<211>  9
<212>  PRT
<213>  Artificial sequence

<220>
<223>  Mutated sequence

<400>  56

Ala Ile Glu Lys Leu Val Tyr Thr Ala 
1               5                   


<210>  57
<211>  9
<212>  PRT
<213>  Artificial sequence

<220>
<223>  Mutated sequence

<400>  57

Ala Met Glu Lys Leu Val Tyr Thr Ala 
1               5                   


<210>  58
<211>  9
<212>  PRT
<213>  Artificial sequence

<220>
<223>  Mutated sequence

<400>  58

Ala Thr Glu Lys Leu Val Tyr Thr Ala 
1               5                   


<210>  59
<211>  9
<212>  PRT
<213>  Artificial sequence

<220>
<223>  Mutated sequence

<400>  59

Ala Leu Glu Lys Leu Val Tyr Thr Ala 
1               5                   


<210>  60
<211>  9
<212>  PRT
<213>  Artificial sequence

<220>
<223>  Mutated sequence

<400>  60

Ala Ile Glu Lys Leu Ile Tyr Thr Ala 
1               5                   


<210>  61
<211>  9
<212>  PRT
<213>  Artificial sequence

<220>
<223>  Mutated sequence

<400>  61

Ala Met Glu Lys Leu Ile Tyr Thr Ala 
1               5                   


<210>  62
<211>  9
<212>  PRT
<213>  Artificial sequence

<220>
<223>  Mutated sequence

<400>  62

Ala Thr Glu Lys Leu Ile Tyr Thr Ala 
1               5                   


<210>  63
<211>  9
<212>  PRT
<213>  Artificial sequence

<220>
<223>  Mutated sequence

<400>  63

Ala Leu Glu Lys Leu Ile Tyr Thr Ala 
1               5                   


<210>  64
<211>  9
<212>  PRT
<213>  Artificial sequence

<220>
<223>  Mutated sequence

<400>  64

Ala Ile Glu Lys Ala Leu Tyr Thr Ala 
1               5                   


<210>  65
<211>  9
<212>  PRT
<213>  Artificial sequence

<220>
<223>  Mutated sequence

<400>  65

Ala Met Glu Lys Ala Leu Tyr Thr Ala 
1               5                   


<210>  66
<211>  9
<212>  PRT
<213>  Artificial sequence

<220>
<223>  Mutated sequence

<400>  66

Ala Thr Glu Lys Ala Leu Tyr Thr Ala 
1               5                   


<210>  67
<211>  9
<212>  PRT
<213>  Artificial sequence

<220>
<223>  Mutated sequence

<400>  67

Ala Leu Glu Lys Ala Leu Tyr Thr Ala 
1               5                   


<210>  68
<211>  9
<212>  PRT
<213>  Artificial sequence

<220>
<223>  Mutated sequence

<400>  68

Ala Ile Glu Lys Ala Val Tyr Thr Ala 
1               5                   


<210>  69
<211>  9
<212>  PRT
<213>  Artificial sequence

<220>
<223>  Mutated sequence

<400>  69

Ala Met Glu Lys Ala Val Tyr Thr Ala 
1               5                   


<210>  70
<211>  9
<212>  PRT
<213>  Artificial sequence

<220>
<223>  Mutated sequence

<400>  70

Ala Thr Glu Lys Ala Val Tyr Thr Ala 
1               5                   


<210>  71
<211>  9
<212>  PRT
<213>  Artificial sequence

<220>
<223>  Mutated sequence

<400>  71

Ala Leu Glu Lys Ala Val Tyr Thr Ala 
1               5                   


<210>  72
<211>  9
<212>  PRT
<213>  Artificial sequence

<220>
<223>  Mutated sequence

<400>  72

Ala Ile Glu Lys Ala Ile Tyr Thr Ala 
1               5                   


<210>  73
<211>  9
<212>  PRT
<213>  Artificial sequence

<220>
<223>  Mutated sequence

<400>  73

Ala Met Glu Lys Ala Ile Tyr Thr Ala 
1               5                   


<210>  74
<211>  9
<212>  PRT
<213>  Artificial sequence

<220>
<223>  Mutated sequence

<400>  74

Ala Thr Glu Lys Ala Ile Tyr Thr Ala 
1               5                   


<210>  75
<211>  9
<212>  PRT
<213>  Artificial sequence

<220>
<223>  Mutated sequence

<400>  75

Ala Leu Glu Lys Ala Ile Tyr Thr Ala 
1               5                   


<210>  76
<211>  9
<212>  PRT
<213>  Artificial sequence

<220>
<223>  Mutated sequence

<400>  76

Ala Ile Glu Lys Phe Arg Tyr Thr Ala 
1               5                   


<210>  77
<211>  9
<212>  PRT
<213>  Artificial sequence

<220>
<223>  Mutated sequence

<400>  77

Ala Met Glu Lys Phe Arg Tyr Thr Ala 
1               5                   


<210>  78
<211>  9
<212>  PRT
<213>  Artificial sequence

<220>
<223>  Mutated sequence

<400>  78

Ala Thr Glu Lys Phe Arg Tyr Thr Ala 
1               5                   


<210>  79
<211>  9
<212>  PRT
<213>  Artificial sequence

<220>
<223>  Mutated sequence

<400>  79

Ala Leu Glu Lys Phe Arg Tyr Thr Ala 
1               5                   


<210>  80
<211>  9
<212>  PRT
<213>  Artificial sequence

<220>
<223>  Mutated sequence

<400>  80

Ala Ile Glu Lys Pro Arg Tyr Thr Ala 
1               5                   


<210>  81
<211>  9
<212>  PRT
<213>  Artificial sequence

<220>
<223>  Mutated sequence

<400>  81

Ala Met Glu Lys Pro Arg Tyr Thr Ala 
1               5                   


<210>  82
<211>  9
<212>  PRT
<213>  Artificial sequence

<220>
<223>  Mutated sequence

<400>  82

Ala Thr Glu Lys Pro Arg Tyr Thr Ala 
1               5                   


<210>  83
<211>  9
<212>  PRT
<213>  Artificial sequence

<220>
<223>  Mutated sequence

<400>  83

Ala Leu Glu Lys Pro Arg Tyr Thr Ala 
1               5                   


<210>  84
<211>  9
<212>  PRT
<213>  Artificial sequence

<220>
<223>  Mutated sequence

<400>  84

Ala Ile Glu Lys Phe Gly Tyr Thr Ala 
1               5                   


<210>  85
<211>  9
<212>  PRT
<213>  Artificial sequence

<220>
<223>  Mutated sequence

<400>  85

Ala Met Glu Lys Phe Gly Tyr Thr Ala 
1               5                   


<210>  86
<211>  9
<212>  PRT
<213>  Artificial sequence

<220>
<223>  Mutated sequence

<400>  86

Ala Thr Glu Lys Phe Gly Tyr Thr Ala 
1               5                   


<210>  87
<211>  9
<212>  PRT
<213>  Artificial sequence

<220>
<223>  Mutated sequence

<400>  87

Ala Leu Glu Lys Phe Gly Tyr Thr Ala 
1               5                   


<210>  88
<211>  9
<212>  PRT
<213>  Artificial sequence

<220>
<223>  Mutated sequence

<400>  88

Ala Ile Glu Lys Pro Gly Tyr Thr Ala 
1               5                   


<210>  89
<211>  9
<212>  PRT
<213>  Artificial sequence

<220>
<223>  Mutated sequence

<400>  89

Ala Met Glu Lys Pro Gly Tyr Thr Ala 
1               5                   


<210>  90
<211>  9
<212>  PRT
<213>  Artificial sequence

<220>
<223>  Mutated sequence

<400>  90

Ala Thr Glu Lys Pro Gly Tyr Thr Ala 
1               5                   


<210>  91
<211>  9
<212>  PRT
<213>  Artificial sequence

<220>
<223>  Mutated sequence

<400>  91

Ala Leu Glu Lys Pro Gly Tyr Thr Ala 
1               5                   


<210>  92
<211>  9
<212>  PRT
<213>  Artificial sequence

<220>
<223>  Mutated sequence

<400>  92

Ala Ile Glu Lys Phe Phe Tyr Thr Ala 
1               5                   


<210>  93
<211>  9
<212>  PRT
<213>  Artificial sequence

<220>
<223>  Mutated sequence

<400>  93

Ala Met Glu Lys Phe Phe Tyr Thr Ala 
1               5                   


<210>  94
<211>  9
<212>  PRT
<213>  Artificial sequence

<220>
<223>  Mutated sequence

<400>  94

Ala Thr Glu Lys Phe Phe Tyr Thr Ala 
1               5                   


<210>  95
<211>  9
<212>  PRT
<213>  Artificial sequence

<220>
<223>  Mutated sequence

<400>  95

Ala Leu Glu Lys Phe Phe Tyr Thr Ala 
1               5                   


<210>  96
<211>  9
<212>  PRT
<213>  Artificial sequence

<220>
<223>  Mutated sequence

<400>  96

Ala Ile Glu Lys Pro Phe Tyr Thr Ala 
1               5                   


<210>  97
<211>  9
<212>  PRT
<213>  Artificial sequence

<220>
<223>  Mutated sequence

<400>  97

Ala Met Glu Lys Pro Phe Tyr Thr Ala 
1               5                   


<210>  98
<211>  9
<212>  PRT
<213>  Artificial sequence

<220>
<223>  Mutated sequence

<400>  98

Ala Thr Glu Lys Pro Phe Tyr Thr Ala 
1               5                   


<210>  99
<211>  9
<212>  PRT
<213>  Artificial sequence

<220>
<223>  Mutated sequence

<400>  99

Ala Leu Glu Lys Pro Phe Tyr Thr Ala 
1               5                   


<210>  100
<211>  9
<212>  PRT
<213>  Artificial sequence

<220>
<223>  Mutated sequence

<400>  100

Ala Ile Glu Lys Phe Ala Tyr Thr Ala 
1               5                   


<210>  101
<211>  9
<212>  PRT
<213>  Artificial sequence

<220>
<223>  Mutated sequence

<400>  101

Ala Met Glu Lys Phe Ala Tyr Thr Ala 
1               5                   


<210>  102
<211>  9
<212>  PRT
<213>  Artificial sequence

<220>
<223>  Mutated sequence

<400>  102

Ala Thr Glu Lys Phe Ala Tyr Thr Ala 
1               5                   


<210>  103
<211>  9
<212>  PRT
<213>  Artificial sequence

<220>
<223>  Mutated sequence

<400>  103

Ala Leu Glu Lys Phe Ala Tyr Thr Ala 
1               5                   


<210>  104
<211>  9
<212>  PRT
<213>  Artificial sequence

<220>
<223>  Mutated sequence

<400>  104

Ala Ile Glu Lys Pro Ala Tyr Thr Ala 
1               5                   


<210>  105
<211>  9
<212>  PRT
<213>  Artificial sequence

<220>
<223>  Mutated sequence

<400>  105

Ala Met Glu Lys Pro Ala Tyr Thr Ala 
1               5                   


<210>  106
<211>  9
<212>  PRT
<213>  Artificial sequence

<220>
<223>  Mutated sequence

<400>  106

Ala Thr Glu Lys Pro Ala Tyr Thr Ala 
1               5                   


<210>  107
<211>  9
<212>  PRT
<213>  Artificial sequence

<220>
<223>  Mutated sequence

<400>  107

Ala Leu Glu Lys Pro Ala Tyr Thr Ala 
1               5                   


<210>  108
<211>  9
<212>  PRT
<213>  Artificial sequence

<220>
<223>  Mutated sequence

<400>  108

Ala Ile Glu Lys Arg Arg Tyr Thr Ala 
1               5                   


<210>  109
<211>  9
<212>  PRT
<213>  Artificial sequence

<220>
<223>  Mutated sequence

<400>  109

Ala Met Glu Lys Arg Arg Tyr Thr Ala 
1               5                   


<210>  110
<211>  9
<212>  PRT
<213>  Artificial sequence

<220>
<223>  Mutated sequence

<400>  110

Ala Thr Glu Lys Arg Arg Tyr Thr Ala 
1               5                   


<210>  111
<211>  9
<212>  PRT
<213>  Artificial sequence

<220>
<223>  Mutated sequence

<400>  111

Ala Leu Glu Lys Arg Arg Tyr Thr Ala 
1               5                   


<210>  112
<211>  9
<212>  PRT
<213>  Artificial sequence

<220>
<223>  Mutated sequence

<400>  112

Ala Ile Glu Lys Arg Ala Tyr Thr Ala 
1               5                   


<210>  113
<211>  9
<212>  PRT
<213>  Artificial sequence

<220>
<223>  Mutated sequence

<400>  113

Ala Met Glu Lys Arg Ala Tyr Thr Ala 
1               5                   


<210>  114
<211>  9
<212>  PRT
<213>  Artificial sequence

<220>
<223>  Mutated sequence

<400>  114

Ala Thr Glu Lys Arg Ala Tyr Thr Ala 
1               5                   


<210>  115
<211>  9
<212>  PRT
<213>  Artificial sequence

<220>
<223>  Mutated sequence

<400>  115

Ala Leu Glu Lys Arg Ala Tyr Thr Ala 
1               5                   


<210>  116
<211>  9
<212>  PRT
<213>  Artificial sequence

<220>
<223>  Mutated sequence

<400>  116

Ala Ile Glu Lys Arg Phe Tyr Thr Ala 
1               5                   


<210>  117
<211>  9
<212>  PRT
<213>  Artificial sequence

<220>
<223>  Mutated sequence

<400>  117

Ala Met Glu Lys Arg Phe Tyr Thr Ala 
1               5                   


<210>  118
<211>  9
<212>  PRT
<213>  Artificial sequence

<220>
<223>  Mutated sequence

<400>  118

Ala Thr Glu Lys Arg Phe Tyr Thr Ala 
1               5                   


<210>  119
<211>  9
<212>  PRT
<213>  Artificial sequence

<220>
<223>  Mutated sequence

<400>  119

Ala Leu Glu Lys Arg Phe Tyr Thr Ala 
1               5                   


<210>  120
<211>  9
<212>  PRT
<213>  Artificial sequence

<220>
<223>  Mutated sequence

<400>  120

Ala Ile Glu Lys Arg Gly Tyr Thr Ala 
1               5                   


<210>  121
<211>  9
<212>  PRT
<213>  Artificial sequence

<220>
<223>  Mutated sequence

<400>  121

Ala Met Glu Lys Arg Gly Tyr Thr Ala 
1               5                   


<210>  122
<211>  9
<212>  PRT
<213>  Artificial sequence

<220>
<223>  Mutated sequence

<400>  122

Ala Thr Glu Lys Arg Gly Tyr Thr Ala 
1               5                   


<210>  123
<211>  9
<212>  PRT
<213>  Artificial sequence

<220>
<223>  Mutated sequence

<400>  123

Ala Leu Glu Lys Arg Gly Tyr Thr Ala 
1               5                   


<210>  124
<211>  9
<212>  PRT
<213>  Artificial sequence

<220>
<223>  Mutated sequence

<400>  124

Ala Ile Glu Lys Ala Arg Tyr Thr Ala 
1               5                   


<210>  125
<211>  9
<212>  PRT
<213>  Artificial sequence

<220>
<223>  Mutated sequence

<400>  125

Ala Met Glu Lys Ala Arg Tyr Thr Ala 
1               5                   


<210>  126
<211>  9
<212>  PRT
<213>  Artificial sequence

<220>
<223>  Mutated sequence

<400>  126

Ala Thr Glu Lys Ala Arg Tyr Thr Ala 
1               5                   


<210>  127
<211>  9
<212>  PRT
<213>  Artificial sequence

<220>
<223>  Mutated sequence

<400>  127

Ala Leu Glu Lys Ala Arg Tyr Thr Ala 
1               5                   


<210>  128
<211>  9
<212>  PRT
<213>  Artificial sequence

<220>
<223>  Mutated sequence

<400>  128

Ala Ile Glu Lys Ala Ala Tyr Thr Ala 
1               5                   


<210>  129
<211>  9
<212>  PRT
<213>  Artificial sequence

<220>
<223>  Mutated sequence

<400>  129

Ala Met Glu Lys Ala Ala Tyr Thr Ala 
1               5                   


<210>  130
<211>  9
<212>  PRT
<213>  Artificial sequence

<220>
<223>  Mutated sequence

<400>  130

Ala Thr Glu Lys Ala Ala Tyr Thr Ala 
1               5                   


<210>  131
<211>  9
<212>  PRT
<213>  Artificial sequence

<220>
<223>  Mutated sequence

<400>  131

Ala Leu Glu Lys Ala Ala Tyr Thr Ala 
1               5                   


<210>  132
<211>  9
<212>  PRT
<213>  Artificial sequence

<220>
<223>  Mutated sequence

<400>  132

Ala Ile Glu Lys Ala Phe Tyr Thr Ala 
1               5                   


<210>  133
<211>  9
<212>  PRT
<213>  Artificial sequence

<220>
<223>  Mutated sequence

<400>  133

Ala Met Glu Lys Ala Phe Tyr Thr Ala 
1               5                   


<210>  134
<211>  9
<212>  PRT
<213>  Artificial sequence

<220>
<223>  Mutated sequence

<400>  134

Ala Thr Glu Lys Ala Phe Tyr Thr Ala 
1               5                   


<210>  135
<211>  9
<212>  PRT
<213>  Artificial sequence

<220>
<223>  Mutated sequence

<400>  135

Ala Leu Glu Lys Ala Phe Tyr Thr Ala 
1               5                   


<210>  136
<211>  9
<212>  PRT
<213>  Artificial sequence

<220>
<223>  Mutated sequence

<400>  136

Ala Ile Glu Lys Ala Gly Tyr Thr Ala 
1               5                   


<210>  137
<211>  9
<212>  PRT
<213>  Artificial sequence

<220>
<223>  Mutated sequence

<400>  137

Ala Met Glu Lys Ala Gly Tyr Thr Ala 
1               5                   


<210>  138
<211>  9
<212>  PRT
<213>  Artificial sequence

<220>
<223>  Mutated sequence

<400>  138

Ala Thr Glu Lys Ala Gly Tyr Thr Ala 
1               5                   


<210>  139
<211>  9
<212>  PRT
<213>  Artificial sequence

<220>
<223>  Mutated sequence

<400>  139

Ala Leu Glu Lys Ala Gly Tyr Thr Ala 
1               5                   


<210>  140
<211>  9
<212>  PRT
<213>  Artificial sequence

<220>
<223>  Mutated sequence

<400>  140

Ala Ile Glu Lys Gly Arg Tyr Thr Ala 
1               5                   


<210>  141
<211>  9
<212>  PRT
<213>  Artificial sequence

<220>
<223>  Mutated sequence

<400>  141

Ala Met Glu Lys Gly Arg Tyr Thr Ala 
1               5                   


<210>  142
<211>  9
<212>  PRT
<213>  Artificial sequence

<220>
<223>  Mutated sequence

<400>  142

Ala Thr Glu Lys Gly Arg Tyr Thr Ala 
1               5                   


<210>  143
<211>  9
<212>  PRT
<213>  Artificial sequence

<220>
<223>  Mutated sequence

<400>  143

Ala Leu Glu Lys Gly Arg Tyr Thr Ala 
1               5                   


<210>  144
<211>  9
<212>  PRT
<213>  Artificial sequence

<220>
<223>  Mutated sequence

<400>  144

Ala Ile Glu Lys Gly Ala Tyr Thr Ala 
1               5                   


<210>  145
<211>  9
<212>  PRT
<213>  Artificial sequence

<220>
<223>  Mutated sequence

<400>  145

Ala Met Glu Lys Gly Ala Tyr Thr Ala 
1               5                   


<210>  146
<211>  9
<212>  PRT
<213>  Artificial sequence

<220>
<223>  Mutated sequence

<400>  146

Ala Thr Glu Lys Gly Ala Tyr Thr Ala 
1               5                   


<210>  147
<211>  9
<212>  PRT
<213>  Artificial sequence

<220>
<223>  Mutated sequence

<400>  147

Ala Leu Glu Lys Gly Ala Tyr Thr Ala 
1               5                   


<210>  148
<211>  9
<212>  PRT
<213>  Artificial sequence

<220>
<223>  Mutated sequence

<400>  148

Ala Ile Glu Lys Gly Phe Tyr Thr Ala 
1               5                   


<210>  149
<211>  9
<212>  PRT
<213>  Artificial sequence

<220>
<223>  Mutated sequence

<400>  149

Ala Met Glu Lys Gly Phe Tyr Thr Ala 
1               5                   


<210>  150
<211>  9
<212>  PRT
<213>  Artificial sequence

<220>
<223>  Mutated sequence

<400>  150

Ala Thr Glu Lys Gly Phe Tyr Thr Ala 
1               5                   


<210>  151
<211>  9
<212>  PRT
<213>  Artificial sequence

<220>
<223>  Mutated sequence

<400>  151

Ala Leu Glu Lys Gly Phe Tyr Thr Ala 
1               5                   


<210>  152
<211>  9
<212>  PRT
<213>  Artificial sequence

<220>
<223>  Mutated sequence

<400>  152

Ala Ile Glu Lys Gly Gly Tyr Thr Ala 
1               5                   


<210>  153
<211>  9
<212>  PRT
<213>  Artificial sequence

<220>
<223>  Mutated sequence

<400>  153

Ala Met Glu Lys Gly Gly Tyr Thr Ala 
1               5                   


<210>  154
<211>  9
<212>  PRT
<213>  Artificial sequence

<220>
<223>  Mutated sequence

<400>  154

Ala Thr Glu Lys Gly Gly Tyr Thr Ala 
1               5                   


<210>  155
<211>  9
<212>  PRT
<213>  Artificial sequence

<220>
<223>  Mutated sequence

<400>  155

Ala Leu Glu Lys Gly Gly Tyr Thr Ala 
1               5                   


<210>  156
<211>  9
<212>  PRT
<213>  Artificial sequence

<220>
<223>  Mutated sequence

<400>  156

Ala Ile Glu Lys Phe Arg Tyr Thr Ala 
1               5                   


<210>  157
<211>  9
<212>  PRT
<213>  Artificial sequence

<220>
<223>  Mutated sequence

<400>  157

Ala Met Glu Lys Phe Arg Tyr Thr Ala 
1               5                   


<210>  158
<211>  9
<212>  PRT
<213>  Artificial sequence

<220>
<223>  Mutated sequence

<400>  158

Ala Thr Glu Lys Phe Arg Tyr Thr Ala 
1               5                   


<210>  159
<211>  9
<212>  PRT
<213>  Artificial sequence

<220>
<223>  Mutated sequence

<400>  159

Ala Leu Glu Lys Phe Arg Tyr Thr Ala 
1               5                   


<210>  160
<211>  9
<212>  PRT
<213>  Artificial sequence

<220>
<223>  Mutated sequence

<400>  160

Ala Ile Glu Lys Phe Ala Tyr Thr Ala 
1               5                   


<210>  161
<211>  9
<212>  PRT
<213>  Artificial sequence

<220>
<223>  Mutated sequence

<400>  161

Ala Met Glu Lys Phe Ala Tyr Thr Ala 
1               5                   


<210>  162
<211>  9
<212>  PRT
<213>  Artificial sequence

<220>
<223>  Mutated sequence

<400>  162

Ala Thr Glu Lys Phe Ala Tyr Thr Ala 
1               5                   


<210>  163
<211>  9
<212>  PRT
<213>  Artificial sequence

<220>
<223>  Mutated sequence

<400>  163

Ala Leu Glu Lys Phe Ala Tyr Thr Ala 
1               5                   


<210>  164
<211>  9
<212>  PRT
<213>  Artificial sequence

<220>
<223>  Mutated sequence

<400>  164

Ala Ile Glu Lys Phe Phe Tyr Thr Ala 
1               5                   


<210>  165
<211>  9
<212>  PRT
<213>  Artificial sequence

<220>
<223>  Mutated sequence

<400>  165

Ala Met Glu Lys Phe Phe Tyr Thr Ala 
1               5                   


<210>  166
<211>  9
<212>  PRT
<213>  Artificial sequence

<220>
<223>  Mutated sequence

<400>  166

Ala Thr Glu Lys Phe Phe Tyr Thr Ala 
1               5                   


<210>  167
<211>  9
<212>  PRT
<213>  Artificial sequence

<220>
<223>  Mutated sequence

<400>  167

Ala Leu Glu Lys Phe Phe Tyr Thr Ala 
1               5                   


<210>  168
<211>  9
<212>  PRT
<213>  Artificial sequence

<220>
<223>  Mutated sequence

<400>  168

Ala Ile Glu Lys Phe Gly Tyr Thr Ala 
1               5                   


<210>  169
<211>  9
<212>  PRT
<213>  Artificial sequence

<220>
<223>  Mutated sequence

<400>  169

Ala Met Glu Lys Phe Gly Tyr Thr Ala 
1               5                   


<210>  170
<211>  9
<212>  PRT
<213>  Artificial sequence

<220>
<223>  Mutated sequence

<400>  170

Ala Thr Glu Lys Phe Gly Tyr Thr Ala 
1               5                   


<210>  171
<211>  9
<212>  PRT
<213>  Artificial sequence

<220>
<223>  Mutated sequence

<400>  171

Ala Leu Glu Lys Phe Gly Tyr Thr Ala 
1               5                   


<210>  172
<211>  64
<212>  PRT
<213>  Artificial sequence

<220>
<223>  Mutated sequence

<400>  172

Ala Ile Glu Lys Val Thr Gly Ala Leu Lys Ile Asn Asn Leu Arg Leu 
1               5                   10                  15      


Val Thr Leu Glu His Gln Val Leu Val Ile Gly Leu Lys Val Glu Ala 
            20                  25                  30          


Ile Glu Lys Arg Leu Tyr Thr Ala Phe Ala Met Gln Glu Leu Gly Cys 
        35                  40                  45              


Asn Gln Asn Gln Phe Phe Cys Lys Ile Pro Leu Glu Leu Trp Thr Arg 
    50                  55                  60                  


<210>  173
<211>  64
<212>  PRT
<213>  Artificial sequence

<220>
<223>  Mutated sequence

<400>  173

Ala Ile Glu Lys Val Thr Gly Ala Leu Lys Ile Asn Asn Leu Arg Leu 
1               5                   10                  15      


Val Thr Leu Glu His Gln Val Leu Val Ile Gly Leu Lys Val Glu Ala 
            20                  25                  30          


Met Glu Lys Arg Leu Tyr Thr Ala Phe Ala Met Gln Glu Leu Gly Cys 
        35                  40                  45              


Asn Gln Asn Gln Phe Phe Cys Lys Ile Pro Leu Glu Leu Trp Thr Arg 
    50                  55                  60                  


<210>  174
<211>  64
<212>  PRT
<213>  Artificial sequence

<220>
<223>  Mutated sequence

<400>  174

Ala Ile Glu Lys Val Thr Gly Ala Leu Lys Ile Asn Asn Leu Arg Leu 
1               5                   10                  15      


Val Thr Leu Glu His Gln Val Leu Val Ile Gly Leu Lys Val Glu Ala 
            20                  25                  30          


Thr Glu Lys Arg Leu Tyr Thr Ala Phe Ala Met Gln Glu Leu Gly Cys 
        35                  40                  45              


Asn Gln Asn Gln Phe Phe Cys Lys Ile Pro Leu Glu Leu Trp Thr Arg 
    50                  55                  60                  


<210>  175
<211>  64
<212>  PRT
<213>  Artificial sequence

<220>
<223>  Mutated sequence

<400>  175

Ala Ile Glu Lys Val Thr Gly Ala Leu Lys Ile Asn Asn Leu Arg Leu 
1               5                   10                  15      


Val Thr Leu Glu His Gln Val Leu Val Ile Gly Leu Lys Val Glu Ala 
            20                  25                  30          


Leu Glu Lys Arg Leu Tyr Thr Ala Phe Ala Met Gln Glu Leu Gly Cys 
        35                  40                  45              


Asn Gln Asn Gln Phe Phe Cys Lys Ile Pro Leu Glu Leu Trp Thr Arg 
    50                  55                  60                  


<210>  176
<211>  64
<212>  PRT
<213>  Artificial sequence

<220>
<223>  Mutated sequence

<400>  176

Ala Ile Glu Lys Val Thr Gly Ala Leu Lys Ile Asn Asn Leu Arg Leu 
1               5                   10                  15      


Val Thr Leu Glu His Gln Val Leu Val Ile Gly Leu Lys Val Glu Ala 
            20                  25                  30          


Ile Glu Lys Arg Val Tyr Thr Ala Phe Ala Met Gln Glu Leu Gly Cys 
        35                  40                  45              


Asn Gln Asn Gln Phe Phe Cys Lys Ile Pro Leu Glu Leu Trp Thr Arg 
    50                  55                  60                  


<210>  177
<211>  64
<212>  PRT
<213>  Artificial sequence

<220>
<223>  Mutated sequence

<400>  177

Ala Ile Glu Lys Val Thr Gly Ala Leu Lys Ile Asn Asn Leu Arg Leu 
1               5                   10                  15      


Val Thr Leu Glu His Gln Val Leu Val Ile Gly Leu Lys Val Glu Ala 
            20                  25                  30          


Met Glu Lys Arg Val Tyr Thr Ala Phe Ala Met Gln Glu Leu Gly Cys 
        35                  40                  45              


Asn Gln Asn Gln Phe Phe Cys Lys Ile Pro Leu Glu Leu Trp Thr Arg 
    50                  55                  60                  


<210>  178
<211>  64
<212>  PRT
<213>  Artificial sequence

<220>
<223>  Mutated sequence

<400>  178

Ala Ile Glu Lys Val Thr Gly Ala Leu Lys Ile Asn Asn Leu Arg Leu 
1               5                   10                  15      


Val Thr Leu Glu His Gln Val Leu Val Ile Gly Leu Lys Val Glu Ala 
            20                  25                  30          


Thr Glu Lys Arg Val Tyr Thr Ala Phe Ala Met Gln Glu Leu Gly Cys 
        35                  40                  45              


Asn Gln Asn Gln Phe Phe Cys Lys Ile Pro Leu Glu Leu Trp Thr Arg 
    50                  55                  60                  


<210>  179
<211>  64
<212>  PRT
<213>  Artificial sequence

<220>
<223>  Mutated sequence

<400>  179

Ala Ile Glu Lys Val Thr Gly Ala Leu Lys Ile Asn Asn Leu Arg Leu 
1               5                   10                  15      


Val Thr Leu Glu His Gln Val Leu Val Ile Gly Leu Lys Val Glu Ala 
            20                  25                  30          


Leu Glu Lys Arg Val Tyr Thr Ala Phe Ala Met Gln Glu Leu Gly Cys 
        35                  40                  45              


Asn Gln Asn Gln Phe Phe Cys Lys Ile Pro Leu Glu Leu Trp Thr Arg 
    50                  55                  60                  


<210>  180
<211>  64
<212>  PRT
<213>  Artificial sequence

<220>
<223>  Mutated sequence

<400>  180

Ala Ile Glu Lys Val Thr Gly Ala Leu Lys Ile Asn Asn Leu Arg Leu 
1               5                   10                  15      


Val Thr Leu Glu His Gln Val Leu Val Ile Gly Leu Lys Val Glu Ala 
            20                  25                  30          


Ile Glu Lys Arg Ile Tyr Thr Ala Phe Ala Met Gln Glu Leu Gly Cys 
        35                  40                  45              


Asn Gln Asn Gln Phe Phe Cys Lys Ile Pro Leu Glu Leu Trp Thr Arg 
    50                  55                  60                  


<210>  181
<211>  64
<212>  PRT
<213>  Artificial sequence

<220>
<223>  Mutated sequence

<400>  181

Ala Ile Glu Lys Val Thr Gly Ala Leu Lys Ile Asn Asn Leu Arg Leu 
1               5                   10                  15      


Val Thr Leu Glu His Gln Val Leu Val Ile Gly Leu Lys Val Glu Ala 
            20                  25                  30          


Met Glu Lys Arg Ile Tyr Thr Ala Phe Ala Met Gln Glu Leu Gly Cys 
        35                  40                  45              


Asn Gln Asn Gln Phe Phe Cys Lys Ile Pro Leu Glu Leu Trp Thr Arg 
    50                  55                  60                  


<210>  182
<211>  64
<212>  PRT
<213>  Artificial sequence

<220>
<223>  Mutated sequence

<400>  182

Ala Ile Glu Lys Val Thr Gly Ala Leu Lys Ile Asn Asn Leu Arg Leu 
1               5                   10                  15      


Val Thr Leu Glu His Gln Val Leu Val Ile Gly Leu Lys Val Glu Ala 
            20                  25                  30          


Thr Glu Lys Arg Ile Tyr Thr Ala Phe Ala Met Gln Glu Leu Gly Cys 
        35                  40                  45              


Asn Gln Asn Gln Phe Phe Cys Lys Ile Pro Leu Glu Leu Trp Thr Arg 
    50                  55                  60                  


<210>  183
<211>  64
<212>  PRT
<213>  Artificial sequence

<220>
<223>  Mutated sequence

<400>  183

Ala Ile Glu Lys Val Thr Gly Ala Leu Lys Ile Asn Asn Leu Arg Leu 
1               5                   10                  15      


Val Thr Leu Glu His Gln Val Leu Val Ile Gly Leu Lys Val Glu Ala 
            20                  25                  30          


Leu Glu Lys Arg Ile Tyr Thr Ala Phe Ala Met Gln Glu Leu Gly Cys 
        35                  40                  45              


Asn Gln Asn Gln Phe Phe Cys Lys Ile Pro Leu Glu Leu Trp Thr Arg 
    50                  55                  60                  


<210>  184
<211>  64
<212>  PRT
<213>  Artificial sequence

<220>
<223>  Mutated sequence

<400>  184

Ala Ile Glu Lys Val Thr Gly Ala Leu Lys Ile Asn Asn Leu Arg Leu 
1               5                   10                  15      


Val Thr Leu Glu His Gln Val Leu Val Ile Gly Leu Lys Val Glu Ala 
            20                  25                  30          


Ile Glu Lys Gly Leu Tyr Thr Ala Phe Ala Met Gln Glu Leu Gly Cys 
        35                  40                  45              


Asn Gln Asn Gln Phe Phe Cys Lys Ile Pro Leu Glu Leu Trp Thr Arg 
    50                  55                  60                  


<210>  185
<211>  64
<212>  PRT
<213>  Artificial sequence

<220>
<223>  Mutated sequence

<400>  185

Ala Ile Glu Lys Val Thr Gly Ala Leu Lys Ile Asn Asn Leu Arg Leu 
1               5                   10                  15      


Val Thr Leu Glu His Gln Val Leu Val Ile Gly Leu Lys Val Glu Ala 
            20                  25                  30          


Met Glu Lys Gly Leu Tyr Thr Ala Phe Ala Met Gln Glu Leu Gly Cys 
        35                  40                  45              


Asn Gln Asn Gln Phe Phe Cys Lys Ile Pro Leu Glu Leu Trp Thr Arg 
    50                  55                  60                  


<210>  186
<211>  64
<212>  PRT
<213>  Artificial sequence

<220>
<223>  Mutated sequence

<400>  186

Ala Ile Glu Lys Val Thr Gly Ala Leu Lys Ile Asn Asn Leu Arg Leu 
1               5                   10                  15      


Val Thr Leu Glu His Gln Val Leu Val Ile Gly Leu Lys Val Glu Ala 
            20                  25                  30          


Thr Glu Lys Gly Leu Tyr Thr Ala Phe Ala Met Gln Glu Leu Gly Cys 
        35                  40                  45              


Asn Gln Asn Gln Phe Phe Cys Lys Ile Pro Leu Glu Leu Trp Thr Arg 
    50                  55                  60                  


<210>  187
<211>  64
<212>  PRT
<213>  Artificial sequence

<220>
<223>  Mutated sequence

<400>  187

Ala Ile Glu Lys Val Thr Gly Ala Leu Lys Ile Asn Asn Leu Arg Leu 
1               5                   10                  15      


Val Thr Leu Glu His Gln Val Leu Val Ile Gly Leu Lys Val Glu Ala 
            20                  25                  30          


Leu Glu Lys Gly Leu Tyr Thr Ala Phe Ala Met Gln Glu Leu Gly Cys 
        35                  40                  45              


Asn Gln Asn Gln Phe Phe Cys Lys Ile Pro Leu Glu Leu Trp Thr Arg 
    50                  55                  60                  


<210>  188
<211>  64
<212>  PRT
<213>  Artificial sequence

<220>
<223>  Mutated sequence

<400>  188

Ala Ile Glu Lys Val Thr Gly Ala Leu Lys Ile Asn Asn Leu Arg Leu 
1               5                   10                  15      


Val Thr Leu Glu His Gln Val Leu Val Ile Gly Leu Lys Val Glu Ala 
            20                  25                  30          


Ile Glu Lys Gly Val Tyr Thr Ala Phe Ala Met Gln Glu Leu Gly Cys 
        35                  40                  45              


Asn Gln Asn Gln Phe Phe Cys Lys Ile Pro Leu Glu Leu Trp Thr Arg 
    50                  55                  60                  


<210>  189
<211>  64
<212>  PRT
<213>  Artificial sequence

<220>
<223>  Mutated sequence

<400>  189

Ala Ala Ile Glu Lys Val Thr Gly Ala Leu Lys Ile Asn Asn Leu Arg 
1               5                   10                  15      


Leu Val Thr Leu Glu His Gln Val Leu Val Ile Gly Leu Lys Val Glu 
            20                  25                  30          


Met Glu Lys Gly Val Tyr Thr Ala Phe Ala Met Gln Glu Leu Gly Cys 
        35                  40                  45              


Asn Gln Asn Gln Phe Phe Cys Lys Ile Pro Leu Glu Leu Trp Thr Arg 
    50                  55                  60                  


<210>  190
<211>  64
<212>  PRT
<213>  Artificial sequence

<220>
<223>  Mutated sequence

<400>  190

Ala Ile Glu Lys Val Thr Gly Ala Leu Lys Ile Asn Asn Leu Arg Leu 
1               5                   10                  15      


Val Thr Leu Glu His Gln Val Leu Val Ile Gly Leu Lys Val Glu Ala 
            20                  25                  30          


Thr Glu Lys Gly Val Tyr Thr Ala Phe Ala Met Gln Glu Leu Gly Cys 
        35                  40                  45              


Asn Gln Asn Gln Phe Phe Cys Lys Ile Pro Leu Glu Leu Trp Thr Arg 
    50                  55                  60                  


<210>  191
<211>  64
<212>  PRT
<213>  Artificial sequence

<220>
<223>  Mutated sequence

<400>  191

Ala Ile Glu Lys Val Thr Gly Ala Leu Lys Ile Asn Asn Leu Arg Leu 
1               5                   10                  15      


Val Thr Leu Glu His Gln Val Leu Val Ile Gly Leu Lys Val Glu Ala 
            20                  25                  30          


Leu Glu Lys Gly Val Tyr Thr Ala Phe Ala Met Gln Glu Leu Gly Cys 
        35                  40                  45              


Asn Gln Asn Gln Phe Phe Cys Lys Ile Pro Leu Glu Leu Trp Thr Arg 
    50                  55                  60                  


<210>  192
<211>  64
<212>  PRT
<213>  Artificial sequence

<220>
<223>  Mutated sequence

<400>  192

Ala Ile Glu Lys Val Thr Gly Ala Leu Lys Ile Asn Asn Leu Arg Leu 
1               5                   10                  15      


Val Thr Leu Glu His Gln Val Leu Val Ile Gly Leu Lys Val Glu Ala 
            20                  25                  30          


Ile Glu Lys Gly Ile Tyr Thr Ala Phe Ala Met Gln Glu Leu Gly Cys 
        35                  40                  45              


Asn Gln Asn Gln Phe Phe Cys Lys Ile Pro Leu Glu Leu Trp Thr Arg 
    50                  55                  60                  


<210>  193
<211>  64
<212>  PRT
<213>  Artificial sequence

<220>
<223>  Mutated sequence

<400>  193

Ala Ile Glu Lys Val Thr Gly Ala Leu Lys Ile Asn Asn Leu Arg Leu 
1               5                   10                  15      


Val Thr Leu Glu His Gln Val Leu Val Ile Gly Leu Lys Val Glu Ala 
            20                  25                  30          


Met Glu Lys Gly Ile Tyr Thr Ala Phe Ala Met Gln Glu Leu Gly Cys 
        35                  40                  45              


Asn Gln Asn Gln Phe Phe Cys Lys Ile Pro Leu Glu Leu Trp Thr Arg 
    50                  55                  60                  


<210>  194
<211>  64
<212>  PRT
<213>  Artificial sequence

<220>
<223>  Mutated sequence

<400>  194

Ala Ile Glu Lys Val Thr Gly Ala Leu Lys Ile Asn Asn Leu Arg Leu 
1               5                   10                  15      


Val Thr Leu Glu His Gln Val Leu Val Ile Gly Leu Lys Val Glu Ala 
            20                  25                  30          


Thr Glu Lys Gly Ile Tyr Thr Ala Phe Ala Met Gln Glu Leu Gly Cys 
        35                  40                  45              


Asn Gln Asn Gln Phe Phe Cys Lys Ile Pro Leu Glu Leu Trp Thr Arg 
    50                  55                  60                  


<210>  195
<211>  64
<212>  PRT
<213>  Artificial sequence

<220>
<223>  Mutated sequence

<400>  195

Ala Ile Glu Lys Val Thr Gly Ala Leu Lys Ile Asn Asn Leu Arg Leu 
1               5                   10                  15      


Val Thr Leu Glu His Gln Val Leu Val Ile Gly Leu Lys Val Glu Ala 
            20                  25                  30          


Leu Glu Lys Gly Ile Tyr Thr Ala Phe Ala Met Gln Glu Leu Gly Cys 
        35                  40                  45              


Asn Gln Asn Gln Phe Phe Cys Lys Ile Pro Leu Glu Leu Trp Thr Arg 
    50                  55                  60                  


<210>  196
<211>  64
<212>  PRT
<213>  Artificial sequence

<220>
<223>  Mutated sequence

<400>  196

Ala Ile Glu Lys Val Thr Gly Ala Leu Lys Ile Asn Asn Leu Arg Leu 
1               5                   10                  15      


Val Thr Leu Glu His Gln Val Leu Val Ile Gly Leu Lys Val Glu Ala 
            20                  25                  30          


Ile Glu Lys Leu Leu Tyr Thr Ala Phe Ala Met Gln Glu Leu Gly Cys 
        35                  40                  45              


Asn Gln Asn Gln Phe Phe Cys Lys Ile Pro Leu Glu Leu Trp Thr Arg 
    50                  55                  60                  


<210>  197
<211>  64
<212>  PRT
<213>  Artificial sequence

<220>
<223>  Mutated sequence

<400>  197

Ala Ile Glu Lys Val Thr Gly Ala Leu Lys Ile Asn Asn Leu Arg Leu 
1               5                   10                  15      


Val Thr Leu Glu His Gln Val Leu Val Ile Gly Leu Lys Val Glu Ala 
            20                  25                  30          


Met Glu Lys Leu Leu Tyr Thr Ala Phe Ala Met Gln Glu Leu Gly Cys 
        35                  40                  45              


Asn Gln Asn Gln Phe Phe Cys Lys Ile Pro Leu Glu Leu Trp Thr Arg 
    50                  55                  60                  


<210>  198
<211>  64
<212>  PRT
<213>  Artificial sequence

<220>
<223>  Mutated sequence

<400>  198

Ala Ile Glu Lys Val Thr Gly Ala Leu Lys Ile Asn Asn Leu Arg Leu 
1               5                   10                  15      


Val Thr Leu Glu His Gln Val Leu Val Ile Gly Leu Lys Val Glu Ala 
            20                  25                  30          


Thr Glu Lys Leu Leu Tyr Thr Ala Phe Ala Met Gln Glu Leu Gly Cys 
        35                  40                  45              


Asn Gln Asn Gln Phe Phe Cys Lys Ile Pro Leu Glu Leu Trp Thr Arg 
    50                  55                  60                  


<210>  199
<211>  64
<212>  PRT
<213>  Artificial sequence

<220>
<223>  Mutated sequence

<400>  199

Ala Ile Glu Lys Val Thr Gly Ala Leu Lys Ile Asn Asn Leu Arg Leu 
1               5                   10                  15      


Val Thr Leu Glu His Gln Val Leu Val Ile Gly Leu Lys Val Glu Ala 
            20                  25                  30          


Leu Glu Lys Leu Leu Tyr Thr Ala Phe Ala Met Gln Glu Leu Gly Cys 
        35                  40                  45              


Asn Gln Asn Gln Phe Phe Cys Lys Ile Pro Leu Glu Leu Trp Thr Arg 
    50                  55                  60                  


<210>  200
<211>  64
<212>  PRT
<213>  Artificial sequence

<220>
<223>  Mutated sequence

<400>  200

Ala Ile Glu Lys Val Thr Gly Ala Leu Lys Ile Asn Asn Leu Arg Leu 
1               5                   10                  15      


Val Thr Leu Glu His Gln Val Leu Val Ile Gly Leu Lys Val Glu Ala 
            20                  25                  30          


Ile Glu Lys Leu Val Tyr Thr Ala Phe Ala Met Gln Glu Leu Gly Cys 
        35                  40                  45              


Asn Gln Asn Gln Phe Phe Cys Lys Ile Pro Leu Glu Leu Trp Thr Arg 
    50                  55                  60                  


<210>  201
<211>  64
<212>  PRT
<213>  Artificial sequence

<220>
<223>  Mutated sequence

<400>  201

Ala Ile Glu Lys Val Thr Gly Ala Leu Lys Ile Asn Asn Leu Arg Leu 
1               5                   10                  15      


Val Thr Leu Glu His Gln Val Leu Val Ile Gly Leu Lys Val Glu Ala 
            20                  25                  30          


Met Glu Lys Leu Val Tyr Thr Ala Phe Ala Met Gln Glu Leu Gly Cys 
        35                  40                  45              


Asn Gln Asn Gln Phe Phe Cys Lys Ile Pro Leu Glu Leu Trp Thr Arg 
    50                  55                  60                  


<210>  202
<211>  64
<212>  PRT
<213>  Artificial sequence

<220>
<223>  Mutated sequence

<400>  202

Ala Ile Glu Lys Val Thr Gly Ala Leu Lys Ile Asn Asn Leu Arg Leu 
1               5                   10                  15      


Val Thr Leu Glu His Gln Val Leu Val Ile Gly Leu Lys Val Glu Ala 
            20                  25                  30          


Thr Glu Lys Leu Val Tyr Thr Ala Phe Ala Met Gln Glu Leu Gly Cys 
        35                  40                  45              


Asn Gln Asn Gln Phe Phe Cys Lys Ile Pro Leu Glu Leu Trp Thr Arg 
    50                  55                  60                  


<210>  203
<211>  64
<212>  PRT
<213>  Artificial sequence

<220>
<223>  Mutated sequence

<400>  203

Ala Ile Glu Lys Val Thr Gly Ala Leu Lys Ile Asn Asn Leu Arg Leu 
1               5                   10                  15      


Val Thr Leu Glu His Gln Val Leu Val Ile Gly Leu Lys Val Glu Ala 
            20                  25                  30          


Leu Glu Lys Leu Val Tyr Thr Ala Phe Ala Met Gln Glu Leu Gly Cys 
        35                  40                  45              


Asn Gln Asn Gln Phe Phe Cys Lys Ile Pro Leu Glu Leu Trp Thr Arg 
    50                  55                  60                  


<210>  204
<211>  64
<212>  PRT
<213>  Artificial sequence

<220>
<223>  Mutated sequence

<400>  204

Ala Ile Glu Lys Val Thr Gly Ala Leu Lys Ile Asn Asn Leu Arg Leu 
1               5                   10                  15      


Val Thr Leu Glu His Gln Val Leu Val Ile Gly Leu Lys Val Glu Ala 
            20                  25                  30          


Ile Glu Lys Leu Ile Tyr Thr Ala Phe Ala Met Gln Glu Leu Gly Cys 
        35                  40                  45              


Asn Gln Asn Gln Phe Phe Cys Lys Ile Pro Leu Glu Leu Trp Thr Arg 
    50                  55                  60                  


<210>  205
<211>  64
<212>  PRT
<213>  Artificial sequence

<220>
<223>  Mutated sequence

<400>  205

Ala Ile Glu Lys Val Thr Gly Ala Leu Lys Ile Asn Asn Leu Arg Leu 
1               5                   10                  15      


Val Thr Leu Glu His Gln Val Leu Val Ile Gly Leu Lys Val Glu Ala 
            20                  25                  30          


Met Glu Lys Leu Ile Tyr Thr Ala Phe Ala Met Gln Glu Leu Gly Cys 
        35                  40                  45              


Asn Gln Asn Gln Phe Phe Cys Lys Ile Pro Leu Glu Leu Trp Thr Arg 
    50                  55                  60                  


<210>  206
<211>  64
<212>  PRT
<213>  Artificial sequence

<220>
<223>  Mutated sequence

<400>  206

Ala Ile Glu Lys Val Thr Gly Ala Leu Lys Ile Asn Asn Leu Arg Leu 
1               5                   10                  15      


Val Thr Leu Glu His Gln Val Leu Val Ile Gly Leu Lys Val Glu Ala 
            20                  25                  30          


Thr Glu Lys Leu Ile Tyr Thr Ala Phe Ala Met Gln Glu Leu Gly Cys 
        35                  40                  45              


Asn Gln Asn Gln Phe Phe Cys Lys Ile Pro Leu Glu Leu Trp Thr Arg 
    50                  55                  60                  


<210>  207
<211>  64
<212>  PRT
<213>  Artificial sequence

<220>
<223>  Mutated sequence

<400>  207

Ala Ile Glu Lys Val Thr Gly Ala Leu Lys Ile Asn Asn Leu Arg Leu 
1               5                   10                  15      


Val Thr Leu Glu His Gln Val Leu Val Ile Gly Leu Lys Val Glu Ala 
            20                  25                  30          


Leu Glu Lys Leu Ile Tyr Thr Ala Phe Ala Met Gln Glu Leu Gly Cys 
        35                  40                  45              


Asn Gln Asn Gln Phe Phe Cys Lys Ile Pro Leu Glu Leu Trp Thr Arg 
    50                  55                  60                  


<210>  208
<211>  64
<212>  PRT
<213>  Artificial sequence

<220>
<223>  Mutated sequence

<400>  208

Ala Ile Glu Lys Val Thr Gly Ala Leu Lys Ile Asn Asn Leu Arg Leu 
1               5                   10                  15      


Val Thr Leu Glu His Gln Val Leu Val Ile Gly Leu Lys Val Glu Ala 
            20                  25                  30          


Ile Glu Lys Ala Leu Tyr Thr Ala Phe Ala Met Gln Glu Leu Gly Cys 
        35                  40                  45              


Asn Gln Asn Gln Phe Phe Cys Lys Ile Pro Leu Glu Leu Trp Thr Arg 
    50                  55                  60                  


<210>  209
<211>  64
<212>  PRT
<213>  Artificial sequence

<220>
<223>  Mutated sequence

<400>  209

Ala Ile Glu Lys Val Thr Gly Ala Leu Lys Ile Asn Asn Leu Arg Leu 
1               5                   10                  15      


Val Thr Leu Glu His Gln Val Leu Val Ile Gly Leu Lys Val Glu Ala 
            20                  25                  30          


Met Glu Lys Ala Leu Tyr Thr Ala Phe Ala Met Gln Glu Leu Gly Cys 
        35                  40                  45              


Asn Gln Asn Gln Phe Phe Cys Lys Ile Pro Leu Glu Leu Trp Thr Arg 
    50                  55                  60                  


<210>  210
<211>  64
<212>  PRT
<213>  Artificial sequence

<220>
<223>  Mutated sequence

<400>  210

Ala Ile Glu Lys Val Thr Gly Ala Leu Lys Ile Asn Asn Leu Arg Leu 
1               5                   10                  15      


Val Thr Leu Glu His Gln Val Leu Val Ile Gly Leu Lys Val Glu Ala 
            20                  25                  30          


Thr Glu Lys Ala Leu Tyr Thr Ala Phe Ala Met Gln Glu Leu Gly Cys 
        35                  40                  45              


Asn Gln Asn Gln Phe Phe Cys Lys Ile Pro Leu Glu Leu Trp Thr Arg 
    50                  55                  60                  


<210>  211
<211>  64
<212>  PRT
<213>  Artificial sequence

<220>
<223>  Mutated sequence

<400>  211

Ala Ile Glu Lys Val Thr Gly Ala Leu Lys Ile Asn Asn Leu Arg Leu 
1               5                   10                  15      


Val Thr Leu Glu His Gln Val Leu Val Ile Gly Leu Lys Val Glu Ala 
            20                  25                  30          


Leu Glu Lys Ala Leu Tyr Thr Ala Phe Ala Met Gln Glu Leu Gly Cys 
        35                  40                  45              


Asn Gln Asn Gln Phe Phe Cys Lys Ile Pro Leu Glu Leu Trp Thr Arg 
    50                  55                  60                  


<210>  212
<211>  64
<212>  PRT
<213>  Artificial sequence

<220>
<223>  Mutated sequence

<400>  212

Ala Ile Glu Lys Val Thr Gly Ala Leu Lys Ile Asn Asn Leu Arg Leu 
1               5                   10                  15      


Val Thr Leu Glu His Gln Val Leu Val Ile Gly Leu Lys Val Glu Ala 
            20                  25                  30          


Ile Glu Lys Ala Val Tyr Thr Ala Phe Ala Met Gln Glu Leu Gly Cys 
        35                  40                  45              


Asn Gln Asn Gln Phe Phe Cys Lys Ile Pro Leu Glu Leu Trp Thr Arg 
    50                  55                  60                  


<210>  213
<211>  64
<212>  PRT
<213>  Artificial sequence

<220>
<223>  Mutated sequence

<400>  213

Ala Ile Glu Lys Val Thr Gly Ala Leu Lys Ile Asn Asn Leu Arg Leu 
1               5                   10                  15      


Val Thr Leu Glu His Gln Val Leu Val Ile Gly Leu Lys Val Glu Ala 
            20                  25                  30          


Met Glu Lys Ala Val Tyr Thr Ala Phe Ala Met Gln Glu Leu Gly Cys 
        35                  40                  45              


Asn Gln Asn Gln Phe Phe Cys Lys Ile Pro Leu Glu Leu Trp Thr Arg 
    50                  55                  60                  


<210>  214
<211>  64
<212>  PRT
<213>  Artificial sequence

<220>
<223>  Mutated sequence

<400>  214

Ala Ile Glu Lys Val Thr Gly Ala Leu Lys Ile Asn Asn Leu Arg Leu 
1               5                   10                  15      


Val Thr Leu Glu His Gln Val Leu Val Ile Gly Leu Lys Val Glu Ala 
            20                  25                  30          


Thr Glu Lys Ala Val Tyr Thr Ala Phe Ala Met Gln Glu Leu Gly Cys 
        35                  40                  45              


Asn Gln Asn Gln Phe Phe Cys Lys Ile Pro Leu Glu Leu Trp Thr Arg 
    50                  55                  60                  


<210>  215
<211>  64
<212>  PRT
<213>  Artificial sequence

<220>
<223>  Mutated sequence

<400>  215

Ala Ile Glu Lys Val Thr Gly Ala Leu Lys Ile Asn Asn Leu Arg Leu 
1               5                   10                  15      


Val Thr Leu Glu His Gln Val Leu Val Ile Gly Leu Lys Val Glu Ala 
            20                  25                  30          


Leu Glu Lys Ala Val Tyr Thr Ala Phe Ala Met Gln Glu Leu Gly Cys 
        35                  40                  45              


Asn Gln Asn Gln Phe Phe Cys Lys Ile Pro Leu Glu Leu Trp Thr Arg 
    50                  55                  60                  


<210>  216
<211>  64
<212>  PRT
<213>  Artificial sequence

<220>
<223>  Mutated sequence

<400>  216

Ala Ile Glu Lys Val Thr Gly Ala Leu Lys Ile Asn Asn Leu Arg Leu 
1               5                   10                  15      


Val Thr Leu Glu His Gln Val Leu Val Ile Gly Leu Lys Val Glu Ala 
            20                  25                  30          


Ile Glu Lys Ala Ile Tyr Thr Ala Phe Ala Met Gln Glu Leu Gly Cys 
        35                  40                  45              


Asn Gln Asn Gln Phe Phe Cys Lys Ile Pro Leu Glu Leu Trp Thr Arg 
    50                  55                  60                  


<210>  217
<211>  64
<212>  PRT
<213>  Artificial sequence

<220>
<223>  Mutated sequence

<400>  217

Ala Ile Glu Lys Val Thr Gly Ala Leu Lys Ile Asn Asn Leu Arg Leu 
1               5                   10                  15      


Val Thr Leu Glu His Gln Val Leu Val Ile Gly Leu Lys Val Glu Ala 
            20                  25                  30          


Met Glu Lys Ala Ile Tyr Thr Ala Phe Ala Met Gln Glu Leu Gly Cys 
        35                  40                  45              


Asn Gln Asn Gln Phe Phe Cys Lys Ile Pro Leu Glu Leu Trp Thr Arg 
    50                  55                  60                  


<210>  218
<211>  64
<212>  PRT
<213>  Artificial sequence

<220>
<223>  Mutated sequence

<400>  218

Ala Ile Glu Lys Val Thr Gly Ala Leu Lys Ile Asn Asn Leu Arg Leu 
1               5                   10                  15      


Val Thr Leu Glu His Gln Val Leu Val Ile Gly Leu Lys Val Glu Ala 
            20                  25                  30          


Thr Glu Lys Ala Ile Tyr Thr Ala Phe Ala Met Gln Glu Leu Gly Cys 
        35                  40                  45              


Asn Gln Asn Gln Phe Phe Cys Lys Ile Pro Leu Glu Leu Trp Thr Arg 
    50                  55                  60                  


<210>  219
<211>  64
<212>  PRT
<213>  Artificial sequence

<220>
<223>  Mutated sequence

<400>  219

Ala Ile Glu Lys Val Thr Gly Ala Leu Lys Ile Asn Asn Leu Arg Leu 
1               5                   10                  15      


Val Thr Leu Glu His Gln Val Leu Val Ile Gly Leu Lys Val Glu Ala 
            20                  25                  30          


Leu Glu Lys Ala Ile Tyr Thr Ala Phe Ala Met Gln Glu Leu Gly Cys 
        35                  40                  45              


Asn Gln Asn Gln Phe Phe Cys Lys Ile Pro Leu Glu Leu Trp Thr Arg 
    50                  55                  60                  


<210>  220
<211>  64
<212>  PRT
<213>  Artificial sequence

<220>
<223>  Mutated sequence

<400>  220

Ala Ile Glu Lys Val Thr Gly Ala Leu Lys Ile Asn Asn Leu Arg Leu 
1               5                   10                  15      


Val Thr Leu Glu His Gln Val Leu Val Ile Gly Leu Lys Val Glu Ala 
            20                  25                  30          


Ile Glu Lys Phe Arg Tyr Thr Ala Phe Ala Met Gln Glu Leu Gly Cys 
        35                  40                  45              


Asn Gln Asn Gln Phe Phe Cys Lys Ile Pro Leu Glu Leu Trp Thr Arg 
    50                  55                  60                  


<210>  221
<211>  64
<212>  PRT
<213>  Artificial sequence

<220>
<223>  Mutated sequence

<400>  221

Ala Ile Glu Lys Val Thr Gly Ala Leu Lys Ile Asn Asn Leu Arg Leu 
1               5                   10                  15      


Val Thr Leu Glu His Gln Val Leu Val Ile Gly Leu Lys Val Glu Ala 
            20                  25                  30          


Met Glu Lys Phe Arg Tyr Thr Ala Phe Ala Met Gln Glu Leu Gly Cys 
        35                  40                  45              


Asn Gln Asn Gln Phe Phe Cys Lys Ile Pro Leu Glu Leu Trp Thr Arg 
    50                  55                  60                  


<210>  222
<211>  64
<212>  PRT
<213>  Artificial sequence

<220>
<223>  Mutated sequence

<400>  222

Ala Ile Glu Lys Val Thr Gly Ala Leu Lys Ile Asn Asn Leu Arg Leu 
1               5                   10                  15      


Val Thr Leu Glu His Gln Val Leu Val Ile Gly Leu Lys Val Glu Ala 
            20                  25                  30          


Thr Glu Lys Phe Arg Tyr Thr Ala Phe Ala Met Gln Glu Leu Gly Cys 
        35                  40                  45              


Asn Gln Asn Gln Phe Phe Cys Lys Ile Pro Leu Glu Leu Trp Thr Arg 
    50                  55                  60                  


<210>  223
<211>  64
<212>  PRT
<213>  Artificial sequence

<220>
<223>  Mutated sequence

<400>  223

Ala Ile Glu Lys Val Thr Gly Ala Leu Lys Ile Asn Asn Leu Arg Leu 
1               5                   10                  15      


Val Thr Leu Glu His Gln Val Leu Val Ile Gly Leu Lys Val Glu Ala 
            20                  25                  30          


Leu Glu Lys Phe Arg Tyr Thr Ala Phe Ala Met Gln Glu Leu Gly Cys 
        35                  40                  45              


Asn Gln Asn Gln Phe Phe Cys Lys Ile Pro Leu Glu Leu Trp Thr Arg 
    50                  55                  60                  


<210>  224
<211>  64
<212>  PRT
<213>  Artificial sequence

<220>
<223>  Mutated sequence

<400>  224

Ala Ile Glu Lys Val Thr Gly Ala Leu Lys Ile Asn Asn Leu Arg Leu 
1               5                   10                  15      


Val Thr Leu Glu His Gln Val Leu Val Ile Gly Leu Lys Val Glu Ala 
            20                  25                  30          


Ile Glu Lys Pro Arg Tyr Thr Ala Phe Ala Met Gln Glu Leu Gly Cys 
        35                  40                  45              


Asn Gln Asn Gln Phe Phe Cys Lys Ile Pro Leu Glu Leu Trp Thr Arg 
    50                  55                  60                  


<210>  225
<211>  64
<212>  PRT
<213>  Artificial sequence

<220>
<223>  Mutated sequence

<400>  225

Ala Ile Glu Lys Val Thr Gly Ala Leu Lys Ile Asn Asn Leu Arg Leu 
1               5                   10                  15      


Val Thr Leu Glu His Gln Val Leu Val Ile Gly Leu Lys Val Glu Ala 
            20                  25                  30          


Met Glu Lys Pro Arg Tyr Thr Ala Phe Ala Met Gln Glu Leu Gly Cys 
        35                  40                  45              


Asn Gln Asn Gln Phe Phe Cys Lys Ile Pro Leu Glu Leu Trp Thr Arg 
    50                  55                  60                  


<210>  226
<211>  64
<212>  PRT
<213>  Artificial sequence

<220>
<223>  Mutated sequence

<400>  226

Ala Ile Glu Lys Val Thr Gly Ala Leu Lys Ile Asn Asn Leu Arg Leu 
1               5                   10                  15      


Val Thr Leu Glu His Gln Val Leu Val Ile Gly Leu Lys Val Glu Ala 
            20                  25                  30          


Thr Glu Lys Pro Arg Tyr Thr Ala Phe Ala Met Gln Glu Leu Gly Cys 
        35                  40                  45              


Asn Gln Asn Gln Phe Phe Cys Lys Ile Pro Leu Glu Leu Trp Thr Arg 
    50                  55                  60                  


<210>  227
<211>  64
<212>  PRT
<213>  Artificial sequence

<220>
<223>  Mutated sequence

<400>  227

Ala Ile Glu Lys Val Thr Gly Ala Leu Lys Ile Asn Asn Leu Arg Leu 
1               5                   10                  15      


Val Thr Leu Glu His Gln Val Leu Val Ile Gly Leu Lys Val Glu Ala 
            20                  25                  30          


Leu Glu Lys Pro Arg Tyr Thr Ala Phe Ala Met Gln Glu Leu Gly Cys 
        35                  40                  45              


Asn Gln Asn Gln Phe Phe Cys Lys Ile Pro Leu Glu Leu Trp Thr Arg 
    50                  55                  60                  


<210>  228
<211>  64
<212>  PRT
<213>  Artificial sequence

<220>
<223>  Mutated sequence

<400>  228

Ala Ile Glu Lys Val Thr Gly Ala Leu Lys Ile Asn Asn Leu Arg Leu 
1               5                   10                  15      


Val Thr Leu Glu His Gln Val Leu Val Ile Gly Leu Lys Val Glu Ala 
            20                  25                  30          


Ile Glu Lys Phe Gly Tyr Thr Ala Phe Ala Met Gln Glu Leu Gly Cys 
        35                  40                  45              


Asn Gln Asn Gln Phe Phe Cys Lys Ile Pro Leu Glu Leu Trp Thr Arg 
    50                  55                  60                  


<210>  229
<211>  64
<212>  PRT
<213>  Artificial sequence

<220>
<223>  Mutated sequence

<400>  229

Ala Ile Glu Lys Val Thr Gly Ala Leu Lys Ile Asn Asn Leu Arg Leu 
1               5                   10                  15      


Val Thr Leu Glu His Gln Val Leu Val Ile Gly Leu Lys Val Glu Ala 
            20                  25                  30          


Met Glu Lys Phe Gly Tyr Thr Ala Phe Ala Met Gln Glu Leu Gly Cys 
        35                  40                  45              


Asn Gln Asn Gln Phe Phe Cys Lys Ile Pro Leu Glu Leu Trp Thr Arg 
    50                  55                  60                  


<210>  230
<211>  64
<212>  PRT
<213>  Artificial sequence

<220>
<223>  Mutated sequence

<400>  230

Ala Ile Glu Lys Val Thr Gly Ala Leu Lys Ile Asn Asn Leu Arg Leu 
1               5                   10                  15      


Val Thr Leu Glu His Gln Val Leu Val Ile Gly Leu Lys Val Glu Ala 
            20                  25                  30          


Thr Glu Lys Phe Gly Tyr Thr Ala Phe Ala Met Gln Glu Leu Gly Cys 
        35                  40                  45              


Asn Gln Asn Gln Phe Phe Cys Lys Ile Pro Leu Glu Leu Trp Thr Arg 
    50                  55                  60                  


<210>  231
<211>  64
<212>  PRT
<213>  Artificial sequence

<220>
<223>  Mutated sequence

<400>  231

Ala Ile Glu Lys Val Thr Gly Ala Leu Lys Ile Asn Asn Leu Arg Leu 
1               5                   10                  15      


Val Thr Leu Glu His Gln Val Leu Val Ile Gly Leu Lys Val Glu Ala 
            20                  25                  30          


Leu Glu Lys Phe Gly Tyr Thr Ala Phe Ala Met Gln Glu Leu Gly Cys 
        35                  40                  45              


Asn Gln Asn Gln Phe Phe Cys Lys Ile Pro Leu Glu Leu Trp Thr Arg 
    50                  55                  60                  


<210>  232
<211>  64
<212>  PRT
<213>  Artificial sequence

<220>
<223>  Mutated sequence

<400>  232

Ala Ile Glu Lys Val Thr Gly Ala Leu Lys Ile Asn Asn Leu Arg Leu 
1               5                   10                  15      


Val Thr Leu Glu His Gln Val Leu Val Ile Gly Leu Lys Val Glu Ala 
            20                  25                  30          


Ile Glu Lys Pro Gly Tyr Thr Ala Phe Ala Met Gln Glu Leu Gly Cys 
        35                  40                  45              


Asn Gln Asn Gln Phe Phe Cys Lys Ile Pro Leu Glu Leu Trp Thr Arg 
    50                  55                  60                  


<210>  233
<211>  64
<212>  PRT
<213>  Artificial sequence

<220>
<223>  Mutated sequence

<400>  233

Ala Ile Glu Lys Val Thr Gly Ala Leu Lys Ile Asn Asn Leu Arg Leu 
1               5                   10                  15      


Val Thr Leu Glu His Gln Val Leu Val Ile Gly Leu Lys Val Glu Ala 
            20                  25                  30          


Met Glu Lys Pro Gly Tyr Thr Ala Phe Ala Met Gln Glu Leu Gly Cys 
        35                  40                  45              


Asn Gln Asn Gln Phe Phe Cys Lys Ile Pro Leu Glu Leu Trp Thr Arg 
    50                  55                  60                  


<210>  234
<211>  64
<212>  PRT
<213>  Artificial sequence

<220>
<223>  Mutated sequence

<400>  234

Ala Ile Glu Lys Val Thr Gly Ala Leu Lys Ile Asn Asn Leu Arg Leu 
1               5                   10                  15      


Val Thr Leu Glu His Gln Val Leu Val Ile Gly Leu Lys Val Glu Ala 
            20                  25                  30          


Thr Glu Lys Pro Gly Tyr Thr Ala Phe Ala Met Gln Glu Leu Gly Cys 
        35                  40                  45              


Asn Gln Asn Gln Phe Phe Cys Lys Ile Pro Leu Glu Leu Trp Thr Arg 
    50                  55                  60                  


<210>  235
<211>  64
<212>  PRT
<213>  Artificial sequence

<220>
<223>  Mutated sequence

<400>  235

Ala Ile Glu Lys Val Thr Gly Ala Leu Lys Ile Asn Asn Leu Arg Leu 
1               5                   10                  15      


Val Thr Leu Glu His Gln Val Leu Val Ile Gly Leu Lys Val Glu Ala 
            20                  25                  30          


Leu Glu Lys Pro Gly Tyr Thr Ala Phe Ala Met Gln Glu Leu Gly Cys 
        35                  40                  45              


Asn Gln Asn Gln Phe Phe Cys Lys Ile Pro Leu Glu Leu Trp Thr Arg 
    50                  55                  60                  


<210>  236
<211>  64
<212>  PRT
<213>  Artificial sequence

<220>
<223>  Mutated sequence

<400>  236

Ala Ile Glu Lys Val Thr Gly Ala Leu Lys Ile Asn Asn Leu Arg Leu 
1               5                   10                  15      


Val Thr Leu Glu His Gln Val Leu Val Ile Gly Leu Lys Val Glu Ala 
            20                  25                  30          


Ile Glu Lys Phe Phe Tyr Thr Ala Phe Ala Met Gln Glu Leu Gly Cys 
        35                  40                  45              


Asn Gln Asn Gln Phe Phe Cys Lys Ile Pro Leu Glu Leu Trp Thr Arg 
    50                  55                  60                  


<210>  237
<211>  64
<212>  PRT
<213>  Artificial sequence

<220>
<223>  Mutated sequence

<400>  237

Ala Ile Glu Lys Val Thr Gly Ala Leu Lys Ile Asn Asn Leu Arg Leu 
1               5                   10                  15      


Val Thr Leu Glu His Gln Val Leu Val Ile Gly Leu Lys Val Glu Ala 
            20                  25                  30          


Met Glu Lys Phe Phe Tyr Thr Ala Phe Ala Met Gln Glu Leu Gly Cys 
        35                  40                  45              


Asn Gln Asn Gln Phe Phe Cys Lys Ile Pro Leu Glu Leu Trp Thr Arg 
    50                  55                  60                  


<210>  238
<211>  64
<212>  PRT
<213>  Artificial sequence

<220>
<223>  Mutated sequence

<400>  238

Ala Ile Glu Lys Val Thr Gly Ala Leu Lys Ile Asn Asn Leu Arg Leu 
1               5                   10                  15      


Val Thr Leu Glu His Gln Val Leu Val Ile Gly Leu Lys Val Glu Ala 
            20                  25                  30          


Thr Glu Lys Phe Phe Tyr Thr Ala Phe Ala Met Gln Glu Leu Gly Cys 
        35                  40                  45              


Asn Gln Asn Gln Phe Phe Cys Lys Ile Pro Leu Glu Leu Trp Thr Arg 
    50                  55                  60                  


<210>  239
<211>  64
<212>  PRT
<213>  Artificial sequence

<220>
<223>  Mutated sequence

<400>  239

Ala Ile Glu Lys Val Thr Gly Ala Leu Lys Ile Asn Asn Leu Arg Leu 
1               5                   10                  15      


Val Thr Leu Glu His Gln Val Leu Val Ile Gly Leu Lys Val Glu Ala 
            20                  25                  30          


Leu Glu Lys Phe Phe Tyr Thr Ala Phe Ala Met Gln Glu Leu Gly Cys 
        35                  40                  45              


Asn Gln Asn Gln Phe Phe Cys Lys Ile Pro Leu Glu Leu Trp Thr Arg 
    50                  55                  60                  


<210>  240
<211>  64
<212>  PRT
<213>  Artificial sequence

<220>
<223>  Mutated sequence

<400>  240

Ala Ile Glu Lys Val Thr Gly Ala Leu Lys Ile Asn Asn Leu Arg Leu 
1               5                   10                  15      


Val Thr Leu Glu His Gln Val Leu Val Ile Gly Leu Lys Val Glu Ala 
            20                  25                  30          


Ile Glu Lys Pro Phe Tyr Thr Ala Phe Ala Met Gln Glu Leu Gly Cys 
        35                  40                  45              


Asn Gln Asn Gln Phe Phe Cys Lys Ile Pro Leu Glu Leu Trp Thr Arg 
    50                  55                  60                  


<210>  241
<211>  64
<212>  PRT
<213>  Artificial sequence

<220>
<223>  Mutated sequence

<400>  241

Ala Ile Glu Lys Val Thr Gly Ala Leu Lys Ile Asn Asn Leu Arg Leu 
1               5                   10                  15      


Val Thr Leu Glu His Gln Val Leu Val Ile Gly Leu Lys Val Glu Ala 
            20                  25                  30          


Met Glu Lys Pro Phe Tyr Thr Ala Phe Ala Met Gln Glu Leu Gly Cys 
        35                  40                  45              


Asn Gln Asn Gln Phe Phe Cys Lys Ile Pro Leu Glu Leu Trp Thr Arg 
    50                  55                  60                  


<210>  242
<211>  64
<212>  PRT
<213>  Artificial sequence

<220>
<223>  Mutated sequence

<400>  242

Ala Ile Glu Lys Val Thr Gly Ala Leu Lys Ile Asn Asn Leu Arg Leu 
1               5                   10                  15      


Val Thr Leu Glu His Gln Val Leu Val Ile Gly Leu Lys Val Glu Ala 
            20                  25                  30          


Thr Glu Lys Pro Phe Tyr Thr Ala Phe Ala Met Gln Glu Leu Gly Cys 
        35                  40                  45              


Asn Gln Asn Gln Phe Phe Cys Lys Ile Pro Leu Glu Leu Trp Thr Arg 
    50                  55                  60                  


<210>  243
<211>  64
<212>  PRT
<213>  Artificial sequence

<220>
<223>  Mutated sequence

<400>  243

Ala Ile Glu Lys Val Thr Gly Ala Leu Lys Ile Asn Asn Leu Arg Leu 
1               5                   10                  15      


Val Thr Leu Glu His Gln Val Leu Val Ile Gly Leu Lys Val Glu Ala 
            20                  25                  30          


Leu Glu Lys Pro Phe Tyr Thr Ala Phe Ala Met Gln Glu Leu Gly Cys 
        35                  40                  45              


Asn Gln Asn Gln Phe Phe Cys Lys Ile Pro Leu Glu Leu Trp Thr Arg 
    50                  55                  60                  


<210>  244
<211>  64
<212>  PRT
<213>  Artificial sequence

<220>
<223>  Mutated sequence

<400>  244

Ala Ile Glu Lys Val Thr Gly Ala Leu Lys Ile Asn Asn Leu Arg Leu 
1               5                   10                  15      


Val Thr Leu Glu His Gln Val Leu Val Ile Gly Leu Lys Val Glu Ala 
            20                  25                  30          


Ile Glu Lys Phe Ala Tyr Thr Ala Phe Ala Met Gln Glu Leu Gly Cys 
        35                  40                  45              


Asn Gln Asn Gln Phe Phe Cys Lys Ile Pro Leu Glu Leu Trp Thr Arg 
    50                  55                  60                  


<210>  245
<211>  64
<212>  PRT
<213>  Artificial sequence

<220>
<223>  Mutated sequence

<400>  245

Ala Ile Glu Lys Val Thr Gly Ala Leu Lys Ile Asn Asn Leu Arg Leu 
1               5                   10                  15      


Val Thr Leu Glu His Gln Val Leu Val Ile Gly Leu Lys Val Glu Ala 
            20                  25                  30          


Met Glu Lys Phe Ala Tyr Thr Ala Phe Ala Met Gln Glu Leu Gly Cys 
        35                  40                  45              


Asn Gln Asn Gln Phe Phe Cys Lys Ile Pro Leu Glu Leu Trp Thr Arg 
    50                  55                  60                  


<210>  246
<211>  64
<212>  PRT
<213>  Artificial sequence

<220>
<223>  Mutated sequence

<400>  246

Ala Ile Glu Lys Val Thr Gly Ala Leu Lys Ile Asn Asn Leu Arg Leu 
1               5                   10                  15      


Val Thr Leu Glu His Gln Val Leu Val Ile Gly Leu Lys Val Glu Ala 
            20                  25                  30          


Thr Glu Lys Phe Ala Tyr Thr Ala Phe Ala Met Gln Glu Leu Gly Cys 
        35                  40                  45              


Asn Gln Asn Gln Phe Phe Cys Lys Ile Pro Leu Glu Leu Trp Thr Arg 
    50                  55                  60                  


<210>  247
<211>  64
<212>  PRT
<213>  Artificial sequence

<220>
<223>  Mutated sequence

<400>  247

Ala Ile Glu Lys Val Thr Gly Ala Leu Lys Ile Asn Asn Leu Arg Leu 
1               5                   10                  15      


Val Thr Leu Glu His Gln Val Leu Val Ile Gly Leu Lys Val Glu Ala 
            20                  25                  30          


Leu Glu Lys Phe Ala Tyr Thr Ala Phe Ala Met Gln Glu Leu Gly Cys 
        35                  40                  45              


Asn Gln Asn Gln Phe Phe Cys Lys Ile Pro Leu Glu Leu Trp Thr Arg 
    50                  55                  60                  


<210>  248
<211>  64
<212>  PRT
<213>  Artificial sequence

<220>
<223>  Mutated sequence

<400>  248

Ala Ile Glu Lys Val Thr Gly Ala Leu Lys Ile Asn Asn Leu Arg Leu 
1               5                   10                  15      


Val Thr Leu Glu His Gln Val Leu Val Ile Gly Leu Lys Val Glu Ala 
            20                  25                  30          


Ile Glu Lys Pro Ala Tyr Thr Ala Phe Ala Met Gln Glu Leu Gly Cys 
        35                  40                  45              


Asn Gln Asn Gln Phe Phe Cys Lys Ile Pro Leu Glu Leu Trp Thr Arg 
    50                  55                  60                  


<210>  249
<211>  64
<212>  PRT
<213>  Artificial sequence

<220>
<223>  Mutated sequence

<400>  249

Ala Ile Glu Lys Val Thr Gly Ala Leu Lys Ile Asn Asn Leu Arg Leu 
1               5                   10                  15      


Val Thr Leu Glu His Gln Val Leu Val Ile Gly Leu Lys Val Glu Ala 
            20                  25                  30          


Met Glu Lys Pro Ala Tyr Thr Ala Phe Ala Met Gln Glu Leu Gly Cys 
        35                  40                  45              


Asn Gln Asn Gln Phe Phe Cys Lys Ile Pro Leu Glu Leu Trp Thr Arg 
    50                  55                  60                  


<210>  250
<211>  64
<212>  PRT
<213>  Artificial sequence

<220>
<223>  Mutated sequence

<400>  250

Ala Ile Glu Lys Val Thr Gly Ala Leu Lys Ile Asn Asn Leu Arg Leu 
1               5                   10                  15      


Val Thr Leu Glu His Gln Val Leu Val Ile Gly Leu Lys Val Glu Ala 
            20                  25                  30          


Thr Glu Lys Pro Ala Tyr Thr Ala Phe Ala Met Gln Glu Leu Gly Cys 
        35                  40                  45              


Asn Gln Asn Gln Phe Phe Cys Lys Ile Pro Leu Glu Leu Trp Thr Arg 
    50                  55                  60                  


<210>  251
<211>  64
<212>  PRT
<213>  Artificial sequence

<220>
<223>  Mutated sequence

<400>  251

Ala Ile Glu Lys Val Thr Gly Ala Leu Lys Ile Asn Asn Leu Arg Leu 
1               5                   10                  15      


Val Thr Leu Glu His Gln Val Leu Val Ile Gly Leu Lys Val Glu Ala 
            20                  25                  30          


Leu Glu Lys Pro Ala Tyr Thr Ala Phe Ala Met Gln Glu Leu Gly Cys 
        35                  40                  45              


Asn Gln Asn Gln Phe Phe Cys Lys Ile Pro Leu Glu Leu Trp Thr Arg 
    50                  55                  60                  


<210>  252
<211>  64
<212>  PRT
<213>  Artificial sequence

<220>
<223>  Mutated sequence

<400>  252

Ala Ile Glu Lys Val Thr Gly Ala Leu Lys Ile Asn Asn Leu Arg Leu 
1               5                   10                  15      


Val Thr Leu Glu His Gln Val Leu Val Ile Gly Leu Lys Val Glu Ala 
            20                  25                  30          


Ile Glu Lys Arg Arg Tyr Thr Ala Phe Ala Met Gln Glu Leu Gly Cys 
        35                  40                  45              


Asn Gln Asn Gln Phe Phe Cys Lys Ile Pro Leu Glu Leu Trp Thr Arg 
    50                  55                  60                  


<210>  253
<211>  64
<212>  PRT
<213>  Artificial sequence

<220>
<223>  Mutated sequence

<400>  253

Ala Ile Glu Lys Val Thr Gly Ala Leu Lys Ile Asn Asn Leu Arg Leu 
1               5                   10                  15      


Val Thr Leu Glu His Gln Val Leu Val Ile Gly Leu Lys Val Glu Ala 
            20                  25                  30          


Met Glu Lys Arg Arg Tyr Thr Ala Phe Ala Met Gln Glu Leu Gly Cys 
        35                  40                  45              


Asn Gln Asn Gln Phe Phe Cys Lys Ile Pro Leu Glu Leu Trp Thr Arg 
    50                  55                  60                  


<210>  254
<211>  64
<212>  PRT
<213>  Artificial sequence

<220>
<223>  Mutated sequence

<400>  254

Ala Ile Glu Lys Val Thr Gly Ala Leu Lys Ile Asn Asn Leu Arg Leu 
1               5                   10                  15      


Val Thr Leu Glu His Gln Val Leu Val Ile Gly Leu Lys Val Glu Ala 
            20                  25                  30          


Thr Glu Lys Arg Arg Tyr Thr Ala Phe Ala Met Gln Glu Leu Gly Cys 
        35                  40                  45              


Asn Gln Asn Gln Phe Phe Cys Lys Ile Pro Leu Glu Leu Trp Thr Arg 
    50                  55                  60                  


<210>  255
<211>  64
<212>  PRT
<213>  Artificial sequence

<220>
<223>  Mutated sequence

<400>  255

Ala Ile Glu Lys Val Thr Gly Ala Leu Lys Ile Asn Asn Leu Arg Leu 
1               5                   10                  15      


Val Thr Leu Glu His Gln Val Leu Val Ile Gly Leu Lys Val Glu Ala 
            20                  25                  30          


Leu Glu Lys Arg Arg Tyr Thr Ala Phe Ala Met Gln Glu Leu Gly Cys 
        35                  40                  45              


Asn Gln Asn Gln Phe Phe Cys Lys Ile Pro Leu Glu Leu Trp Thr Arg 
    50                  55                  60                  


<210>  256
<211>  64
<212>  PRT
<213>  Artificial sequence

<220>
<223>  Mutated sequence

<400>  256

Ala Ile Glu Lys Val Thr Gly Ala Leu Lys Ile Asn Asn Leu Arg Leu 
1               5                   10                  15      


Val Thr Leu Glu His Gln Val Leu Val Ile Gly Leu Lys Val Glu Ala 
            20                  25                  30          


Ile Glu Lys Arg Ala Tyr Thr Ala Phe Ala Met Gln Glu Leu Gly Cys 
        35                  40                  45              


Asn Gln Asn Gln Phe Phe Cys Lys Ile Pro Leu Glu Leu Trp Thr Arg 
    50                  55                  60                  


<210>  257
<211>  64
<212>  PRT
<213>  Artificial sequence

<220>
<223>  Mutated sequence

<400>  257

Ala Ile Glu Lys Val Thr Gly Ala Leu Lys Ile Asn Asn Leu Arg Leu 
1               5                   10                  15      


Val Thr Leu Glu His Gln Val Leu Val Ile Gly Leu Lys Val Glu Ala 
            20                  25                  30          


Met Glu Lys Arg Ala Tyr Thr Ala Phe Ala Met Gln Glu Leu Gly Cys 
        35                  40                  45              


Asn Gln Asn Gln Phe Phe Cys Lys Ile Pro Leu Glu Leu Trp Thr Arg 
    50                  55                  60                  


<210>  258
<211>  64
<212>  PRT
<213>  Artificial sequence

<220>
<223>  Mutated sequence

<400>  258

Ala Ile Glu Lys Val Thr Gly Ala Leu Lys Ile Asn Asn Leu Arg Leu 
1               5                   10                  15      


Val Thr Leu Glu His Gln Val Leu Val Ile Gly Leu Lys Val Glu Ala 
            20                  25                  30          


Thr Glu Lys Arg Ala Tyr Thr Ala Phe Ala Met Gln Glu Leu Gly Cys 
        35                  40                  45              


Asn Gln Asn Gln Phe Phe Cys Lys Ile Pro Leu Glu Leu Trp Thr Arg 
    50                  55                  60                  


<210>  259
<211>  64
<212>  PRT
<213>  Artificial sequence

<220>
<223>  Mutated sequence

<400>  259

Ala Ile Glu Lys Val Thr Gly Ala Leu Lys Ile Asn Asn Leu Arg Leu 
1               5                   10                  15      


Val Thr Leu Glu His Gln Val Leu Val Ile Gly Leu Lys Val Glu Ala 
            20                  25                  30          


Leu Glu Lys Arg Ala Tyr Thr Ala Phe Ala Met Gln Glu Leu Gly Cys 
        35                  40                  45              


Asn Gln Asn Gln Phe Phe Cys Lys Ile Pro Leu Glu Leu Trp Thr Arg 
    50                  55                  60                  


<210>  260
<211>  64
<212>  PRT
<213>  Artificial sequence

<220>
<223>  Mutated sequence

<400>  260

Ala Ile Glu Lys Val Thr Gly Ala Leu Lys Ile Asn Asn Leu Arg Leu 
1               5                   10                  15      


Val Thr Leu Glu His Gln Val Leu Val Ile Gly Leu Lys Val Glu Ala 
            20                  25                  30          


Ile Glu Lys Arg Phe Tyr Thr Ala Phe Ala Met Gln Glu Leu Gly Cys 
        35                  40                  45              


Asn Gln Asn Gln Phe Phe Cys Lys Ile Pro Leu Glu Leu Trp Thr Arg 
    50                  55                  60                  


<210>  261
<211>  64
<212>  PRT
<213>  Artificial sequence

<220>
<223>  Mutated sequence

<400>  261

Ala Ile Glu Lys Val Thr Gly Ala Leu Lys Ile Asn Asn Leu Arg Leu 
1               5                   10                  15      


Val Thr Leu Glu His Gln Val Leu Val Ile Gly Leu Lys Val Glu Ala 
            20                  25                  30          


Met Glu Lys Arg Phe Tyr Thr Ala Phe Ala Met Gln Glu Leu Gly Cys 
        35                  40                  45              


Asn Gln Asn Gln Phe Phe Cys Lys Ile Pro Leu Glu Leu Trp Thr Arg 
    50                  55                  60                  


<210>  262
<211>  64
<212>  PRT
<213>  Artificial sequence

<220>
<223>  Mutated sequence

<400>  262

Ala Ile Glu Lys Val Thr Gly Ala Leu Lys Ile Asn Asn Leu Arg Leu 
1               5                   10                  15      


Val Thr Leu Glu His Gln Val Leu Val Ile Gly Leu Lys Val Glu Ala 
            20                  25                  30          


Thr Glu Lys Arg Phe Tyr Thr Ala Phe Ala Met Gln Glu Leu Gly Cys 
        35                  40                  45              


Asn Gln Asn Gln Phe Phe Cys Lys Ile Pro Leu Glu Leu Trp Thr Arg 
    50                  55                  60                  


<210>  263
<211>  64
<212>  PRT
<213>  Artificial sequence

<220>
<223>  Mutated sequence

<400>  263

Ala Ile Glu Lys Val Thr Gly Ala Leu Lys Ile Asn Asn Leu Arg Leu 
1               5                   10                  15      


Val Thr Leu Glu His Gln Val Leu Val Ile Gly Leu Lys Val Glu Ala 
            20                  25                  30          


Leu Glu Lys Arg Phe Tyr Thr Ala Phe Ala Met Gln Glu Leu Gly Cys 
        35                  40                  45              


Asn Gln Asn Gln Phe Phe Cys Lys Ile Pro Leu Glu Leu Trp Thr Arg 
    50                  55                  60                  


<210>  264
<211>  64
<212>  PRT
<213>  Artificial sequence

<220>
<223>  Mutated sequence

<400>  264

Ala Ile Glu Lys Val Thr Gly Ala Leu Lys Ile Asn Asn Leu Arg Leu 
1               5                   10                  15      


Val Thr Leu Glu His Gln Val Leu Val Ile Gly Leu Lys Val Glu Ala 
            20                  25                  30          


Ile Glu Lys Arg Gly Tyr Thr Ala Phe Ala Met Gln Glu Leu Gly Cys 
        35                  40                  45              


Asn Gln Asn Gln Phe Phe Cys Lys Ile Pro Leu Glu Leu Trp Thr Arg 
    50                  55                  60                  


<210>  265
<211>  64
<212>  PRT
<213>  Artificial sequence

<220>
<223>  Mutated sequence

<400>  265

Ala Ile Glu Lys Val Thr Gly Ala Leu Lys Ile Asn Asn Leu Arg Leu 
1               5                   10                  15      


Val Thr Leu Glu His Gln Val Leu Val Ile Gly Leu Lys Val Glu Ala 
            20                  25                  30          


Met Glu Lys Arg Gly Tyr Thr Ala Phe Ala Met Gln Glu Leu Gly Cys 
        35                  40                  45              


Asn Gln Asn Gln Phe Phe Cys Lys Ile Pro Leu Glu Leu Trp Thr Arg 
    50                  55                  60                  


<210>  266
<211>  64
<212>  PRT
<213>  Artificial sequence

<220>
<223>  Mutated sequence

<400>  266

Ala Ile Glu Lys Val Thr Gly Ala Leu Lys Ile Asn Asn Leu Arg Leu 
1               5                   10                  15      


Val Thr Leu Glu His Gln Val Leu Val Ile Gly Leu Lys Val Glu Ala 
            20                  25                  30          


Thr Glu Lys Arg Gly Tyr Thr Ala Phe Ala Met Gln Glu Leu Gly Cys 
        35                  40                  45              


Asn Gln Asn Gln Phe Phe Cys Lys Ile Pro Leu Glu Leu Trp Thr Arg 
    50                  55                  60                  


<210>  267
<211>  64
<212>  PRT
<213>  Artificial sequence

<220>
<223>  Mutated sequence

<400>  267

Ala Ile Glu Lys Val Thr Gly Ala Leu Lys Ile Asn Asn Leu Arg Leu 
1               5                   10                  15      


Val Thr Leu Glu His Gln Val Leu Val Ile Gly Leu Lys Val Glu Ala 
            20                  25                  30          


Leu Glu Lys Arg Gly Tyr Thr Ala Phe Ala Met Gln Glu Leu Gly Cys 
        35                  40                  45              


Asn Gln Asn Gln Phe Phe Cys Lys Ile Pro Leu Glu Leu Trp Thr Arg 
    50                  55                  60                  


<210>  268
<211>  64
<212>  PRT
<213>  Artificial sequence

<220>
<223>  Mutated sequence

<400>  268

Ala Ile Glu Lys Val Thr Gly Ala Leu Lys Ile Asn Asn Leu Arg Leu 
1               5                   10                  15      


Val Thr Leu Glu His Gln Val Leu Val Ile Gly Leu Lys Val Glu Ala 
            20                  25                  30          


Ile Glu Lys Ala Arg Tyr Thr Ala Phe Ala Met Gln Glu Leu Gly Cys 
        35                  40                  45              


Asn Gln Asn Gln Phe Phe Cys Lys Ile Pro Leu Glu Leu Trp Thr Arg 
    50                  55                  60                  


<210>  269
<211>  64
<212>  PRT
<213>  Artificial sequence

<220>
<223>  Mutated sequence

<400>  269

Ala Ile Glu Lys Val Thr Gly Ala Leu Lys Ile Asn Asn Leu Arg Leu 
1               5                   10                  15      


Val Thr Leu Glu His Gln Val Leu Val Ile Gly Leu Lys Val Glu Ala 
            20                  25                  30          


Met Glu Lys Ala Arg Tyr Thr Ala Phe Ala Met Gln Glu Leu Gly Cys 
        35                  40                  45              


Asn Gln Asn Gln Phe Phe Cys Lys Ile Pro Leu Glu Leu Trp Thr Arg 
    50                  55                  60                  


<210>  270
<211>  64
<212>  PRT
<213>  Artificial sequence

<220>
<223>  Mutated sequence

<400>  270

Ala Ile Glu Lys Val Thr Gly Ala Leu Lys Ile Asn Asn Leu Arg Leu 
1               5                   10                  15      


Val Thr Leu Glu His Gln Val Leu Val Ile Gly Leu Lys Val Glu Ala 
            20                  25                  30          


Thr Glu Lys Ala Arg Tyr Thr Ala Phe Ala Met Gln Glu Leu Gly Cys 
        35                  40                  45              


Asn Gln Asn Gln Phe Phe Cys Lys Ile Pro Leu Glu Leu Trp Thr Arg 
    50                  55                  60                  


<210>  271
<211>  64
<212>  PRT
<213>  Artificial sequence

<220>
<223>  Mutated sequence

<400>  271

Ala Ile Glu Lys Val Thr Gly Ala Leu Lys Ile Asn Asn Leu Arg Leu 
1               5                   10                  15      


Val Thr Leu Glu His Gln Val Leu Val Ile Gly Leu Lys Val Glu Ala 
            20                  25                  30          


Leu Glu Lys Ala Arg Tyr Thr Ala Phe Ala Met Gln Glu Leu Gly Cys 
        35                  40                  45              


Asn Gln Asn Gln Phe Phe Cys Lys Ile Pro Leu Glu Leu Trp Thr Arg 
    50                  55                  60                  


<210>  272
<211>  64
<212>  PRT
<213>  Artificial sequence

<220>
<223>  Mutated sequence

<400>  272

Ala Ile Glu Lys Val Thr Gly Ala Leu Lys Ile Asn Asn Leu Arg Leu 
1               5                   10                  15      


Val Thr Leu Glu His Gln Val Leu Val Ile Gly Leu Lys Val Glu Ala 
            20                  25                  30          


Ile Glu Lys Ala Ala Tyr Thr Ala Phe Ala Met Gln Glu Leu Gly Cys 
        35                  40                  45              


Asn Gln Asn Gln Phe Phe Cys Lys Ile Pro Leu Glu Leu Trp Thr Arg 
    50                  55                  60                  


<210>  273
<211>  64
<212>  PRT
<213>  Artificial sequence

<220>
<223>  Mutated sequence

<400>  273

Ala Ile Glu Lys Val Thr Gly Ala Leu Lys Ile Asn Asn Leu Arg Leu 
1               5                   10                  15      


Val Thr Leu Glu His Gln Val Leu Val Ile Gly Leu Lys Val Glu Ala 
            20                  25                  30          


Met Glu Lys Ala Ala Tyr Thr Ala Phe Ala Met Gln Glu Leu Gly Cys 
        35                  40                  45              


Asn Gln Asn Gln Phe Phe Cys Lys Ile Pro Leu Glu Leu Trp Thr Arg 
    50                  55                  60                  


<210>  274
<211>  64
<212>  PRT
<213>  Artificial sequence

<220>
<223>  Mutated sequence

<400>  274

Ala Ile Glu Lys Val Thr Gly Ala Leu Lys Ile Asn Asn Leu Arg Leu 
1               5                   10                  15      


Val Thr Leu Glu His Gln Val Leu Val Ile Gly Leu Lys Val Glu Ala 
            20                  25                  30          


Thr Glu Lys Ala Ala Tyr Thr Ala Phe Ala Met Gln Glu Leu Gly Cys 
        35                  40                  45              


Asn Gln Asn Gln Phe Phe Cys Lys Ile Pro Leu Glu Leu Trp Thr Arg 
    50                  55                  60                  


<210>  275
<211>  64
<212>  PRT
<213>  Artificial sequence

<220>
<223>  Mutated sequence

<400>  275

Ala Ile Glu Lys Val Thr Gly Ala Leu Lys Ile Asn Asn Leu Arg Leu 
1               5                   10                  15      


Val Thr Leu Glu His Gln Val Leu Val Ile Gly Leu Lys Val Glu Ala 
            20                  25                  30          


Leu Glu Lys Ala Ala Tyr Thr Ala Phe Ala Met Gln Glu Leu Gly Cys 
        35                  40                  45              


Asn Gln Asn Gln Phe Phe Cys Lys Ile Pro Leu Glu Leu Trp Thr Arg 
    50                  55                  60                  


<210>  276
<211>  64
<212>  PRT
<213>  Artificial sequence

<220>
<223>  Mutated sequence

<400>  276

Ala Ile Glu Lys Val Thr Gly Ala Leu Lys Ile Asn Asn Leu Arg Leu 
1               5                   10                  15      


Val Thr Leu Glu His Gln Val Leu Val Ile Gly Leu Lys Val Glu Ala 
            20                  25                  30          


Ile Glu Lys Ala Phe Tyr Thr Ala Phe Ala Met Gln Glu Leu Gly Cys 
        35                  40                  45              


Asn Gln Asn Gln Phe Phe Cys Lys Ile Pro Leu Glu Leu Trp Thr Arg 
    50                  55                  60                  


<210>  277
<211>  64
<212>  PRT
<213>  Artificial sequence

<220>
<223>  Mutated sequence

<400>  277

Ala Ile Glu Lys Val Thr Gly Ala Leu Lys Ile Asn Asn Leu Arg Leu 
1               5                   10                  15      


Val Thr Leu Glu His Gln Val Leu Val Ile Gly Leu Lys Val Glu Ala 
            20                  25                  30          


Met Glu Lys Ala Phe Tyr Thr Ala Phe Ala Met Gln Glu Leu Gly Cys 
        35                  40                  45              


Asn Gln Asn Gln Phe Phe Cys Lys Ile Pro Leu Glu Leu Trp Thr Arg 
    50                  55                  60                  


<210>  278
<211>  64
<212>  PRT
<213>  Artificial sequence

<220>
<223>  Mutated sequence

<400>  278

Ala Ile Glu Lys Val Thr Gly Ala Leu Lys Ile Asn Asn Leu Arg Leu 
1               5                   10                  15      


Val Thr Leu Glu His Gln Val Leu Val Ile Gly Leu Lys Val Glu Ala 
            20                  25                  30          


Thr Glu Lys Ala Phe Tyr Thr Ala Phe Ala Met Gln Glu Leu Gly Cys 
        35                  40                  45              


Asn Gln Asn Gln Phe Phe Cys Lys Ile Pro Leu Glu Leu Trp Thr Arg 
    50                  55                  60                  


<210>  279
<211>  64
<212>  PRT
<213>  Artificial sequence

<220>
<223>  Mutated sequence

<400>  279

Ala Ile Glu Lys Val Thr Gly Ala Leu Lys Ile Asn Asn Leu Arg Leu 
1               5                   10                  15      


Val Thr Leu Glu His Gln Val Leu Val Ile Gly Leu Lys Val Glu Ala 
            20                  25                  30          


Leu Glu Lys Ala Phe Tyr Thr Ala Phe Ala Met Gln Glu Leu Gly Cys 
        35                  40                  45              


Asn Gln Asn Gln Phe Phe Cys Lys Ile Pro Leu Glu Leu Trp Thr Arg 
    50                  55                  60                  


<210>  280
<211>  64
<212>  PRT
<213>  Artificial sequence

<220>
<223>  Mutated sequence

<400>  280

Ala Ile Glu Lys Val Thr Gly Ala Leu Lys Ile Asn Asn Leu Arg Leu 
1               5                   10                  15      


Val Thr Leu Glu His Gln Val Leu Val Ile Gly Leu Lys Val Glu Ala 
            20                  25                  30          


Ile Glu Lys Ala Gly Tyr Thr Ala Phe Ala Met Gln Glu Leu Gly Cys 
        35                  40                  45              


Asn Gln Asn Gln Phe Phe Cys Lys Ile Pro Leu Glu Leu Trp Thr Arg 
    50                  55                  60                  


<210>  281
<211>  64
<212>  PRT
<213>  Artificial sequence

<220>
<223>  Mutated sequence

<400>  281

Ala Ile Glu Lys Val Thr Gly Ala Leu Lys Ile Asn Asn Leu Arg Leu 
1               5                   10                  15      


Val Thr Leu Glu His Gln Val Leu Val Ile Gly Leu Lys Val Glu Ala 
            20                  25                  30          


Met Glu Lys Ala Gly Tyr Thr Ala Phe Ala Met Gln Glu Leu Gly Cys 
        35                  40                  45              


Asn Gln Asn Gln Phe Phe Cys Lys Ile Pro Leu Glu Leu Trp Thr Arg 
    50                  55                  60                  


<210>  282
<211>  64
<212>  PRT
<213>  Artificial sequence

<220>
<223>  Mutated sequence

<400>  282

Ala Ile Glu Lys Val Thr Gly Ala Leu Lys Ile Asn Asn Leu Arg Leu 
1               5                   10                  15      


Val Thr Leu Glu His Gln Val Leu Val Ile Gly Leu Lys Val Glu Ala 
            20                  25                  30          


Thr Glu Lys Ala Gly Tyr Thr Ala Phe Ala Met Gln Glu Leu Gly Cys 
        35                  40                  45              


Asn Gln Asn Gln Phe Phe Cys Lys Ile Pro Leu Glu Leu Trp Thr Arg 
    50                  55                  60                  


<210>  283
<211>  64
<212>  PRT
<213>  Artificial sequence

<220>
<223>  Mutated sequence

<400>  283

Ala Ile Glu Lys Val Thr Gly Ala Leu Lys Ile Asn Asn Leu Arg Leu 
1               5                   10                  15      


Val Thr Leu Glu His Gln Val Leu Val Ile Gly Leu Lys Val Glu Ala 
            20                  25                  30          


Leu Glu Lys Ala Gly Tyr Thr Ala Phe Ala Met Gln Glu Leu Gly Cys 
        35                  40                  45              


Asn Gln Asn Gln Phe Phe Cys Lys Ile Pro Leu Glu Leu Trp Thr Arg 
    50                  55                  60                  


<210>  284
<211>  64
<212>  PRT
<213>  Artificial sequence

<220>
<223>  Mutated sequence

<400>  284

Ala Ile Glu Lys Val Thr Gly Ala Leu Lys Ile Asn Asn Leu Arg Leu 
1               5                   10                  15      


Val Thr Leu Glu His Gln Val Leu Val Ile Gly Leu Lys Val Glu Ala 
            20                  25                  30          


Ile Glu Lys Gly Arg Tyr Thr Ala Phe Ala Met Gln Glu Leu Gly Cys 
        35                  40                  45              


Asn Gln Asn Gln Phe Phe Cys Lys Ile Pro Leu Glu Leu Trp Thr Arg 
    50                  55                  60                  


<210>  285
<211>  64
<212>  PRT
<213>  Artificial sequence

<220>
<223>  Mutated sequence

<400>  285

Ala Ile Glu Lys Val Thr Gly Ala Leu Lys Ile Asn Asn Leu Arg Leu 
1               5                   10                  15      


Val Thr Leu Glu His Gln Val Leu Val Ile Gly Leu Lys Val Glu Ala 
            20                  25                  30          


Met Glu Lys Gly Arg Tyr Thr Ala Phe Ala Met Gln Glu Leu Gly Cys 
        35                  40                  45              


Asn Gln Asn Gln Phe Phe Cys Lys Ile Pro Leu Glu Leu Trp Thr Arg 
    50                  55                  60                  


<210>  286
<211>  64
<212>  PRT
<213>  Artificial sequence

<220>
<223>  Mutated sequence

<400>  286

Ala Ile Glu Lys Val Thr Gly Ala Leu Lys Ile Asn Asn Leu Arg Leu 
1               5                   10                  15      


Val Thr Leu Glu His Gln Val Leu Val Ile Gly Leu Lys Val Glu Ala 
            20                  25                  30          


Thr Glu Lys Gly Arg Tyr Thr Ala Phe Ala Met Gln Glu Leu Gly Cys 
        35                  40                  45              


Asn Gln Asn Gln Phe Phe Cys Lys Ile Pro Leu Glu Leu Trp Thr Arg 
    50                  55                  60                  


<210>  287
<211>  64
<212>  PRT
<213>  Artificial sequence

<220>
<223>  Mutated sequence

<400>  287

Ala Ile Glu Lys Val Thr Gly Ala Leu Lys Ile Asn Asn Leu Arg Leu 
1               5                   10                  15      


Val Thr Leu Glu His Gln Val Leu Val Ile Gly Leu Lys Val Glu Ala 
            20                  25                  30          


Leu Glu Lys Gly Arg Tyr Thr Ala Phe Ala Met Gln Glu Leu Gly Cys 
        35                  40                  45              


Asn Gln Asn Gln Phe Phe Cys Lys Ile Pro Leu Glu Leu Trp Thr Arg 
    50                  55                  60                  


<210>  288
<211>  64
<212>  PRT
<213>  Artificial sequence

<220>
<223>  Mutated sequence

<400>  288

Ala Ile Glu Lys Val Thr Gly Ala Leu Lys Ile Asn Asn Leu Arg Leu 
1               5                   10                  15      


Val Thr Leu Glu His Gln Val Leu Val Ile Gly Leu Lys Val Glu Ala 
            20                  25                  30          


Ile Glu Lys Gly Ala Tyr Thr Ala Phe Ala Met Gln Glu Leu Gly Cys 
        35                  40                  45              


Asn Gln Asn Gln Phe Phe Cys Lys Ile Pro Leu Glu Leu Trp Thr Arg 
    50                  55                  60                  


<210>  289
<211>  64
<212>  PRT
<213>  Artificial sequence

<220>
<223>  Mutated sequence

<400>  289

Ala Ile Glu Lys Val Thr Gly Ala Leu Lys Ile Asn Asn Leu Arg Leu 
1               5                   10                  15      


Val Thr Leu Glu His Gln Val Leu Val Ile Gly Leu Lys Val Glu Ala 
            20                  25                  30          


Met Glu Lys Gly Ala Tyr Thr Ala Phe Ala Met Gln Glu Leu Gly Cys 
        35                  40                  45              


Asn Gln Asn Gln Phe Phe Cys Lys Ile Pro Leu Glu Leu Trp Thr Arg 
    50                  55                  60                  


<210>  290
<211>  64
<212>  PRT
<213>  Artificial sequence

<220>
<223>  Mutated sequence

<400>  290

Ala Ile Glu Lys Val Thr Gly Ala Leu Lys Ile Asn Asn Leu Arg Leu 
1               5                   10                  15      


Val Thr Leu Glu His Gln Val Leu Val Ile Gly Leu Lys Val Glu Ala 
            20                  25                  30          


Thr Glu Lys Gly Ala Tyr Thr Ala Phe Ala Met Gln Glu Leu Gly Cys 
        35                  40                  45              


Asn Gln Asn Gln Phe Phe Cys Lys Ile Pro Leu Glu Leu Trp Thr Arg 
    50                  55                  60                  


<210>  291
<211>  64
<212>  PRT
<213>  Artificial sequence

<220>
<223>  Mutated sequence

<400>  291

Ala Ile Glu Lys Val Thr Gly Ala Leu Lys Ile Asn Asn Leu Arg Leu 
1               5                   10                  15      


Val Thr Leu Glu His Gln Val Leu Val Ile Gly Leu Lys Val Glu Ala 
            20                  25                  30          


Leu Glu Lys Gly Ala Tyr Thr Ala Phe Ala Met Gln Glu Leu Gly Cys 
        35                  40                  45              


Asn Gln Asn Gln Phe Phe Cys Lys Ile Pro Leu Glu Leu Trp Thr Arg 
    50                  55                  60                  


<210>  292
<211>  64
<212>  PRT
<213>  Artificial sequence

<220>
<223>  Mutated sequence

<400>  292

Ala Ile Glu Lys Val Thr Gly Ala Leu Lys Ile Asn Asn Leu Arg Leu 
1               5                   10                  15      


Val Thr Leu Glu His Gln Val Leu Val Ile Gly Leu Lys Val Glu Ala 
            20                  25                  30          


Ile Glu Lys Gly Phe Tyr Thr Ala Phe Ala Met Gln Glu Leu Gly Cys 
        35                  40                  45              


Asn Gln Asn Gln Phe Phe Cys Lys Ile Pro Leu Glu Leu Trp Thr Arg 
    50                  55                  60                  


<210>  293
<211>  64
<212>  PRT
<213>  Artificial sequence

<220>
<223>  Mutated sequence

<400>  293

Ala Ile Glu Lys Val Thr Gly Ala Leu Lys Ile Asn Asn Leu Arg Leu 
1               5                   10                  15      


Val Thr Leu Glu His Gln Val Leu Val Ile Gly Leu Lys Val Glu Ala 
            20                  25                  30          


Met Glu Lys Gly Phe Tyr Thr Ala Phe Ala Met Gln Glu Leu Gly Cys 
        35                  40                  45              


Asn Gln Asn Gln Phe Phe Cys Lys Ile Pro Leu Glu Leu Trp Thr Arg 
    50                  55                  60                  


<210>  294
<211>  64
<212>  PRT
<213>  Artificial sequence

<220>
<223>  Mutated sequence

<400>  294

Ala Ile Glu Lys Val Thr Gly Ala Leu Lys Ile Asn Asn Leu Arg Leu 
1               5                   10                  15      


Val Thr Leu Glu His Gln Val Leu Val Ile Gly Leu Lys Val Glu Ala 
            20                  25                  30          


Thr Glu Lys Gly Phe Tyr Thr Ala Phe Ala Met Gln Glu Leu Gly Cys 
        35                  40                  45              


Asn Gln Asn Gln Phe Phe Cys Lys Ile Pro Leu Glu Leu Trp Thr Arg 
    50                  55                  60                  


<210>  295
<211>  64
<212>  PRT
<213>  Artificial sequence

<220>
<223>  Mutated sequence

<400>  295

Ala Ile Glu Lys Val Thr Gly Ala Leu Lys Ile Asn Asn Leu Arg Leu 
1               5                   10                  15      


Val Thr Leu Glu His Gln Val Leu Val Ile Gly Leu Lys Val Glu Ala 
            20                  25                  30          


Leu Glu Lys Gly Phe Tyr Thr Ala Phe Ala Met Gln Glu Leu Gly Cys 
        35                  40                  45              


Asn Gln Asn Gln Phe Phe Cys Lys Ile Pro Leu Glu Leu Trp Thr Arg 
    50                  55                  60                  


<210>  296
<211>  64
<212>  PRT
<213>  Artificial sequence

<220>
<223>  Mutated sequence

<400>  296

Ala Ile Glu Lys Val Thr Gly Ala Leu Lys Ile Asn Asn Leu Arg Leu 
1               5                   10                  15      


Val Thr Leu Glu His Gln Val Leu Val Ile Gly Leu Lys Val Glu Ala 
            20                  25                  30          


Ile Glu Lys Gly Gly Tyr Thr Ala Phe Ala Met Gln Glu Leu Gly Cys 
        35                  40                  45              


Asn Gln Asn Gln Phe Phe Cys Lys Ile Pro Leu Glu Leu Trp Thr Arg 
    50                  55                  60                  


<210>  297
<211>  64
<212>  PRT
<213>  Artificial sequence

<220>
<223>  Mutated sequence

<400>  297

Ala Ile Glu Lys Val Thr Gly Ala Leu Lys Ile Asn Asn Leu Arg Leu 
1               5                   10                  15      


Val Thr Leu Glu His Gln Val Leu Val Ile Gly Leu Lys Val Glu Ala 
            20                  25                  30          


Met Glu Lys Gly Gly Tyr Thr Ala Phe Ala Met Gln Glu Leu Gly Cys 
        35                  40                  45              


Asn Gln Asn Gln Phe Phe Cys Lys Ile Pro Leu Glu Leu Trp Thr Arg 
    50                  55                  60                  


<210>  298
<211>  64
<212>  PRT
<213>  Artificial sequence

<220>
<223>  Mutated sequence

<400>  298

Ala Ile Glu Lys Val Thr Gly Ala Leu Lys Ile Asn Asn Leu Arg Leu 
1               5                   10                  15      


Val Thr Leu Glu His Gln Val Leu Val Ile Gly Leu Lys Val Glu Ala 
            20                  25                  30          


Thr Glu Lys Gly Gly Tyr Thr Ala Phe Ala Met Gln Glu Leu Gly Cys 
        35                  40                  45              


Asn Gln Asn Gln Phe Phe Cys Lys Ile Pro Leu Glu Leu Trp Thr Arg 
    50                  55                  60                  


<210>  299
<211>  64
<212>  PRT
<213>  Artificial sequence

<220>
<223>  Mutated sequence

<400>  299

Ala Ile Glu Lys Val Thr Gly Ala Leu Lys Ile Asn Asn Leu Arg Leu 
1               5                   10                  15      


Val Thr Leu Glu His Gln Val Leu Val Ile Gly Leu Lys Val Glu Ala 
            20                  25                  30          


Leu Glu Lys Gly Gly Tyr Thr Ala Phe Ala Met Gln Glu Leu Gly Cys 
        35                  40                  45              


Asn Gln Asn Gln Phe Phe Cys Lys Ile Pro Leu Glu Leu Trp Thr Arg 
    50                  55                  60                  


<210>  300
<211>  64
<212>  PRT
<213>  Artificial sequence

<220>
<223>  Mutated sequence

<400>  300

Ala Ile Glu Lys Val Thr Gly Ala Leu Lys Ile Asn Asn Leu Arg Leu 
1               5                   10                  15      


Val Thr Leu Glu His Gln Val Leu Val Ile Gly Leu Lys Val Glu Ala 
            20                  25                  30          


Ile Glu Lys Phe Arg Tyr Thr Ala Phe Ala Met Gln Glu Leu Gly Cys 
        35                  40                  45              


Asn Gln Asn Gln Phe Phe Cys Lys Ile Pro Leu Glu Leu Trp Thr Arg 
    50                  55                  60                  


<210>  301
<211>  64
<212>  PRT
<213>  Artificial sequence

<220>
<223>  Mutated sequence

<400>  301

Ala Ile Glu Lys Val Thr Gly Ala Leu Lys Ile Asn Asn Leu Arg Leu 
1               5                   10                  15      


Val Thr Leu Glu His Gln Val Leu Val Ile Gly Leu Lys Val Glu Ala 
            20                  25                  30          


Met Glu Lys Phe Arg Tyr Thr Ala Phe Ala Met Gln Glu Leu Gly Cys 
        35                  40                  45              


Asn Gln Asn Gln Phe Phe Cys Lys Ile Pro Leu Glu Leu Trp Thr Arg 
    50                  55                  60                  


<210>  302
<211>  64
<212>  PRT
<213>  Artificial sequence

<220>
<223>  Mutated sequence

<400>  302

Ala Ile Glu Lys Val Thr Gly Ala Leu Lys Ile Asn Asn Leu Arg Leu 
1               5                   10                  15      


Val Thr Leu Glu His Gln Val Leu Val Ile Gly Leu Lys Val Glu Ala 
            20                  25                  30          


Thr Glu Lys Phe Arg Tyr Thr Ala Phe Ala Met Gln Glu Leu Gly Cys 
        35                  40                  45              


Asn Gln Asn Gln Phe Phe Cys Lys Ile Pro Leu Glu Leu Trp Thr Arg 
    50                  55                  60                  


<210>  303
<211>  64
<212>  PRT
<213>  Artificial sequence

<220>
<223>  Mutated sequence

<400>  303

Ala Ile Glu Lys Val Thr Gly Ala Leu Lys Ile Asn Asn Leu Arg Leu 
1               5                   10                  15      


Val Thr Leu Glu His Gln Val Leu Val Ile Gly Leu Lys Val Glu Ala 
            20                  25                  30          


Leu Glu Lys Phe Arg Tyr Thr Ala Phe Ala Met Gln Glu Leu Gly Cys 
        35                  40                  45              


Asn Gln Asn Gln Phe Phe Cys Lys Ile Pro Leu Glu Leu Trp Thr Arg 
    50                  55                  60                  


<210>  304
<211>  64
<212>  PRT
<213>  Artificial sequence

<220>
<223>  Mutated sequence

<400>  304

Ala Ile Glu Lys Val Thr Gly Ala Leu Lys Ile Asn Asn Leu Arg Leu 
1               5                   10                  15      


Val Thr Leu Glu His Gln Val Leu Val Ile Gly Leu Lys Val Glu Ala 
            20                  25                  30          


Ile Glu Lys Phe Ala Tyr Thr Ala Phe Ala Met Gln Glu Leu Gly Cys 
        35                  40                  45              


Asn Gln Asn Gln Phe Phe Cys Lys Ile Pro Leu Glu Leu Trp Thr Arg 
    50                  55                  60                  


<210>  305
<211>  64
<212>  PRT
<213>  Artificial sequence

<220>
<223>  Mutated sequence

<400>  305

Ala Ile Glu Lys Val Thr Gly Ala Leu Lys Ile Asn Asn Leu Arg Leu 
1               5                   10                  15      


Val Thr Leu Glu His Gln Val Leu Val Ile Gly Leu Lys Val Glu Ala 
            20                  25                  30          


Met Glu Lys Phe Ala Tyr Thr Ala Phe Ala Met Gln Glu Leu Gly Cys 
        35                  40                  45              


Asn Gln Asn Gln Phe Phe Cys Lys Ile Pro Leu Glu Leu Trp Thr Arg 
    50                  55                  60                  


<210>  306
<211>  64
<212>  PRT
<213>  Artificial sequence

<220>
<223>  Mutated sequence

<400>  306

Ala Ile Glu Lys Val Thr Gly Ala Leu Lys Ile Asn Asn Leu Arg Leu 
1               5                   10                  15      


Val Thr Leu Glu His Gln Val Leu Val Ile Gly Leu Lys Val Glu Ala 
            20                  25                  30          


Thr Glu Lys Phe Ala Tyr Thr Ala Phe Ala Met Gln Glu Leu Gly Cys 
        35                  40                  45              


Asn Gln Asn Gln Phe Phe Cys Lys Ile Pro Leu Glu Leu Trp Thr Arg 
    50                  55                  60                  


<210>  307
<211>  64
<212>  PRT
<213>  Artificial sequence

<220>
<223>  Mutated sequence

<400>  307

Ala Ile Glu Lys Val Thr Gly Ala Leu Lys Ile Asn Asn Leu Arg Leu 
1               5                   10                  15      


Val Thr Leu Glu His Gln Val Leu Val Ile Gly Leu Lys Val Glu Ala 
            20                  25                  30          


Leu Glu Lys Phe Ala Tyr Thr Ala Phe Ala Met Gln Glu Leu Gly Cys 
        35                  40                  45              


Asn Gln Asn Gln Phe Phe Cys Lys Ile Pro Leu Glu Leu Trp Thr Arg 
    50                  55                  60                  


<210>  308
<211>  64
<212>  PRT
<213>  Artificial sequence

<220>
<223>  Mutated sequence

<400>  308

Ala Ile Glu Lys Val Thr Gly Ala Leu Lys Ile Asn Asn Leu Arg Leu 
1               5                   10                  15      


Val Thr Leu Glu His Gln Val Leu Val Ile Gly Leu Lys Val Glu Ala 
            20                  25                  30          


Ile Glu Lys Phe Phe Tyr Thr Ala Phe Ala Met Gln Glu Leu Gly Cys 
        35                  40                  45              


Asn Gln Asn Gln Phe Phe Cys Lys Ile Pro Leu Glu Leu Trp Thr Arg 
    50                  55                  60                  


<210>  309
<211>  64
<212>  PRT
<213>  Artificial sequence

<220>
<223>  Mutated sequence

<400>  309

Ala Ile Glu Lys Val Thr Gly Ala Leu Lys Ile Asn Asn Leu Arg Leu 
1               5                   10                  15      


Val Thr Leu Glu His Gln Val Leu Val Ile Gly Leu Lys Val Glu Ala 
            20                  25                  30          


Met Glu Lys Phe Phe Tyr Thr Ala Phe Ala Met Gln Glu Leu Gly Cys 
        35                  40                  45              


Asn Gln Asn Gln Phe Phe Cys Lys Ile Pro Leu Glu Leu Trp Thr Arg 
    50                  55                  60                  


<210>  310
<211>  64
<212>  PRT
<213>  Artificial sequence

<220>
<223>  Mutated sequence

<400>  310

Ala Ile Glu Lys Val Thr Gly Ala Leu Lys Ile Asn Asn Leu Arg Leu 
1               5                   10                  15      


Val Thr Leu Glu His Gln Val Leu Val Ile Gly Leu Lys Val Glu Ala 
            20                  25                  30          


Thr Glu Lys Phe Phe Tyr Thr Ala Phe Ala Met Gln Glu Leu Gly Cys 
        35                  40                  45              


Asn Gln Asn Gln Phe Phe Cys Lys Ile Pro Leu Glu Leu Trp Thr Arg 
    50                  55                  60                  


<210>  311
<211>  64
<212>  PRT
<213>  Artificial sequence

<220>
<223>  Mutated sequence

<400>  311

Ala Ile Glu Lys Val Thr Gly Ala Leu Lys Ile Asn Asn Leu Arg Leu 
1               5                   10                  15      


Val Thr Leu Glu His Gln Val Leu Val Ile Gly Leu Lys Val Glu Ala 
            20                  25                  30          


Leu Glu Lys Phe Phe Tyr Thr Ala Phe Ala Met Gln Glu Leu Gly Cys 
        35                  40                  45              


Asn Gln Asn Gln Phe Phe Cys Lys Ile Pro Leu Glu Leu Trp Thr Arg 
    50                  55                  60                  


<210>  312
<211>  64
<212>  PRT
<213>  Artificial sequence

<220>
<223>  Mutated sequence

<400>  312

Ala Ile Glu Lys Val Thr Gly Ala Leu Lys Ile Asn Asn Leu Arg Leu 
1               5                   10                  15      


Val Thr Leu Glu His Gln Val Leu Val Ile Gly Leu Lys Val Glu Ala 
            20                  25                  30          


Ile Glu Lys Phe Gly Tyr Thr Ala Phe Ala Met Gln Glu Leu Gly Cys 
        35                  40                  45              


Asn Gln Asn Gln Phe Phe Cys Lys Ile Pro Leu Glu Leu Trp Thr Arg 
    50                  55                  60                  


<210>  313
<211>  64
<212>  PRT
<213>  Artificial sequence

<220>
<223>  Mutated sequence

<400>  313

Ala Ile Glu Lys Val Thr Gly Ala Leu Lys Ile Asn Asn Leu Arg Leu 
1               5                   10                  15      


Val Thr Leu Glu His Gln Val Leu Val Ile Gly Leu Lys Val Glu Ala 
            20                  25                  30          


Met Glu Lys Phe Gly Tyr Thr Ala Phe Ala Met Gln Glu Leu Gly Cys 
        35                  40                  45              


Asn Gln Asn Gln Phe Phe Cys Lys Ile Pro Leu Glu Leu Trp Thr Arg 
    50                  55                  60                  


<210>  314
<211>  64
<212>  PRT
<213>  Artificial sequence

<220>
<223>  Mutated sequence

<400>  314

Ala Ile Glu Lys Val Thr Gly Ala Leu Lys Ile Asn Asn Leu Arg Leu 
1               5                   10                  15      


Val Thr Leu Glu His Gln Val Leu Val Ile Gly Leu Lys Val Glu Ala 
            20                  25                  30          


Thr Glu Lys Phe Gly Tyr Thr Ala Phe Ala Met Gln Glu Leu Gly Cys 
        35                  40                  45              


Asn Gln Asn Gln Phe Phe Cys Lys Ile Pro Leu Glu Leu Trp Thr Arg 
    50                  55                  60                  


<210>  315
<211>  64
<212>  PRT
<213>  Artificial sequence

<220>
<223>  Mutated sequence

<400>  315

Ala Ile Glu Lys Val Thr Gly Ala Leu Lys Ile Asn Asn Leu Arg Leu 
1               5                   10                  15      


Val Thr Leu Glu His Gln Val Leu Val Ile Gly Leu Lys Val Glu Ala 
            20                  25                  30          


Leu Glu Lys Phe Gly Tyr Thr Ala Phe Ala Met Gln Glu Leu Gly Cys 
        35                  40                  45              


Asn Gln Asn Gln Phe Phe Cys Lys Ile Pro Leu Glu Leu Trp Thr Arg 
    50                  55                  60                  


<210>  316
<211>  16
<212>  PRT
<213>  Artificial sequence

<220>
<223>  Mutated sequence


<220>
<221>  misc_feature
<222>  (1)..(5)
<223>  Xaa is any naturally occurring amino acid or is mutated

<220>
<221>  misc_feature
<222>  (6)..(6)
<223>  Xaa is Val or Ile

<220>
<221>  misc_feature
<222>  (7)..(7)
<223>  Xaa is Glu or Arg

<220>
<221>  misc_feature
<222>  (9)..(9)
<223>  Xaa is Ile or Met or Thr or Ile

<220>
<221>  misc_feature
<222>  (10)..(14)
<223>  Xaa is any naturally occurring amino acid or is mutated

<400>  316

Xaa Xaa Xaa Xaa Xaa Xaa Xaa Ala Xaa Xaa Xaa Xaa Xaa Xaa Thr Ala 
1               5                   10                  15      


<210>  317
<211>  856
<212>  PRT
<213>  Artificial sequence

<220>
<223>  Mutated sequence

<400>  317

Met Ala Glu Gly Phe Ala Ala Asn Arg Gln Trp Ile Gly Pro Glu Glu 
1               5                   10                  15      


Ala Glu Glu Leu Leu Asp Phe Asp Ile Ala Thr Gln Met Ser Glu Glu 
            20                  25                  30          


Gly Pro Leu Asn Pro Gly Val Asn Pro Phe Arg Val Pro Gly Ile Thr 
        35                  40                  45              


Glu Lys Glu Lys Gln Asn Tyr Cys Asn Ile Leu Gln Pro Lys Leu Gln 
    50                  55                  60                  


Asp Leu Arg Asn Glu Ile Gln Glu Val Lys Leu Glu Glu Gly Asn Ala 
65                  70                  75                  80  


Gly Lys Phe Arg Arg Ala Arg Phe Leu Arg Tyr Ser Asp Glu Arg Val 
                85                  90                  95      


Leu Ser Leu Val His Ala Phe Ile Gly Tyr Cys Ile Tyr Leu Gly Asn 
            100                 105                 110         


Arg Asn Lys Leu Gly Ser Leu Arg His Asp Ile Asp Ile Glu Ala Pro 
        115                 120                 125             


Gln Glu Glu Cys Tyr Asn Asn Arg Glu Lys Gly Thr Thr Asp Asn Ile 
    130                 135                 140                 


Lys Tyr Gly Arg Arg Cys Cys Leu Gly Thr Val Thr Leu Tyr Leu Ile 
145                 150                 155                 160 


Leu Phe Thr Gly Val Ile Val Tyr Ser Gln Thr Ala Gly Ala Gln Val 
                165                 170                 175     


Val Trp Arg Leu Pro Pro Leu Val Val Pro Val Glu Glu Ser Glu Ile 
            180                 185                 190         


Ile Phe Trp Asp Cys Trp Ala Pro Glu Glu Pro Ala Cys Gln Asp Phe 
        195                 200                 205             


Leu Gly Ala Met Ile His Leu Lys Ala Lys Thr Asn Ile Ser Ile Arg 
    210                 215                 220                 


Glu Gly Pro Thr Leu Gly Asn Trp Ala Arg Glu Ile Trp Ala Thr Leu 
225                 230                 235                 240 


Phe Lys Lys Ala Thr Arg Gln Cys Arg Arg Gly Arg Ile Trp Lys Arg 
                245                 250                 255     


Trp Asn Glu Thr Ile Thr Gly Pro Ser Gly Cys Ala Asn Asn Thr Cys 
            260                 265                 270         


Tyr Asn Val Ser Val Ile Val Pro Asp Tyr Gln Cys Tyr Leu Asp Arg 
        275                 280                 285             


Val Asp Thr Trp Leu Gln Gly Lys Ile Asn Ile Ser Leu Cys Leu Thr 
    290                 295                 300                 


Gly Gly Lys Met Leu Tyr Asn Lys Val Thr Lys Gln Leu Ser Tyr Cys 
305                 310                 315                 320 


Thr Asp Pro Leu Gln Ile Pro Leu Ile Asn Tyr Thr Phe Gly Pro Asn 
                325                 330                 335     


Gln Thr Cys Met Trp Asn Thr Ser Gln Ile Gln Asp Pro Glu Ile Pro 
            340                 345                 350         


Lys Cys Gly Trp Trp Asn Gln Met Ala Tyr Tyr Asn Ser Cys Lys Trp 
        355                 360                 365             


Glu Glu Ala Lys Val Lys Phe His Cys Gln Arg Thr Gln Ser Gln Pro 
    370                 375                 380                 


Gly Ser Trp Phe Arg Ala Ile Ser Ser Trp Lys Gln Arg Asn Arg Trp 
385                 390                 395                 400 


Glu Trp Arg Pro Asp Phe Lys Ser Lys Lys Val Lys Ile Ser Leu Pro 
                405                 410                 415     


Cys Asn Ser Thr Lys Asn Leu Thr Phe Ala Met Arg Ser Ser Gly Asp 
            420                 425                 430         


Tyr Gly Glu Val Thr Gly Ala Trp Ile Glu Phe Gly Cys His Arg Asn 
        435                 440                 445             


Lys Ser Asn Leu His Thr Glu Ala Arg Phe Arg Ile Arg Cys Arg Trp 
    450                 455                 460                 


Asn Val Gly Ser Asp Thr Ser Leu Ile Asp Thr Cys Gly Asn Thr Pro 
465                 470                 475                 480 


Asn Val Ser Gly Ala Asn Pro Val Asp Cys Thr Met Tyr Ser Asn Lys 
                485                 490                 495     


Met Tyr Asn Cys Ser Leu Gln Asn Gly Phe Thr Met Lys Val Asp Asp 
            500                 505                 510         


Leu Ile Val His Phe Asn Met Thr Lys Ala Val Glu Met Tyr Asn Ile 
        515                 520                 525             


Ala Gly Asn Trp Ser Cys Thr Ser Asp Leu Pro Ser Ser Trp Gly Tyr 
    530                 535                 540                 


Met Asn Cys Asn Cys Thr Asn Ser Ser Ser Ser Tyr Ser Gly Thr Lys 
545                 550                 555                 560 


Met Ala Cys Pro Ser Asn Arg Gly Ile Leu Arg Asn Trp Tyr Asn Pro 
                565                 570                 575     


Val Ala Gly Leu Arg Gln Ser Leu Glu Gln Tyr Gln Val Val Lys Gln 
            580                 585                 590         


Pro Asp Tyr Leu Leu Val Pro Glu Glu Val Met Glu Tyr Lys Pro Arg 
        595                 600                 605             


Arg Lys Arg Ala Ala Ile His Val Met Leu Ala Leu Ala Thr Val Leu 
    610                 615                 620                 


Ser Ile Ala Gly Ala Gly Thr Gly Ala Thr Ala Ile Gly Met Val Thr 
625                 630                 635                 640 


Gln Tyr His Gln Val Leu Ala Thr His Gln Glu Ala Ile Glu Lys Val 
                645                 650                 655     


Thr Gly Ala Leu Lys Ile Asn Asn Leu Arg Leu Val Thr Leu Glu His 
            660                 665                 670         


Gln Val Leu Val Ile Gly Leu Lys Val Glu Ala Met Glu Lys Gly Leu 
        675                 680                 685             


Tyr Thr Ala Phe Ala Met Gln Glu Leu Gly Cys Asn Gln Asn Gln Phe 
    690                 695                 700                 


Phe Cys Lys Ile Pro Leu Glu Leu Trp Thr Arg Tyr Asn Met Thr Ile 
705                 710                 715                 720 


Asn Gln Thr Ile Trp Asn His Gly Asn Ile Thr Leu Gly Glu Trp Tyr 
                725                 730                 735     


Asn Gln Thr Lys Asp Leu Gln Gln Lys Phe Tyr Glu Ile Ile Met Asp 
            740                 745                 750         


Ile Glu Gln Asn Asn Val Gln Gly Lys Thr Gly Ile Gln Gln Leu Gln 
        755                 760                 765             


Lys Trp Glu Asp Trp Val Arg Trp Ile Gly Asn Ile Pro Gln Tyr Leu 
    770                 775                 780                 


Lys Gly Leu Leu Gly Gly Ile Leu Gly Ile Gly Leu Gly Val Leu Leu 
785                 790                 795                 800 


Leu Ile Leu Cys Leu Pro Thr Leu Val Asp Cys Ile Arg Asn Cys Ile 
                805                 810                 815     


His Lys Ile Leu Gly Tyr Thr Val Ile Ala Met Pro Glu Val Glu Gly 
            820                 825                 830         


Glu Glu Ile Gln Pro Gln Met Glu Leu Arg Arg Asn Gly Arg Gln Cys 
        835                 840                 845             


Gly Met Ser Glu Lys Glu Glu Glu 
    850                 855     


<210>  318
<211>  856
<212>  PRT
<213>  Artificial sequence

<220>
<223>  Mutated sequence

<400>  318

Met Ala Glu Gly Phe Ala Ala Asn Arg Gln Trp Ile Gly Pro Glu Glu 
1               5                   10                  15      


Ala Glu Glu Leu Leu Asp Phe Asp Ile Ala Thr Gln Met Ser Glu Glu 
            20                  25                  30          


Gly Pro Leu Asn Pro Gly Val Asn Pro Phe Arg Val Pro Gly Ile Thr 
        35                  40                  45              


Glu Lys Glu Lys Gln Asn Tyr Cys Asn Ile Leu Gln Pro Lys Leu Gln 
    50                  55                  60                  


Asp Leu Arg Asn Glu Ile Gln Glu Val Lys Leu Glu Glu Gly Asn Ala 
65                  70                  75                  80  


Gly Lys Phe Arg Arg Ala Arg Phe Leu Arg Tyr Ser Asp Glu Arg Val 
                85                  90                  95      


Leu Ser Leu Val His Ala Phe Ile Gly Tyr Cys Ile Tyr Leu Gly Asn 
            100                 105                 110         


Arg Asn Lys Leu Gly Ser Leu Arg His Asp Ile Asp Ile Glu Ala Pro 
        115                 120                 125             


Gln Glu Glu Cys Tyr Asn Asn Arg Glu Lys Gly Thr Thr Asp Asn Ile 
    130                 135                 140                 


Lys Tyr Gly Arg Arg Cys Cys Leu Gly Thr Val Thr Leu Tyr Leu Ile 
145                 150                 155                 160 


Leu Phe Thr Gly Val Ile Val Tyr Ser Gln Thr Ala Gly Ala Gln Val 
                165                 170                 175     


Val Trp Arg Leu Pro Pro Leu Val Val Pro Val Glu Glu Ser Glu Ile 
            180                 185                 190         


Ile Phe Trp Asp Cys Trp Ala Pro Glu Glu Pro Ala Cys Gln Asp Phe 
        195                 200                 205             


Leu Gly Ala Met Ile His Leu Lys Ala Lys Thr Asn Ile Ser Ile Arg 
    210                 215                 220                 


Glu Gly Pro Thr Leu Gly Asn Trp Ala Arg Glu Ile Trp Ala Thr Leu 
225                 230                 235                 240 


Phe Lys Lys Ala Thr Arg Gln Cys Arg Arg Gly Arg Ile Trp Lys Arg 
                245                 250                 255     


Trp Asn Glu Thr Ile Thr Gly Pro Ser Gly Cys Ala Asn Asn Thr Cys 
            260                 265                 270         


Tyr Asn Val Ser Val Ile Val Pro Asp Tyr Gln Cys Tyr Leu Asp Arg 
        275                 280                 285             


Val Asp Thr Trp Leu Gln Gly Lys Ile Asn Ile Ser Leu Cys Leu Thr 
    290                 295                 300                 


Gly Gly Lys Met Leu Tyr Asn Lys Val Thr Lys Gln Leu Ser Tyr Cys 
305                 310                 315                 320 


Thr Asp Pro Leu Gln Ile Pro Leu Ile Asn Tyr Thr Phe Gly Pro Asn 
                325                 330                 335     


Gln Thr Cys Met Trp Asn Thr Ser Gln Ile Gln Asp Pro Glu Ile Pro 
            340                 345                 350         


Lys Cys Gly Trp Trp Asn Gln Met Ala Tyr Tyr Asn Ser Cys Lys Trp 
        355                 360                 365             


Glu Glu Ala Lys Val Lys Phe His Cys Gln Arg Thr Gln Ser Gln Pro 
    370                 375                 380                 


Gly Ser Trp Phe Arg Ala Ile Ser Ser Trp Lys Gln Arg Asn Arg Trp 
385                 390                 395                 400 


Glu Trp Arg Pro Asp Phe Lys Ser Lys Lys Val Lys Ile Ser Leu Pro 
                405                 410                 415     


Cys Asn Ser Thr Lys Asn Leu Thr Phe Ala Met Arg Ser Ser Gly Asp 
            420                 425                 430         


Tyr Gly Glu Val Thr Gly Ala Trp Ile Glu Phe Gly Cys His Arg Asn 
        435                 440                 445             


Lys Ser Asn Leu His Thr Glu Ala Arg Phe Arg Ile Arg Cys Arg Trp 
    450                 455                 460                 


Asn Val Gly Ser Asp Thr Ser Leu Ile Asp Thr Cys Gly Asn Thr Pro 
465                 470                 475                 480 


Asn Val Ser Gly Ala Asn Pro Val Asp Cys Thr Met Tyr Ser Asn Lys 
                485                 490                 495     


Met Tyr Asn Cys Ser Leu Gln Asn Gly Phe Thr Met Lys Val Asp Asp 
            500                 505                 510         


Leu Ile Val His Phe Asn Met Thr Lys Ala Val Glu Met Tyr Asn Ile 
        515                 520                 525             


Ala Gly Asn Trp Ser Cys Thr Ser Asp Leu Pro Ser Ser Trp Gly Tyr 
    530                 535                 540                 


Met Asn Cys Asn Cys Thr Asn Ser Ser Ser Ser Tyr Ser Gly Thr Lys 
545                 550                 555                 560 


Met Ala Cys Pro Ser Asn Arg Gly Ile Leu Arg Asn Trp Tyr Asn Pro 
                565                 570                 575     


Val Ala Gly Leu Arg Gln Ser Leu Glu Gln Tyr Gln Val Val Lys Gln 
            580                 585                 590         


Pro Asp Tyr Leu Leu Val Pro Glu Glu Val Met Glu Tyr Lys Pro Arg 
        595                 600                 605             


Arg Lys Arg Ala Ala Ile His Val Met Leu Ala Leu Ala Thr Val Leu 
    610                 615                 620                 


Ser Ile Ala Gly Ala Gly Thr Gly Ala Thr Ala Ile Gly Met Val Thr 
625                 630                 635                 640 


Gln Tyr His Gln Val Leu Ala Thr His Gln Glu Ala Ile Glu Lys Val 
                645                 650                 655     


Thr Gly Ala Leu Lys Ile Asn Asn Leu Arg Leu Val Thr Leu Glu His 
            660                 665                 670         


Gln Val Leu Val Ile Gly Leu Lys Val Glu Ala Met Glu Lys Leu Leu 
        675                 680                 685             


Tyr Thr Ala Phe Ala Met Gln Glu Leu Gly Cys Asn Gln Asn Gln Phe 
    690                 695                 700                 


Phe Cys Lys Ile Pro Leu Glu Leu Trp Thr Arg Tyr Asn Met Thr Ile 
705                 710                 715                 720 


Asn Gln Thr Ile Trp Asn His Gly Asn Ile Thr Leu Gly Glu Trp Tyr 
                725                 730                 735     


Asn Gln Thr Lys Asp Leu Gln Gln Lys Phe Tyr Glu Ile Ile Met Asp 
            740                 745                 750         


Ile Glu Gln Asn Asn Val Gln Gly Lys Thr Gly Ile Gln Gln Leu Gln 
        755                 760                 765             


Lys Trp Glu Asp Trp Val Arg Trp Ile Gly Asn Ile Pro Gln Tyr Leu 
    770                 775                 780                 


Lys Gly Leu Leu Gly Gly Ile Leu Gly Ile Gly Leu Gly Val Leu Leu 
785                 790                 795                 800 


Leu Ile Leu Cys Leu Pro Thr Leu Val Asp Cys Ile Arg Asn Cys Ile 
                805                 810                 815     


His Lys Ile Leu Gly Tyr Thr Val Ile Ala Met Pro Glu Val Glu Gly 
            820                 825                 830         


Glu Glu Ile Gln Pro Gln Met Glu Leu Arg Arg Asn Gly Arg Gln Cys 
        835                 840                 845             


Gly Met Ser Glu Lys Glu Glu Glu 
    850                 855     


<210>  319
<211>  856
<212>  PRT
<213>  Artificial sequence

<220>
<223>  Mutated sequence

<400>  319

Met Ala Glu Gly Phe Ala Ala Asn Arg Gln Trp Ile Gly Pro Glu Glu 
1               5                   10                  15      


Ala Glu Glu Leu Leu Asp Phe Asp Ile Ala Thr Gln Met Ser Glu Glu 
            20                  25                  30          


Gly Pro Leu Asn Pro Gly Val Asn Pro Phe Arg Val Pro Gly Ile Thr 
        35                  40                  45              


Glu Lys Glu Lys Gln Asn Tyr Cys Asn Ile Leu Gln Pro Lys Leu Gln 
    50                  55                  60                  


Asp Leu Arg Asn Glu Ile Gln Glu Val Lys Leu Glu Glu Gly Asn Ala 
65                  70                  75                  80  


Gly Lys Phe Arg Arg Ala Arg Phe Leu Arg Tyr Ser Asp Glu Arg Val 
                85                  90                  95      


Leu Ser Leu Val His Ala Phe Ile Gly Tyr Cys Ile Tyr Leu Gly Asn 
            100                 105                 110         


Arg Asn Lys Leu Gly Ser Leu Arg His Asp Ile Asp Ile Glu Ala Pro 
        115                 120                 125             


Gln Glu Glu Cys Tyr Asn Asn Arg Glu Lys Gly Thr Thr Asp Asn Ile 
    130                 135                 140                 


Lys Tyr Gly Arg Arg Cys Cys Leu Gly Thr Val Thr Leu Tyr Leu Ile 
145                 150                 155                 160 


Leu Phe Thr Gly Val Ile Val Tyr Ser Gln Thr Ala Gly Ala Gln Val 
                165                 170                 175     


Val Trp Arg Leu Pro Pro Leu Val Val Pro Val Glu Glu Ser Glu Ile 
            180                 185                 190         


Ile Phe Trp Asp Cys Trp Ala Pro Glu Glu Pro Ala Cys Gln Asp Phe 
        195                 200                 205             


Leu Gly Ala Met Ile His Leu Lys Ala Lys Thr Asn Ile Ser Ile Arg 
    210                 215                 220                 


Glu Gly Pro Thr Leu Gly Asn Trp Ala Arg Glu Ile Trp Ala Thr Leu 
225                 230                 235                 240 


Phe Lys Lys Ala Thr Arg Gln Cys Arg Arg Gly Arg Ile Trp Lys Arg 
                245                 250                 255     


Trp Asn Glu Thr Ile Thr Gly Pro Ser Gly Cys Ala Asn Asn Thr Cys 
            260                 265                 270         


Tyr Asn Val Ser Val Ile Val Pro Asp Tyr Gln Cys Tyr Leu Asp Arg 
        275                 280                 285             


Val Asp Thr Trp Leu Gln Gly Lys Ile Asn Ile Ser Leu Cys Leu Thr 
    290                 295                 300                 


Gly Gly Lys Met Leu Tyr Asn Lys Val Thr Lys Gln Leu Ser Tyr Cys 
305                 310                 315                 320 


Thr Asp Pro Leu Gln Ile Pro Leu Ile Asn Tyr Thr Phe Gly Pro Asn 
                325                 330                 335     


Gln Thr Cys Met Trp Asn Thr Ser Gln Ile Gln Asp Pro Glu Ile Pro 
            340                 345                 350         


Lys Cys Gly Trp Trp Asn Gln Met Ala Tyr Tyr Asn Ser Cys Lys Trp 
        355                 360                 365             


Glu Glu Ala Lys Val Lys Phe His Cys Gln Arg Thr Gln Ser Gln Pro 
    370                 375                 380                 


Gly Ser Trp Phe Arg Ala Ile Ser Ser Trp Lys Gln Arg Asn Arg Trp 
385                 390                 395                 400 


Glu Trp Arg Pro Asp Phe Lys Ser Lys Lys Val Lys Ile Ser Leu Pro 
                405                 410                 415     


Cys Asn Ser Thr Lys Asn Leu Thr Phe Ala Met Arg Ser Ser Gly Asp 
            420                 425                 430         


Tyr Gly Glu Val Thr Gly Ala Trp Ile Glu Phe Gly Cys His Arg Asn 
        435                 440                 445             


Lys Ser Asn Leu His Thr Glu Ala Arg Phe Arg Ile Arg Cys Arg Trp 
    450                 455                 460                 


Asn Val Gly Ser Asp Thr Ser Leu Ile Asp Thr Cys Gly Asn Thr Pro 
465                 470                 475                 480 


Asn Val Ser Gly Ala Asn Pro Val Asp Cys Thr Met Tyr Ser Asn Lys 
                485                 490                 495     


Met Tyr Asn Cys Ser Leu Gln Asn Gly Phe Thr Met Lys Val Asp Asp 
            500                 505                 510         


Leu Ile Val His Phe Asn Met Thr Lys Ala Val Glu Met Tyr Asn Ile 
        515                 520                 525             


Ala Gly Asn Trp Ser Cys Thr Ser Asp Leu Pro Ser Ser Trp Gly Tyr 
    530                 535                 540                 


Met Asn Cys Asn Cys Thr Asn Ser Ser Ser Ser Tyr Ser Gly Thr Lys 
545                 550                 555                 560 


Met Ala Cys Pro Ser Asn Arg Gly Ile Leu Arg Asn Trp Tyr Asn Pro 
                565                 570                 575     


Val Ala Gly Leu Arg Gln Ser Leu Glu Gln Tyr Gln Val Val Lys Gln 
            580                 585                 590         


Pro Asp Tyr Leu Leu Val Pro Glu Glu Val Met Glu Tyr Lys Pro Arg 
        595                 600                 605             


Arg Lys Arg Ala Ala Ile His Val Met Leu Ala Leu Ala Thr Val Leu 
    610                 615                 620                 


Ser Ile Ala Gly Ala Gly Thr Gly Ala Thr Ala Ile Gly Met Val Thr 
625                 630                 635                 640 


Gln Tyr His Gln Val Leu Ala Thr His Gln Glu Ala Ile Glu Lys Val 
                645                 650                 655     


Thr Gly Ala Leu Lys Ile Asn Asn Leu Arg Leu Val Thr Leu Glu His 
            660                 665                 670         


Gln Val Leu Val Ile Gly Leu Lys Val Glu Ala Met Glu Lys Ala Leu 
        675                 680                 685             


Tyr Thr Ala Phe Ala Met Gln Glu Leu Gly Cys Asn Gln Asn Gln Phe 
    690                 695                 700                 


Phe Cys Lys Ile Pro Leu Glu Leu Trp Thr Arg Tyr Asn Met Thr Ile 
705                 710                 715                 720 


Asn Gln Thr Ile Trp Asn His Gly Asn Ile Thr Leu Gly Glu Trp Tyr 
                725                 730                 735     


Asn Gln Thr Lys Asp Leu Gln Gln Lys Phe Tyr Glu Ile Ile Met Asp 
            740                 745                 750         


Ile Glu Gln Asn Asn Val Gln Gly Lys Thr Gly Ile Gln Gln Leu Gln 
        755                 760                 765             


Lys Trp Glu Asp Trp Val Arg Trp Ile Gly Asn Ile Pro Gln Tyr Leu 
    770                 775                 780                 


Lys Gly Leu Leu Gly Gly Ile Leu Gly Ile Gly Leu Gly Val Leu Leu 
785                 790                 795                 800 


Leu Ile Leu Cys Leu Pro Thr Leu Val Asp Cys Ile Arg Asn Cys Ile 
                805                 810                 815     


His Lys Ile Leu Gly Tyr Thr Val Ile Ala Met Pro Glu Val Glu Gly 
            820                 825                 830         


Glu Glu Ile Gln Pro Gln Met Glu Leu Arg Arg Asn Gly Arg Gln Cys 
        835                 840                 845             


Gly Met Ser Glu Lys Glu Glu Glu 
    850                 855     


<210>  320
<211>  856
<212>  PRT
<213>  Artificial sequence

<220>
<223>  Mutated sequence

<400>  320

Met Ala Glu Gly Phe Ala Ala Asn Arg Gln Trp Ile Gly Pro Glu Glu 
1               5                   10                  15      


Ala Glu Glu Leu Leu Asp Phe Asp Ile Ala Thr Gln Met Ser Glu Glu 
            20                  25                  30          


Gly Pro Leu Asn Pro Gly Val Asn Pro Phe Arg Val Pro Gly Ile Thr 
        35                  40                  45              


Glu Lys Glu Lys Gln Asn Tyr Cys Asn Ile Leu Gln Pro Lys Leu Gln 
    50                  55                  60                  


Asp Leu Arg Asn Glu Ile Gln Glu Val Lys Leu Glu Glu Gly Asn Ala 
65                  70                  75                  80  


Gly Lys Phe Arg Arg Ala Arg Phe Leu Arg Tyr Ser Asp Glu Arg Val 
                85                  90                  95      


Leu Ser Leu Val His Ala Phe Ile Gly Tyr Cys Ile Tyr Leu Gly Asn 
            100                 105                 110         


Arg Asn Lys Leu Gly Ser Leu Arg His Asp Ile Asp Ile Glu Ala Pro 
        115                 120                 125             


Gln Glu Glu Cys Tyr Asn Asn Arg Glu Lys Gly Thr Thr Asp Asn Ile 
    130                 135                 140                 


Lys Tyr Gly Arg Arg Cys Cys Leu Gly Thr Val Thr Leu Tyr Leu Ile 
145                 150                 155                 160 


Leu Phe Thr Gly Val Ile Val Tyr Ser Gln Thr Ala Gly Ala Gln Val 
                165                 170                 175     


Val Trp Arg Leu Pro Pro Leu Val Val Pro Val Glu Glu Ser Glu Ile 
            180                 185                 190         


Ile Phe Trp Asp Cys Trp Ala Pro Glu Glu Pro Ala Cys Gln Asp Phe 
        195                 200                 205             


Leu Gly Ala Met Ile His Leu Lys Ala Lys Thr Asn Ile Ser Ile Arg 
    210                 215                 220                 


Glu Gly Pro Thr Leu Gly Asn Trp Ala Arg Glu Ile Trp Ala Thr Leu 
225                 230                 235                 240 


Phe Lys Lys Ala Thr Arg Gln Cys Arg Arg Gly Arg Ile Trp Lys Arg 
                245                 250                 255     


Trp Asn Glu Thr Ile Thr Gly Pro Ser Gly Cys Ala Asn Asn Thr Cys 
            260                 265                 270         


Tyr Asn Val Ser Val Ile Val Pro Asp Tyr Gln Cys Tyr Leu Asp Arg 
        275                 280                 285             


Val Asp Thr Trp Leu Gln Gly Lys Ile Asn Ile Ser Leu Cys Leu Thr 
    290                 295                 300                 


Gly Gly Lys Met Leu Tyr Asn Lys Val Thr Lys Gln Leu Ser Tyr Cys 
305                 310                 315                 320 


Thr Asp Pro Leu Gln Ile Pro Leu Ile Asn Tyr Thr Phe Gly Pro Asn 
                325                 330                 335     


Gln Thr Cys Met Trp Asn Thr Ser Gln Ile Gln Asp Pro Glu Ile Pro 
            340                 345                 350         


Lys Cys Gly Trp Trp Asn Gln Met Ala Tyr Tyr Asn Ser Cys Lys Trp 
        355                 360                 365             


Glu Glu Ala Lys Val Lys Phe His Cys Gln Arg Thr Gln Ser Gln Pro 
    370                 375                 380                 


Gly Ser Trp Phe Arg Ala Ile Ser Ser Trp Lys Gln Arg Asn Arg Trp 
385                 390                 395                 400 


Glu Trp Arg Pro Asp Phe Lys Ser Lys Lys Val Lys Ile Ser Leu Pro 
                405                 410                 415     


Cys Asn Ser Thr Lys Asn Leu Thr Phe Ala Met Arg Ser Ser Gly Asp 
            420                 425                 430         


Tyr Gly Glu Val Thr Gly Ala Trp Ile Glu Phe Gly Cys His Arg Asn 
        435                 440                 445             


Lys Ser Asn Leu His Thr Glu Ala Arg Phe Arg Ile Arg Cys Arg Trp 
    450                 455                 460                 


Asn Val Gly Ser Asp Thr Ser Leu Ile Asp Thr Cys Gly Asn Thr Pro 
465                 470                 475                 480 


Asn Val Ser Gly Ala Asn Pro Val Asp Cys Thr Met Tyr Ser Asn Lys 
                485                 490                 495     


Met Tyr Asn Cys Ser Leu Gln Asn Gly Phe Thr Met Lys Val Asp Asp 
            500                 505                 510         


Leu Ile Val His Phe Asn Met Thr Lys Ala Val Glu Met Tyr Asn Ile 
        515                 520                 525             


Ala Gly Asn Trp Ser Cys Thr Ser Asp Leu Pro Ser Ser Trp Gly Tyr 
    530                 535                 540                 


Met Asn Cys Asn Cys Thr Asn Ser Ser Ser Ser Tyr Ser Gly Thr Lys 
545                 550                 555                 560 


Met Ala Cys Pro Ser Asn Arg Gly Ile Leu Arg Asn Trp Tyr Asn Pro 
                565                 570                 575     


Val Ala Gly Leu Arg Gln Ser Leu Glu Gln Tyr Gln Val Val Lys Gln 
            580                 585                 590         


Pro Asp Tyr Leu Leu Val Pro Glu Glu Val Met Glu Tyr Lys Pro Arg 
        595                 600                 605             


Arg Lys Arg Ala Ala Ile His Val Met Leu Ala Leu Ala Thr Val Leu 
    610                 615                 620                 


Ser Ile Ala Gly Ala Gly Thr Gly Ala Thr Ala Ile Gly Met Val Thr 
625                 630                 635                 640 


Gln Tyr His Gln Val Leu Ala Thr His Gln Glu Ala Ile Glu Lys Val 
                645                 650                 655     


Thr Gly Ala Leu Lys Ile Asn Asn Leu Arg Leu Val Thr Leu Glu His 
            660                 665                 670         


Gln Val Leu Val Ile Gly Leu Lys Val Glu Ala Met Glu Lys Phe Arg 
        675                 680                 685             


Tyr Thr Ala Phe Ala Met Gln Glu Leu Gly Cys Asn Gln Asn Gln Phe 
    690                 695                 700                 


Phe Cys Lys Ile Pro Leu Glu Leu Trp Thr Arg Tyr Asn Met Thr Ile 
705                 710                 715                 720 


Asn Gln Thr Ile Trp Asn His Gly Asn Ile Thr Leu Gly Glu Trp Tyr 
                725                 730                 735     


Asn Gln Thr Lys Asp Leu Gln Gln Lys Phe Tyr Glu Ile Ile Met Asp 
            740                 745                 750         


Ile Glu Gln Asn Asn Val Gln Gly Lys Thr Gly Ile Gln Gln Leu Gln 
        755                 760                 765             


Lys Trp Glu Asp Trp Val Arg Trp Ile Gly Asn Ile Pro Gln Tyr Leu 
    770                 775                 780                 


Lys Gly Leu Leu Gly Gly Ile Leu Gly Ile Gly Leu Gly Val Leu Leu 
785                 790                 795                 800 


Leu Ile Leu Cys Leu Pro Thr Leu Val Asp Cys Ile Arg Asn Cys Ile 
                805                 810                 815     


His Lys Ile Leu Gly Tyr Thr Val Ile Ala Met Pro Glu Val Glu Gly 
            820                 825                 830         


Glu Glu Ile Gln Pro Gln Met Glu Leu Arg Arg Asn Gly Arg Gln Cys 
        835                 840                 845             


Gly Met Ser Glu Lys Glu Glu Glu 
    850                 855     


<210>  321
<211>  856
<212>  PRT
<213>  Artificial sequence

<220>
<223>  Mutated sequence

<400>  321

Met Ala Glu Gly Phe Ala Ala Asn Arg Gln Trp Ile Gly Pro Glu Glu 
1               5                   10                  15      


Ala Glu Glu Leu Leu Asp Phe Asp Ile Ala Thr Gln Met Ser Glu Glu 
            20                  25                  30          


Gly Pro Leu Asn Pro Gly Val Asn Pro Phe Arg Val Pro Gly Ile Thr 
        35                  40                  45              


Glu Lys Glu Lys Gln Asn Tyr Cys Asn Ile Leu Gln Pro Lys Leu Gln 
    50                  55                  60                  


Asp Leu Arg Asn Glu Ile Gln Glu Val Lys Leu Glu Glu Gly Asn Ala 
65                  70                  75                  80  


Gly Lys Phe Arg Arg Ala Arg Phe Leu Arg Tyr Ser Asp Glu Arg Val 
                85                  90                  95      


Leu Ser Leu Val His Ala Phe Ile Gly Tyr Cys Ile Tyr Leu Gly Asn 
            100                 105                 110         


Arg Asn Lys Leu Gly Ser Leu Arg His Asp Ile Asp Ile Glu Ala Pro 
        115                 120                 125             


Gln Glu Glu Cys Tyr Asn Asn Arg Glu Lys Gly Thr Thr Asp Asn Ile 
    130                 135                 140                 


Lys Tyr Gly Arg Arg Cys Cys Leu Gly Thr Val Thr Leu Tyr Leu Ile 
145                 150                 155                 160 


Leu Phe Thr Gly Val Ile Val Tyr Ser Gln Thr Ala Gly Ala Gln Val 
                165                 170                 175     


Val Trp Arg Leu Pro Pro Leu Val Val Pro Val Glu Glu Ser Glu Ile 
            180                 185                 190         


Ile Phe Trp Asp Cys Trp Ala Pro Glu Glu Pro Ala Cys Gln Asp Phe 
        195                 200                 205             


Leu Gly Ala Met Ile His Leu Lys Ala Lys Thr Asn Ile Ser Ile Arg 
    210                 215                 220                 


Glu Gly Pro Thr Leu Gly Asn Trp Ala Arg Glu Ile Trp Ala Thr Leu 
225                 230                 235                 240 


Phe Lys Lys Ala Thr Arg Gln Cys Arg Arg Gly Arg Ile Trp Lys Arg 
                245                 250                 255     


Trp Asn Glu Thr Ile Thr Gly Pro Ser Gly Cys Ala Asn Asn Thr Cys 
            260                 265                 270         


Tyr Asn Val Ser Val Ile Val Pro Asp Tyr Gln Cys Tyr Leu Asp Arg 
        275                 280                 285             


Val Asp Thr Trp Leu Gln Gly Lys Ile Asn Ile Ser Leu Cys Leu Thr 
    290                 295                 300                 


Gly Gly Lys Met Leu Tyr Asn Lys Val Thr Lys Gln Leu Ser Tyr Cys 
305                 310                 315                 320 


Thr Asp Pro Leu Gln Ile Pro Leu Ile Asn Tyr Thr Phe Gly Pro Asn 
                325                 330                 335     


Gln Thr Cys Met Trp Asn Thr Ser Gln Ile Gln Asp Pro Glu Ile Pro 
            340                 345                 350         


Lys Cys Gly Trp Trp Asn Gln Met Ala Tyr Tyr Asn Ser Cys Lys Trp 
        355                 360                 365             


Glu Glu Ala Lys Val Lys Phe His Cys Gln Arg Thr Gln Ser Gln Pro 
    370                 375                 380                 


Gly Ser Trp Phe Arg Ala Ile Ser Ser Trp Lys Gln Arg Asn Arg Trp 
385                 390                 395                 400 


Glu Trp Arg Pro Asp Phe Lys Ser Lys Lys Val Lys Ile Ser Leu Pro 
                405                 410                 415     


Cys Asn Ser Thr Lys Asn Leu Thr Phe Ala Met Arg Ser Ser Gly Asp 
            420                 425                 430         


Tyr Gly Glu Val Thr Gly Ala Trp Ile Glu Phe Gly Cys His Arg Asn 
        435                 440                 445             


Lys Ser Asn Leu His Thr Glu Ala Arg Phe Arg Ile Arg Cys Arg Trp 
    450                 455                 460                 


Asn Val Gly Ser Asp Thr Ser Leu Ile Asp Thr Cys Gly Asn Thr Pro 
465                 470                 475                 480 


Asn Val Ser Gly Ala Asn Pro Val Asp Cys Thr Met Tyr Ser Asn Lys 
                485                 490                 495     


Met Tyr Asn Cys Ser Leu Gln Asn Gly Phe Thr Met Lys Val Asp Asp 
            500                 505                 510         


Leu Ile Val His Phe Asn Met Thr Lys Ala Val Glu Met Tyr Asn Ile 
        515                 520                 525             


Ala Gly Asn Trp Ser Cys Thr Ser Asp Leu Pro Ser Ser Trp Gly Tyr 
    530                 535                 540                 


Met Asn Cys Asn Cys Thr Asn Ser Ser Ser Ser Tyr Ser Gly Thr Lys 
545                 550                 555                 560 


Met Ala Cys Pro Ser Asn Arg Gly Ile Leu Arg Asn Trp Tyr Asn Pro 
                565                 570                 575     


Val Ala Gly Leu Arg Gln Ser Leu Glu Gln Tyr Gln Val Val Lys Gln 
            580                 585                 590         


Pro Asp Tyr Leu Leu Val Pro Glu Glu Val Met Glu Tyr Lys Pro Arg 
        595                 600                 605             


Arg Lys Arg Ala Ala Ile His Val Met Leu Ala Leu Ala Thr Val Leu 
    610                 615                 620                 


Ser Ile Ala Gly Ala Gly Thr Gly Ala Thr Ala Ile Gly Met Val Thr 
625                 630                 635                 640 


Gln Tyr His Gln Val Leu Ala Thr His Gln Glu Ala Ile Glu Lys Val 
                645                 650                 655     


Thr Gly Ala Leu Lys Ile Asn Asn Leu Arg Leu Val Thr Leu Glu His 
            660                 665                 670         


Gln Val Leu Val Ile Gly Leu Lys Val Glu Ala Met Glu Lys Phe Gly 
        675                 680                 685             


Tyr Thr Ala Phe Ala Met Gln Glu Leu Gly Cys Asn Gln Asn Gln Phe 
    690                 695                 700                 


Phe Cys Lys Ile Pro Leu Glu Leu Trp Thr Arg Tyr Asn Met Thr Ile 
705                 710                 715                 720 


Asn Gln Thr Ile Trp Asn His Gly Asn Ile Thr Leu Gly Glu Trp Tyr 
                725                 730                 735     


Asn Gln Thr Lys Asp Leu Gln Gln Lys Phe Tyr Glu Ile Ile Met Asp 
            740                 745                 750         


Ile Glu Gln Asn Asn Val Gln Gly Lys Thr Gly Ile Gln Gln Leu Gln 
        755                 760                 765             


Lys Trp Glu Asp Trp Val Arg Trp Ile Gly Asn Ile Pro Gln Tyr Leu 
    770                 775                 780                 


Lys Gly Leu Leu Gly Gly Ile Leu Gly Ile Gly Leu Gly Val Leu Leu 
785                 790                 795                 800 


Leu Ile Leu Cys Leu Pro Thr Leu Val Asp Cys Ile Arg Asn Cys Ile 
                805                 810                 815     


His Lys Ile Leu Gly Tyr Thr Val Ile Ala Met Pro Glu Val Glu Gly 
            820                 825                 830         


Glu Glu Ile Gln Pro Gln Met Glu Leu Arg Arg Asn Gly Arg Gln Cys 
        835                 840                 845             


Gly Met Ser Glu Lys Glu Glu Glu 
    850                 855     


<210>  322
<211>  856
<212>  PRT
<213>  Artificial sequence

<220>
<223>  Mutated sequence

<400>  322

Met Ala Glu Gly Phe Ala Ala Asn Arg Gln Trp Ile Gly Pro Glu Glu 
1               5                   10                  15      


Ala Glu Glu Leu Leu Asp Phe Asp Ile Ala Thr Gln Met Ser Glu Glu 
            20                  25                  30          


Gly Pro Leu Asn Pro Gly Val Asn Pro Phe Arg Val Pro Gly Ile Thr 
        35                  40                  45              


Glu Lys Glu Lys Gln Asn Tyr Cys Asn Ile Leu Gln Pro Lys Leu Gln 
    50                  55                  60                  


Asp Leu Arg Asn Glu Ile Gln Glu Val Lys Leu Glu Glu Gly Asn Ala 
65                  70                  75                  80  


Gly Lys Phe Arg Arg Ala Arg Phe Leu Arg Tyr Ser Asp Glu Arg Val 
                85                  90                  95      


Leu Ser Leu Val His Ala Phe Ile Gly Tyr Cys Ile Tyr Leu Gly Asn 
            100                 105                 110         


Arg Asn Lys Leu Gly Ser Leu Arg His Asp Ile Asp Ile Glu Ala Pro 
        115                 120                 125             


Gln Glu Glu Cys Tyr Asn Asn Arg Glu Lys Gly Thr Thr Asp Asn Ile 
    130                 135                 140                 


Lys Tyr Gly Arg Arg Cys Cys Leu Gly Thr Val Thr Leu Tyr Leu Ile 
145                 150                 155                 160 


Leu Phe Thr Gly Val Ile Val Tyr Ser Gln Thr Ala Gly Ala Gln Val 
                165                 170                 175     


Val Trp Arg Leu Pro Pro Leu Val Val Pro Val Glu Glu Ser Glu Ile 
            180                 185                 190         


Ile Phe Trp Asp Cys Trp Ala Pro Glu Glu Pro Ala Cys Gln Asp Phe 
        195                 200                 205             


Leu Gly Ala Met Ile His Leu Lys Ala Lys Thr Asn Ile Ser Ile Arg 
    210                 215                 220                 


Glu Gly Pro Thr Leu Gly Asn Trp Ala Arg Glu Ile Trp Ala Thr Leu 
225                 230                 235                 240 


Phe Lys Lys Ala Thr Arg Gln Cys Arg Arg Gly Arg Ile Trp Lys Arg 
                245                 250                 255     


Trp Asn Glu Thr Ile Thr Gly Pro Ser Gly Cys Ala Asn Asn Thr Cys 
            260                 265                 270         


Tyr Asn Val Ser Val Ile Val Pro Asp Tyr Gln Cys Tyr Leu Asp Arg 
        275                 280                 285             


Val Asp Thr Trp Leu Gln Gly Lys Ile Asn Ile Ser Leu Cys Leu Thr 
    290                 295                 300                 


Gly Gly Lys Met Leu Tyr Asn Lys Val Thr Lys Gln Leu Ser Tyr Cys 
305                 310                 315                 320 


Thr Asp Pro Leu Gln Ile Pro Leu Ile Asn Tyr Thr Phe Gly Pro Asn 
                325                 330                 335     


Gln Thr Cys Met Trp Asn Thr Ser Gln Ile Gln Asp Pro Glu Ile Pro 
            340                 345                 350         


Lys Cys Gly Trp Trp Asn Gln Met Ala Tyr Tyr Asn Ser Cys Lys Trp 
        355                 360                 365             


Glu Glu Ala Lys Val Lys Phe His Cys Gln Arg Thr Gln Ser Gln Pro 
    370                 375                 380                 


Gly Ser Trp Phe Arg Ala Ile Ser Ser Trp Lys Gln Arg Asn Arg Trp 
385                 390                 395                 400 


Glu Trp Arg Pro Asp Phe Lys Ser Lys Lys Val Lys Ile Ser Leu Pro 
                405                 410                 415     


Cys Asn Ser Thr Lys Asn Leu Thr Phe Ala Met Arg Ser Ser Gly Asp 
            420                 425                 430         


Tyr Gly Glu Val Thr Gly Ala Trp Ile Glu Phe Gly Cys His Arg Asn 
        435                 440                 445             


Lys Ser Asn Leu His Thr Glu Ala Arg Phe Arg Ile Arg Cys Arg Trp 
    450                 455                 460                 


Asn Val Gly Ser Asp Thr Ser Leu Ile Asp Thr Cys Gly Asn Thr Pro 
465                 470                 475                 480 


Asn Val Ser Gly Ala Asn Pro Val Asp Cys Thr Met Tyr Ser Asn Lys 
                485                 490                 495     


Met Tyr Asn Cys Ser Leu Gln Asn Gly Phe Thr Met Lys Val Asp Asp 
            500                 505                 510         


Leu Ile Val His Phe Asn Met Thr Lys Ala Val Glu Met Tyr Asn Ile 
        515                 520                 525             


Ala Gly Asn Trp Ser Cys Thr Ser Asp Leu Pro Ser Ser Trp Gly Tyr 
    530                 535                 540                 


Met Asn Cys Asn Cys Thr Asn Ser Ser Ser Ser Tyr Ser Gly Thr Lys 
545                 550                 555                 560 


Met Ala Cys Pro Ser Asn Arg Gly Ile Leu Arg Asn Trp Tyr Asn Pro 
                565                 570                 575     


Val Ala Gly Leu Arg Gln Ser Leu Glu Gln Tyr Gln Val Val Lys Gln 
            580                 585                 590         


Pro Asp Tyr Leu Leu Val Pro Glu Glu Val Met Glu Tyr Lys Pro Arg 
        595                 600                 605             


Arg Lys Arg Ala Ala Ile His Val Met Leu Ala Leu Ala Thr Val Leu 
    610                 615                 620                 


Ser Ile Ala Gly Ala Gly Thr Gly Ala Thr Ala Ile Gly Met Val Thr 
625                 630                 635                 640 


Gln Tyr His Gln Val Leu Ala Thr His Gln Glu Ala Ile Glu Lys Val 
                645                 650                 655     


Thr Gly Ala Leu Lys Ile Asn Asn Leu Arg Leu Val Thr Leu Glu His 
            660                 665                 670         


Gln Val Leu Val Ile Gly Leu Lys Val Glu Ala Met Glu Lys Phe Ala 
        675                 680                 685             


Tyr Thr Ala Phe Ala Met Gln Glu Leu Gly Cys Asn Gln Asn Gln Phe 
    690                 695                 700                 


Phe Cys Lys Ile Pro Leu Glu Leu Trp Thr Arg Tyr Asn Met Thr Ile 
705                 710                 715                 720 


Asn Gln Thr Ile Trp Asn His Gly Asn Ile Thr Leu Gly Glu Trp Tyr 
                725                 730                 735     


Asn Gln Thr Lys Asp Leu Gln Gln Lys Phe Tyr Glu Ile Ile Met Asp 
            740                 745                 750         


Ile Glu Gln Asn Asn Val Gln Gly Lys Thr Gly Ile Gln Gln Leu Gln 
        755                 760                 765             


Lys Trp Glu Asp Trp Val Arg Trp Ile Gly Asn Ile Pro Gln Tyr Leu 
    770                 775                 780                 


Lys Gly Leu Leu Gly Gly Ile Leu Gly Ile Gly Leu Gly Val Leu Leu 
785                 790                 795                 800 


Leu Ile Leu Cys Leu Pro Thr Leu Val Asp Cys Ile Arg Asn Cys Ile 
                805                 810                 815     


His Lys Ile Leu Gly Tyr Thr Val Ile Ala Met Pro Glu Val Glu Gly 
            820                 825                 830         


Glu Glu Ile Gln Pro Gln Met Glu Leu Arg Arg Asn Gly Arg Gln Cys 
        835                 840                 845             


Gly Met Ser Glu Lys Glu Glu Glu 
    850                 855     


<210>  323
<211>  856
<212>  PRT
<213>  Artificial sequence

<220>
<223>  Mutated sequence

<400>  323

Met Ala Glu Gly Phe Ala Ala Asn Arg Gln Trp Ile Gly Pro Glu Glu 
1               5                   10                  15      


Ala Glu Glu Leu Leu Asp Phe Asp Ile Ala Thr Gln Met Ser Glu Glu 
            20                  25                  30          


Gly Pro Leu Asn Pro Gly Val Asn Pro Phe Arg Val Pro Gly Ile Thr 
        35                  40                  45              


Glu Lys Glu Lys Gln Asn Tyr Cys Asn Ile Leu Gln Pro Lys Leu Gln 
    50                  55                  60                  


Asp Leu Arg Asn Glu Ile Gln Glu Val Lys Leu Glu Glu Gly Asn Ala 
65                  70                  75                  80  


Gly Lys Phe Arg Arg Ala Arg Phe Leu Arg Tyr Ser Asp Glu Arg Val 
                85                  90                  95      


Leu Ser Leu Val His Ala Phe Ile Gly Tyr Cys Ile Tyr Leu Gly Asn 
            100                 105                 110         


Arg Asn Lys Leu Gly Ser Leu Arg His Asp Ile Asp Ile Glu Ala Pro 
        115                 120                 125             


Gln Glu Glu Cys Tyr Asn Asn Arg Glu Lys Gly Thr Thr Asp Asn Ile 
    130                 135                 140                 


Lys Tyr Gly Arg Arg Cys Cys Leu Gly Thr Val Thr Leu Tyr Leu Ile 
145                 150                 155                 160 


Leu Phe Thr Gly Val Ile Val Tyr Ser Gln Thr Ala Gly Ala Gln Val 
                165                 170                 175     


Val Trp Arg Leu Pro Pro Leu Val Val Pro Val Glu Glu Ser Glu Ile 
            180                 185                 190         


Ile Phe Trp Asp Cys Trp Ala Pro Glu Glu Pro Ala Cys Gln Asp Phe 
        195                 200                 205             


Leu Gly Ala Met Ile His Leu Lys Ala Lys Thr Asn Ile Ser Ile Arg 
    210                 215                 220                 


Glu Gly Pro Thr Leu Gly Asn Trp Ala Arg Glu Ile Trp Ala Thr Leu 
225                 230                 235                 240 


Phe Lys Lys Ala Thr Arg Gln Cys Arg Arg Gly Arg Ile Trp Lys Arg 
                245                 250                 255     


Trp Asn Glu Thr Ile Thr Gly Pro Ser Gly Cys Ala Asn Asn Thr Cys 
            260                 265                 270         


Tyr Asn Val Ser Val Ile Val Pro Asp Tyr Gln Cys Tyr Leu Asp Arg 
        275                 280                 285             


Val Asp Thr Trp Leu Gln Gly Lys Ile Asn Ile Ser Leu Cys Leu Thr 
    290                 295                 300                 


Gly Gly Lys Met Leu Tyr Asn Lys Val Thr Lys Gln Leu Ser Tyr Cys 
305                 310                 315                 320 


Thr Asp Pro Leu Gln Ile Pro Leu Ile Asn Tyr Thr Phe Gly Pro Asn 
                325                 330                 335     


Gln Thr Cys Met Trp Asn Thr Ser Gln Ile Gln Asp Pro Glu Ile Pro 
            340                 345                 350         


Lys Cys Gly Trp Trp Asn Gln Met Ala Tyr Tyr Asn Ser Cys Lys Trp 
        355                 360                 365             


Glu Glu Ala Lys Val Lys Phe His Cys Gln Arg Thr Gln Ser Gln Pro 
    370                 375                 380                 


Gly Ser Trp Phe Arg Ala Ile Ser Ser Trp Lys Gln Arg Asn Arg Trp 
385                 390                 395                 400 


Glu Trp Arg Pro Asp Phe Lys Ser Lys Lys Val Lys Ile Ser Leu Pro 
                405                 410                 415     


Cys Asn Ser Thr Lys Asn Leu Thr Phe Ala Met Arg Ser Ser Gly Asp 
            420                 425                 430         


Tyr Gly Glu Val Thr Gly Ala Trp Ile Glu Phe Gly Cys His Arg Asn 
        435                 440                 445             


Lys Ser Asn Leu His Thr Glu Ala Arg Phe Arg Ile Arg Cys Arg Trp 
    450                 455                 460                 


Asn Val Gly Ser Asp Thr Ser Leu Ile Asp Thr Cys Gly Asn Thr Pro 
465                 470                 475                 480 


Asn Val Ser Gly Ala Asn Pro Val Asp Cys Thr Met Tyr Ser Asn Lys 
                485                 490                 495     


Met Tyr Asn Cys Ser Leu Gln Asn Gly Phe Thr Met Lys Val Asp Asp 
            500                 505                 510         


Leu Ile Val His Phe Asn Met Thr Lys Ala Val Glu Met Tyr Asn Ile 
        515                 520                 525             


Ala Gly Asn Trp Ser Cys Thr Ser Asp Leu Pro Ser Ser Trp Gly Tyr 
    530                 535                 540                 


Met Asn Cys Asn Cys Thr Asn Ser Ser Ser Ser Tyr Ser Gly Thr Lys 
545                 550                 555                 560 


Met Ala Cys Pro Ser Asn Arg Gly Ile Leu Arg Asn Trp Tyr Asn Pro 
                565                 570                 575     


Val Ala Gly Leu Arg Gln Ser Leu Glu Gln Tyr Gln Val Val Lys Gln 
            580                 585                 590         


Pro Asp Tyr Leu Leu Val Pro Glu Glu Val Met Glu Tyr Lys Pro Arg 
        595                 600                 605             


Arg Lys Arg Ala Ala Ile His Val Met Leu Ala Leu Ala Thr Val Leu 
    610                 615                 620                 


Ser Ile Ala Gly Ala Gly Thr Gly Ala Thr Ala Ile Gly Met Val Thr 
625                 630                 635                 640 


Gln Tyr His Gln Val Leu Ala Thr His Gln Glu Ala Ile Glu Lys Val 
                645                 650                 655     


Thr Gly Ala Leu Lys Ile Asn Asn Leu Arg Leu Val Thr Leu Glu His 
            660                 665                 670         


Gln Val Leu Val Ile Gly Leu Lys Val Glu Ala Met Glu Lys Phe Phe 
        675                 680                 685             


Tyr Thr Ala Phe Ala Met Gln Glu Leu Gly Cys Asn Gln Asn Gln Phe 
    690                 695                 700                 


Phe Cys Lys Ile Pro Leu Glu Leu Trp Thr Arg Tyr Asn Met Thr Ile 
705                 710                 715                 720 


Asn Gln Thr Ile Trp Asn His Gly Asn Ile Thr Leu Gly Glu Trp Tyr 
                725                 730                 735     


Asn Gln Thr Lys Asp Leu Gln Gln Lys Phe Tyr Glu Ile Ile Met Asp 
            740                 745                 750         


Ile Glu Gln Asn Asn Val Gln Gly Lys Thr Gly Ile Gln Gln Leu Gln 
        755                 760                 765             


Lys Trp Glu Asp Trp Val Arg Trp Ile Gly Asn Ile Pro Gln Tyr Leu 
    770                 775                 780                 


Lys Gly Leu Leu Gly Gly Ile Leu Gly Ile Gly Leu Gly Val Leu Leu 
785                 790                 795                 800 


Leu Ile Leu Cys Leu Pro Thr Leu Val Asp Cys Ile Arg Asn Cys Ile 
                805                 810                 815     


His Lys Ile Leu Gly Tyr Thr Val Ile Ala Met Pro Glu Val Glu Gly 
            820                 825                 830         


Glu Glu Ile Gln Pro Gln Met Glu Leu Arg Arg Asn Gly Arg Gln Cys 
        835                 840                 845             


Gly Met Ser Glu Lys Glu Glu Glu 
    850                 855     


<210>  324
<211>  856
<212>  PRT
<213>  Artificial sequence

<220>
<223>  Mutated sequence

<400>  324

Met Ala Glu Gly Phe Ala Ala Asn Arg Gln Trp Ile Gly Pro Glu Glu 
1               5                   10                  15      


Ala Glu Glu Leu Leu Asp Phe Asp Ile Ala Thr Gln Met Ser Glu Glu 
            20                  25                  30          


Gly Pro Leu Asn Pro Gly Val Asn Pro Phe Arg Val Pro Gly Ile Thr 
        35                  40                  45              


Glu Lys Glu Lys Gln Asn Tyr Cys Asn Ile Leu Gln Pro Lys Leu Gln 
    50                  55                  60                  


Asp Leu Arg Asn Glu Ile Gln Glu Val Lys Leu Glu Glu Gly Asn Ala 
65                  70                  75                  80  


Gly Lys Phe Arg Arg Ala Arg Phe Leu Arg Tyr Ser Asp Glu Arg Val 
                85                  90                  95      


Leu Ser Leu Val His Ala Phe Ile Gly Tyr Cys Ile Tyr Leu Gly Asn 
            100                 105                 110         


Arg Asn Lys Leu Gly Ser Leu Arg His Asp Ile Asp Ile Glu Ala Pro 
        115                 120                 125             


Gln Glu Glu Cys Tyr Asn Asn Arg Glu Lys Gly Thr Thr Asp Asn Ile 
    130                 135                 140                 


Lys Tyr Gly Arg Arg Cys Cys Leu Gly Thr Val Thr Leu Tyr Leu Ile 
145                 150                 155                 160 


Leu Phe Thr Gly Val Ile Val Tyr Ser Gln Thr Ala Gly Ala Gln Val 
                165                 170                 175     


Val Trp Arg Leu Pro Pro Leu Val Val Pro Val Glu Glu Ser Glu Ile 
            180                 185                 190         


Ile Phe Trp Asp Cys Trp Ala Pro Glu Glu Pro Ala Cys Gln Asp Phe 
        195                 200                 205             


Leu Gly Ala Met Ile His Leu Lys Ala Lys Thr Asn Ile Ser Ile Arg 
    210                 215                 220                 


Glu Gly Pro Thr Leu Gly Asn Trp Ala Arg Glu Ile Trp Ala Thr Leu 
225                 230                 235                 240 


Phe Lys Lys Ala Thr Arg Gln Cys Arg Arg Gly Arg Ile Trp Lys Arg 
                245                 250                 255     


Trp Asn Glu Thr Ile Thr Gly Pro Ser Gly Cys Ala Asn Asn Thr Cys 
            260                 265                 270         


Tyr Asn Val Ser Val Ile Val Pro Asp Tyr Gln Cys Tyr Leu Asp Arg 
        275                 280                 285             


Val Asp Thr Trp Leu Gln Gly Lys Ile Asn Ile Ser Leu Cys Leu Thr 
    290                 295                 300                 


Gly Gly Lys Met Leu Tyr Asn Lys Val Thr Lys Gln Leu Ser Tyr Cys 
305                 310                 315                 320 


Thr Asp Pro Leu Gln Ile Pro Leu Ile Asn Tyr Thr Phe Gly Pro Asn 
                325                 330                 335     


Gln Thr Cys Met Trp Asn Thr Ser Gln Ile Gln Asp Pro Glu Ile Pro 
            340                 345                 350         


Lys Cys Gly Trp Trp Asn Gln Met Ala Tyr Tyr Asn Ser Cys Lys Trp 
        355                 360                 365             


Glu Glu Ala Lys Val Lys Phe His Cys Gln Arg Thr Gln Ser Gln Pro 
    370                 375                 380                 


Gly Ser Trp Phe Arg Ala Ile Ser Ser Trp Lys Gln Arg Asn Arg Trp 
385                 390                 395                 400 


Glu Trp Arg Pro Asp Phe Lys Ser Lys Lys Val Lys Ile Ser Leu Pro 
                405                 410                 415     


Cys Asn Ser Thr Lys Asn Leu Thr Phe Ala Met Arg Ser Ser Gly Asp 
            420                 425                 430         


Tyr Gly Glu Val Thr Gly Ala Trp Ile Glu Phe Gly Cys His Arg Asn 
        435                 440                 445             


Lys Ser Asn Leu His Thr Glu Ala Arg Phe Arg Ile Arg Cys Arg Trp 
    450                 455                 460                 


Asn Val Gly Ser Asp Thr Ser Leu Ile Asp Thr Cys Gly Asn Thr Pro 
465                 470                 475                 480 


Asn Val Ser Gly Ala Asn Pro Val Asp Cys Thr Met Tyr Ser Asn Lys 
                485                 490                 495     


Met Tyr Asn Cys Ser Leu Gln Asn Gly Phe Thr Met Lys Val Asp Asp 
            500                 505                 510         


Leu Ile Val His Phe Asn Met Thr Lys Ala Val Glu Met Tyr Asn Ile 
        515                 520                 525             


Ala Gly Asn Trp Ser Cys Thr Ser Asp Leu Pro Ser Ser Trp Gly Tyr 
    530                 535                 540                 


Met Asn Cys Asn Cys Thr Asn Ser Ser Ser Ser Tyr Ser Gly Thr Lys 
545                 550                 555                 560 


Met Ala Cys Pro Ser Asn Arg Gly Ile Leu Arg Asn Trp Tyr Asn Pro 
                565                 570                 575     


Val Ala Gly Leu Arg Gln Ser Leu Glu Gln Tyr Gln Val Val Lys Gln 
            580                 585                 590         


Pro Asp Tyr Leu Leu Val Pro Glu Glu Val Met Glu Tyr Lys Pro Arg 
        595                 600                 605             


Arg Lys Arg Ala Ala Ile His Val Met Leu Ala Leu Ala Thr Val Leu 
    610                 615                 620                 


Ser Ile Ala Gly Ala Gly Thr Gly Ala Thr Ala Ile Gly Met Val Thr 
625                 630                 635                 640 


Gln Tyr His Gln Val Leu Ala Thr His Gln Glu Ala Ile Glu Lys Val 
                645                 650                 655     


Thr Gly Ala Leu Lys Ile Asn Asn Leu Arg Leu Val Thr Leu Glu His 
            660                 665                 670         


Gln Val Leu Val Ile Gly Leu Lys Val Glu Ala Met Arg Lys Phe Leu 
        675                 680                 685             


Tyr Thr Ala Phe Ala Met Gln Glu Leu Gly Cys Asn Gln Asn Gln Phe 
    690                 695                 700                 


Phe Cys Lys Ile Pro Leu Glu Leu Trp Thr Arg Tyr Asn Met Thr Ile 
705                 710                 715                 720 


Asn Gln Thr Ile Trp Asn His Gly Asn Ile Thr Leu Gly Glu Trp Tyr 
                725                 730                 735     


Asn Gln Thr Lys Asp Leu Gln Gln Lys Phe Tyr Glu Ile Ile Met Asp 
            740                 745                 750         


Ile Glu Gln Asn Asn Val Gln Gly Lys Thr Gly Ile Gln Gln Leu Gln 
        755                 760                 765             


Lys Trp Glu Asp Trp Val Arg Trp Ile Gly Asn Ile Pro Gln Tyr Leu 
    770                 775                 780                 


Lys Gly Leu Leu Gly Gly Ile Leu Gly Ile Gly Leu Gly Val Leu Leu 
785                 790                 795                 800 


Leu Ile Leu Cys Leu Pro Thr Leu Val Asp Cys Ile Arg Asn Cys Ile 
                805                 810                 815     


His Lys Ile Leu Gly Tyr Thr Val Ile Ala Met Pro Glu Val Glu Gly 
            820                 825                 830         


Glu Glu Ile Gln Pro Gln Met Glu Leu Arg Arg Asn Gly Arg Gln Cys 
        835                 840                 845             


Gly Met Ser Glu Lys Glu Glu Glu 
    850                 855     


<210>  325
<211>  856
<212>  PRT
<213>  Artificial sequence

<220>
<223>  Mutated sequence

<400>  325

Met Ala Glu Gly Phe Ala Ala Asn Arg Gln Trp Ile Gly Pro Glu Glu 
1               5                   10                  15      


Ala Glu Glu Leu Leu Asp Phe Asp Ile Ala Thr Gln Met Ser Glu Glu 
            20                  25                  30          


Gly Pro Leu Asn Pro Gly Val Asn Pro Phe Arg Val Pro Gly Ile Thr 
        35                  40                  45              


Glu Lys Glu Lys Gln Asn Tyr Cys Asn Ile Leu Gln Pro Lys Leu Gln 
    50                  55                  60                  


Asp Leu Arg Asn Glu Ile Gln Glu Val Lys Leu Glu Glu Gly Asn Ala 
65                  70                  75                  80  


Gly Lys Phe Arg Arg Ala Arg Phe Leu Arg Tyr Ser Asp Glu Arg Val 
                85                  90                  95      


Leu Ser Leu Val His Ala Phe Ile Gly Tyr Cys Ile Tyr Leu Gly Asn 
            100                 105                 110         


Arg Asn Lys Leu Gly Ser Leu Arg His Asp Ile Asp Ile Glu Ala Pro 
        115                 120                 125             


Gln Glu Glu Cys Tyr Asn Asn Arg Glu Lys Gly Thr Thr Asp Asn Ile 
    130                 135                 140                 


Lys Tyr Gly Arg Arg Cys Cys Leu Gly Thr Val Thr Leu Tyr Leu Ile 
145                 150                 155                 160 


Leu Phe Thr Gly Val Ile Val Tyr Ser Gln Thr Ala Gly Ala Gln Val 
                165                 170                 175     


Val Trp Arg Leu Pro Pro Leu Val Val Pro Val Glu Glu Ser Glu Ile 
            180                 185                 190         


Ile Phe Trp Asp Cys Trp Ala Pro Glu Glu Pro Ala Cys Gln Asp Phe 
        195                 200                 205             


Leu Gly Ala Met Ile His Leu Lys Ala Lys Thr Asn Ile Ser Ile Arg 
    210                 215                 220                 


Glu Gly Pro Thr Leu Gly Asn Trp Ala Arg Glu Ile Trp Ala Thr Leu 
225                 230                 235                 240 


Phe Lys Lys Ala Thr Arg Gln Cys Arg Arg Gly Arg Ile Trp Lys Arg 
                245                 250                 255     


Trp Asn Glu Thr Ile Thr Gly Pro Ser Gly Cys Ala Asn Asn Thr Cys 
            260                 265                 270         


Tyr Asn Val Ser Val Ile Val Pro Asp Tyr Gln Cys Tyr Leu Asp Arg 
        275                 280                 285             


Val Asp Thr Trp Leu Gln Gly Lys Ile Asn Ile Ser Leu Cys Leu Thr 
    290                 295                 300                 


Gly Gly Lys Met Leu Tyr Asn Lys Val Thr Lys Gln Leu Ser Tyr Cys 
305                 310                 315                 320 


Thr Asp Pro Leu Gln Ile Pro Leu Ile Asn Tyr Thr Phe Gly Pro Asn 
                325                 330                 335     


Gln Thr Cys Met Trp Asn Thr Ser Gln Ile Gln Asp Pro Glu Ile Pro 
            340                 345                 350         


Lys Cys Gly Trp Trp Asn Gln Met Ala Tyr Tyr Asn Ser Cys Lys Trp 
        355                 360                 365             


Glu Glu Ala Lys Val Lys Phe His Cys Gln Arg Thr Gln Ser Gln Pro 
    370                 375                 380                 


Gly Ser Trp Phe Arg Ala Ile Ser Ser Trp Lys Gln Arg Asn Arg Trp 
385                 390                 395                 400 


Glu Trp Arg Pro Asp Phe Lys Ser Lys Lys Val Lys Ile Ser Leu Pro 
                405                 410                 415     


Cys Asn Ser Thr Lys Asn Leu Thr Phe Ala Met Arg Ser Ser Gly Asp 
            420                 425                 430         


Tyr Gly Glu Val Thr Gly Ala Trp Ile Glu Phe Gly Cys His Arg Asn 
        435                 440                 445             


Lys Ser Asn Leu His Thr Glu Ala Arg Phe Arg Ile Arg Cys Arg Trp 
    450                 455                 460                 


Asn Val Gly Ser Asp Thr Ser Leu Ile Asp Thr Cys Gly Asn Thr Pro 
465                 470                 475                 480 


Asn Val Ser Gly Ala Asn Pro Val Asp Cys Thr Met Tyr Ser Asn Lys 
                485                 490                 495     


Met Tyr Asn Cys Ser Leu Gln Asn Gly Phe Thr Met Lys Val Asp Asp 
            500                 505                 510         


Leu Ile Val His Phe Asn Met Thr Lys Ala Val Glu Met Tyr Asn Ile 
        515                 520                 525             


Ala Gly Asn Trp Ser Cys Thr Ser Asp Leu Pro Ser Ser Trp Gly Tyr 
    530                 535                 540                 


Met Asn Cys Asn Cys Thr Asn Ser Ser Ser Ser Tyr Ser Gly Thr Lys 
545                 550                 555                 560 


Met Ala Cys Pro Ser Asn Arg Gly Ile Leu Arg Asn Trp Tyr Asn Pro 
                565                 570                 575     


Val Ala Gly Leu Arg Gln Ser Leu Glu Gln Tyr Gln Val Val Lys Gln 
            580                 585                 590         


Pro Asp Tyr Leu Leu Val Pro Glu Glu Val Met Glu Tyr Lys Pro Arg 
        595                 600                 605             


Arg Lys Arg Ala Ala Ile His Val Met Leu Ala Leu Ala Thr Val Leu 
    610                 615                 620                 


Ser Ile Ala Gly Ala Gly Thr Gly Ala Thr Ala Ile Gly Met Val Thr 
625                 630                 635                 640 


Gln Tyr His Gln Val Leu Ala Thr His Gln Glu Ala Ile Glu Lys Val 
                645                 650                 655     


Thr Gly Ala Leu Lys Ile Asn Asn Leu Arg Leu Val Thr Leu Glu His 
            660                 665                 670         


Gln Val Leu Val Ile Gly Leu Lys Val Glu Ala Met Gly Lys Phe Leu 
        675                 680                 685             


Tyr Thr Ala Phe Ala Met Gln Glu Leu Gly Cys Asn Gln Asn Gln Phe 
    690                 695                 700                 


Phe Cys Lys Ile Pro Leu Glu Leu Trp Thr Arg Tyr Asn Met Thr Ile 
705                 710                 715                 720 


Asn Gln Thr Ile Trp Asn His Gly Asn Ile Thr Leu Gly Glu Trp Tyr 
                725                 730                 735     


Asn Gln Thr Lys Asp Leu Gln Gln Lys Phe Tyr Glu Ile Ile Met Asp 
            740                 745                 750         


Ile Glu Gln Asn Asn Val Gln Gly Lys Thr Gly Ile Gln Gln Leu Gln 
        755                 760                 765             


Lys Trp Glu Asp Trp Val Arg Trp Ile Gly Asn Ile Pro Gln Tyr Leu 
    770                 775                 780                 


Lys Gly Leu Leu Gly Gly Ile Leu Gly Ile Gly Leu Gly Val Leu Leu 
785                 790                 795                 800 


Leu Ile Leu Cys Leu Pro Thr Leu Val Asp Cys Ile Arg Asn Cys Ile 
                805                 810                 815     


His Lys Ile Leu Gly Tyr Thr Val Ile Ala Met Pro Glu Val Glu Gly 
            820                 825                 830         


Glu Glu Ile Gln Pro Gln Met Glu Leu Arg Arg Asn Gly Arg Gln Cys 
        835                 840                 845             


Gly Met Ser Glu Lys Glu Glu Glu 
    850                 855     


<210>  326
<211>  856
<212>  PRT
<213>  Artificial sequence

<220>
<223>  Mutated sequence

<400>  326

Met Ala Glu Gly Phe Ala Ala Asn Arg Gln Trp Ile Gly Pro Glu Glu 
1               5                   10                  15      


Ala Glu Glu Leu Leu Asp Phe Asp Ile Ala Thr Gln Met Ser Glu Glu 
            20                  25                  30          


Gly Pro Leu Asn Pro Gly Val Asn Pro Phe Arg Val Pro Gly Ile Thr 
        35                  40                  45              


Glu Lys Glu Lys Gln Asn Tyr Cys Asn Ile Leu Gln Pro Lys Leu Gln 
    50                  55                  60                  


Asp Leu Arg Asn Glu Ile Gln Glu Val Lys Leu Glu Glu Gly Asn Ala 
65                  70                  75                  80  


Gly Lys Phe Arg Arg Ala Arg Phe Leu Arg Tyr Ser Asp Glu Arg Val 
                85                  90                  95      


Leu Ser Leu Val His Ala Phe Ile Gly Tyr Cys Ile Tyr Leu Gly Asn 
            100                 105                 110         


Arg Asn Lys Leu Gly Ser Leu Arg His Asp Ile Asp Ile Glu Ala Pro 
        115                 120                 125             


Gln Glu Glu Cys Tyr Asn Asn Arg Glu Lys Gly Thr Thr Asp Asn Ile 
    130                 135                 140                 


Lys Tyr Gly Arg Arg Cys Cys Leu Gly Thr Val Thr Leu Tyr Leu Ile 
145                 150                 155                 160 


Leu Phe Thr Gly Val Ile Val Tyr Ser Gln Thr Ala Gly Ala Gln Val 
                165                 170                 175     


Val Trp Arg Leu Pro Pro Leu Val Val Pro Val Glu Glu Ser Glu Ile 
            180                 185                 190         


Ile Phe Trp Asp Cys Trp Ala Pro Glu Glu Pro Ala Cys Gln Asp Phe 
        195                 200                 205             


Leu Gly Ala Met Ile His Leu Lys Ala Lys Thr Asn Ile Ser Ile Arg 
    210                 215                 220                 


Glu Gly Pro Thr Leu Gly Asn Trp Ala Arg Glu Ile Trp Ala Thr Leu 
225                 230                 235                 240 


Phe Lys Lys Ala Thr Arg Gln Cys Arg Arg Gly Arg Ile Trp Lys Arg 
                245                 250                 255     


Trp Asn Glu Thr Ile Thr Gly Pro Ser Gly Cys Ala Asn Asn Thr Cys 
            260                 265                 270         


Tyr Asn Val Ser Val Ile Val Pro Asp Tyr Gln Cys Tyr Leu Asp Arg 
        275                 280                 285             


Val Asp Thr Trp Leu Gln Gly Lys Ile Asn Ile Ser Leu Cys Leu Thr 
    290                 295                 300                 


Gly Gly Lys Met Leu Tyr Asn Lys Val Thr Lys Gln Leu Ser Tyr Cys 
305                 310                 315                 320 


Thr Asp Pro Leu Gln Ile Pro Leu Ile Asn Tyr Thr Phe Gly Pro Asn 
                325                 330                 335     


Gln Thr Cys Met Trp Asn Thr Ser Gln Ile Gln Asp Pro Glu Ile Pro 
            340                 345                 350         


Lys Cys Gly Trp Trp Asn Gln Met Ala Tyr Tyr Asn Ser Cys Lys Trp 
        355                 360                 365             


Glu Glu Ala Lys Val Lys Phe His Cys Gln Arg Thr Gln Ser Gln Pro 
    370                 375                 380                 


Gly Ser Trp Phe Arg Ala Ile Ser Ser Trp Lys Gln Arg Asn Arg Trp 
385                 390                 395                 400 


Glu Trp Arg Pro Asp Phe Lys Ser Lys Lys Val Lys Ile Ser Leu Pro 
                405                 410                 415     


Cys Asn Ser Thr Lys Asn Leu Thr Phe Ala Met Arg Ser Ser Gly Asp 
            420                 425                 430         


Tyr Gly Glu Val Thr Gly Ala Trp Ile Glu Phe Gly Cys His Arg Asn 
        435                 440                 445             


Lys Ser Asn Leu His Thr Glu Ala Arg Phe Arg Ile Arg Cys Arg Trp 
    450                 455                 460                 


Asn Val Gly Ser Asp Thr Ser Leu Ile Asp Thr Cys Gly Asn Thr Pro 
465                 470                 475                 480 


Asn Val Ser Gly Ala Asn Pro Val Asp Cys Thr Met Tyr Ser Asn Lys 
                485                 490                 495     


Met Tyr Asn Cys Ser Leu Gln Asn Gly Phe Thr Met Lys Val Asp Asp 
            500                 505                 510         


Leu Ile Val His Phe Asn Met Thr Lys Ala Val Glu Met Tyr Asn Ile 
        515                 520                 525             


Ala Gly Asn Trp Ser Cys Thr Ser Asp Leu Pro Ser Ser Trp Gly Tyr 
    530                 535                 540                 


Met Asn Cys Asn Cys Thr Asn Ser Ser Ser Ser Tyr Ser Gly Thr Lys 
545                 550                 555                 560 


Met Ala Cys Pro Ser Asn Arg Gly Ile Leu Arg Asn Trp Tyr Asn Pro 
                565                 570                 575     


Val Ala Gly Leu Arg Gln Ser Leu Glu Gln Tyr Gln Val Val Lys Gln 
            580                 585                 590         


Pro Asp Tyr Leu Leu Val Pro Glu Glu Val Met Glu Tyr Lys Pro Arg 
        595                 600                 605             


Arg Lys Arg Ala Ala Ile His Val Met Leu Ala Leu Ala Thr Val Leu 
    610                 615                 620                 


Ser Ile Ala Gly Ala Gly Thr Gly Ala Thr Ala Ile Gly Met Val Thr 
625                 630                 635                 640 


Gln Tyr His Gln Val Leu Ala Thr His Gln Glu Ala Ile Glu Lys Val 
                645                 650                 655     


Thr Gly Ala Leu Lys Ile Asn Asn Leu Arg Leu Val Thr Leu Glu His 
            660                 665                 670         


Gln Val Leu Val Ile Gly Leu Lys Val Glu Ala Met Leu Lys Phe Leu 
        675                 680                 685             


Tyr Thr Ala Phe Ala Met Gln Glu Leu Gly Cys Asn Gln Asn Gln Phe 
    690                 695                 700                 


Phe Cys Lys Ile Pro Leu Glu Leu Trp Thr Arg Tyr Asn Met Thr Ile 
705                 710                 715                 720 


Asn Gln Thr Ile Trp Asn His Gly Asn Ile Thr Leu Gly Glu Trp Tyr 
                725                 730                 735     


Asn Gln Thr Lys Asp Leu Gln Gln Lys Phe Tyr Glu Ile Ile Met Asp 
            740                 745                 750         


Ile Glu Gln Asn Asn Val Gln Gly Lys Thr Gly Ile Gln Gln Leu Gln 
        755                 760                 765             


Lys Trp Glu Asp Trp Val Arg Trp Ile Gly Asn Ile Pro Gln Tyr Leu 
    770                 775                 780                 


Lys Gly Leu Leu Gly Gly Ile Leu Gly Ile Gly Leu Gly Val Leu Leu 
785                 790                 795                 800 


Leu Ile Leu Cys Leu Pro Thr Leu Val Asp Cys Ile Arg Asn Cys Ile 
                805                 810                 815     


His Lys Ile Leu Gly Tyr Thr Val Ile Ala Met Pro Glu Val Glu Gly 
            820                 825                 830         


Glu Glu Ile Gln Pro Gln Met Glu Leu Arg Arg Asn Gly Arg Gln Cys 
        835                 840                 845             


Gly Met Ser Glu Lys Glu Glu Glu 
    850                 855     


<210>  327
<211>  856
<212>  PRT
<213>  Artificial sequence

<220>
<223>  Mutated sequence

<400>  327

Met Ala Glu Gly Phe Ala Ala Asn Arg Gln Trp Ile Gly Pro Glu Glu 
1               5                   10                  15      


Ala Glu Glu Leu Leu Asp Phe Asp Ile Ala Thr Gln Met Ser Glu Glu 
            20                  25                  30          


Gly Pro Leu Asn Pro Gly Val Asn Pro Phe Arg Val Pro Gly Ile Thr 
        35                  40                  45              


Glu Lys Glu Lys Gln Asn Tyr Cys Asn Ile Leu Gln Pro Lys Leu Gln 
    50                  55                  60                  


Asp Leu Arg Asn Glu Ile Gln Glu Val Lys Leu Glu Glu Gly Asn Ala 
65                  70                  75                  80  


Gly Lys Phe Arg Arg Ala Arg Phe Leu Arg Tyr Ser Asp Glu Arg Val 
                85                  90                  95      


Leu Ser Leu Val His Ala Phe Ile Gly Tyr Cys Ile Tyr Leu Gly Asn 
            100                 105                 110         


Arg Asn Lys Leu Gly Ser Leu Arg His Asp Ile Asp Ile Glu Ala Pro 
        115                 120                 125             


Gln Glu Glu Cys Tyr Asn Asn Arg Glu Lys Gly Thr Thr Asp Asn Ile 
    130                 135                 140                 


Lys Tyr Gly Arg Arg Cys Cys Leu Gly Thr Val Thr Leu Tyr Leu Ile 
145                 150                 155                 160 


Leu Phe Thr Gly Val Ile Val Tyr Ser Gln Thr Ala Gly Ala Gln Val 
                165                 170                 175     


Val Trp Arg Leu Pro Pro Leu Val Val Pro Val Glu Glu Ser Glu Ile 
            180                 185                 190         


Ile Phe Trp Asp Cys Trp Ala Pro Glu Glu Pro Ala Cys Gln Asp Phe 
        195                 200                 205             


Leu Gly Ala Met Ile His Leu Lys Ala Lys Thr Asn Ile Ser Ile Arg 
    210                 215                 220                 


Glu Gly Pro Thr Leu Gly Asn Trp Ala Arg Glu Ile Trp Ala Thr Leu 
225                 230                 235                 240 


Phe Lys Lys Ala Thr Arg Gln Cys Arg Arg Gly Arg Ile Trp Lys Arg 
                245                 250                 255     


Trp Asn Glu Thr Ile Thr Gly Pro Ser Gly Cys Ala Asn Asn Thr Cys 
            260                 265                 270         


Tyr Asn Val Ser Val Ile Val Pro Asp Tyr Gln Cys Tyr Leu Asp Arg 
        275                 280                 285             


Val Asp Thr Trp Leu Gln Gly Lys Ile Asn Ile Ser Leu Cys Leu Thr 
    290                 295                 300                 


Gly Gly Lys Met Leu Tyr Asn Lys Val Thr Lys Gln Leu Ser Tyr Cys 
305                 310                 315                 320 


Thr Asp Pro Leu Gln Ile Pro Leu Ile Asn Tyr Thr Phe Gly Pro Asn 
                325                 330                 335     


Gln Thr Cys Met Trp Asn Thr Ser Gln Ile Gln Asp Pro Glu Ile Pro 
            340                 345                 350         


Lys Cys Gly Trp Trp Asn Gln Met Ala Tyr Tyr Asn Ser Cys Lys Trp 
        355                 360                 365             


Glu Glu Ala Lys Val Lys Phe His Cys Gln Arg Thr Gln Ser Gln Pro 
    370                 375                 380                 


Gly Ser Trp Phe Arg Ala Ile Ser Ser Trp Lys Gln Arg Asn Arg Trp 
385                 390                 395                 400 


Glu Trp Arg Pro Asp Phe Lys Ser Lys Lys Val Lys Ile Ser Leu Pro 
                405                 410                 415     


Cys Asn Ser Thr Lys Asn Leu Thr Phe Ala Met Arg Ser Ser Gly Asp 
            420                 425                 430         


Tyr Gly Glu Val Thr Gly Ala Trp Ile Glu Phe Gly Cys His Arg Asn 
        435                 440                 445             


Lys Ser Asn Leu His Thr Glu Ala Arg Phe Arg Ile Arg Cys Arg Trp 
    450                 455                 460                 


Asn Val Gly Ser Asp Thr Ser Leu Ile Asp Thr Cys Gly Asn Thr Pro 
465                 470                 475                 480 


Asn Val Ser Gly Ala Asn Pro Val Asp Cys Thr Met Tyr Ser Asn Lys 
                485                 490                 495     


Met Tyr Asn Cys Ser Leu Gln Asn Gly Phe Thr Met Lys Val Asp Asp 
            500                 505                 510         


Leu Ile Val His Phe Asn Met Thr Lys Ala Val Glu Met Tyr Asn Ile 
        515                 520                 525             


Ala Gly Asn Trp Ser Cys Thr Ser Asp Leu Pro Ser Ser Trp Gly Tyr 
    530                 535                 540                 


Met Asn Cys Asn Cys Thr Asn Ser Ser Ser Ser Tyr Ser Gly Thr Lys 
545                 550                 555                 560 


Met Ala Cys Pro Ser Asn Arg Gly Ile Leu Arg Asn Trp Tyr Asn Pro 
                565                 570                 575     


Val Ala Gly Leu Arg Gln Ser Leu Glu Gln Tyr Gln Val Val Lys Gln 
            580                 585                 590         


Pro Asp Tyr Leu Leu Val Pro Glu Glu Val Met Glu Tyr Lys Pro Arg 
        595                 600                 605             


Arg Lys Arg Ala Ala Ile His Val Met Leu Ala Leu Ala Thr Val Leu 
    610                 615                 620                 


Ser Ile Ala Gly Ala Gly Thr Gly Ala Thr Ala Ile Gly Met Val Thr 
625                 630                 635                 640 


Gln Tyr His Gln Val Leu Ala Thr His Gln Glu Ala Ile Glu Lys Val 
                645                 650                 655     


Thr Gly Ala Leu Lys Ile Asn Asn Leu Arg Leu Val Thr Leu Glu His 
            660                 665                 670         


Gln Val Leu Val Ile Gly Leu Lys Val Glu Ala Met Ala Lys Phe Leu 
        675                 680                 685             


Tyr Thr Ala Phe Ala Met Gln Glu Leu Gly Cys Asn Gln Asn Gln Phe 
    690                 695                 700                 


Phe Cys Lys Ile Pro Leu Glu Leu Trp Thr Arg Tyr Asn Met Thr Ile 
705                 710                 715                 720 


Asn Gln Thr Ile Trp Asn His Gly Asn Ile Thr Leu Gly Glu Trp Tyr 
                725                 730                 735     


Asn Gln Thr Lys Asp Leu Gln Gln Lys Phe Tyr Glu Ile Ile Met Asp 
            740                 745                 750         


Ile Glu Gln Asn Asn Val Gln Gly Lys Thr Gly Ile Gln Gln Leu Gln 
        755                 760                 765             


Lys Trp Glu Asp Trp Val Arg Trp Ile Gly Asn Ile Pro Gln Tyr Leu 
    770                 775                 780                 


Lys Gly Leu Leu Gly Gly Ile Leu Gly Ile Gly Leu Gly Val Leu Leu 
785                 790                 795                 800 


Leu Ile Leu Cys Leu Pro Thr Leu Val Asp Cys Ile Arg Asn Cys Ile 
                805                 810                 815     


His Lys Ile Leu Gly Tyr Thr Val Ile Ala Met Pro Glu Val Glu Gly 
            820                 825                 830         


Glu Glu Ile Gln Pro Gln Met Glu Leu Arg Arg Asn Gly Arg Gln Cys 
        835                 840                 845             


Gly Met Ser Glu Lys Glu Glu Glu 
    850                 855     


<210>  328
<211>  856
<212>  PRT
<213>  Artificial sequence

<220>
<223>  Mutated sequence

<400>  328

Met Ala Glu Gly Phe Ala Ala Asn Arg Gln Trp Ile Gly Pro Glu Glu 
1               5                   10                  15      


Ala Glu Glu Leu Leu Asp Phe Asp Ile Ala Thr Gln Met Ser Glu Glu 
            20                  25                  30          


Gly Pro Leu Asn Pro Gly Val Asn Pro Phe Arg Val Pro Gly Ile Thr 
        35                  40                  45              


Glu Lys Glu Lys Gln Asn Tyr Cys Asn Ile Leu Gln Pro Lys Leu Gln 
    50                  55                  60                  


Asp Leu Arg Asn Glu Ile Gln Glu Val Lys Leu Glu Glu Gly Asn Ala 
65                  70                  75                  80  


Gly Lys Phe Arg Arg Ala Arg Phe Leu Arg Tyr Ser Asp Glu Arg Val 
                85                  90                  95      


Leu Ser Leu Val His Ala Phe Ile Gly Tyr Cys Ile Tyr Leu Gly Asn 
            100                 105                 110         


Arg Asn Lys Leu Gly Ser Leu Arg His Asp Ile Asp Ile Glu Ala Pro 
        115                 120                 125             


Gln Glu Glu Cys Tyr Asn Asn Arg Glu Lys Gly Thr Thr Asp Asn Ile 
    130                 135                 140                 


Lys Tyr Gly Arg Arg Cys Cys Leu Gly Thr Val Thr Leu Tyr Leu Ile 
145                 150                 155                 160 


Leu Phe Thr Gly Val Ile Val Tyr Ser Gln Thr Ala Gly Ala Gln Val 
                165                 170                 175     


Val Trp Arg Leu Pro Pro Leu Val Val Pro Val Glu Glu Ser Glu Ile 
            180                 185                 190         


Ile Phe Trp Asp Cys Trp Ala Pro Glu Glu Pro Ala Cys Gln Asp Phe 
        195                 200                 205             


Leu Gly Ala Met Ile His Leu Lys Ala Lys Thr Asn Ile Ser Ile Arg 
    210                 215                 220                 


Glu Gly Pro Thr Leu Gly Asn Trp Ala Arg Glu Ile Trp Ala Thr Leu 
225                 230                 235                 240 


Phe Lys Lys Ala Thr Arg Gln Cys Arg Arg Gly Arg Ile Trp Lys Arg 
                245                 250                 255     


Trp Asn Glu Thr Ile Thr Gly Pro Ser Gly Cys Ala Asn Asn Thr Cys 
            260                 265                 270         


Tyr Asn Val Ser Val Ile Val Pro Asp Tyr Gln Cys Tyr Leu Asp Arg 
        275                 280                 285             


Val Asp Thr Trp Leu Gln Gly Lys Ile Asn Ile Ser Leu Cys Leu Thr 
    290                 295                 300                 


Gly Gly Lys Met Leu Tyr Asn Lys Val Thr Lys Gln Leu Ser Tyr Cys 
305                 310                 315                 320 


Thr Asp Pro Leu Gln Ile Pro Leu Ile Asn Tyr Thr Phe Gly Pro Asn 
                325                 330                 335     


Gln Thr Cys Met Trp Asn Thr Ser Gln Ile Gln Asp Pro Glu Ile Pro 
            340                 345                 350         


Lys Cys Gly Trp Trp Asn Gln Met Ala Tyr Tyr Asn Ser Cys Lys Trp 
        355                 360                 365             


Glu Glu Ala Lys Val Lys Phe His Cys Gln Arg Thr Gln Ser Gln Pro 
    370                 375                 380                 


Gly Ser Trp Phe Arg Ala Ile Ser Ser Trp Lys Gln Arg Asn Arg Trp 
385                 390                 395                 400 


Glu Trp Arg Pro Asp Phe Lys Ser Lys Lys Val Lys Ile Ser Leu Pro 
                405                 410                 415     


Cys Asn Ser Thr Lys Asn Leu Thr Phe Ala Met Arg Ser Ser Gly Asp 
            420                 425                 430         


Tyr Gly Glu Val Thr Gly Ala Trp Ile Glu Phe Gly Cys His Arg Asn 
        435                 440                 445             


Lys Ser Asn Leu His Thr Glu Ala Arg Phe Arg Ile Arg Cys Arg Trp 
    450                 455                 460                 


Asn Val Gly Ser Asp Thr Ser Leu Ile Asp Thr Cys Gly Asn Thr Pro 
465                 470                 475                 480 


Asn Val Ser Gly Ala Asn Pro Val Asp Cys Thr Met Tyr Ser Asn Lys 
                485                 490                 495     


Met Tyr Asn Cys Ser Leu Gln Asn Gly Phe Thr Met Lys Val Asp Asp 
            500                 505                 510         


Leu Ile Val His Phe Asn Met Thr Lys Ala Val Glu Met Tyr Asn Ile 
        515                 520                 525             


Ala Gly Asn Trp Ser Cys Thr Ser Asp Leu Pro Ser Ser Trp Gly Tyr 
    530                 535                 540                 


Met Asn Cys Asn Cys Thr Asn Ser Ser Ser Ser Tyr Ser Gly Thr Lys 
545                 550                 555                 560 


Met Ala Cys Pro Ser Asn Arg Gly Ile Leu Arg Asn Trp Tyr Asn Pro 
                565                 570                 575     


Val Ala Gly Leu Arg Gln Ser Leu Glu Gln Tyr Gln Val Val Lys Gln 
            580                 585                 590         


Pro Asp Tyr Leu Leu Val Pro Glu Glu Val Met Glu Tyr Lys Pro Arg 
        595                 600                 605             


Arg Lys Arg Ala Ala Ile His Val Met Leu Ala Leu Ala Thr Val Leu 
    610                 615                 620                 


Ser Ile Ala Gly Ala Gly Thr Gly Ala Thr Ala Ile Gly Met Val Thr 
625                 630                 635                 640 


Gln Tyr His Gln Val Leu Ala Thr His Gln Glu Ala Ile Glu Lys Val 
                645                 650                 655     


Thr Gly Ala Leu Lys Ile Asn Asn Leu Arg Leu Val Thr Leu Glu His 
            660                 665                 670         


Gln Val Leu Val Ile Gly Leu Lys Val Glu Ala Met Phe Lys Phe Leu 
        675                 680                 685             


Tyr Thr Ala Phe Ala Met Gln Glu Leu Gly Cys Asn Gln Asn Gln Phe 
    690                 695                 700                 


Phe Cys Lys Ile Pro Leu Glu Leu Trp Thr Arg Tyr Asn Met Thr Ile 
705                 710                 715                 720 


Asn Gln Thr Ile Trp Asn His Gly Asn Ile Thr Leu Gly Glu Trp Tyr 
                725                 730                 735     


Asn Gln Thr Lys Asp Leu Gln Gln Lys Phe Tyr Glu Ile Ile Met Asp 
            740                 745                 750         


Ile Glu Gln Asn Asn Val Gln Gly Lys Thr Gly Ile Gln Gln Leu Gln 
        755                 760                 765             


Lys Trp Glu Asp Trp Val Arg Trp Ile Gly Asn Ile Pro Gln Tyr Leu 
    770                 775                 780                 


Lys Gly Leu Leu Gly Gly Ile Leu Gly Ile Gly Leu Gly Val Leu Leu 
785                 790                 795                 800 


Leu Ile Leu Cys Leu Pro Thr Leu Val Asp Cys Ile Arg Asn Cys Ile 
                805                 810                 815     


His Lys Ile Leu Gly Tyr Thr Val Ile Ala Met Pro Glu Val Glu Gly 
            820                 825                 830         


Glu Glu Ile Gln Pro Gln Met Glu Leu Arg Arg Asn Gly Arg Gln Cys 
        835                 840                 845             


Gly Met Ser Glu Lys Glu Glu Glu 
    850                 855     


<210>  329
<211>  856
<212>  PRT
<213>  Artificial sequence

<220>
<223>  Mutated sequence

<400>  329

Met Ala Glu Gly Phe Ala Ala Asn Arg Gln Trp Ile Gly Pro Glu Glu 
1               5                   10                  15      


Ala Glu Glu Leu Leu Asp Phe Asp Ile Ala Thr Gln Met Ser Glu Glu 
            20                  25                  30          


Gly Pro Leu Asn Pro Gly Val Asn Pro Phe Arg Val Pro Gly Ile Thr 
        35                  40                  45              


Glu Lys Glu Lys Gln Asn Tyr Cys Asn Ile Leu Gln Pro Lys Leu Gln 
    50                  55                  60                  


Asp Leu Arg Asn Glu Ile Gln Glu Val Lys Leu Glu Glu Gly Asn Ala 
65                  70                  75                  80  


Gly Lys Phe Arg Arg Ala Arg Phe Leu Arg Tyr Ser Asp Glu Arg Val 
                85                  90                  95      


Leu Ser Leu Val His Ala Phe Ile Gly Tyr Cys Ile Tyr Leu Gly Asn 
            100                 105                 110         


Arg Asn Lys Leu Gly Ser Leu Arg His Asp Ile Asp Ile Glu Ala Pro 
        115                 120                 125             


Gln Glu Glu Cys Tyr Asn Asn Arg Glu Lys Gly Thr Thr Asp Asn Ile 
    130                 135                 140                 


Lys Tyr Gly Arg Arg Cys Cys Leu Gly Thr Val Thr Leu Tyr Leu Ile 
145                 150                 155                 160 


Leu Phe Thr Gly Val Ile Val Tyr Ser Gln Thr Ala Gly Ala Gln Val 
                165                 170                 175     


Val Trp Arg Leu Pro Pro Leu Val Val Pro Val Glu Glu Ser Glu Ile 
            180                 185                 190         


Ile Phe Trp Asp Cys Trp Ala Pro Glu Glu Pro Ala Cys Gln Asp Phe 
        195                 200                 205             


Leu Gly Ala Met Ile His Leu Lys Ala Lys Thr Asn Ile Ser Ile Arg 
    210                 215                 220                 


Glu Gly Pro Thr Leu Gly Asn Trp Ala Arg Glu Ile Trp Ala Thr Leu 
225                 230                 235                 240 


Phe Lys Lys Ala Thr Arg Gln Cys Arg Arg Gly Arg Ile Trp Lys Arg 
                245                 250                 255     


Trp Asn Glu Thr Ile Thr Gly Pro Ser Gly Cys Ala Asn Asn Thr Cys 
            260                 265                 270         


Tyr Asn Val Ser Val Ile Val Pro Asp Tyr Gln Cys Tyr Leu Asp Arg 
        275                 280                 285             


Val Asp Thr Trp Leu Gln Gly Lys Ile Asn Ile Ser Leu Cys Leu Thr 
    290                 295                 300                 


Gly Gly Lys Met Leu Tyr Asn Lys Val Thr Lys Gln Leu Ser Tyr Cys 
305                 310                 315                 320 


Thr Asp Pro Leu Gln Ile Pro Leu Ile Asn Tyr Thr Phe Gly Pro Asn 
                325                 330                 335     


Gln Thr Cys Met Trp Asn Thr Ser Gln Ile Gln Asp Pro Glu Ile Pro 
            340                 345                 350         


Lys Cys Gly Trp Trp Asn Gln Met Ala Tyr Tyr Asn Ser Cys Lys Trp 
        355                 360                 365             


Glu Glu Ala Lys Val Lys Phe His Cys Gln Arg Thr Gln Ser Gln Pro 
    370                 375                 380                 


Gly Ser Trp Phe Arg Ala Ile Ser Ser Trp Lys Gln Arg Asn Arg Trp 
385                 390                 395                 400 


Glu Trp Arg Pro Asp Phe Lys Ser Lys Lys Val Lys Ile Ser Leu Pro 
                405                 410                 415     


Cys Asn Ser Thr Lys Asn Leu Thr Phe Ala Met Arg Ser Ser Gly Asp 
            420                 425                 430         


Tyr Gly Glu Val Thr Gly Ala Trp Ile Glu Phe Gly Cys His Arg Asn 
        435                 440                 445             


Lys Ser Asn Leu His Thr Glu Ala Arg Phe Arg Ile Arg Cys Arg Trp 
    450                 455                 460                 


Asn Val Gly Ser Asp Thr Ser Leu Ile Asp Thr Cys Gly Asn Thr Pro 
465                 470                 475                 480 


Asn Val Ser Gly Ala Asn Pro Val Asp Cys Thr Met Tyr Ser Asn Lys 
                485                 490                 495     


Met Tyr Asn Cys Ser Leu Gln Asn Gly Phe Thr Met Lys Val Asp Asp 
            500                 505                 510         


Leu Ile Val His Phe Asn Met Thr Lys Ala Val Glu Met Tyr Asn Ile 
        515                 520                 525             


Ala Gly Asn Trp Ser Cys Thr Ser Asp Leu Pro Ser Ser Trp Gly Tyr 
    530                 535                 540                 


Met Asn Cys Asn Cys Thr Asn Ser Ser Ser Ser Tyr Ser Gly Thr Lys 
545                 550                 555                 560 


Met Ala Cys Pro Ser Asn Arg Gly Ile Leu Arg Asn Trp Tyr Asn Pro 
                565                 570                 575     


Val Ala Gly Leu Arg Gln Ser Leu Glu Gln Tyr Gln Val Val Lys Gln 
            580                 585                 590         


Pro Asp Tyr Leu Leu Val Pro Glu Glu Val Met Glu Tyr Lys Pro Arg 
        595                 600                 605             


Arg Lys Arg Ala Ala Ile His Val Met Leu Ala Leu Ala Thr Val Leu 
    610                 615                 620                 


Ser Ile Ala Gly Ala Gly Thr Gly Ala Thr Ala Ile Gly Met Val Thr 
625                 630                 635                 640 


Gln Tyr His Gln Val Leu Ala Thr His Gln Glu Ala Ile Glu Lys Val 
                645                 650                 655     


Thr Gly Ala Leu Lys Ile Asn Asn Leu Arg Leu Val Thr Leu Glu His 
            660                 665                 670         


Gln Val Leu Val Ile Gly Leu Lys Val Glu Ala Met Glu Arg Phe Leu 
        675                 680                 685             


Tyr Thr Ala Phe Ala Met Gln Glu Leu Gly Cys Asn Gln Asn Gln Phe 
    690                 695                 700                 


Phe Cys Lys Ile Pro Leu Glu Leu Trp Thr Arg Tyr Asn Met Thr Ile 
705                 710                 715                 720 


Asn Gln Thr Ile Trp Asn His Gly Asn Ile Thr Leu Gly Glu Trp Tyr 
                725                 730                 735     


Asn Gln Thr Lys Asp Leu Gln Gln Lys Phe Tyr Glu Ile Ile Met Asp 
            740                 745                 750         


Ile Glu Gln Asn Asn Val Gln Gly Lys Thr Gly Ile Gln Gln Leu Gln 
        755                 760                 765             


Lys Trp Glu Asp Trp Val Arg Trp Ile Gly Asn Ile Pro Gln Tyr Leu 
    770                 775                 780                 


Lys Gly Leu Leu Gly Gly Ile Leu Gly Ile Gly Leu Gly Val Leu Leu 
785                 790                 795                 800 


Leu Ile Leu Cys Leu Pro Thr Leu Val Asp Cys Ile Arg Asn Cys Ile 
                805                 810                 815     


His Lys Ile Leu Gly Tyr Thr Val Ile Ala Met Pro Glu Val Glu Gly 
            820                 825                 830         


Glu Glu Ile Gln Pro Gln Met Glu Leu Arg Arg Asn Gly Arg Gln Cys 
        835                 840                 845             


Gly Met Ser Glu Lys Glu Glu Glu 
    850                 855     


<210>  330
<211>  856
<212>  PRT
<213>  Artificial sequence

<220>
<223>  Mutated sequence

<400>  330

Met Ala Glu Gly Phe Ala Ala Asn Arg Gln Trp Ile Gly Pro Glu Glu 
1               5                   10                  15      


Ala Glu Glu Leu Leu Asp Phe Asp Ile Ala Thr Gln Met Ser Glu Glu 
            20                  25                  30          


Gly Pro Leu Asn Pro Gly Val Asn Pro Phe Arg Val Pro Gly Ile Thr 
        35                  40                  45              


Glu Lys Glu Lys Gln Asn Tyr Cys Asn Ile Leu Gln Pro Lys Leu Gln 
    50                  55                  60                  


Asp Leu Arg Asn Glu Ile Gln Glu Val Lys Leu Glu Glu Gly Asn Ala 
65                  70                  75                  80  


Gly Lys Phe Arg Arg Ala Arg Phe Leu Arg Tyr Ser Asp Glu Arg Val 
                85                  90                  95      


Leu Ser Leu Val His Ala Phe Ile Gly Tyr Cys Ile Tyr Leu Gly Asn 
            100                 105                 110         


Arg Asn Lys Leu Gly Ser Leu Arg His Asp Ile Asp Ile Glu Ala Pro 
        115                 120                 125             


Gln Glu Glu Cys Tyr Asn Asn Arg Glu Lys Gly Thr Thr Asp Asn Ile 
    130                 135                 140                 


Lys Tyr Gly Arg Arg Cys Cys Leu Gly Thr Val Thr Leu Tyr Leu Ile 
145                 150                 155                 160 


Leu Phe Thr Gly Val Ile Val Tyr Ser Gln Thr Ala Gly Ala Gln Val 
                165                 170                 175     


Val Trp Arg Leu Pro Pro Leu Val Val Pro Val Glu Glu Ser Glu Ile 
            180                 185                 190         


Ile Phe Trp Asp Cys Trp Ala Pro Glu Glu Pro Ala Cys Gln Asp Phe 
        195                 200                 205             


Leu Gly Ala Met Ile His Leu Lys Ala Lys Thr Asn Ile Ser Ile Arg 
    210                 215                 220                 


Glu Gly Pro Thr Leu Gly Asn Trp Ala Arg Glu Ile Trp Ala Thr Leu 
225                 230                 235                 240 


Phe Lys Lys Ala Thr Arg Gln Cys Arg Arg Gly Arg Ile Trp Lys Arg 
                245                 250                 255     


Trp Asn Glu Thr Ile Thr Gly Pro Ser Gly Cys Ala Asn Asn Thr Cys 
            260                 265                 270         


Tyr Asn Val Ser Val Ile Val Pro Asp Tyr Gln Cys Tyr Leu Asp Arg 
        275                 280                 285             


Val Asp Thr Trp Leu Gln Gly Lys Ile Asn Ile Ser Leu Cys Leu Thr 
    290                 295                 300                 


Gly Gly Lys Met Leu Tyr Asn Lys Val Thr Lys Gln Leu Ser Tyr Cys 
305                 310                 315                 320 


Thr Asp Pro Leu Gln Ile Pro Leu Ile Asn Tyr Thr Phe Gly Pro Asn 
                325                 330                 335     


Gln Thr Cys Met Trp Asn Thr Ser Gln Ile Gln Asp Pro Glu Ile Pro 
            340                 345                 350         


Lys Cys Gly Trp Trp Asn Gln Met Ala Tyr Tyr Asn Ser Cys Lys Trp 
        355                 360                 365             


Glu Glu Ala Lys Val Lys Phe His Cys Gln Arg Thr Gln Ser Gln Pro 
    370                 375                 380                 


Gly Ser Trp Phe Arg Ala Ile Ser Ser Trp Lys Gln Arg Asn Arg Trp 
385                 390                 395                 400 


Glu Trp Arg Pro Asp Phe Lys Ser Lys Lys Val Lys Ile Ser Leu Pro 
                405                 410                 415     


Cys Asn Ser Thr Lys Asn Leu Thr Phe Ala Met Arg Ser Ser Gly Asp 
            420                 425                 430         


Tyr Gly Glu Val Thr Gly Ala Trp Ile Glu Phe Gly Cys His Arg Asn 
        435                 440                 445             


Lys Ser Asn Leu His Thr Glu Ala Arg Phe Arg Ile Arg Cys Arg Trp 
    450                 455                 460                 


Asn Val Gly Ser Asp Thr Ser Leu Ile Asp Thr Cys Gly Asn Thr Pro 
465                 470                 475                 480 


Asn Val Ser Gly Ala Asn Pro Val Asp Cys Thr Met Tyr Ser Asn Lys 
                485                 490                 495     


Met Tyr Asn Cys Ser Leu Gln Asn Gly Phe Thr Met Lys Val Asp Asp 
            500                 505                 510         


Leu Ile Val His Phe Asn Met Thr Lys Ala Val Glu Met Tyr Asn Ile 
        515                 520                 525             


Ala Gly Asn Trp Ser Cys Thr Ser Asp Leu Pro Ser Ser Trp Gly Tyr 
    530                 535                 540                 


Met Asn Cys Asn Cys Thr Asn Ser Ser Ser Ser Tyr Ser Gly Thr Lys 
545                 550                 555                 560 


Met Ala Cys Pro Ser Asn Arg Gly Ile Leu Arg Asn Trp Tyr Asn Pro 
                565                 570                 575     


Val Ala Gly Leu Arg Gln Ser Leu Glu Gln Tyr Gln Val Val Lys Gln 
            580                 585                 590         


Pro Asp Tyr Leu Leu Val Pro Glu Glu Val Met Glu Tyr Lys Pro Arg 
        595                 600                 605             


Arg Lys Arg Ala Ala Ile His Val Met Leu Ala Leu Ala Thr Val Leu 
    610                 615                 620                 


Ser Ile Ala Gly Ala Gly Thr Gly Ala Thr Ala Ile Gly Met Val Thr 
625                 630                 635                 640 


Gln Tyr His Gln Val Leu Ala Thr His Gln Glu Ala Ile Glu Lys Val 
                645                 650                 655     


Thr Gly Ala Leu Lys Ile Asn Asn Leu Arg Leu Val Thr Leu Glu His 
            660                 665                 670         


Gln Val Leu Val Ile Gly Leu Lys Val Glu Ala Met Glu Gly Phe Leu 
        675                 680                 685             


Tyr Thr Ala Phe Ala Met Gln Glu Leu Gly Cys Asn Gln Asn Gln Phe 
    690                 695                 700                 


Phe Cys Lys Ile Pro Leu Glu Leu Trp Thr Arg Tyr Asn Met Thr Ile 
705                 710                 715                 720 


Asn Gln Thr Ile Trp Asn His Gly Asn Ile Thr Leu Gly Glu Trp Tyr 
                725                 730                 735     


Asn Gln Thr Lys Asp Leu Gln Gln Lys Phe Tyr Glu Ile Ile Met Asp 
            740                 745                 750         


Ile Glu Gln Asn Asn Val Gln Gly Lys Thr Gly Ile Gln Gln Leu Gln 
        755                 760                 765             


Lys Trp Glu Asp Trp Val Arg Trp Ile Gly Asn Ile Pro Gln Tyr Leu 
    770                 775                 780                 


Lys Gly Leu Leu Gly Gly Ile Leu Gly Ile Gly Leu Gly Val Leu Leu 
785                 790                 795                 800 


Leu Ile Leu Cys Leu Pro Thr Leu Val Asp Cys Ile Arg Asn Cys Ile 
                805                 810                 815     


His Lys Ile Leu Gly Tyr Thr Val Ile Ala Met Pro Glu Val Glu Gly 
            820                 825                 830         


Glu Glu Ile Gln Pro Gln Met Glu Leu Arg Arg Asn Gly Arg Gln Cys 
        835                 840                 845             


Gly Met Ser Glu Lys Glu Glu Glu 
    850                 855     


<210>  331
<211>  856
<212>  PRT
<213>  Artificial sequence

<220>
<223>  Mutated sequence

<400>  331

Met Ala Glu Gly Phe Ala Ala Asn Arg Gln Trp Ile Gly Pro Glu Glu 
1               5                   10                  15      


Ala Glu Glu Leu Leu Asp Phe Asp Ile Ala Thr Gln Met Ser Glu Glu 
            20                  25                  30          


Gly Pro Leu Asn Pro Gly Val Asn Pro Phe Arg Val Pro Gly Ile Thr 
        35                  40                  45              


Glu Lys Glu Lys Gln Asn Tyr Cys Asn Ile Leu Gln Pro Lys Leu Gln 
    50                  55                  60                  


Asp Leu Arg Asn Glu Ile Gln Glu Val Lys Leu Glu Glu Gly Asn Ala 
65                  70                  75                  80  


Gly Lys Phe Arg Arg Ala Arg Phe Leu Arg Tyr Ser Asp Glu Arg Val 
                85                  90                  95      


Leu Ser Leu Val His Ala Phe Ile Gly Tyr Cys Ile Tyr Leu Gly Asn 
            100                 105                 110         


Arg Asn Lys Leu Gly Ser Leu Arg His Asp Ile Asp Ile Glu Ala Pro 
        115                 120                 125             


Gln Glu Glu Cys Tyr Asn Asn Arg Glu Lys Gly Thr Thr Asp Asn Ile 
    130                 135                 140                 


Lys Tyr Gly Arg Arg Cys Cys Leu Gly Thr Val Thr Leu Tyr Leu Ile 
145                 150                 155                 160 


Leu Phe Thr Gly Val Ile Val Tyr Ser Gln Thr Ala Gly Ala Gln Val 
                165                 170                 175     


Val Trp Arg Leu Pro Pro Leu Val Val Pro Val Glu Glu Ser Glu Ile 
            180                 185                 190         


Ile Phe Trp Asp Cys Trp Ala Pro Glu Glu Pro Ala Cys Gln Asp Phe 
        195                 200                 205             


Leu Gly Ala Met Ile His Leu Lys Ala Lys Thr Asn Ile Ser Ile Arg 
    210                 215                 220                 


Glu Gly Pro Thr Leu Gly Asn Trp Ala Arg Glu Ile Trp Ala Thr Leu 
225                 230                 235                 240 


Phe Lys Lys Ala Thr Arg Gln Cys Arg Arg Gly Arg Ile Trp Lys Arg 
                245                 250                 255     


Trp Asn Glu Thr Ile Thr Gly Pro Ser Gly Cys Ala Asn Asn Thr Cys 
            260                 265                 270         


Tyr Asn Val Ser Val Ile Val Pro Asp Tyr Gln Cys Tyr Leu Asp Arg 
        275                 280                 285             


Val Asp Thr Trp Leu Gln Gly Lys Ile Asn Ile Ser Leu Cys Leu Thr 
    290                 295                 300                 


Gly Gly Lys Met Leu Tyr Asn Lys Val Thr Lys Gln Leu Ser Tyr Cys 
305                 310                 315                 320 


Thr Asp Pro Leu Gln Ile Pro Leu Ile Asn Tyr Thr Phe Gly Pro Asn 
                325                 330                 335     


Gln Thr Cys Met Trp Asn Thr Ser Gln Ile Gln Asp Pro Glu Ile Pro 
            340                 345                 350         


Lys Cys Gly Trp Trp Asn Gln Met Ala Tyr Tyr Asn Ser Cys Lys Trp 
        355                 360                 365             


Glu Glu Ala Lys Val Lys Phe His Cys Gln Arg Thr Gln Ser Gln Pro 
    370                 375                 380                 


Gly Ser Trp Phe Arg Ala Ile Ser Ser Trp Lys Gln Arg Asn Arg Trp 
385                 390                 395                 400 


Glu Trp Arg Pro Asp Phe Lys Ser Lys Lys Val Lys Ile Ser Leu Pro 
                405                 410                 415     


Cys Asn Ser Thr Lys Asn Leu Thr Phe Ala Met Arg Ser Ser Gly Asp 
            420                 425                 430         


Tyr Gly Glu Val Thr Gly Ala Trp Ile Glu Phe Gly Cys His Arg Asn 
        435                 440                 445             


Lys Ser Asn Leu His Thr Glu Ala Arg Phe Arg Ile Arg Cys Arg Trp 
    450                 455                 460                 


Asn Val Gly Ser Asp Thr Ser Leu Ile Asp Thr Cys Gly Asn Thr Pro 
465                 470                 475                 480 


Asn Val Ser Gly Ala Asn Pro Val Asp Cys Thr Met Tyr Ser Asn Lys 
                485                 490                 495     


Met Tyr Asn Cys Ser Leu Gln Asn Gly Phe Thr Met Lys Val Asp Asp 
            500                 505                 510         


Leu Ile Val His Phe Asn Met Thr Lys Ala Val Glu Met Tyr Asn Ile 
        515                 520                 525             


Ala Gly Asn Trp Ser Cys Thr Ser Asp Leu Pro Ser Ser Trp Gly Tyr 
    530                 535                 540                 


Met Asn Cys Asn Cys Thr Asn Ser Ser Ser Ser Tyr Ser Gly Thr Lys 
545                 550                 555                 560 


Met Ala Cys Pro Ser Asn Arg Gly Ile Leu Arg Asn Trp Tyr Asn Pro 
                565                 570                 575     


Val Ala Gly Leu Arg Gln Ser Leu Glu Gln Tyr Gln Val Val Lys Gln 
            580                 585                 590         


Pro Asp Tyr Leu Leu Val Pro Glu Glu Val Met Glu Tyr Lys Pro Arg 
        595                 600                 605             


Arg Lys Arg Ala Ala Ile His Val Met Leu Ala Leu Ala Thr Val Leu 
    610                 615                 620                 


Ser Ile Ala Gly Ala Gly Thr Gly Ala Thr Ala Ile Gly Met Val Thr 
625                 630                 635                 640 


Gln Tyr His Gln Val Leu Ala Thr His Gln Glu Ala Ile Glu Lys Val 
                645                 650                 655     


Thr Gly Ala Leu Lys Ile Asn Asn Leu Arg Leu Val Thr Leu Glu His 
            660                 665                 670         


Gln Val Leu Val Ile Gly Leu Lys Val Glu Ala Met Glu Leu Phe Leu 
        675                 680                 685             


Tyr Thr Ala Phe Ala Met Gln Glu Leu Gly Cys Asn Gln Asn Gln Phe 
    690                 695                 700                 


Phe Cys Lys Ile Pro Leu Glu Leu Trp Thr Arg Tyr Asn Met Thr Ile 
705                 710                 715                 720 


Asn Gln Thr Ile Trp Asn His Gly Asn Ile Thr Leu Gly Glu Trp Tyr 
                725                 730                 735     


Asn Gln Thr Lys Asp Leu Gln Gln Lys Phe Tyr Glu Ile Ile Met Asp 
            740                 745                 750         


Ile Glu Gln Asn Asn Val Gln Gly Lys Thr Gly Ile Gln Gln Leu Gln 
        755                 760                 765             


Lys Trp Glu Asp Trp Val Arg Trp Ile Gly Asn Ile Pro Gln Tyr Leu 
    770                 775                 780                 


Lys Gly Leu Leu Gly Gly Ile Leu Gly Ile Gly Leu Gly Val Leu Leu 
785                 790                 795                 800 


Leu Ile Leu Cys Leu Pro Thr Leu Val Asp Cys Ile Arg Asn Cys Ile 
                805                 810                 815     


His Lys Ile Leu Gly Tyr Thr Val Ile Ala Met Pro Glu Val Glu Gly 
            820                 825                 830         


Glu Glu Ile Gln Pro Gln Met Glu Leu Arg Arg Asn Gly Arg Gln Cys 
        835                 840                 845             


Gly Met Ser Glu Lys Glu Glu Glu 
    850                 855     


<210>  332
<211>  856
<212>  PRT
<213>  Artificial sequence

<220>
<223>  Mutated sequence

<400>  332

Met Ala Glu Gly Phe Ala Ala Asn Arg Gln Trp Ile Gly Pro Glu Glu 
1               5                   10                  15      


Ala Glu Glu Leu Leu Asp Phe Asp Ile Ala Thr Gln Met Ser Glu Glu 
            20                  25                  30          


Gly Pro Leu Asn Pro Gly Val Asn Pro Phe Arg Val Pro Gly Ile Thr 
        35                  40                  45              


Glu Lys Glu Lys Gln Asn Tyr Cys Asn Ile Leu Gln Pro Lys Leu Gln 
    50                  55                  60                  


Asp Leu Arg Asn Glu Ile Gln Glu Val Lys Leu Glu Glu Gly Asn Ala 
65                  70                  75                  80  


Gly Lys Phe Arg Arg Ala Arg Phe Leu Arg Tyr Ser Asp Glu Arg Val 
                85                  90                  95      


Leu Ser Leu Val His Ala Phe Ile Gly Tyr Cys Ile Tyr Leu Gly Asn 
            100                 105                 110         


Arg Asn Lys Leu Gly Ser Leu Arg His Asp Ile Asp Ile Glu Ala Pro 
        115                 120                 125             


Gln Glu Glu Cys Tyr Asn Asn Arg Glu Lys Gly Thr Thr Asp Asn Ile 
    130                 135                 140                 


Lys Tyr Gly Arg Arg Cys Cys Leu Gly Thr Val Thr Leu Tyr Leu Ile 
145                 150                 155                 160 


Leu Phe Thr Gly Val Ile Val Tyr Ser Gln Thr Ala Gly Ala Gln Val 
                165                 170                 175     


Val Trp Arg Leu Pro Pro Leu Val Val Pro Val Glu Glu Ser Glu Ile 
            180                 185                 190         


Ile Phe Trp Asp Cys Trp Ala Pro Glu Glu Pro Ala Cys Gln Asp Phe 
        195                 200                 205             


Leu Gly Ala Met Ile His Leu Lys Ala Lys Thr Asn Ile Ser Ile Arg 
    210                 215                 220                 


Glu Gly Pro Thr Leu Gly Asn Trp Ala Arg Glu Ile Trp Ala Thr Leu 
225                 230                 235                 240 


Phe Lys Lys Ala Thr Arg Gln Cys Arg Arg Gly Arg Ile Trp Lys Arg 
                245                 250                 255     


Trp Asn Glu Thr Ile Thr Gly Pro Ser Gly Cys Ala Asn Asn Thr Cys 
            260                 265                 270         


Tyr Asn Val Ser Val Ile Val Pro Asp Tyr Gln Cys Tyr Leu Asp Arg 
        275                 280                 285             


Val Asp Thr Trp Leu Gln Gly Lys Ile Asn Ile Ser Leu Cys Leu Thr 
    290                 295                 300                 


Gly Gly Lys Met Leu Tyr Asn Lys Val Thr Lys Gln Leu Ser Tyr Cys 
305                 310                 315                 320 


Thr Asp Pro Leu Gln Ile Pro Leu Ile Asn Tyr Thr Phe Gly Pro Asn 
                325                 330                 335     


Gln Thr Cys Met Trp Asn Thr Ser Gln Ile Gln Asp Pro Glu Ile Pro 
            340                 345                 350         


Lys Cys Gly Trp Trp Asn Gln Met Ala Tyr Tyr Asn Ser Cys Lys Trp 
        355                 360                 365             


Glu Glu Ala Lys Val Lys Phe His Cys Gln Arg Thr Gln Ser Gln Pro 
    370                 375                 380                 


Gly Ser Trp Phe Arg Ala Ile Ser Ser Trp Lys Gln Arg Asn Arg Trp 
385                 390                 395                 400 


Glu Trp Arg Pro Asp Phe Lys Ser Lys Lys Val Lys Ile Ser Leu Pro 
                405                 410                 415     


Cys Asn Ser Thr Lys Asn Leu Thr Phe Ala Met Arg Ser Ser Gly Asp 
            420                 425                 430         


Tyr Gly Glu Val Thr Gly Ala Trp Ile Glu Phe Gly Cys His Arg Asn 
        435                 440                 445             


Lys Ser Asn Leu His Thr Glu Ala Arg Phe Arg Ile Arg Cys Arg Trp 
    450                 455                 460                 


Asn Val Gly Ser Asp Thr Ser Leu Ile Asp Thr Cys Gly Asn Thr Pro 
465                 470                 475                 480 


Asn Val Ser Gly Ala Asn Pro Val Asp Cys Thr Met Tyr Ser Asn Lys 
                485                 490                 495     


Met Tyr Asn Cys Ser Leu Gln Asn Gly Phe Thr Met Lys Val Asp Asp 
            500                 505                 510         


Leu Ile Val His Phe Asn Met Thr Lys Ala Val Glu Met Tyr Asn Ile 
        515                 520                 525             


Ala Gly Asn Trp Ser Cys Thr Ser Asp Leu Pro Ser Ser Trp Gly Tyr 
    530                 535                 540                 


Met Asn Cys Asn Cys Thr Asn Ser Ser Ser Ser Tyr Ser Gly Thr Lys 
545                 550                 555                 560 


Met Ala Cys Pro Ser Asn Arg Gly Ile Leu Arg Asn Trp Tyr Asn Pro 
                565                 570                 575     


Val Ala Gly Leu Arg Gln Ser Leu Glu Gln Tyr Gln Val Val Lys Gln 
            580                 585                 590         


Pro Asp Tyr Leu Leu Val Pro Glu Glu Val Met Glu Tyr Lys Pro Arg 
        595                 600                 605             


Arg Lys Arg Ala Ala Ile His Val Met Leu Ala Leu Ala Thr Val Leu 
    610                 615                 620                 


Ser Ile Ala Gly Ala Gly Thr Gly Ala Thr Ala Ile Gly Met Val Thr 
625                 630                 635                 640 


Gln Tyr His Gln Val Leu Ala Thr His Gln Glu Ala Ile Glu Lys Val 
                645                 650                 655     


Thr Gly Ala Leu Lys Ile Asn Asn Leu Arg Leu Val Thr Leu Glu His 
            660                 665                 670         


Gln Val Leu Val Ile Gly Leu Lys Val Glu Ala Met Glu Ala Phe Leu 
        675                 680                 685             


Tyr Thr Ala Phe Ala Met Gln Glu Leu Gly Cys Asn Gln Asn Gln Phe 
    690                 695                 700                 


Phe Cys Lys Ile Pro Leu Glu Leu Trp Thr Arg Tyr Asn Met Thr Ile 
705                 710                 715                 720 


Asn Gln Thr Ile Trp Asn His Gly Asn Ile Thr Leu Gly Glu Trp Tyr 
                725                 730                 735     


Asn Gln Thr Lys Asp Leu Gln Gln Lys Phe Tyr Glu Ile Ile Met Asp 
            740                 745                 750         


Ile Glu Gln Asn Asn Val Gln Gly Lys Thr Gly Ile Gln Gln Leu Gln 
        755                 760                 765             


Lys Trp Glu Asp Trp Val Arg Trp Ile Gly Asn Ile Pro Gln Tyr Leu 
    770                 775                 780                 


Lys Gly Leu Leu Gly Gly Ile Leu Gly Ile Gly Leu Gly Val Leu Leu 
785                 790                 795                 800 


Leu Ile Leu Cys Leu Pro Thr Leu Val Asp Cys Ile Arg Asn Cys Ile 
                805                 810                 815     


His Lys Ile Leu Gly Tyr Thr Val Ile Ala Met Pro Glu Val Glu Gly 
            820                 825                 830         


Glu Glu Ile Gln Pro Gln Met Glu Leu Arg Arg Asn Gly Arg Gln Cys 
        835                 840                 845             


Gly Met Ser Glu Lys Glu Glu Glu 
    850                 855     


<210>  333
<211>  856
<212>  PRT
<213>  Artificial sequence

<220>
<223>  Mutated sequence

<400>  333

Met Ala Glu Gly Phe Ala Ala Asn Arg Gln Trp Ile Gly Pro Glu Glu 
1               5                   10                  15      


Ala Glu Glu Leu Leu Asp Phe Asp Ile Ala Thr Gln Met Ser Glu Glu 
            20                  25                  30          


Gly Pro Leu Asn Pro Gly Val Asn Pro Phe Arg Val Pro Gly Ile Thr 
        35                  40                  45              


Glu Lys Glu Lys Gln Asn Tyr Cys Asn Ile Leu Gln Pro Lys Leu Gln 
    50                  55                  60                  


Asp Leu Arg Asn Glu Ile Gln Glu Val Lys Leu Glu Glu Gly Asn Ala 
65                  70                  75                  80  


Gly Lys Phe Arg Arg Ala Arg Phe Leu Arg Tyr Ser Asp Glu Arg Val 
                85                  90                  95      


Leu Ser Leu Val His Ala Phe Ile Gly Tyr Cys Ile Tyr Leu Gly Asn 
            100                 105                 110         


Arg Asn Lys Leu Gly Ser Leu Arg His Asp Ile Asp Ile Glu Ala Pro 
        115                 120                 125             


Gln Glu Glu Cys Tyr Asn Asn Arg Glu Lys Gly Thr Thr Asp Asn Ile 
    130                 135                 140                 


Lys Tyr Gly Arg Arg Cys Cys Leu Gly Thr Val Thr Leu Tyr Leu Ile 
145                 150                 155                 160 


Leu Phe Thr Gly Val Ile Val Tyr Ser Gln Thr Ala Gly Ala Gln Val 
                165                 170                 175     


Val Trp Arg Leu Pro Pro Leu Val Val Pro Val Glu Glu Ser Glu Ile 
            180                 185                 190         


Ile Phe Trp Asp Cys Trp Ala Pro Glu Glu Pro Ala Cys Gln Asp Phe 
        195                 200                 205             


Leu Gly Ala Met Ile His Leu Lys Ala Lys Thr Asn Ile Ser Ile Arg 
    210                 215                 220                 


Glu Gly Pro Thr Leu Gly Asn Trp Ala Arg Glu Ile Trp Ala Thr Leu 
225                 230                 235                 240 


Phe Lys Lys Ala Thr Arg Gln Cys Arg Arg Gly Arg Ile Trp Lys Arg 
                245                 250                 255     


Trp Asn Glu Thr Ile Thr Gly Pro Ser Gly Cys Ala Asn Asn Thr Cys 
            260                 265                 270         


Tyr Asn Val Ser Val Ile Val Pro Asp Tyr Gln Cys Tyr Leu Asp Arg 
        275                 280                 285             


Val Asp Thr Trp Leu Gln Gly Lys Ile Asn Ile Ser Leu Cys Leu Thr 
    290                 295                 300                 


Gly Gly Lys Met Leu Tyr Asn Lys Val Thr Lys Gln Leu Ser Tyr Cys 
305                 310                 315                 320 


Thr Asp Pro Leu Gln Ile Pro Leu Ile Asn Tyr Thr Phe Gly Pro Asn 
                325                 330                 335     


Gln Thr Cys Met Trp Asn Thr Ser Gln Ile Gln Asp Pro Glu Ile Pro 
            340                 345                 350         


Lys Cys Gly Trp Trp Asn Gln Met Ala Tyr Tyr Asn Ser Cys Lys Trp 
        355                 360                 365             


Glu Glu Ala Lys Val Lys Phe His Cys Gln Arg Thr Gln Ser Gln Pro 
    370                 375                 380                 


Gly Ser Trp Phe Arg Ala Ile Ser Ser Trp Lys Gln Arg Asn Arg Trp 
385                 390                 395                 400 


Glu Trp Arg Pro Asp Phe Lys Ser Lys Lys Val Lys Ile Ser Leu Pro 
                405                 410                 415     


Cys Asn Ser Thr Lys Asn Leu Thr Phe Ala Met Arg Ser Ser Gly Asp 
            420                 425                 430         


Tyr Gly Glu Val Thr Gly Ala Trp Ile Glu Phe Gly Cys His Arg Asn 
        435                 440                 445             


Lys Ser Asn Leu His Thr Glu Ala Arg Phe Arg Ile Arg Cys Arg Trp 
    450                 455                 460                 


Asn Val Gly Ser Asp Thr Ser Leu Ile Asp Thr Cys Gly Asn Thr Pro 
465                 470                 475                 480 


Asn Val Ser Gly Ala Asn Pro Val Asp Cys Thr Met Tyr Ser Asn Lys 
                485                 490                 495     


Met Tyr Asn Cys Ser Leu Gln Asn Gly Phe Thr Met Lys Val Asp Asp 
            500                 505                 510         


Leu Ile Val His Phe Asn Met Thr Lys Ala Val Glu Met Tyr Asn Ile 
        515                 520                 525             


Ala Gly Asn Trp Ser Cys Thr Ser Asp Leu Pro Ser Ser Trp Gly Tyr 
    530                 535                 540                 


Met Asn Cys Asn Cys Thr Asn Ser Ser Ser Ser Tyr Ser Gly Thr Lys 
545                 550                 555                 560 


Met Ala Cys Pro Ser Asn Arg Gly Ile Leu Arg Asn Trp Tyr Asn Pro 
                565                 570                 575     


Val Ala Gly Leu Arg Gln Ser Leu Glu Gln Tyr Gln Val Val Lys Gln 
            580                 585                 590         


Pro Asp Tyr Leu Leu Val Pro Glu Glu Val Met Glu Tyr Lys Pro Arg 
        595                 600                 605             


Arg Lys Arg Ala Ala Ile His Val Met Leu Ala Leu Ala Thr Val Leu 
    610                 615                 620                 


Ser Ile Ala Gly Ala Gly Thr Gly Ala Thr Ala Ile Gly Met Val Thr 
625                 630                 635                 640 


Gln Tyr His Gln Val Leu Ala Thr His Gln Glu Ala Ile Glu Lys Val 
                645                 650                 655     


Thr Gly Ala Leu Lys Ile Asn Asn Leu Arg Leu Val Thr Leu Glu His 
            660                 665                 670         


Gln Val Leu Val Ile Gly Leu Lys Val Glu Ala Met Glu Phe Phe Leu 
        675                 680                 685             


Tyr Thr Ala Phe Ala Met Gln Glu Leu Gly Cys Asn Gln Asn Gln Phe 
    690                 695                 700                 


Phe Cys Lys Ile Pro Leu Glu Leu Trp Thr Arg Tyr Asn Met Thr Ile 
705                 710                 715                 720 


Asn Gln Thr Ile Trp Asn His Gly Asn Ile Thr Leu Gly Glu Trp Tyr 
                725                 730                 735     


Asn Gln Thr Lys Asp Leu Gln Gln Lys Phe Tyr Glu Ile Ile Met Asp 
            740                 745                 750         


Ile Glu Gln Asn Asn Val Gln Gly Lys Thr Gly Ile Gln Gln Leu Gln 
        755                 760                 765             


Lys Trp Glu Asp Trp Val Arg Trp Ile Gly Asn Ile Pro Gln Tyr Leu 
    770                 775                 780                 


Lys Gly Leu Leu Gly Gly Ile Leu Gly Ile Gly Leu Gly Val Leu Leu 
785                 790                 795                 800 


Leu Ile Leu Cys Leu Pro Thr Leu Val Asp Cys Ile Arg Asn Cys Ile 
                805                 810                 815     


His Lys Ile Leu Gly Tyr Thr Val Ile Ala Met Pro Glu Val Glu Gly 
            820                 825                 830         


Glu Glu Ile Gln Pro Gln Met Glu Leu Arg Arg Asn Gly Arg Gln Cys 
        835                 840                 845             


Gly Met Ser Glu Lys Glu Glu Glu 
    850                 855     


<210>  334
<211>  856
<212>  PRT
<213>  Artificial sequence

<220>
<223>  Mutated sequence

<400>  334

Met Ala Glu Gly Phe Ala Ala Asn Arg Gln Trp Ile Gly Pro Glu Glu 
1               5                   10                  15      


Ala Glu Glu Leu Leu Asp Phe Asp Ile Ala Thr Gln Met Ser Glu Glu 
            20                  25                  30          


Gly Pro Leu Asn Pro Gly Val Asn Pro Phe Arg Val Pro Gly Ile Thr 
        35                  40                  45              


Glu Lys Glu Lys Gln Asn Tyr Cys Asn Ile Leu Gln Pro Lys Leu Gln 
    50                  55                  60                  


Asp Leu Arg Asn Glu Ile Gln Glu Val Lys Leu Glu Glu Gly Asn Ala 
65                  70                  75                  80  


Gly Lys Phe Arg Arg Ala Arg Phe Leu Arg Tyr Ser Asp Glu Arg Val 
                85                  90                  95      


Leu Ser Leu Val His Ala Phe Ile Gly Tyr Cys Ile Tyr Leu Gly Asn 
            100                 105                 110         


Arg Asn Lys Leu Gly Ser Leu Arg His Asp Ile Asp Ile Glu Ala Pro 
        115                 120                 125             


Gln Glu Glu Cys Tyr Asn Asn Arg Glu Lys Gly Thr Thr Asp Asn Ile 
    130                 135                 140                 


Lys Tyr Gly Arg Arg Cys Cys Leu Gly Thr Val Thr Leu Tyr Leu Ile 
145                 150                 155                 160 


Leu Phe Thr Gly Val Ile Val Tyr Ser Gln Thr Ala Gly Ala Gln Val 
                165                 170                 175     


Val Trp Arg Leu Pro Pro Leu Val Val Pro Val Glu Glu Ser Glu Ile 
            180                 185                 190         


Ile Phe Trp Asp Cys Trp Ala Pro Glu Glu Pro Ala Cys Gln Asp Phe 
        195                 200                 205             


Leu Gly Ala Met Ile His Leu Lys Ala Lys Thr Asn Ile Ser Ile Arg 
    210                 215                 220                 


Glu Gly Pro Thr Leu Gly Asn Trp Ala Arg Glu Ile Trp Ala Thr Leu 
225                 230                 235                 240 


Phe Lys Lys Ala Thr Arg Gln Cys Arg Arg Gly Arg Ile Trp Lys Arg 
                245                 250                 255     


Trp Asn Glu Thr Ile Thr Gly Pro Ser Gly Cys Ala Asn Asn Thr Cys 
            260                 265                 270         


Tyr Asn Val Ser Val Ile Val Pro Asp Tyr Gln Cys Tyr Leu Asp Arg 
        275                 280                 285             


Val Asp Thr Trp Leu Gln Gly Lys Ile Asn Ile Ser Leu Cys Leu Thr 
    290                 295                 300                 


Gly Gly Lys Met Leu Tyr Asn Lys Val Thr Lys Gln Leu Ser Tyr Cys 
305                 310                 315                 320 


Thr Asp Pro Leu Gln Ile Pro Leu Ile Asn Tyr Thr Phe Gly Pro Asn 
                325                 330                 335     


Gln Thr Cys Met Trp Asn Thr Ser Gln Ile Gln Asp Pro Glu Ile Pro 
            340                 345                 350         


Lys Cys Gly Trp Trp Asn Gln Met Ala Tyr Tyr Asn Ser Cys Lys Trp 
        355                 360                 365             


Glu Glu Ala Lys Val Lys Phe His Cys Gln Arg Thr Gln Ser Gln Pro 
    370                 375                 380                 


Gly Ser Trp Phe Arg Ala Ile Ser Ser Trp Lys Gln Arg Asn Arg Trp 
385                 390                 395                 400 


Glu Trp Arg Pro Asp Phe Lys Ser Lys Lys Val Lys Ile Ser Leu Pro 
                405                 410                 415     


Cys Asn Ser Thr Lys Asn Leu Thr Phe Ala Met Arg Ser Ser Gly Asp 
            420                 425                 430         


Tyr Gly Glu Val Thr Gly Ala Trp Ile Glu Phe Gly Cys His Arg Asn 
        435                 440                 445             


Lys Ser Asn Leu His Thr Glu Ala Arg Phe Arg Ile Arg Cys Arg Trp 
    450                 455                 460                 


Asn Val Gly Ser Asp Thr Ser Leu Ile Asp Thr Cys Gly Asn Thr Pro 
465                 470                 475                 480 


Asn Val Ser Gly Ala Asn Pro Val Asp Cys Thr Met Tyr Ser Asn Lys 
                485                 490                 495     


Met Tyr Asn Cys Ser Leu Gln Asn Gly Phe Thr Met Lys Val Asp Asp 
            500                 505                 510         


Leu Ile Val His Phe Asn Met Thr Lys Ala Val Glu Met Tyr Asn Ile 
        515                 520                 525             


Ala Gly Asn Trp Ser Cys Thr Ser Asp Leu Pro Ser Ser Trp Gly Tyr 
    530                 535                 540                 


Met Asn Cys Asn Cys Thr Asn Ser Ser Ser Ser Tyr Ser Gly Thr Lys 
545                 550                 555                 560 


Met Ala Cys Pro Ser Asn Arg Gly Ile Leu Arg Asn Trp Tyr Asn Pro 
                565                 570                 575     


Val Ala Gly Leu Arg Gln Ser Leu Glu Gln Tyr Gln Val Val Lys Gln 
            580                 585                 590         


Pro Asp Tyr Leu Leu Val Pro Glu Glu Val Met Glu Tyr Lys Pro Arg 
        595                 600                 605             


Arg Lys Arg Ala Ala Ile His Val Met Leu Ala Leu Ala Thr Val Leu 
    610                 615                 620                 


Ser Ile Ala Gly Ala Gly Thr Gly Ala Thr Ala Ile Gly Met Val Thr 
625                 630                 635                 640 


Gln Tyr His Gln Val Leu Ala Thr His Gln Glu Ala Ile Glu Lys Val 
                645                 650                 655     


Thr Gly Ala Leu Lys Ile Asn Asn Leu Arg Leu Val Thr Leu Glu His 
            660                 665                 670         


Gln Val Leu Val Ile Gly Leu Lys Val Glu Ala Met Glu Lys Phe Leu 
        675                 680                 685             


Arg Thr Ala Phe Ala Met Gln Glu Leu Gly Cys Asn Gln Asn Gln Phe 
    690                 695                 700                 


Phe Cys Lys Ile Pro Leu Glu Leu Trp Thr Arg Tyr Asn Met Thr Ile 
705                 710                 715                 720 


Asn Gln Thr Ile Trp Asn His Gly Asn Ile Thr Leu Gly Glu Trp Tyr 
                725                 730                 735     


Asn Gln Thr Lys Asp Leu Gln Gln Lys Phe Tyr Glu Ile Ile Met Asp 
            740                 745                 750         


Ile Glu Gln Asn Asn Val Gln Gly Lys Thr Gly Ile Gln Gln Leu Gln 
        755                 760                 765             


Lys Trp Glu Asp Trp Val Arg Trp Ile Gly Asn Ile Pro Gln Tyr Leu 
    770                 775                 780                 


Lys Gly Leu Leu Gly Gly Ile Leu Gly Ile Gly Leu Gly Val Leu Leu 
785                 790                 795                 800 


Leu Ile Leu Cys Leu Pro Thr Leu Val Asp Cys Ile Arg Asn Cys Ile 
                805                 810                 815     


His Lys Ile Leu Gly Tyr Thr Val Ile Ala Met Pro Glu Val Glu Gly 
            820                 825                 830         


Glu Glu Ile Gln Pro Gln Met Glu Leu Arg Arg Asn Gly Arg Gln Cys 
        835                 840                 845             


Gly Met Ser Glu Lys Glu Glu Glu 
    850                 855     


<210>  335
<211>  856
<212>  PRT
<213>  Artificial sequence

<220>
<223>  Mutated sequence

<400>  335

Met Ala Glu Gly Phe Ala Ala Asn Arg Gln Trp Ile Gly Pro Glu Glu 
1               5                   10                  15      


Ala Glu Glu Leu Leu Asp Phe Asp Ile Ala Thr Gln Met Ser Glu Glu 
            20                  25                  30          


Gly Pro Leu Asn Pro Gly Val Asn Pro Phe Arg Val Pro Gly Ile Thr 
        35                  40                  45              


Glu Lys Glu Lys Gln Asn Tyr Cys Asn Ile Leu Gln Pro Lys Leu Gln 
    50                  55                  60                  


Asp Leu Arg Asn Glu Ile Gln Glu Val Lys Leu Glu Glu Gly Asn Ala 
65                  70                  75                  80  


Gly Lys Phe Arg Arg Ala Arg Phe Leu Arg Tyr Ser Asp Glu Arg Val 
                85                  90                  95      


Leu Ser Leu Val His Ala Phe Ile Gly Tyr Cys Ile Tyr Leu Gly Asn 
            100                 105                 110         


Arg Asn Lys Leu Gly Ser Leu Arg His Asp Ile Asp Ile Glu Ala Pro 
        115                 120                 125             


Gln Glu Glu Cys Tyr Asn Asn Arg Glu Lys Gly Thr Thr Asp Asn Ile 
    130                 135                 140                 


Lys Tyr Gly Arg Arg Cys Cys Leu Gly Thr Val Thr Leu Tyr Leu Ile 
145                 150                 155                 160 


Leu Phe Thr Gly Val Ile Val Tyr Ser Gln Thr Ala Gly Ala Gln Val 
                165                 170                 175     


Val Trp Arg Leu Pro Pro Leu Val Val Pro Val Glu Glu Ser Glu Ile 
            180                 185                 190         


Ile Phe Trp Asp Cys Trp Ala Pro Glu Glu Pro Ala Cys Gln Asp Phe 
        195                 200                 205             


Leu Gly Ala Met Ile His Leu Lys Ala Lys Thr Asn Ile Ser Ile Arg 
    210                 215                 220                 


Glu Gly Pro Thr Leu Gly Asn Trp Ala Arg Glu Ile Trp Ala Thr Leu 
225                 230                 235                 240 


Phe Lys Lys Ala Thr Arg Gln Cys Arg Arg Gly Arg Ile Trp Lys Arg 
                245                 250                 255     


Trp Asn Glu Thr Ile Thr Gly Pro Ser Gly Cys Ala Asn Asn Thr Cys 
            260                 265                 270         


Tyr Asn Val Ser Val Ile Val Pro Asp Tyr Gln Cys Tyr Leu Asp Arg 
        275                 280                 285             


Val Asp Thr Trp Leu Gln Gly Lys Ile Asn Ile Ser Leu Cys Leu Thr 
    290                 295                 300                 


Gly Gly Lys Met Leu Tyr Asn Lys Val Thr Lys Gln Leu Ser Tyr Cys 
305                 310                 315                 320 


Thr Asp Pro Leu Gln Ile Pro Leu Ile Asn Tyr Thr Phe Gly Pro Asn 
                325                 330                 335     


Gln Thr Cys Met Trp Asn Thr Ser Gln Ile Gln Asp Pro Glu Ile Pro 
            340                 345                 350         


Lys Cys Gly Trp Trp Asn Gln Met Ala Tyr Tyr Asn Ser Cys Lys Trp 
        355                 360                 365             


Glu Glu Ala Lys Val Lys Phe His Cys Gln Arg Thr Gln Ser Gln Pro 
    370                 375                 380                 


Gly Ser Trp Phe Arg Ala Ile Ser Ser Trp Lys Gln Arg Asn Arg Trp 
385                 390                 395                 400 


Glu Trp Arg Pro Asp Phe Lys Ser Lys Lys Val Lys Ile Ser Leu Pro 
                405                 410                 415     


Cys Asn Ser Thr Lys Asn Leu Thr Phe Ala Met Arg Ser Ser Gly Asp 
            420                 425                 430         


Tyr Gly Glu Val Thr Gly Ala Trp Ile Glu Phe Gly Cys His Arg Asn 
        435                 440                 445             


Lys Ser Asn Leu His Thr Glu Ala Arg Phe Arg Ile Arg Cys Arg Trp 
    450                 455                 460                 


Asn Val Gly Ser Asp Thr Ser Leu Ile Asp Thr Cys Gly Asn Thr Pro 
465                 470                 475                 480 


Asn Val Ser Gly Ala Asn Pro Val Asp Cys Thr Met Tyr Ser Asn Lys 
                485                 490                 495     


Met Tyr Asn Cys Ser Leu Gln Asn Gly Phe Thr Met Lys Val Asp Asp 
            500                 505                 510         


Leu Ile Val His Phe Asn Met Thr Lys Ala Val Glu Met Tyr Asn Ile 
        515                 520                 525             


Ala Gly Asn Trp Ser Cys Thr Ser Asp Leu Pro Ser Ser Trp Gly Tyr 
    530                 535                 540                 


Met Asn Cys Asn Cys Thr Asn Ser Ser Ser Ser Tyr Ser Gly Thr Lys 
545                 550                 555                 560 


Met Ala Cys Pro Ser Asn Arg Gly Ile Leu Arg Asn Trp Tyr Asn Pro 
                565                 570                 575     


Val Ala Gly Leu Arg Gln Ser Leu Glu Gln Tyr Gln Val Val Lys Gln 
            580                 585                 590         


Pro Asp Tyr Leu Leu Val Pro Glu Glu Val Met Glu Tyr Lys Pro Arg 
        595                 600                 605             


Arg Lys Arg Ala Ala Ile His Val Met Leu Ala Leu Ala Thr Val Leu 
    610                 615                 620                 


Ser Ile Ala Gly Ala Gly Thr Gly Ala Thr Ala Ile Gly Met Val Thr 
625                 630                 635                 640 


Gln Tyr His Gln Val Leu Ala Thr His Gln Glu Ala Ile Glu Lys Val 
                645                 650                 655     


Thr Gly Ala Leu Lys Ile Asn Asn Leu Arg Leu Val Thr Leu Glu His 
            660                 665                 670         


Gln Val Leu Val Ile Gly Leu Lys Val Glu Ala Met Glu Lys Phe Leu 
        675                 680                 685             


Gly Thr Ala Phe Ala Met Gln Glu Leu Gly Cys Asn Gln Asn Gln Phe 
    690                 695                 700                 


Phe Cys Lys Ile Pro Leu Glu Leu Trp Thr Arg Tyr Asn Met Thr Ile 
705                 710                 715                 720 


Asn Gln Thr Ile Trp Asn His Gly Asn Ile Thr Leu Gly Glu Trp Tyr 
                725                 730                 735     


Asn Gln Thr Lys Asp Leu Gln Gln Lys Phe Tyr Glu Ile Ile Met Asp 
            740                 745                 750         


Ile Glu Gln Asn Asn Val Gln Gly Lys Thr Gly Ile Gln Gln Leu Gln 
        755                 760                 765             


Lys Trp Glu Asp Trp Val Arg Trp Ile Gly Asn Ile Pro Gln Tyr Leu 
    770                 775                 780                 


Lys Gly Leu Leu Gly Gly Ile Leu Gly Ile Gly Leu Gly Val Leu Leu 
785                 790                 795                 800 


Leu Ile Leu Cys Leu Pro Thr Leu Val Asp Cys Ile Arg Asn Cys Ile 
                805                 810                 815     


His Lys Ile Leu Gly Tyr Thr Val Ile Ala Met Pro Glu Val Glu Gly 
            820                 825                 830         


Glu Glu Ile Gln Pro Gln Met Glu Leu Arg Arg Asn Gly Arg Gln Cys 
        835                 840                 845             


Gly Met Ser Glu Lys Glu Glu Glu 
    850                 855     


<210>  336
<211>  856
<212>  PRT
<213>  Artificial sequence

<220>
<223>  Mutated sequence

<400>  336

Met Ala Glu Gly Phe Ala Ala Asn Arg Gln Trp Ile Gly Pro Glu Glu 
1               5                   10                  15      


Ala Glu Glu Leu Leu Asp Phe Asp Ile Ala Thr Gln Met Ser Glu Glu 
            20                  25                  30          


Gly Pro Leu Asn Pro Gly Val Asn Pro Phe Arg Val Pro Gly Ile Thr 
        35                  40                  45              


Glu Lys Glu Lys Gln Asn Tyr Cys Asn Ile Leu Gln Pro Lys Leu Gln 
    50                  55                  60                  


Asp Leu Arg Asn Glu Ile Gln Glu Val Lys Leu Glu Glu Gly Asn Ala 
65                  70                  75                  80  


Gly Lys Phe Arg Arg Ala Arg Phe Leu Arg Tyr Ser Asp Glu Arg Val 
                85                  90                  95      


Leu Ser Leu Val His Ala Phe Ile Gly Tyr Cys Ile Tyr Leu Gly Asn 
            100                 105                 110         


Arg Asn Lys Leu Gly Ser Leu Arg His Asp Ile Asp Ile Glu Ala Pro 
        115                 120                 125             


Gln Glu Glu Cys Tyr Asn Asn Arg Glu Lys Gly Thr Thr Asp Asn Ile 
    130                 135                 140                 


Lys Tyr Gly Arg Arg Cys Cys Leu Gly Thr Val Thr Leu Tyr Leu Ile 
145                 150                 155                 160 


Leu Phe Thr Gly Val Ile Val Tyr Ser Gln Thr Ala Gly Ala Gln Val 
                165                 170                 175     


Val Trp Arg Leu Pro Pro Leu Val Val Pro Val Glu Glu Ser Glu Ile 
            180                 185                 190         


Ile Phe Trp Asp Cys Trp Ala Pro Glu Glu Pro Ala Cys Gln Asp Phe 
        195                 200                 205             


Leu Gly Ala Met Ile His Leu Lys Ala Lys Thr Asn Ile Ser Ile Arg 
    210                 215                 220                 


Glu Gly Pro Thr Leu Gly Asn Trp Ala Arg Glu Ile Trp Ala Thr Leu 
225                 230                 235                 240 


Phe Lys Lys Ala Thr Arg Gln Cys Arg Arg Gly Arg Ile Trp Lys Arg 
                245                 250                 255     


Trp Asn Glu Thr Ile Thr Gly Pro Ser Gly Cys Ala Asn Asn Thr Cys 
            260                 265                 270         


Tyr Asn Val Ser Val Ile Val Pro Asp Tyr Gln Cys Tyr Leu Asp Arg 
        275                 280                 285             


Val Asp Thr Trp Leu Gln Gly Lys Ile Asn Ile Ser Leu Cys Leu Thr 
    290                 295                 300                 


Gly Gly Lys Met Leu Tyr Asn Lys Val Thr Lys Gln Leu Ser Tyr Cys 
305                 310                 315                 320 


Thr Asp Pro Leu Gln Ile Pro Leu Ile Asn Tyr Thr Phe Gly Pro Asn 
                325                 330                 335     


Gln Thr Cys Met Trp Asn Thr Ser Gln Ile Gln Asp Pro Glu Ile Pro 
            340                 345                 350         


Lys Cys Gly Trp Trp Asn Gln Met Ala Tyr Tyr Asn Ser Cys Lys Trp 
        355                 360                 365             


Glu Glu Ala Lys Val Lys Phe His Cys Gln Arg Thr Gln Ser Gln Pro 
    370                 375                 380                 


Gly Ser Trp Phe Arg Ala Ile Ser Ser Trp Lys Gln Arg Asn Arg Trp 
385                 390                 395                 400 


Glu Trp Arg Pro Asp Phe Lys Ser Lys Lys Val Lys Ile Ser Leu Pro 
                405                 410                 415     


Cys Asn Ser Thr Lys Asn Leu Thr Phe Ala Met Arg Ser Ser Gly Asp 
            420                 425                 430         


Tyr Gly Glu Val Thr Gly Ala Trp Ile Glu Phe Gly Cys His Arg Asn 
        435                 440                 445             


Lys Ser Asn Leu His Thr Glu Ala Arg Phe Arg Ile Arg Cys Arg Trp 
    450                 455                 460                 


Asn Val Gly Ser Asp Thr Ser Leu Ile Asp Thr Cys Gly Asn Thr Pro 
465                 470                 475                 480 


Asn Val Ser Gly Ala Asn Pro Val Asp Cys Thr Met Tyr Ser Asn Lys 
                485                 490                 495     


Met Tyr Asn Cys Ser Leu Gln Asn Gly Phe Thr Met Lys Val Asp Asp 
            500                 505                 510         


Leu Ile Val His Phe Asn Met Thr Lys Ala Val Glu Met Tyr Asn Ile 
        515                 520                 525             


Ala Gly Asn Trp Ser Cys Thr Ser Asp Leu Pro Ser Ser Trp Gly Tyr 
    530                 535                 540                 


Met Asn Cys Asn Cys Thr Asn Ser Ser Ser Ser Tyr Ser Gly Thr Lys 
545                 550                 555                 560 


Met Ala Cys Pro Ser Asn Arg Gly Ile Leu Arg Asn Trp Tyr Asn Pro 
                565                 570                 575     


Val Ala Gly Leu Arg Gln Ser Leu Glu Gln Tyr Gln Val Val Lys Gln 
            580                 585                 590         


Pro Asp Tyr Leu Leu Val Pro Glu Glu Val Met Glu Tyr Lys Pro Arg 
        595                 600                 605             


Arg Lys Arg Ala Ala Ile His Val Met Leu Ala Leu Ala Thr Val Leu 
    610                 615                 620                 


Ser Ile Ala Gly Ala Gly Thr Gly Ala Thr Ala Ile Gly Met Val Thr 
625                 630                 635                 640 


Gln Tyr His Gln Val Leu Ala Thr His Gln Glu Ala Ile Glu Lys Val 
                645                 650                 655     


Thr Gly Ala Leu Lys Ile Asn Asn Leu Arg Leu Val Thr Leu Glu His 
            660                 665                 670         


Gln Val Leu Val Ile Gly Leu Lys Val Glu Ala Met Glu Lys Phe Leu 
        675                 680                 685             


Leu Thr Ala Phe Ala Met Gln Glu Leu Gly Cys Asn Gln Asn Gln Phe 
    690                 695                 700                 


Phe Cys Lys Ile Pro Leu Glu Leu Trp Thr Arg Tyr Asn Met Thr Ile 
705                 710                 715                 720 


Asn Gln Thr Ile Trp Asn His Gly Asn Ile Thr Leu Gly Glu Trp Tyr 
                725                 730                 735     


Asn Gln Thr Lys Asp Leu Gln Gln Lys Phe Tyr Glu Ile Ile Met Asp 
            740                 745                 750         


Ile Glu Gln Asn Asn Val Gln Gly Lys Thr Gly Ile Gln Gln Leu Gln 
        755                 760                 765             


Lys Trp Glu Asp Trp Val Arg Trp Ile Gly Asn Ile Pro Gln Tyr Leu 
    770                 775                 780                 


Lys Gly Leu Leu Gly Gly Ile Leu Gly Ile Gly Leu Gly Val Leu Leu 
785                 790                 795                 800 


Leu Ile Leu Cys Leu Pro Thr Leu Val Asp Cys Ile Arg Asn Cys Ile 
                805                 810                 815     


His Lys Ile Leu Gly Tyr Thr Val Ile Ala Met Pro Glu Val Glu Gly 
            820                 825                 830         


Glu Glu Ile Gln Pro Gln Met Glu Leu Arg Arg Asn Gly Arg Gln Cys 
        835                 840                 845             


Gly Met Ser Glu Lys Glu Glu Glu 
    850                 855     


<210>  337
<211>  856
<212>  PRT
<213>  Artificial sequence

<220>
<223>  Mutated sequence

<400>  337

Met Ala Glu Gly Phe Ala Ala Asn Arg Gln Trp Ile Gly Pro Glu Glu 
1               5                   10                  15      


Ala Glu Glu Leu Leu Asp Phe Asp Ile Ala Thr Gln Met Ser Glu Glu 
            20                  25                  30          


Gly Pro Leu Asn Pro Gly Val Asn Pro Phe Arg Val Pro Gly Ile Thr 
        35                  40                  45              


Glu Lys Glu Lys Gln Asn Tyr Cys Asn Ile Leu Gln Pro Lys Leu Gln 
    50                  55                  60                  


Asp Leu Arg Asn Glu Ile Gln Glu Val Lys Leu Glu Glu Gly Asn Ala 
65                  70                  75                  80  


Gly Lys Phe Arg Arg Ala Arg Phe Leu Arg Tyr Ser Asp Glu Arg Val 
                85                  90                  95      


Leu Ser Leu Val His Ala Phe Ile Gly Tyr Cys Ile Tyr Leu Gly Asn 
            100                 105                 110         


Arg Asn Lys Leu Gly Ser Leu Arg His Asp Ile Asp Ile Glu Ala Pro 
        115                 120                 125             


Gln Glu Glu Cys Tyr Asn Asn Arg Glu Lys Gly Thr Thr Asp Asn Ile 
    130                 135                 140                 


Lys Tyr Gly Arg Arg Cys Cys Leu Gly Thr Val Thr Leu Tyr Leu Ile 
145                 150                 155                 160 


Leu Phe Thr Gly Val Ile Val Tyr Ser Gln Thr Ala Gly Ala Gln Val 
                165                 170                 175     


Val Trp Arg Leu Pro Pro Leu Val Val Pro Val Glu Glu Ser Glu Ile 
            180                 185                 190         


Ile Phe Trp Asp Cys Trp Ala Pro Glu Glu Pro Ala Cys Gln Asp Phe 
        195                 200                 205             


Leu Gly Ala Met Ile His Leu Lys Ala Lys Thr Asn Ile Ser Ile Arg 
    210                 215                 220                 


Glu Gly Pro Thr Leu Gly Asn Trp Ala Arg Glu Ile Trp Ala Thr Leu 
225                 230                 235                 240 


Phe Lys Lys Ala Thr Arg Gln Cys Arg Arg Gly Arg Ile Trp Lys Arg 
                245                 250                 255     


Trp Asn Glu Thr Ile Thr Gly Pro Ser Gly Cys Ala Asn Asn Thr Cys 
            260                 265                 270         


Tyr Asn Val Ser Val Ile Val Pro Asp Tyr Gln Cys Tyr Leu Asp Arg 
        275                 280                 285             


Val Asp Thr Trp Leu Gln Gly Lys Ile Asn Ile Ser Leu Cys Leu Thr 
    290                 295                 300                 


Gly Gly Lys Met Leu Tyr Asn Lys Val Thr Lys Gln Leu Ser Tyr Cys 
305                 310                 315                 320 


Thr Asp Pro Leu Gln Ile Pro Leu Ile Asn Tyr Thr Phe Gly Pro Asn 
                325                 330                 335     


Gln Thr Cys Met Trp Asn Thr Ser Gln Ile Gln Asp Pro Glu Ile Pro 
            340                 345                 350         


Lys Cys Gly Trp Trp Asn Gln Met Ala Tyr Tyr Asn Ser Cys Lys Trp 
        355                 360                 365             


Glu Glu Ala Lys Val Lys Phe His Cys Gln Arg Thr Gln Ser Gln Pro 
    370                 375                 380                 


Gly Ser Trp Phe Arg Ala Ile Ser Ser Trp Lys Gln Arg Asn Arg Trp 
385                 390                 395                 400 


Glu Trp Arg Pro Asp Phe Lys Ser Lys Lys Val Lys Ile Ser Leu Pro 
                405                 410                 415     


Cys Asn Ser Thr Lys Asn Leu Thr Phe Ala Met Arg Ser Ser Gly Asp 
            420                 425                 430         


Tyr Gly Glu Val Thr Gly Ala Trp Ile Glu Phe Gly Cys His Arg Asn 
        435                 440                 445             


Lys Ser Asn Leu His Thr Glu Ala Arg Phe Arg Ile Arg Cys Arg Trp 
    450                 455                 460                 


Asn Val Gly Ser Asp Thr Ser Leu Ile Asp Thr Cys Gly Asn Thr Pro 
465                 470                 475                 480 


Asn Val Ser Gly Ala Asn Pro Val Asp Cys Thr Met Tyr Ser Asn Lys 
                485                 490                 495     


Met Tyr Asn Cys Ser Leu Gln Asn Gly Phe Thr Met Lys Val Asp Asp 
            500                 505                 510         


Leu Ile Val His Phe Asn Met Thr Lys Ala Val Glu Met Tyr Asn Ile 
        515                 520                 525             


Ala Gly Asn Trp Ser Cys Thr Ser Asp Leu Pro Ser Ser Trp Gly Tyr 
    530                 535                 540                 


Met Asn Cys Asn Cys Thr Asn Ser Ser Ser Ser Tyr Ser Gly Thr Lys 
545                 550                 555                 560 


Met Ala Cys Pro Ser Asn Arg Gly Ile Leu Arg Asn Trp Tyr Asn Pro 
                565                 570                 575     


Val Ala Gly Leu Arg Gln Ser Leu Glu Gln Tyr Gln Val Val Lys Gln 
            580                 585                 590         


Pro Asp Tyr Leu Leu Val Pro Glu Glu Val Met Glu Tyr Lys Pro Arg 
        595                 600                 605             


Arg Lys Arg Ala Ala Ile His Val Met Leu Ala Leu Ala Thr Val Leu 
    610                 615                 620                 


Ser Ile Ala Gly Ala Gly Thr Gly Ala Thr Ala Ile Gly Met Val Thr 
625                 630                 635                 640 


Gln Tyr His Gln Val Leu Ala Thr His Gln Glu Ala Ile Glu Lys Val 
                645                 650                 655     


Thr Gly Ala Leu Lys Ile Asn Asn Leu Arg Leu Val Thr Leu Glu His 
            660                 665                 670         


Gln Val Leu Val Ile Gly Leu Lys Val Glu Ala Met Glu Lys Phe Leu 
        675                 680                 685             


Ala Thr Ala Phe Ala Met Gln Glu Leu Gly Cys Asn Gln Asn Gln Phe 
    690                 695                 700                 


Phe Cys Lys Ile Pro Leu Glu Leu Trp Thr Arg Tyr Asn Met Thr Ile 
705                 710                 715                 720 


Asn Gln Thr Ile Trp Asn His Gly Asn Ile Thr Leu Gly Glu Trp Tyr 
                725                 730                 735     


Asn Gln Thr Lys Asp Leu Gln Gln Lys Phe Tyr Glu Ile Ile Met Asp 
            740                 745                 750         


Ile Glu Gln Asn Asn Val Gln Gly Lys Thr Gly Ile Gln Gln Leu Gln 
        755                 760                 765             


Lys Trp Glu Asp Trp Val Arg Trp Ile Gly Asn Ile Pro Gln Tyr Leu 
    770                 775                 780                 


Lys Gly Leu Leu Gly Gly Ile Leu Gly Ile Gly Leu Gly Val Leu Leu 
785                 790                 795                 800 


Leu Ile Leu Cys Leu Pro Thr Leu Val Asp Cys Ile Arg Asn Cys Ile 
                805                 810                 815     


His Lys Ile Leu Gly Tyr Thr Val Ile Ala Met Pro Glu Val Glu Gly 
            820                 825                 830         


Glu Glu Ile Gln Pro Gln Met Glu Leu Arg Arg Asn Gly Arg Gln Cys 
        835                 840                 845             


Gly Met Ser Glu Lys Glu Glu Glu 
    850                 855     


<210>  338
<211>  856
<212>  PRT
<213>  Artificial sequence

<220>
<223>  Mutated sequence

<400>  338

Met Ala Glu Gly Phe Ala Ala Asn Arg Gln Trp Ile Gly Pro Glu Glu 
1               5                   10                  15      


Ala Glu Glu Leu Leu Asp Phe Asp Ile Ala Thr Gln Met Ser Glu Glu 
            20                  25                  30          


Gly Pro Leu Asn Pro Gly Val Asn Pro Phe Arg Val Pro Gly Ile Thr 
        35                  40                  45              


Glu Lys Glu Lys Gln Asn Tyr Cys Asn Ile Leu Gln Pro Lys Leu Gln 
    50                  55                  60                  


Asp Leu Arg Asn Glu Ile Gln Glu Val Lys Leu Glu Glu Gly Asn Ala 
65                  70                  75                  80  


Gly Lys Phe Arg Arg Ala Arg Phe Leu Arg Tyr Ser Asp Glu Arg Val 
                85                  90                  95      


Leu Ser Leu Val His Ala Phe Ile Gly Tyr Cys Ile Tyr Leu Gly Asn 
            100                 105                 110         


Arg Asn Lys Leu Gly Ser Leu Arg His Asp Ile Asp Ile Glu Ala Pro 
        115                 120                 125             


Gln Glu Glu Cys Tyr Asn Asn Arg Glu Lys Gly Thr Thr Asp Asn Ile 
    130                 135                 140                 


Lys Tyr Gly Arg Arg Cys Cys Leu Gly Thr Val Thr Leu Tyr Leu Ile 
145                 150                 155                 160 


Leu Phe Thr Gly Val Ile Val Tyr Ser Gln Thr Ala Gly Ala Gln Val 
                165                 170                 175     


Val Trp Arg Leu Pro Pro Leu Val Val Pro Val Glu Glu Ser Glu Ile 
            180                 185                 190         


Ile Phe Trp Asp Cys Trp Ala Pro Glu Glu Pro Ala Cys Gln Asp Phe 
        195                 200                 205             


Leu Gly Ala Met Ile His Leu Lys Ala Lys Thr Asn Ile Ser Ile Arg 
    210                 215                 220                 


Glu Gly Pro Thr Leu Gly Asn Trp Ala Arg Glu Ile Trp Ala Thr Leu 
225                 230                 235                 240 


Phe Lys Lys Ala Thr Arg Gln Cys Arg Arg Gly Arg Ile Trp Lys Arg 
                245                 250                 255     


Trp Asn Glu Thr Ile Thr Gly Pro Ser Gly Cys Ala Asn Asn Thr Cys 
            260                 265                 270         


Tyr Asn Val Ser Val Ile Val Pro Asp Tyr Gln Cys Tyr Leu Asp Arg 
        275                 280                 285             


Val Asp Thr Trp Leu Gln Gly Lys Ile Asn Ile Ser Leu Cys Leu Thr 
    290                 295                 300                 


Gly Gly Lys Met Leu Tyr Asn Lys Val Thr Lys Gln Leu Ser Tyr Cys 
305                 310                 315                 320 


Thr Asp Pro Leu Gln Ile Pro Leu Ile Asn Tyr Thr Phe Gly Pro Asn 
                325                 330                 335     


Gln Thr Cys Met Trp Asn Thr Ser Gln Ile Gln Asp Pro Glu Ile Pro 
            340                 345                 350         


Lys Cys Gly Trp Trp Asn Gln Met Ala Tyr Tyr Asn Ser Cys Lys Trp 
        355                 360                 365             


Glu Glu Ala Lys Val Lys Phe His Cys Gln Arg Thr Gln Ser Gln Pro 
    370                 375                 380                 


Gly Ser Trp Phe Arg Ala Ile Ser Ser Trp Lys Gln Arg Asn Arg Trp 
385                 390                 395                 400 


Glu Trp Arg Pro Asp Phe Lys Ser Lys Lys Val Lys Ile Ser Leu Pro 
                405                 410                 415     


Cys Asn Ser Thr Lys Asn Leu Thr Phe Ala Met Arg Ser Ser Gly Asp 
            420                 425                 430         


Tyr Gly Glu Val Thr Gly Ala Trp Ile Glu Phe Gly Cys His Arg Asn 
        435                 440                 445             


Lys Ser Asn Leu His Thr Glu Ala Arg Phe Arg Ile Arg Cys Arg Trp 
    450                 455                 460                 


Asn Val Gly Ser Asp Thr Ser Leu Ile Asp Thr Cys Gly Asn Thr Pro 
465                 470                 475                 480 


Asn Val Ser Gly Ala Asn Pro Val Asp Cys Thr Met Tyr Ser Asn Lys 
                485                 490                 495     


Met Tyr Asn Cys Ser Leu Gln Asn Gly Phe Thr Met Lys Val Asp Asp 
            500                 505                 510         


Leu Ile Val His Phe Asn Met Thr Lys Ala Val Glu Met Tyr Asn Ile 
        515                 520                 525             


Ala Gly Asn Trp Ser Cys Thr Ser Asp Leu Pro Ser Ser Trp Gly Tyr 
    530                 535                 540                 


Met Asn Cys Asn Cys Thr Asn Ser Ser Ser Ser Tyr Ser Gly Thr Lys 
545                 550                 555                 560 


Met Ala Cys Pro Ser Asn Arg Gly Ile Leu Arg Asn Trp Tyr Asn Pro 
                565                 570                 575     


Val Ala Gly Leu Arg Gln Ser Leu Glu Gln Tyr Gln Val Val Lys Gln 
            580                 585                 590         


Pro Asp Tyr Leu Leu Val Pro Glu Glu Val Met Glu Tyr Lys Pro Arg 
        595                 600                 605             


Arg Lys Arg Ala Ala Ile His Val Met Leu Ala Leu Ala Thr Val Leu 
    610                 615                 620                 


Ser Ile Ala Gly Ala Gly Thr Gly Ala Thr Ala Ile Gly Met Val Thr 
625                 630                 635                 640 


Gln Tyr His Gln Val Leu Ala Thr His Gln Glu Ala Ile Glu Lys Val 
                645                 650                 655     


Thr Gly Ala Leu Lys Ile Asn Asn Leu Arg Leu Val Thr Leu Glu His 
            660                 665                 670         


Gln Val Leu Val Ile Gly Leu Lys Val Glu Ala Met Glu Lys Phe Leu 
        675                 680                 685             


Phe Thr Ala Phe Ala Met Gln Glu Leu Gly Cys Asn Gln Asn Gln Phe 
    690                 695                 700                 


Phe Cys Lys Ile Pro Leu Glu Leu Trp Thr Arg Tyr Asn Met Thr Ile 
705                 710                 715                 720 


Asn Gln Thr Ile Trp Asn His Gly Asn Ile Thr Leu Gly Glu Trp Tyr 
                725                 730                 735     


Asn Gln Thr Lys Asp Leu Gln Gln Lys Phe Tyr Glu Ile Ile Met Asp 
            740                 745                 750         


Ile Glu Gln Asn Asn Val Gln Gly Lys Thr Gly Ile Gln Gln Leu Gln 
        755                 760                 765             


Lys Trp Glu Asp Trp Val Arg Trp Ile Gly Asn Ile Pro Gln Tyr Leu 
    770                 775                 780                 


Lys Gly Leu Leu Gly Gly Ile Leu Gly Ile Gly Leu Gly Val Leu Leu 
785                 790                 795                 800 


Leu Ile Leu Cys Leu Pro Thr Leu Val Asp Cys Ile Arg Asn Cys Ile 
                805                 810                 815     


His Lys Ile Leu Gly Tyr Thr Val Ile Ala Met Pro Glu Val Glu Gly 
            820                 825                 830         


Glu Glu Ile Gln Pro Gln Met Glu Leu Arg Arg Asn Gly Arg Gln Cys 
        835                 840                 845             


Gly Met Ser Glu Lys Glu Glu Glu 
    850                 855     


<210>  339
<211>  856
<212>  PRT
<213>  Artificial sequence

<220>
<223>  Mutated sequence

<400>  339

Met Ala Glu Gly Phe Ala Ala Asn Arg Gln Trp Ile Gly Pro Glu Glu 
1               5                   10                  15      


Ala Glu Glu Leu Leu Asp Phe Asp Ile Ala Thr Gln Met Ser Glu Glu 
            20                  25                  30          


Gly Pro Leu Asn Pro Gly Val Asn Pro Phe Arg Val Pro Gly Ile Thr 
        35                  40                  45              


Glu Lys Glu Lys Gln Asn Tyr Cys Asn Ile Leu Gln Pro Lys Leu Gln 
    50                  55                  60                  


Asp Leu Arg Asn Glu Ile Gln Glu Val Lys Leu Glu Glu Gly Asn Ala 
65                  70                  75                  80  


Gly Lys Phe Arg Arg Ala Arg Phe Leu Arg Tyr Ser Asp Glu Arg Val 
                85                  90                  95      


Leu Ser Leu Val His Ala Phe Ile Gly Tyr Cys Ile Tyr Leu Gly Asn 
            100                 105                 110         


Arg Asn Lys Leu Gly Ser Leu Arg His Asp Ile Asp Ile Glu Ala Pro 
        115                 120                 125             


Gln Glu Glu Cys Tyr Asn Asn Arg Glu Lys Gly Thr Thr Asp Asn Ile 
    130                 135                 140                 


Lys Tyr Gly Arg Arg Cys Cys Leu Gly Thr Val Thr Leu Tyr Leu Ile 
145                 150                 155                 160 


Leu Phe Thr Gly Val Ile Val Tyr Ser Gln Thr Ala Gly Ala Gln Val 
                165                 170                 175     


Val Trp Arg Leu Pro Pro Leu Val Val Pro Val Glu Glu Ser Glu Ile 
            180                 185                 190         


Ile Phe Trp Asp Cys Trp Ala Pro Glu Glu Pro Ala Cys Gln Asp Phe 
        195                 200                 205             


Leu Gly Ala Met Ile His Leu Lys Ala Lys Thr Asn Ile Ser Ile Arg 
    210                 215                 220                 


Glu Gly Pro Thr Leu Gly Asn Trp Ala Arg Glu Ile Trp Ala Thr Leu 
225                 230                 235                 240 


Phe Lys Lys Ala Thr Arg Gln Cys Arg Arg Gly Arg Ile Trp Lys Arg 
                245                 250                 255     


Trp Asn Glu Thr Ile Thr Gly Pro Ser Gly Cys Ala Asn Asn Thr Cys 
            260                 265                 270         


Tyr Asn Val Ser Val Ile Val Pro Asp Tyr Gln Cys Tyr Leu Asp Arg 
        275                 280                 285             


Val Asp Thr Trp Leu Gln Gly Lys Ile Asn Ile Ser Leu Cys Leu Thr 
    290                 295                 300                 


Gly Gly Lys Met Leu Tyr Asn Lys Val Thr Lys Gln Leu Ser Tyr Cys 
305                 310                 315                 320 


Thr Asp Pro Leu Gln Ile Pro Leu Ile Asn Tyr Thr Phe Gly Pro Asn 
                325                 330                 335     


Gln Thr Cys Met Trp Asn Thr Ser Gln Ile Gln Asp Pro Glu Ile Pro 
            340                 345                 350         


Lys Cys Gly Trp Trp Asn Gln Met Ala Tyr Tyr Asn Ser Cys Lys Trp 
        355                 360                 365             


Glu Glu Ala Lys Val Lys Phe His Cys Gln Arg Thr Gln Ser Gln Pro 
    370                 375                 380                 


Gly Ser Trp Phe Arg Ala Ile Ser Ser Trp Lys Gln Arg Asn Arg Trp 
385                 390                 395                 400 


Glu Trp Arg Pro Asp Phe Lys Ser Lys Lys Val Lys Ile Ser Leu Pro 
                405                 410                 415     


Cys Asn Ser Thr Lys Asn Leu Thr Phe Ala Met Arg Ser Ser Gly Asp 
            420                 425                 430         


Tyr Gly Glu Val Thr Gly Ala Trp Ile Glu Phe Gly Cys His Arg Asn 
        435                 440                 445             


Lys Ser Asn Leu His Thr Glu Ala Arg Phe Arg Ile Arg Cys Arg Trp 
    450                 455                 460                 


Asn Val Gly Ser Asp Thr Ser Leu Ile Asp Thr Cys Gly Asn Thr Pro 
465                 470                 475                 480 


Asn Val Ser Gly Ala Asn Pro Val Asp Cys Thr Met Tyr Ser Asn Lys 
                485                 490                 495     


Met Tyr Asn Cys Ser Leu Gln Asn Gly Phe Thr Met Lys Val Asp Asp 
            500                 505                 510         


Leu Ile Val His Phe Asn Met Thr Lys Ala Val Glu Met Tyr Asn Ile 
        515                 520                 525             


Ala Gly Asn Trp Ser Cys Thr Ser Asp Leu Pro Ser Ser Trp Gly Tyr 
    530                 535                 540                 


Met Asn Cys Asn Cys Thr Asn Ser Ser Ser Ser Tyr Ser Gly Thr Lys 
545                 550                 555                 560 


Met Ala Cys Pro Ser Asn Arg Gly Ile Leu Arg Asn Trp Tyr Asn Pro 
                565                 570                 575     


Val Ala Gly Leu Arg Gln Ser Leu Glu Gln Tyr Gln Val Val Lys Gln 
            580                 585                 590         


Pro Asp Tyr Leu Leu Val Pro Glu Glu Val Met Glu Tyr Lys Pro Arg 
        595                 600                 605             


Arg Lys Arg Ala Ala Ile His Val Met Leu Ala Leu Ala Thr Val Leu 
    610                 615                 620                 


Ser Ile Ala Gly Ala Gly Thr Gly Ala Thr Ala Ile Gly Met Val Thr 
625                 630                 635                 640 


Gln Tyr His Gln Val Leu Ala Thr His Gln Glu Ala Ile Glu Lys Val 
                645                 650                 655     


Thr Gly Ala Leu Lys Ile Asn Asn Leu Arg Leu Val Thr Leu Glu His 
            660                 665                 670         


Gln Val Leu Val Ile Gly Leu Lys Val Glu Ala Met Glu Lys Arg Arg 
        675                 680                 685             


Tyr Thr Ala Phe Ala Met Gln Glu Leu Gly Cys Asn Gln Asn Gln Phe 
    690                 695                 700                 


Phe Cys Lys Ile Pro Leu Glu Leu Trp Thr Arg Tyr Asn Met Thr Ile 
705                 710                 715                 720 


Asn Gln Thr Ile Trp Asn His Gly Asn Ile Thr Leu Gly Glu Trp Tyr 
                725                 730                 735     


Asn Gln Thr Lys Asp Leu Gln Gln Lys Phe Tyr Glu Ile Ile Met Asp 
            740                 745                 750         


Ile Glu Gln Asn Asn Val Gln Gly Lys Thr Gly Ile Gln Gln Leu Gln 
        755                 760                 765             


Lys Trp Glu Asp Trp Val Arg Trp Ile Gly Asn Ile Pro Gln Tyr Leu 
    770                 775                 780                 


Lys Gly Leu Leu Gly Gly Ile Leu Gly Ile Gly Leu Gly Val Leu Leu 
785                 790                 795                 800 


Leu Ile Leu Cys Leu Pro Thr Leu Val Asp Cys Ile Arg Asn Cys Ile 
                805                 810                 815     


His Lys Ile Leu Gly Tyr Thr Val Ile Ala Met Pro Glu Val Glu Gly 
            820                 825                 830         


Glu Glu Ile Gln Pro Gln Met Glu Leu Arg Arg Asn Gly Arg Gln Cys 
        835                 840                 845             


Gly Met Ser Glu Lys Glu Glu Glu 
    850                 855     


<210>  340
<211>  856
<212>  PRT
<213>  Artificial sequence

<220>
<223>  Mutated sequence

<400>  340

Met Ala Glu Gly Phe Ala Ala Asn Arg Gln Trp Ile Gly Pro Glu Glu 
1               5                   10                  15      


Ala Glu Glu Leu Leu Asp Phe Asp Ile Ala Thr Gln Met Ser Glu Glu 
            20                  25                  30          


Gly Pro Leu Asn Pro Gly Val Asn Pro Phe Arg Val Pro Gly Ile Thr 
        35                  40                  45              


Glu Lys Glu Lys Gln Asn Tyr Cys Asn Ile Leu Gln Pro Lys Leu Gln 
    50                  55                  60                  


Asp Leu Arg Asn Glu Ile Gln Glu Val Lys Leu Glu Glu Gly Asn Ala 
65                  70                  75                  80  


Gly Lys Phe Arg Arg Ala Arg Phe Leu Arg Tyr Ser Asp Glu Arg Val 
                85                  90                  95      


Leu Ser Leu Val His Ala Phe Ile Gly Tyr Cys Ile Tyr Leu Gly Asn 
            100                 105                 110         


Arg Asn Lys Leu Gly Ser Leu Arg His Asp Ile Asp Ile Glu Ala Pro 
        115                 120                 125             


Gln Glu Glu Cys Tyr Asn Asn Arg Glu Lys Gly Thr Thr Asp Asn Ile 
    130                 135                 140                 


Lys Tyr Gly Arg Arg Cys Cys Leu Gly Thr Val Thr Leu Tyr Leu Ile 
145                 150                 155                 160 


Leu Phe Thr Gly Val Ile Val Tyr Ser Gln Thr Ala Gly Ala Gln Val 
                165                 170                 175     


Val Trp Arg Leu Pro Pro Leu Val Val Pro Val Glu Glu Ser Glu Ile 
            180                 185                 190         


Ile Phe Trp Asp Cys Trp Ala Pro Glu Glu Pro Ala Cys Gln Asp Phe 
        195                 200                 205             


Leu Gly Ala Met Ile His Leu Lys Ala Lys Thr Asn Ile Ser Ile Arg 
    210                 215                 220                 


Glu Gly Pro Thr Leu Gly Asn Trp Ala Arg Glu Ile Trp Ala Thr Leu 
225                 230                 235                 240 


Phe Lys Lys Ala Thr Arg Gln Cys Arg Arg Gly Arg Ile Trp Lys Arg 
                245                 250                 255     


Trp Asn Glu Thr Ile Thr Gly Pro Ser Gly Cys Ala Asn Asn Thr Cys 
            260                 265                 270         


Tyr Asn Val Ser Val Ile Val Pro Asp Tyr Gln Cys Tyr Leu Asp Arg 
        275                 280                 285             


Val Asp Thr Trp Leu Gln Gly Lys Ile Asn Ile Ser Leu Cys Leu Thr 
    290                 295                 300                 


Gly Gly Lys Met Leu Tyr Asn Lys Val Thr Lys Gln Leu Ser Tyr Cys 
305                 310                 315                 320 


Thr Asp Pro Leu Gln Ile Pro Leu Ile Asn Tyr Thr Phe Gly Pro Asn 
                325                 330                 335     


Gln Thr Cys Met Trp Asn Thr Ser Gln Ile Gln Asp Pro Glu Ile Pro 
            340                 345                 350         


Lys Cys Gly Trp Trp Asn Gln Met Ala Tyr Tyr Asn Ser Cys Lys Trp 
        355                 360                 365             


Glu Glu Ala Lys Val Lys Phe His Cys Gln Arg Thr Gln Ser Gln Pro 
    370                 375                 380                 


Gly Ser Trp Phe Arg Ala Ile Ser Ser Trp Lys Gln Arg Asn Arg Trp 
385                 390                 395                 400 


Glu Trp Arg Pro Asp Phe Lys Ser Lys Lys Val Lys Ile Ser Leu Pro 
                405                 410                 415     


Cys Asn Ser Thr Lys Asn Leu Thr Phe Ala Met Arg Ser Ser Gly Asp 
            420                 425                 430         


Tyr Gly Glu Val Thr Gly Ala Trp Ile Glu Phe Gly Cys His Arg Asn 
        435                 440                 445             


Lys Ser Asn Leu His Thr Glu Ala Arg Phe Arg Ile Arg Cys Arg Trp 
    450                 455                 460                 


Asn Val Gly Ser Asp Thr Ser Leu Ile Asp Thr Cys Gly Asn Thr Pro 
465                 470                 475                 480 


Asn Val Ser Gly Ala Asn Pro Val Asp Cys Thr Met Tyr Ser Asn Lys 
                485                 490                 495     


Met Tyr Asn Cys Ser Leu Gln Asn Gly Phe Thr Met Lys Val Asp Asp 
            500                 505                 510         


Leu Ile Val His Phe Asn Met Thr Lys Ala Val Glu Met Tyr Asn Ile 
        515                 520                 525             


Ala Gly Asn Trp Ser Cys Thr Ser Asp Leu Pro Ser Ser Trp Gly Tyr 
    530                 535                 540                 


Met Asn Cys Asn Cys Thr Asn Ser Ser Ser Ser Tyr Ser Gly Thr Lys 
545                 550                 555                 560 


Met Ala Cys Pro Ser Asn Arg Gly Ile Leu Arg Asn Trp Tyr Asn Pro 
                565                 570                 575     


Val Ala Gly Leu Arg Gln Ser Leu Glu Gln Tyr Gln Val Val Lys Gln 
            580                 585                 590         


Pro Asp Tyr Leu Leu Val Pro Glu Glu Val Met Glu Tyr Lys Pro Arg 
        595                 600                 605             


Arg Lys Arg Ala Ala Ile His Val Met Leu Ala Leu Ala Thr Val Leu 
    610                 615                 620                 


Ser Ile Ala Gly Ala Gly Thr Gly Ala Thr Ala Ile Gly Met Val Thr 
625                 630                 635                 640 


Gln Tyr His Gln Val Leu Ala Thr His Gln Glu Ala Ile Glu Lys Val 
                645                 650                 655     


Thr Gly Ala Leu Lys Ile Asn Asn Leu Arg Leu Val Thr Leu Glu His 
            660                 665                 670         


Gln Val Leu Val Ile Gly Leu Lys Val Glu Ala Met Glu Lys Arg Gly 
        675                 680                 685             


Tyr Thr Ala Phe Ala Met Gln Glu Leu Gly Cys Asn Gln Asn Gln Phe 
    690                 695                 700                 


Phe Cys Lys Ile Pro Leu Glu Leu Trp Thr Arg Tyr Asn Met Thr Ile 
705                 710                 715                 720 


Asn Gln Thr Ile Trp Asn His Gly Asn Ile Thr Leu Gly Glu Trp Tyr 
                725                 730                 735     


Asn Gln Thr Lys Asp Leu Gln Gln Lys Phe Tyr Glu Ile Ile Met Asp 
            740                 745                 750         


Ile Glu Gln Asn Asn Val Gln Gly Lys Thr Gly Ile Gln Gln Leu Gln 
        755                 760                 765             


Lys Trp Glu Asp Trp Val Arg Trp Ile Gly Asn Ile Pro Gln Tyr Leu 
    770                 775                 780                 


Lys Gly Leu Leu Gly Gly Ile Leu Gly Ile Gly Leu Gly Val Leu Leu 
785                 790                 795                 800 


Leu Ile Leu Cys Leu Pro Thr Leu Val Asp Cys Ile Arg Asn Cys Ile 
                805                 810                 815     


His Lys Ile Leu Gly Tyr Thr Val Ile Ala Met Pro Glu Val Glu Gly 
            820                 825                 830         


Glu Glu Ile Gln Pro Gln Met Glu Leu Arg Arg Asn Gly Arg Gln Cys 
        835                 840                 845             


Gly Met Ser Glu Lys Glu Glu Glu 
    850                 855     


<210>  341
<211>  856
<212>  PRT
<213>  Artificial sequence

<220>
<223>  Mutated sequence

<400>  341

Met Ala Glu Gly Phe Ala Ala Asn Arg Gln Trp Ile Gly Pro Glu Glu 
1               5                   10                  15      


Ala Glu Glu Leu Leu Asp Phe Asp Ile Ala Thr Gln Met Ser Glu Glu 
            20                  25                  30          


Gly Pro Leu Asn Pro Gly Val Asn Pro Phe Arg Val Pro Gly Ile Thr 
        35                  40                  45              


Glu Lys Glu Lys Gln Asn Tyr Cys Asn Ile Leu Gln Pro Lys Leu Gln 
    50                  55                  60                  


Asp Leu Arg Asn Glu Ile Gln Glu Val Lys Leu Glu Glu Gly Asn Ala 
65                  70                  75                  80  


Gly Lys Phe Arg Arg Ala Arg Phe Leu Arg Tyr Ser Asp Glu Arg Val 
                85                  90                  95      


Leu Ser Leu Val His Ala Phe Ile Gly Tyr Cys Ile Tyr Leu Gly Asn 
            100                 105                 110         


Arg Asn Lys Leu Gly Ser Leu Arg His Asp Ile Asp Ile Glu Ala Pro 
        115                 120                 125             


Gln Glu Glu Cys Tyr Asn Asn Arg Glu Lys Gly Thr Thr Asp Asn Ile 
    130                 135                 140                 


Lys Tyr Gly Arg Arg Cys Cys Leu Gly Thr Val Thr Leu Tyr Leu Ile 
145                 150                 155                 160 


Leu Phe Thr Gly Val Ile Val Tyr Ser Gln Thr Ala Gly Ala Gln Val 
                165                 170                 175     


Val Trp Arg Leu Pro Pro Leu Val Val Pro Val Glu Glu Ser Glu Ile 
            180                 185                 190         


Ile Phe Trp Asp Cys Trp Ala Pro Glu Glu Pro Ala Cys Gln Asp Phe 
        195                 200                 205             


Leu Gly Ala Met Ile His Leu Lys Ala Lys Thr Asn Ile Ser Ile Arg 
    210                 215                 220                 


Glu Gly Pro Thr Leu Gly Asn Trp Ala Arg Glu Ile Trp Ala Thr Leu 
225                 230                 235                 240 


Phe Lys Lys Ala Thr Arg Gln Cys Arg Arg Gly Arg Ile Trp Lys Arg 
                245                 250                 255     


Trp Asn Glu Thr Ile Thr Gly Pro Ser Gly Cys Ala Asn Asn Thr Cys 
            260                 265                 270         


Tyr Asn Val Ser Val Ile Val Pro Asp Tyr Gln Cys Tyr Leu Asp Arg 
        275                 280                 285             


Val Asp Thr Trp Leu Gln Gly Lys Ile Asn Ile Ser Leu Cys Leu Thr 
    290                 295                 300                 


Gly Gly Lys Met Leu Tyr Asn Lys Val Thr Lys Gln Leu Ser Tyr Cys 
305                 310                 315                 320 


Thr Asp Pro Leu Gln Ile Pro Leu Ile Asn Tyr Thr Phe Gly Pro Asn 
                325                 330                 335     


Gln Thr Cys Met Trp Asn Thr Ser Gln Ile Gln Asp Pro Glu Ile Pro 
            340                 345                 350         


Lys Cys Gly Trp Trp Asn Gln Met Ala Tyr Tyr Asn Ser Cys Lys Trp 
        355                 360                 365             


Glu Glu Ala Lys Val Lys Phe His Cys Gln Arg Thr Gln Ser Gln Pro 
    370                 375                 380                 


Gly Ser Trp Phe Arg Ala Ile Ser Ser Trp Lys Gln Arg Asn Arg Trp 
385                 390                 395                 400 


Glu Trp Arg Pro Asp Phe Lys Ser Lys Lys Val Lys Ile Ser Leu Pro 
                405                 410                 415     


Cys Asn Ser Thr Lys Asn Leu Thr Phe Ala Met Arg Ser Ser Gly Asp 
            420                 425                 430         


Tyr Gly Glu Val Thr Gly Ala Trp Ile Glu Phe Gly Cys His Arg Asn 
        435                 440                 445             


Lys Ser Asn Leu His Thr Glu Ala Arg Phe Arg Ile Arg Cys Arg Trp 
    450                 455                 460                 


Asn Val Gly Ser Asp Thr Ser Leu Ile Asp Thr Cys Gly Asn Thr Pro 
465                 470                 475                 480 


Asn Val Ser Gly Ala Asn Pro Val Asp Cys Thr Met Tyr Ser Asn Lys 
                485                 490                 495     


Met Tyr Asn Cys Ser Leu Gln Asn Gly Phe Thr Met Lys Val Asp Asp 
            500                 505                 510         


Leu Ile Val His Phe Asn Met Thr Lys Ala Val Glu Met Tyr Asn Ile 
        515                 520                 525             


Ala Gly Asn Trp Ser Cys Thr Ser Asp Leu Pro Ser Ser Trp Gly Tyr 
    530                 535                 540                 


Met Asn Cys Asn Cys Thr Asn Ser Ser Ser Ser Tyr Ser Gly Thr Lys 
545                 550                 555                 560 


Met Ala Cys Pro Ser Asn Arg Gly Ile Leu Arg Asn Trp Tyr Asn Pro 
                565                 570                 575     


Val Ala Gly Leu Arg Gln Ser Leu Glu Gln Tyr Gln Val Val Lys Gln 
            580                 585                 590         


Pro Asp Tyr Leu Leu Val Pro Glu Glu Val Met Glu Tyr Lys Pro Arg 
        595                 600                 605             


Arg Lys Arg Ala Ala Ile His Val Met Leu Ala Leu Ala Thr Val Leu 
    610                 615                 620                 


Ser Ile Ala Gly Ala Gly Thr Gly Ala Thr Ala Ile Gly Met Val Thr 
625                 630                 635                 640 


Gln Tyr His Gln Val Leu Ala Thr His Gln Glu Ala Ile Glu Lys Val 
                645                 650                 655     


Thr Gly Ala Leu Lys Ile Asn Asn Leu Arg Leu Val Thr Leu Glu His 
            660                 665                 670         


Gln Val Leu Val Ile Gly Leu Lys Val Glu Ala Met Glu Lys Arg Ala 
        675                 680                 685             


Tyr Thr Ala Phe Ala Met Gln Glu Leu Gly Cys Asn Gln Asn Gln Phe 
    690                 695                 700                 


Phe Cys Lys Ile Pro Leu Glu Leu Trp Thr Arg Tyr Asn Met Thr Ile 
705                 710                 715                 720 


Asn Gln Thr Ile Trp Asn His Gly Asn Ile Thr Leu Gly Glu Trp Tyr 
                725                 730                 735     


Asn Gln Thr Lys Asp Leu Gln Gln Lys Phe Tyr Glu Ile Ile Met Asp 
            740                 745                 750         


Ile Glu Gln Asn Asn Val Gln Gly Lys Thr Gly Ile Gln Gln Leu Gln 
        755                 760                 765             


Lys Trp Glu Asp Trp Val Arg Trp Ile Gly Asn Ile Pro Gln Tyr Leu 
    770                 775                 780                 


Lys Gly Leu Leu Gly Gly Ile Leu Gly Ile Gly Leu Gly Val Leu Leu 
785                 790                 795                 800 


Leu Ile Leu Cys Leu Pro Thr Leu Val Asp Cys Ile Arg Asn Cys Ile 
                805                 810                 815     


His Lys Ile Leu Gly Tyr Thr Val Ile Ala Met Pro Glu Val Glu Gly 
            820                 825                 830         


Glu Glu Ile Gln Pro Gln Met Glu Leu Arg Arg Asn Gly Arg Gln Cys 
        835                 840                 845             


Gly Met Ser Glu Lys Glu Glu Glu 
    850                 855     


<210>  342
<211>  855
<212>  PRT
<213>  Artificial sequence

<220>
<223>  Mutated sequence

<400>  342

Met Ala Glu Gly Phe Ala Ala Asn Arg Gln Trp Ile Gly Pro Glu Glu 
1               5                   10                  15      


Ala Glu Glu Leu Leu Asp Phe Asp Ile Ala Thr Gln Met Ser Glu Glu 
            20                  25                  30          


Gly Pro Leu Asn Pro Gly Val Asn Pro Phe Arg Val Pro Gly Ile Thr 
        35                  40                  45              


Glu Lys Glu Lys Gln Asn Tyr Cys Asn Ile Leu Gln Pro Lys Leu Gln 
    50                  55                  60                  


Asp Leu Arg Asn Glu Ile Gln Glu Val Lys Leu Glu Glu Gly Asn Ala 
65                  70                  75                  80  


Gly Lys Phe Arg Arg Ala Arg Phe Leu Arg Tyr Ser Asp Glu Arg Val 
                85                  90                  95      


Leu Ser Leu Val His Ala Phe Ile Gly Tyr Cys Ile Tyr Leu Gly Asn 
            100                 105                 110         


Arg Asn Lys Leu Gly Ser Leu Arg His Asp Ile Asp Ile Glu Ala Pro 
        115                 120                 125             


Gln Glu Glu Cys Tyr Asn Asn Arg Glu Lys Gly Thr Thr Asp Asn Ile 
    130                 135                 140                 


Lys Tyr Gly Arg Arg Cys Cys Leu Gly Thr Val Thr Leu Tyr Leu Ile 
145                 150                 155                 160 


Leu Phe Thr Gly Val Ile Val Tyr Ser Gln Thr Ala Gly Ala Gln Val 
                165                 170                 175     


Val Trp Arg Leu Pro Pro Leu Val Val Pro Val Glu Glu Ser Glu Ile 
            180                 185                 190         


Ile Phe Trp Asp Cys Trp Ala Pro Glu Glu Pro Ala Cys Gln Asp Phe 
        195                 200                 205             


Leu Gly Ala Met Ile His Leu Lys Ala Lys Thr Asn Ile Ser Ile Arg 
    210                 215                 220                 


Glu Gly Pro Thr Leu Gly Asn Trp Ala Arg Glu Ile Trp Ala Thr Leu 
225                 230                 235                 240 


Phe Lys Lys Ala Thr Arg Gln Cys Arg Arg Gly Arg Ile Trp Lys Arg 
                245                 250                 255     


Trp Asn Glu Thr Ile Thr Gly Pro Ser Gly Cys Ala Asn Asn Thr Cys 
            260                 265                 270         


Tyr Asn Val Ser Val Ile Val Pro Asp Tyr Gln Cys Tyr Leu Asp Arg 
        275                 280                 285             


Val Asp Thr Trp Leu Gln Gly Lys Ile Asn Ile Ser Leu Cys Leu Thr 
    290                 295                 300                 


Gly Gly Lys Met Leu Tyr Asn Lys Val Thr Lys Gln Leu Ser Tyr Cys 
305                 310                 315                 320 


Thr Asp Pro Leu Gln Ile Pro Leu Ile Asn Tyr Thr Phe Gly Pro Asn 
                325                 330                 335     


Gln Thr Cys Met Trp Asn Thr Ser Gln Ile Gln Asp Pro Glu Ile Pro 
            340                 345                 350         


Lys Cys Gly Trp Trp Asn Gln Met Ala Tyr Tyr Asn Ser Cys Lys Trp 
        355                 360                 365             


Glu Glu Ala Lys Val Lys Phe His Cys Gln Arg Thr Gln Ser Gln Pro 
    370                 375                 380                 


Gly Ser Trp Phe Arg Ala Ile Ser Ser Trp Lys Gln Arg Asn Arg Trp 
385                 390                 395                 400 


Glu Trp Arg Pro Asp Phe Lys Ser Lys Lys Val Lys Ile Ser Leu Pro 
                405                 410                 415     


Cys Asn Ser Thr Lys Asn Leu Thr Phe Ala Met Arg Ser Ser Gly Asp 
            420                 425                 430         


Tyr Gly Glu Val Thr Gly Ala Trp Ile Glu Phe Gly Cys His Arg Asn 
        435                 440                 445             


Lys Ser Asn Leu His Thr Glu Ala Arg Phe Arg Ile Arg Cys Arg Trp 
    450                 455                 460                 


Asn Val Gly Ser Asp Thr Ser Leu Ile Asp Thr Cys Gly Asn Thr Pro 
465                 470                 475                 480 


Asn Val Ser Gly Ala Asn Pro Val Asp Cys Thr Met Tyr Ser Asn Lys 
                485                 490                 495     


Met Tyr Asn Cys Ser Leu Gln Asn Gly Phe Thr Met Lys Val Asp Asp 
            500                 505                 510         


Leu Ile Val His Phe Asn Met Thr Lys Ala Val Glu Met Tyr Asn Ile 
        515                 520                 525             


Ala Gly Asn Trp Ser Cys Thr Ser Asp Leu Pro Ser Ser Trp Gly Tyr 
    530                 535                 540                 


Met Asn Cys Asn Cys Thr Asn Ser Ser Ser Ser Tyr Ser Gly Thr Lys 
545                 550                 555                 560 


Met Ala Cys Pro Ser Asn Arg Gly Ile Leu Arg Asn Trp Tyr Asn Pro 
                565                 570                 575     


Val Ala Gly Leu Arg Gln Ser Leu Glu Gln Tyr Gln Val Val Lys Gln 
            580                 585                 590         


Pro Asp Tyr Leu Leu Val Pro Glu Glu Val Met Glu Tyr Lys Pro Arg 
        595                 600                 605             


Arg Lys Arg Ala Ala Ile His Val Met Leu Ala Leu Ala Thr Val Leu 
    610                 615                 620                 


Ser Ile Ala Gly Ala Gly Thr Gly Ala Thr Ala Ile Gly Met Val Thr 
625                 630                 635                 640 


Gln Tyr His Gln Val Leu Ala Thr His Gln Glu Ala Ile Glu Lys Val 
                645                 650                 655     


Thr Gly Ala Leu Lys Ile Asn Asn Leu Arg Leu Val Thr Leu Glu His 
            660                 665                 670         


Gln Val Leu Val Ile Gly Leu Lys Val Glu Ala Met Glu Lys Arg Phe 
        675                 680                 685             


Tyr Thr Ala Phe Ala Met Gln Glu Leu Gly Cys Asn Gln Asn Gln Phe 
    690                 695                 700                 


Phe Cys Lys Ile Pro Leu Glu Leu Trp Thr Arg Tyr Asn Met Thr Ile 
705                 710                 715                 720 


Asn Gln Thr Ile Trp Asn His Gly Asn Ile Thr Leu Gly Glu Trp Tyr 
                725                 730                 735     


Asn Gln Thr Lys Asp Leu Gln Gln Lys Phe Tyr Glu Ile Ile Met Asp 
            740                 745                 750         


Ile Glu Gln Asn Asn Val Gln Gly Lys Thr Gly Ile Gln Gln Leu Gln 
        755                 760                 765             


Lys Trp Glu Asp Trp Val Arg Trp Ile Gly Asn Ile Pro Gln Tyr Leu 
    770                 775                 780                 


Lys Gly Leu Leu Gly Gly Ile Leu Gly Ile Gly Leu Gly Val Leu Leu 
785                 790                 795                 800 


Leu Ile Leu Cys Leu Pro Thr Leu Val Asp Cys Ile Arg Asn Cys Ile 
                805                 810                 815     


His Lys Ile Leu Gly Tyr Thr Val Ile Ala Met Pro Glu Val Glu Gly 
            820                 825                 830         


Glu Glu Ile Gln Pro Gln Met Glu Leu Arg Arg Asn Gly Arg Gln Cys 
        835                 840                 845             


Gly Met Ser Glu Lys Glu Glu 
    850                 855 


<210>  343
<211>  9
<212>  PRT
<213>  FIV


<220>
<221>  MISC_FEATURE
<222>  (2)..(2)
<223>  Xaa is Ile or Met or Thr or Leu

<400>  343

Ala Xaa Glu Lys Phe Leu Tyr Thr Ala 
1               5                   


<210>  344
<211>  9
<212>  PRT
<213>  FIV


<220>
<221>  MISC_FEATURE
<222>  (2)..(2)
<223>  Xaa is Ile or Met or Thr or leu

<220>
<221>  MISC_FEATURE
<222>  (3)..(3)
<223>  Xaa is Ser or Thr or Asn or Gln or Glu or Asp or Lys or His or 
       Met or Cys or Trp or Tyr or Val or Ile or Pro

<220>
<221>  MISC_FEATURE
<222>  (4)..(4)
<223>  Xaa is Ser or Thr or Asn or Gln or Glu or Asp or Lys or His or 
       Met or Cys or Trp or Tyr or Val or Ile or Pro

<220>
<221>  MISC_FEATURE
<222>  (5)..(5)
<223>  Xaa is Ser or Thr or Asn or Gln or Glu or Asp or Lys or His or 
       Met or Cys or Trp or Tyr or Val or Ile or Pro or Phe

<220>
<221>  MISC_FEATURE
<222>  (6)..(6)
<223>  Xaa is Ser or Thr or Asn or Gln or Glu or Asp or Lys or His or 
       Met or Cys or Trp or Tyr or Val or Ile or Pro or Leu

<220>
<221>  MISC_FEATURE
<222>  (7)..(7)
<223>  Xaa is Ser or Thr or Asn or Gln or Glu or Asp or Lys or His or 
       Met or Cys or Trp or Tyr or Val or Ile or Pro

<400>  344

Ala Xaa Xaa Xaa Xaa Xaa Xaa Thr Ala 
1               5                   


<210>  345
<211>  14
<212>  PRT
<213>  FIV


<220>
<221>  MISC_FEATURE
<222>  (1)..(1)
<223>  Xaa is Val or Ile

<220>
<221>  MISC_FEATURE
<222>  (2)..(2)
<223>  Xaa is Glu or Arg

<220>
<221>  MISC_FEATURE
<222>  (4)..(4)
<223>  Xaa is Ile or Met or Thr or Leu

<220>
<221>  MISC_FEATURE
<222>  (5)..(5)
<223>  Xaa is Ser or Thr or Asn or Gln or Glu or Asp or Lys or His or 
       Met or Cys or Trp or Tyr or Val or Ile or Pro

<220>
<221>  MISC_FEATURE
<222>  (6)..(6)
<223>  Xaa is Ser or Thr or Asn or Gln or Glu or Asp or Lys or His or 
       Met or Cys or Trp or Tyr or Val or Ile or Pro

<220>
<221>  MISC_FEATURE
<222>  (7)..(7)
<223>  Xaa is Ser or Thr or Asn or Gln or Glu or Asp or Lys or His or 
       Met or Cys or Trp or Tyr or Val or Ile or Pro or Phe

<220>
<221>  MISC_FEATURE
<222>  (8)..(8)
<223>  Xaa is Ser or Thr or Asn or Gln or Glu or Asp or Lys or His or 
       Met or Cys or Trp or Tyr or Val or Ile or Pro or Leu

<220>
<221>  MISC_FEATURE
<222>  (9)..(9)
<223>  Xaa is Ser or Thr or Asn or Gln or Glu or Asp or Lys or His or 
       Met or Cys or Trp or Tyr or Val or Ile or Pro

<220>
<221>  MISC_FEATURE
<222>  (12)..(12)
<223>  Xaa is Phe or Leu

<400>  345

Xaa Xaa Ala Xaa Xaa Xaa Xaa Xaa Xaa Thr Ala Xaa Ala Met 
1               5                   10                  


<210>  346
<211>  9
<212>  PRT
<213>  FIV


<220>
<221>  MISC_FEATURE
<222>  (2)..(2)
<223>  Xaa is Ile or Met or Thr or Val

<220>
<221>  MISC_FEATURE
<222>  (5)..(5)
<223>  Xaa is Phe or Pro

<220>
<221>  MISC_FEATURE
<222>  (6)..(6)
<223>  Xaa is Leu or Val or Ile

<400>  346

Ala Xaa Glu Lys Xaa Xaa Tyr Thr Ala 
1               5                   


<210>  347
<211>  14
<212>  PRT
<213>  FIV


<220>
<221>  MISC_FEATURE
<222>  (1)..(1)
<223>  Xaa is Val or Ile

<220>
<221>  MISC_FEATURE
<222>  (2)..(2)
<223>  Xaa is Glu or Arg

<220>
<221>  MISC_FEATURE
<222>  (4)..(4)
<223>  Xaa is Ile or Met or Thr or Leu

<220>
<221>  MISC_FEATURE
<222>  (7)..(7)
<223>  Xaa is Phe or Pro

<220>
<221>  MISC_FEATURE
<222>  (8)..(8)
<223>  Xaa is Leu or Val or Ile

<220>
<221>  MISC_FEATURE
<222>  (12)..(12)
<223>  Xaa is Phe or Leu

<400>  347

Xaa Xaa Ala Xaa Glu Lys Xaa Xaa Tyr Thr Ala Xaa Ala Met 
1               5                   10                  


<210>  348
<211>  51
<212>  DNA
<213>  Artificial sequence

<220>
<223>  oligonucleotide for introducing mutation within the ISU of 
       lentiviral protein

<400>  348
atacatctcg agaccggtcc aactagaacc atggcagaag gatttgcagc c                51


<210>  349
<211>  41
<212>  DNA
<213>  Artificial sequence

<220>
<223>  oligonucleotide for introducing mutation within the ISU of 
       lentiviral protein

<400>  349
atacatacgc gttcattcct cctctttttc agacatgcca c                           41


<210>  350
<211>  35
<212>  DNA
<213>  Artificial sequence

<220>
<223>  oligonucleotide for introducing mutation within the ISU of 
       lentiviral protein

<400>  350
tactgctata gggatggtaa cacaatacca ccaag                                  35


<210>  351
<211>  40
<212>  DNA
<213>  Artificial sequence

<220>
<223>  oligonucleotide for introducing mutation within the ISU of 
       lentiviral protein

<400>  351
gattaaaagt agaagctatg gcaaaatttt tgtatacagc                             40


<210>  352
<211>  40
<212>  DNA
<213>  Artificial sequence

<220>
<223>  oligonucleotide for introducing mutation within the ISU of 
       lentiviral protein

<400>  352
gctgtataca aaaattttgc catagcttct acttttaatc                             40


<210>  353
<211>  40
<212>  DNA
<213>  Artificial sequence

<220>
<223>  oligonucleotide for introducing mutation within the ISU of 
       lentiviral protein

<400>  353
gattaaaagt agaagctatg agaaaatttt tgtatacagc                             40


<210>  354
<211>  40
<212>  DNA
<213>  Artificial sequence

<220>
<223>  oligonucleotide for introducing mutation within the ISU of 
       lentiviral protein

<400>  354
gctgtataca aaaattttct catagcttct acttttaatc                             40


<210>  355
<211>  36
<212>  DNA
<213>  Artificial sequence

<220>
<223>  oligonucleotide for introducing mutation within the ISU of 
       lentiviral protein

<400>  355
gtagaagcta tggaagcatt tttgtataca gctttc                                 36


<210>  356
<211>  36
<212>  DNA
<213>  Artificial sequence

<220>
<223>  oligonucleotide for introducing mutation within the ISU of 
       lentiviral protein

<400>  356
gaaagctgta tacaaaaatg cttccatagc ttctac                                 36


<210>  357
<211>  36
<212>  DNA
<213>  Artificial sequence

<220>
<223>  oligonucleotide for introducing mutation within the ISU of 
       lentiviral protein

<400>  357
gtagaagcta tggaaagatt tttgtataca gctttc                                 36


<210>  358
<211>  36
<212>  DNA
<213>  Artificial sequence

<220>
<223>  oligonucleotide for introducing mutation within the ISU of 
       lentiviral protein

<400>  358
gaaagctgta tacaaaaatc tttccatagc ttctac                                 36


<210>  359
<211>  33
<212>  DNA
<213>  Artificial sequence

<220>
<223>  oligonucleotide for introducing mutation within the ISU of 
       lentiviral protein

<400>  359
gaagctatgg aaaaagcctt gtatacagct ttc                                    33


<210>  360
<211>  33
<212>  DNA
<213>  Artificial sequence

<220>
<223>  oligonucleotide for introducing mutation within the ISU of 
       lentiviral protein

<400>  360
gaaagctgta tacaaggctt tttccatagc ttc                                    33


<210>  361
<211>  33
<212>  DNA
<213>  Artificial sequence

<220>
<223>  Mutated sequence

<400>  361
gaagctatgg aaaaaagatt gtatacagct ttc                                    33


<210>  362
<211>  33
<212>  DNA
<213>  Artificial sequence

<220>
<223>  oligonucleotide for introducing mutation within the ISU of 
       lentiviral protein

<400>  362
gaaagctgta tacaatcttt tttccatagc ttc                                    33


<210>  363
<211>  36
<212>  DNA
<213>  Artificial sequence

<220>
<223>  oligonucleotide for introducing mutation within the ISU of 
       lentiviral protein

<400>  363
gctatggaaa aatttgccta tacagctttc gctatg                                 36


<210>  364
<211>  36
<212>  DNA
<213>  Artificial sequence

<220>
<223>  oligonucleotide for introducing mutation within the ISU of 
       lentiviral protein

<400>  364
catagcgaaa gctgtatagg caaatttttc catagc                                 36


<210>  365
<211>  36
<212>  DNA
<213>  Artificial sequence

<220>
<223>  oligonucleotide for introducing mutation within the ISU of 
       lentiviral protein

<400>  365
gctatggaaa aatttaggta tacagctttc gctatg                                 36


<210>  366
<211>  36
<212>  DNA
<213>  Artificial sequence

<220>
<223>  oligonucleotide for introducing mutation within the ISU of 
       lentiviral protein

<400>  366
catagcgaaa gctgtatacc taaatttttc catagc                                 36


<210>  367
<211>  36
<212>  DNA
<213>  Artificial sequence

<220>
<223>  oligonucleotide for introducing mutation within the ISU of 
       lentiviral protein

<400>  367
ctatggaaaa atttttggcc acagctttcg ctatgc                                 36


<210>  368
<211>  36
<212>  DNA
<213>  Artificial sequence

<220>
<223>  oligonucleotide for introducing mutation within the ISU of 
       lentiviral protein

<400>  368
gcatagcgaa agctgtggcc aaaaattttt ccatag                                 36


<210>  369
<211>  36
<212>  DNA
<213>  Artificial sequence

<220>
<223>  oligonucleotide for introducing mutation within the ISU of 
       lentiviral protein

<400>  369
ctatggaaaa atttttgcgg acagctttcg ctatgc                                 36


<210>  370
<211>  36
<212>  DNA
<213>  Artificial sequence

<220>
<223>  oligonucleotide for introducing mutation within the ISU of 
       lentiviral protein

<400>  370
gcatagcgaa agctgtccgc aaaaattttt ccatag                                 36


<210>  371
<211>  45
<212>  DNA
<213>  Artificial sequence

<220>
<223>  oligonucleotide for introducing mutation within the ISU of 
       lentiviral protein

<400>  371
ggtgacgcgg cccagccggc cgctatagaa aaggtgactg gagcc                       45


<210>  372
<211>  36
<212>  DNA
<213>  Artificial sequence

<220>
<223>  oligonucleotide for introducing mutation within the ISU of 
       lentiviral protein

<400>  372
atacatacgc gtttaccttg tccacaactc aagagg                                 36


<210>  373
<211>  42
<212>  DNA
<213>  Artificial sequence

<220>
<223>  oligonucleotide for introducing mutation within the ISU of 
       lentiviral protein

<400>  373
atacatacgc gtttaccctg ttttcccttg tacattattt tg                          42


<210>  374
<211>  856
<212>  PRT
<213>  Artificial sequence

<220>
<223>  Mutated sequence

<400>  374

Met Ala Glu Gly Phe Ala Ala Asn Arg Gln Trp Ile Gly Leu Glu Glu 
1               5                   10                  15      


Ala Glu Glu Leu Leu Asp Phe Asp Ile Ala Thr Gln Met Ser Glu Glu 
            20                  25                  30          


Gly Pro Leu Asn Pro Gly Val Asn Pro Phe Arg Val Pro Gly Ile Thr 
        35                  40                  45              


Glu Lys Glu Lys Gln Asn Tyr Cys Asn Ile Leu Gln Pro Lys Leu Gln 
    50                  55                  60                  


Asp Leu Arg Asn Glu Ile Gln Glu Val Lys Leu Glu Glu Gly Asn Ala 
65                  70                  75                  80  


Gly Lys Phe Arg Arg Ala Arg Phe Leu Arg Tyr Ser Asp Glu Ser Val 
                85                  90                  95      


Leu Ser Leu Val His Ala Phe Ile Gly Tyr Cys Ile Tyr Leu Gly Asn 
            100                 105                 110         


Arg Asn Lys Leu Gly Ser Leu Arg His Asp Ile Asp Ile Glu Ala Pro 
        115                 120                 125             


Gln Glu Glu Cys Tyr Asn Asn Arg Glu Lys Gly Thr Thr Asp Asn Ile 
    130                 135                 140                 


Lys Tyr Gly Arg Arg Cys Cys Leu Gly Thr Val Thr Leu Tyr Leu Ile 
145                 150                 155                 160 


Leu Phe Ile Gly Ile Ile Ile Tyr Ser Gln Thr Thr Asn Ala Gln Val 
                165                 170                 175     


Val Trp Arg Leu Pro Pro Leu Val Val Pro Val Glu Glu Ser Glu Ile 
            180                 185                 190         


Ile Phe Trp Asp Cys Trp Ala Pro Glu Glu Pro Ala Cys Gln Asp Phe 
        195                 200                 205             


Leu Gly Ala Met Ile His Leu Lys Ala Lys Thr Asn Ile Ser Ile Arg 
    210                 215                 220                 


Glu Gly Pro Thr Leu Gly Asn Trp Ala Arg Glu Ile Trp Ala Thr Leu 
225                 230                 235                 240 


Phe Lys Lys Ala Thr Arg Gln Cys Arg Arg Gly Arg Ile Trp Lys Arg 
                245                 250                 255     


Trp Asn Glu Thr Ile Thr Gly Pro Ser Gly Cys Ala Asn Asn Thr Cys 
            260                 265                 270         


Tyr Asn Val Ser Val Ile Val Pro Asp Tyr Gln Cys Tyr Leu Asp Arg 
        275                 280                 285             


Val Asp Thr Trp Leu Gln Gly Lys Ile Asn Ile Ser Leu Cys Leu Thr 
    290                 295                 300                 


Gly Gly Lys Met Leu Tyr Asn Lys Val Thr Lys Gln Leu Ser Tyr Cys 
305                 310                 315                 320 


Thr Asp Pro Leu Gln Ile Pro Leu Ile Asn Tyr Thr Phe Gly Pro Asn 
                325                 330                 335     


Gln Thr Cys Met Trp Asn Thr Ser Gln Ile Gln Asp Pro Glu Ile Pro 
            340                 345                 350         


Lys Cys Gly Trp Trp Asn Gln Met Ala Tyr Tyr Asn Ser Cys Lys Trp 
        355                 360                 365             


Glu Glu Ala Lys Val Lys Phe His Cys Gln Arg Thr Gln Ser Gln Pro 
    370                 375                 380                 


Gly Ser Trp Phe Arg Ala Ile Ser Ser Trp Lys Gln Arg Asn Arg Trp 
385                 390                 395                 400 


Glu Trp Arg Pro Asp Phe Glu Ser Lys Lys Val Lys Ile Ser Leu Gln 
                405                 410                 415     


Cys Asn Ser Thr Lys Asn Leu Thr Phe Ala Met Arg Ser Ser Gly Asp 
            420                 425                 430         


Tyr Gly Glu Val Thr Gly Ala Trp Ile Glu Phe Gly Cys His Arg Asn 
        435                 440                 445             


Lys Ser Lys Leu His Ala Glu Ala Arg Phe Arg Ile Arg Cys Arg Trp 
    450                 455                 460                 


Asn Val Gly Ser Asn Thr Ser Leu Ile Asp Thr Cys Gly Asn Thr Gln 
465                 470                 475                 480 


Lys Val Ser Gly Ala Asn Pro Val Asp Cys Thr Met Tyr Ser Asn Lys 
                485                 490                 495     


Met Tyr Asn Cys Ser Leu Gln Asn Gly Phe Thr Met Lys Val Asp Asp 
            500                 505                 510         


Leu Ile Met His Phe Asn Met Lys Lys Ala Val Glu Met Tyr Asn Ile 
        515                 520                 525             


Ala Gly Asn Trp Ser Cys Thr Ser Asp Leu Pro Ser Ser Trp Gly Tyr 
    530                 535                 540                 


Met Asn Cys Asn Cys Thr Asn Ser Ser Ser Ser Tyr Ser Gly Thr Lys 
545                 550                 555                 560 


Met Ala Cys Pro Ser Asn Arg Gly Ile Leu Arg Asn Trp Tyr Asn Pro 
                565                 570                 575     


Val Ala Gly Leu Arg Gln Ser Leu Glu Gln Tyr Gln Val Val Lys Gln 
            580                 585                 590         


Pro Asp Tyr Leu Val Val Pro Glu Glu Val Met Glu Tyr Lys Pro Arg 
        595                 600                 605             


Arg Lys Arg Ala Ala Ile His Val Met Leu Ala Leu Ala Ala Val Leu 
    610                 615                 620                 


Ser Ile Ala Gly Ala Gly Thr Gly Ala Thr Ala Ile Gly Met Val Thr 
625                 630                 635                 640 


Gln Tyr His Gln Val Leu Ala Thr His Gln Glu Ala Val Glu Lys Val 
                645                 650                 655     


Thr Glu Ala Leu Lys Ile Asn Asn Leu Arg Leu Val Thr Leu Glu His 
            660                 665                 670         


Gln Val Leu Val Ile Gly Leu Lys Val Glu Ala Met Glu Lys Arg Leu 
        675                 680                 685             


Tyr Thr Ala Phe Ala Met Gln Glu Leu Gly Cys Asn Gln Asn Gln Phe 
    690                 695                 700                 


Phe Cys Lys Ile Pro Pro Glu Leu Trp Thr Arg Tyr Asn Met Thr Ile 
705                 710                 715                 720 


Asn Gln Thr Ile Trp Asn His Gly Asn Ile Thr Leu Gly Glu Trp Tyr 
                725                 730                 735     


Asn Gln Thr Lys Asp Leu Gln Gln Lys Phe Tyr Glu Ile Ile Met Asp 
            740                 745                 750         


Ile Glu Gln Asn Asn Val Gln Gly Lys Lys Gly Ile Gln Gln Leu Gln 
        755                 760                 765             


Lys Trp Glu Asp Trp Val Gly Trp Ile Gly Asn Ile Pro Gln Tyr Leu 
    770                 775                 780                 


Lys Gly Leu Leu Gly Gly Ile Leu Gly Ile Gly Leu Gly Val Leu Leu 
785                 790                 795                 800 


Leu Ile Leu Cys Leu Pro Thr Leu Val Asp Cys Ile Arg Asn Cys Ile 
                805                 810                 815     


His Lys Ile Leu Gly Tyr Thr Val Ile Ala Met Pro Glu Val Glu Gly 
            820                 825                 830         


Glu Glu Ile Gln Pro Gln Met Glu Leu Arg Arg Asn Gly Arg Gln Cys 
        835                 840                 845             


Gly Met Ser Glu Lys Glu Glu Glu 
    850                 855     


<210>  375
<211>  856
<212>  PRT
<213>  Artificial sequence

<220>
<223>  Mutated sequence

<400>  375

Met Ala Glu Gly Phe Ala Ala Asn Arg Gln Trp Ile Gly Leu Glu Glu 
1               5                   10                  15      


Ala Glu Glu Leu Leu Asp Phe Asp Ile Ala Thr Gln Met Ser Glu Glu 
            20                  25                  30          


Gly Pro Leu Asn Pro Gly Val Asn Pro Phe Arg Val Pro Gly Ile Thr 
        35                  40                  45              


Glu Lys Glu Lys Gln Asn Tyr Cys Asn Ile Leu Gln Pro Lys Leu Gln 
    50                  55                  60                  


Asp Leu Arg Asn Glu Ile Gln Glu Val Lys Leu Glu Glu Gly Asn Ala 
65                  70                  75                  80  


Gly Lys Phe Arg Arg Ala Arg Phe Leu Arg Tyr Ser Asp Glu Ser Val 
                85                  90                  95      


Leu Ser Leu Val His Ala Phe Ile Gly Tyr Cys Ile Tyr Leu Gly Asn 
            100                 105                 110         


Arg Asn Lys Leu Gly Ser Leu Arg His Asp Ile Asp Ile Glu Ala Pro 
        115                 120                 125             


Gln Glu Glu Cys Tyr Asn Asn Arg Glu Lys Gly Thr Thr Asp Asn Ile 
    130                 135                 140                 


Lys Tyr Gly Arg Arg Cys Cys Leu Gly Thr Val Thr Leu Tyr Leu Ile 
145                 150                 155                 160 


Leu Phe Ile Gly Ile Ile Ile Tyr Ser Gln Thr Thr Asn Ala Gln Val 
                165                 170                 175     


Val Trp Arg Leu Pro Pro Leu Val Val Pro Val Glu Glu Ser Glu Ile 
            180                 185                 190         


Ile Phe Trp Asp Cys Trp Ala Pro Glu Glu Pro Ala Cys Gln Asp Phe 
        195                 200                 205             


Leu Gly Ala Met Ile His Leu Lys Ala Lys Thr Asn Ile Ser Ile Arg 
    210                 215                 220                 


Glu Gly Pro Thr Leu Gly Asn Trp Ala Arg Glu Ile Trp Ala Thr Leu 
225                 230                 235                 240 


Phe Lys Lys Ala Thr Arg Gln Cys Arg Arg Gly Arg Ile Trp Lys Arg 
                245                 250                 255     


Trp Asn Glu Thr Ile Thr Gly Pro Ser Gly Cys Ala Asn Asn Thr Cys 
            260                 265                 270         


Tyr Asn Val Ser Val Ile Val Pro Asp Tyr Gln Cys Tyr Leu Asp Arg 
        275                 280                 285             


Val Asp Thr Trp Leu Gln Gly Lys Ile Asn Ile Ser Leu Cys Leu Thr 
    290                 295                 300                 


Gly Gly Lys Met Leu Tyr Asn Lys Val Thr Lys Gln Leu Ser Tyr Cys 
305                 310                 315                 320 


Thr Asp Pro Leu Gln Ile Pro Leu Ile Asn Tyr Thr Phe Gly Pro Asn 
                325                 330                 335     


Gln Thr Cys Met Trp Asn Thr Ser Gln Ile Gln Asp Pro Glu Ile Pro 
            340                 345                 350         


Lys Cys Gly Trp Trp Asn Gln Met Ala Tyr Tyr Asn Ser Cys Lys Trp 
        355                 360                 365             


Glu Glu Ala Lys Val Lys Phe His Cys Gln Arg Thr Gln Ser Gln Pro 
    370                 375                 380                 


Gly Ser Trp Phe Arg Ala Ile Ser Ser Trp Lys Gln Arg Asn Arg Trp 
385                 390                 395                 400 


Glu Trp Arg Pro Asp Phe Glu Ser Lys Lys Val Lys Ile Ser Leu Gln 
                405                 410                 415     


Cys Asn Ser Thr Lys Asn Leu Thr Phe Ala Met Arg Ser Ser Gly Asp 
            420                 425                 430         


Tyr Gly Glu Val Thr Gly Ala Trp Ile Glu Phe Gly Cys His Arg Asn 
        435                 440                 445             


Lys Ser Lys Leu His Ala Glu Ala Arg Phe Arg Ile Arg Cys Arg Trp 
    450                 455                 460                 


Asn Val Gly Ser Asn Thr Ser Leu Ile Asp Thr Cys Gly Asn Thr Gln 
465                 470                 475                 480 


Lys Val Ser Gly Ala Asn Pro Val Asp Cys Thr Met Tyr Ser Asn Lys 
                485                 490                 495     


Met Tyr Asn Cys Ser Leu Gln Asn Gly Phe Thr Met Lys Val Asp Asp 
            500                 505                 510         


Leu Ile Met His Phe Asn Met Lys Lys Ala Val Glu Met Tyr Asn Ile 
        515                 520                 525             


Ala Gly Asn Trp Ser Cys Thr Ser Asp Leu Pro Ser Ser Trp Gly Tyr 
    530                 535                 540                 


Met Asn Cys Asn Cys Thr Asn Ser Ser Ser Ser Tyr Ser Gly Thr Lys 
545                 550                 555                 560 


Met Ala Cys Pro Ser Asn Arg Gly Ile Leu Arg Asn Trp Tyr Asn Pro 
                565                 570                 575     


Val Ala Gly Leu Arg Gln Ser Leu Glu Gln Tyr Gln Val Val Lys Gln 
            580                 585                 590         


Pro Asp Tyr Leu Val Val Pro Glu Glu Val Met Glu Tyr Lys Pro Arg 
        595                 600                 605             


Arg Lys Arg Ala Ala Ile His Val Met Leu Ala Leu Ala Ala Val Leu 
    610                 615                 620                 


Ser Ile Ala Gly Ala Gly Thr Gly Ala Thr Ala Ile Gly Met Val Thr 
625                 630                 635                 640 


Gln Tyr His Gln Val Leu Ala Thr His Gln Glu Ala Val Glu Lys Val 
                645                 650                 655     


Thr Glu Ala Leu Lys Ile Asn Asn Leu Arg Leu Val Thr Leu Glu His 
            660                 665                 670         


Gln Val Leu Val Ile Gly Leu Lys Val Glu Ala Met Glu Lys Phe Arg 
        675                 680                 685             


Tyr Thr Ala Phe Ala Met Gln Glu Leu Gly Cys Asn Gln Asn Gln Phe 
    690                 695                 700                 


Phe Cys Lys Ile Pro Pro Glu Leu Trp Thr Arg Tyr Asn Met Thr Ile 
705                 710                 715                 720 


Asn Gln Thr Ile Trp Asn His Gly Asn Ile Thr Leu Gly Glu Trp Tyr 
                725                 730                 735     


Asn Gln Thr Lys Asp Leu Gln Gln Lys Phe Tyr Glu Ile Ile Met Asp 
            740                 745                 750         


Ile Glu Gln Asn Asn Val Gln Gly Lys Lys Gly Ile Gln Gln Leu Gln 
        755                 760                 765             


Lys Trp Glu Asp Trp Val Gly Trp Ile Gly Asn Ile Pro Gln Tyr Leu 
    770                 775                 780                 


Lys Gly Leu Leu Gly Gly Ile Leu Gly Ile Gly Leu Gly Val Leu Leu 
785                 790                 795                 800 


Leu Ile Leu Cys Leu Pro Thr Leu Val Asp Cys Ile Arg Asn Cys Ile 
                805                 810                 815     


His Lys Ile Leu Gly Tyr Thr Val Ile Ala Met Pro Glu Val Glu Gly 
            820                 825                 830         


Glu Glu Ile Gln Pro Gln Met Glu Leu Arg Arg Asn Gly Arg Gln Cys 
        835                 840                 845             


Gly Met Ser Glu Lys Glu Glu Glu 
    850                 855     


<210>  376
<211>  856
<212>  PRT
<213>  Artificial sequence

<220>
<223>  Mutated sequence

<400>  376

Met Ala Glu Gly Phe Val Ala Asn Gly Gln Trp Ile Gly Pro Glu Glu 
1               5                   10                  15      


Ala Glu Glu Leu Val Asp Phe Glu Ile Ala Thr Gln Met Asn Glu Glu 
            20                  25                  30          


Gly Pro Leu Asn Pro Gly Ile Asn Pro Phe Arg Val Pro Gly Ile Thr 
        35                  40                  45              


Lys Gln Glu Lys Gln Glu Tyr Cys Ser Thr Met Gln Pro Lys Leu Gln 
    50                  55                  60                  


Ala Leu Arg Asn Glu Ile Gln Glu Val Lys Leu Glu Glu Gly Asn Ala 
65                  70                  75                  80  


Gly Lys Phe Arg Arg Ala Arg Phe Leu Arg Tyr Ser Asp Glu Thr Ile 
                85                  90                  95      


Leu Ser Leu Ile Tyr Leu Phe Ile Gly Tyr Phe Arg Tyr Leu Val Asp 
            100                 105                 110         


Arg Lys Arg Phe Gly Ser Leu Arg His Asp Ile Asp Ile Glu Ala Pro 
        115                 120                 125             


Gln Glu Glu Cys Tyr Asn Asn Lys Glu Lys Gly Met Thr Glu Asn Ile 
    130                 135                 140                 


Lys Tyr Gly Lys Arg Cys Leu Val Gly Thr Ala Ala Leu Tyr Leu Ile 
145                 150                 155                 160 


Leu Ala Ile Gly Ile Ile Ile Ile Ile Arg Thr Thr Asp Ala Gln Val 
                165                 170                 175     


Val Trp Arg Leu Pro Pro Leu Val Val Pro Val Glu Glu Ser Glu Ile 
            180                 185                 190         


Ile Phe Trp Asp Cys Trp Ala Pro Glu Glu Pro Ala Cys Gln Asp Phe 
        195                 200                 205             


Leu Gly Ala Met Ile His Leu Lys Ala Ser Thr Asn Ile Ser Asn Thr 
    210                 215                 220                 


Glu Gly Pro Thr Leu Gly Asn Trp Ala Arg Glu Ile Trp Ala Thr Leu 
225                 230                 235                 240 


Phe Lys Lys Ala Thr Arg Gln Cys Arg Arg Gly Arg Ile Trp Lys Arg 
                245                 250                 255     


Trp Asn Glu Thr Ile Thr Gly Pro Ile Gly Cys Ala Asn Asn Thr Cys 
            260                 265                 270         


Tyr Asn Ile Ser Val Ile Val Pro Asp Tyr Gln Cys Tyr Ile Asp Arg 
        275                 280                 285             


Val Asp Thr Trp Leu Gln Gly Lys Val Asn Ile Ser Leu Cys Leu Thr 
    290                 295                 300                 


Gly Gly Lys Met Leu Tyr Asn Lys Glu Thr Lys Gln Leu Ser Tyr Cys 
305                 310                 315                 320 


Thr Asp Pro Leu Gln Ile Pro Leu Ile Asn Tyr Thr Phe Gly Pro Asn 
                325                 330                 335     


Gln Thr Cys Met Trp Asn Ile Ser Gln Ile Gln Asp Pro Glu Ile Pro 
            340                 345                 350         


Lys Cys Gly Trp Trp Asn Gln Gln Ala Tyr Tyr Asn Asn Cys Lys Trp 
        355                 360                 365             


Glu Arg Thr Asp Val Lys Phe Gln Cys Gln Arg Thr Gln Ser Gln Pro 
    370                 375                 380                 


Gly Ser Trp Ile Arg Ala Ile Ser Ser Trp Lys Gln Gly Asn Arg Trp 
385                 390                 395                 400 


Glu Trp Arg Pro Asp Phe Glu Ser Glu Arg Val Lys Val Ser Leu Gln 
                405                 410                 415     


Cys Asn Ser Thr Arg Asn Leu Thr Phe Ala Met Arg Ser Ser Gly Asp 
            420                 425                 430         


Tyr Gly Glu Ile Thr Gly Ala Trp Ile Glu Phe Gly Cys His Arg Asn 
        435                 440                 445             


Lys Ser Ile Arg His Asn Ala Ala Arg Phe Arg Ile Arg Cys Arg Trp 
    450                 455                 460                 


Asn Glu Gly Asp Asn Asn Ser Leu Ile Asp Thr Cys Gly Glu Thr Gln 
465                 470                 475                 480 


Asn Val Ser Gly Ala Asn Pro Val Asp Cys Thr Met Tyr Ala Asn Lys 
                485                 490                 495     


Met Tyr Asn Cys Ser Leu Gln Asp Gly Phe Thr Met Lys Val Asp Asp 
            500                 505                 510         


Leu Ile Met His Phe Asn Met Thr Lys Ala Val Glu Met Tyr Asn Ile 
        515                 520                 525             


Ala Gly Asn Trp Ser Cys Met Ser Asp Leu Pro Thr Glu Trp Gly Tyr 
    530                 535                 540                 


Met Asn Cys Asn Cys Thr Asn Asp Thr Ser Asn Asn Asn Thr Arg Lys 
545                 550                 555                 560 


Met Lys Cys Pro Lys Glu Asn Gly Ile Leu Arg Asn Trp Tyr Asn Pro 
                565                 570                 575     


Val Ala Gly Leu Arg Gln Ser Leu Glu Lys Tyr Gln Val Val Lys Gln 
            580                 585                 590         


Pro Asp Tyr Leu Leu Val Pro Glu Glu Val Met Glu Tyr Lys Pro Arg 
        595                 600                 605             


Arg Lys Arg Ala Ala Ile His Val Met Leu Ala Leu Ala Thr Val Leu 
    610                 615                 620                 


Ser Met Ala Gly Ala Gly Thr Gly Ala Thr Ala Ile Gly Met Val Thr 
625                 630                 635                 640 


Gln Tyr His Gln Val Leu Ala Thr Gln Gln Glu Ala Ile Glu Lys Val 
                645                 650                 655     


Thr Glu Ala Leu Lys Ile Thr Asn Leu Arg Leu Val Thr Leu Glu His 
            660                 665                 670         


Gln Val Leu Val Ile Gly Leu Lys Val Glu Ala Met Glu Lys Arg Leu 
        675                 680                 685             


Tyr Thr Ala Phe Ala Met Gln Glu Leu Gly Cys Asn Gln Asn Gln Phe 
    690                 695                 700                 


Phe Cys Lys Val Pro Pro Glu Leu Trp Arg Arg Tyr Asn Met Thr Ile 
705                 710                 715                 720 


Asn Gln Thr Ile Trp Asn His Gly Asn Ile Thr Leu Gly Glu Trp Tyr 
                725                 730                 735     


Asn Gln Thr Lys Asp Leu Gln Lys Lys Phe Tyr Gly Ile Ile Met Asp 
            740                 745                 750         


Ile Glu Gln Asn Asn Val Gln Gly Lys Lys Gly Leu Gln Gln Leu Gln 
        755                 760                 765             


Lys Trp Glu Asp Trp Val Gly Trp Ile Gly Asn Ile Pro Gln Tyr Leu 
    770                 775                 780                 


Lys Gly Leu Leu Gly Ser Ile Val Gly Ile Gly Leu Gly Ile Leu Leu 
785                 790                 795                 800 


Leu Ile Leu Cys Leu Pro Thr Leu Val Asp Cys Ile Arg Asn Cys Ile 
                805                 810                 815     


His Lys Ile Leu Gly Tyr Thr Val Ile Ala Met Pro Glu Val Asp Gly 
            820                 825                 830         


Glu Glu Ile Gln Pro Gln Met Glu Leu Arg Arg Asn Gly Arg Gln Cys 
        835                 840                 845             


Gly Met Ser Glu Lys Glu Glu Glu 
    850                 855     


<210>  377
<211>  856
<212>  PRT
<213>  Artificial sequence

<220>
<223>  Mutated sequence

<400>  377

Met Ala Glu Gly Phe Val Ala Asn Gly Gln Trp Ile Gly Pro Glu Glu 
1               5                   10                  15      


Ala Glu Glu Leu Val Asp Phe Glu Ile Ala Thr Gln Met Asn Glu Glu 
            20                  25                  30          


Gly Pro Leu Asn Pro Gly Ile Asn Pro Phe Arg Val Pro Gly Ile Thr 
        35                  40                  45              


Lys Gln Glu Lys Gln Glu Tyr Cys Ser Thr Met Gln Pro Lys Leu Gln 
    50                  55                  60                  


Ala Leu Arg Asn Glu Ile Gln Glu Val Lys Leu Glu Glu Gly Asn Ala 
65                  70                  75                  80  


Gly Lys Phe Arg Arg Ala Arg Phe Leu Arg Tyr Ser Asp Glu Thr Ile 
                85                  90                  95      


Leu Ser Leu Ile Tyr Leu Phe Ile Gly Tyr Phe Arg Tyr Leu Val Asp 
            100                 105                 110         


Arg Lys Arg Phe Gly Ser Leu Arg His Asp Ile Asp Ile Glu Ala Pro 
        115                 120                 125             


Gln Glu Glu Cys Tyr Asn Asn Lys Glu Lys Gly Met Thr Glu Asn Ile 
    130                 135                 140                 


Lys Tyr Gly Lys Arg Cys Leu Val Gly Thr Ala Ala Leu Tyr Leu Ile 
145                 150                 155                 160 


Leu Ala Ile Gly Ile Ile Ile Ile Ile Arg Thr Thr Asp Ala Gln Val 
                165                 170                 175     


Val Trp Arg Leu Pro Pro Leu Val Val Pro Val Glu Glu Ser Glu Ile 
            180                 185                 190         


Ile Phe Trp Asp Cys Trp Ala Pro Glu Glu Pro Ala Cys Gln Asp Phe 
        195                 200                 205             


Leu Gly Ala Met Ile His Leu Lys Ala Ser Thr Asn Ile Ser Asn Thr 
    210                 215                 220                 


Glu Gly Pro Thr Leu Gly Asn Trp Ala Arg Glu Ile Trp Ala Thr Leu 
225                 230                 235                 240 


Phe Lys Lys Ala Thr Arg Gln Cys Arg Arg Gly Arg Ile Trp Lys Arg 
                245                 250                 255     


Trp Asn Glu Thr Ile Thr Gly Pro Ile Gly Cys Ala Asn Asn Thr Cys 
            260                 265                 270         


Tyr Asn Ile Ser Val Ile Val Pro Asp Tyr Gln Cys Tyr Ile Asp Arg 
        275                 280                 285             


Val Asp Thr Trp Leu Gln Gly Lys Val Asn Ile Ser Leu Cys Leu Thr 
    290                 295                 300                 


Gly Gly Lys Met Leu Tyr Asn Lys Glu Thr Lys Gln Leu Ser Tyr Cys 
305                 310                 315                 320 


Thr Asp Pro Leu Gln Ile Pro Leu Ile Asn Tyr Thr Phe Gly Pro Asn 
                325                 330                 335     


Gln Thr Cys Met Trp Asn Ile Ser Gln Ile Gln Asp Pro Glu Ile Pro 
            340                 345                 350         


Lys Cys Gly Trp Trp Asn Gln Gln Ala Tyr Tyr Asn Asn Cys Lys Trp 
        355                 360                 365             


Glu Arg Thr Asp Val Lys Phe Gln Cys Gln Arg Thr Gln Ser Gln Pro 
    370                 375                 380                 


Gly Ser Trp Ile Arg Ala Ile Ser Ser Trp Lys Gln Gly Asn Arg Trp 
385                 390                 395                 400 


Glu Trp Arg Pro Asp Phe Glu Ser Glu Arg Val Lys Val Ser Leu Gln 
                405                 410                 415     


Cys Asn Ser Thr Arg Asn Leu Thr Phe Ala Met Arg Ser Ser Gly Asp 
            420                 425                 430         


Tyr Gly Glu Ile Thr Gly Ala Trp Ile Glu Phe Gly Cys His Arg Asn 
        435                 440                 445             


Lys Ser Ile Arg His Asn Ala Ala Arg Phe Arg Ile Arg Cys Arg Trp 
    450                 455                 460                 


Asn Glu Gly Asp Asn Asn Ser Leu Ile Asp Thr Cys Gly Glu Thr Gln 
465                 470                 475                 480 


Asn Val Ser Gly Ala Asn Pro Val Asp Cys Thr Met Tyr Ala Asn Lys 
                485                 490                 495     


Met Tyr Asn Cys Ser Leu Gln Asp Gly Phe Thr Met Lys Val Asp Asp 
            500                 505                 510         


Leu Ile Met His Phe Asn Met Thr Lys Ala Val Glu Met Tyr Asn Ile 
        515                 520                 525             


Ala Gly Asn Trp Ser Cys Met Ser Asp Leu Pro Thr Glu Trp Gly Tyr 
    530                 535                 540                 


Met Asn Cys Asn Cys Thr Asn Asp Thr Ser Asn Asn Asn Thr Arg Lys 
545                 550                 555                 560 


Met Lys Cys Pro Lys Glu Asn Gly Ile Leu Arg Asn Trp Tyr Asn Pro 
                565                 570                 575     


Val Ala Gly Leu Arg Gln Ser Leu Glu Lys Tyr Gln Val Val Lys Gln 
            580                 585                 590         


Pro Asp Tyr Leu Leu Val Pro Glu Glu Val Met Glu Tyr Lys Pro Arg 
        595                 600                 605             


Arg Lys Arg Ala Ala Ile His Val Met Leu Ala Leu Ala Thr Val Leu 
    610                 615                 620                 


Ser Met Ala Gly Ala Gly Thr Gly Ala Thr Ala Ile Gly Met Val Thr 
625                 630                 635                 640 


Gln Tyr His Gln Val Leu Ala Thr Gln Gln Glu Ala Ile Glu Lys Val 
                645                 650                 655     


Thr Glu Ala Leu Lys Ile Thr Asn Leu Arg Leu Val Thr Leu Glu His 
            660                 665                 670         


Gln Val Leu Val Ile Gly Leu Lys Val Glu Ala Met Glu Lys Phe Arg 
        675                 680                 685             


Tyr Thr Ala Phe Ala Met Gln Glu Leu Gly Cys Asn Gln Asn Gln Phe 
    690                 695                 700                 


Phe Cys Lys Val Pro Pro Glu Leu Trp Arg Arg Tyr Asn Met Thr Ile 
705                 710                 715                 720 


Asn Gln Thr Ile Trp Asn His Gly Asn Ile Thr Leu Gly Glu Trp Tyr 
                725                 730                 735     


Asn Gln Thr Lys Asp Leu Gln Lys Lys Phe Tyr Gly Ile Ile Met Asp 
            740                 745                 750         


Ile Glu Gln Asn Asn Val Gln Gly Lys Lys Gly Leu Gln Gln Leu Gln 
        755                 760                 765             


Lys Trp Glu Asp Trp Val Gly Trp Ile Gly Asn Ile Pro Gln Tyr Leu 
    770                 775                 780                 


Lys Gly Leu Leu Gly Ser Ile Val Gly Ile Gly Leu Gly Ile Leu Leu 
785                 790                 795                 800 


Leu Ile Leu Cys Leu Pro Thr Leu Val Asp Cys Ile Arg Asn Cys Ile 
                805                 810                 815     


His Lys Ile Leu Gly Tyr Thr Val Ile Ala Met Pro Glu Val Asp Gly 
            820                 825                 830         


Glu Glu Ile Gln Pro Gln Met Glu Leu Arg Arg Asn Gly Arg Gln Cys 
        835                 840                 845             


Gly Met Ser Glu Lys Glu Glu Glu 
    850                 855     


<210>  378
<211>  856
<212>  PRT
<213>  Artificial sequence

<220>
<223>  Mutated sequence

<400>  378

Met Ala Glu Gly Phe Val Ala Asn Gly Gln Trp Ile Gly Pro Glu Glu 
1               5                   10                  15      


Ala Glu Glu Leu Leu Asp Phe Asp Ile Ala Thr Gln Leu Asn Glu Glu 
            20                  25                  30          


Gly Pro Leu Asn Pro Gly Ile Asn Pro Phe Arg Val Pro Gly Ile Thr 
        35                  40                  45              


Gln Lys Glu Lys Gln Glu Tyr Cys Asn Thr Leu Gln Pro Lys Leu Gln 
    50                  55                  60                  


Ala Leu Arg Asn Glu Ile Gln Glu Val Lys Leu Glu Glu Arg Asn Ala 
65                  70                  75                  80  


Gly Lys Phe Arg Arg Ala Arg Phe Leu Arg Tyr Ser Asp Glu Thr Ile 
                85                  90                  95      


Leu Ser Leu Ile Tyr Ser Phe Val Gly Tyr Phe Arg Tyr Leu Val Asp 
            100                 105                 110         


Arg Lys Lys Phe Gly Ser Leu Arg His Asp Ile Asp Ile Glu Ala Pro 
        115                 120                 125             


Gln Glu Glu Tyr Tyr Asn Asn Lys Glu Lys Gly Met Thr Asp Asn Val 
    130                 135                 140                 


Lys Tyr Gly Lys Arg Cys Leu Val Gly Thr Ala Ala Phe Tyr Leu Leu 
145                 150                 155                 160 


Leu Ala Ile Gly Ile Ile Ile Ile Ile Arg Thr Val Asp Ala Gln Val 
                165                 170                 175     


Val Trp Arg Leu Pro Pro Leu Val Val Pro Val Glu Glu Ser Glu Ile 
            180                 185                 190         


Ile Phe Trp Asp Cys Trp Ala Pro Glu Glu Pro Ala Cys Gln Asp Phe 
        195                 200                 205             


Leu Gly Ala Met Ile His Leu Lys Ala Ser Thr Asn Ile Arg Ile Gln 
    210                 215                 220                 


Glu Gly Pro Thr Leu Gly Asn Trp Ala Arg Glu Ile Trp Ala Thr Leu 
225                 230                 235                 240 


Phe Lys Lys Ala Thr Arg Gln Cys Arg Arg Gly Arg Ile Trp Lys Arg 
                245                 250                 255     


Trp Asn Glu Thr Ile Thr Gly Pro Ile Gly Cys Ala Asn Asn Thr Cys 
            260                 265                 270         


Tyr Asn Ile Ser Val Ile Ile Pro Asp Tyr Gln Cys Tyr Ile Asp Arg 
        275                 280                 285             


Val Asp Thr Trp Leu Gln Gly Lys Val Asn Ile Ser Ile Cys Leu Thr 
    290                 295                 300                 


Gly Gly Lys Met Leu Tyr Asn Lys Glu Thr Lys Gln Leu Ser Tyr Cys 
305                 310                 315                 320 


Thr Asp Pro Leu Gln Ile Pro Leu Ile Asn Tyr Thr Phe Gly Pro Gln 
                325                 330                 335     


Gln Thr Cys Met Trp Asn Thr Ser Gln Ile Gln Asp Pro Glu Ile Pro 
            340                 345                 350         


Lys Cys Gly Trp Trp Asn Gln Lys Ala Tyr Tyr Asn Gln Cys Ser Trp 
        355                 360                 365             


Glu Gln Thr Asp Val Lys Phe Gln Cys Gln Arg Thr Gln Ser Gln Pro 
    370                 375                 380                 


Gly Ser Trp Ile Arg Ala Ile Ser Ser Trp Arg Gln Arg Asn Arg Trp 
385                 390                 395                 400 


Glu Trp Arg Pro Asp Phe Glu Ser Glu Arg Val Lys Val Ser Leu Gln 
                405                 410                 415     


Cys Asn Ser Thr Gln Asn Leu Thr Phe Ala Met Arg Ser Ser Gly Asp 
            420                 425                 430         


Tyr Gly Glu Ile Thr Gly Ala Trp Ile Glu Phe Gly Cys His Arg Asn 
        435                 440                 445             


Lys Ser Lys His His Asn Glu Ala Arg Phe Arg Ile Arg Cys Arg Trp 
    450                 455                 460                 


Asn Glu Gly Asn Asn Asn Ser Leu Ile Asp Thr Cys Gly Lys Thr Gln 
465                 470                 475                 480 


Asn Val Leu Gly Ala Asn Pro Val Asp Cys Thr Met Tyr Ala Asn Arg 
                485                 490                 495     


Met Tyr Asn Cys Ser Leu Gln Asp Gly Phe Thr Met Lys Val Asp Asp 
            500                 505                 510         


Leu Ile Met His Phe Asn Met Thr Lys Ala Val Glu Met Tyr Asn Ile 
        515                 520                 525             


Ala Gly Asn Trp Ser Cys Met Ser Asp Leu Pro Thr Asn Trp Gly Tyr 
    530                 535                 540                 


Met Lys Cys Asn Cys Thr Asn Asp Thr Ser Asn Asn His Thr Ile Lys 
545                 550                 555                 560 


Met Glu Cys Pro Glu Glu Lys Gly Ile Leu Arg Asn Trp Tyr Asn Pro 
                565                 570                 575     


Val Ala Gly Leu Arg Gln Ser Leu Glu Lys Tyr Gln Val Val Lys Gln 
            580                 585                 590         


Pro Asp Tyr Leu Val Val Pro Gly Glu Val Met Glu Tyr Lys Pro Arg 
        595                 600                 605             


Arg Lys Arg Ala Ala Ile His Val Met Leu Ala Leu Ala Thr Val Leu 
    610                 615                 620                 


Ser Met Ala Gly Ala Gly Thr Gly Ala Thr Ala Ile Gly Met Val Thr 
625                 630                 635                 640 


Gln Tyr His Gln Val Leu Ala Thr His Gln Glu Ala Ile Glu Lys Val 
                645                 650                 655     


Thr Glu Ala Leu Lys Ile Asn Asn Leu Arg Leu Val Thr Leu Glu His 
            660                 665                 670         


Gln Val Leu Val Ile Gly Leu Lys Val Glu Ala Ile Glu Lys Arg Leu 
        675                 680                 685             


Tyr Thr Ala Phe Ala Met Gln Glu Leu Gly Cys Asn Gln Asn Gln Phe 
    690                 695                 700                 


Phe Cys Lys Val Pro Leu Glu Leu Trp Arg Arg Tyr Asn Met Thr Ile 
705                 710                 715                 720 


Asn Gln Thr Ile Trp Asn His Gly Asn Ile Thr Leu Gly Glu Trp Tyr 
                725                 730                 735     


Asn Gln Thr Lys Ala Leu Gln His Lys Phe Tyr Glu Ile Ile Met Asp 
            740                 745                 750         


Ile Glu Gln Asn Asn Val Gln Gly Lys Lys Gly Leu Gln Gln Leu Gln 
        755                 760                 765             


Lys Trp Glu Asp Trp Val Gly Trp Ile Gly Asn Ile Pro Gln Tyr Leu 
    770                 775                 780                 


Lys Gly Leu Leu Gly Gly Ile Leu Gly Ile Gly Leu Gly Ile Leu Leu 
785                 790                 795                 800 


Leu Ile Leu Cys Leu Pro Thr Leu Val Asp Cys Ile Arg Asn Cys Ile 
                805                 810                 815     


His Lys Ile Leu Gly Tyr Thr Val Ile Ala Met Pro Asp Val Asp Glu 
            820                 825                 830         


Glu Glu Ile Gln Pro Gln Met Glu Leu Arg Arg Asn Gly Arg Gln Cys 
        835                 840                 845             


Gly Met Ser Glu Lys Glu Glu Glu 
    850                 855     


<210>  379
<211>  856
<212>  PRT
<213>  Artificial sequence

<220>
<223>  Mutated sequence

<400>  379

Met Ala Glu Gly Phe Val Ala Asn Gly Gln Trp Ile Gly Pro Glu Glu 
1               5                   10                  15      


Ala Glu Glu Leu Leu Asp Phe Asp Ile Ala Thr Gln Leu Asn Glu Glu 
            20                  25                  30          


Gly Pro Leu Asn Pro Gly Ile Asn Pro Phe Arg Val Pro Gly Ile Thr 
        35                  40                  45              


Gln Lys Glu Lys Gln Glu Tyr Cys Asn Thr Leu Gln Pro Lys Leu Gln 
    50                  55                  60                  


Ala Leu Arg Asn Glu Ile Gln Glu Val Lys Leu Glu Glu Arg Asn Ala 
65                  70                  75                  80  


Gly Lys Phe Arg Arg Ala Arg Phe Leu Arg Tyr Ser Asp Glu Thr Ile 
                85                  90                  95      


Leu Ser Leu Ile Tyr Ser Phe Val Gly Tyr Phe Arg Tyr Leu Val Asp 
            100                 105                 110         


Arg Lys Lys Phe Gly Ser Leu Arg His Asp Ile Asp Ile Glu Ala Pro 
        115                 120                 125             


Gln Glu Glu Tyr Tyr Asn Asn Lys Glu Lys Gly Met Thr Asp Asn Val 
    130                 135                 140                 


Lys Tyr Gly Lys Arg Cys Leu Val Gly Thr Ala Ala Phe Tyr Leu Leu 
145                 150                 155                 160 


Leu Ala Ile Gly Ile Ile Ile Ile Ile Arg Thr Val Asp Ala Gln Val 
                165                 170                 175     


Val Trp Arg Leu Pro Pro Leu Val Val Pro Val Glu Glu Ser Glu Ile 
            180                 185                 190         


Ile Phe Trp Asp Cys Trp Ala Pro Glu Glu Pro Ala Cys Gln Asp Phe 
        195                 200                 205             


Leu Gly Ala Met Ile His Leu Lys Ala Ser Thr Asn Ile Arg Ile Gln 
    210                 215                 220                 


Glu Gly Pro Thr Leu Gly Asn Trp Ala Arg Glu Ile Trp Ala Thr Leu 
225                 230                 235                 240 


Phe Lys Lys Ala Thr Arg Gln Cys Arg Arg Gly Arg Ile Trp Lys Arg 
                245                 250                 255     


Trp Asn Glu Thr Ile Thr Gly Pro Ile Gly Cys Ala Asn Asn Thr Cys 
            260                 265                 270         


Tyr Asn Ile Ser Val Ile Ile Pro Asp Tyr Gln Cys Tyr Ile Asp Arg 
        275                 280                 285             


Val Asp Thr Trp Leu Gln Gly Lys Val Asn Ile Ser Ile Cys Leu Thr 
    290                 295                 300                 


Gly Gly Lys Met Leu Tyr Asn Lys Glu Thr Lys Gln Leu Ser Tyr Cys 
305                 310                 315                 320 


Thr Asp Pro Leu Gln Ile Pro Leu Ile Asn Tyr Thr Phe Gly Pro Gln 
                325                 330                 335     


Gln Thr Cys Met Trp Asn Thr Ser Gln Ile Gln Asp Pro Glu Ile Pro 
            340                 345                 350         


Lys Cys Gly Trp Trp Asn Gln Lys Ala Tyr Tyr Asn Gln Cys Ser Trp 
        355                 360                 365             


Glu Gln Thr Asp Val Lys Phe Gln Cys Gln Arg Thr Gln Ser Gln Pro 
    370                 375                 380                 


Gly Ser Trp Ile Arg Ala Ile Ser Ser Trp Arg Gln Arg Asn Arg Trp 
385                 390                 395                 400 


Glu Trp Arg Pro Asp Phe Glu Ser Glu Arg Val Lys Val Ser Leu Gln 
                405                 410                 415     


Cys Asn Ser Thr Gln Asn Leu Thr Phe Ala Met Arg Ser Ser Gly Asp 
            420                 425                 430         


Tyr Gly Glu Ile Thr Gly Ala Trp Ile Glu Phe Gly Cys His Arg Asn 
        435                 440                 445             


Lys Ser Lys His His Asn Glu Ala Arg Phe Arg Ile Arg Cys Arg Trp 
    450                 455                 460                 


Asn Glu Gly Asn Asn Asn Ser Leu Ile Asp Thr Cys Gly Lys Thr Gln 
465                 470                 475                 480 


Asn Val Leu Gly Ala Asn Pro Val Asp Cys Thr Met Tyr Ala Asn Arg 
                485                 490                 495     


Met Tyr Asn Cys Ser Leu Gln Asp Gly Phe Thr Met Lys Val Asp Asp 
            500                 505                 510         


Leu Ile Met His Phe Asn Met Thr Lys Ala Val Glu Met Tyr Asn Ile 
        515                 520                 525             


Ala Gly Asn Trp Ser Cys Met Ser Asp Leu Pro Thr Asn Trp Gly Tyr 
    530                 535                 540                 


Met Lys Cys Asn Cys Thr Asn Asp Thr Ser Asn Asn His Thr Ile Lys 
545                 550                 555                 560 


Met Glu Cys Pro Glu Glu Lys Gly Ile Leu Arg Asn Trp Tyr Asn Pro 
                565                 570                 575     


Val Ala Gly Leu Arg Gln Ser Leu Glu Lys Tyr Gln Val Val Lys Gln 
            580                 585                 590         


Pro Asp Tyr Leu Val Val Pro Gly Glu Val Met Glu Tyr Lys Pro Arg 
        595                 600                 605             


Arg Lys Arg Ala Ala Ile His Val Met Leu Ala Leu Ala Thr Val Leu 
    610                 615                 620                 


Ser Met Ala Gly Ala Gly Thr Gly Ala Thr Ala Ile Gly Met Val Thr 
625                 630                 635                 640 


Gln Tyr His Gln Val Leu Ala Thr His Gln Glu Ala Ile Glu Lys Val 
                645                 650                 655     


Thr Glu Ala Leu Lys Ile Asn Asn Leu Arg Leu Val Thr Leu Glu His 
            660                 665                 670         


Gln Val Leu Val Ile Gly Leu Lys Val Glu Ala Ile Glu Lys Phe Arg 
        675                 680                 685             


Tyr Thr Ala Phe Ala Met Gln Glu Leu Gly Cys Asn Gln Asn Gln Phe 
    690                 695                 700                 


Phe Cys Lys Val Pro Leu Glu Leu Trp Arg Arg Tyr Asn Met Thr Ile 
705                 710                 715                 720 


Asn Gln Thr Ile Trp Asn His Gly Asn Ile Thr Leu Gly Glu Trp Tyr 
                725                 730                 735     


Asn Gln Thr Lys Ala Leu Gln His Lys Phe Tyr Glu Ile Ile Met Asp 
            740                 745                 750         


Ile Glu Gln Asn Asn Val Gln Gly Lys Lys Gly Leu Gln Gln Leu Gln 
        755                 760                 765             


Lys Trp Glu Asp Trp Val Gly Trp Ile Gly Asn Ile Pro Gln Tyr Leu 
    770                 775                 780                 


Lys Gly Leu Leu Gly Gly Ile Leu Gly Ile Gly Leu Gly Ile Leu Leu 
785                 790                 795                 800 


Leu Ile Leu Cys Leu Pro Thr Leu Val Asp Cys Ile Arg Asn Cys Ile 
                805                 810                 815     


His Lys Ile Leu Gly Tyr Thr Val Ile Ala Met Pro Asp Val Asp Glu 
            820                 825                 830         


Glu Glu Ile Gln Pro Gln Met Glu Leu Arg Arg Asn Gly Arg Gln Cys 
        835                 840                 845             


Gly Met Ser Glu Lys Glu Glu Glu 
    850                 855     


<210>  380
<211>  854
<212>  PRT
<213>  Artificial sequence

<220>
<223>  Mutated sequence

<400>  380

Met Ala Glu Gly Phe Ala Ala Asn Arg Gln Trp Ile Gly Pro Glu Glu 
1               5                   10                  15      


Ala Glu Glu Leu Leu Asp Phe Asp Ile Ala Ile Gln Met Asn Glu Glu 
            20                  25                  30          


Gly Pro Leu Asn Pro Gly Val Asn Pro Phe Arg Val Pro Gly Ile Thr 
        35                  40                  45              


Glu Ala Glu Lys Gln Glu Tyr Cys Asn Ile Leu Gln Pro Lys Leu Gln 
    50                  55                  60                  


Asp Leu Lys Gly Lys Ile Gln Glu Val Lys Leu Glu Glu Gly Asn Ala 
65                  70                  75                  80  


Gly Lys Phe Arg Arg Ala Arg Phe Leu Arg Tyr Ser Asp Glu Thr Val 
                85                  90                  95      


Leu Ser Leu Ile His Leu Phe Ile Gly Tyr Cys Pro His Leu Cys Arg 
            100                 105                 110         


Arg His Glu Leu Gly Ser Leu Arg His Asp Ile Asp Ile Glu Ala Leu 
        115                 120                 125             


Gln Glu Glu Arg Tyr Asn Asp Arg Glu Lys Gly Ile Thr Asp Asn Ile 
    130                 135                 140                 


Lys Tyr Gly Lys Arg Cys Leu Ile Gly Thr Ala Val Leu Tyr Leu Leu 
145                 150                 155                 160 


Leu Ser Leu Gly Ile Ile Ile His Thr Cys Lys Ala Gln Val Val Trp 
                165                 170                 175     


Arg Leu Pro Pro Leu Val Val Pro Val Glu Glu Ser Glu Ile Ile Phe 
            180                 185                 190         


Trp Asp Cys Trp Ala Pro Glu Glu Pro Ala Cys Gln Asp Phe Leu Gly 
        195                 200                 205             


Ala Met Ile His Leu Lys Ala Ser Thr Asn Ile Ser Ile Gln Glu Gly 
    210                 215                 220                 


Pro Thr Leu Gly Asn Trp Ala Arg Glu Ile Trp Gly Thr Leu Phe Lys 
225                 230                 235                 240 


Lys Ala Thr Arg Gln Cys Arg Arg Gly Arg Ile Trp Arg Arg Trp Asn 
                245                 250                 255     


Glu Thr Ile Thr Gly Pro Leu Gly Cys Ala Asn Asn Thr Cys Tyr Asn 
            260                 265                 270         


Ile Ser Val Ile Val Pro Asp Tyr Gln Cys Tyr Leu Asp Arg Val Asp 
        275                 280                 285             


Thr Trp Leu Gln Gly Lys Val Asn Ile Ser Leu Cys Leu Thr Gly Gly 
    290                 295                 300                 


Lys Met Leu Tyr Asn Lys Glu Thr Lys Gln Leu Ser Tyr Cys Thr Asp 
305                 310                 315                 320 


Pro Leu Gln Ile Pro Leu Ile Asn Tyr Thr Phe Gly Pro Asn Gln Thr 
                325                 330                 335     


Cys Met Trp Asn Thr Ser Gln Ile Gln Asp Pro Glu Ile Pro Lys Cys 
            340                 345                 350         


Gly Trp Trp Asn Gln Asn Ala Tyr Tyr Asn Ser Cys Arg Trp Glu His 
        355                 360                 365             


Thr Asp Val Gln Phe Gln Cys Gln Arg Thr Gln Ser Gln Pro Gly Ser 
    370                 375                 380                 


Trp Ile Arg Ala Ile Ser Ser Trp Lys Gln Arg Asn Arg Trp Glu Trp 
385                 390                 395                 400 


Arg Pro Asp Phe Glu Ser Glu Lys Val Lys Val Ser Leu Gln Cys Asn 
                405                 410                 415     


Ser Thr Lys Asn Leu Thr Phe Ala Met Arg Ser Ser Gly Asp Tyr Gly 
            420                 425                 430         


Glu Val Thr Gly Ala Trp Ile Glu Phe Gly Cys His Arg Thr Lys Ser 
        435                 440                 445             


Lys Tyr His Thr Glu Ala Arg Phe Arg Ile Arg Cys Arg Trp Asn Val 
    450                 455                 460                 


Gly Asp Asn Thr Ser Leu Ile Asp Thr Cys Gly Glu Thr Gln Asn Val 
465                 470                 475                 480 


Ser Arg Ala Asn Pro Val Asp Cys Thr Met Tyr Ala Asn Arg Met Tyr 
                485                 490                 495     


Asn Cys Ser Leu Gln Asn Gly Phe Thr Met Lys Val Asp Asp Leu Ile 
            500                 505                 510         


Met His Phe Asn Lys Thr Lys Ala Val Glu Met Tyr Asn Ile Ala Gly 
        515                 520                 525             


Asn Trp Ser Cys Lys Ser Asp Leu Pro Pro Thr Trp Gly Tyr Met Asn 
    530                 535                 540                 


Cys Asn Cys Thr Asn Ser Thr Asn Ser Gly Thr Gly Ile Arg Met Ala 
545                 550                 555                 560 


Cys Pro Arg Asn Gln Gly Ile Leu Arg Asn Trp Tyr Asn Pro Val Ala 
                565                 570                 575     


Gly Leu Arg Gln Ser Leu Glu Lys Tyr Gln Val Val Lys Gln Pro Asp 
            580                 585                 590         


Tyr Leu Val Val Pro Gly Glu Val Met Glu Tyr Lys Pro Arg Arg Lys 
        595                 600                 605             


Arg Ala Ala Ile His Val Met Leu Ala Leu Ala Thr Val Leu Ser Met 
    610                 615                 620                 


Ala Gly Ala Gly Thr Gly Ala Thr Ala Ile Gly Met Val Thr Gln Tyr 
625                 630                 635                 640 


Gln Gln Val Leu Ala Thr His Gln Glu Ala Ile Glu Lys Val Thr Glu 
                645                 650                 655     


Ala Leu Lys Ile Asn Asn Leu Arg Leu Val Thr Leu Glu His Gln Val 
            660                 665                 670         


Leu Val Ile Gly Leu Lys Val Glu Ala Met Glu Lys Arg Leu Tyr Thr 
        675                 680                 685             


Ala Phe Ala Met Gln Glu Leu Gly Cys Asn Gln Asn Gln Phe Phe Cys 
    690                 695                 700                 


Lys Val Pro Ser Ala Leu Trp Glu Arg Tyr Asn Met Thr Ile Asn Gln 
705                 710                 715                 720 


Thr Ile Trp Asn His Gly Asn Ile Thr Leu Gly Glu Trp Tyr Asn Gln 
                725                 730                 735     


Thr Lys Asp Leu Gln Gln Arg Phe Tyr Glu Ile Ile Met Asp Ile Glu 
            740                 745                 750         


Gln Asn Asn Val Gln Gly Lys Lys Gly Leu Gln Gln Leu Gln Glu Trp 
        755                 760                 765             


Glu Asp Trp Val Gly Trp Ile Gly Asn Ile Pro Gln Tyr Leu Lys Gly 
    770                 775                 780                 


Leu Leu Gly Gly Ile Leu Gly Ile Gly Leu Gly Met Leu Leu Leu Ile 
785                 790                 795                 800 


Leu Cys Leu Pro Thr Leu Val Asp Cys Ile Arg Asn Cys Ile His Lys 
                805                 810                 815     


Ile Leu Gly Tyr Thr Val Ile Ala Met Pro Glu Val Glu Glu Glu Glu 
            820                 825                 830         


Ile Gln Pro Gln Met Glu Leu Arg Arg Asn Gly Arg Gln Cys Gly Met 
        835                 840                 845             


Ser Glu Lys Glu Glu Glu 
    850                 


<210>  381
<211>  854
<212>  PRT
<213>  Artificial sequence

<220>
<223>  Mutated sequence

<400>  381

Met Ala Glu Gly Phe Ala Ala Asn Arg Gln Trp Ile Gly Pro Glu Glu 
1               5                   10                  15      


Ala Glu Glu Leu Leu Asp Phe Asp Ile Ala Ile Gln Met Asn Glu Glu 
            20                  25                  30          


Gly Pro Leu Asn Pro Gly Val Asn Pro Phe Arg Val Pro Gly Ile Thr 
        35                  40                  45              


Glu Ala Glu Lys Gln Glu Tyr Cys Asn Ile Leu Gln Pro Lys Leu Gln 
    50                  55                  60                  


Asp Leu Lys Gly Lys Ile Gln Glu Val Lys Leu Glu Glu Gly Asn Ala 
65                  70                  75                  80  


Gly Lys Phe Arg Arg Ala Arg Phe Leu Arg Tyr Ser Asp Glu Thr Val 
                85                  90                  95      


Leu Ser Leu Ile His Leu Phe Ile Gly Tyr Cys Pro His Leu Cys Arg 
            100                 105                 110         


Arg His Glu Leu Gly Ser Leu Arg His Asp Ile Asp Ile Glu Ala Leu 
        115                 120                 125             


Gln Glu Glu Arg Tyr Asn Asp Arg Glu Lys Gly Ile Thr Asp Asn Ile 
    130                 135                 140                 


Lys Tyr Gly Lys Arg Cys Leu Ile Gly Thr Ala Val Leu Tyr Leu Leu 
145                 150                 155                 160 


Leu Ser Leu Gly Ile Ile Ile His Thr Cys Lys Ala Gln Val Val Trp 
                165                 170                 175     


Arg Leu Pro Pro Leu Val Val Pro Val Glu Glu Ser Glu Ile Ile Phe 
            180                 185                 190         


Trp Asp Cys Trp Ala Pro Glu Glu Pro Ala Cys Gln Asp Phe Leu Gly 
        195                 200                 205             


Ala Met Ile His Leu Lys Ala Ser Thr Asn Ile Ser Ile Gln Glu Gly 
    210                 215                 220                 


Pro Thr Leu Gly Asn Trp Ala Arg Glu Ile Trp Gly Thr Leu Phe Lys 
225                 230                 235                 240 


Lys Ala Thr Arg Gln Cys Arg Arg Gly Arg Ile Trp Arg Arg Trp Asn 
                245                 250                 255     


Glu Thr Ile Thr Gly Pro Leu Gly Cys Ala Asn Asn Thr Cys Tyr Asn 
            260                 265                 270         


Ile Ser Val Ile Val Pro Asp Tyr Gln Cys Tyr Leu Asp Arg Val Asp 
        275                 280                 285             


Thr Trp Leu Gln Gly Lys Val Asn Ile Ser Leu Cys Leu Thr Gly Gly 
    290                 295                 300                 


Lys Met Leu Tyr Asn Lys Glu Thr Lys Gln Leu Ser Tyr Cys Thr Asp 
305                 310                 315                 320 


Pro Leu Gln Ile Pro Leu Ile Asn Tyr Thr Phe Gly Pro Asn Gln Thr 
                325                 330                 335     


Cys Met Trp Asn Thr Ser Gln Ile Gln Asp Pro Glu Ile Pro Lys Cys 
            340                 345                 350         


Gly Trp Trp Asn Gln Asn Ala Tyr Tyr Asn Ser Cys Arg Trp Glu His 
        355                 360                 365             


Thr Asp Val Gln Phe Gln Cys Gln Arg Thr Gln Ser Gln Pro Gly Ser 
    370                 375                 380                 


Trp Ile Arg Ala Ile Ser Ser Trp Lys Gln Arg Asn Arg Trp Glu Trp 
385                 390                 395                 400 


Arg Pro Asp Phe Glu Ser Glu Lys Val Lys Val Ser Leu Gln Cys Asn 
                405                 410                 415     


Ser Thr Lys Asn Leu Thr Phe Ala Met Arg Ser Ser Gly Asp Tyr Gly 
            420                 425                 430         


Glu Val Thr Gly Ala Trp Ile Glu Phe Gly Cys His Arg Thr Lys Ser 
        435                 440                 445             


Lys Tyr His Thr Glu Ala Arg Phe Arg Ile Arg Cys Arg Trp Asn Val 
    450                 455                 460                 


Gly Asp Asn Thr Ser Leu Ile Asp Thr Cys Gly Glu Thr Gln Asn Val 
465                 470                 475                 480 


Ser Arg Ala Asn Pro Val Asp Cys Thr Met Tyr Ala Asn Arg Met Tyr 
                485                 490                 495     


Asn Cys Ser Leu Gln Asn Gly Phe Thr Met Lys Val Asp Asp Leu Ile 
            500                 505                 510         


Met His Phe Asn Lys Thr Lys Ala Val Glu Met Tyr Asn Ile Ala Gly 
        515                 520                 525             


Asn Trp Ser Cys Lys Ser Asp Leu Pro Pro Thr Trp Gly Tyr Met Asn 
    530                 535                 540                 


Cys Asn Cys Thr Asn Ser Thr Asn Ser Gly Thr Gly Ile Arg Met Ala 
545                 550                 555                 560 


Cys Pro Arg Asn Gln Gly Ile Leu Arg Asn Trp Tyr Asn Pro Val Ala 
                565                 570                 575     


Gly Leu Arg Gln Ser Leu Glu Lys Tyr Gln Val Val Lys Gln Pro Asp 
            580                 585                 590         


Tyr Leu Val Val Pro Gly Glu Val Met Glu Tyr Lys Pro Arg Arg Lys 
        595                 600                 605             


Arg Ala Ala Ile His Val Met Leu Ala Leu Ala Thr Val Leu Ser Met 
    610                 615                 620                 


Ala Gly Ala Gly Thr Gly Ala Thr Ala Ile Gly Met Val Thr Gln Tyr 
625                 630                 635                 640 


Gln Gln Val Leu Ala Thr His Gln Glu Ala Ile Glu Lys Val Thr Glu 
                645                 650                 655     


Ala Leu Lys Ile Asn Asn Leu Arg Leu Val Thr Leu Glu His Gln Val 
            660                 665                 670         


Leu Val Ile Gly Leu Lys Val Glu Ala Met Glu Lys Phe Arg Tyr Thr 
        675                 680                 685             


Ala Phe Ala Met Gln Glu Leu Gly Cys Asn Gln Asn Gln Phe Phe Cys 
    690                 695                 700                 


Lys Val Pro Ser Ala Leu Trp Glu Arg Tyr Asn Met Thr Ile Asn Gln 
705                 710                 715                 720 


Thr Ile Trp Asn His Gly Asn Ile Thr Leu Gly Glu Trp Tyr Asn Gln 
                725                 730                 735     


Thr Lys Asp Leu Gln Gln Arg Phe Tyr Glu Ile Ile Met Asp Ile Glu 
            740                 745                 750         


Gln Asn Asn Val Gln Gly Lys Lys Gly Leu Gln Gln Leu Gln Glu Trp 
        755                 760                 765             


Glu Asp Trp Val Gly Trp Ile Gly Asn Ile Pro Gln Tyr Leu Lys Gly 
    770                 775                 780                 


Leu Leu Gly Gly Ile Leu Gly Ile Gly Leu Gly Met Leu Leu Leu Ile 
785                 790                 795                 800 


Leu Cys Leu Pro Thr Leu Val Asp Cys Ile Arg Asn Cys Ile His Lys 
                805                 810                 815     


Ile Leu Gly Tyr Thr Val Ile Ala Met Pro Glu Val Glu Glu Glu Glu 
            820                 825                 830         


Ile Gln Pro Gln Met Glu Leu Arg Arg Asn Gly Arg Gln Cys Gly Met 
        835                 840                 845             


Ser Glu Lys Glu Glu Glu 
    850                 


<210>  382
<211>  856
<212>  PRT
<213>  Artificial sequence

<220>
<223>  Mutated sequence

<400>  382

Met Ala Glu Gly Phe Ala Ala Asn Arg Gln Trp Ile Gly Pro Glu Glu 
1               5                   10                  15      


Ala Glu Glu Leu Leu Asp Phe Asp Ile Ala Thr Gln Met Ser Glu Glu 
            20                  25                  30          


Gly Pro Leu Asn Pro Gly Val Asn Pro Phe Arg Val Pro Gly Ile Thr 
        35                  40                  45              


Glu Lys Glu Lys Gln Asn Tyr Cys Asn Ile Leu Gln Pro Lys Leu Gln 
    50                  55                  60                  


Asp Leu Arg Asp Glu Ile Gln Glu Val Lys Leu Glu Glu Gly Asn Ala 
65                  70                  75                  80  


Gly Lys Phe Arg Arg Thr Arg Phe Leu Arg Tyr Ser Asp Glu His Val 
                85                  90                  95      


Leu Ser Leu Val His Ala Phe Ile Gly Tyr Cys Ile Tyr Leu Gly Asn 
            100                 105                 110         


Arg Asn Lys Leu Gly Ser Leu Arg His Asp Ile Asp Ile Glu Ala Pro 
        115                 120                 125             


Gln Glu Glu Tyr Tyr Asn Asn Arg Glu Lys Gly Thr Thr Asp Asn Ile 
    130                 135                 140                 


Lys Tyr Gly Arg Arg Cys Cys Leu Gly Thr Val Thr Leu Tyr Leu Ile 
145                 150                 155                 160 


Leu Phe Ile Gly Val Ile Val Tyr Ser Gln Thr Ala Gly Ala Gln Val 
                165                 170                 175     


Val Trp Arg Leu Pro Pro Leu Val Val Pro Val Glu Glu Ser Glu Ile 
            180                 185                 190         


Ile Phe Trp Asp Cys Trp Ala Pro Asp Glu Pro Ala Cys Gln Asp Phe 
        195                 200                 205             


Leu Gly Ala Met Ile His Leu Lys Ala Lys Thr Asn Ile Ser Ile Arg 
    210                 215                 220                 


Glu Gly Pro Thr Leu Gly Asn Trp Ala Arg Glu Ile Trp Ala Thr Leu 
225                 230                 235                 240 


Phe Lys Lys Ala Thr Arg Gln Cys Arg Arg Gly Arg Ile Trp Lys Arg 
                245                 250                 255     


Trp Asn Glu Thr Ile Thr Gly Pro Ser Gly Cys Ala Asn Asn Thr Cys 
            260                 265                 270         


Tyr Asn Val Ser Val Ile Val Pro Asp Tyr Gln Cys Tyr Leu Asp Arg 
        275                 280                 285             


Val Asp Thr Trp Leu Gln Gly Lys Ile Asn Ile Ser Leu Cys Leu Thr 
    290                 295                 300                 


Gly Gly Lys Met Leu Tyr Asn Lys Val Thr Lys Gln Leu Ser Tyr Cys 
305                 310                 315                 320 


Thr Asp Pro Leu Gln Ile Pro Leu Ile Asn Tyr Thr Phe Gly Pro Asn 
                325                 330                 335     


Gln Thr Cys Met Trp Asn Thr Ser Gln Ile Gln Asp Pro Glu Ile Pro 
            340                 345                 350         


Lys Cys Gly Trp Trp Asn Gln Met Ala Tyr Tyr Asn Arg Cys Lys Trp 
        355                 360                 365             


Glu Glu Ala Lys Val Lys Phe His Cys Gln Arg Thr Gln Ser Gln Pro 
    370                 375                 380                 


Gly Ser Trp Arg Arg Ala Ile Ser Ser Trp Lys Gln Arg Asn Arg Trp 
385                 390                 395                 400 


Glu Trp Arg Pro Asp Leu Glu Ser Glu Lys Val Lys Ile Ser Leu Gln 
                405                 410                 415     


Cys Asn Ser Lys Lys Asn Leu Thr Phe Ala Met Arg Ser Ser Gly Asp 
            420                 425                 430         


Tyr Gly Glu Val Thr Gly Ala Trp Ile Glu Phe Gly Cys His Arg Asn 
        435                 440                 445             


Lys Ser Lys His His Ser Glu Ala Arg Phe Arg Ile Arg Cys Arg Trp 
    450                 455                 460                 


Asn Val Gly Ser Asn Thr Ser Leu Ile Asp Thr Cys Gly Asn Thr Gln 
465                 470                 475                 480 


Asp Val Ser Gly Ala Asn Pro Val Asp Cys Thr Met Tyr Ser Asn Lys 
                485                 490                 495     


Met Tyr Asn Cys Ser Leu Gln Asn Gly Phe Thr Met Lys Val Asp Asp 
            500                 505                 510         


Leu Ile Val His Phe Ser Met Thr Lys Ala Val Lys Met Tyr Asn Ile 
        515                 520                 525             


Ala Gly Asn Trp Ser Cys Thr Ser Asp Leu Pro Ser Ser Trp Gly Tyr 
    530                 535                 540                 


Met Asn Cys Asn Cys Thr Asn Ser Ser Ser Ser Tyr Ser Gly Thr Lys 
545                 550                 555                 560 


Met Ala Cys Pro Ser Asn Arg Gly Ile Leu Arg Asn Trp Tyr Asn Pro 
                565                 570                 575     


Val Ala Gly Leu Arg Gln Ser Leu Glu Gln Tyr Gln Val Val Lys Gln 
            580                 585                 590         


Pro Asp Tyr Leu Val Val Pro Glu Glu Val Met Glu Tyr Lys Pro Arg 
        595                 600                 605             


Arg Lys Arg Ala Ala Ile His Val Met Leu Ala Leu Ala Thr Val Leu 
    610                 615                 620                 


Ser Ile Ala Gly Ala Gly Thr Gly Ala Thr Ala Ile Gly Met Val Thr 
625                 630                 635                 640 


Gln Tyr His Gln Val Leu Ala Thr His Gln Glu Ala Ile Glu Lys Val 
                645                 650                 655     


Thr Glu Ala Leu Lys Ile Asn Asn Leu Arg Leu Val Thr Leu Glu His 
            660                 665                 670         


Gln Val Leu Val Ile Gly Leu Lys Val Glu Ala Met Glu Lys Arg Leu 
        675                 680                 685             


Tyr Thr Ala Phe Ala Met Gln Glu Leu Gly Cys Asn Gln Asn Gln Phe 
    690                 695                 700                 


Phe Cys Lys Ile Pro Pro Gly Leu Trp Thr Arg Tyr Asn Met Thr Ile 
705                 710                 715                 720 


Asn Gln Thr Ile Trp Asn His Gly Asn Ile Thr Leu Gly Glu Trp Tyr 
                725                 730                 735     


Asn Lys Thr Lys Asp Leu Gln Gln Lys Phe Tyr Glu Ile Ile Met Asp 
            740                 745                 750         


Ile Glu Gln Asn Asn Val Gln Gly Lys Thr Gly Ile Gln Gln Leu Gln 
        755                 760                 765             


Lys Trp Glu Asp Trp Val Gly Trp Ile Gly Asn Ile Pro Gln Tyr Leu 
    770                 775                 780                 


Lys Gly Leu Leu Gly Gly Ile Leu Gly Ile Gly Leu Gly Val Leu Leu 
785                 790                 795                 800 


Leu Ile Leu Cys Leu Pro Thr Leu Val Asp Cys Ile Arg Asn Cys Ile 
                805                 810                 815     


His Lys Ile Leu Gly Tyr Thr Val Ile Ala Met Pro Glu Val Glu Gly 
            820                 825                 830         


Glu Glu Ile Gln Pro Gln Met Glu Leu Arg Arg Asn Gly Arg Gln Cys 
        835                 840                 845             


Gly Met Ser Glu Lys Glu Glu Glu 
    850                 855     


<210>  383
<211>  856
<212>  PRT
<213>  Artificial sequence

<220>
<223>  Mutated sequence

<400>  383

Met Ala Glu Gly Phe Ala Ala Asn Arg Gln Trp Ile Gly Pro Glu Glu 
1               5                   10                  15      


Ala Glu Glu Leu Leu Asp Phe Asp Ile Ala Thr Gln Met Ser Glu Glu 
            20                  25                  30          


Gly Pro Leu Asn Pro Gly Val Asn Pro Phe Arg Val Pro Gly Ile Thr 
        35                  40                  45              


Glu Lys Glu Lys Gln Asn Tyr Cys Asn Ile Leu Gln Pro Lys Leu Gln 
    50                  55                  60                  


Asp Leu Arg Asp Glu Ile Gln Glu Val Lys Leu Glu Glu Gly Asn Ala 
65                  70                  75                  80  


Gly Lys Phe Arg Arg Thr Arg Phe Leu Arg Tyr Ser Asp Glu His Val 
                85                  90                  95      


Leu Ser Leu Val His Ala Phe Ile Gly Tyr Cys Ile Tyr Leu Gly Asn 
            100                 105                 110         


Arg Asn Lys Leu Gly Ser Leu Arg His Asp Ile Asp Ile Glu Ala Pro 
        115                 120                 125             


Gln Glu Glu Tyr Tyr Asn Asn Arg Glu Lys Gly Thr Thr Asp Asn Ile 
    130                 135                 140                 


Lys Tyr Gly Arg Arg Cys Cys Leu Gly Thr Val Thr Leu Tyr Leu Ile 
145                 150                 155                 160 


Leu Phe Ile Gly Val Ile Val Tyr Ser Gln Thr Ala Gly Ala Gln Val 
                165                 170                 175     


Val Trp Arg Leu Pro Pro Leu Val Val Pro Val Glu Glu Ser Glu Ile 
            180                 185                 190         


Ile Phe Trp Asp Cys Trp Ala Pro Asp Glu Pro Ala Cys Gln Asp Phe 
        195                 200                 205             


Leu Gly Ala Met Ile His Leu Lys Ala Lys Thr Asn Ile Ser Ile Arg 
    210                 215                 220                 


Glu Gly Pro Thr Leu Gly Asn Trp Ala Arg Glu Ile Trp Ala Thr Leu 
225                 230                 235                 240 


Phe Lys Lys Ala Thr Arg Gln Cys Arg Arg Gly Arg Ile Trp Lys Arg 
                245                 250                 255     


Trp Asn Glu Thr Ile Thr Gly Pro Ser Gly Cys Ala Asn Asn Thr Cys 
            260                 265                 270         


Tyr Asn Val Ser Val Ile Val Pro Asp Tyr Gln Cys Tyr Leu Asp Arg 
        275                 280                 285             


Val Asp Thr Trp Leu Gln Gly Lys Ile Asn Ile Ser Leu Cys Leu Thr 
    290                 295                 300                 


Gly Gly Lys Met Leu Tyr Asn Lys Val Thr Lys Gln Leu Ser Tyr Cys 
305                 310                 315                 320 


Thr Asp Pro Leu Gln Ile Pro Leu Ile Asn Tyr Thr Phe Gly Pro Asn 
                325                 330                 335     


Gln Thr Cys Met Trp Asn Thr Ser Gln Ile Gln Asp Pro Glu Ile Pro 
            340                 345                 350         


Lys Cys Gly Trp Trp Asn Gln Met Ala Tyr Tyr Asn Arg Cys Lys Trp 
        355                 360                 365             


Glu Glu Ala Lys Val Lys Phe His Cys Gln Arg Thr Gln Ser Gln Pro 
    370                 375                 380                 


Gly Ser Trp Arg Arg Ala Ile Ser Ser Trp Lys Gln Arg Asn Arg Trp 
385                 390                 395                 400 


Glu Trp Arg Pro Asp Leu Glu Ser Glu Lys Val Lys Ile Ser Leu Gln 
                405                 410                 415     


Cys Asn Ser Lys Lys Asn Leu Thr Phe Ala Met Arg Ser Ser Gly Asp 
            420                 425                 430         


Tyr Gly Glu Val Thr Gly Ala Trp Ile Glu Phe Gly Cys His Arg Asn 
        435                 440                 445             


Lys Ser Lys His His Ser Glu Ala Arg Phe Arg Ile Arg Cys Arg Trp 
    450                 455                 460                 


Asn Val Gly Ser Asn Thr Ser Leu Ile Asp Thr Cys Gly Asn Thr Gln 
465                 470                 475                 480 


Asp Val Ser Gly Ala Asn Pro Val Asp Cys Thr Met Tyr Ser Asn Lys 
                485                 490                 495     


Met Tyr Asn Cys Ser Leu Gln Asn Gly Phe Thr Met Lys Val Asp Asp 
            500                 505                 510         


Leu Ile Val His Phe Ser Met Thr Lys Ala Val Lys Met Tyr Asn Ile 
        515                 520                 525             


Ala Gly Asn Trp Ser Cys Thr Ser Asp Leu Pro Ser Ser Trp Gly Tyr 
    530                 535                 540                 


Met Asn Cys Asn Cys Thr Asn Ser Ser Ser Ser Tyr Ser Gly Thr Lys 
545                 550                 555                 560 


Met Ala Cys Pro Ser Asn Arg Gly Ile Leu Arg Asn Trp Tyr Asn Pro 
                565                 570                 575     


Val Ala Gly Leu Arg Gln Ser Leu Glu Gln Tyr Gln Val Val Lys Gln 
            580                 585                 590         


Pro Asp Tyr Leu Val Val Pro Glu Glu Val Met Glu Tyr Lys Pro Arg 
        595                 600                 605             


Arg Lys Arg Ala Ala Ile His Val Met Leu Ala Leu Ala Thr Val Leu 
    610                 615                 620                 


Ser Ile Ala Gly Ala Gly Thr Gly Ala Thr Ala Ile Gly Met Val Thr 
625                 630                 635                 640 


Gln Tyr His Gln Val Leu Ala Thr His Gln Glu Ala Ile Glu Lys Val 
                645                 650                 655     


Thr Glu Ala Leu Lys Ile Asn Asn Leu Arg Leu Val Thr Leu Glu His 
            660                 665                 670         


Gln Val Leu Val Ile Gly Leu Lys Val Glu Ala Met Glu Lys Phe Arg 
        675                 680                 685             


Tyr Thr Ala Phe Ala Met Gln Glu Leu Gly Cys Asn Gln Asn Gln Phe 
    690                 695                 700                 


Phe Cys Lys Ile Pro Pro Gly Leu Trp Thr Arg Tyr Asn Met Thr Ile 
705                 710                 715                 720 


Asn Gln Thr Ile Trp Asn His Gly Asn Ile Thr Leu Gly Glu Trp Tyr 
                725                 730                 735     


Asn Lys Thr Lys Asp Leu Gln Gln Lys Phe Tyr Glu Ile Ile Met Asp 
            740                 745                 750         


Ile Glu Gln Asn Asn Val Gln Gly Lys Thr Gly Ile Gln Gln Leu Gln 
        755                 760                 765             


Lys Trp Glu Asp Trp Val Gly Trp Ile Gly Asn Ile Pro Gln Tyr Leu 
    770                 775                 780                 


Lys Gly Leu Leu Gly Gly Ile Leu Gly Ile Gly Leu Gly Val Leu Leu 
785                 790                 795                 800 


Leu Ile Leu Cys Leu Pro Thr Leu Val Asp Cys Ile Arg Asn Cys Ile 
                805                 810                 815     


His Lys Ile Leu Gly Tyr Thr Val Ile Ala Met Pro Glu Val Glu Gly 
            820                 825                 830         


Glu Glu Ile Gln Pro Gln Met Glu Leu Arg Arg Asn Gly Arg Gln Cys 
        835                 840                 845             


Gly Met Ser Glu Lys Glu Glu Glu 
    850                 855     


<210>  384
<211>  855
<212>  PRT
<213>  Artificial sequence

<220>
<223>  Mutated sequence

<400>  384

Met Ala Lys Gly Phe Ala Ala Asn Arg Gln Trp Ile Gly Pro Glu Glu 
1               5                   10                  15      


Ala Glu Glu Leu Leu Asp Phe Asp Ile Ala Thr Gln Met Asn Glu Glu 
            20                  25                  30          


Gly Pro Leu Asn Pro Gly Val Asn Pro Phe Arg Val Pro Gly Ile Thr 
        35                  40                  45              


Glu Gln Glu Lys Gln Asp Tyr Cys Asn Ile Leu Gln Pro Lys Leu Gln 
    50                  55                  60                  


Glu Leu Arg Asn Glu Ile Gln Glu Val Lys Leu Glu Glu Gly Asn Ala 
65                  70                  75                  80  


Gly Lys Phe Arg Arg Ala Arg Phe Leu Arg Tyr Ser Asp Glu Thr Ile 
                85                  90                  95      


Leu Ser Leu Ile His Leu Phe Ile Gly Tyr Cys Thr Tyr Leu Cys Lys 
            100                 105                 110         


Arg Asn Glu Leu Gly Ser Leu Arg His Asp Ile Asp Ile Glu Ala Pro 
        115                 120                 125             


Gln Glu Glu Cys Tyr Asn Asn Lys Glu Lys Gly Thr Thr Asn Asn Ile 
    130                 135                 140                 


Lys Tyr Gly Gly Arg Cys Phe Ile Gly Thr Met Ile Met Tyr Leu Leu 
145                 150                 155                 160 


Ile Phe Ile Gly Ile Ile Ile Tyr Ile Gln Thr Thr Glu Ala Gln Val 
                165                 170                 175     


Val Trp Arg Leu Pro Pro Leu Ile Val Pro Val Lys Glu Ser Glu Ile 
            180                 185                 190         


Ile Phe Trp Asp Cys Trp Ala Pro Glu Glu Pro Ala Cys Gln Asp Phe 
        195                 200                 205             


Leu Gly Ala Met Ile His Leu Lys Ala Ser Thr Asn Ile Ser Ile Gln 
    210                 215                 220                 


Glu Gly Pro Thr Leu Gly Asn Trp Ala Arg Glu Ile Trp Gly Thr Leu 
225                 230                 235                 240 


Phe Lys Lys Ala Thr Arg Gln Cys Arg Arg Gly Arg Ile Trp Lys Arg 
                245                 250                 255     


Trp Asn Glu Thr Ile Thr Gly Pro Leu Gly Cys Ala Asn Asn Thr Cys 
            260                 265                 270         


Tyr Asn Ile Ser Val Ile Val Pro Asp Tyr Gln Cys Tyr Leu Asp Arg 
        275                 280                 285             


Val Asp Thr Trp Leu Gln Gly Lys Val Asn Ile Ser Leu Cys Leu Thr 
    290                 295                 300                 


Gly Gly Lys Met Leu Tyr Asn Lys Asp Thr Lys Gln Leu Ser Tyr Cys 
305                 310                 315                 320 


Thr Asp Pro Leu Gln Ile Pro Leu Ile Asn Tyr Thr Phe Gly Pro Asn 
                325                 330                 335     


Gln Thr Cys Met Trp Asn Thr Ser Gln Ile Gln Asp Pro Glu Ile Pro 
            340                 345                 350         


Lys Cys Gly Trp Trp Asn Gln Ile Ala Tyr Tyr Asn Ser Cys Lys Trp 
        355                 360                 365             


Glu Lys Thr Asp Val Lys Phe His Cys Gln Arg Thr Gln Ser Gln Pro 
    370                 375                 380                 


Gly Ser Trp Ile Arg Ala Ile Ser Ser Trp Arg Gln Arg Asn Arg Trp 
385                 390                 395                 400 


Glu Trp Arg Pro Asp Phe Glu Ser Glu Lys Val Lys Val Ser Leu Gln 
                405                 410                 415     


Cys Asn Ser Thr Lys Asn Leu Thr Phe Ala Met Arg Ser Ser Gly Asp 
            420                 425                 430         


Tyr Gly Glu Val Thr Gly Ala Trp Ile Glu Phe Gly Cys His Arg Lys 
        435                 440                 445             


Lys Ser Lys Leu His Thr Glu Ala Arg Phe Arg Ile Arg Cys Arg Trp 
    450                 455                 460                 


Asn Val Gly Asn Asn Ala Ser Leu Ile Asp Thr Cys Gly Asn Thr Pro 
465                 470                 475                 480 


Asp Val Ser Gly Ala Asn Pro Val Asn Cys Thr Met Tyr Ala Asn Lys 
                485                 490                 495     


Met Tyr Asn Cys Trp Leu Gln Asn Gly Phe Thr Ile Lys Val Asp Asp 
            500                 505                 510         


Leu Ile Met His Phe Asn Met Thr Lys Ala Val Glu Met Tyr Asn Ile 
        515                 520                 525             


Ala Gly Asn Trp Ser Cys Thr Ser Asp Leu Pro Pro Thr Trp Gly Tyr 
    530                 535                 540                 


Met Lys Cys Asn Cys Thr Asn Asn Ser Asp Asp Thr Arg Gly Lys Met 
545                 550                 555                 560 


Ala Cys Pro Arg Thr Gln Gly Ile Leu Arg Asn Trp Tyr Asn Pro Val 
                565                 570                 575     


Ala Gly Leu Arg Gln Ser Leu Glu Lys Tyr Gln Val Val Lys Gln Pro 
            580                 585                 590         


Asp Tyr Leu Val Val Pro Gly Glu Val Met Glu Tyr Lys Pro Arg Arg 
        595                 600                 605             


Lys Arg Ala Ala Ile His Val Met Leu Ala Leu Ala Thr Val Leu Ser 
    610                 615                 620                 


Met Ala Gly Ala Gly Thr Gly Ala Thr Ala Ile Gly Met Val Thr Gln 
625                 630                 635                 640 


Tyr His Gln Val Leu Ala Thr His Gln Glu Ala Ile Glu Lys Val Thr 
                645                 650                 655     


Glu Ala Leu Lys Ile Asn Asn Leu Arg Leu Val Thr Leu Glu His Gln 
            660                 665                 670         


Val Leu Val Ile Gly Leu Lys Val Glu Ala Met Glu Lys Arg Leu Tyr 
        675                 680                 685             


Thr Ala Phe Ala Met Gln Glu Leu Gly Cys Asn Gln Asn Gln Phe Phe 
    690                 695                 700                 


Cys Lys Val Pro Pro Gln Leu Trp Lys Arg Tyr Asn Met Thr Ile Asn 
705                 710                 715                 720 


Gln Thr Ile Trp Asn His Gly Asn Ile Thr Leu Gly Glu Trp Tyr Asn 
                725                 730                 735     


Gln Thr Lys Asp Leu Gln Gln Lys Phe Tyr Glu Ile Ile Met Asp Ile 
            740                 745                 750         


Glu Gln Asn Asn Val Gln Gly Lys Thr Gly Ile Gln Gln Leu Gln Arg 
        755                 760                 765             


Trp Glu Asp Trp Val Gly Trp Ile Gly Asn Ile Pro Gln Tyr Leu Lys 
    770                 775                 780                 


Gly Leu Leu Gly Gly Ile Leu Gly Ile Gly Leu Gly Val Leu Leu Leu 
785                 790                 795                 800 


Ile Leu Cys Leu Pro Thr Leu Val Asp Cys Ile Arg Asn Cys Ile His 
                805                 810                 815     


Lys Ile Leu Gly Tyr Thr Val Ile Ala Met Pro Glu Val Glu Glu Glu 
            820                 825                 830         


Glu Ile Gln Gln Gln Met Glu Leu Arg Arg Asn Gly Arg Gln Cys Gly 
        835                 840                 845             


Met Ser Glu Lys Glu Glu Glu 
    850                 855 


<210>  385
<211>  855
<212>  PRT
<213>  Artificial sequence

<220>
<223>  Mutated sequence

<400>  385

Met Ala Lys Gly Phe Ala Ala Asn Arg Gln Trp Ile Gly Pro Glu Glu 
1               5                   10                  15      


Ala Glu Glu Leu Leu Asp Phe Asp Ile Ala Thr Gln Met Asn Glu Glu 
            20                  25                  30          


Gly Pro Leu Asn Pro Gly Val Asn Pro Phe Arg Val Pro Gly Ile Thr 
        35                  40                  45              


Glu Gln Glu Lys Gln Asp Tyr Cys Asn Ile Leu Gln Pro Lys Leu Gln 
    50                  55                  60                  


Glu Leu Arg Asn Glu Ile Gln Glu Val Lys Leu Glu Glu Gly Asn Ala 
65                  70                  75                  80  


Gly Lys Phe Arg Arg Ala Arg Phe Leu Arg Tyr Ser Asp Glu Thr Ile 
                85                  90                  95      


Leu Ser Leu Ile His Leu Phe Ile Gly Tyr Cys Thr Tyr Leu Cys Lys 
            100                 105                 110         


Arg Asn Glu Leu Gly Ser Leu Arg His Asp Ile Asp Ile Glu Ala Pro 
        115                 120                 125             


Gln Glu Glu Cys Tyr Asn Asn Lys Glu Lys Gly Thr Thr Asn Asn Ile 
    130                 135                 140                 


Lys Tyr Gly Gly Arg Cys Phe Ile Gly Thr Met Ile Met Tyr Leu Leu 
145                 150                 155                 160 


Ile Phe Ile Gly Ile Ile Ile Tyr Ile Gln Thr Thr Glu Ala Gln Val 
                165                 170                 175     


Val Trp Arg Leu Pro Pro Leu Ile Val Pro Val Lys Glu Ser Glu Ile 
            180                 185                 190         


Ile Phe Trp Asp Cys Trp Ala Pro Glu Glu Pro Ala Cys Gln Asp Phe 
        195                 200                 205             


Leu Gly Ala Met Ile His Leu Lys Ala Ser Thr Asn Ile Ser Ile Gln 
    210                 215                 220                 


Glu Gly Pro Thr Leu Gly Asn Trp Ala Arg Glu Ile Trp Gly Thr Leu 
225                 230                 235                 240 


Phe Lys Lys Ala Thr Arg Gln Cys Arg Arg Gly Arg Ile Trp Lys Arg 
                245                 250                 255     


Trp Asn Glu Thr Ile Thr Gly Pro Leu Gly Cys Ala Asn Asn Thr Cys 
            260                 265                 270         


Tyr Asn Ile Ser Val Ile Val Pro Asp Tyr Gln Cys Tyr Leu Asp Arg 
        275                 280                 285             


Val Asp Thr Trp Leu Gln Gly Lys Val Asn Ile Ser Leu Cys Leu Thr 
    290                 295                 300                 


Gly Gly Lys Met Leu Tyr Asn Lys Asp Thr Lys Gln Leu Ser Tyr Cys 
305                 310                 315                 320 


Thr Asp Pro Leu Gln Ile Pro Leu Ile Asn Tyr Thr Phe Gly Pro Asn 
                325                 330                 335     


Gln Thr Cys Met Trp Asn Thr Ser Gln Ile Gln Asp Pro Glu Ile Pro 
            340                 345                 350         


Lys Cys Gly Trp Trp Asn Gln Ile Ala Tyr Tyr Asn Ser Cys Lys Trp 
        355                 360                 365             


Glu Lys Thr Asp Val Lys Phe His Cys Gln Arg Thr Gln Ser Gln Pro 
    370                 375                 380                 


Gly Ser Trp Ile Arg Ala Ile Ser Ser Trp Arg Gln Arg Asn Arg Trp 
385                 390                 395                 400 


Glu Trp Arg Pro Asp Phe Glu Ser Glu Lys Val Lys Val Ser Leu Gln 
                405                 410                 415     


Cys Asn Ser Thr Lys Asn Leu Thr Phe Ala Met Arg Ser Ser Gly Asp 
            420                 425                 430         


Tyr Gly Glu Val Thr Gly Ala Trp Ile Glu Phe Gly Cys His Arg Lys 
        435                 440                 445             


Lys Ser Lys Leu His Thr Glu Ala Arg Phe Arg Ile Arg Cys Arg Trp 
    450                 455                 460                 


Asn Val Gly Asn Asn Ala Ser Leu Ile Asp Thr Cys Gly Asn Thr Pro 
465                 470                 475                 480 


Asp Val Ser Gly Ala Asn Pro Val Asn Cys Thr Met Tyr Ala Asn Lys 
                485                 490                 495     


Met Tyr Asn Cys Trp Leu Gln Asn Gly Phe Thr Ile Lys Val Asp Asp 
            500                 505                 510         


Leu Ile Met His Phe Asn Met Thr Lys Ala Val Glu Met Tyr Asn Ile 
        515                 520                 525             


Ala Gly Asn Trp Ser Cys Thr Ser Asp Leu Pro Pro Thr Trp Gly Tyr 
    530                 535                 540                 


Met Lys Cys Asn Cys Thr Asn Asn Ser Asp Asp Thr Arg Gly Lys Met 
545                 550                 555                 560 


Ala Cys Pro Arg Thr Gln Gly Ile Leu Arg Asn Trp Tyr Asn Pro Val 
                565                 570                 575     


Ala Gly Leu Arg Gln Ser Leu Glu Lys Tyr Gln Val Val Lys Gln Pro 
            580                 585                 590         


Asp Tyr Leu Val Val Pro Gly Glu Val Met Glu Tyr Lys Pro Arg Arg 
        595                 600                 605             


Lys Arg Ala Ala Ile His Val Met Leu Ala Leu Ala Thr Val Leu Ser 
    610                 615                 620                 


Met Ala Gly Ala Gly Thr Gly Ala Thr Ala Ile Gly Met Val Thr Gln 
625                 630                 635                 640 


Tyr His Gln Val Leu Ala Thr His Gln Glu Ala Ile Glu Lys Val Thr 
                645                 650                 655     


Glu Ala Leu Lys Ile Asn Asn Leu Arg Leu Val Thr Leu Glu His Gln 
            660                 665                 670         


Val Leu Val Ile Gly Leu Lys Val Glu Ala Met Glu Lys Phe Arg Tyr 
        675                 680                 685             


Thr Ala Phe Ala Met Gln Glu Leu Gly Cys Asn Gln Asn Gln Phe Phe 
    690                 695                 700                 


Cys Lys Val Pro Pro Gln Leu Trp Lys Arg Tyr Asn Met Thr Ile Asn 
705                 710                 715                 720 


Gln Thr Ile Trp Asn His Gly Asn Ile Thr Leu Gly Glu Trp Tyr Asn 
                725                 730                 735     


Gln Thr Lys Asp Leu Gln Gln Lys Phe Tyr Glu Ile Ile Met Asp Ile 
            740                 745                 750         


Glu Gln Asn Asn Val Gln Gly Lys Thr Gly Ile Gln Gln Leu Gln Arg 
        755                 760                 765             


Trp Glu Asp Trp Val Gly Trp Ile Gly Asn Ile Pro Gln Tyr Leu Lys 
    770                 775                 780                 


Gly Leu Leu Gly Gly Ile Leu Gly Ile Gly Leu Gly Val Leu Leu Leu 
785                 790                 795                 800 


Ile Leu Cys Leu Pro Thr Leu Val Asp Cys Ile Arg Asn Cys Ile His 
                805                 810                 815     


Lys Ile Leu Gly Tyr Thr Val Ile Ala Met Pro Glu Val Glu Glu Glu 
            820                 825                 830         


Glu Ile Gln Gln Gln Met Glu Leu Arg Arg Asn Gly Arg Gln Cys Gly 
        835                 840                 845             


Met Ser Glu Lys Glu Glu Glu 
    850                 855 


<210>  386
<211>  853
<212>  PRT
<213>  Artificial sequence

<220>
<223>  Mutated sequence

<400>  386

Met Ala Glu Gly Phe Ala Ala Asn Arg Gln Trp Ile Gly Pro Glu Glu 
1               5                   10                  15      


Ala Glu Glu Leu Leu Asp Phe Asp Ile Ala Thr Gln Met Asn Glu Glu 
            20                  25                  30          


Gly Pro Leu Asn Pro Gly Ile Asn Pro Phe Arg Val Pro Gly Ile Thr 
        35                  40                  45              


Glu Ile Glu Lys Gln Ala Tyr Cys Lys Ile Leu Gln Pro Arg Leu Gln 
    50                  55                  60                  


Ala Leu Arg Asn Glu Ile Gln Glu Val Lys Leu Glu Glu Gly Asn Ala 
65                  70                  75                  80  


Gly Lys Phe Arg Arg Ala Arg Phe Leu Arg Tyr Ser Asp Val Ala Ile 
                85                  90                  95      


Leu Ser Leu Ile His Val Phe Ile Gly Tyr Cys Thr Tyr Leu Cys Asn 
            100                 105                 110         


Gln Gln Lys Leu Gly Ser Leu Arg His Asp Ile Asp Ile Glu Ala Pro 
        115                 120                 125             


Gln Glu Glu Tyr Tyr Ser Asn Asn Glu Lys Gly Thr Thr Asp Asn Ile 
    130                 135                 140                 


Lys Tyr Gly Arg Arg Cys Val Ile Gly Thr Val Ala Leu Tyr Leu Leu 
145                 150                 155                 160 


Ile Cys Thr Gly Ile Ile Ile Tyr Thr Arg Thr Ala Thr Ala Gln Val 
                165                 170                 175     


Val Trp Arg Leu Pro Pro Leu Val Val Pro Val Glu Glu Ser Glu Val 
            180                 185                 190         


Ile Phe Trp Asp Cys Trp Ala Pro Glu Glu Pro Ala Cys Gln Asp Phe 
        195                 200                 205             


Leu Gly Ala Met Ile His Leu Lys Ala Ser Thr Asn Ile Ser Ile Gln 
    210                 215                 220                 


Glu Gly Pro Thr Leu Gly Asn Trp Ala Arg Glu Ile Trp Gly Thr Leu 
225                 230                 235                 240 


Phe Lys Lys Ala Thr Arg Gln Cys Arg Arg Gly Arg Ile Trp Arg Arg 
                245                 250                 255     


Trp Asn Glu Thr Ile Thr Gly Pro Leu Gly Cys Ala Asn Asn Thr Cys 
            260                 265                 270         


Tyr Asn Ile Ser Val Ile Val Pro Asp Tyr Gln Cys Tyr Leu Asp Arg 
        275                 280                 285             


Val Asp Thr Trp Leu Gln Gly Lys Ile Asn Ile Ser Leu Cys Leu Thr 
    290                 295                 300                 


Gly Gly Lys Met Leu Tyr Asn Arg Tyr Thr Lys Gln Leu Ser Tyr Cys 
305                 310                 315                 320 


Thr Asp Pro Leu Gln Ile Pro Leu Ile Asn Tyr Thr Phe Gly Pro Asn 
                325                 330                 335     


Gln Thr Cys Met Trp Asn Thr Ser Gln Ile Gln Asp Pro Glu Ile Pro 
            340                 345                 350         


Lys Cys Gly Trp Trp Asn Gln Arg Ala Tyr Tyr Asn Ser Cys Arg Trp 
        355                 360                 365             


Glu Ser Thr Asp Val Lys Phe His Cys Gln Arg Thr Gln Ser Gln Pro 
    370                 375                 380                 


Gly Ser Trp Leu Arg Ala Ile Ser Ser Trp Arg Gln Arg Asn Arg Trp 
385                 390                 395                 400 


Glu Trp Arg Pro Asp Phe Glu Ser Glu Lys Val Lys Val Ser Leu Gln 
                405                 410                 415     


Cys Asn Ser Thr Lys Asn Leu Thr Phe Ala Met Arg Ser Ser Gly Asp 
            420                 425                 430         


Tyr Gly Asp Val Thr Gly Ala Trp Ile Glu Phe Gly Cys His Arg Asn 
        435                 440                 445             


Lys Ser Arg Leu His Thr Glu Ala Arg Phe Arg Ile Arg Cys Arg Trp 
    450                 455                 460                 


Asn Val Gly Asp Asn Thr Ser Leu Ile Asp Thr Cys Gly Lys Thr Gln 
465                 470                 475                 480 


Asn Ile Ala Gly Ala Asn Pro Val Asp Cys Thr Met Tyr Val Asn Arg 
                485                 490                 495     


Met Tyr Asn Cys Ser Leu Gln Asn Gly Phe Thr Met Lys Val Asp Asp 
            500                 505                 510         


Leu Ile Met His Phe Asn Met Thr Lys Ala Val Glu Met Tyr Asn Ile 
        515                 520                 525             


Ala Gly Asn Trp Ser Cys Thr Ser Asn Leu Pro Pro Thr Trp Gly Tyr 
    530                 535                 540                 


Ile Asn Cys Asn Cys Thr Asn Ser Ser Asp Ser Asn Lys Met Ala Cys 
545                 550                 555                 560 


Pro Ser Ser Gln Gly Ile Leu Arg Asn Trp Tyr Asn Pro Val Ala Gly 
                565                 570                 575     


Leu Arg Gln Ser Leu Glu Lys Tyr Gln Val Val Lys Gln Pro Asp Tyr 
            580                 585                 590         


Leu Val Val Pro Gly Glu Val Met Glu Tyr Lys Pro Arg Arg Lys Arg 
        595                 600                 605             


Ala Ala Ile His Val Met Leu Ala Leu Ala Thr Ile Leu Ser Met Ala 
    610                 615                 620                 


Gly Ala Gly Thr Gly Ala Thr Ala Ile Gly Met Val Thr Gln Tyr His 
625                 630                 635                 640 


Gln Val Leu Ala Thr His Gln Glu Ala Ile Glu Lys Val Thr Glu Ala 
                645                 650                 655     


Leu Lys Val Asn Asn Leu Arg Leu Ile Thr Leu Glu His Gln Val Leu 
            660                 665                 670         


Val Ile Gly Leu Lys Val Glu Ala Met Glu Lys Arg Leu Tyr Thr Ala 
        675                 680                 685             


Phe Ala Met Gln Glu Leu Gly Cys Asn Gln Asn Gln Phe Phe Cys Lys 
    690                 695                 700                 


Val Pro Pro Glu Leu Trp Lys Arg Tyr Asn Met Thr Ile Asn Gln Thr 
705                 710                 715                 720 


Ile Trp Asn His Gly Asn Ile Thr Leu Gly Glu Trp Tyr Asn Gln Thr 
                725                 730                 735     


Lys Gly Leu Gln Gln Lys Phe Tyr Glu Ile Ile Met Asp Ile Glu Gln 
            740                 745                 750         


Asn Ser Val Gln Gly Lys Lys Gly Ile Gln Gln Leu Gln Glu Trp Glu 
        755                 760                 765             


Asp Trp Ile Gly Trp Ile Gly Asn Ile Pro Gln Tyr Leu Lys Gly Leu 
    770                 775                 780                 


Leu Gly Gly Ile Leu Gly Ile Gly Leu Gly Val Leu Leu Leu Ile Leu 
785                 790                 795                 800 


Cys Leu Pro Thr Leu Val Asp Cys Ile Arg Asn Cys Ile His Lys Ile 
                805                 810                 815     


Leu Gly Tyr Thr Val Ile Ala Met Pro Glu Val Glu Gly Glu Glu Ile 
            820                 825                 830         


Gln Pro Gln Met Glu Leu Arg Arg Asn Gly Arg Gln Cys Gly Met Ser 
        835                 840                 845             


Glu Lys Glu Glu Glu 
    850             


<210>  387
<211>  853
<212>  PRT
<213>  Artificial sequence

<220>
<223>  Mutated sequence

<400>  387

Met Ala Glu Gly Phe Ala Ala Asn Arg Gln Trp Ile Gly Pro Glu Glu 
1               5                   10                  15      


Ala Glu Glu Leu Leu Asp Phe Asp Ile Ala Thr Gln Met Asn Glu Glu 
            20                  25                  30          


Gly Pro Leu Asn Pro Gly Ile Asn Pro Phe Arg Val Pro Gly Ile Thr 
        35                  40                  45              


Glu Ile Glu Lys Gln Ala Tyr Cys Lys Ile Leu Gln Pro Arg Leu Gln 
    50                  55                  60                  


Ala Leu Arg Asn Glu Ile Gln Glu Val Lys Leu Glu Glu Gly Asn Ala 
65                  70                  75                  80  


Gly Lys Phe Arg Arg Ala Arg Phe Leu Arg Tyr Ser Asp Val Ala Ile 
                85                  90                  95      


Leu Ser Leu Ile His Val Phe Ile Gly Tyr Cys Thr Tyr Leu Cys Asn 
            100                 105                 110         


Gln Gln Lys Leu Gly Ser Leu Arg His Asp Ile Asp Ile Glu Ala Pro 
        115                 120                 125             


Gln Glu Glu Tyr Tyr Ser Asn Asn Glu Lys Gly Thr Thr Asp Asn Ile 
    130                 135                 140                 


Lys Tyr Gly Arg Arg Cys Val Ile Gly Thr Val Ala Leu Tyr Leu Leu 
145                 150                 155                 160 


Ile Cys Thr Gly Ile Ile Ile Tyr Thr Arg Thr Ala Thr Ala Gln Val 
                165                 170                 175     


Val Trp Arg Leu Pro Pro Leu Val Val Pro Val Glu Glu Ser Glu Val 
            180                 185                 190         


Ile Phe Trp Asp Cys Trp Ala Pro Glu Glu Pro Ala Cys Gln Asp Phe 
        195                 200                 205             


Leu Gly Ala Met Ile His Leu Lys Ala Ser Thr Asn Ile Ser Ile Gln 
    210                 215                 220                 


Glu Gly Pro Thr Leu Gly Asn Trp Ala Arg Glu Ile Trp Gly Thr Leu 
225                 230                 235                 240 


Phe Lys Lys Ala Thr Arg Gln Cys Arg Arg Gly Arg Ile Trp Arg Arg 
                245                 250                 255     


Trp Asn Glu Thr Ile Thr Gly Pro Leu Gly Cys Ala Asn Asn Thr Cys 
            260                 265                 270         


Tyr Asn Ile Ser Val Ile Val Pro Asp Tyr Gln Cys Tyr Leu Asp Arg 
        275                 280                 285             


Val Asp Thr Trp Leu Gln Gly Lys Ile Asn Ile Ser Leu Cys Leu Thr 
    290                 295                 300                 


Gly Gly Lys Met Leu Tyr Asn Arg Tyr Thr Lys Gln Leu Ser Tyr Cys 
305                 310                 315                 320 


Thr Asp Pro Leu Gln Ile Pro Leu Ile Asn Tyr Thr Phe Gly Pro Asn 
                325                 330                 335     


Gln Thr Cys Met Trp Asn Thr Ser Gln Ile Gln Asp Pro Glu Ile Pro 
            340                 345                 350         


Lys Cys Gly Trp Trp Asn Gln Arg Ala Tyr Tyr Asn Ser Cys Arg Trp 
        355                 360                 365             


Glu Ser Thr Asp Val Lys Phe His Cys Gln Arg Thr Gln Ser Gln Pro 
    370                 375                 380                 


Gly Ser Trp Leu Arg Ala Ile Ser Ser Trp Arg Gln Arg Asn Arg Trp 
385                 390                 395                 400 


Glu Trp Arg Pro Asp Phe Glu Ser Glu Lys Val Lys Val Ser Leu Gln 
                405                 410                 415     


Cys Asn Ser Thr Lys Asn Leu Thr Phe Ala Met Arg Ser Ser Gly Asp 
            420                 425                 430         


Tyr Gly Asp Val Thr Gly Ala Trp Ile Glu Phe Gly Cys His Arg Asn 
        435                 440                 445             


Lys Ser Arg Leu His Thr Glu Ala Arg Phe Arg Ile Arg Cys Arg Trp 
    450                 455                 460                 


Asn Val Gly Asp Asn Thr Ser Leu Ile Asp Thr Cys Gly Lys Thr Gln 
465                 470                 475                 480 


Asn Ile Ala Gly Ala Asn Pro Val Asp Cys Thr Met Tyr Val Asn Arg 
                485                 490                 495     


Met Tyr Asn Cys Ser Leu Gln Asn Gly Phe Thr Met Lys Val Asp Asp 
            500                 505                 510         


Leu Ile Met His Phe Asn Met Thr Lys Ala Val Glu Met Tyr Asn Ile 
        515                 520                 525             


Ala Gly Asn Trp Ser Cys Thr Ser Asn Leu Pro Pro Thr Trp Gly Tyr 
    530                 535                 540                 


Ile Asn Cys Asn Cys Thr Asn Ser Ser Asp Ser Asn Lys Met Ala Cys 
545                 550                 555                 560 


Pro Ser Ser Gln Gly Ile Leu Arg Asn Trp Tyr Asn Pro Val Ala Gly 
                565                 570                 575     


Leu Arg Gln Ser Leu Glu Lys Tyr Gln Val Val Lys Gln Pro Asp Tyr 
            580                 585                 590         


Leu Val Val Pro Gly Glu Val Met Glu Tyr Lys Pro Arg Arg Lys Arg 
        595                 600                 605             


Ala Ala Ile His Val Met Leu Ala Leu Ala Thr Ile Leu Ser Met Ala 
    610                 615                 620                 


Gly Ala Gly Thr Gly Ala Thr Ala Ile Gly Met Val Thr Gln Tyr His 
625                 630                 635                 640 


Gln Val Leu Ala Thr His Gln Glu Ala Ile Glu Lys Val Thr Glu Ala 
                645                 650                 655     


Leu Lys Val Asn Asn Leu Arg Leu Ile Thr Leu Glu His Gln Val Leu 
            660                 665                 670         


Val Ile Gly Leu Lys Val Glu Ala Met Glu Lys Phe Arg Tyr Thr Ala 
        675                 680                 685             


Phe Ala Met Gln Glu Leu Gly Cys Asn Gln Asn Gln Phe Phe Cys Lys 
    690                 695                 700                 


Val Pro Pro Glu Leu Trp Lys Arg Tyr Asn Met Thr Ile Asn Gln Thr 
705                 710                 715                 720 


Ile Trp Asn His Gly Asn Ile Thr Leu Gly Glu Trp Tyr Asn Gln Thr 
                725                 730                 735     


Lys Gly Leu Gln Gln Lys Phe Tyr Glu Ile Ile Met Asp Ile Glu Gln 
            740                 745                 750         


Asn Ser Val Gln Gly Lys Lys Gly Ile Gln Gln Leu Gln Glu Trp Glu 
        755                 760                 765             


Asp Trp Ile Gly Trp Ile Gly Asn Ile Pro Gln Tyr Leu Lys Gly Leu 
    770                 775                 780                 


Leu Gly Gly Ile Leu Gly Ile Gly Leu Gly Val Leu Leu Leu Ile Leu 
785                 790                 795                 800 


Cys Leu Pro Thr Leu Val Asp Cys Ile Arg Asn Cys Ile His Lys Ile 
                805                 810                 815     


Leu Gly Tyr Thr Val Ile Ala Met Pro Glu Val Glu Gly Glu Glu Ile 
            820                 825                 830         


Gln Pro Gln Met Glu Leu Arg Arg Asn Gly Arg Gln Cys Gly Met Ser 
        835                 840                 845             


Glu Lys Glu Glu Glu 
    850             


<210>  388
<211>  827
<212>  PRT
<213>  Artificial sequence

<220>
<223>  Mutated sequence

<400>  388

Met Asn Glu Glu Gly Pro Leu Asn Pro Gly Ile Asn Pro Phe Arg Val 
1               5                   10                  15      


Pro Gly Ile Thr Glu Thr Glu Lys Gln Asp Tyr Cys Asn Met Leu Gln 
            20                  25                  30          


Pro Lys Leu Gln Ala Leu Arg Asn Glu Ile Gln Glu Val Lys Leu Glu 
        35                  40                  45              


Glu Gly Asn Ala Gly Lys Phe Arg Arg Ala Arg Phe Leu Arg Tyr Ser 
    50                  55                  60                  


Asp Glu Thr Ile Leu Ser Leu Ile His Leu Phe Ile Gly Tyr Cys Thr 
65                  70                  75                  80  


Tyr Leu Leu Asn Arg Lys Glu Leu Gly Ser Leu Arg His Asp Ile Asp 
                85                  90                  95      


Ile Glu Ala Pro Gln Glu Glu Cys Tyr Ser Ser Arg Glu Gln Ser Ile 
            100                 105                 110         


Thr Asp Asn Ile Lys Tyr Gly Lys Arg Cys Phe Ile Gly Thr Ala Gly 
        115                 120                 125             


Leu Tyr Leu Leu Leu Phe Ile Gly Val Gly Ile Tyr Leu Gly Thr Ala 
    130                 135                 140                 


Lys Ala Gln Val Val Trp Arg Leu Pro Pro Leu Val Val Pro Val Glu 
145                 150                 155                 160 


Glu Ser Glu Ile Ile Phe Trp Asp Cys Trp Ala Pro Glu Glu Pro Ala 
                165                 170                 175     


Cys Gln Asp Phe Leu Gly Ala Met Ile His Leu Lys Ala Ser Thr Asn 
            180                 185                 190         


Ile Ser Ile Gln Glu Gly Pro Thr Leu Gly Asn Trp Ala Lys Glu Ile 
        195                 200                 205             


Trp Gly Thr Leu Phe Lys Lys Ala Thr Arg Gln Cys Arg Arg Gly Arg 
    210                 215                 220                 


Ile Trp Lys Arg Trp Asn Glu Thr Ile Ser Gly Pro Leu Gly Cys Ala 
225                 230                 235                 240 


Asn Asn Thr Cys Tyr Asn Ile Ser Val Ile Val Pro Asp Tyr Gln Cys 
                245                 250                 255     


Tyr Leu Asp Arg Val Asp Thr Trp Leu Gln Gly Lys Val Asn Val Ser 
            260                 265                 270         


Leu Cys Leu Thr Gly Gly Lys Ile Leu Tyr Asn Lys Tyr Thr Lys Gln 
        275                 280                 285             


Leu Ser Tyr Cys Thr Asp Pro Leu Gln Ile Pro Leu Ile Ser Tyr Thr 
    290                 295                 300                 


Phe Gly Pro Asn Gln Thr Cys Met Trp Asp Thr Ser Gln Ile Gln Asp 
305                 310                 315                 320 


Pro Glu Ile Pro Lys Cys Gly Trp Trp Asn Gln Ile Ala Tyr Tyr Asn 
                325                 330                 335     


Ser Cys Arg Trp Glu Ser Thr Asp Val Lys Phe His Cys Gln Arg Thr 
            340                 345                 350         


Gln Ser Gln Pro Gly Leu Trp Leu Arg Ala Ile Ser Ser Trp Lys Gln 
        355                 360                 365             


Arg Asn Arg Trp Glu Trp Arg Pro Asp Phe Glu Ser Glu Lys Ala Lys 
    370                 375                 380                 


Val Ser Leu Gln Cys Asn Ser Thr Lys Asn Leu Thr Phe Ala Met Arg 
385                 390                 395                 400 


Ser Ser Gly Asp Tyr Gly Glu Val Thr Gly Ala Trp Ile Glu Phe Gly 
                405                 410                 415     


Cys His Arg Asn Lys Ser Lys Leu His Thr Glu Ala Arg Phe Arg Ile 
            420                 425                 430         


Arg Cys Arg Trp Asn Val Gly Asp Asn Thr Ser Leu Ile Asp Thr Cys 
        435                 440                 445             


Gly Glu Thr Gln Asn Val Ser Gly Ala Asn Pro Val Asp Cys Thr Met 
    450                 455                 460                 


Tyr Ala Asn Arg Met Tyr Asn Cys Ser Leu Gln Asn Gly Phe Thr Met 
465                 470                 475                 480 


Lys Val Asp Asp Leu Ile Met His Phe Asn Met Thr Lys Ala Val Glu 
                485                 490                 495     


Met Tyr Asp Ile Ala Gly Asn Trp Ser Cys Thr Ser Asp Leu Pro Pro 
            500                 505                 510         


Thr Trp Gly Tyr Met Asn Cys Asn Cys Thr Asn Ser Ser Ser Thr Asn 
        515                 520                 525             


Ser Val Lys Met Ala Cys Pro Lys Asn Gln Gly Ile Leu Arg Asn Trp 
    530                 535                 540                 


Tyr Asn Pro Val Ala Gly Leu Arg Gln Ser Leu Glu Lys Tyr Gln Val 
545                 550                 555                 560 


Val Lys Gln Pro Asp Tyr Leu Val Val Pro Gly Glu Val Met Glu Tyr 
                565                 570                 575     


Lys Pro Arg Arg Lys Arg Ala Ala Ile His Val Met Leu Ala Leu Ala 
            580                 585                 590         


Thr Val Leu Ser Met Ala Gly Ala Gly Thr Gly Ala Thr Ala Ile Gly 
        595                 600                 605             


Met Val Thr Gln Tyr His Gln Val Leu Ala Thr His Gln Glu Thr Ile 
    610                 615                 620                 


Glu Lys Val Thr Glu Ala Leu Lys Ile Asn Asn Leu Arg Leu Val Thr 
625                 630                 635                 640 


Leu Glu His Gln Val Leu Val Ile Gly Leu Lys Val Glu Ala Met Glu 
                645                 650                 655     


Lys Arg Leu Tyr Thr Ala Phe Ala Met Gln Glu Leu Gly Cys Asn Gln 
            660                 665                 670         


Asn Gln Phe Phe Cys Lys Val Pro Pro Glu Leu Trp Lys Arg Tyr Asn 
        675                 680                 685             


Met Thr Ile Asn Gln Thr Ile Trp Asn His Gly Asn Ile Thr Leu Gly 
    690                 695                 700                 


Glu Trp Tyr Asn Gln Thr Lys Glu Leu Gln Gln Lys Phe Tyr Glu Ile 
705                 710                 715                 720 


Ile Met Asn Ile Glu Gln Asn Asn Val Gln Val Lys Lys Gly Leu Gln 
                725                 730                 735     


Gln Leu Gln Glu Trp Glu Asp Trp Val Gly Trp Ile Gly Asn Ile Pro 
            740                 745                 750         


Gln Tyr Leu Lys Gly Leu Leu Gly Gly Ile Leu Gly Ile Gly Ile Gly 
        755                 760                 765             


Val Leu Leu Leu Ile Leu Cys Leu Pro Thr Leu Val Asp Cys Ile Arg 
    770                 775                 780                 


Asn Cys Ile Ser Lys Val Leu Gly Tyr Thr Val Ile Ala Met Pro Glu 
785                 790                 795                 800 


Ile Gly Asp Glu Glu Glu Thr Val Gln Met Glu Leu Arg Lys Asn Gly 
                805                 810                 815     


Arg Gln Cys Gly Met Ser Glu Lys Glu Glu Glu 
            820                 825         


<210>  389
<211>  827
<212>  PRT
<213>  Artificial sequence

<220>
<223>  Mutated sequence

<400>  389

Met Asn Glu Glu Gly Pro Leu Asn Pro Gly Ile Asn Pro Phe Arg Val 
1               5                   10                  15      


Pro Gly Ile Thr Glu Thr Glu Lys Gln Asp Tyr Cys Asn Met Leu Gln 
            20                  25                  30          


Pro Lys Leu Gln Ala Leu Arg Asn Glu Ile Gln Glu Val Lys Leu Glu 
        35                  40                  45              


Glu Gly Asn Ala Gly Lys Phe Arg Arg Ala Arg Phe Leu Arg Tyr Ser 
    50                  55                  60                  


Asp Glu Thr Ile Leu Ser Leu Ile His Leu Phe Ile Gly Tyr Cys Thr 
65                  70                  75                  80  


Tyr Leu Leu Asn Arg Lys Glu Leu Gly Ser Leu Arg His Asp Ile Asp 
                85                  90                  95      


Ile Glu Ala Pro Gln Glu Glu Cys Tyr Ser Ser Arg Glu Gln Ser Ile 
            100                 105                 110         


Thr Asp Asn Ile Lys Tyr Gly Lys Arg Cys Phe Ile Gly Thr Ala Gly 
        115                 120                 125             


Leu Tyr Leu Leu Leu Phe Ile Gly Val Gly Ile Tyr Leu Gly Thr Ala 
    130                 135                 140                 


Lys Ala Gln Val Val Trp Arg Leu Pro Pro Leu Val Val Pro Val Glu 
145                 150                 155                 160 


Glu Ser Glu Ile Ile Phe Trp Asp Cys Trp Ala Pro Glu Glu Pro Ala 
                165                 170                 175     


Cys Gln Asp Phe Leu Gly Ala Met Ile His Leu Lys Ala Ser Thr Asn 
            180                 185                 190         


Ile Ser Ile Gln Glu Gly Pro Thr Leu Gly Asn Trp Ala Lys Glu Ile 
        195                 200                 205             


Trp Gly Thr Leu Phe Lys Lys Ala Thr Arg Gln Cys Arg Arg Gly Arg 
    210                 215                 220                 


Ile Trp Lys Arg Trp Asn Glu Thr Ile Ser Gly Pro Leu Gly Cys Ala 
225                 230                 235                 240 


Asn Asn Thr Cys Tyr Asn Ile Ser Val Ile Val Pro Asp Tyr Gln Cys 
                245                 250                 255     


Tyr Leu Asp Arg Val Asp Thr Trp Leu Gln Gly Lys Val Asn Val Ser 
            260                 265                 270         


Leu Cys Leu Thr Gly Gly Lys Ile Leu Tyr Asn Lys Tyr Thr Lys Gln 
        275                 280                 285             


Leu Ser Tyr Cys Thr Asp Pro Leu Gln Ile Pro Leu Ile Ser Tyr Thr 
    290                 295                 300                 


Phe Gly Pro Asn Gln Thr Cys Met Trp Asp Thr Ser Gln Ile Gln Asp 
305                 310                 315                 320 


Pro Glu Ile Pro Lys Cys Gly Trp Trp Asn Gln Ile Ala Tyr Tyr Asn 
                325                 330                 335     


Ser Cys Arg Trp Glu Ser Thr Asp Val Lys Phe His Cys Gln Arg Thr 
            340                 345                 350         


Gln Ser Gln Pro Gly Leu Trp Leu Arg Ala Ile Ser Ser Trp Lys Gln 
        355                 360                 365             


Arg Asn Arg Trp Glu Trp Arg Pro Asp Phe Glu Ser Glu Lys Ala Lys 
    370                 375                 380                 


Val Ser Leu Gln Cys Asn Ser Thr Lys Asn Leu Thr Phe Ala Met Arg 
385                 390                 395                 400 


Ser Ser Gly Asp Tyr Gly Glu Val Thr Gly Ala Trp Ile Glu Phe Gly 
                405                 410                 415     


Cys His Arg Asn Lys Ser Lys Leu His Thr Glu Ala Arg Phe Arg Ile 
            420                 425                 430         


Arg Cys Arg Trp Asn Val Gly Asp Asn Thr Ser Leu Ile Asp Thr Cys 
        435                 440                 445             


Gly Glu Thr Gln Asn Val Ser Gly Ala Asn Pro Val Asp Cys Thr Met 
    450                 455                 460                 


Tyr Ala Asn Arg Met Tyr Asn Cys Ser Leu Gln Asn Gly Phe Thr Met 
465                 470                 475                 480 


Lys Val Asp Asp Leu Ile Met His Phe Asn Met Thr Lys Ala Val Glu 
                485                 490                 495     


Met Tyr Asp Ile Ala Gly Asn Trp Ser Cys Thr Ser Asp Leu Pro Pro 
            500                 505                 510         


Thr Trp Gly Tyr Met Asn Cys Asn Cys Thr Asn Ser Ser Ser Thr Asn 
        515                 520                 525             


Ser Val Lys Met Ala Cys Pro Lys Asn Gln Gly Ile Leu Arg Asn Trp 
    530                 535                 540                 


Tyr Asn Pro Val Ala Gly Leu Arg Gln Ser Leu Glu Lys Tyr Gln Val 
545                 550                 555                 560 


Val Lys Gln Pro Asp Tyr Leu Val Val Pro Gly Glu Val Met Glu Tyr 
                565                 570                 575     


Lys Pro Arg Arg Lys Arg Ala Ala Ile His Val Met Leu Ala Leu Ala 
            580                 585                 590         


Thr Val Leu Ser Met Ala Gly Ala Gly Thr Gly Ala Thr Ala Ile Gly 
        595                 600                 605             


Met Val Thr Gln Tyr His Gln Val Leu Ala Thr His Gln Glu Thr Ile 
    610                 615                 620                 


Glu Lys Val Thr Glu Ala Leu Lys Ile Asn Asn Leu Arg Leu Val Thr 
625                 630                 635                 640 


Leu Glu His Gln Val Leu Val Ile Gly Leu Lys Val Glu Ala Met Glu 
                645                 650                 655     


Lys Phe Arg Tyr Thr Ala Phe Ala Met Gln Glu Leu Gly Cys Asn Gln 
            660                 665                 670         


Asn Gln Phe Phe Cys Lys Val Pro Pro Glu Leu Trp Lys Arg Tyr Asn 
        675                 680                 685             


Met Thr Ile Asn Gln Thr Ile Trp Asn His Gly Asn Ile Thr Leu Gly 
    690                 695                 700                 


Glu Trp Tyr Asn Gln Thr Lys Glu Leu Gln Gln Lys Phe Tyr Glu Ile 
705                 710                 715                 720 


Ile Met Asn Ile Glu Gln Asn Asn Val Gln Val Lys Lys Gly Leu Gln 
                725                 730                 735     


Gln Leu Gln Glu Trp Glu Asp Trp Val Gly Trp Ile Gly Asn Ile Pro 
            740                 745                 750         


Gln Tyr Leu Lys Gly Leu Leu Gly Gly Ile Leu Gly Ile Gly Ile Gly 
        755                 760                 765             


Val Leu Leu Leu Ile Leu Cys Leu Pro Thr Leu Val Asp Cys Ile Arg 
    770                 775                 780                 


Asn Cys Ile Ser Lys Val Leu Gly Tyr Thr Val Ile Ala Met Pro Glu 
785                 790                 795                 800 


Ile Gly Asp Glu Glu Glu Thr Val Gln Met Glu Leu Arg Lys Asn Gly 
                805                 810                 815     


Arg Gln Cys Gly Met Ser Glu Lys Glu Glu Glu 
            820                 825         


<210>  390
<211>  857
<212>  PRT
<213>  Artificial sequence

<220>
<223>  Mutated sequence

<400>  390

Met Ala Glu Gly Phe Ala Ala Asn Arg Gln Trp Ile Gly Pro Glu Glu 
1               5                   10                  15      


Ala Glu Glu Leu Leu Asp Phe Asp Ile Ala Thr Gln Met Asn Glu Glu 
            20                  25                  30          


Gly Pro Leu Asn Pro Gly Ile Asn Pro Phe Arg Val Pro Gly Ile Thr 
        35                  40                  45              


Glu Ile Glu Lys Arg Asp Tyr Cys Lys Ile Leu Gln Pro Lys Leu Gln 
    50                  55                  60                  


Asp Leu Lys Asn Glu Ile Gln Glu Val Lys Leu Glu Glu Gly Asn Ala 
65                  70                  75                  80  


Gly Lys Phe Arg Arg Ala Arg Phe Leu Arg Tyr Ser Asp Glu Asn Ile 
                85                  90                  95      


Leu Ser Leu Ile His Leu Phe Ile Gly Tyr Cys Thr Tyr Leu Cys Arg 
            100                 105                 110         


Lys Asn Glu Leu Gly Ser Leu Arg His Asp Ile Asp Ile Asp Glu His 
        115                 120                 125             


Gln Glu Glu Tyr Tyr Thr Asn Ile Glu Lys Gly Thr Thr Ala Asn Ile 
    130                 135                 140                 


Lys Tyr Gly Arg Arg Cys Leu Ile Gly Thr Ala Ala Leu Tyr Leu Leu 
145                 150                 155                 160 


Phe Ile Gly Ile Ile Ile Tyr Thr Gln Thr Thr Lys Ala Gln Val Val 
                165                 170                 175     


Trp Arg Leu Pro Pro Phe Val Val Pro Val Glu Glu Ser Glu Ile Ile 
            180                 185                 190         


Phe Trp Asp Cys Trp Ala Pro Glu Glu Pro Ala Cys Gln Asp Phe Leu 
        195                 200                 205             


Gly Ala Met Ile His Leu Lys Ala Ser Thr Asn Ile Ser Ile Gln Glu 
    210                 215                 220                 


Gly Pro Thr Leu Gly Asn Trp Ala Arg Glu Ile Trp Gly Thr Leu Phe 
225                 230                 235                 240 


Lys Lys Ala Thr Arg Gln Cys Arg Arg Gly Arg Val Trp Arg Arg Trp 
                245                 250                 255     


Asn Glu Thr Ile Thr Gly Pro Ser Gly Cys Ala Asn Asn Thr Cys Tyr 
            260                 265                 270         


Asn Ile Ser Val Ile Val Pro Asp Tyr Gln Cys Tyr Leu Asp Arg Val 
        275                 280                 285             


Asp Thr Trp Leu Gln Gly Lys Val Asn Ile Ser Leu Cys Leu Thr Gly 
    290                 295                 300                 


Gly Lys Met Leu Tyr Asn Lys Tyr Thr Lys Gln Leu Ser Tyr Cys Thr 
305                 310                 315                 320 


Asp Pro Leu Gln Ile Pro Leu Ile Asn Tyr Thr Phe Gly Pro Asn Gln 
                325                 330                 335     


Thr Cys Met Trp Asn Thr Ser Gln Ile Gln Asp Pro Glu Ile Pro Lys 
            340                 345                 350         


Cys Gly Trp Trp Asn Gln Ala Ala Tyr Tyr Asn Ser Cys Arg Trp Glu 
        355                 360                 365             


Ser Thr Asp Val Lys Phe His Cys Gln Arg Thr Gln Ser Leu Pro Gly 
    370                 375                 380                 


Thr Trp Leu Arg Thr Ile Ser Ser Trp Arg Pro Lys Asn Arg Trp Glu 
385                 390                 395                 400 


Trp Arg Pro Asp Phe Glu Ser Glu Lys Val Lys Val Ser Leu Gln Cys 
                405                 410                 415     


Asn Ser Thr Asn Asn Leu Thr Phe Ala Met Arg Ser Ser Gly Asp Tyr 
            420                 425                 430         


Gly Glu Val Thr Gly Ala Trp Ile Glu Phe Gly Cys His Arg Lys Lys 
        435                 440                 445             


Ser Lys Leu His Ser Glu Ala Arg Phe Arg Ile Arg Cys Arg Trp Asp 
    450                 455                 460                 


Lys Gly Asp Asn Thr Ser Leu Ile Asp Thr Cys Gly Lys Thr Gln Asn 
465                 470                 475                 480 


Val Leu Gly Ala Asn Pro Val Asp Cys Thr Met Tyr Ala Asn Arg Met 
                485                 490                 495     


Tyr Asn Cys Ser Leu Gln Asn Gly Phe Thr Met Lys Ile Asp Asp Leu 
            500                 505                 510         


Val Met His Phe Asn Met Thr Lys Ala Val Glu Met Tyr Asn Ile Ala 
        515                 520                 525             


Gly Asn Trp Ser Cys Thr Ser Asp Leu Pro Pro Thr Trp Gly Tyr Met 
    530                 535                 540                 


Asn Cys Asn Cys Thr Asn Ser Ser Ser Thr Ser Ser Ser Ser Gly Asn 
545                 550                 555                 560 


Lys Met Ala Cys Pro Gly Asp Lys Gly Ile Leu Arg Asn Trp Tyr Asn 
                565                 570                 575     


Pro Val Ala Gly Leu Arg Gln Ser Leu Glu Lys Tyr Gln Val Val Lys 
            580                 585                 590         


Gln Pro Asp Tyr Leu Val Val Pro Gly Glu Val Met Glu Tyr Lys Pro 
        595                 600                 605             


Arg Arg Lys Arg Ala Ala Ile His Val Met Leu Ala Leu Ala Thr Val 
    610                 615                 620                 


Leu Ser Met Ala Gly Ala Gly Thr Gly Ala Thr Ala Ile Gly Met Val 
625                 630                 635                 640 


Thr Gln Tyr His Gln Val Leu Ala Thr His Gln Glu Ala Ile Glu Lys 
                645                 650                 655     


Val Thr Glu Ala Leu Lys Ile Asn Asn Leu Arg Leu Val Thr Leu Glu 
            660                 665                 670         


His Gln Val Leu Val Ile Gly Leu Lys Val Glu Ala Met Glu Lys Arg 
        675                 680                 685             


Leu Tyr Thr Ala Phe Ala Met Gln Glu Leu Gly Cys Asn Gln Asn Gln 
    690                 695                 700                 


Phe Phe Cys Lys Val Pro Pro Val Leu Trp Glu Arg Tyr Asn Met Thr 
705                 710                 715                 720 


Ile Asn Gln Thr Ile Trp Asn His Gly Asn Ile Thr Leu Gly Glu Trp 
                725                 730                 735     


Tyr Asn Gln Thr Lys Asp Leu Gln Gln Lys Phe Tyr Glu Ile Ile Met 
            740                 745                 750         


Asp Ile Glu Gln Asn Asn Val Gln Gly Lys Lys Gly Leu Gln Gln Leu 
        755                 760                 765             


Gln Lys Trp Glu Asp Trp Val Gly Trp Ile Gly Asn Ile Pro Lys Tyr 
    770                 775                 780                 


Leu Lys Gly Leu Leu Gly Gly Ile Leu Gly Ile Gly Leu Gly Val Ile 
785                 790                 795                 800 


Leu Leu Ile Leu Cys Leu Pro Thr Leu Val Asp Cys Val Arg Asn Cys 
                805                 810                 815     


Ile His Lys Ile Leu Gly Tyr Thr Val Ile Ala Met Pro Glu Val Glu 
            820                 825                 830         


Glu Glu Glu Ile Gln Pro Gln Met Glu Leu Arg Arg Asn Gly Arg Gln 
        835                 840                 845             


Cys Gly Ile Ser Glu Lys Glu Glu Glu 
    850                 855         


<210>  391
<211>  857
<212>  PRT
<213>  Artificial sequence

<220>
<223>  Mutated sequence

<400>  391

Met Ala Glu Gly Phe Ala Ala Asn Arg Gln Trp Ile Gly Pro Glu Glu 
1               5                   10                  15      


Ala Glu Glu Leu Leu Asp Phe Asp Ile Ala Thr Gln Met Asn Glu Glu 
            20                  25                  30          


Gly Pro Leu Asn Pro Gly Ile Asn Pro Phe Arg Val Pro Gly Ile Thr 
        35                  40                  45              


Glu Ile Glu Lys Arg Asp Tyr Cys Lys Ile Leu Gln Pro Lys Leu Gln 
    50                  55                  60                  


Asp Leu Lys Asn Glu Ile Gln Glu Val Lys Leu Glu Glu Gly Asn Ala 
65                  70                  75                  80  


Gly Lys Phe Arg Arg Ala Arg Phe Leu Arg Tyr Ser Asp Glu Asn Ile 
                85                  90                  95      


Leu Ser Leu Ile His Leu Phe Ile Gly Tyr Cys Thr Tyr Leu Cys Arg 
            100                 105                 110         


Lys Asn Glu Leu Gly Ser Leu Arg His Asp Ile Asp Ile Asp Glu His 
        115                 120                 125             


Gln Glu Glu Tyr Tyr Thr Asn Ile Glu Lys Gly Thr Thr Ala Asn Ile 
    130                 135                 140                 


Lys Tyr Gly Arg Arg Cys Leu Ile Gly Thr Ala Ala Leu Tyr Leu Leu 
145                 150                 155                 160 


Phe Ile Gly Ile Ile Ile Tyr Thr Gln Thr Thr Lys Ala Gln Val Val 
                165                 170                 175     


Trp Arg Leu Pro Pro Phe Val Val Pro Val Glu Glu Ser Glu Ile Ile 
            180                 185                 190         


Phe Trp Asp Cys Trp Ala Pro Glu Glu Pro Ala Cys Gln Asp Phe Leu 
        195                 200                 205             


Gly Ala Met Ile His Leu Lys Ala Ser Thr Asn Ile Ser Ile Gln Glu 
    210                 215                 220                 


Gly Pro Thr Leu Gly Asn Trp Ala Arg Glu Ile Trp Gly Thr Leu Phe 
225                 230                 235                 240 


Lys Lys Ala Thr Arg Gln Cys Arg Arg Gly Arg Val Trp Arg Arg Trp 
                245                 250                 255     


Asn Glu Thr Ile Thr Gly Pro Ser Gly Cys Ala Asn Asn Thr Cys Tyr 
            260                 265                 270         


Asn Ile Ser Val Ile Val Pro Asp Tyr Gln Cys Tyr Leu Asp Arg Val 
        275                 280                 285             


Asp Thr Trp Leu Gln Gly Lys Val Asn Ile Ser Leu Cys Leu Thr Gly 
    290                 295                 300                 


Gly Lys Met Leu Tyr Asn Lys Tyr Thr Lys Gln Leu Ser Tyr Cys Thr 
305                 310                 315                 320 


Asp Pro Leu Gln Ile Pro Leu Ile Asn Tyr Thr Phe Gly Pro Asn Gln 
                325                 330                 335     


Thr Cys Met Trp Asn Thr Ser Gln Ile Gln Asp Pro Glu Ile Pro Lys 
            340                 345                 350         


Cys Gly Trp Trp Asn Gln Ala Ala Tyr Tyr Asn Ser Cys Arg Trp Glu 
        355                 360                 365             


Ser Thr Asp Val Lys Phe His Cys Gln Arg Thr Gln Ser Leu Pro Gly 
    370                 375                 380                 


Thr Trp Leu Arg Thr Ile Ser Ser Trp Arg Pro Lys Asn Arg Trp Glu 
385                 390                 395                 400 


Trp Arg Pro Asp Phe Glu Ser Glu Lys Val Lys Val Ser Leu Gln Cys 
                405                 410                 415     


Asn Ser Thr Asn Asn Leu Thr Phe Ala Met Arg Ser Ser Gly Asp Tyr 
            420                 425                 430         


Gly Glu Val Thr Gly Ala Trp Ile Glu Phe Gly Cys His Arg Lys Lys 
        435                 440                 445             


Ser Lys Leu His Ser Glu Ala Arg Phe Arg Ile Arg Cys Arg Trp Asp 
    450                 455                 460                 


Lys Gly Asp Asn Thr Ser Leu Ile Asp Thr Cys Gly Lys Thr Gln Asn 
465                 470                 475                 480 


Val Leu Gly Ala Asn Pro Val Asp Cys Thr Met Tyr Ala Asn Arg Met 
                485                 490                 495     


Tyr Asn Cys Ser Leu Gln Asn Gly Phe Thr Met Lys Ile Asp Asp Leu 
            500                 505                 510         


Val Met His Phe Asn Met Thr Lys Ala Val Glu Met Tyr Asn Ile Ala 
        515                 520                 525             


Gly Asn Trp Ser Cys Thr Ser Asp Leu Pro Pro Thr Trp Gly Tyr Met 
    530                 535                 540                 


Asn Cys Asn Cys Thr Asn Ser Ser Ser Thr Ser Ser Ser Ser Gly Asn 
545                 550                 555                 560 


Lys Met Ala Cys Pro Gly Asp Lys Gly Ile Leu Arg Asn Trp Tyr Asn 
                565                 570                 575     


Pro Val Ala Gly Leu Arg Gln Ser Leu Glu Lys Tyr Gln Val Val Lys 
            580                 585                 590         


Gln Pro Asp Tyr Leu Val Val Pro Gly Glu Val Met Glu Tyr Lys Pro 
        595                 600                 605             


Arg Arg Lys Arg Ala Ala Ile His Val Met Leu Ala Leu Ala Thr Val 
    610                 615                 620                 


Leu Ser Met Ala Gly Ala Gly Thr Gly Ala Thr Ala Ile Gly Met Val 
625                 630                 635                 640 


Thr Gln Tyr His Gln Val Leu Ala Thr His Gln Glu Ala Ile Glu Lys 
                645                 650                 655     


Val Thr Glu Ala Leu Lys Ile Asn Asn Leu Arg Leu Val Thr Leu Glu 
            660                 665                 670         


His Gln Val Leu Val Ile Gly Leu Lys Val Glu Ala Met Glu Lys Phe 
        675                 680                 685             


Arg Tyr Thr Ala Phe Ala Met Gln Glu Leu Gly Cys Asn Gln Asn Gln 
    690                 695                 700                 


Phe Phe Cys Lys Val Pro Pro Val Leu Trp Glu Arg Tyr Asn Met Thr 
705                 710                 715                 720 


Ile Asn Gln Thr Ile Trp Asn His Gly Asn Ile Thr Leu Gly Glu Trp 
                725                 730                 735     


Tyr Asn Gln Thr Lys Asp Leu Gln Gln Lys Phe Tyr Glu Ile Ile Met 
            740                 745                 750         


Asp Ile Glu Gln Asn Asn Val Gln Gly Lys Lys Gly Leu Gln Gln Leu 
        755                 760                 765             


Gln Lys Trp Glu Asp Trp Val Gly Trp Ile Gly Asn Ile Pro Lys Tyr 
    770                 775                 780                 


Leu Lys Gly Leu Leu Gly Gly Ile Leu Gly Ile Gly Leu Gly Val Ile 
785                 790                 795                 800 


Leu Leu Ile Leu Cys Leu Pro Thr Leu Val Asp Cys Val Arg Asn Cys 
                805                 810                 815     


Ile His Lys Ile Leu Gly Tyr Thr Val Ile Ala Met Pro Glu Val Glu 
            820                 825                 830         


Glu Glu Glu Ile Gln Pro Gln Met Glu Leu Arg Arg Asn Gly Arg Gln 
        835                 840                 845             


Cys Gly Ile Ser Glu Lys Glu Glu Glu 
    850                 855         


<210>  392
<211>  855
<212>  PRT
<213>  Artificial sequence

<220>
<223>  Mutated sequence

<400>  392

Met Ala Glu Gly Phe Ala Val Asn Arg Gln Trp Ile Gly Pro Glu Glu 
1               5                   10                  15      


Ala Glu Glu Leu Leu Asp Phe Asp Ile Ala Thr Gln Met Asn Glu Glu 
            20                  25                  30          


Gly Pro Leu Asn Pro Gly Ile Asn Leu Phe Arg Val Pro Gly Ile Thr 
        35                  40                  45              


Glu Thr Glu Lys Gln Glu Tyr Cys Asn Ile Leu Gln Pro Lys Leu Gln 
    50                  55                  60                  


Asp Leu Arg Asn Glu Ile Gln Glu Val Lys Leu Glu Glu Gly Asn Ala 
65                  70                  75                  80  


Gly Lys Phe Arg Arg Ala Arg Phe Leu Arg Tyr Ser Asp Glu Thr Ile 
                85                  90                  95      


Leu Ser Leu Ile His Leu Phe Ile Gly Tyr Cys Thr Tyr Leu Cys Lys 
            100                 105                 110         


Arg Asn Lys Leu Gly Thr Leu Val His Asn Ile Asp Ile Glu Ala Pro 
        115                 120                 125             


Gln Glu Glu Cys Tyr Ser Asn Arg Glu Arg Gly Thr Thr Val Asn Ile 
    130                 135                 140                 


Lys Tyr Ser Arg Arg Cys Cys Ile Gly Thr Thr Ala Leu Tyr Leu Leu 
145                 150                 155                 160 


Leu Leu Thr Gly Ile Ile Ile Tyr Thr Gln Thr Thr Gln Ala Gln Val 
                165                 170                 175     


Val Trp Arg Leu Pro Pro Leu Val Val Pro Val Glu Glu Ser Glu Ile 
            180                 185                 190         


Ile Phe Trp Asp Cys Trp Ala Pro Glu Glu Pro Ala Cys Gln Asp Phe 
        195                 200                 205             


Leu Gly Ala Met Ile Tyr Leu Lys Ala Ser Thr Asn Ile Ser Ile Gln 
    210                 215                 220                 


Glu Gly Pro Thr Leu Gly Asn Trp Ala Arg Glu Ile Trp Gly Thr Leu 
225                 230                 235                 240 


Phe Lys Lys Ala Thr Arg Gln Cys Arg Arg Gly Arg Ile Trp Arg Arg 
                245                 250                 255     


Trp Asn Glu Thr Ile Thr Gly Pro Ser Gly Cys Ala Asn Asn Thr Cys 
            260                 265                 270         


Tyr Asn Ile Ser Val Ile Val Pro Asp Tyr Gln Cys Tyr Leu Asp Arg 
        275                 280                 285             


Val Asp Thr Trp Leu Gln Gly Lys Val Asn Ile Ser Leu Cys Leu Thr 
    290                 295                 300                 


Gly Gly Lys Met Leu Tyr Asn Lys Asp Thr Lys Gln Leu Ser Tyr Cys 
305                 310                 315                 320 


Thr Asp Pro Leu Gln Ile Pro Leu Ile Asn Tyr Thr Phe Gly Pro Asn 
                325                 330                 335     


Gln Thr Cys Met Trp Asn Thr Ser Gln Ile Gln Asp Ser Asp Ile Pro 
            340                 345                 350         


Lys Cys Gly Trp Trp Asn Gln Ile Ala Tyr Tyr Asn Ser Cys Arg Trp 
        355                 360                 365             


Glu Gln Thr Asp Val Lys Phe His Cys Gln Arg Thr Gln Ser Gln Pro 
    370                 375                 380                 


Gly Thr Trp Leu Arg Thr Ile Ser Ser Trp Lys Gln Lys Asn Arg Trp 
385                 390                 395                 400 


Glu Trp Arg Pro Asp Phe Glu Ser Glu Lys Val Arg Val Ser Leu Gln 
                405                 410                 415     


Cys Asn Thr Thr Lys Asn Leu Thr Phe Ala Met Arg Ser Ser Gly Asp 
            420                 425                 430         


Tyr Gly Glu Val Thr Gly Ala Trp Ile Glu Phe Gly Cys His Arg Asn 
        435                 440                 445             


Lys Ser Lys Leu His Ser Asp Ala Arg Phe Arg Ile Arg Cys Arg Trp 
    450                 455                 460                 


Asn Val Gly Asp Asn Thr Ser Leu Ile Asp Thr Cys Gly Asn Asp Pro 
465                 470                 475                 480 


Asn Val Ser Gly Ala Asn Pro Val Asp Cys Thr Met Tyr Ala Asn Arg 
                485                 490                 495     


Met Tyr Asn Cys Ser Leu Gln Asn Gly Phe Thr Met Lys Val Asp Asp 
            500                 505                 510         


Leu Ile Met His Phe Asn Met Thr Lys Ala Val Glu Met Tyr Asn Ile 
        515                 520                 525             


Ala Gly Asn Trp Ser Cys Thr Ser Asp Leu Pro Ser Thr Trp Gly Tyr 
    530                 535                 540                 


Met Asn Cys Asn Cys Thr Asn Ser Ser Ser Thr Asp Ser Asn Lys Met 
545                 550                 555                 560 


Ala Cys Pro Lys Arg Gln Gly Ile Leu Arg Asn Trp Tyr Asn Pro Val 
                565                 570                 575     


Ala Gly Leu Arg Gln Ser Leu Glu Lys Tyr Gln Val Val Lys Gln Pro 
            580                 585                 590         


Asp Tyr Leu Val Val Pro Arg Glu Val Met Glu Tyr Lys Pro Arg Arg 
        595                 600                 605             


Lys Arg Ala Ala Ile His Val Met Leu Ala Leu Ala Thr Val Leu Ser 
    610                 615                 620                 


Met Ala Gly Ala Gly Thr Gly Ala Thr Ala Ile Gly Met Val Thr Gln 
625                 630                 635                 640 


Tyr His Gln Val Leu Ala Thr His Gln Glu Thr Ile Glu Lys Ile Thr 
                645                 650                 655     


Glu Ala Leu Lys Val Asn Asn Leu Arg Leu Val Thr Leu Glu His Gln 
            660                 665                 670         


Val Leu Val Ile Gly Leu Lys Val Glu Ala Ile Glu Lys Arg Leu Tyr 
        675                 680                 685             


Thr Ala Phe Ala Met Gln Glu Leu Gly Cys Asn Gln Asn Gln Phe Phe 
    690                 695                 700                 


Cys Lys Val Pro Pro Glu Leu Trp Gln Arg Tyr Asn Met Thr Ile Asn 
705                 710                 715                 720 


Gln Thr Ile Trp Asn His Gly Asn Ile Thr Leu Gly Glu Trp Tyr Asn 
                725                 730                 735     


Gln Thr Lys Asp Leu Gln Gln Lys Phe Tyr Glu Ile Ile Met Asp Met 
            740                 745                 750         


Glu Gln Asn Asn Val Gln Gly Arg Lys Gly Leu Gln Gln Leu Gln Glu 
        755                 760                 765             


Trp Glu Asp Trp Val Gly Trp Leu Gly Asn Ile Pro Arg Tyr Leu Lys 
    770                 775                 780                 


Gly Leu Leu Gly Gly Ile Leu Gly Ile Gly Leu Gly Val Leu Leu Leu 
785                 790                 795                 800 


Ile Leu Cys Leu Pro Thr Leu Val Asp Cys Ile Arg Asn Cys Ile Ser 
                805                 810                 815     


Lys Val Leu Gly Tyr Thr Val Ile Ala Met Pro Glu Val Glu Glu Glu 
            820                 825                 830         


Glu Ile Gln Pro Pro Met Glu Leu Arg Arg Asn Gly Arg Gln Cys Asp 
        835                 840                 845             


Met Ser Glu Lys Glu Glu Glu 
    850                 855 


<210>  393
<211>  855
<212>  PRT
<213>  Artificial sequence

<220>
<223>  Mutated sequence

<400>  393

Met Ala Glu Gly Phe Ala Val Asn Arg Gln Trp Ile Gly Pro Glu Glu 
1               5                   10                  15      


Ala Glu Glu Leu Leu Asp Phe Asp Ile Ala Thr Gln Met Asn Glu Glu 
            20                  25                  30          


Gly Pro Leu Asn Pro Gly Ile Asn Leu Phe Arg Val Pro Gly Ile Thr 
        35                  40                  45              


Glu Thr Glu Lys Gln Glu Tyr Cys Asn Ile Leu Gln Pro Lys Leu Gln 
    50                  55                  60                  


Asp Leu Arg Asn Glu Ile Gln Glu Val Lys Leu Glu Glu Gly Asn Ala 
65                  70                  75                  80  


Gly Lys Phe Arg Arg Ala Arg Phe Leu Arg Tyr Ser Asp Glu Thr Ile 
                85                  90                  95      


Leu Ser Leu Ile His Leu Phe Ile Gly Tyr Cys Thr Tyr Leu Cys Lys 
            100                 105                 110         


Arg Asn Lys Leu Gly Thr Leu Val His Asn Ile Asp Ile Glu Ala Pro 
        115                 120                 125             


Gln Glu Glu Cys Tyr Ser Asn Arg Glu Arg Gly Thr Thr Val Asn Ile 
    130                 135                 140                 


Lys Tyr Ser Arg Arg Cys Cys Ile Gly Thr Thr Ala Leu Tyr Leu Leu 
145                 150                 155                 160 


Leu Leu Thr Gly Ile Ile Ile Tyr Thr Gln Thr Thr Gln Ala Gln Val 
                165                 170                 175     


Val Trp Arg Leu Pro Pro Leu Val Val Pro Val Glu Glu Ser Glu Ile 
            180                 185                 190         


Ile Phe Trp Asp Cys Trp Ala Pro Glu Glu Pro Ala Cys Gln Asp Phe 
        195                 200                 205             


Leu Gly Ala Met Ile Tyr Leu Lys Ala Ser Thr Asn Ile Ser Ile Gln 
    210                 215                 220                 


Glu Gly Pro Thr Leu Gly Asn Trp Ala Arg Glu Ile Trp Gly Thr Leu 
225                 230                 235                 240 


Phe Lys Lys Ala Thr Arg Gln Cys Arg Arg Gly Arg Ile Trp Arg Arg 
                245                 250                 255     


Trp Asn Glu Thr Ile Thr Gly Pro Ser Gly Cys Ala Asn Asn Thr Cys 
            260                 265                 270         


Tyr Asn Ile Ser Val Ile Val Pro Asp Tyr Gln Cys Tyr Leu Asp Arg 
        275                 280                 285             


Val Asp Thr Trp Leu Gln Gly Lys Val Asn Ile Ser Leu Cys Leu Thr 
    290                 295                 300                 


Gly Gly Lys Met Leu Tyr Asn Lys Asp Thr Lys Gln Leu Ser Tyr Cys 
305                 310                 315                 320 


Thr Asp Pro Leu Gln Ile Pro Leu Ile Asn Tyr Thr Phe Gly Pro Asn 
                325                 330                 335     


Gln Thr Cys Met Trp Asn Thr Ser Gln Ile Gln Asp Ser Asp Ile Pro 
            340                 345                 350         


Lys Cys Gly Trp Trp Asn Gln Ile Ala Tyr Tyr Asn Ser Cys Arg Trp 
        355                 360                 365             


Glu Gln Thr Asp Val Lys Phe His Cys Gln Arg Thr Gln Ser Gln Pro 
    370                 375                 380                 


Gly Thr Trp Leu Arg Thr Ile Ser Ser Trp Lys Gln Lys Asn Arg Trp 
385                 390                 395                 400 


Glu Trp Arg Pro Asp Phe Glu Ser Glu Lys Val Arg Val Ser Leu Gln 
                405                 410                 415     


Cys Asn Thr Thr Lys Asn Leu Thr Phe Ala Met Arg Ser Ser Gly Asp 
            420                 425                 430         


Tyr Gly Glu Val Thr Gly Ala Trp Ile Glu Phe Gly Cys His Arg Asn 
        435                 440                 445             


Lys Ser Lys Leu His Ser Asp Ala Arg Phe Arg Ile Arg Cys Arg Trp 
    450                 455                 460                 


Asn Val Gly Asp Asn Thr Ser Leu Ile Asp Thr Cys Gly Asn Asp Pro 
465                 470                 475                 480 


Asn Val Ser Gly Ala Asn Pro Val Asp Cys Thr Met Tyr Ala Asn Arg 
                485                 490                 495     


Met Tyr Asn Cys Ser Leu Gln Asn Gly Phe Thr Met Lys Val Asp Asp 
            500                 505                 510         


Leu Ile Met His Phe Asn Met Thr Lys Ala Val Glu Met Tyr Asn Ile 
        515                 520                 525             


Ala Gly Asn Trp Ser Cys Thr Ser Asp Leu Pro Ser Thr Trp Gly Tyr 
    530                 535                 540                 


Met Asn Cys Asn Cys Thr Asn Ser Ser Ser Thr Asp Ser Asn Lys Met 
545                 550                 555                 560 


Ala Cys Pro Lys Arg Gln Gly Ile Leu Arg Asn Trp Tyr Asn Pro Val 
                565                 570                 575     


Ala Gly Leu Arg Gln Ser Leu Glu Lys Tyr Gln Val Val Lys Gln Pro 
            580                 585                 590         


Asp Tyr Leu Val Val Pro Arg Glu Val Met Glu Tyr Lys Pro Arg Arg 
        595                 600                 605             


Lys Arg Ala Ala Ile His Val Met Leu Ala Leu Ala Thr Val Leu Ser 
    610                 615                 620                 


Met Ala Gly Ala Gly Thr Gly Ala Thr Ala Ile Gly Met Val Thr Gln 
625                 630                 635                 640 


Tyr His Gln Val Leu Ala Thr His Gln Glu Thr Ile Glu Lys Ile Thr 
                645                 650                 655     


Glu Ala Leu Lys Val Asn Asn Leu Arg Leu Val Thr Leu Glu His Gln 
            660                 665                 670         


Val Leu Val Ile Gly Leu Lys Val Glu Ala Ile Glu Lys Phe Arg Tyr 
        675                 680                 685             


Thr Ala Phe Ala Met Gln Glu Leu Gly Cys Asn Gln Asn Gln Phe Phe 
    690                 695                 700                 


Cys Lys Val Pro Pro Glu Leu Trp Gln Arg Tyr Asn Met Thr Ile Asn 
705                 710                 715                 720 


Gln Thr Ile Trp Asn His Gly Asn Ile Thr Leu Gly Glu Trp Tyr Asn 
                725                 730                 735     


Gln Thr Lys Asp Leu Gln Gln Lys Phe Tyr Glu Ile Ile Met Asp Met 
            740                 745                 750         


Glu Gln Asn Asn Val Gln Gly Arg Lys Gly Leu Gln Gln Leu Gln Glu 
        755                 760                 765             


Trp Glu Asp Trp Val Gly Trp Leu Gly Asn Ile Pro Arg Tyr Leu Lys 
    770                 775                 780                 


Gly Leu Leu Gly Gly Ile Leu Gly Ile Gly Leu Gly Val Leu Leu Leu 
785                 790                 795                 800 


Ile Leu Cys Leu Pro Thr Leu Val Asp Cys Ile Arg Asn Cys Ile Ser 
                805                 810                 815     


Lys Val Leu Gly Tyr Thr Val Ile Ala Met Pro Glu Val Glu Glu Glu 
            820                 825                 830         


Glu Ile Gln Pro Pro Met Glu Leu Arg Arg Asn Gly Arg Gln Cys Asp 
        835                 840                 845             


Met Ser Glu Lys Glu Glu Glu 
    850                 855 


<210>  394
<211>  857
<212>  PRT
<213>  Artificial sequence

<220>
<223>  Mutated sequence

<400>  394

Met Ala Ala Gly Phe Ser Gln Asn Arg Gln Trp Ile Gly Pro Glu Glu 
1               5                   10                  15      


Ala Glu Glu Leu Leu Asp Phe Asp Ile Ala Thr Gln Ile Asn Glu Glu 
            20                  25                  30          


Gly Pro Leu Asn Pro Gly Val Asn Pro Phe Arg Val Pro Gly Ile Thr 
        35                  40                  45              


Asp Thr Glu Lys Gln Asp Tyr Cys Lys Ile Leu Gln Pro Lys Leu Gln 
    50                  55                  60                  


Glu Leu Arg Glu Glu Ile Asn Glu Val Lys Leu Asp Glu Asp Asn Ala 
65                  70                  75                  80  


Gly Lys Phe Arg Arg Val Arg Tyr Leu Arg Tyr Ala Asp Glu Thr Val 
                85                  90                  95      


Leu Ser Leu Ile Tyr Ala Leu Val Gly Tyr Leu Arg Tyr Leu Gly Asn 
            100                 105                 110         


Arg Asn Lys Leu Gly Ser Leu Arg His Asp Ile Asp Ile Glu Val Ser 
        115                 120                 125             


Ala Lys Glu Gln Phe Asp Lys Lys Glu Lys Gly Thr Thr Ile Asn Gln 
    130                 135                 140                 


Lys Tyr Cys Thr Arg Cys Cys Val Gly Ile Ser Val Leu Tyr Leu Ile 
145                 150                 155                 160 


Leu Phe Ile Ile Ile Val Ala Val Thr Gly Ser Gln Ala Gln Val Val 
                165                 170                 175     


Trp Arg His Pro Pro Leu Val Val Pro Val Glu Glu Thr Glu Ile Ile 
            180                 185                 190         


Phe Trp Asp Cys Trp Ala Pro Glu Glu Pro Ala Cys Gln Asp Phe Leu 
        195                 200                 205             


Gly Thr Met Val Gln Leu Lys Ala Ser Ile Asn Ile Gly Ile Gln Glu 
    210                 215                 220                 


Gly Pro Thr Leu Gly His Trp Ala Arg Glu Ile Trp Ser Thr Leu Phe 
225                 230                 235                 240 


Lys Lys Ala Thr Arg Gln Cys Arg Arg Gly Arg Val Trp Arg Arg Trp 
                245                 250                 255     


Asn Glu Thr Ile Thr Gly Pro Leu Gly Cys Ala Asn Asn Thr Cys Tyr 
            260                 265                 270         


Asn Ile Ser Val Val Val Pro Asp Tyr Gln Cys Tyr Val Asp Arg Val 
        275                 280                 285             


Asp Thr Trp Leu Gln Gly Arg Ile Asn Ile Ser Leu Cys Leu Thr Gly 
    290                 295                 300                 


Gly Lys Met Leu Tyr Asn Lys Asp Thr Gln Gln Leu Ser Tyr Cys Thr 
305                 310                 315                 320 


Glu Pro Leu Gln Ile Pro Leu Ile Asn Tyr Thr Phe Gly Pro Asn Gln 
                325                 330                 335     


Thr Cys Met Trp Asn Thr Ser Leu Ile Glu Asp Ser Glu Ile Pro Lys 
            340                 345                 350         


Cys Gly Trp Trp Asn Gln Ala Ala Tyr Tyr Asn Ser Cys Lys Trp Glu 
        355                 360                 365             


Gln Thr Asp Val Lys Phe Gln Cys Leu Arg Thr Gln Ser Gln Pro Gly 
    370                 375                 380                 


Asn Trp Leu Arg Thr Ile Ser Ser Trp Lys Gln Ser Asn Arg Trp Ile 
385                 390                 395                 400 


Trp Arg Pro Asp Phe Glu Ser Asp Lys Val Lys Ile Ser Leu Gln Cys 
                405                 410                 415     


Asn Ser Thr Lys Asn Leu Thr Phe Ala Met Arg Ser Ser Gly Asp Tyr 
            420                 425                 430         


Gly Glu Ile Thr Gly Ala Trp Ile Glu Phe Gly Cys Tyr Arg Asn Lys 
        435                 440                 445             


Ser Lys Ser His Gly Glu Ala Arg Phe Arg Ile Arg Cys Arg Trp Asn 
    450                 455                 460                 


Glu Gly Thr Asn Thr Ser Leu Ile Asp Thr Cys Gly Ser Thr Pro Asn 
465                 470                 475                 480 


Val Lys Gly Ala Asn Pro Val Asp Cys Thr Met Lys Ala Asn Thr Met 
                485                 490                 495     


Tyr Asn Cys Ser Leu Gln Asn Gly Phe Thr Met Lys Ile Glu Asp Leu 
            500                 505                 510         


Ile Val His Phe Asn Met Thr Lys Ala Val Glu Met Tyr Asn Ile Ala 
        515                 520                 525             


Gly Asn Trp Ser Cys Asn Ser Asp Ile Pro Pro Gly Trp Gly Tyr Met 
    530                 535                 540                 


Asn Cys Asn Cys Thr Asn Ser Thr Ser Ser Ser Phe Pro Thr Cys Pro 
545                 550                 555                 560 


Lys Met Ala Cys Pro Arg Glu Arg Gly Ile Leu Arg Asn Trp Tyr Asn 
                565                 570                 575     


Pro Ile Ala Gly Leu Arg His Ala Leu Gln Lys Tyr Gln Val Val Lys 
            580                 585                 590         


Gln Pro Ala Tyr Leu Leu Val Pro Glu Glu Val Met Glu Tyr Lys Pro 
        595                 600                 605             


Ser Gln Lys Arg Ala Ala Ile His Ile Ile Leu Ala Leu Ala Thr Val 
    610                 615                 620                 


Leu Ser Ile Ala Gly Ala Gly Thr Gly Ala Thr Ala Ile Gly Met Val 
625                 630                 635                 640 


Thr Gln Tyr His Gln Val Leu Ala Thr His Gln Lys Ala Ile Asp Gln 
                645                 650                 655     


Ile Thr Glu Ala Leu Lys Ile Asn Asn Leu Arg Leu Val Thr Leu Glu 
            660                 665                 670         


His Gln Val Leu Val Ile Gly Leu Lys Val Glu Ala Ile Glu Lys Arg 
        675                 680                 685             


Ile Tyr Thr Ala Phe Ala Met Gln Glu Leu Gly Cys Asn Gln Asn Gln 
    690                 695                 700                 


Phe Phe Cys Lys Ile Pro Pro Glu Leu Trp Ile Arg Tyr Asn Met Ser 
705                 710                 715                 720 


Ile Asn Gln Thr Ile Trp Asn His Gly Asn Ile Ser Leu Arg Asp Trp 
                725                 730                 735     


Tyr Asn Asn Thr Gln Gln Leu Gln Lys Lys Phe Tyr Glu Ile Ile Tyr 
            740                 745                 750         


Asp Ile Glu Gln Asn Asn Val Gln Gly Lys Gln Gly Leu Gln Gln Leu 
        755                 760                 765             


Gln Lys Trp Glu Thr Trp Val Ser Trp Ile Gly Lys Ile Pro Gln Tyr 
    770                 775                 780                 


Leu Lys Gly Leu Phe Gly Ser Ile Leu Gly Ile Gly Leu Gly Ile Leu 
785                 790                 795                 800 


Leu Met Ile Leu Cys Leu Pro Thr Leu Val Asp Cys Met Arg Asn Cys 
                805                 810                 815     


Leu Asn Arg Val Leu Gly Tyr Thr Val Ile Ala Met Pro Thr Ile Asp 
            820                 825                 830         


Asp Glu Gly Thr Asp Phe Pro Val Glu Leu Arg Arg Asn Gly Gly Gln 
        835                 840                 845             


Cys Gly Met Ser Glu Lys Glu Glu Glu 
    850                 855         


<210>  395
<211>  857
<212>  PRT
<213>  Artificial sequence

<220>
<223>  Mutated sequence

<400>  395

Met Ala Ala Gly Phe Ser Gln Asn Arg Gln Trp Ile Gly Pro Glu Glu 
1               5                   10                  15      


Ala Glu Glu Leu Leu Asp Phe Asp Ile Ala Thr Gln Ile Asn Glu Glu 
            20                  25                  30          


Gly Pro Leu Asn Pro Gly Val Asn Pro Phe Arg Val Pro Gly Ile Thr 
        35                  40                  45              


Asp Thr Glu Lys Gln Asp Tyr Cys Lys Ile Leu Gln Pro Lys Leu Gln 
    50                  55                  60                  


Glu Leu Arg Glu Glu Ile Asn Glu Val Lys Leu Asp Glu Asp Asn Ala 
65                  70                  75                  80  


Gly Lys Phe Arg Arg Val Arg Tyr Leu Arg Tyr Ala Asp Glu Thr Val 
                85                  90                  95      


Leu Ser Leu Ile Tyr Ala Leu Val Gly Tyr Leu Arg Tyr Leu Gly Asn 
            100                 105                 110         


Arg Asn Lys Leu Gly Ser Leu Arg His Asp Ile Asp Ile Glu Val Ser 
        115                 120                 125             


Ala Lys Glu Gln Phe Asp Lys Lys Glu Lys Gly Thr Thr Ile Asn Gln 
    130                 135                 140                 


Lys Tyr Cys Thr Arg Cys Cys Val Gly Ile Ser Val Leu Tyr Leu Ile 
145                 150                 155                 160 


Leu Phe Ile Ile Ile Val Ala Val Thr Gly Ser Gln Ala Gln Val Val 
                165                 170                 175     


Trp Arg His Pro Pro Leu Val Val Pro Val Glu Glu Thr Glu Ile Ile 
            180                 185                 190         


Phe Trp Asp Cys Trp Ala Pro Glu Glu Pro Ala Cys Gln Asp Phe Leu 
        195                 200                 205             


Gly Thr Met Val Gln Leu Lys Ala Ser Ile Asn Ile Gly Ile Gln Glu 
    210                 215                 220                 


Gly Pro Thr Leu Gly His Trp Ala Arg Glu Ile Trp Ser Thr Leu Phe 
225                 230                 235                 240 


Lys Lys Ala Thr Arg Gln Cys Arg Arg Gly Arg Val Trp Arg Arg Trp 
                245                 250                 255     


Asn Glu Thr Ile Thr Gly Pro Leu Gly Cys Ala Asn Asn Thr Cys Tyr 
            260                 265                 270         


Asn Ile Ser Val Val Val Pro Asp Tyr Gln Cys Tyr Val Asp Arg Val 
        275                 280                 285             


Asp Thr Trp Leu Gln Gly Arg Ile Asn Ile Ser Leu Cys Leu Thr Gly 
    290                 295                 300                 


Gly Lys Met Leu Tyr Asn Lys Asp Thr Gln Gln Leu Ser Tyr Cys Thr 
305                 310                 315                 320 


Glu Pro Leu Gln Ile Pro Leu Ile Asn Tyr Thr Phe Gly Pro Asn Gln 
                325                 330                 335     


Thr Cys Met Trp Asn Thr Ser Leu Ile Glu Asp Ser Glu Ile Pro Lys 
            340                 345                 350         


Cys Gly Trp Trp Asn Gln Ala Ala Tyr Tyr Asn Ser Cys Lys Trp Glu 
        355                 360                 365             


Gln Thr Asp Val Lys Phe Gln Cys Leu Arg Thr Gln Ser Gln Pro Gly 
    370                 375                 380                 


Asn Trp Leu Arg Thr Ile Ser Ser Trp Lys Gln Ser Asn Arg Trp Ile 
385                 390                 395                 400 


Trp Arg Pro Asp Phe Glu Ser Asp Lys Val Lys Ile Ser Leu Gln Cys 
                405                 410                 415     


Asn Ser Thr Lys Asn Leu Thr Phe Ala Met Arg Ser Ser Gly Asp Tyr 
            420                 425                 430         


Gly Glu Ile Thr Gly Ala Trp Ile Glu Phe Gly Cys Tyr Arg Asn Lys 
        435                 440                 445             


Ser Lys Ser His Gly Glu Ala Arg Phe Arg Ile Arg Cys Arg Trp Asn 
    450                 455                 460                 


Glu Gly Thr Asn Thr Ser Leu Ile Asp Thr Cys Gly Ser Thr Pro Asn 
465                 470                 475                 480 


Val Lys Gly Ala Asn Pro Val Asp Cys Thr Met Lys Ala Asn Thr Met 
                485                 490                 495     


Tyr Asn Cys Ser Leu Gln Asn Gly Phe Thr Met Lys Ile Glu Asp Leu 
            500                 505                 510         


Ile Val His Phe Asn Met Thr Lys Ala Val Glu Met Tyr Asn Ile Ala 
        515                 520                 525             


Gly Asn Trp Ser Cys Asn Ser Asp Ile Pro Pro Gly Trp Gly Tyr Met 
    530                 535                 540                 


Asn Cys Asn Cys Thr Asn Ser Thr Ser Ser Ser Phe Pro Thr Cys Pro 
545                 550                 555                 560 


Lys Met Ala Cys Pro Arg Glu Arg Gly Ile Leu Arg Asn Trp Tyr Asn 
                565                 570                 575     


Pro Ile Ala Gly Leu Arg His Ala Leu Gln Lys Tyr Gln Val Val Lys 
            580                 585                 590         


Gln Pro Ala Tyr Leu Leu Val Pro Glu Glu Val Met Glu Tyr Lys Pro 
        595                 600                 605             


Ser Gln Lys Arg Ala Ala Ile His Ile Ile Leu Ala Leu Ala Thr Val 
    610                 615                 620                 


Leu Ser Ile Ala Gly Ala Gly Thr Gly Ala Thr Ala Ile Gly Met Val 
625                 630                 635                 640 


Thr Gln Tyr His Gln Val Leu Ala Thr His Gln Lys Ala Ile Asp Gln 
                645                 650                 655     


Ile Thr Glu Ala Leu Lys Ile Asn Asn Leu Arg Leu Val Thr Leu Glu 
            660                 665                 670         


His Gln Val Leu Val Ile Gly Leu Lys Val Glu Ala Ile Glu Lys Phe 
        675                 680                 685             


Arg Tyr Thr Ala Phe Ala Met Gln Glu Leu Gly Cys Asn Gln Asn Gln 
    690                 695                 700                 


Phe Phe Cys Lys Ile Pro Pro Glu Leu Trp Ile Arg Tyr Asn Met Ser 
705                 710                 715                 720 


Ile Asn Gln Thr Ile Trp Asn His Gly Asn Ile Ser Leu Arg Asp Trp 
                725                 730                 735     


Tyr Asn Asn Thr Gln Gln Leu Gln Lys Lys Phe Tyr Glu Ile Ile Tyr 
            740                 745                 750         


Asp Ile Glu Gln Asn Asn Val Gln Gly Lys Gln Gly Leu Gln Gln Leu 
        755                 760                 765             


Gln Lys Trp Glu Thr Trp Val Ser Trp Ile Gly Lys Ile Pro Gln Tyr 
    770                 775                 780                 


Leu Lys Gly Leu Phe Gly Ser Ile Leu Gly Ile Gly Leu Gly Ile Leu 
785                 790                 795                 800 


Leu Met Ile Leu Cys Leu Pro Thr Leu Val Asp Cys Met Arg Asn Cys 
                805                 810                 815     


Leu Asn Arg Val Leu Gly Tyr Thr Val Ile Ala Met Pro Thr Ile Asp 
            820                 825                 830         


Asp Glu Gly Thr Asp Phe Pro Val Glu Leu Arg Arg Asn Gly Gly Gln 
        835                 840                 845             


Cys Gly Met Ser Glu Lys Glu Glu Glu 
    850                 855         


<210>  396
<211>  852
<212>  PRT
<213>  Artificial sequence

<220>
<223>  Mutated sequence

<400>  396

Met Ala Ala Gly Phe Thr Gln Asn Arg Gln Trp Ile Gly Pro Glu Glu 
1               5                   10                  15      


Ala Glu Glu Leu Leu Asp Phe Asp Ile Val Thr Gln Ile Asn Glu Glu 
            20                  25                  30          


Gly Pro Leu Asn Pro Gly Val Asn Pro Phe Arg Val Pro Ala Ile Thr 
        35                  40                  45              


Asp Thr Glu Lys Gln Asp Tyr Cys Lys Ile Leu Gln Pro Lys Leu Gln 
    50                  55                  60                  


Glu Leu Arg Glu Glu Ile Lys Glu Thr Lys Leu Asp Glu Ser Asn Ala 
65                  70                  75                  80  


Gly Lys Phe Arg Arg Val Arg Tyr Leu Arg Tyr Ala Asp Glu Thr Ala 
                85                  90                  95      


Leu Ser Leu Ile Tyr Ala Leu Val Gly Tyr Leu Arg Tyr Leu Leu Glu 
            100                 105                 110         


Arg Arg Lys Leu Gly Ser Leu Arg His Asp Val Asp Ile Glu Val Ser 
        115                 120                 125             


Ala Lys Glu Gln Phe Asn Lys Lys Glu Lys Gly Thr Thr Val Asn Gln 
    130                 135                 140                 


Asn Tyr Cys Thr Lys Cys Cys Val Gly Ile Ser Val Leu Tyr Phe Ile 
145                 150                 155                 160 


Leu Phe Leu Ile Leu Val Ala Val Thr Arg Ser Gln Ala Gln Val Val 
                165                 170                 175     


Trp Arg Leu Pro Pro Leu Val Val Pro Val Glu Glu Thr Glu Ile Ile 
            180                 185                 190         


Phe Trp Asp Cys Trp Ala Pro Glu Glu Pro Ala Cys Gln Asp Phe Leu 
        195                 200                 205             


Gly Thr Met Val Gln Leu Lys Ala Ser Ile Asn Ile Ser Ile Gln Glu 
    210                 215                 220                 


Gly Pro Thr Leu Gly His Trp Ala Arg Glu Ile Leu Glu Thr Leu Phe 
225                 230                 235                 240 


Lys Lys Ala Thr Arg Gln Cys Arg Arg Gly Arg Val Trp Lys Arg Trp 
                245                 250                 255     


Asn Glu Thr Ile Thr Gly Pro Leu Gly Cys Ala Asn Asn Thr Cys Tyr 
            260                 265                 270         


Asn Ile Ser Val Val Val Pro Asp Tyr Gln Cys Tyr Val Asp Arg Val 
        275                 280                 285             


Asp Thr Trp Leu Gln Gly Arg Ile Asn Ile Ser Leu Cys Leu Thr Gly 
    290                 295                 300                 


Gly Lys Met Leu Tyr Asn Lys Asp Thr Gln Gln Leu Ser Tyr Cys Thr 
305                 310                 315                 320 


Glu Pro Leu Gln Ile Pro Leu Ile Asn Tyr Thr Phe Gly Pro Asn Gln 
                325                 330                 335     


Thr Cys Met Trp Asn Thr Ser Leu Ile Glu Asp Ser Glu Ile Pro Lys 
            340                 345                 350         


Cys Gly Trp Trp Asn Gln Ala Ala Tyr Tyr Asn Ser Cys Lys Trp Glu 
        355                 360                 365             


Gln Thr Asp Val Lys Phe Gln Cys Gln Arg Thr Gln Ser Gln Pro Gly 
    370                 375                 380                 


Thr Trp Leu Arg Ala Ile Ala Ser Trp Lys Gln Ala Asn Arg Trp Ile 
385                 390                 395                 400 


Trp Arg Pro Asp Phe Glu Ser Asp Lys Val Lys Ile Ser Leu Gln Cys 
                405                 410                 415     


Asn Ser Thr Lys Asn Leu Thr Phe Ala Met Arg Ser Ser Ser Asp Tyr 
            420                 425                 430         


Gly Glu Ile Thr Gly Ala Trp Ile Glu Phe Gly Cys Tyr Arg Asn Lys 
        435                 440                 445             


Ser Lys Phe His Asp Glu Ala Arg Phe Arg Ile Arg Cys Arg Trp Asn 
    450                 455                 460                 


Glu Gly Thr Asn Thr Ser Leu Ile Asp Thr Cys Gly Asp Asn Pro Asn 
465                 470                 475                 480 


Val Thr Gly Ala Asn Pro Val Asp Cys Thr Met Arg Ala Asn Ile Met 
                485                 490                 495     


Tyr Asn Cys Ser Leu Gln Asn Gly Phe Thr Met Lys Ile Glu Asp Leu 
            500                 505                 510         


Ile Val His Phe Asn Met Thr Lys Ala Val Glu Met Tyr Asn Ile Ala 
        515                 520                 525             


Gly Asn Trp Ser Cys Thr Ser Asp Leu Pro Lys Gly Trp Gly Tyr Met 
    530                 535                 540                 


Asn Cys Asn Cys Thr Asn Gly Thr Asp Asn Thr Lys Met Thr Cys Pro 
545                 550                 555                 560 


Glu Asn Gln Gly Ile Leu Arg Asn Trp Tyr Asn Pro Val Ala Gly Leu 
                565                 570                 575     


Arg Gln Ala Leu Met Lys Tyr Gln Val Val Lys Gln Pro Glu Tyr Leu 
            580                 585                 590         


Ile Val Pro Glu Glu Val Met Gln Tyr Lys Ser Lys Gln Lys Arg Ala 
        595                 600                 605             


Ala Ile His Ile Met Leu Ala Leu Ala Thr Val Leu Ser Met Ala Gly 
    610                 615                 620                 


Ala Gly Thr Gly Ala Thr Ala Ile Gly Met Val Thr Gln Tyr His Gln 
625                 630                 635                 640 


Val Leu Ala Thr His Gln Gln Ala Leu Asp Lys Ile Thr Glu Ala Leu 
                645                 650                 655     


Lys Ile Asn Asn Leu Arg Leu Ile Thr Leu Glu His Gln Val Leu Val 
            660                 665                 670         


Ile Gly Leu Lys Val Glu Ala Ile Glu Lys Arg Leu Tyr Thr Ala Phe 
        675                 680                 685             


Ala Met Gln Glu Leu Gly Cys Asn Gln Asn Gln Phe Phe Cys Lys Ile 
    690                 695                 700                 


Pro Pro Ser Leu Trp Ser Met Tyr Asn Met Thr Leu Asn Gln Thr Ile 
705                 710                 715                 720 


Trp Asn His Gly Asn Ile Ser Leu Gly Asn Trp Tyr Asn Gln Thr Arg 
                725                 730                 735     


Asp Leu Gln Asn Lys Phe Tyr Glu Ile Ile Met Asp Ile Glu Gln Asn 
            740                 745                 750         


Asn Val Gln Gly Lys Thr Gly Ile Gln Gln Leu Gln Lys Trp Glu Asn 
        755                 760                 765             


Trp Val Gly Trp Ile Gly Lys Ile Pro Gln Tyr Leu Lys Gly Leu Leu 
    770                 775                 780                 


Gly Ser Val Leu Gly Ile Gly Leu Gly Ile Leu Leu Leu Leu Ile Cys 
785                 790                 795                 800 


Leu Pro Thr Leu Val Asp Cys Ile Arg Asn Cys Thr Asn Lys Ile Leu 
                805                 810                 815     


Gly Tyr Thr Val Ile Ala Met Pro Glu Ile Asp Asp Glu Glu Val His 
            820                 825                 830         


Leu Ser Val Glu Leu Arg Arg Asn Gly Arg Gln Cys Gly Ile Ser Glu 
        835                 840                 845             


Lys Glu Glu Glu 
    850         


<210>  397
<211>  852
<212>  PRT
<213>  Artificial sequence

<220>
<223>  Mutated sequence

<400>  397

Met Ala Ala Gly Phe Thr Gln Asn Arg Gln Trp Ile Gly Pro Glu Glu 
1               5                   10                  15      


Ala Glu Glu Leu Leu Asp Phe Asp Ile Val Thr Gln Ile Asn Glu Glu 
            20                  25                  30          


Gly Pro Leu Asn Pro Gly Val Asn Pro Phe Arg Val Pro Ala Ile Thr 
        35                  40                  45              


Asp Thr Glu Lys Gln Asp Tyr Cys Lys Ile Leu Gln Pro Lys Leu Gln 
    50                  55                  60                  


Glu Leu Arg Glu Glu Ile Lys Glu Thr Lys Leu Asp Glu Ser Asn Ala 
65                  70                  75                  80  


Gly Lys Phe Arg Arg Val Arg Tyr Leu Arg Tyr Ala Asp Glu Thr Ala 
                85                  90                  95      


Leu Ser Leu Ile Tyr Ala Leu Val Gly Tyr Leu Arg Tyr Leu Leu Glu 
            100                 105                 110         


Arg Arg Lys Leu Gly Ser Leu Arg His Asp Val Asp Ile Glu Val Ser 
        115                 120                 125             


Ala Lys Glu Gln Phe Asn Lys Lys Glu Lys Gly Thr Thr Val Asn Gln 
    130                 135                 140                 


Asn Tyr Cys Thr Lys Cys Cys Val Gly Ile Ser Val Leu Tyr Phe Ile 
145                 150                 155                 160 


Leu Phe Leu Ile Leu Val Ala Val Thr Arg Ser Gln Ala Gln Val Val 
                165                 170                 175     


Trp Arg Leu Pro Pro Leu Val Val Pro Val Glu Glu Thr Glu Ile Ile 
            180                 185                 190         


Phe Trp Asp Cys Trp Ala Pro Glu Glu Pro Ala Cys Gln Asp Phe Leu 
        195                 200                 205             


Gly Thr Met Val Gln Leu Lys Ala Ser Ile Asn Ile Ser Ile Gln Glu 
    210                 215                 220                 


Gly Pro Thr Leu Gly His Trp Ala Arg Glu Ile Leu Glu Thr Leu Phe 
225                 230                 235                 240 


Lys Lys Ala Thr Arg Gln Cys Arg Arg Gly Arg Val Trp Lys Arg Trp 
                245                 250                 255     


Asn Glu Thr Ile Thr Gly Pro Leu Gly Cys Ala Asn Asn Thr Cys Tyr 
            260                 265                 270         


Asn Ile Ser Val Val Val Pro Asp Tyr Gln Cys Tyr Val Asp Arg Val 
        275                 280                 285             


Asp Thr Trp Leu Gln Gly Arg Ile Asn Ile Ser Leu Cys Leu Thr Gly 
    290                 295                 300                 


Gly Lys Met Leu Tyr Asn Lys Asp Thr Gln Gln Leu Ser Tyr Cys Thr 
305                 310                 315                 320 


Glu Pro Leu Gln Ile Pro Leu Ile Asn Tyr Thr Phe Gly Pro Asn Gln 
                325                 330                 335     


Thr Cys Met Trp Asn Thr Ser Leu Ile Glu Asp Ser Glu Ile Pro Lys 
            340                 345                 350         


Cys Gly Trp Trp Asn Gln Ala Ala Tyr Tyr Asn Ser Cys Lys Trp Glu 
        355                 360                 365             


Gln Thr Asp Val Lys Phe Gln Cys Gln Arg Thr Gln Ser Gln Pro Gly 
    370                 375                 380                 


Thr Trp Leu Arg Ala Ile Ala Ser Trp Lys Gln Ala Asn Arg Trp Ile 
385                 390                 395                 400 


Trp Arg Pro Asp Phe Glu Ser Asp Lys Val Lys Ile Ser Leu Gln Cys 
                405                 410                 415     


Asn Ser Thr Lys Asn Leu Thr Phe Ala Met Arg Ser Ser Ser Asp Tyr 
            420                 425                 430         


Gly Glu Ile Thr Gly Ala Trp Ile Glu Phe Gly Cys Tyr Arg Asn Lys 
        435                 440                 445             


Ser Lys Phe His Asp Glu Ala Arg Phe Arg Ile Arg Cys Arg Trp Asn 
    450                 455                 460                 


Glu Gly Thr Asn Thr Ser Leu Ile Asp Thr Cys Gly Asp Asn Pro Asn 
465                 470                 475                 480 


Val Thr Gly Ala Asn Pro Val Asp Cys Thr Met Arg Ala Asn Ile Met 
                485                 490                 495     


Tyr Asn Cys Ser Leu Gln Asn Gly Phe Thr Met Lys Ile Glu Asp Leu 
            500                 505                 510         


Ile Val His Phe Asn Met Thr Lys Ala Val Glu Met Tyr Asn Ile Ala 
        515                 520                 525             


Gly Asn Trp Ser Cys Thr Ser Asp Leu Pro Lys Gly Trp Gly Tyr Met 
    530                 535                 540                 


Asn Cys Asn Cys Thr Asn Gly Thr Asp Asn Thr Lys Met Thr Cys Pro 
545                 550                 555                 560 


Glu Asn Gln Gly Ile Leu Arg Asn Trp Tyr Asn Pro Val Ala Gly Leu 
                565                 570                 575     


Arg Gln Ala Leu Met Lys Tyr Gln Val Val Lys Gln Pro Glu Tyr Leu 
            580                 585                 590         


Ile Val Pro Glu Glu Val Met Gln Tyr Lys Ser Lys Gln Lys Arg Ala 
        595                 600                 605             


Ala Ile His Ile Met Leu Ala Leu Ala Thr Val Leu Ser Met Ala Gly 
    610                 615                 620                 


Ala Gly Thr Gly Ala Thr Ala Ile Gly Met Val Thr Gln Tyr His Gln 
625                 630                 635                 640 


Val Leu Ala Thr His Gln Gln Ala Leu Asp Lys Ile Thr Glu Ala Leu 
                645                 650                 655     


Lys Ile Asn Asn Leu Arg Leu Ile Thr Leu Glu His Gln Val Leu Val 
            660                 665                 670         


Ile Gly Leu Lys Val Glu Ala Ile Glu Lys Phe Arg Tyr Thr Ala Phe 
        675                 680                 685             


Ala Met Gln Glu Leu Gly Cys Asn Gln Asn Gln Phe Phe Cys Lys Ile 
    690                 695                 700                 


Pro Pro Ser Leu Trp Ser Met Tyr Asn Met Thr Leu Asn Gln Thr Ile 
705                 710                 715                 720 


Trp Asn His Gly Asn Ile Ser Leu Gly Asn Trp Tyr Asn Gln Thr Arg 
                725                 730                 735     


Asp Leu Gln Asn Lys Phe Tyr Glu Ile Ile Met Asp Ile Glu Gln Asn 
            740                 745                 750         


Asn Val Gln Gly Lys Thr Gly Ile Gln Gln Leu Gln Lys Trp Glu Asn 
        755                 760                 765             


Trp Val Gly Trp Ile Gly Lys Ile Pro Gln Tyr Leu Lys Gly Leu Leu 
    770                 775                 780                 


Gly Ser Val Leu Gly Ile Gly Leu Gly Ile Leu Leu Leu Leu Ile Cys 
785                 790                 795                 800 


Leu Pro Thr Leu Val Asp Cys Ile Arg Asn Cys Thr Asn Lys Ile Leu 
                805                 810                 815     


Gly Tyr Thr Val Ile Ala Met Pro Glu Ile Asp Asp Glu Glu Val His 
            820                 825                 830         


Leu Ser Val Glu Leu Arg Arg Asn Gly Arg Gln Cys Gly Ile Ser Glu 
        835                 840                 845             


Lys Glu Glu Glu 
    850         


<210>  398
<211>  853
<212>  PRT
<213>  Artificial sequence

<220>
<223>  Mutated sequence

<400>  398

Met Ala Glu Gly Phe Cys Gln Asn Arg Gln Trp Ile Gly Pro Glu Glu 
1               5                   10                  15      


Ala Glu Glu Leu Leu Asp Phe Asp Ile Ala Thr Gln Val Ser Glu Glu 
            20                  25                  30          


Gly Pro Leu Asn Pro Gly Ile Asn Pro Phe Arg Gln Pro Gly Leu Thr 
        35                  40                  45              


Asp Gly Glu Lys Glu Glu Tyr Cys Lys Ile Leu Gln Pro Arg Leu Gln 
    50                  55                  60                  


Ala Leu Arg Glu Glu Tyr Lys Glu Gly Ser Leu Asn Ser Glu Ser Ala 
65                  70                  75                  80  


Gly Lys Tyr Arg Arg Val Arg Tyr Leu Arg Tyr Ser Asp Leu Arg Val 
                85                  90                  95      


Leu Ser Leu Leu Tyr Leu Phe Ile Gly Tyr Leu Ala Phe Phe Val Arg 
            100                 105                 110         


Lys Arg Gly Leu Gly Lys Gln Arg Gln Asp Ile Asp Ile Glu Ser Lys 
        115                 120                 125             


Gly Thr Glu Glu Lys Phe Ser Lys Asn Glu Lys Gly Gln Thr Val Asn 
    130                 135                 140                 


Ile Arg Asn Cys Arg Ile Leu Thr Ile Ala Ile Cys Ser Phe Tyr Ile 
145                 150                 155                 160 


Phe Leu Phe Ile Gly Ile Gly Ile Tyr Ala Gly Lys Gly Glu Ala Gln 
                165                 170                 175     


Val Ile Trp Arg Leu Pro Pro Leu Val Val Pro Val Glu Asp Ser Glu 
            180                 185                 190         


Ile Ile Phe Trp Asp Cys Trp Ala Pro Glu Glu Pro Ala Cys Gln Asp 
        195                 200                 205             


Phe Leu Gly Ala Met Met His Leu Lys Ala Ser Thr Asn Ile Ser Ile 
    210                 215                 220                 


Gln Glu Gly Pro Thr Leu Gly Lys Trp Ala Lys Glu Ile Trp Ala Thr 
225                 230                 235                 240 


Leu Phe Lys Lys Ala Thr Arg Gln Cys Arg Arg Gly Lys Val Trp Arg 
                245                 250                 255     


Lys Trp Asn Glu Thr Ile Thr Gly Pro Lys Gly Cys Ala Asn Asn Thr 
            260                 265                 270         


Cys Tyr Asn Val Thr Val Ser Ile Pro Asp Tyr Gln Cys Tyr Leu Asp 
        275                 280                 285             


Arg Val Asp Thr Trp Leu Gln Gly Lys Val Asn Ile Ser Leu Cys Leu 
    290                 295                 300                 


Thr Gly Gly Lys Met Leu Tyr Asn Lys Glu Thr Lys Gln Leu Ser Tyr 
305                 310                 315                 320 


Cys Thr Asp Pro Leu Gln Ile Pro Leu Ile Asn Tyr Thr Phe Gly Pro 
                325                 330                 335     


Asn Gln Thr Cys Met Trp Asn Thr Ser Leu Ile Lys Asn Pro Asp Ile 
            340                 345                 350         


Pro Lys Cys Gly Trp Trp Asn Gln Ala Val Tyr Tyr Asn Ser Cys Arg 
        355                 360                 365             


Trp Glu Lys Ala Asp Val Gln Phe Gln Cys Gln Arg Thr Gln Ser Gln 
    370                 375                 380                 


Pro Gly Thr Trp Leu Arg Lys Ile Ser Ser Trp Lys Gln Lys Asn Arg 
385                 390                 395                 400 


Trp Glu Trp Arg Pro Asp Phe Glu Ser Glu Arg Val Lys Ile Ser Leu 
                405                 410                 415     


Gln Cys Asn Ser Thr Lys Asn Leu Thr Phe Ala Met Arg Ser Ser Ser 
            420                 425                 430         


Asp Tyr Ser Asp Val Val Gly Ala Trp Ile Glu Phe Gly Cys His Arg 
        435                 440                 445             


Asn Lys Ser Arg Arg His Thr Asp Ala Arg Phe Arg Ile Arg Cys Lys 
    450                 455                 460                 


Trp Asn Val Gly Ser Asn Thr Ser Leu Ile Asp Thr Cys Gly Lys Glu 
465                 470                 475                 480 


Asn Ile Thr Gly Ala Asn Pro Val Asp Cys Thr Met Thr Ala Lys Thr 
                485                 490                 495     


Leu Tyr Asn Cys Ser Leu Gln Glu Gly Phe Thr Met Lys Ile Glu Asp 
            500                 505                 510         


Leu Ile Met His Phe Asn Met Thr Lys Ala Val Glu Met Tyr Glu Ile 
        515                 520                 525             


Ala Gly Asn Trp Ser Cys Lys Ser Asp Leu Pro Thr Asp Trp Gly Tyr 
    530                 535                 540                 


Met Lys Cys Asn Cys Thr Ser Arg Asn Glu Ser Glu Lys Met Lys Cys 
545                 550                 555                 560 


Pro Ala Lys Asp Gly Ile Leu Arg Asn Trp Tyr Asn Pro Val Ala Gly 
                565                 570                 575     


Leu Arg Gln Ala Leu Asp Lys Tyr Gln Val Val Lys Gln Pro Asp Tyr 
            580                 585                 590         


Ile Val Val Pro Glu Glu Val Leu Asn Tyr Gln Ser Arg Gln Lys Arg 
        595                 600                 605             


Ala Ala Ile His Ile Met Leu Ala Leu Ala Thr Val Leu Ser Ile Ala 
    610                 615                 620                 


Gly Ala Gly Thr Gly Ala Thr Ala Ile Gly Met Val Thr Gln Tyr His 
625                 630                 635                 640 


Gln Val Leu Ala Thr His Gln Glu Ala Leu Asp Lys Ile Thr Glu Ala 
                645                 650                 655     


Leu Lys Ile Asn Asn Leu Arg Leu Val Thr Leu Glu His Gln Val Leu 
            660                 665                 670         


Val Ile Gly Leu Lys Val Glu Ala Thr Glu Lys Arg Leu Tyr Thr Ala 
        675                 680                 685             


Phe Ala Met Gln Glu Leu Gly Cys Asn Gln Asn Gln Phe Phe Cys Lys 
    690                 695                 700                 


Ile Pro Cys Glu Leu Trp Met Arg Tyr Asn Leu Thr Leu Asn Gln Thr 
705                 710                 715                 720 


Ile Trp Asn His Gly Asn Val Thr Leu Gln Asp Trp Tyr Asn Gln Thr 
                725                 730                 735     


Lys Gln Leu Gln Gln Lys Phe Tyr Glu Ile Ile Met Asp Ile Glu Gln 
            740                 745                 750         


Asn Asn Val Gln Gly Lys Lys Gly Ile Gln Gln Leu Gln Ser Trp Glu 
        755                 760                 765             


Tyr Trp Thr Gly Trp Met Gly Lys Ile Pro Gln Tyr Leu Lys Gly Leu 
    770                 775                 780                 


Leu Gly Gly Val Leu Gly Ile Gly Leu Gly Ile Leu Leu Leu Ile Leu 
785                 790                 795                 800 


Cys Leu Pro Thr Leu Leu Asp Cys Met Arg Asn Cys Ile Asn Lys Val 
                805                 810                 815     


Met Gly Tyr Thr Val Ile Val Met Pro Glu Ile Asp Asp Glu Glu Leu 
            820                 825                 830         


Ser Gln Asn Met Glu Leu Arg Arg Asn Gly Arg Gln Cys Gly Met Ser 
        835                 840                 845             


Glu Lys Glu Glu Glu 
    850             


<210>  399
<211>  853
<212>  PRT
<213>  Artificial sequence

<220>
<223>  Mutated sequence

<400>  399

Met Ala Glu Gly Phe Cys Gln Asn Arg Gln Trp Ile Gly Pro Glu Glu 
1               5                   10                  15      


Ala Glu Glu Leu Leu Asp Phe Asp Ile Ala Thr Gln Val Ser Glu Glu 
            20                  25                  30          


Gly Pro Leu Asn Pro Gly Ile Asn Pro Phe Arg Gln Pro Gly Leu Thr 
        35                  40                  45              


Asp Gly Glu Lys Glu Glu Tyr Cys Lys Ile Leu Gln Pro Arg Leu Gln 
    50                  55                  60                  


Ala Leu Arg Glu Glu Tyr Lys Glu Gly Ser Leu Asn Ser Glu Ser Ala 
65                  70                  75                  80  


Gly Lys Tyr Arg Arg Val Arg Tyr Leu Arg Tyr Ser Asp Leu Arg Val 
                85                  90                  95      


Leu Ser Leu Leu Tyr Leu Phe Ile Gly Tyr Leu Ala Phe Phe Val Arg 
            100                 105                 110         


Lys Arg Gly Leu Gly Lys Gln Arg Gln Asp Ile Asp Ile Glu Ser Lys 
        115                 120                 125             


Gly Thr Glu Glu Lys Phe Ser Lys Asn Glu Lys Gly Gln Thr Val Asn 
    130                 135                 140                 


Ile Arg Asn Cys Arg Ile Leu Thr Ile Ala Ile Cys Ser Phe Tyr Ile 
145                 150                 155                 160 


Phe Leu Phe Ile Gly Ile Gly Ile Tyr Ala Gly Lys Gly Glu Ala Gln 
                165                 170                 175     


Val Ile Trp Arg Leu Pro Pro Leu Val Val Pro Val Glu Asp Ser Glu 
            180                 185                 190         


Ile Ile Phe Trp Asp Cys Trp Ala Pro Glu Glu Pro Ala Cys Gln Asp 
        195                 200                 205             


Phe Leu Gly Ala Met Met His Leu Lys Ala Ser Thr Asn Ile Ser Ile 
    210                 215                 220                 


Gln Glu Gly Pro Thr Leu Gly Lys Trp Ala Lys Glu Ile Trp Ala Thr 
225                 230                 235                 240 


Leu Phe Lys Lys Ala Thr Arg Gln Cys Arg Arg Gly Lys Val Trp Arg 
                245                 250                 255     


Lys Trp Asn Glu Thr Ile Thr Gly Pro Lys Gly Cys Ala Asn Asn Thr 
            260                 265                 270         


Cys Tyr Asn Val Thr Val Ser Ile Pro Asp Tyr Gln Cys Tyr Leu Asp 
        275                 280                 285             


Arg Val Asp Thr Trp Leu Gln Gly Lys Val Asn Ile Ser Leu Cys Leu 
    290                 295                 300                 


Thr Gly Gly Lys Met Leu Tyr Asn Lys Glu Thr Lys Gln Leu Ser Tyr 
305                 310                 315                 320 


Cys Thr Asp Pro Leu Gln Ile Pro Leu Ile Asn Tyr Thr Phe Gly Pro 
                325                 330                 335     


Asn Gln Thr Cys Met Trp Asn Thr Ser Leu Ile Lys Asn Pro Asp Ile 
            340                 345                 350         


Pro Lys Cys Gly Trp Trp Asn Gln Ala Val Tyr Tyr Asn Ser Cys Arg 
        355                 360                 365             


Trp Glu Lys Ala Asp Val Gln Phe Gln Cys Gln Arg Thr Gln Ser Gln 
    370                 375                 380                 


Pro Gly Thr Trp Leu Arg Lys Ile Ser Ser Trp Lys Gln Lys Asn Arg 
385                 390                 395                 400 


Trp Glu Trp Arg Pro Asp Phe Glu Ser Glu Arg Val Lys Ile Ser Leu 
                405                 410                 415     


Gln Cys Asn Ser Thr Lys Asn Leu Thr Phe Ala Met Arg Ser Ser Ser 
            420                 425                 430         


Asp Tyr Ser Asp Val Val Gly Ala Trp Ile Glu Phe Gly Cys His Arg 
        435                 440                 445             


Asn Lys Ser Arg Arg His Thr Asp Ala Arg Phe Arg Ile Arg Cys Lys 
    450                 455                 460                 


Trp Asn Val Gly Ser Asn Thr Ser Leu Ile Asp Thr Cys Gly Lys Glu 
465                 470                 475                 480 


Asn Ile Thr Gly Ala Asn Pro Val Asp Cys Thr Met Thr Ala Lys Thr 
                485                 490                 495     


Leu Tyr Asn Cys Ser Leu Gln Glu Gly Phe Thr Met Lys Ile Glu Asp 
            500                 505                 510         


Leu Ile Met His Phe Asn Met Thr Lys Ala Val Glu Met Tyr Glu Ile 
        515                 520                 525             


Ala Gly Asn Trp Ser Cys Lys Ser Asp Leu Pro Thr Asp Trp Gly Tyr 
    530                 535                 540                 


Met Lys Cys Asn Cys Thr Ser Arg Asn Glu Ser Glu Lys Met Lys Cys 
545                 550                 555                 560 


Pro Ala Lys Asp Gly Ile Leu Arg Asn Trp Tyr Asn Pro Val Ala Gly 
                565                 570                 575     


Leu Arg Gln Ala Leu Asp Lys Tyr Gln Val Val Lys Gln Pro Asp Tyr 
            580                 585                 590         


Ile Val Val Pro Glu Glu Val Leu Asn Tyr Gln Ser Arg Gln Lys Arg 
        595                 600                 605             


Ala Ala Ile His Ile Met Leu Ala Leu Ala Thr Val Leu Ser Ile Ala 
    610                 615                 620                 


Gly Ala Gly Thr Gly Ala Thr Ala Ile Gly Met Val Thr Gln Tyr His 
625                 630                 635                 640 


Gln Val Leu Ala Thr His Gln Glu Ala Leu Asp Lys Ile Thr Glu Ala 
                645                 650                 655     


Leu Lys Ile Asn Asn Leu Arg Leu Val Thr Leu Glu His Gln Val Leu 
            660                 665                 670         


Val Ile Gly Leu Lys Val Glu Ala Thr Glu Lys Phe Arg Tyr Thr Ala 
        675                 680                 685             


Phe Ala Met Gln Glu Leu Gly Cys Asn Gln Asn Gln Phe Phe Cys Lys 
    690                 695                 700                 


Ile Pro Cys Glu Leu Trp Met Arg Tyr Asn Leu Thr Leu Asn Gln Thr 
705                 710                 715                 720 


Ile Trp Asn His Gly Asn Val Thr Leu Gln Asp Trp Tyr Asn Gln Thr 
                725                 730                 735     


Lys Gln Leu Gln Gln Lys Phe Tyr Glu Ile Ile Met Asp Ile Glu Gln 
            740                 745                 750         


Asn Asn Val Gln Gly Lys Lys Gly Ile Gln Gln Leu Gln Ser Trp Glu 
        755                 760                 765             


Tyr Trp Thr Gly Trp Met Gly Lys Ile Pro Gln Tyr Leu Lys Gly Leu 
    770                 775                 780                 


Leu Gly Gly Val Leu Gly Ile Gly Leu Gly Ile Leu Leu Leu Ile Leu 
785                 790                 795                 800 


Cys Leu Pro Thr Leu Leu Asp Cys Met Arg Asn Cys Ile Asn Lys Val 
                805                 810                 815     


Met Gly Tyr Thr Val Ile Val Met Pro Glu Ile Asp Asp Glu Glu Leu 
            820                 825                 830         


Ser Gln Asn Met Glu Leu Arg Arg Asn Gly Arg Gln Cys Gly Met Ser 
        835                 840                 845             


Glu Lys Glu Glu Glu 
    850             


<210>  400
<211>  851
<212>  PRT
<213>  Artificial sequence

<220>
<223>  Mutated sequence

<400>  400

Met Ala Glu Gly Gly Phe Ala Gln Asn Gln Gln Trp Ile Gly Pro Glu 
1               5                   10                  15      


Glu Ala Glu Glu Leu Leu Asp Phe Asp Ile Ala Val Gln Met Asn Glu 
            20                  25                  30          


Glu Gly Pro Leu Asn Pro Gly Val Asn Pro Phe Arg Val Pro Gly Ile 
        35                  40                  45              


Thr Pro Gln Glu Lys Asp Asn Tyr Cys Thr Ile Leu Gln Pro Arg Leu 
    50                  55                  60                  


Gln Glu Leu Lys Arg Glu Ile Lys Glu Val Lys Ile Glu Glu Glu Asn 
65                  70                  75                  80  


Ala Gly Lys Phe Arg Arg Ala Arg Phe Leu Arg Tyr Ser Asp Glu Asn 
                85                  90                  95      


Val Leu Ser Ile Val Tyr Leu Leu Thr Gly Tyr Leu Arg Tyr Leu Ile 
            100                 105                 110         


Asp Arg Lys Ser Leu Gly Ser Leu Arg His Asp Ile Asp Ile Glu Val 
        115                 120                 125             


Pro Gln Lys Glu Gln Tyr Ser Asn Asn Glu Lys Gly Asn Thr Val Asn 
    130                 135                 140                 


Arg Lys Tyr Gly Arg Ile Cys Cys Ile Ser Thr Leu Phe Leu Tyr Leu 
145                 150                 155                 160 


Leu Leu Phe Ala Gly Ile Gly Val Trp Tyr Gly Thr Thr Ala Gln Val 
                165                 170                 175     


Val Trp Arg Leu Pro Pro Leu Val Val Pro Ile Asp Asp Thr Glu Ile 
            180                 185                 190         


Ile Phe Trp Asp Cys Trp Ala Pro Glu Glu Pro Ala Cys Gln Asp Phe 
        195                 200                 205             


Leu Gly Ala Met Ile His Leu Lys Ala Asn Ile Asn Ile Ser Ile Gln 
    210                 215                 220                 


Glu Gly Pro Thr Leu Gly Asn Trp Ala Arg Glu Ile Trp Ser Thr Leu 
225                 230                 235                 240 


Phe Lys Lys Ala Thr Arg Gln Cys Arg Arg Gly Arg Ile Trp Arg Arg 
                245                 250                 255     


Trp Asn Glu Thr Ile Thr Gly Pro Leu Gly Cys Ala Asn Asn Thr Cys 
            260                 265                 270         


Tyr Asn Ile Ser Val Val Ile Pro Asp Tyr Gln Cys Tyr Val Asp Arg 
        275                 280                 285             


Val Asp Thr Trp Leu Gln Gly Lys Val Asn Ile Ser Leu Cys Leu Thr 
    290                 295                 300                 


Gly Gly Lys Met Leu Phe Asn Lys Glu Thr Lys Gln Leu Ser Tyr Cys 
305                 310                 315                 320 


Thr Asp Pro Leu Gln Ile Pro Leu Ile Asn Tyr Thr Phe Gly Pro Asn 
                325                 330                 335     


Gln Thr Cys Glu Trp Asn Thr Ser Leu Ile Lys Asp Pro Glu Ile Pro 
            340                 345                 350         


Lys Cys Gly Trp Trp Asn Gln Asn Ala Tyr Tyr Asn Ser Cys Lys Trp 
        355                 360                 365             


Glu Gln Thr Asp Val Lys Phe Gln Cys Gln Arg Ile Gln Ser Gln Pro 
    370                 375                 380                 


Gly Ser Trp Ile Arg Ala Ile Ser Ser Trp Arg Gln Arg Asn Arg Trp 
385                 390                 395                 400 


Glu Trp Arg Pro Asp Phe Glu Ser Glu Lys Val Lys Ile Ser Leu Gln 
                405                 410                 415     


Cys Asn Ser Thr Arg Asn Leu Thr Phe Ala Met Arg Ser Ser Ser Asp 
            420                 425                 430         


Tyr Tyr Asp Val Gln Gly Ala Trp Ile Glu Phe Gly Cys Tyr Arg Asn 
        435                 440                 445             


Lys Ser Ile Arg His Thr Gly Thr Arg Phe Arg Ile Arg Cys Arg Trp 
    450                 455                 460                 


Asn Glu Gly Lys Asn Met Ser Leu Ile Asp Thr Cys Gly Thr Asp Pro 
465                 470                 475                 480 


Asn Val Thr Arg Ala Asn Pro Val Asn Cys Thr Leu Lys Thr Asn Thr 
                485                 490                 495     


Met Tyr Asn Cys Thr Leu Gln Asp Ser Phe Thr Met Lys Ile Glu Asp 
            500                 505                 510         


Leu Ile Val His Phe Asn Met Ser Lys Ala Val Glu Met Tyr Asn Ile 
        515                 520                 525             


Ala Gly Asn Trp Ser Cys Thr Ser Asp Leu Pro Thr Gly Trp Gly Tyr 
    530                 535                 540                 


Met Lys Cys Asn Cys Thr Ser Thr Asn Asn Thr Gly Lys Met Lys Cys 
545                 550                 555                 560 


Pro Glu Pro Glu Gly Ile Leu Arg Asn Trp Tyr Asn Pro Val Ala Gly 
                565                 570                 575     


Leu Arg Gln Ala Leu Met Lys Tyr Gln Val Val Lys Gln Pro Glu Tyr 
            580                 585                 590         


Leu Ile Val Pro Glu Glu Val Met Lys Tyr Lys Ser Lys Gln Lys Arg 
        595                 600                 605             


Ala Ala Ile His Ile Met Leu Ala Leu Ala Thr Val Leu Ser Ile Ala 
    610                 615                 620                 


Gly Ala Gly Thr Gly Ala Thr Ala Ile Gly Met Val Thr Gln Tyr His 
625                 630                 635                 640 


Gln Val Leu Ala Thr His Gln Gln Ala Leu Glu Lys Ile Thr Glu Ala 
                645                 650                 655     


Leu Lys Ile Asn Asn Leu Arg Leu Val Thr Leu Glu His Gln Val Leu 
            660                 665                 670         


Met Ile Gly Leu Lys Val Glu Ala Ile Glu Lys Arg Leu Tyr Thr Ala 
        675                 680                 685             


Phe Ala Met Gln Glu Leu Gly Cys Asn Gln Asn Gln Phe Phe Cys Lys 
    690                 695                 700                 


Ile Pro Leu Asn Leu Trp Thr Met Tyr Asn Met Thr Ile Asn Gln Thr 
705                 710                 715                 720 


Leu Trp Asn His Gly Asn Ile Thr Leu Gly Asp Trp Tyr Asn Gln Thr 
                725                 730                 735     


Lys Gly Leu Gln Glu Lys Phe Tyr Glu Ile Ile Met Asp Leu Glu Gln 
            740                 745                 750         


Asn Asn Val Gln Gly Lys Leu Gly Ile Gln Gln Leu Gln Lys Trp Glu 
        755                 760                 765             


Asn Trp Val Gly Trp Ile Gly Lys Ile Pro Gln Tyr Leu Lys Gly Leu 
    770                 775                 780                 


Leu Gly Ser Val Leu Gly Ile Gly Val Gly Ile Leu Leu Leu Ile Ile 
785                 790                 795                 800 


Cys Leu Pro Thr Leu Val Asp Cys Ile Arg Asn Cys Ile Asn Lys Val 
                805                 810                 815     


Leu Gly Tyr Ser Val Ile Ala Met Pro Glu Leu Asp Asp Glu Glu Val 
            820                 825                 830         


Ser Met Glu Leu Arg Arg Asn Gly Arg Gln Cys Gly Met Ser Glu Lys 
        835                 840                 845             


Glu Glu Glu 
    850     


<210>  401
<211>  851
<212>  PRT
<213>  Artificial sequence

<220>
<223>  Mutated sequence

<400>  401

Met Ala Glu Gly Gly Phe Ala Gln Asn Gln Gln Trp Ile Gly Pro Glu 
1               5                   10                  15      


Glu Ala Glu Glu Leu Leu Asp Phe Asp Ile Ala Val Gln Met Asn Glu 
            20                  25                  30          


Glu Gly Pro Leu Asn Pro Gly Val Asn Pro Phe Arg Val Pro Gly Ile 
        35                  40                  45              


Thr Pro Gln Glu Lys Asp Asn Tyr Cys Thr Ile Leu Gln Pro Arg Leu 
    50                  55                  60                  


Gln Glu Leu Lys Arg Glu Ile Lys Glu Val Lys Ile Glu Glu Glu Asn 
65                  70                  75                  80  


Ala Gly Lys Phe Arg Arg Ala Arg Phe Leu Arg Tyr Ser Asp Glu Asn 
                85                  90                  95      


Val Leu Ser Ile Val Tyr Leu Leu Thr Gly Tyr Leu Arg Tyr Leu Ile 
            100                 105                 110         


Asp Arg Lys Ser Leu Gly Ser Leu Arg His Asp Ile Asp Ile Glu Val 
        115                 120                 125             


Pro Gln Lys Glu Gln Tyr Ser Asn Asn Glu Lys Gly Asn Thr Val Asn 
    130                 135                 140                 


Arg Lys Tyr Gly Arg Ile Cys Cys Ile Ser Thr Leu Phe Leu Tyr Leu 
145                 150                 155                 160 


Leu Leu Phe Ala Gly Ile Gly Val Trp Tyr Gly Thr Thr Ala Gln Val 
                165                 170                 175     


Val Trp Arg Leu Pro Pro Leu Val Val Pro Ile Asp Asp Thr Glu Ile 
            180                 185                 190         


Ile Phe Trp Asp Cys Trp Ala Pro Glu Glu Pro Ala Cys Gln Asp Phe 
        195                 200                 205             


Leu Gly Ala Met Ile His Leu Lys Ala Asn Ile Asn Ile Ser Ile Gln 
    210                 215                 220                 


Glu Gly Pro Thr Leu Gly Asn Trp Ala Arg Glu Ile Trp Ser Thr Leu 
225                 230                 235                 240 


Phe Lys Lys Ala Thr Arg Gln Cys Arg Arg Gly Arg Ile Trp Arg Arg 
                245                 250                 255     


Trp Asn Glu Thr Ile Thr Gly Pro Leu Gly Cys Ala Asn Asn Thr Cys 
            260                 265                 270         


Tyr Asn Ile Ser Val Val Ile Pro Asp Tyr Gln Cys Tyr Val Asp Arg 
        275                 280                 285             


Val Asp Thr Trp Leu Gln Gly Lys Val Asn Ile Ser Leu Cys Leu Thr 
    290                 295                 300                 


Gly Gly Lys Met Leu Phe Asn Lys Glu Thr Lys Gln Leu Ser Tyr Cys 
305                 310                 315                 320 


Thr Asp Pro Leu Gln Ile Pro Leu Ile Asn Tyr Thr Phe Gly Pro Asn 
                325                 330                 335     


Gln Thr Cys Glu Trp Asn Thr Ser Leu Ile Lys Asp Pro Glu Ile Pro 
            340                 345                 350         


Lys Cys Gly Trp Trp Asn Gln Asn Ala Tyr Tyr Asn Ser Cys Lys Trp 
        355                 360                 365             


Glu Gln Thr Asp Val Lys Phe Gln Cys Gln Arg Ile Gln Ser Gln Pro 
    370                 375                 380                 


Gly Ser Trp Ile Arg Ala Ile Ser Ser Trp Arg Gln Arg Asn Arg Trp 
385                 390                 395                 400 


Glu Trp Arg Pro Asp Phe Glu Ser Glu Lys Val Lys Ile Ser Leu Gln 
                405                 410                 415     


Cys Asn Ser Thr Arg Asn Leu Thr Phe Ala Met Arg Ser Ser Ser Asp 
            420                 425                 430         


Tyr Tyr Asp Val Gln Gly Ala Trp Ile Glu Phe Gly Cys Tyr Arg Asn 
        435                 440                 445             


Lys Ser Ile Arg His Thr Gly Thr Arg Phe Arg Ile Arg Cys Arg Trp 
    450                 455                 460                 


Asn Glu Gly Lys Asn Met Ser Leu Ile Asp Thr Cys Gly Thr Asp Pro 
465                 470                 475                 480 


Asn Val Thr Arg Ala Asn Pro Val Asn Cys Thr Leu Lys Thr Asn Thr 
                485                 490                 495     


Met Tyr Asn Cys Thr Leu Gln Asp Ser Phe Thr Met Lys Ile Glu Asp 
            500                 505                 510         


Leu Ile Val His Phe Asn Met Ser Lys Ala Val Glu Met Tyr Asn Ile 
        515                 520                 525             


Ala Gly Asn Trp Ser Cys Thr Ser Asp Leu Pro Thr Gly Trp Gly Tyr 
    530                 535                 540                 


Met Lys Cys Asn Cys Thr Ser Thr Asn Asn Thr Gly Lys Met Lys Cys 
545                 550                 555                 560 


Pro Glu Pro Glu Gly Ile Leu Arg Asn Trp Tyr Asn Pro Val Ala Gly 
                565                 570                 575     


Leu Arg Gln Ala Leu Met Lys Tyr Gln Val Val Lys Gln Pro Glu Tyr 
            580                 585                 590         


Leu Ile Val Pro Glu Glu Val Met Lys Tyr Lys Ser Lys Gln Lys Arg 
        595                 600                 605             


Ala Ala Ile His Ile Met Leu Ala Leu Ala Thr Val Leu Ser Ile Ala 
    610                 615                 620                 


Gly Ala Gly Thr Gly Ala Thr Ala Ile Gly Met Val Thr Gln Tyr His 
625                 630                 635                 640 


Gln Val Leu Ala Thr His Gln Gln Ala Leu Glu Lys Ile Thr Glu Ala 
                645                 650                 655     


Leu Lys Ile Asn Asn Leu Arg Leu Val Thr Leu Glu His Gln Val Leu 
            660                 665                 670         


Met Ile Gly Leu Lys Val Glu Ala Ile Glu Lys Phe Arg Tyr Thr Ala 
        675                 680                 685             


Phe Ala Met Gln Glu Leu Gly Cys Asn Gln Asn Gln Phe Phe Cys Lys 
    690                 695                 700                 


Ile Pro Leu Asn Leu Trp Thr Met Tyr Asn Met Thr Ile Asn Gln Thr 
705                 710                 715                 720 


Leu Trp Asn His Gly Asn Ile Thr Leu Gly Asp Trp Tyr Asn Gln Thr 
                725                 730                 735     


Lys Gly Leu Gln Glu Lys Phe Tyr Glu Ile Ile Met Asp Leu Glu Gln 
            740                 745                 750         


Asn Asn Val Gln Gly Lys Leu Gly Ile Gln Gln Leu Gln Lys Trp Glu 
        755                 760                 765             


Asn Trp Val Gly Trp Ile Gly Lys Ile Pro Gln Tyr Leu Lys Gly Leu 
    770                 775                 780                 


Leu Gly Ser Val Leu Gly Ile Gly Val Gly Ile Leu Leu Leu Ile Ile 
785                 790                 795                 800 


Cys Leu Pro Thr Leu Val Asp Cys Ile Arg Asn Cys Ile Asn Lys Val 
                805                 810                 815     


Leu Gly Tyr Ser Val Ile Ala Met Pro Glu Leu Asp Asp Glu Glu Val 
            820                 825                 830         


Ser Met Glu Leu Arg Arg Asn Gly Arg Gln Cys Gly Met Ser Glu Lys 
        835                 840                 845             


Glu Glu Glu 
    850     


<210>  402
<211>  855
<212>  PRT
<213>  Artificial sequence

<220>
<223>  Mutated sequence

<400>  402

Met Ala Glu Gly Gly Phe Thr Gln Asn His Gln Trp Ile Gly Pro Glu 
1               5                   10                  15      


Glu Ala Glu Glu Leu Leu Asp Phe Asp Ile Ala Ile Gln Met Asn Glu 
            20                  25                  30          


Glu Gly Pro Leu Asn Pro Gly Val Asn Pro Phe Arg Val Pro Gly Ile 
        35                  40                  45              


Thr Ser Gln Glu Lys Asp Asp Tyr Cys Lys Ile Leu Gln Thr Lys Leu 
    50                  55                  60                  


Gln Glu Leu Lys Asn Glu Val Lys Glu Val Lys Ile Glu Glu Gly Asn 
65                  70                  75                  80  


Ala Gly Lys Phe Arg Arg Ala Arg Phe Leu Arg Tyr Ser Asp Glu Asn 
                85                  90                  95      


Val Leu Ser Ile Val Tyr Leu Leu Ile Gly Tyr Leu Arg Tyr Leu Ile 
            100                 105                 110         


Asp His Arg Ser Leu Gly Ser Leu Arg His Asp Ile Asp Ile Glu Ala 
        115                 120                 125             


Pro Gln Glu Glu His Tyr Asn Asn Ser Glu Lys Gly Thr Thr Leu Asn 
    130                 135                 140                 


Ile Lys Tyr Gly Arg Arg Cys Cys Ile Ser Thr Phe Ile Met Tyr Leu 
145                 150                 155                 160 


Ile Leu Phe Ala Gly Val Gly Ile Trp Phe Gly Ala Arg Ala Gln Val 
                165                 170                 175     


Val Trp Arg Leu Pro Pro Leu Val Val Pro Val Asp Asp Thr Glu Ile 
            180                 185                 190         


Ile Phe Trp Asp Cys Trp Ala Pro Glu Glu Pro Ala Cys Gln Asp Phe 
        195                 200                 205             


Leu Gly Thr Met Ile His Leu Lys Ala Lys Thr Asn Ile Ser Ile Gln 
    210                 215                 220                 


Glu Gly Pro Thr Leu Gly Asn Trp Ala Arg Glu Ile Trp Ala Thr Leu 
225                 230                 235                 240 


Phe Lys Lys Ala Thr Arg Gln Cys Arg Arg Gly Arg Ile Trp Arg Arg 
                245                 250                 255     


Trp Asn Glu Thr Ile Thr Gly Pro Leu Gly Cys Ala Asn Asn Thr Cys 
            260                 265                 270         


Tyr Asn Ile Ser Val Val Val Pro Asp Tyr Gln Cys Tyr Leu Asp Arg 
        275                 280                 285             


Val Asp Thr Trp Leu Gln Gly Lys Leu Asn Ile Ser Leu Cys Leu Thr 
    290                 295                 300                 


Gly Gly Lys Met Leu Tyr Asn Lys Val Thr Lys Gln Leu Ser Tyr Cys 
305                 310                 315                 320 


Thr Asp Pro Leu Gln Ile Pro Leu Ile Asn Tyr Thr Phe Gly Pro Asn 
                325                 330                 335     


Gln Thr Cys Met Trp Asn Thr Ser Gln Ile Gln Asp Pro Glu Ile Pro 
            340                 345                 350         


Lys Cys Gly Trp Trp Asn Gln Met Ala Tyr Tyr Asn Ser Cys Lys Trp 
        355                 360                 365             


Glu Glu Ala Lys Val Lys Phe His Cys Gln Arg Thr Gln Ser Gln Pro 
    370                 375                 380                 


Gly Ser Trp His Arg Ala Ile Ser Ser Trp Lys Gln Arg Asn Arg Trp 
385                 390                 395                 400 


Glu Trp Arg Pro Asp Phe Lys Ser Lys Lys Val Lys Ile Ser Leu Gln 
                405                 410                 415     


Cys Asn Ser Thr Lys Asn Leu Thr Phe Ala Met Arg Ser Ser Ser Asp 
            420                 425                 430         


Tyr Tyr Asp Val Gln Gly Ala Trp Ile Glu Phe Gly Cys His Arg Asn 
        435                 440                 445             


Lys Ser Lys Gly Phe Ser Glu Ala Arg Phe Arg Thr Arg Cys Lys Trp 
    450                 455                 460                 


Asn Glu Gly Asn Asn Ile Ser Leu Ile Asp Thr Cys Gly Thr Asn Pro 
465                 470                 475                 480 


Asn Val Thr Gly Ala Asn Pro Val Asp Cys Thr Met Lys Ala Asn Ile 
                485                 490                 495     


Met Tyr Asn Cys Ser Leu Gln Asp Ser Phe Thr Met Lys Ile Glu Asp 
            500                 505                 510         


Leu Ile Val His Phe Asn Met Thr Lys Ala Val Glu Met Tyr Asn Ile 
        515                 520                 525             


Ala Gly Asn Trp Ser Cys Thr Ser Asp Leu Pro Lys Gly Trp Gly Tyr 
    530                 535                 540                 


Met Asn Cys Asn Cys Thr Asn Gly Thr Asp Asn Ser Lys Thr Lys Met 
545                 550                 555                 560 


Ala Cys Pro Arg Asn Gln Gly Ile Leu Arg Asn Trp Tyr Asn Pro Val 
                565                 570                 575     


Ala Gly Leu Arg Gln Ala Leu Ile Lys Tyr Gln Val Val Lys Gln Pro 
            580                 585                 590         


Glu Tyr Leu Ile Val Pro Glu Glu Val Met Gln Tyr Lys Val Lys Gln 
        595                 600                 605             


Lys Arg Ala Ala Ile His Ile Met Leu Ala Leu Ala Thr Val Leu Ser 
    610                 615                 620                 


Met Ala Gly Ala Gly Thr Gly Ala Thr Ala Ile Gly Met Val Thr Gln 
625                 630                 635                 640 


Tyr His Gln Val Leu Ala Thr His Gln His Ala Leu Asp Lys Ile Thr 
                645                 650                 655     


Glu Ala Leu Lys Ile Asn Asn Leu Arg Leu Ile Thr Leu Val His Gln 
            660                 665                 670         


Val Leu Val Ile Gly Leu Lys Val Arg Ala Ile Glu Lys Arg Leu Tyr 
        675                 680                 685             


Thr Ala Phe Ala Met Gln Glu Leu Gly Cys Asn Gln Asn Gln Phe Phe 
    690                 695                 700                 


Cys Lys Ile Pro Pro Ser Leu Trp Ser Met Tyr Asn Met Thr Leu Asn 
705                 710                 715                 720 


Gln Thr Ile Trp Asn His Gly Asn Ile Ser Leu Gly Asn Trp Tyr Asn 
                725                 730                 735     


Gln Thr Arg Asp Leu Gln Asn Lys Phe Tyr Glu Ile Ile Met Asp Ile 
            740                 745                 750         


Glu Gln Asn Asn Val Gln Gly Lys Thr Gly Ile Gln Gln Leu Gln Lys 
        755                 760                 765             


Trp Glu Asn Trp Val Gly Trp Ile Gly Lys Ile Pro Gln Tyr Leu Lys 
    770                 775                 780                 


Gly Leu Leu Gly Ser Val Leu Gly Ile Gly Leu Gly Ile Leu Leu Leu 
785                 790                 795                 800 


Leu Ile Cys Leu Pro Thr Leu Val Asp Cys Ile Arg Asn Cys Thr His 
                805                 810                 815     


Lys Ile Leu Gly Tyr Thr Val Ile Ala Met Pro Glu Ile Asp Asp Glu 
            820                 825                 830         


Glu Val His Leu Ser Val Glu Leu Arg Arg Asn Gly Arg Gln Cys Gly 
        835                 840                 845             


Ile Ser Glu Lys Glu Glu Glu 
    850                 855 


<210>  403
<211>  855
<212>  PRT
<213>  Artificial sequence

<220>
<223>  Mutated sequence

<400>  403

Met Ala Glu Gly Gly Phe Thr Gln Asn His Gln Trp Ile Gly Pro Glu 
1               5                   10                  15      


Glu Ala Glu Glu Leu Leu Asp Phe Asp Ile Ala Ile Gln Met Asn Glu 
            20                  25                  30          


Glu Gly Pro Leu Asn Pro Gly Val Asn Pro Phe Arg Val Pro Gly Ile 
        35                  40                  45              


Thr Ser Gln Glu Lys Asp Asp Tyr Cys Lys Ile Leu Gln Thr Lys Leu 
    50                  55                  60                  


Gln Glu Leu Lys Asn Glu Val Lys Glu Val Lys Ile Glu Glu Gly Asn 
65                  70                  75                  80  


Ala Gly Lys Phe Arg Arg Ala Arg Phe Leu Arg Tyr Ser Asp Glu Asn 
                85                  90                  95      


Val Leu Ser Ile Val Tyr Leu Leu Ile Gly Tyr Leu Arg Tyr Leu Ile 
            100                 105                 110         


Asp His Arg Ser Leu Gly Ser Leu Arg His Asp Ile Asp Ile Glu Ala 
        115                 120                 125             


Pro Gln Glu Glu His Tyr Asn Asn Ser Glu Lys Gly Thr Thr Leu Asn 
    130                 135                 140                 


Ile Lys Tyr Gly Arg Arg Cys Cys Ile Ser Thr Phe Ile Met Tyr Leu 
145                 150                 155                 160 


Ile Leu Phe Ala Gly Val Gly Ile Trp Phe Gly Ala Arg Ala Gln Val 
                165                 170                 175     


Val Trp Arg Leu Pro Pro Leu Val Val Pro Val Asp Asp Thr Glu Ile 
            180                 185                 190         


Ile Phe Trp Asp Cys Trp Ala Pro Glu Glu Pro Ala Cys Gln Asp Phe 
        195                 200                 205             


Leu Gly Thr Met Ile His Leu Lys Ala Lys Thr Asn Ile Ser Ile Gln 
    210                 215                 220                 


Glu Gly Pro Thr Leu Gly Asn Trp Ala Arg Glu Ile Trp Ala Thr Leu 
225                 230                 235                 240 


Phe Lys Lys Ala Thr Arg Gln Cys Arg Arg Gly Arg Ile Trp Arg Arg 
                245                 250                 255     


Trp Asn Glu Thr Ile Thr Gly Pro Leu Gly Cys Ala Asn Asn Thr Cys 
            260                 265                 270         


Tyr Asn Ile Ser Val Val Val Pro Asp Tyr Gln Cys Tyr Leu Asp Arg 
        275                 280                 285             


Val Asp Thr Trp Leu Gln Gly Lys Leu Asn Ile Ser Leu Cys Leu Thr 
    290                 295                 300                 


Gly Gly Lys Met Leu Tyr Asn Lys Val Thr Lys Gln Leu Ser Tyr Cys 
305                 310                 315                 320 


Thr Asp Pro Leu Gln Ile Pro Leu Ile Asn Tyr Thr Phe Gly Pro Asn 
                325                 330                 335     


Gln Thr Cys Met Trp Asn Thr Ser Gln Ile Gln Asp Pro Glu Ile Pro 
            340                 345                 350         


Lys Cys Gly Trp Trp Asn Gln Met Ala Tyr Tyr Asn Ser Cys Lys Trp 
        355                 360                 365             


Glu Glu Ala Lys Val Lys Phe His Cys Gln Arg Thr Gln Ser Gln Pro 
    370                 375                 380                 


Gly Ser Trp His Arg Ala Ile Ser Ser Trp Lys Gln Arg Asn Arg Trp 
385                 390                 395                 400 


Glu Trp Arg Pro Asp Phe Lys Ser Lys Lys Val Lys Ile Ser Leu Gln 
                405                 410                 415     


Cys Asn Ser Thr Lys Asn Leu Thr Phe Ala Met Arg Ser Ser Ser Asp 
            420                 425                 430         


Tyr Tyr Asp Val Gln Gly Ala Trp Ile Glu Phe Gly Cys His Arg Asn 
        435                 440                 445             


Lys Ser Lys Gly Phe Ser Glu Ala Arg Phe Arg Thr Arg Cys Lys Trp 
    450                 455                 460                 


Asn Glu Gly Asn Asn Ile Ser Leu Ile Asp Thr Cys Gly Thr Asn Pro 
465                 470                 475                 480 


Asn Val Thr Gly Ala Asn Pro Val Asp Cys Thr Met Lys Ala Asn Ile 
                485                 490                 495     


Met Tyr Asn Cys Ser Leu Gln Asp Ser Phe Thr Met Lys Ile Glu Asp 
            500                 505                 510         


Leu Ile Val His Phe Asn Met Thr Lys Ala Val Glu Met Tyr Asn Ile 
        515                 520                 525             


Ala Gly Asn Trp Ser Cys Thr Ser Asp Leu Pro Lys Gly Trp Gly Tyr 
    530                 535                 540                 


Met Asn Cys Asn Cys Thr Asn Gly Thr Asp Asn Ser Lys Thr Lys Met 
545                 550                 555                 560 


Ala Cys Pro Arg Asn Gln Gly Ile Leu Arg Asn Trp Tyr Asn Pro Val 
                565                 570                 575     


Ala Gly Leu Arg Gln Ala Leu Ile Lys Tyr Gln Val Val Lys Gln Pro 
            580                 585                 590         


Glu Tyr Leu Ile Val Pro Glu Glu Val Met Gln Tyr Lys Val Lys Gln 
        595                 600                 605             


Lys Arg Ala Ala Ile His Ile Met Leu Ala Leu Ala Thr Val Leu Ser 
    610                 615                 620                 


Met Ala Gly Ala Gly Thr Gly Ala Thr Ala Ile Gly Met Val Thr Gln 
625                 630                 635                 640 


Tyr His Gln Val Leu Ala Thr His Gln His Ala Leu Asp Lys Ile Thr 
                645                 650                 655     


Glu Ala Leu Lys Ile Asn Asn Leu Arg Leu Ile Thr Leu Val His Gln 
            660                 665                 670         


Val Leu Val Ile Gly Leu Lys Val Arg Ala Ile Glu Lys Pro Arg Tyr 
        675                 680                 685             


Thr Ala Phe Ala Met Gln Glu Leu Gly Cys Asn Gln Asn Gln Phe Phe 
    690                 695                 700                 


Cys Lys Ile Pro Pro Ser Leu Trp Ser Met Tyr Asn Met Thr Leu Asn 
705                 710                 715                 720 


Gln Thr Ile Trp Asn His Gly Asn Ile Ser Leu Gly Asn Trp Tyr Asn 
                725                 730                 735     


Gln Thr Arg Asp Leu Gln Asn Lys Phe Tyr Glu Ile Ile Met Asp Ile 
            740                 745                 750         


Glu Gln Asn Asn Val Gln Gly Lys Thr Gly Ile Gln Gln Leu Gln Lys 
        755                 760                 765             


Trp Glu Asn Trp Val Gly Trp Ile Gly Lys Ile Pro Gln Tyr Leu Lys 
    770                 775                 780                 


Gly Leu Leu Gly Ser Val Leu Gly Ile Gly Leu Gly Ile Leu Leu Leu 
785                 790                 795                 800 


Leu Ile Cys Leu Pro Thr Leu Val Asp Cys Ile Arg Asn Cys Thr His 
                805                 810                 815     


Lys Ile Leu Gly Tyr Thr Val Ile Ala Met Pro Glu Ile Asp Asp Glu 
            820                 825                 830         


Glu Val His Leu Ser Val Glu Leu Arg Arg Asn Gly Arg Gln Cys Gly 
        835                 840                 845             


Ile Ser Glu Lys Glu Glu Glu 
    850                 855 


<210>  404
<211>  854
<212>  PRT
<213>  Artificial sequence

<220>
<223>  Mutated sequence

<400>  404

Met Ala Glu Gly Phe Ala Ala Asn Arg Gln Trp Ile Gly Pro Glu Glu 
1               5                   10                  15      


Ala Glu Glu Leu Leu Asp Phe Asp Lys Ala Thr Gln Met Asn Glu Glu 
            20                  25                  30          


Gly Pro Leu Asn Pro Gly Val Asn Pro Phe Arg Val Pro Ala Val Thr 
        35                  40                  45              


Glu Ala Asp Lys Gln Glu Tyr Cys Lys Ile Leu Gln Pro Arg Leu Gln 
    50                  55                  60                  


Glu Ile Arg Asn Glu Ile Gln Glu Val Lys Leu Glu Glu Gly Asn Ala 
65                  70                  75                  80  


Gly Lys Phe Arg Arg Ala Arg Phe Leu Arg Tyr Ser Asp Glu Ser Ile 
                85                  90                  95      


Leu Ser Leu Ile His Leu Phe Ile Gly Tyr Cys Thr Tyr Leu Val Asn 
            100                 105                 110         


Arg Arg Arg Leu Gly Ser Leu Arg His Asp Ile Asn Ile Glu Ala Pro 
        115                 120                 125             


Gln Glu Glu Gln Tyr Ser Ser Arg Glu Gln Gly Thr Thr Glu Asn Ile 
    130                 135                 140                 


Lys Tyr Gly Arg Arg Cys Leu Ile Gly Thr Ala Ser Leu Tyr Leu Leu 
145                 150                 155                 160 


Leu Phe Ile Gly Val Ala Ile Tyr Leu Gly Thr Thr Asn Ala Gln Ile 
                165                 170                 175     


Val Trp Arg Leu Pro Pro Leu Val Val Pro Val Glu Glu Ser Glu Ile 
            180                 185                 190         


Ile Phe Trp Asp Cys Trp Ala Pro Glu Glu Pro Ala Cys Gln Asp Phe 
        195                 200                 205             


Leu Gly Ala Met Ile His Leu Lys Ala Ser Thr Asn Ile Ser Ile Gln 
    210                 215                 220                 


Glu Gly Pro Thr Leu Gly Asn Trp Ala Arg Glu Ile Trp Gly Thr Leu 
225                 230                 235                 240 


Phe Lys Lys Ala Thr Arg His Cys Arg Arg Asn Lys Ile Trp Lys Arg 
                245                 250                 255     


Trp Asn Glu Thr Ile Thr Gly Pro Val Gly Cys Ala Asn Asn Thr Cys 
            260                 265                 270         


Tyr Asn Ile Ser Val Ile Ile Pro Asp Tyr Gln Cys Tyr Leu Asp Arg 
        275                 280                 285             


Val Asp Thr Trp Leu Gln Gly Lys Val Asn Ile Ser Leu Cys Leu Thr 
    290                 295                 300                 


Gly Gly Lys Met Leu Tyr Asn Arg Asp Thr Lys Gln Leu Ser Tyr Cys 
305                 310                 315                 320 


Thr Asp Pro Leu Gln Ile Pro Leu Ile Asn Tyr Thr Phe Gly Pro Asn 
                325                 330                 335     


Gln Thr Cys Met Trp Asn Thr Ser Gln Ile Gln Asp Pro Glu Ile Pro 
            340                 345                 350         


Lys Cys Gly Trp Trp Asn Gln Ile Ala Tyr Tyr Asn Ser Cys Arg Trp 
        355                 360                 365             


Glu Ser Thr Asn Val Lys Phe Tyr Cys Gln Arg Thr Gln Ser Gln Pro 
    370                 375                 380                 


Gly Thr Trp Ile Arg Thr Ile Ser Ser Trp Arg Gln Lys Asn Arg Trp 
385                 390                 395                 400 


Glu Trp Arg Pro Asp Phe Glu Ser Glu Lys Val Lys Ile Ser Leu Gln 
                405                 410                 415     


Cys Asn Ser Thr His Asn Leu Thr Phe Ala Met Arg Ser Ser Gly Asp 
            420                 425                 430         


Tyr Gly Glu Val Met Gly Ala Trp Ile Glu Phe Gly Cys His Arg Asn 
        435                 440                 445             


Lys Ser Arg Phe His Thr Glu Ala Arg Phe Arg Ile Arg Cys Arg Trp 
    450                 455                 460                 


Asn Val Gly Asp Asn Thr Ser Leu Ile Asp Thr Cys Gly Lys Asn Leu 
465                 470                 475                 480 


Asn Val Ser Gly Ala Asn Pro Val Asp Cys Thr Met Tyr Ala Asn Lys 
                485                 490                 495     


Met Tyr Asn Cys Ser Leu Gln Asn Gly Phe Thr Met Lys Val Asp Asp 
            500                 505                 510         


Leu Ile Met His Phe Asn Met Thr Lys Ala Val Glu Met Tyr Asn Ile 
        515                 520                 525             


Ala Gly Asn Trp Ser Cys Lys Ser Asp Leu Pro Gln Asn Trp Gly Tyr 
    530                 535                 540                 


Met Asn Cys Asn Cys Thr Asn Gly Thr Ser Asn Asp Asn Lys Met Ala 
545                 550                 555                 560 


Cys Pro Glu Asp Lys Gly Ile Leu Arg Asn Trp Tyr Asn Pro Val Ala 
                565                 570                 575     


Gly Leu Arg Gln Ala Leu Glu Lys Tyr Gln Val Val Lys Gln Pro Glu 
            580                 585                 590         


Tyr Ile Val Val Pro Thr Glu Val Met Thr Tyr Lys Tyr Lys Gln Lys 
        595                 600                 605             


Arg Ala Ala Ile His Ile Met Leu Ala Leu Ala Thr Val Leu Ser Ile 
    610                 615                 620                 


Ala Gly Ala Gly Thr Gly Ala Thr Ala Ile Gly Met Val Thr Gln Tyr 
625                 630                 635                 640 


Gln Gln Val Leu Ala Thr His Gln Glu Ala Leu Asp Lys Ile Thr Glu 
                645                 650                 655     


Ala Leu Lys Ile Asn Asn Leu Arg Leu Val Thr Leu Glu His Gln Met 
            660                 665                 670         


Leu Val Ile Gly Leu Lys Val Glu Ala Ile Glu Lys Arg Leu Tyr Thr 
        675                 680                 685             


Ala Phe Ala Met Gln Glu Leu Gly Cys Asn Gln Asn Gln Phe Phe Cys 
    690                 695                 700                 


Glu Ile Pro Lys Glu Leu Trp Leu Arg Tyr Asn Met Thr Leu Asn Gln 
705                 710                 715                 720 


Thr Ile Trp Asn His Gly Asn Ile Thr Leu Gly Glu Trp Tyr Asn Gln 
                725                 730                 735     


Thr Lys Tyr Leu Gln Gln Lys Phe Tyr Glu Ile Ile Met Asp Ile Glu 
            740                 745                 750         


Gln Asn Asn Val Gln Gly Lys Gln Gly Leu Gln Lys Leu Gln Asn Trp 
        755                 760                 765             


Gln Asp Trp Met Gly Trp Ile Gly Lys Ile Pro Gln Tyr Leu Lys Gly 
    770                 775                 780                 


Leu Leu Gly Gly Ile Leu Gly Ile Gly Leu Gly Ile Leu Leu Leu Ile 
785                 790                 795                 800 


Leu Cys Leu Pro Thr Leu Val Asp Cys Ile Arg Asn Cys Ile Ser Lys 
                805                 810                 815     


Val Leu Gly Tyr Thr Val Ile Ala Met Pro Glu Ile Asp Asp Glu Glu 
            820                 825                 830         


Glu Thr Val Gln Met Glu Leu Arg Lys Asn Gly Arg Gln Cys Gly Met 
        835                 840                 845             


Ser Glu Lys Glu Glu Glu 
    850                 


<210>  405
<211>  854
<212>  PRT
<213>  Artificial sequence

<220>
<223>  Mutated sequence

<400>  405

Met Ala Glu Gly Phe Ala Ala Asn Arg Gln Trp Ile Gly Pro Glu Glu 
1               5                   10                  15      


Ala Glu Glu Leu Leu Asp Phe Asp Lys Ala Thr Gln Met Asn Glu Glu 
            20                  25                  30          


Gly Pro Leu Asn Pro Gly Val Asn Pro Phe Arg Val Pro Ala Val Thr 
        35                  40                  45              


Glu Ala Asp Lys Gln Glu Tyr Cys Lys Ile Leu Gln Pro Arg Leu Gln 
    50                  55                  60                  


Glu Ile Arg Asn Glu Ile Gln Glu Val Lys Leu Glu Glu Gly Asn Ala 
65                  70                  75                  80  


Gly Lys Phe Arg Arg Ala Arg Phe Leu Arg Tyr Ser Asp Glu Ser Ile 
                85                  90                  95      


Leu Ser Leu Ile His Leu Phe Ile Gly Tyr Cys Thr Tyr Leu Val Asn 
            100                 105                 110         


Arg Arg Arg Leu Gly Ser Leu Arg His Asp Ile Asn Ile Glu Ala Pro 
        115                 120                 125             


Gln Glu Glu Gln Tyr Ser Ser Arg Glu Gln Gly Thr Thr Glu Asn Ile 
    130                 135                 140                 


Lys Tyr Gly Arg Arg Cys Leu Ile Gly Thr Ala Ser Leu Tyr Leu Leu 
145                 150                 155                 160 


Leu Phe Ile Gly Val Ala Ile Tyr Leu Gly Thr Thr Asn Ala Gln Ile 
                165                 170                 175     


Val Trp Arg Leu Pro Pro Leu Val Val Pro Val Glu Glu Ser Glu Ile 
            180                 185                 190         


Ile Phe Trp Asp Cys Trp Ala Pro Glu Glu Pro Ala Cys Gln Asp Phe 
        195                 200                 205             


Leu Gly Ala Met Ile His Leu Lys Ala Ser Thr Asn Ile Ser Ile Gln 
    210                 215                 220                 


Glu Gly Pro Thr Leu Gly Asn Trp Ala Arg Glu Ile Trp Gly Thr Leu 
225                 230                 235                 240 


Phe Lys Lys Ala Thr Arg His Cys Arg Arg Asn Lys Ile Trp Lys Arg 
                245                 250                 255     


Trp Asn Glu Thr Ile Thr Gly Pro Val Gly Cys Ala Asn Asn Thr Cys 
            260                 265                 270         


Tyr Asn Ile Ser Val Ile Ile Pro Asp Tyr Gln Cys Tyr Leu Asp Arg 
        275                 280                 285             


Val Asp Thr Trp Leu Gln Gly Lys Val Asn Ile Ser Leu Cys Leu Thr 
    290                 295                 300                 


Gly Gly Lys Met Leu Tyr Asn Arg Asp Thr Lys Gln Leu Ser Tyr Cys 
305                 310                 315                 320 


Thr Asp Pro Leu Gln Ile Pro Leu Ile Asn Tyr Thr Phe Gly Pro Asn 
                325                 330                 335     


Gln Thr Cys Met Trp Asn Thr Ser Gln Ile Gln Asp Pro Glu Ile Pro 
            340                 345                 350         


Lys Cys Gly Trp Trp Asn Gln Ile Ala Tyr Tyr Asn Ser Cys Arg Trp 
        355                 360                 365             


Glu Ser Thr Asn Val Lys Phe Tyr Cys Gln Arg Thr Gln Ser Gln Pro 
    370                 375                 380                 


Gly Thr Trp Ile Arg Thr Ile Ser Ser Trp Arg Gln Lys Asn Arg Trp 
385                 390                 395                 400 


Glu Trp Arg Pro Asp Phe Glu Ser Glu Lys Val Lys Ile Ser Leu Gln 
                405                 410                 415     


Cys Asn Ser Thr His Asn Leu Thr Phe Ala Met Arg Ser Ser Gly Asp 
            420                 425                 430         


Tyr Gly Glu Val Met Gly Ala Trp Ile Glu Phe Gly Cys His Arg Asn 
        435                 440                 445             


Lys Ser Arg Phe His Thr Glu Ala Arg Phe Arg Ile Arg Cys Arg Trp 
    450                 455                 460                 


Asn Val Gly Asp Asn Thr Ser Leu Ile Asp Thr Cys Gly Lys Asn Leu 
465                 470                 475                 480 


Asn Val Ser Gly Ala Asn Pro Val Asp Cys Thr Met Tyr Ala Asn Lys 
                485                 490                 495     


Met Tyr Asn Cys Ser Leu Gln Asn Gly Phe Thr Met Lys Val Asp Asp 
            500                 505                 510         


Leu Ile Met His Phe Asn Met Thr Lys Ala Val Glu Met Tyr Asn Ile 
        515                 520                 525             


Ala Gly Asn Trp Ser Cys Lys Ser Asp Leu Pro Gln Asn Trp Gly Tyr 
    530                 535                 540                 


Met Asn Cys Asn Cys Thr Asn Gly Thr Ser Asn Asp Asn Lys Met Ala 
545                 550                 555                 560 


Cys Pro Glu Asp Lys Gly Ile Leu Arg Asn Trp Tyr Asn Pro Val Ala 
                565                 570                 575     


Gly Leu Arg Gln Ala Leu Glu Lys Tyr Gln Val Val Lys Gln Pro Glu 
            580                 585                 590         


Tyr Ile Val Val Pro Thr Glu Val Met Thr Tyr Lys Tyr Lys Gln Lys 
        595                 600                 605             


Arg Ala Ala Ile His Ile Met Leu Ala Leu Ala Thr Val Leu Ser Ile 
    610                 615                 620                 


Ala Gly Ala Gly Thr Gly Ala Thr Ala Ile Gly Met Val Thr Gln Tyr 
625                 630                 635                 640 


Gln Gln Val Leu Ala Thr His Gln Glu Ala Leu Asp Lys Ile Thr Glu 
                645                 650                 655     


Ala Leu Lys Ile Asn Asn Leu Arg Leu Val Thr Leu Glu His Gln Met 
            660                 665                 670         


Leu Val Ile Gly Leu Lys Val Glu Ala Ile Glu Lys Phe Arg Tyr Thr 
        675                 680                 685             


Ala Phe Ala Met Gln Glu Leu Gly Cys Asn Gln Asn Gln Phe Phe Cys 
    690                 695                 700                 


Glu Ile Pro Lys Glu Leu Trp Leu Arg Tyr Asn Met Thr Leu Asn Gln 
705                 710                 715                 720 


Thr Ile Trp Asn His Gly Asn Ile Thr Leu Gly Glu Trp Tyr Asn Gln 
                725                 730                 735     


Thr Lys Tyr Leu Gln Gln Lys Phe Tyr Glu Ile Ile Met Asp Ile Glu 
            740                 745                 750         


Gln Asn Asn Val Gln Gly Lys Gln Gly Leu Gln Lys Leu Gln Asn Trp 
        755                 760                 765             


Gln Asp Trp Met Gly Trp Ile Gly Lys Ile Pro Gln Tyr Leu Lys Gly 
    770                 775                 780                 


Leu Leu Gly Gly Ile Leu Gly Ile Gly Leu Gly Ile Leu Leu Leu Ile 
785                 790                 795                 800 


Leu Cys Leu Pro Thr Leu Val Asp Cys Ile Arg Asn Cys Ile Ser Lys 
                805                 810                 815     


Val Leu Gly Tyr Thr Val Ile Ala Met Pro Glu Ile Asp Asp Glu Glu 
            820                 825                 830         


Glu Thr Val Gln Met Glu Leu Arg Lys Asn Gly Arg Gln Cys Gly Met 
        835                 840                 845             


Ser Glu Lys Glu Glu Glu 
    850                 


<210>  406
<211>  855
<212>  PRT
<213>  Artificial sequence

<220>
<223>  Mutated sequence

<400>  406

Met Ala Glu Gly Gly Phe Thr Gln Asn Gln Gln Trp Ile Gly Pro Glu 
1               5                   10                  15      


Glu Ala Glu Glu Leu Leu Asp Phe Asp Ile Ala Val Gln Met Asn Glu 
            20                  25                  30          


Glu Gly Pro Leu Asn Pro Gly Val Asn Pro Phe Arg Val Pro Gly Ile 
        35                  40                  45              


Thr Ser Gln Glu Lys Glu Asp Tyr Cys Lys Ile Leu Gln Thr Lys Leu 
    50                  55                  60                  


Gln Glu Leu Lys Asn Glu Val Lys Gly Val Lys Ile Glu Glu Gly Asn 
65                  70                  75                  80  


Ala Gly Lys Phe Arg Arg Ala Arg Tyr Leu Arg Tyr Ser Asp Glu Asn 
                85                  90                  95      


Val Leu Ser Ile Val Tyr Leu Leu Ile Gly Tyr Leu Arg Tyr Leu Ile 
            100                 105                 110         


Asp His Arg Ser Leu Gly Ser Leu Arg His Asp Ile Asp Ile Glu Thr 
        115                 120                 125             


Pro Gln Glu Glu His Phe Asn Asn Ser Glu Lys Gly Thr Thr Leu Asn 
    130                 135                 140                 


Thr Lys Tyr Gly Arg Arg Cys Cys Leu Ser Thr Phe Ile Met Asn Leu 
145                 150                 155                 160 


Ile Leu Phe Ala Gly Val Gly Ile Trp Leu Gly Ala Arg Ala Gln Val 
                165                 170                 175     


Val Trp Arg Leu Pro Pro Leu Val Val Pro Val Asp Asp Thr Glu Ile 
            180                 185                 190         


Ile Phe Trp Asp Cys Trp Ala Pro Glu Glu Pro Ala Cys Gln Asp Phe 
        195                 200                 205             


Leu Gly Thr Met Val Gln Leu Lys Ala Ser Ile Asn Ile Ser Ile Gln 
    210                 215                 220                 


Glu Gly Pro Thr Leu Gly His Trp Ala Arg Glu Ile Leu Glu Thr Leu 
225                 230                 235                 240 


Phe Lys Lys Ala Thr Arg Gln Cys Arg Arg Gly Arg Val Trp Arg Arg 
                245                 250                 255     


Trp Asn Glu Thr Ile Thr Gly Pro Leu Gly Cys Ala Asn Asn Ala Cys 
            260                 265                 270         


Tyr Asn Ile Ser Val Val Val Pro Asp Tyr Gln Cys Tyr Val Asp Arg 
        275                 280                 285             


Val Asp Thr Trp Leu Gln Gly Arg Ile Asn Ile Ser Leu Cys Leu Thr 
    290                 295                 300                 


Gly Gly Lys Met Leu Tyr Asn Lys Asp Thr Gln Gln Leu Ser Tyr Cys 
305                 310                 315                 320 


Thr Glu Pro Leu Gln Ile Pro Leu Ile Asn Tyr Thr Phe Gly Pro Asn 
                325                 330                 335     


Gln Thr Cys Met Trp Asn Thr Ser Leu Ile Glu Asp Ser Glu Ile Pro 
            340                 345                 350         


Lys Cys Gly Trp Trp Asn Gln Ala Ala Tyr Tyr Asn Ser Cys Lys Trp 
        355                 360                 365             


Glu Gln Thr Asp Val Lys Phe Gln Cys Gln Arg Thr Gln Ser Gln Pro 
    370                 375                 380                 


Gly Thr Trp Leu Arg Ala Ile Ala Ser Trp Glu Gln Ala Asn Arg Trp 
385                 390                 395                 400 


Ile Trp Arg Pro Asp Phe Glu Ser Asp Lys Val Lys Ile Ser Leu Gln 
                405                 410                 415     


Cys Asn Ser Thr Lys Asn Leu Thr Phe Ala Met Arg Ser Ser Ser Asp 
            420                 425                 430         


Tyr Tyr Asp Val Gln Gly Ala Trp Ile Glu Phe Gly Cys His Arg Asn 
        435                 440                 445             


Lys Ser Arg Arg His Ser Glu Ala Arg Phe Arg Ile Arg Cys Lys Trp 
    450                 455                 460                 


Asn Glu Gly Lys Asn Ile Ser Leu Ile Asp Thr Cys Gly Thr Asn Pro 
465                 470                 475                 480 


Asn Val Thr Gly Ala Asn Pro Val Asp Cys Thr Met Lys Ala Asn Thr 
                485                 490                 495     


Met Tyr Asn Cys Ser Leu Gln Asp Ser Phe Thr Met Lys Ile Glu Asp 
            500                 505                 510         


Leu Ile Val His Phe Asn Met Thr Lys Ala Val Glu Met Tyr Asn Ile 
        515                 520                 525             


Ala Gly Asn Trp Ser Cys Thr Ser Asp Leu Pro Lys Gly Trp Gly Tyr 
    530                 535                 540                 


Met Asn Cys Asn Cys Thr Asn Gly Thr Asp Asp Ser Lys Thr Lys Met 
545                 550                 555                 560 


Ala Cys Pro Glu Asn Gln Gly Ile Leu Arg Asn Trp Tyr Asn Pro Val 
                565                 570                 575     


Ala Gly Leu Arg Gln Ala Leu Ile Lys Tyr His Val Val Lys Gln Pro 
            580                 585                 590         


Glu Tyr Leu Ile Val Pro Glu Glu Val Met Gln Tyr Lys Val Lys Gln 
        595                 600                 605             


Lys Arg Ala Ala Ile His Ile Met Leu Ala Leu Ala Thr Val Leu Ser 
    610                 615                 620                 


Met Ala Gly Ala Gly Thr Gly Ala Thr Ala Ile Gly Met Val Thr Gln 
625                 630                 635                 640 


Tyr His Gln Val Leu Ala Thr His Gln Gln Ala Leu Asp Lys Ile Thr 
                645                 650                 655     


Glu Ala Leu Lys Ile Asn Asn Leu Arg Leu Ile Thr Leu Glu His Gln 
            660                 665                 670         


Val Leu Val Ile Gly Leu Lys Val Glu Ala Ile Glu Lys Arg Leu Tyr 
        675                 680                 685             


Thr Ala Phe Ala Met Gln Glu Leu Gly Cys Asn Gln Asn Gln Phe Phe 
    690                 695                 700                 


Cys Lys Ile Pro Pro Ser Leu Trp Ser Met Tyr Asn Met Thr Leu Asn 
705                 710                 715                 720 


Gln Thr Ile Trp Asn His Gly Asn Ile Ser Leu Gly Asn Trp Tyr Asn 
                725                 730                 735     


Gln Thr Arg Asp Leu Gln Asn Lys Phe Tyr Glu Ile Ile Met Asp Ile 
            740                 745                 750         


Glu Gln Asn Asn Val Gln Gly Lys Thr Gly Ile Gln Gln Leu Gln Lys 
        755                 760                 765             


Trp Glu Asn Trp Met Gly Trp Ile Gly Lys Ile Pro Gln Tyr Leu Lys 
    770                 775                 780                 


Gly Leu Leu Gly Ser Val Leu Gly Ile Gly Leu Gly Ile Leu Leu Leu 
785                 790                 795                 800 


Leu Ile Cys Leu Pro Thr Leu Val Asp Cys Ile Arg Asn Cys Thr Asn 
                805                 810                 815     


Lys Ile Leu Gly Tyr Thr Val Ile Ala Met Pro Glu Ile Asp Asp Glu 
            820                 825                 830         


Glu Val His Leu Ser Val Glu Leu Arg Arg Asn Gly Arg Gln Cys Gly 
        835                 840                 845             


Ile Ser Glu Lys Glu Glu Glu 
    850                 855 


<210>  407
<211>  855
<212>  PRT
<213>  Artificial sequence

<220>
<223>  Mutated sequence

<400>  407

Met Ala Glu Gly Gly Phe Thr Gln Asn Gln Gln Trp Ile Gly Pro Glu 
1               5                   10                  15      


Glu Ala Glu Glu Leu Leu Asp Phe Asp Ile Ala Val Gln Met Asn Glu 
            20                  25                  30          


Glu Gly Pro Leu Asn Pro Gly Val Asn Pro Phe Arg Val Pro Gly Ile 
        35                  40                  45              


Thr Ser Gln Glu Lys Glu Asp Tyr Cys Lys Ile Leu Gln Thr Lys Leu 
    50                  55                  60                  


Gln Glu Leu Lys Asn Glu Val Lys Gly Val Lys Ile Glu Glu Gly Asn 
65                  70                  75                  80  


Ala Gly Lys Phe Arg Arg Ala Arg Tyr Leu Arg Tyr Ser Asp Glu Asn 
                85                  90                  95      


Val Leu Ser Ile Val Tyr Leu Leu Ile Gly Tyr Leu Arg Tyr Leu Ile 
            100                 105                 110         


Asp His Arg Ser Leu Gly Ser Leu Arg His Asp Ile Asp Ile Glu Thr 
        115                 120                 125             


Pro Gln Glu Glu His Phe Asn Asn Ser Glu Lys Gly Thr Thr Leu Asn 
    130                 135                 140                 


Thr Lys Tyr Gly Arg Arg Cys Cys Leu Ser Thr Phe Ile Met Asn Leu 
145                 150                 155                 160 


Ile Leu Phe Ala Gly Val Gly Ile Trp Leu Gly Ala Arg Ala Gln Val 
                165                 170                 175     


Val Trp Arg Leu Pro Pro Leu Val Val Pro Val Asp Asp Thr Glu Ile 
            180                 185                 190         


Ile Phe Trp Asp Cys Trp Ala Pro Glu Glu Pro Ala Cys Gln Asp Phe 
        195                 200                 205             


Leu Gly Thr Met Val Gln Leu Lys Ala Ser Ile Asn Ile Ser Ile Gln 
    210                 215                 220                 


Glu Gly Pro Thr Leu Gly His Trp Ala Arg Glu Ile Leu Glu Thr Leu 
225                 230                 235                 240 


Phe Lys Lys Ala Thr Arg Gln Cys Arg Arg Gly Arg Val Trp Arg Arg 
                245                 250                 255     


Trp Asn Glu Thr Ile Thr Gly Pro Leu Gly Cys Ala Asn Asn Ala Cys 
            260                 265                 270         


Tyr Asn Ile Ser Val Val Val Pro Asp Tyr Gln Cys Tyr Val Asp Arg 
        275                 280                 285             


Val Asp Thr Trp Leu Gln Gly Arg Ile Asn Ile Ser Leu Cys Leu Thr 
    290                 295                 300                 


Gly Gly Lys Met Leu Tyr Asn Lys Asp Thr Gln Gln Leu Ser Tyr Cys 
305                 310                 315                 320 


Thr Glu Pro Leu Gln Ile Pro Leu Ile Asn Tyr Thr Phe Gly Pro Asn 
                325                 330                 335     


Gln Thr Cys Met Trp Asn Thr Ser Leu Ile Glu Asp Ser Glu Ile Pro 
            340                 345                 350         


Lys Cys Gly Trp Trp Asn Gln Ala Ala Tyr Tyr Asn Ser Cys Lys Trp 
        355                 360                 365             


Glu Gln Thr Asp Val Lys Phe Gln Cys Gln Arg Thr Gln Ser Gln Pro 
    370                 375                 380                 


Gly Thr Trp Leu Arg Ala Ile Ala Ser Trp Glu Gln Ala Asn Arg Trp 
385                 390                 395                 400 


Ile Trp Arg Pro Asp Phe Glu Ser Asp Lys Val Lys Ile Ser Leu Gln 
                405                 410                 415     


Cys Asn Ser Thr Lys Asn Leu Thr Phe Ala Met Arg Ser Ser Ser Asp 
            420                 425                 430         


Tyr Tyr Asp Val Gln Gly Ala Trp Ile Glu Phe Gly Cys His Arg Asn 
        435                 440                 445             


Lys Ser Arg Arg His Ser Glu Ala Arg Phe Arg Ile Arg Cys Lys Trp 
    450                 455                 460                 


Asn Glu Gly Lys Asn Ile Ser Leu Ile Asp Thr Cys Gly Thr Asn Pro 
465                 470                 475                 480 


Asn Val Thr Gly Ala Asn Pro Val Asp Cys Thr Met Lys Ala Asn Thr 
                485                 490                 495     


Met Tyr Asn Cys Ser Leu Gln Asp Ser Phe Thr Met Lys Ile Glu Asp 
            500                 505                 510         


Leu Ile Val His Phe Asn Met Thr Lys Ala Val Glu Met Tyr Asn Ile 
        515                 520                 525             


Ala Gly Asn Trp Ser Cys Thr Ser Asp Leu Pro Lys Gly Trp Gly Tyr 
    530                 535                 540                 


Met Asn Cys Asn Cys Thr Asn Gly Thr Asp Asp Ser Lys Thr Lys Met 
545                 550                 555                 560 


Ala Cys Pro Glu Asn Gln Gly Ile Leu Arg Asn Trp Tyr Asn Pro Val 
                565                 570                 575     


Ala Gly Leu Arg Gln Ala Leu Ile Lys Tyr His Val Val Lys Gln Pro 
            580                 585                 590         


Glu Tyr Leu Ile Val Pro Glu Glu Val Met Gln Tyr Lys Val Lys Gln 
        595                 600                 605             


Lys Arg Ala Ala Ile His Ile Met Leu Ala Leu Ala Thr Val Leu Ser 
    610                 615                 620                 


Met Ala Gly Ala Gly Thr Gly Ala Thr Ala Ile Gly Met Val Thr Gln 
625                 630                 635                 640 


Tyr His Gln Val Leu Ala Thr His Gln Gln Ala Leu Asp Lys Ile Thr 
                645                 650                 655     


Glu Ala Leu Lys Ile Asn Asn Leu Arg Leu Ile Thr Leu Glu His Gln 
            660                 665                 670         


Val Leu Val Ile Gly Leu Lys Val Glu Ala Ile Glu Lys Phe Arg Tyr 
        675                 680                 685             


Thr Ala Phe Ala Met Gln Glu Leu Gly Cys Asn Gln Asn Gln Phe Phe 
    690                 695                 700                 


Cys Lys Ile Pro Pro Ser Leu Trp Ser Met Tyr Asn Met Thr Leu Asn 
705                 710                 715                 720 


Gln Thr Ile Trp Asn His Gly Asn Ile Ser Leu Gly Asn Trp Tyr Asn 
                725                 730                 735     


Gln Thr Arg Asp Leu Gln Asn Lys Phe Tyr Glu Ile Ile Met Asp Ile 
            740                 745                 750         


Glu Gln Asn Asn Val Gln Gly Lys Thr Gly Ile Gln Gln Leu Gln Lys 
        755                 760                 765             


Trp Glu Asn Trp Met Gly Trp Ile Gly Lys Ile Pro Gln Tyr Leu Lys 
    770                 775                 780                 


Gly Leu Leu Gly Ser Val Leu Gly Ile Gly Leu Gly Ile Leu Leu Leu 
785                 790                 795                 800 


Leu Ile Cys Leu Pro Thr Leu Val Asp Cys Ile Arg Asn Cys Thr Asn 
                805                 810                 815     


Lys Ile Leu Gly Tyr Thr Val Ile Ala Met Pro Glu Ile Asp Asp Glu 
            820                 825                 830         


Glu Val His Leu Ser Val Glu Leu Arg Arg Asn Gly Arg Gln Cys Gly 
        835                 840                 845             


Ile Ser Glu Lys Glu Glu Glu 
    850                 855 


<210>  408
<211>  855
<212>  PRT
<213>  Artificial sequence

<220>
<223>  Mutated sequence

<400>  408

Met Ala Glu Gly Gly Phe Thr Gln Asn Gln Gln Trp Ile Gly Pro Glu 
1               5                   10                  15      


Glu Ala Glu Glu Leu Leu Asp Phe Asp Ile Ala Val Gln Met Asn Glu 
            20                  25                  30          


Glu Gly Pro Leu Asn Pro Gly Val Asn Pro Phe Arg Val Pro Gly Ile 
        35                  40                  45              


Thr Ser Gln Glu Lys Glu Asp Tyr Cys Lys Thr Leu Gln Thr Asn Leu 
    50                  55                  60                  


Gln Glu Leu Lys Asn Glu Val Lys Glu Val Lys Ile Glu Glu Gly Asn 
65                  70                  75                  80  


Ala Gly Lys Phe Arg Arg Ala Arg Phe Leu Arg Tyr Ser Asp Glu Asn 
                85                  90                  95      


Val Leu Ser Ile Val Tyr Leu Leu Ile Gly Tyr Leu Arg Tyr Leu Ile 
            100                 105                 110         


Asp His Arg Ser Leu Gly Ser Leu Arg His Asp Ile Asp Ile Glu Ala 
        115                 120                 125             


Pro Gln Glu Glu His Tyr Asn Asn Ser Glu Lys Gly Thr Thr Leu Asn 
    130                 135                 140                 


Ile Lys Tyr Ala Arg Arg Cys Cys Ile Ser Thr Phe Ile Met Tyr Leu 
145                 150                 155                 160 


Ile Leu Phe Ala Gly Val Gly Ile Trp Leu Gly Ala Arg Ala Gln Val 
                165                 170                 175     


Val Trp Arg Leu Pro Pro Leu Val Val Pro Val Asp Asp Thr Glu Ile 
            180                 185                 190         


Ile Phe Trp Asp Cys Trp Ala Pro Glu Glu Pro Ala Cys Gln Asp Phe 
        195                 200                 205             


Leu Gly Thr Met Val Gln Leu Lys Ala Ser Ile Asn Ile Gly Ile Gln 
    210                 215                 220                 


Glu Gly Pro Thr Leu Gly His Trp Ala Arg Glu Ile Trp Ser Thr Leu 
225                 230                 235                 240 


Phe Lys Lys Ala Thr Arg Gln Cys Arg Arg Gly Arg Val Trp Arg Arg 
                245                 250                 255     


Trp Asn Glu Thr Ile Thr Gly Pro Leu Gly Cys Ala Asn Asn Thr Cys 
            260                 265                 270         


Tyr Asn Ile Ser Val Val Val Pro Asp Tyr Gln Cys Tyr Val Asp Arg 
        275                 280                 285             


Val Asp Thr Trp Leu Gln Gly Arg Ile Asn Ile Ser Leu Cys Leu Thr 
    290                 295                 300                 


Gly Gly Lys Met Leu Tyr Asn Lys Asp Thr His Gln Leu Ser Tyr Cys 
305                 310                 315                 320 


Thr Glu Pro Leu Gln Ile Pro Leu Ile Asn Cys Thr Phe Gly Pro Ile 
                325                 330                 335     


Gln Thr Cys Met Trp Asn Thr Ser Leu Ile Gln Asp Pro Glu Ile Pro 
            340                 345                 350         


Lys Cys Gly Trp Trp Thr Gln Val Ala Tyr Tyr Asn Asn Cys Lys Trp 
        355                 360                 365             


Glu Glu Ala Asn Val Thr Phe Gln Cys His Arg Thr Gln Ser Arg Ser 
    370                 375                 380                 


Gly Ser Trp Leu Arg Thr Ile Ser Ser Trp Arg Gln Arg Asn Arg Trp 
385                 390                 395                 400 


Glu Trp Arg Pro Asp Phe Glu Ser Glu Lys Val Lys Ile Ser Leu Gln 
                405                 410                 415     


Cys Asn Ser Thr Lys Asn Leu Thr Phe Ala Met Arg Ser Ser Ser Asp 
            420                 425                 430         


Tyr Tyr Asp Val Gln Gly Ala Trp Ile Glu Phe Gly Cys His Arg Asn 
        435                 440                 445             


Lys Ser Lys Lys His Ser Glu Ala Arg Phe Arg Ile Arg Cys Lys Trp 
    450                 455                 460                 


Asn Glu Gly Asn Asn Ile Ser Leu Ile Asp Thr Cys Gly Thr Asn Pro 
465                 470                 475                 480 


Asn Val Thr Gly Ala Asn Pro Val Asp Cys Thr Met Lys Ala Asn Thr 
                485                 490                 495     


Met Tyr Asn Cys Ser Leu Gln Asp Ser Phe Thr Met Lys Ile Glu Asp 
            500                 505                 510         


Leu Ile Val His Phe Asn Met Thr Lys Ala Val Glu Met Tyr Asn Ile 
        515                 520                 525             


Ala Gly Asn Trp Ser Cys Thr Ser Asp Leu Pro Lys Gly Trp Gly Tyr 
    530                 535                 540                 


Met Asn Cys Asn Cys Thr Asn Gly Thr Asp Asp Ser Lys Thr Lys Met 
545                 550                 555                 560 


Ala Cys Pro Glu Asn Gln Gly Ile Leu Arg Asn Trp Tyr Asn Pro Val 
                565                 570                 575     


Ala Gly Leu Arg Gln Ala Leu Ile Lys Tyr Gln Val Val Lys Gln Pro 
            580                 585                 590         


Glu Tyr Leu Ile Val Pro Glu Glu Val Met Gln Tyr Lys Val Lys Gln 
        595                 600                 605             


Lys Arg Ala Ala Ile His Ile Met Leu Ala Leu Ala Thr Val Leu Ser 
    610                 615                 620                 


Met Ala Gly Ala Gly Thr Gly Ala Thr Ala Ile Gly Met Val Thr Gln 
625                 630                 635                 640 


Tyr His Gln Val Leu Ala Thr His Gln Gln Ala Leu Asp Lys Ile Thr 
                645                 650                 655     


Glu Ala Leu Lys Ile Asn Asn Leu Arg Leu Ile Thr Leu Glu His Gln 
            660                 665                 670         


Val Leu Val Ile Gly Leu Lys Val Glu Ala Ile Glu Lys Arg Leu Tyr 
        675                 680                 685             


Thr Ala Phe Ala Met Gln Glu Leu Gly Cys Asn Gln Asn Gln Phe Phe 
    690                 695                 700                 


Cys Lys Ile Pro Pro Ser Leu Trp Ser Met Tyr Asn Met Thr Leu Asn 
705                 710                 715                 720 


Gln Thr Ile Trp Asn His Gly Asn Ile Ser Leu Gly Asn Trp Tyr Asn 
                725                 730                 735     


Gln Thr Arg Asp Leu Gln Asn Lys Phe Tyr Glu Ile Ile Met Asp Ile 
            740                 745                 750         


Glu Gln Asn Asn Val Gln Gly Lys Thr Gly Ile Gln Gln Leu Gln Lys 
        755                 760                 765             


Trp Glu Asn Trp Val Gly Trp Ile Gly Lys Ile Pro Gln Tyr Leu Lys 
    770                 775                 780                 


Gly Leu Leu Gly Ser Val Leu Gly Ile Gly Leu Gly Ile Leu Leu Leu 
785                 790                 795                 800 


Leu Ile Cys Leu Pro Thr Leu Val Asp Cys Ile Arg Asn Cys Thr Asn 
                805                 810                 815     


Lys Ile Leu Gly Tyr Thr Val Ile Ala Met Pro Glu Ile Asp Asp Glu 
            820                 825                 830         


Glu Val His Leu Ser Val Glu Leu Arg Arg Asn Gly Arg Gln Cys Gly 
        835                 840                 845             


Ile Ser Glu Lys Glu Glu Glu 
    850                 855 


<210>  409
<211>  855
<212>  PRT
<213>  Artificial sequence

<220>
<223>  Mutated sequence

<400>  409

Met Ala Glu Gly Gly Phe Thr Gln Asn Gln Gln Trp Ile Gly Pro Glu 
1               5                   10                  15      


Glu Ala Glu Glu Leu Leu Asp Phe Asp Ile Ala Val Gln Met Asn Glu 
            20                  25                  30          


Glu Gly Pro Leu Asn Pro Gly Val Asn Pro Phe Arg Val Pro Gly Ile 
        35                  40                  45              


Thr Ser Gln Glu Lys Glu Asp Tyr Cys Lys Thr Leu Gln Thr Asn Leu 
    50                  55                  60                  


Gln Glu Leu Lys Asn Glu Val Lys Glu Val Lys Ile Glu Glu Gly Asn 
65                  70                  75                  80  


Ala Gly Lys Phe Arg Arg Ala Arg Phe Leu Arg Tyr Ser Asp Glu Asn 
                85                  90                  95      


Val Leu Ser Ile Val Tyr Leu Leu Ile Gly Tyr Leu Arg Tyr Leu Ile 
            100                 105                 110         


Asp His Arg Ser Leu Gly Ser Leu Arg His Asp Ile Asp Ile Glu Ala 
        115                 120                 125             


Pro Gln Glu Glu His Tyr Asn Asn Ser Glu Lys Gly Thr Thr Leu Asn 
    130                 135                 140                 


Ile Lys Tyr Ala Arg Arg Cys Cys Ile Ser Thr Phe Ile Met Tyr Leu 
145                 150                 155                 160 


Ile Leu Phe Ala Gly Val Gly Ile Trp Leu Gly Ala Arg Ala Gln Val 
                165                 170                 175     


Val Trp Arg Leu Pro Pro Leu Val Val Pro Val Asp Asp Thr Glu Ile 
            180                 185                 190         


Ile Phe Trp Asp Cys Trp Ala Pro Glu Glu Pro Ala Cys Gln Asp Phe 
        195                 200                 205             


Leu Gly Thr Met Val Gln Leu Lys Ala Ser Ile Asn Ile Gly Ile Gln 
    210                 215                 220                 


Glu Gly Pro Thr Leu Gly His Trp Ala Arg Glu Ile Trp Ser Thr Leu 
225                 230                 235                 240 


Phe Lys Lys Ala Thr Arg Gln Cys Arg Arg Gly Arg Val Trp Arg Arg 
                245                 250                 255     


Trp Asn Glu Thr Ile Thr Gly Pro Leu Gly Cys Ala Asn Asn Thr Cys 
            260                 265                 270         


Tyr Asn Ile Ser Val Val Val Pro Asp Tyr Gln Cys Tyr Val Asp Arg 
        275                 280                 285             


Val Asp Thr Trp Leu Gln Gly Arg Ile Asn Ile Ser Leu Cys Leu Thr 
    290                 295                 300                 


Gly Gly Lys Met Leu Tyr Asn Lys Asp Thr His Gln Leu Ser Tyr Cys 
305                 310                 315                 320 


Thr Glu Pro Leu Gln Ile Pro Leu Ile Asn Cys Thr Phe Gly Pro Ile 
                325                 330                 335     


Gln Thr Cys Met Trp Asn Thr Ser Leu Ile Gln Asp Pro Glu Ile Pro 
            340                 345                 350         


Lys Cys Gly Trp Trp Thr Gln Val Ala Tyr Tyr Asn Asn Cys Lys Trp 
        355                 360                 365             


Glu Glu Ala Asn Val Thr Phe Gln Cys His Arg Thr Gln Ser Arg Ser 
    370                 375                 380                 


Gly Ser Trp Leu Arg Thr Ile Ser Ser Trp Arg Gln Arg Asn Arg Trp 
385                 390                 395                 400 


Glu Trp Arg Pro Asp Phe Glu Ser Glu Lys Val Lys Ile Ser Leu Gln 
                405                 410                 415     


Cys Asn Ser Thr Lys Asn Leu Thr Phe Ala Met Arg Ser Ser Ser Asp 
            420                 425                 430         


Tyr Tyr Asp Val Gln Gly Ala Trp Ile Glu Phe Gly Cys His Arg Asn 
        435                 440                 445             


Lys Ser Lys Lys His Ser Glu Ala Arg Phe Arg Ile Arg Cys Lys Trp 
    450                 455                 460                 


Asn Glu Gly Asn Asn Ile Ser Leu Ile Asp Thr Cys Gly Thr Asn Pro 
465                 470                 475                 480 


Asn Val Thr Gly Ala Asn Pro Val Asp Cys Thr Met Lys Ala Asn Thr 
                485                 490                 495     


Met Tyr Asn Cys Ser Leu Gln Asp Ser Phe Thr Met Lys Ile Glu Asp 
            500                 505                 510         


Leu Ile Val His Phe Asn Met Thr Lys Ala Val Glu Met Tyr Asn Ile 
        515                 520                 525             


Ala Gly Asn Trp Ser Cys Thr Ser Asp Leu Pro Lys Gly Trp Gly Tyr 
    530                 535                 540                 


Met Asn Cys Asn Cys Thr Asn Gly Thr Asp Asp Ser Lys Thr Lys Met 
545                 550                 555                 560 


Ala Cys Pro Glu Asn Gln Gly Ile Leu Arg Asn Trp Tyr Asn Pro Val 
                565                 570                 575     


Ala Gly Leu Arg Gln Ala Leu Ile Lys Tyr Gln Val Val Lys Gln Pro 
            580                 585                 590         


Glu Tyr Leu Ile Val Pro Glu Glu Val Met Gln Tyr Lys Val Lys Gln 
        595                 600                 605             


Lys Arg Ala Ala Ile His Ile Met Leu Ala Leu Ala Thr Val Leu Ser 
    610                 615                 620                 


Met Ala Gly Ala Gly Thr Gly Ala Thr Ala Ile Gly Met Val Thr Gln 
625                 630                 635                 640 


Tyr His Gln Val Leu Ala Thr His Gln Gln Ala Leu Asp Lys Ile Thr 
                645                 650                 655     


Glu Ala Leu Lys Ile Asn Asn Leu Arg Leu Ile Thr Leu Glu His Gln 
            660                 665                 670         


Val Leu Val Ile Gly Leu Lys Val Glu Ala Ile Glu Lys Phe Arg Tyr 
        675                 680                 685             


Thr Ala Phe Ala Met Gln Glu Leu Gly Cys Asn Gln Asn Gln Phe Phe 
    690                 695                 700                 


Cys Lys Ile Pro Pro Ser Leu Trp Ser Met Tyr Asn Met Thr Leu Asn 
705                 710                 715                 720 


Gln Thr Ile Trp Asn His Gly Asn Ile Ser Leu Gly Asn Trp Tyr Asn 
                725                 730                 735     


Gln Thr Arg Asp Leu Gln Asn Lys Phe Tyr Glu Ile Ile Met Asp Ile 
            740                 745                 750         


Glu Gln Asn Asn Val Gln Gly Lys Thr Gly Ile Gln Gln Leu Gln Lys 
        755                 760                 765             


Trp Glu Asn Trp Val Gly Trp Ile Gly Lys Ile Pro Gln Tyr Leu Lys 
    770                 775                 780                 


Gly Leu Leu Gly Ser Val Leu Gly Ile Gly Leu Gly Ile Leu Leu Leu 
785                 790                 795                 800 


Leu Ile Cys Leu Pro Thr Leu Val Asp Cys Ile Arg Asn Cys Thr Asn 
                805                 810                 815     


Lys Ile Leu Gly Tyr Thr Val Ile Ala Met Pro Glu Ile Asp Asp Glu 
            820                 825                 830         


Glu Val His Leu Ser Val Glu Leu Arg Arg Asn Gly Arg Gln Cys Gly 
        835                 840                 845             


Ile Ser Glu Lys Glu Glu Glu 
    850                 855 


<210>  410
<211>  855
<212>  PRT
<213>  Artificial sequence

<220>
<223>  Mutated sequence

<400>  410

Met Ala Glu Gly Gly Phe Thr His Asn Gln Gln Trp Ile Gly Pro Glu 
1               5                   10                  15      


Glu Ala Glu Glu Leu Leu Asp Phe Asp Ile Ala Val Gln Met Asn Glu 
            20                  25                  30          


Glu Gly Pro Leu Asn Pro Gly Val Asn Pro Phe Arg Val Pro Gly Ile 
        35                  40                  45              


Thr Ser Gln Glu Lys Asp Asp Tyr Cys Lys Ile Leu Gln Thr Lys Leu 
    50                  55                  60                  


Gln Glu Leu Lys Asn Glu Val Lys Glu Val Lys Ile Glu Glu Gly Asn 
65                  70                  75                  80  


Ala Gly Lys Phe Arg Arg Ala Arg Tyr Leu Arg Tyr Ser Asp Glu Asn 
                85                  90                  95      


Val Leu Ser Ile Val Tyr Leu Leu Ile Gly Tyr Leu Arg Tyr Leu Ile 
            100                 105                 110         


Asp His Arg Ser Leu Gly Ser Leu Arg His Asp Ile Asp Ile Glu Thr 
        115                 120                 125             


Pro Gln Glu Glu His Tyr Asn Asn Ser Glu Lys Gly Thr Thr Leu Asn 
    130                 135                 140                 


Ile Lys Tyr Gly Arg Arg Cys Cys Ile Ser Thr Phe Ile Met Tyr Leu 
145                 150                 155                 160 


Ile Leu Phe Ala Gly Val Gly Ile Trp Leu Gly Ala Arg Ala Gln Val 
                165                 170                 175     


Val Trp Arg Leu Pro Pro Leu Val Val Pro Val Asp Asp Thr Glu Ile 
            180                 185                 190         


Ile Phe Trp Asp Cys Trp Ala Pro Glu Glu Pro Ala Cys Gln Asp Phe 
        195                 200                 205             


Leu Gly Thr Met Ile Tyr Leu Lys Ala Asn Val Asn Ile Ser Ile Gln 
    210                 215                 220                 


Glu Gly Pro Thr Leu Gly Asn Trp Ala Arg Glu Ile Trp Ser Thr Leu 
225                 230                 235                 240 


Phe Lys Lys Ala Thr Arg Gln Cys Arg Arg Gly Arg Ile Trp Arg Arg 
                245                 250                 255     


Trp Asn Glu Thr Ile Thr Gly Pro Leu Gly Cys Ala Asn Asn Thr Cys 
            260                 265                 270         


Tyr Asn Ile Ser Val Val Val Pro Asp Tyr Gln Cys Tyr Val Asp Arg 
        275                 280                 285             


Val Asp Thr Trp Leu Gln Gly Lys Val Asn Ile Ser Leu Cys Leu Thr 
    290                 295                 300                 


Gly Gly Lys Met Leu Tyr Asn Lys Glu Thr Arg Gln Leu Ser Tyr Cys 
305                 310                 315                 320 


Thr Asp Pro Leu Gln Ile Pro Leu Ile Asn Tyr Thr Phe Gly Pro Asn 
                325                 330                 335     


Gln Thr Cys Met Trp Asn Thr Ser Leu Ile Lys Asp Ser Glu Ile Pro 
            340                 345                 350         


Lys Cys Gly Trp Trp Asn Gln Val Ala Tyr Tyr Asp Thr Cys Lys Trp 
        355                 360                 365             


Glu Glu Ala Asn Val Thr Phe Gln Cys His Arg Thr Gln Ser Gln Ser 
    370                 375                 380                 


Gly Ser Trp Ile Arg Thr Ile Ser Ser Trp Lys Gln Arg Asn Arg Trp 
385                 390                 395                 400 


Glu Trp Arg Pro Asp Phe Glu Ser Glu Lys Val Lys Ile Ser Leu Gln 
                405                 410                 415     


Cys Asn Ser Thr Lys Asn Leu Thr Phe Ala Met Arg Ser Ser Ser Asp 
            420                 425                 430         


Tyr Tyr Asp Val Gln Gly Ala Trp Ile Glu Phe Gly Cys His Arg Asn 
        435                 440                 445             


Lys Ser Lys Arg His Ser Glu Ala Arg Phe Arg Ile Arg Cys Lys Trp 
    450                 455                 460                 


Asn Glu Gly Asn Asn Ile Ser Leu Ile Asp Thr Cys Gly Thr Asn Pro 
465                 470                 475                 480 


Asn Val Thr Gly Ala Asn Pro Val Asp Cys Thr Met Lys Ala Asn Thr 
                485                 490                 495     


Met Tyr Asn Cys Ser Leu Gln Asp Ser Phe Thr Met Lys Ile Glu Asp 
            500                 505                 510         


Leu Ile Val His Phe Asn Met Thr Lys Ala Val Glu Leu Tyr Asn Ile 
        515                 520                 525             


Ala Gly Asn Trp Ser Cys Thr Ser Asp Leu Pro Lys Gly Trp Gly Tyr 
    530                 535                 540                 


Met Asn Cys Asn Cys Thr Asn Gly Thr Asp Asn Ser Glu Thr Lys Met 
545                 550                 555                 560 


Ala Cys Pro Lys Asn Gln Gly Ile Leu Arg Asn Trp Tyr Asn Pro Val 
                565                 570                 575     


Ala Gly Leu Arg Gln Ala Leu Ile Lys Tyr Gln Val Val Lys Gln Pro 
            580                 585                 590         


Glu Tyr Leu Ile Val Pro Glu Glu Val Met Gln Tyr Lys Phe Lys Gln 
        595                 600                 605             


Lys Arg Ala Ala Ile His Ile Met Leu Ala Leu Ala Thr Val Leu Ser 
    610                 615                 620                 


Met Ala Gly Ala Gly Thr Gly Ala Thr Ala Ile Gly Met Val Thr Gln 
625                 630                 635                 640 


Tyr His Gln Val Leu Ala Thr His Gln Gln Ala Leu Glu Lys Ile Thr 
                645                 650                 655     


Glu Ala Leu Lys Ile Asn Asn Leu Arg Leu Ile Thr Leu Glu His Gln 
            660                 665                 670         


Val Leu Val Ile Gly Leu Arg Val Glu Ala Ile Glu Lys Arg Leu Tyr 
        675                 680                 685             


Thr Ala Phe Ala Met Gln Glu Leu Gly Cys Asn Gln Asn Gln Phe Phe 
    690                 695                 700                 


Cys Lys Ile Pro Pro Ser Leu Trp Ser Met Tyr Asn Met Thr Leu Asn 
705                 710                 715                 720 


Gln Thr Ile Trp Asn His Gly Asn Ile Ser Leu Gly Asn Trp Tyr Asn 
                725                 730                 735     


Gln Thr Arg Asp Leu Gln Asn Lys Phe Tyr Glu Ile Ile Met Asp Ile 
            740                 745                 750         


Glu Gln Asn Asn Val Gln Gly Lys Thr Gly Ile Gln Gln Leu Gln Lys 
        755                 760                 765             


Trp Glu Asn Trp Val Gly Trp Ile Gly Lys Ile Pro Gln Tyr Leu Lys 
    770                 775                 780                 


Gly Leu Leu Gly Ser Val Leu Gly Ile Gly Leu Gly Ile Leu Leu Leu 
785                 790                 795                 800 


Leu Ile Cys Leu Pro Thr Leu Val Asp Cys Ile Arg Asn Cys Thr Asn 
                805                 810                 815     


Lys Ile Leu Gly Tyr Thr Val Ile Ala Met Pro Glu Ile Asp Asp Glu 
            820                 825                 830         


Glu Val His Leu Ser Val Glu Leu Arg Arg Asn Gly Arg Gln Cys Gly 
        835                 840                 845             


Ile Ser Glu Lys Glu Glu Glu 
    850                 855 


<210>  411
<211>  855
<212>  PRT
<213>  Artificial sequence

<220>
<223>  Mutated sequence

<400>  411

Met Ala Glu Gly Gly Phe Thr His Asn Gln Gln Trp Ile Gly Pro Glu 
1               5                   10                  15      


Glu Ala Glu Glu Leu Leu Asp Phe Asp Ile Ala Val Gln Met Asn Glu 
            20                  25                  30          


Glu Gly Pro Leu Asn Pro Gly Val Asn Pro Phe Arg Val Pro Gly Ile 
        35                  40                  45              


Thr Ser Gln Glu Lys Asp Asp Tyr Cys Lys Ile Leu Gln Thr Lys Leu 
    50                  55                  60                  


Gln Glu Leu Lys Asn Glu Val Lys Glu Val Lys Ile Glu Glu Gly Asn 
65                  70                  75                  80  


Ala Gly Lys Phe Arg Arg Ala Arg Tyr Leu Arg Tyr Ser Asp Glu Asn 
                85                  90                  95      


Val Leu Ser Ile Val Tyr Leu Leu Ile Gly Tyr Leu Arg Tyr Leu Ile 
            100                 105                 110         


Asp His Arg Ser Leu Gly Ser Leu Arg His Asp Ile Asp Ile Glu Thr 
        115                 120                 125             


Pro Gln Glu Glu His Tyr Asn Asn Ser Glu Lys Gly Thr Thr Leu Asn 
    130                 135                 140                 


Ile Lys Tyr Gly Arg Arg Cys Cys Ile Ser Thr Phe Ile Met Tyr Leu 
145                 150                 155                 160 


Ile Leu Phe Ala Gly Val Gly Ile Trp Leu Gly Ala Arg Ala Gln Val 
                165                 170                 175     


Val Trp Arg Leu Pro Pro Leu Val Val Pro Val Asp Asp Thr Glu Ile 
            180                 185                 190         


Ile Phe Trp Asp Cys Trp Ala Pro Glu Glu Pro Ala Cys Gln Asp Phe 
        195                 200                 205             


Leu Gly Thr Met Ile Tyr Leu Lys Ala Asn Val Asn Ile Ser Ile Gln 
    210                 215                 220                 


Glu Gly Pro Thr Leu Gly Asn Trp Ala Arg Glu Ile Trp Ser Thr Leu 
225                 230                 235                 240 


Phe Lys Lys Ala Thr Arg Gln Cys Arg Arg Gly Arg Ile Trp Arg Arg 
                245                 250                 255     


Trp Asn Glu Thr Ile Thr Gly Pro Leu Gly Cys Ala Asn Asn Thr Cys 
            260                 265                 270         


Tyr Asn Ile Ser Val Val Val Pro Asp Tyr Gln Cys Tyr Val Asp Arg 
        275                 280                 285             


Val Asp Thr Trp Leu Gln Gly Lys Val Asn Ile Ser Leu Cys Leu Thr 
    290                 295                 300                 


Gly Gly Lys Met Leu Tyr Asn Lys Glu Thr Arg Gln Leu Ser Tyr Cys 
305                 310                 315                 320 


Thr Asp Pro Leu Gln Ile Pro Leu Ile Asn Tyr Thr Phe Gly Pro Asn 
                325                 330                 335     


Gln Thr Cys Met Trp Asn Thr Ser Leu Ile Lys Asp Ser Glu Ile Pro 
            340                 345                 350         


Lys Cys Gly Trp Trp Asn Gln Val Ala Tyr Tyr Asp Thr Cys Lys Trp 
        355                 360                 365             


Glu Glu Ala Asn Val Thr Phe Gln Cys His Arg Thr Gln Ser Gln Ser 
    370                 375                 380                 


Gly Ser Trp Ile Arg Thr Ile Ser Ser Trp Lys Gln Arg Asn Arg Trp 
385                 390                 395                 400 


Glu Trp Arg Pro Asp Phe Glu Ser Glu Lys Val Lys Ile Ser Leu Gln 
                405                 410                 415     


Cys Asn Ser Thr Lys Asn Leu Thr Phe Ala Met Arg Ser Ser Ser Asp 
            420                 425                 430         


Tyr Tyr Asp Val Gln Gly Ala Trp Ile Glu Phe Gly Cys His Arg Asn 
        435                 440                 445             


Lys Ser Lys Arg His Ser Glu Ala Arg Phe Arg Ile Arg Cys Lys Trp 
    450                 455                 460                 


Asn Glu Gly Asn Asn Ile Ser Leu Ile Asp Thr Cys Gly Thr Asn Pro 
465                 470                 475                 480 


Asn Val Thr Gly Ala Asn Pro Val Asp Cys Thr Met Lys Ala Asn Thr 
                485                 490                 495     


Met Tyr Asn Cys Ser Leu Gln Asp Ser Phe Thr Met Lys Ile Glu Asp 
            500                 505                 510         


Leu Ile Val His Phe Asn Met Thr Lys Ala Val Glu Leu Tyr Asn Ile 
        515                 520                 525             


Ala Gly Asn Trp Ser Cys Thr Ser Asp Leu Pro Lys Gly Trp Gly Tyr 
    530                 535                 540                 


Met Asn Cys Asn Cys Thr Asn Gly Thr Asp Asn Ser Glu Thr Lys Met 
545                 550                 555                 560 


Ala Cys Pro Lys Asn Gln Gly Ile Leu Arg Asn Trp Tyr Asn Pro Val 
                565                 570                 575     


Ala Gly Leu Arg Gln Ala Leu Ile Lys Tyr Gln Val Val Lys Gln Pro 
            580                 585                 590         


Glu Tyr Leu Ile Val Pro Glu Glu Val Met Gln Tyr Lys Phe Lys Gln 
        595                 600                 605             


Lys Arg Ala Ala Ile His Ile Met Leu Ala Leu Ala Thr Val Leu Ser 
    610                 615                 620                 


Met Ala Gly Ala Gly Thr Gly Ala Thr Ala Ile Gly Met Val Thr Gln 
625                 630                 635                 640 


Tyr His Gln Val Leu Ala Thr His Gln Gln Ala Leu Glu Lys Ile Thr 
                645                 650                 655     


Glu Ala Leu Lys Ile Asn Asn Leu Arg Leu Ile Thr Leu Glu His Gln 
            660                 665                 670         


Val Leu Val Ile Gly Leu Arg Val Glu Ala Ile Glu Lys Phe Arg Tyr 
        675                 680                 685             


Thr Ala Phe Ala Met Gln Glu Leu Gly Cys Asn Gln Asn Gln Phe Phe 
    690                 695                 700                 


Cys Lys Ile Pro Pro Ser Leu Trp Ser Met Tyr Asn Met Thr Leu Asn 
705                 710                 715                 720 


Gln Thr Ile Trp Asn His Gly Asn Ile Ser Leu Gly Asn Trp Tyr Asn 
                725                 730                 735     


Gln Thr Arg Asp Leu Gln Asn Lys Phe Tyr Glu Ile Ile Met Asp Ile 
            740                 745                 750         


Glu Gln Asn Asn Val Gln Gly Lys Thr Gly Ile Gln Gln Leu Gln Lys 
        755                 760                 765             


Trp Glu Asn Trp Val Gly Trp Ile Gly Lys Ile Pro Gln Tyr Leu Lys 
    770                 775                 780                 


Gly Leu Leu Gly Ser Val Leu Gly Ile Gly Leu Gly Ile Leu Leu Leu 
785                 790                 795                 800 


Leu Ile Cys Leu Pro Thr Leu Val Asp Cys Ile Arg Asn Cys Thr Asn 
                805                 810                 815     


Lys Ile Leu Gly Tyr Thr Val Ile Ala Met Pro Glu Ile Asp Asp Glu 
            820                 825                 830         


Glu Val His Leu Ser Val Glu Leu Arg Arg Asn Gly Arg Gln Cys Gly 
        835                 840                 845             


Ile Ser Glu Lys Glu Glu Glu 
    850                 855 


<210>  412
<211>  853
<212>  PRT
<213>  Artificial sequence

<220>
<223>  Mutated sequence

<400>  412

Met Ala Glu Gly Gly Phe Thr Gln Asn Gln Gln Trp Ile Gly Pro Glu 
1               5                   10                  15      


Glu Ala Glu Glu Leu Leu Asp Phe Asp Ile Ala Val Gln Met Asn Glu 
            20                  25                  30          


Glu Gly Pro Leu His Pro Gly Ile Asn Pro Phe Arg Val Pro Gly Ile 
        35                  40                  45              


Thr Pro Gln Glu Lys Glu Asp Tyr Cys Lys Ile Leu Gln Pro Lys Leu 
    50                  55                  60                  


Gln Glu Leu Lys Gly Glu Ile Lys Glu Val Lys Leu Glu Glu Arg Asn 
65                  70                  75                  80  


Ala Gly Lys Phe Arg Arg Ala Arg Tyr Leu Arg Tyr Ser Asp Glu Asn 
                85                  90                  95      


Val Leu Ser Ile Ile Tyr Leu Leu Thr Gly Tyr Phe Arg Tyr Leu Ile 
            100                 105                 110         


Asn His Arg Ser Leu Gly Ala Leu Arg His Asp Ile Asp Ile Glu Ala 
        115                 120                 125             


Pro Gln Lys Glu Gln Tyr Ser Asn Asn Glu Lys Gly Thr Thr Leu Asn 
    130                 135                 140                 


Ile Lys Tyr Gly Arg Val Cys Cys Ile Ser Thr Leu Leu Leu Tyr Leu 
145                 150                 155                 160 


Leu Leu Phe Ala Gly Leu Gly Val Trp Tyr Gly Thr Ser Ala Gln Val 
                165                 170                 175     


Val Trp Arg Leu Pro Pro Leu Val Val Pro Val Glu Asp Thr Glu Ile 
            180                 185                 190         


Ile Phe Trp Asp Cys Trp Ala Pro Glu Glu Pro Ala Cys Gln Asp Phe 
        195                 200                 205             


Leu Gly Thr Met Ile His Leu Lys Ala Asn Val Asn Ile Ser Ile Gln 
    210                 215                 220                 


Glu Gly Pro Thr Leu Gly Asn Trp Ala Arg Glu Ile Trp Ser Thr Leu 
225                 230                 235                 240 


Phe Lys Lys Ala Thr Arg Gln Cys Arg Arg Gly Arg Ile Trp Arg Arg 
                245                 250                 255     


Trp Asn Glu Thr Ile Thr Gly Pro Leu Gly Cys Ala Asn Asn Thr Cys 
            260                 265                 270         


Tyr Asn Ile Ser Val Val Val Pro Asp Tyr Gln Cys Tyr Val Asp Arg 
        275                 280                 285             


Val Asp Thr Trp Leu Gln Gly Lys Val Asn Ile Ser Leu Cys Leu Thr 
    290                 295                 300                 


Gly Gly Lys Met Leu Tyr Asn Lys Glu Thr Arg Gln Leu Ser Tyr Cys 
305                 310                 315                 320 


Thr Asp Pro Leu Gln Ile Pro Leu Ile Asn Tyr Thr Phe Gly Pro Asn 
                325                 330                 335     


Gln Thr Cys Met Trp Asn Thr Ser Leu Ile Lys Asp Ser Glu Ile Pro 
            340                 345                 350         


Lys Cys Gly Trp Trp Asn Gln Val Ala Tyr Tyr Asn Ala Cys Lys Trp 
        355                 360                 365             


Glu Glu Ala Asn Val Thr Phe Gln Cys His Arg Thr Gln Ser Gln Pro 
    370                 375                 380                 


Gly Ser Trp Ile Arg Thr Ile Ser Ser Trp Lys Gln Arg Asn Arg Trp 
385                 390                 395                 400 


Glu Trp Arg Pro Asp Phe Glu Ser Glu Lys Val Lys Ile Ser Leu Gln 
                405                 410                 415     


Cys Asn Ser Thr Lys Asn Leu Thr Phe Ala Met Arg Ser Ser Ser Asp 
            420                 425                 430         


Tyr Tyr Asp Ile Gln Gly Ala Trp Ile Glu Phe Gly Tyr His Arg Asn 
        435                 440                 445             


Lys Ser Lys Met His Ser Glu Val Arg Phe Arg Ile Arg Cys Lys Trp 
    450                 455                 460                 


Asn Glu Gly Asn Asn Ile Ser Leu Ile Asp Thr Cys Gly Thr Asn Pro 
465                 470                 475                 480 


Asn Val Thr Gly Ala Asn Pro Val Asp Cys Thr Met Lys Ala Asn Thr 
                485                 490                 495     


Met Tyr Asn Cys Ser Leu Gln Asp Ser Phe Thr Met Lys Ile Glu Asp 
            500                 505                 510         


Leu Ile Val His Phe Asn Met Thr Lys Ala Val Glu Met Tyr Asn Ile 
        515                 520                 525             


Ala Gly Asn Trp Ser Cys Thr Ser Asp Leu Pro Lys Gly Trp Gly Tyr 
    530                 535                 540                 


Met Asn Cys Asn Cys Thr Asn Gly Thr Asp Glu Ser Gly Thr Lys Met 
545                 550                 555                 560 


Ala Cys Pro Lys Ser Gln Gly Ile Leu Arg Asn Trp Tyr Asn Pro Val 
                565                 570                 575     


Ala Gly Leu Arg Gln Ala Leu Ile Lys Tyr Gln Val Val Lys Gln Pro 
            580                 585                 590         


Glu Tyr Leu Ile Val Pro Glu Glu Val Met Gln Tyr Lys Phe Lys Gln 
        595                 600                 605             


Lys Arg Ala Ala Ile His Ile Met Leu Ala Leu Ala Thr Val Leu Ser 
    610                 615                 620                 


Met Ala Gly Ala Gly Thr Gly Ala Thr Ala Ile Gly Met Val Thr Gln 
625                 630                 635                 640 


Tyr His Gln Val Leu Ala Thr His Gln Gln Ala Leu Asp Lys Ile Thr 
                645                 650                 655     


Gln Ala Leu Lys Ile Asn Asn Leu Arg Leu Ile Thr Leu Glu His Gln 
            660                 665                 670         


Val Leu Val Ile Gly Leu Lys Val Glu Ala Ile Glu Lys Arg Leu Tyr 
        675                 680                 685             


Thr Ala Phe Ala Met Gln Glu Leu Gly Cys Asn Gln Asn Gln Phe Phe 
    690                 695                 700                 


Cys Lys Ile Pro Pro Ser Leu Trp Ser Met Tyr Asn Met Thr Leu Asn 
705                 710                 715                 720 


Gln Thr Ile Trp Asn His Gly Asn Ile Ser Leu Gly Asn Trp Tyr Asn 
                725                 730                 735     


Gln Thr Lys Asp Leu Gln Asn Lys Phe Tyr Glu Ile Ile Met Asp Ile 
            740                 745                 750         


Glu Gln Asn Asn Val Gln Gly Lys Thr Gly Ile Gln Gln Leu Gln Lys 
        755                 760                 765             


Trp Glu Asn Trp Val Gly Trp Ile Gly Lys Ile Pro Gln Tyr Leu Lys 
    770                 775                 780                 


Gly Leu Leu Gly Ser Val Leu Gly Ile Gly Val Gly Ile Leu Leu Leu 
785                 790                 795                 800 


Ile Ile Cys Leu Pro Thr Leu Val Asp Cys Val Arg Asn Cys Ile Asn 
                805                 810                 815     


Lys Val Leu Gly Tyr Ser Val Ile Ala Met Pro Glu Leu Asp Asp Glu 
            820                 825                 830         


Glu Val Ser Met Glu Leu Arg Arg Asn Gly Arg Gln Cys Gly Met Ser 
        835                 840                 845             


Glu Lys Glu Glu Glu 
    850             


<210>  413
<211>  853
<212>  PRT
<213>  Artificial sequence

<220>
<223>  Mutated sequence

<400>  413

Met Ala Glu Gly Gly Phe Thr Gln Asn Gln Gln Trp Ile Gly Pro Glu 
1               5                   10                  15      


Glu Ala Glu Glu Leu Leu Asp Phe Asp Ile Ala Val Gln Met Asn Glu 
            20                  25                  30          


Glu Gly Pro Leu His Pro Gly Ile Asn Pro Phe Arg Val Pro Gly Ile 
        35                  40                  45              


Thr Pro Gln Glu Lys Glu Asp Tyr Cys Lys Ile Leu Gln Pro Lys Leu 
    50                  55                  60                  


Gln Glu Leu Lys Gly Glu Ile Lys Glu Val Lys Leu Glu Glu Arg Asn 
65                  70                  75                  80  


Ala Gly Lys Phe Arg Arg Ala Arg Tyr Leu Arg Tyr Ser Asp Glu Asn 
                85                  90                  95      


Val Leu Ser Ile Ile Tyr Leu Leu Thr Gly Tyr Phe Arg Tyr Leu Ile 
            100                 105                 110         


Asn His Arg Ser Leu Gly Ala Leu Arg His Asp Ile Asp Ile Glu Ala 
        115                 120                 125             


Pro Gln Lys Glu Gln Tyr Ser Asn Asn Glu Lys Gly Thr Thr Leu Asn 
    130                 135                 140                 


Ile Lys Tyr Gly Arg Val Cys Cys Ile Ser Thr Leu Leu Leu Tyr Leu 
145                 150                 155                 160 


Leu Leu Phe Ala Gly Leu Gly Val Trp Tyr Gly Thr Ser Ala Gln Val 
                165                 170                 175     


Val Trp Arg Leu Pro Pro Leu Val Val Pro Val Glu Asp Thr Glu Ile 
            180                 185                 190         


Ile Phe Trp Asp Cys Trp Ala Pro Glu Glu Pro Ala Cys Gln Asp Phe 
        195                 200                 205             


Leu Gly Thr Met Ile His Leu Lys Ala Asn Val Asn Ile Ser Ile Gln 
    210                 215                 220                 


Glu Gly Pro Thr Leu Gly Asn Trp Ala Arg Glu Ile Trp Ser Thr Leu 
225                 230                 235                 240 


Phe Lys Lys Ala Thr Arg Gln Cys Arg Arg Gly Arg Ile Trp Arg Arg 
                245                 250                 255     


Trp Asn Glu Thr Ile Thr Gly Pro Leu Gly Cys Ala Asn Asn Thr Cys 
            260                 265                 270         


Tyr Asn Ile Ser Val Val Val Pro Asp Tyr Gln Cys Tyr Val Asp Arg 
        275                 280                 285             


Val Asp Thr Trp Leu Gln Gly Lys Val Asn Ile Ser Leu Cys Leu Thr 
    290                 295                 300                 


Gly Gly Lys Met Leu Tyr Asn Lys Glu Thr Arg Gln Leu Ser Tyr Cys 
305                 310                 315                 320 


Thr Asp Pro Leu Gln Ile Pro Leu Ile Asn Tyr Thr Phe Gly Pro Asn 
                325                 330                 335     


Gln Thr Cys Met Trp Asn Thr Ser Leu Ile Lys Asp Ser Glu Ile Pro 
            340                 345                 350         


Lys Cys Gly Trp Trp Asn Gln Val Ala Tyr Tyr Asn Ala Cys Lys Trp 
        355                 360                 365             


Glu Glu Ala Asn Val Thr Phe Gln Cys His Arg Thr Gln Ser Gln Pro 
    370                 375                 380                 


Gly Ser Trp Ile Arg Thr Ile Ser Ser Trp Lys Gln Arg Asn Arg Trp 
385                 390                 395                 400 


Glu Trp Arg Pro Asp Phe Glu Ser Glu Lys Val Lys Ile Ser Leu Gln 
                405                 410                 415     


Cys Asn Ser Thr Lys Asn Leu Thr Phe Ala Met Arg Ser Ser Ser Asp 
            420                 425                 430         


Tyr Tyr Asp Ile Gln Gly Ala Trp Ile Glu Phe Gly Tyr His Arg Asn 
        435                 440                 445             


Lys Ser Lys Met His Ser Glu Val Arg Phe Arg Ile Arg Cys Lys Trp 
    450                 455                 460                 


Asn Glu Gly Asn Asn Ile Ser Leu Ile Asp Thr Cys Gly Thr Asn Pro 
465                 470                 475                 480 


Asn Val Thr Gly Ala Asn Pro Val Asp Cys Thr Met Lys Ala Asn Thr 
                485                 490                 495     


Met Tyr Asn Cys Ser Leu Gln Asp Ser Phe Thr Met Lys Ile Glu Asp 
            500                 505                 510         


Leu Ile Val His Phe Asn Met Thr Lys Ala Val Glu Met Tyr Asn Ile 
        515                 520                 525             


Ala Gly Asn Trp Ser Cys Thr Ser Asp Leu Pro Lys Gly Trp Gly Tyr 
    530                 535                 540                 


Met Asn Cys Asn Cys Thr Asn Gly Thr Asp Glu Ser Gly Thr Lys Met 
545                 550                 555                 560 


Ala Cys Pro Lys Ser Gln Gly Ile Leu Arg Asn Trp Tyr Asn Pro Val 
                565                 570                 575     


Ala Gly Leu Arg Gln Ala Leu Ile Lys Tyr Gln Val Val Lys Gln Pro 
            580                 585                 590         


Glu Tyr Leu Ile Val Pro Glu Glu Val Met Gln Tyr Lys Phe Lys Gln 
        595                 600                 605             


Lys Arg Ala Ala Ile His Ile Met Leu Ala Leu Ala Thr Val Leu Ser 
    610                 615                 620                 


Met Ala Gly Ala Gly Thr Gly Ala Thr Ala Ile Gly Met Val Thr Gln 
625                 630                 635                 640 


Tyr His Gln Val Leu Ala Thr His Gln Gln Ala Leu Asp Lys Ile Thr 
                645                 650                 655     


Gln Ala Leu Lys Ile Asn Asn Leu Arg Leu Ile Thr Leu Glu His Gln 
            660                 665                 670         


Val Leu Val Ile Gly Leu Lys Val Glu Ala Ile Glu Lys Phe Arg Tyr 
        675                 680                 685             


Thr Ala Phe Ala Met Gln Glu Leu Gly Cys Asn Gln Asn Gln Phe Phe 
    690                 695                 700                 


Cys Lys Ile Pro Pro Ser Leu Trp Ser Met Tyr Asn Met Thr Leu Asn 
705                 710                 715                 720 


Gln Thr Ile Trp Asn His Gly Asn Ile Ser Leu Gly Asn Trp Tyr Asn 
                725                 730                 735     


Gln Thr Lys Asp Leu Gln Asn Lys Phe Tyr Glu Ile Ile Met Asp Ile 
            740                 745                 750         


Glu Gln Asn Asn Val Gln Gly Lys Thr Gly Ile Gln Gln Leu Gln Lys 
        755                 760                 765             


Trp Glu Asn Trp Val Gly Trp Ile Gly Lys Ile Pro Gln Tyr Leu Lys 
    770                 775                 780                 


Gly Leu Leu Gly Ser Val Leu Gly Ile Gly Val Gly Ile Leu Leu Leu 
785                 790                 795                 800 


Ile Ile Cys Leu Pro Thr Leu Val Asp Cys Val Arg Asn Cys Ile Asn 
                805                 810                 815     


Lys Val Leu Gly Tyr Ser Val Ile Ala Met Pro Glu Leu Asp Asp Glu 
            820                 825                 830         


Glu Val Ser Met Glu Leu Arg Arg Asn Gly Arg Gln Cys Gly Met Ser 
        835                 840                 845             


Glu Lys Glu Glu Glu 
    850             


<210>  414
<211>  855
<212>  PRT
<213>  Artificial sequence

<220>
<223>  Mutated sequence

<400>  414

Met Ala Glu Gly Gly Phe Thr Gln Asn Gln Gln Trp Ile Gly Pro Glu 
1               5                   10                  15      


Glu Ala Glu Glu Leu Leu Asp Phe Asp Ile Ala Val Gln Met Asn Glu 
            20                  25                  30          


Glu Gly Pro Leu Asn Pro Gly Val Asn Pro Phe Arg Val Pro Gly Ile 
        35                  40                  45              


Thr Ser Gln Glu Lys Asp Asp Tyr Cys Lys Val Leu Gln Thr Lys Leu 
    50                  55                  60                  


Gln Glu Leu Lys Asn Glu Val Lys Glu Val Lys Ile Glu Glu Gly Asn 
65                  70                  75                  80  


Ala Gly Lys Phe Arg Arg Ala Arg Tyr Leu Arg Tyr Ser Asp Glu Asn 
                85                  90                  95      


Val Leu Ser Ile Val Tyr Leu Leu Ile Gly Tyr Leu Arg Tyr Leu Ile 
            100                 105                 110         


Asp His Arg Ser Leu Gly Ser Leu Arg His Asp Ile Asp Ile Glu Thr 
        115                 120                 125             


Pro Gln Glu Glu His Tyr Asn Asn Ser Glu Lys Gly Thr Thr Leu Asn 
    130                 135                 140                 


Thr Lys Tyr Gly Arg Arg Cys Cys Leu Ser Thr Phe Ile Met Tyr Leu 
145                 150                 155                 160 


Val Leu Phe Ala Gly Val Gly Leu Trp Leu Gly Ala Arg Ala Gln Val 
                165                 170                 175     


Val Trp Arg Leu Pro Pro Leu Val Val Pro Val Asp Asp Thr Glu Ile 
            180                 185                 190         


Ile Phe Trp Asp Cys Trp Ala Pro Glu Glu Pro Ala Cys Gln Asp Phe 
        195                 200                 205             


Leu Gly Thr Met Ile Tyr Leu Lys Ala Asn Val Asn Ile Ser Ile Gln 
    210                 215                 220                 


Glu Gly Pro Thr Leu Gly Asn Trp Ala Arg Glu Ile Trp Ser Thr Leu 
225                 230                 235                 240 


Phe Lys Lys Ala Thr Arg Gln Cys Arg Arg Gly Arg Ile Trp Lys Arg 
                245                 250                 255     


Trp Asn Glu Thr Ile Thr Gly Pro Leu Gly Cys Ala Thr Asn Thr Cys 
            260                 265                 270         


Tyr Asn Ile Ser Val Val Val Pro Asp Tyr Gln Cys Tyr Val Asp Arg 
        275                 280                 285             


Val Asp Thr Trp Leu Gln Gly Lys Val Asn Ile Ser Leu Cys Leu Thr 
    290                 295                 300                 


Gly Gly Lys Met Leu Tyr Asn Lys Glu Thr Arg Gln Leu Ser Tyr Cys 
305                 310                 315                 320 


Thr Asp Pro Leu Gln Ile Pro Leu Ile Asn Tyr Thr Phe Gly Pro Asn 
                325                 330                 335     


Gln Thr Cys Met Trp Asn Thr Ser Leu Ile Lys Asp Ser Glu Ile Pro 
            340                 345                 350         


Lys Cys Gly Trp Trp Asn Gln Val Ala Tyr Tyr Asn Ala Cys Lys Trp 
        355                 360                 365             


Glu Glu Ala Asn Val Thr Phe Gln Cys Gln Arg Thr Gln Ser Gln Ser 
    370                 375                 380                 


Gly Ser Trp Ile Arg Thr Ile Ser Ser Trp Lys Gln Arg Asn Arg Trp 
385                 390                 395                 400 


Glu Trp Arg Pro Asp Phe Glu Ser Glu Lys Val Lys Ile Ser Leu Gln 
                405                 410                 415     


Cys Asn Ser Thr Lys Asn Leu Thr Phe Ala Met Arg Ser Ser Ser Asp 
            420                 425                 430         


Tyr Tyr Asp Val Gln Gly Ala Trp Ile Glu Phe Gly Cys His Arg Asn 
        435                 440                 445             


Lys Ser Lys Lys Tyr Ser Glu Ala Arg Phe Arg Ile Arg Cys Lys Trp 
    450                 455                 460                 


Asn Glu Gly Lys Asn Ile Ser Leu Ile Asp Thr Cys Gly Thr Asn Pro 
465                 470                 475                 480 


Asn Val Thr Gly Ala Asn Pro Val Asp Cys Thr Met Lys Ala Asn Thr 
                485                 490                 495     


Met Tyr Asn Cys Ser Leu Gln Asp Ser Phe Thr Met Lys Ile Glu Asp 
            500                 505                 510         


Leu Ile Val His Phe Asn Met Thr Lys Ala Val Glu Met Tyr Asn Ile 
        515                 520                 525             


Ala Gly Asn Trp Ser Cys Thr Ser Asp Leu Pro Lys Gly Trp Gly Tyr 
    530                 535                 540                 


Met Asn Cys Asn Cys Thr Asn Gly Thr Asp Asn Ser Glu Thr Lys Met 
545                 550                 555                 560 


Thr Cys Pro Glu Asn Gln Gly Ile Leu Arg Asn Trp Tyr Asn Pro Val 
                565                 570                 575     


Ala Gly Leu Arg Gln Ala Leu Ile Lys Tyr Gln Val Val Lys Gln Pro 
            580                 585                 590         


Glu Tyr Leu Ile Val Pro Glu Glu Val Met Gln Tyr Lys Phe Lys Gln 
        595                 600                 605             


Lys Arg Ala Ala Ile His Ile Met Leu Ala Leu Ala Thr Val Leu Ser 
    610                 615                 620                 


Met Ala Gly Ala Gly Thr Gly Ala Thr Ala Ile Gly Met Val Thr Gln 
625                 630                 635                 640 


Tyr His Gln Val Leu Ala Thr His Gln Gln Ala Leu Glu Lys Ile Thr 
                645                 650                 655     


Glu Ala Leu Lys Ile Asn Asn Leu Arg Leu Ile Thr Leu Glu His Gln 
            660                 665                 670         


Val Leu Val Ile Gly Leu Lys Val Glu Ala Ile Glu Lys Arg Leu Tyr 
        675                 680                 685             


Thr Ala Phe Ala Met Gln Glu Leu Gly Cys His Gln Asn Gln Phe Phe 
    690                 695                 700                 


Cys Lys Ile Pro Pro Ser Leu Trp Ser Met Tyr Asn Met Thr Leu Asn 
705                 710                 715                 720 


Gln Thr Ile Trp Asn His Gly Asn Ile Ser Leu Gly Asn Trp Tyr Asn 
                725                 730                 735     


Gln Thr Arg Asp Leu Gln Asn Lys Phe Tyr Glu Ile Ile Met Asp Ile 
            740                 745                 750         


Glu Gln Asn Asn Val Gln Gly Lys Thr Gly Ile Gln Gln Leu Gln Lys 
        755                 760                 765             


Trp Glu Asn Trp Met Gly Trp Ile Gly Lys Ile Pro Gln Tyr Leu Lys 
    770                 775                 780                 


Gly Leu Leu Gly Ser Val Leu Gly Ile Gly Leu Gly Ile Leu Leu Leu 
785                 790                 795                 800 


Leu Ile Cys Leu Pro Thr Leu Val Asp Cys Ile Arg Asn Cys Thr Asn 
                805                 810                 815     


Lys Ile Leu Gly Tyr Thr Val Ile Ala Met Pro Glu Ile Asp Asp Glu 
            820                 825                 830         


Glu Val His Leu Ser Val Glu Leu Arg Arg Asn Gly Arg Gln Cys Gly 
        835                 840                 845             


Ile Ser Glu Lys Glu Glu Glu 
    850                 855 


<210>  415
<211>  855
<212>  PRT
<213>  Artificial sequence

<220>
<223>  Mutated sequence

<400>  415

Met Ala Glu Gly Gly Phe Thr Gln Asn Gln Gln Trp Ile Gly Pro Glu 
1               5                   10                  15      


Glu Ala Glu Glu Leu Leu Asp Phe Asp Ile Ala Val Gln Met Asn Glu 
            20                  25                  30          


Glu Gly Pro Leu Asn Pro Gly Val Asn Pro Phe Arg Val Pro Gly Ile 
        35                  40                  45              


Thr Ser Gln Glu Lys Asp Asp Tyr Cys Lys Val Leu Gln Thr Lys Leu 
    50                  55                  60                  


Gln Glu Leu Lys Asn Glu Val Lys Glu Val Lys Ile Glu Glu Gly Asn 
65                  70                  75                  80  


Ala Gly Lys Phe Arg Arg Ala Arg Tyr Leu Arg Tyr Ser Asp Glu Asn 
                85                  90                  95      


Val Leu Ser Ile Val Tyr Leu Leu Ile Gly Tyr Leu Arg Tyr Leu Ile 
            100                 105                 110         


Asp His Arg Ser Leu Gly Ser Leu Arg His Asp Ile Asp Ile Glu Thr 
        115                 120                 125             


Pro Gln Glu Glu His Tyr Asn Asn Ser Glu Lys Gly Thr Thr Leu Asn 
    130                 135                 140                 


Thr Lys Tyr Gly Arg Arg Cys Cys Leu Ser Thr Phe Ile Met Tyr Leu 
145                 150                 155                 160 


Val Leu Phe Ala Gly Val Gly Leu Trp Leu Gly Ala Arg Ala Gln Val 
                165                 170                 175     


Val Trp Arg Leu Pro Pro Leu Val Val Pro Val Asp Asp Thr Glu Ile 
            180                 185                 190         


Ile Phe Trp Asp Cys Trp Ala Pro Glu Glu Pro Ala Cys Gln Asp Phe 
        195                 200                 205             


Leu Gly Thr Met Ile Tyr Leu Lys Ala Asn Val Asn Ile Ser Ile Gln 
    210                 215                 220                 


Glu Gly Pro Thr Leu Gly Asn Trp Ala Arg Glu Ile Trp Ser Thr Leu 
225                 230                 235                 240 


Phe Lys Lys Ala Thr Arg Gln Cys Arg Arg Gly Arg Ile Trp Lys Arg 
                245                 250                 255     


Trp Asn Glu Thr Ile Thr Gly Pro Leu Gly Cys Ala Thr Asn Thr Cys 
            260                 265                 270         


Tyr Asn Ile Ser Val Val Val Pro Asp Tyr Gln Cys Tyr Val Asp Arg 
        275                 280                 285             


Val Asp Thr Trp Leu Gln Gly Lys Val Asn Ile Ser Leu Cys Leu Thr 
    290                 295                 300                 


Gly Gly Lys Met Leu Tyr Asn Lys Glu Thr Arg Gln Leu Ser Tyr Cys 
305                 310                 315                 320 


Thr Asp Pro Leu Gln Ile Pro Leu Ile Asn Tyr Thr Phe Gly Pro Asn 
                325                 330                 335     


Gln Thr Cys Met Trp Asn Thr Ser Leu Ile Lys Asp Ser Glu Ile Pro 
            340                 345                 350         


Lys Cys Gly Trp Trp Asn Gln Val Ala Tyr Tyr Asn Ala Cys Lys Trp 
        355                 360                 365             


Glu Glu Ala Asn Val Thr Phe Gln Cys Gln Arg Thr Gln Ser Gln Ser 
    370                 375                 380                 


Gly Ser Trp Ile Arg Thr Ile Ser Ser Trp Lys Gln Arg Asn Arg Trp 
385                 390                 395                 400 


Glu Trp Arg Pro Asp Phe Glu Ser Glu Lys Val Lys Ile Ser Leu Gln 
                405                 410                 415     


Cys Asn Ser Thr Lys Asn Leu Thr Phe Ala Met Arg Ser Ser Ser Asp 
            420                 425                 430         


Tyr Tyr Asp Val Gln Gly Ala Trp Ile Glu Phe Gly Cys His Arg Asn 
        435                 440                 445             


Lys Ser Lys Lys Tyr Ser Glu Ala Arg Phe Arg Ile Arg Cys Lys Trp 
    450                 455                 460                 


Asn Glu Gly Lys Asn Ile Ser Leu Ile Asp Thr Cys Gly Thr Asn Pro 
465                 470                 475                 480 


Asn Val Thr Gly Ala Asn Pro Val Asp Cys Thr Met Lys Ala Asn Thr 
                485                 490                 495     


Met Tyr Asn Cys Ser Leu Gln Asp Ser Phe Thr Met Lys Ile Glu Asp 
            500                 505                 510         


Leu Ile Val His Phe Asn Met Thr Lys Ala Val Glu Met Tyr Asn Ile 
        515                 520                 525             


Ala Gly Asn Trp Ser Cys Thr Ser Asp Leu Pro Lys Gly Trp Gly Tyr 
    530                 535                 540                 


Met Asn Cys Asn Cys Thr Asn Gly Thr Asp Asn Ser Glu Thr Lys Met 
545                 550                 555                 560 


Thr Cys Pro Glu Asn Gln Gly Ile Leu Arg Asn Trp Tyr Asn Pro Val 
                565                 570                 575     


Ala Gly Leu Arg Gln Ala Leu Ile Lys Tyr Gln Val Val Lys Gln Pro 
            580                 585                 590         


Glu Tyr Leu Ile Val Pro Glu Glu Val Met Gln Tyr Lys Phe Lys Gln 
        595                 600                 605             


Lys Arg Ala Ala Ile His Ile Met Leu Ala Leu Ala Thr Val Leu Ser 
    610                 615                 620                 


Met Ala Gly Ala Gly Thr Gly Ala Thr Ala Ile Gly Met Val Thr Gln 
625                 630                 635                 640 


Tyr His Gln Val Leu Ala Thr His Gln Gln Ala Leu Glu Lys Ile Thr 
                645                 650                 655     


Glu Ala Leu Lys Ile Asn Asn Leu Arg Leu Ile Thr Leu Glu His Gln 
            660                 665                 670         


Val Leu Val Ile Gly Leu Lys Val Glu Ala Ile Glu Lys Phe Arg Tyr 
        675                 680                 685             


Thr Ala Phe Ala Met Gln Glu Leu Gly Cys His Gln Asn Gln Phe Phe 
    690                 695                 700                 


Cys Lys Ile Pro Pro Ser Leu Trp Ser Met Tyr Asn Met Thr Leu Asn 
705                 710                 715                 720 


Gln Thr Ile Trp Asn His Gly Asn Ile Ser Leu Gly Asn Trp Tyr Asn 
                725                 730                 735     


Gln Thr Arg Asp Leu Gln Asn Lys Phe Tyr Glu Ile Ile Met Asp Ile 
            740                 745                 750         


Glu Gln Asn Asn Val Gln Gly Lys Thr Gly Ile Gln Gln Leu Gln Lys 
        755                 760                 765             


Trp Glu Asn Trp Met Gly Trp Ile Gly Lys Ile Pro Gln Tyr Leu Lys 
    770                 775                 780                 


Gly Leu Leu Gly Ser Val Leu Gly Ile Gly Leu Gly Ile Leu Leu Leu 
785                 790                 795                 800 


Leu Ile Cys Leu Pro Thr Leu Val Asp Cys Ile Arg Asn Cys Thr Asn 
                805                 810                 815     


Lys Ile Leu Gly Tyr Thr Val Ile Ala Met Pro Glu Ile Asp Asp Glu 
            820                 825                 830         


Glu Val His Leu Ser Val Glu Leu Arg Arg Asn Gly Arg Gln Cys Gly 
        835                 840                 845             


Ile Ser Glu Lys Glu Glu Glu 
    850                 855 


<210>  416
<211>  853
<212>  PRT
<213>  Artificial sequence

<220>
<223>  Mutated sequence

<400>  416

Met Ala Glu Gly Gly Phe Thr Gln Asn Gln Gln Trp Ile Gly Pro Glu 
1               5                   10                  15      


Glu Ala Glu Glu Leu Leu Asp Phe Asp Ile Ala Val Gln Met Asn Glu 
            20                  25                  30          


Glu Gly Pro Leu Asn Pro Gly Val Asn Pro Phe Arg Val Pro Gly Ile 
        35                  40                  45              


Thr Ser Gln Glu Lys Asp Asp Tyr Cys Lys Ile Leu Gln Thr Lys Leu 
    50                  55                  60                  


Arg Glu Leu Lys Asn Glu Val Lys Glu Val Lys Ile Glu Glu Gly Asn 
65                  70                  75                  80  


Ala Gly Lys Leu Arg Arg Ala Arg Tyr Leu Arg Tyr Ser Asp Glu Asn 
                85                  90                  95      


Val Leu Ser Ile Val Tyr Leu Leu Ile Gly Tyr Leu Arg Tyr Leu Ile 
            100                 105                 110         


Asp His Arg Ser Leu Gly Ser Leu Arg His Asp Ile Asp Ile Glu Thr 
        115                 120                 125             


Pro Gln Glu Glu His Tyr Asn Asn Ser Glu Lys Gly Thr Thr Leu Asn 
    130                 135                 140                 


Ile Lys Tyr Glu Gly Arg Cys Cys Leu Ser Thr Phe Ile Met His Leu 
145                 150                 155                 160 


Ile Leu Phe Ala Gly Val Gly Ile Trp Leu Gly Ala Arg Ala Gln Val 
                165                 170                 175     


Val Trp Arg Leu Pro Pro Leu Val Val Pro Val Asp Asp Thr Glu Met 
            180                 185                 190         


Ile Phe Trp Asp Cys Trp Ala Pro Glu Glu Pro Ala Cys Gln Asp Phe 
        195                 200                 205             


Leu Gly Thr Met Ile His Leu Lys Ala Asn Val Asn Ile Ser Ile Gln 
    210                 215                 220                 


Glu Gly Pro Thr Leu Gly Asn Trp Ala Arg Glu Ile Trp Ser Thr Leu 
225                 230                 235                 240 


Phe Lys Lys Ala Thr Arg Gln Cys Arg Arg Gly Lys Ile Trp Arg Arg 
                245                 250                 255     


Trp Asn Glu Thr Ile Thr Gly Pro Leu Gly Cys Ala Asn Asn Thr Cys 
            260                 265                 270         


Tyr Asn Ile Ser Val Val Val Pro Asp Tyr Gln Cys Tyr Val Asp Arg 
        275                 280                 285             


Val Asp Thr Trp Leu Gln Gly Lys Val Asn Ile Ser Leu Cys Leu Thr 
    290                 295                 300                 


Gly Gly Lys Met Leu Tyr Asn Lys Glu Thr Arg Gln Leu Ser Tyr Cys 
305                 310                 315                 320 


Thr Asp Pro Leu Gln Ile Pro Leu Ile Asn Tyr Thr Phe Gly Pro Asn 
                325                 330                 335     


Gln Thr Cys Met Trp Asn Ala Ser Leu Ile Lys Asp Ser Glu Ile Pro 
            340                 345                 350         


Lys Cys Gly Trp Trp Asn Gln Ala Ala Tyr Tyr Asn Ala Cys Lys Trp 
        355                 360                 365             


Glu Glu Ala Asn Val Thr Phe Gln Cys His Arg Thr Gln Ser Gln Ser 
    370                 375                 380                 


Gly Ser Trp Ile Arg Thr Ile Ser Ser Trp Arg Gln Arg Asn Arg Trp 
385                 390                 395                 400 


Glu Trp Arg Pro Asp Phe Glu Ser Glu Lys Val Lys Ile Ser Leu Gln 
                405                 410                 415     


Cys Asn Ser Thr Lys Asn Leu Thr Phe Ala Met Arg Ser Ser Ser Asp 
            420                 425                 430         


Tyr Tyr Asp Val Gln Gly Ala Trp Ile Glu Phe Gly Cys His Arg Lys 
        435                 440                 445             


Lys Ser Asn Lys His Ser Glu Ala Arg Phe Arg Ile Arg Cys Thr Trp 
    450                 455                 460                 


Asn Glu Gly Asn Asn Ile Ser Leu Ile Asp Thr Cys Gly Thr Asn Pro 
465                 470                 475                 480 


Asn Val Thr Gly Ala Asn Pro Val Asp Cys Thr Met Lys Ala Asn Val 
                485                 490                 495     


Met Tyr Asn Cys Thr Leu Gln Asp Ser Phe Thr Met Lys Ile Glu Asp 
            500                 505                 510         


Leu Ile Val His Phe Asn Met Thr Lys Ala Val Glu Met Tyr Asn Ile 
        515                 520                 525             


Ala Gly Asn Trp Ser Cys Thr Ser Asp Leu Pro Lys Gly Trp Gly Tyr 
    530                 535                 540                 


Met Asn Cys Asn Cys Thr Asn Gly Thr Asp Asn Thr Lys Met Thr Cys 
545                 550                 555                 560 


Pro Lys Asn Gln Gly Ile Leu Arg Asn Trp Tyr Asn Pro Val Ala Gly 
                565                 570                 575     


Leu Arg Gln Ala Leu Ile Lys Tyr Gln Val Val Lys Gln Pro Glu Tyr 
            580                 585                 590         


Leu Ile Val Pro Glu Glu Val Met Gln Tyr Lys Val Lys Gln Lys Arg 
        595                 600                 605             


Ala Ala Ile His Ile Met Leu Ala Leu Ala Thr Val Leu Ser Met Ala 
    610                 615                 620                 


Gly Ala Gly Thr Gly Ala Thr Ala Ile Gly Met Val Thr Gln Tyr His 
625                 630                 635                 640 


Gln Val Leu Ala Thr His Gln Gln Ala Leu Asp Lys Ile Thr Glu Ala 
                645                 650                 655     


Leu Lys Ile Asn Asn Leu Arg Leu Ile Thr Leu Glu His Gln Val Leu 
            660                 665                 670         


Val Ile Gly Leu Lys Val Glu Ala Ile Glu Lys Arg Leu Tyr Thr Ala 
        675                 680                 685             


Phe Ala Met Gln Glu Leu Gly Cys Asn Gln Asn Gln Phe Phe Cys Lys 
    690                 695                 700                 


Ile Pro Pro Ser Leu Trp Ser Met Tyr Asn Met Thr Leu Asn Gln Thr 
705                 710                 715                 720 


Ile Trp Asn His Gly Asn Ile Ser Leu Gly Asn Trp Tyr Asn Gln Thr 
                725                 730                 735     


Lys Asp Leu Gln Asn Lys Phe Tyr Glu Ile Ile Met Asp Ile Glu Gln 
            740                 745                 750         


Asn Asn Val Gln Gly Lys Thr Gly Ile Gln Gln Leu Gln Lys Trp Glu 
        755                 760                 765             


Asn Trp Val Gly Trp Ile Gly Lys Ile Pro Gln Tyr Leu Lys Gly Leu 
    770                 775                 780                 


Leu Gly Ser Val Leu Gly Ile Gly Leu Gly Ile Leu Leu Leu Leu Ile 
785                 790                 795                 800 


Cys Leu Pro Thr Leu Val Asp Cys Ile Arg Ser Cys Thr Asn Arg Ile 
                805                 810                 815     


Leu Gly Tyr Thr Val Ile Ala Met Pro Glu Ile Asp Asp Glu Glu Val 
            820                 825                 830         


His Leu Ser Val Glu Leu Arg Arg Asn Gly Arg Gln Cys Gly Ile Ser 
        835                 840                 845             


Glu Lys Glu Glu Glu 
    850             


<210>  417
<211>  853
<212>  PRT
<213>  Artificial sequence

<220>
<223>  Mutated sequence

<400>  417

Met Ala Glu Gly Gly Phe Thr Gln Asn Gln Gln Trp Ile Gly Pro Glu 
1               5                   10                  15      


Glu Ala Glu Glu Leu Leu Asp Phe Asp Ile Ala Val Gln Met Asn Glu 
            20                  25                  30          


Glu Gly Pro Leu Asn Pro Gly Val Asn Pro Phe Arg Val Pro Gly Ile 
        35                  40                  45              


Thr Ser Gln Glu Lys Asp Asp Tyr Cys Lys Ile Leu Gln Thr Lys Leu 
    50                  55                  60                  


Arg Glu Leu Lys Asn Glu Val Lys Glu Val Lys Ile Glu Glu Gly Asn 
65                  70                  75                  80  


Ala Gly Lys Leu Arg Arg Ala Arg Tyr Leu Arg Tyr Ser Asp Glu Asn 
                85                  90                  95      


Val Leu Ser Ile Val Tyr Leu Leu Ile Gly Tyr Leu Arg Tyr Leu Ile 
            100                 105                 110         


Asp His Arg Ser Leu Gly Ser Leu Arg His Asp Ile Asp Ile Glu Thr 
        115                 120                 125             


Pro Gln Glu Glu His Tyr Asn Asn Ser Glu Lys Gly Thr Thr Leu Asn 
    130                 135                 140                 


Ile Lys Tyr Glu Gly Arg Cys Cys Leu Ser Thr Phe Ile Met His Leu 
145                 150                 155                 160 


Ile Leu Phe Ala Gly Val Gly Ile Trp Leu Gly Ala Arg Ala Gln Val 
                165                 170                 175     


Val Trp Arg Leu Pro Pro Leu Val Val Pro Val Asp Asp Thr Glu Met 
            180                 185                 190         


Ile Phe Trp Asp Cys Trp Ala Pro Glu Glu Pro Ala Cys Gln Asp Phe 
        195                 200                 205             


Leu Gly Thr Met Ile His Leu Lys Ala Asn Val Asn Ile Ser Ile Gln 
    210                 215                 220                 


Glu Gly Pro Thr Leu Gly Asn Trp Ala Arg Glu Ile Trp Ser Thr Leu 
225                 230                 235                 240 


Phe Lys Lys Ala Thr Arg Gln Cys Arg Arg Gly Lys Ile Trp Arg Arg 
                245                 250                 255     


Trp Asn Glu Thr Ile Thr Gly Pro Leu Gly Cys Ala Asn Asn Thr Cys 
            260                 265                 270         


Tyr Asn Ile Ser Val Val Val Pro Asp Tyr Gln Cys Tyr Val Asp Arg 
        275                 280                 285             


Val Asp Thr Trp Leu Gln Gly Lys Val Asn Ile Ser Leu Cys Leu Thr 
    290                 295                 300                 


Gly Gly Lys Met Leu Tyr Asn Lys Glu Thr Arg Gln Leu Ser Tyr Cys 
305                 310                 315                 320 


Thr Asp Pro Leu Gln Ile Pro Leu Ile Asn Tyr Thr Phe Gly Pro Asn 
                325                 330                 335     


Gln Thr Cys Met Trp Asn Ala Ser Leu Ile Lys Asp Ser Glu Ile Pro 
            340                 345                 350         


Lys Cys Gly Trp Trp Asn Gln Ala Ala Tyr Tyr Asn Ala Cys Lys Trp 
        355                 360                 365             


Glu Glu Ala Asn Val Thr Phe Gln Cys His Arg Thr Gln Ser Gln Ser 
    370                 375                 380                 


Gly Ser Trp Ile Arg Thr Ile Ser Ser Trp Arg Gln Arg Asn Arg Trp 
385                 390                 395                 400 


Glu Trp Arg Pro Asp Phe Glu Ser Glu Lys Val Lys Ile Ser Leu Gln 
                405                 410                 415     


Cys Asn Ser Thr Lys Asn Leu Thr Phe Ala Met Arg Ser Ser Ser Asp 
            420                 425                 430         


Tyr Tyr Asp Val Gln Gly Ala Trp Ile Glu Phe Gly Cys His Arg Lys 
        435                 440                 445             


Lys Ser Asn Lys His Ser Glu Ala Arg Phe Arg Ile Arg Cys Thr Trp 
    450                 455                 460                 


Asn Glu Gly Asn Asn Ile Ser Leu Ile Asp Thr Cys Gly Thr Asn Pro 
465                 470                 475                 480 


Asn Val Thr Gly Ala Asn Pro Val Asp Cys Thr Met Lys Ala Asn Val 
                485                 490                 495     


Met Tyr Asn Cys Thr Leu Gln Asp Ser Phe Thr Met Lys Ile Glu Asp 
            500                 505                 510         


Leu Ile Val His Phe Asn Met Thr Lys Ala Val Glu Met Tyr Asn Ile 
        515                 520                 525             


Ala Gly Asn Trp Ser Cys Thr Ser Asp Leu Pro Lys Gly Trp Gly Tyr 
    530                 535                 540                 


Met Asn Cys Asn Cys Thr Asn Gly Thr Asp Asn Thr Lys Met Thr Cys 
545                 550                 555                 560 


Pro Lys Asn Gln Gly Ile Leu Arg Asn Trp Tyr Asn Pro Val Ala Gly 
                565                 570                 575     


Leu Arg Gln Ala Leu Ile Lys Tyr Gln Val Val Lys Gln Pro Glu Tyr 
            580                 585                 590         


Leu Ile Val Pro Glu Glu Val Met Gln Tyr Lys Val Lys Gln Lys Arg 
        595                 600                 605             


Ala Ala Ile His Ile Met Leu Ala Leu Ala Thr Val Leu Ser Met Ala 
    610                 615                 620                 


Gly Ala Gly Thr Gly Ala Thr Ala Ile Gly Met Val Thr Gln Tyr His 
625                 630                 635                 640 


Gln Val Leu Ala Thr His Gln Gln Ala Leu Asp Lys Ile Thr Glu Ala 
                645                 650                 655     


Leu Lys Ile Asn Asn Leu Arg Leu Ile Thr Leu Glu His Gln Val Leu 
            660                 665                 670         


Val Ile Gly Leu Lys Val Glu Ala Ile Glu Lys Phe Arg Tyr Thr Ala 
        675                 680                 685             


Phe Ala Met Gln Glu Leu Gly Cys Asn Gln Asn Gln Phe Phe Cys Lys 
    690                 695                 700                 


Ile Pro Pro Ser Leu Trp Ser Met Tyr Asn Met Thr Leu Asn Gln Thr 
705                 710                 715                 720 


Ile Trp Asn His Gly Asn Ile Ser Leu Gly Asn Trp Tyr Asn Gln Thr 
                725                 730                 735     


Lys Asp Leu Gln Asn Lys Phe Tyr Glu Ile Ile Met Asp Ile Glu Gln 
            740                 745                 750         


Asn Asn Val Gln Gly Lys Thr Gly Ile Gln Gln Leu Gln Lys Trp Glu 
        755                 760                 765             


Asn Trp Val Gly Trp Ile Gly Lys Ile Pro Gln Tyr Leu Lys Gly Leu 
    770                 775                 780                 


Leu Gly Ser Val Leu Gly Ile Gly Leu Gly Ile Leu Leu Leu Leu Ile 
785                 790                 795                 800 


Cys Leu Pro Thr Leu Val Asp Cys Ile Arg Ser Cys Thr Asn Arg Ile 
                805                 810                 815     


Leu Gly Tyr Thr Val Ile Ala Met Pro Glu Ile Asp Asp Glu Glu Val 
            820                 825                 830         


His Leu Ser Val Glu Leu Arg Arg Asn Gly Arg Gln Cys Gly Ile Ser 
        835                 840                 845             


Glu Lys Glu Glu Glu 
    850             


<210>  418
<211>  855
<212>  PRT
<213>  Artificial sequence

<220>
<223>  Mutated sequence

<400>  418

Met Ala Asp Gly Gly Phe Ser Gln Asn Gln Gln Trp Ile Gly Pro Glu 
1               5                   10                  15      


Glu Ala Glu Lys Ser Leu Asp Phe Asp Ile Ala Thr Gln Met Asn Glu 
            20                  25                  30          


Glu Gly Pro Leu Asn Pro Gly Val Asn Pro Phe Arg Val Pro Gly Ile 
        35                  40                  45              


Thr Pro Gln Glu Lys Glu Asp Tyr Cys Lys Ile Leu Gln Thr Arg Leu 
    50                  55                  60                  


Gln Glu Leu Lys Asn Glu Leu Lys Glu Val Lys Val Glu Gln Arg Asn 
65                  70                  75                  80  


Ala Gly Lys Phe Arg Arg Thr Arg Phe Leu Arg Tyr Ser Asp Glu Asn 
                85                  90                  95      


Val Leu Ser Ile Val Tyr Leu Leu Ile Gly Tyr Leu Arg Tyr Leu Ile 
            100                 105                 110         


Asp Arg Arg Ser Leu Gly Ser Leu Arg His Asp Ile Asp Ile Lys Ile 
        115                 120                 125             


Pro Gln Glu Glu His Tyr Asn Asn Ser Ala Lys Asp Thr Thr Leu Asn 
    130                 135                 140                 


Ile Lys Tyr Glu Arg Arg Cys Cys Ile Gly Thr Phe Ile Met Tyr Leu 
145                 150                 155                 160 


Ile Leu Phe Ala Gly Ile Gly Ile Trp Phe Gly Ala Lys Ala Gln Val 
                165                 170                 175     


Val Trp Arg Leu Pro Pro Leu Val Val Pro Val Glu Glu Ser Glu Ile 
            180                 185                 190         


Ile Phe Trp Asp Cys Trp Ala Pro Glu Glu Pro Ala Cys Gln Asp Phe 
        195                 200                 205             


Leu Gly Ala Met Ile His Leu Lys Ala Asn Thr Asn Ile Ser Ile Gln 
    210                 215                 220                 


Glu Gly Pro Thr Leu Gly Asn Trp Ala Arg Glu Ile Trp Ser Thr Leu 
225                 230                 235                 240 


Phe Lys Lys Ala Thr Lys Gln Cys Arg Lys Gly Gly Ile Trp Thr Lys 
                245                 250                 255     


Trp Lys Glu Thr Ile Thr Gly Pro Leu Gly Cys Ala Asn Asn Thr Cys 
            260                 265                 270         


Tyr Asn Ile Ser Val Val Val Pro Asp Tyr Gln Cys Tyr Val Asp Arg 
        275                 280                 285             


Val Asp Thr Trp Leu Gln Gly Lys Val Asn Ile Ser Leu Cys Leu Thr 
    290                 295                 300                 


Gly Gly Lys Met Leu Phe Asn Lys Glu Thr Lys Gln Leu Ser Tyr Cys 
305                 310                 315                 320 


Thr Asp Pro Leu Gln Ile Pro Leu Ile Asn Tyr Thr Phe Gly Pro Asn 
                325                 330                 335     


Gln Thr Cys Met Trp Asn Thr Ser Gln Ile Gln Asp Ser Glu Ile Pro 
            340                 345                 350         


Lys Cys Gly Trp Trp Asn Gln Ile Ala Tyr Tyr Asn Ser Cys Gln Trp 
        355                 360                 365             


Glu Lys Thr Asp Val Lys Phe His Cys Gln Arg Thr Gln Ser Gln Pro 
    370                 375                 380                 


Gly Ser Trp Arg Arg Ala Ile Ser Ser Trp Arg Gln Arg Asn Arg Trp 
385                 390                 395                 400 


Glu Trp Arg Pro Asp Phe Glu Ser Lys Lys Val Lys Val Ser Leu Lys 
                405                 410                 415     


Cys Asn Ser Thr Lys Asn Leu Thr Phe Ala Met Arg Ser Ser Gly Asp 
            420                 425                 430         


Tyr Gly Glu Val Thr Gly Ala Trp Ile Glu Phe Gly Cys His Arg Asn 
        435                 440                 445             


Lys Ser Lys Leu His Thr Glu Ala Arg Phe Arg Ile Arg Cys Lys Trp 
    450                 455                 460                 


Asn Glu Gly Asn Asn Ile Ser Leu Ile Asp Thr Cys Gly Thr Asn Pro 
465                 470                 475                 480 


Asn Val Ala Glu Ala Asn Pro Val Asp Cys Thr Met Lys Ala Asn Thr 
                485                 490                 495     


Met Tyr Asn Cys Ser Leu Gln Asp Ser Phe Thr Met Lys Ile Glu Asp 
            500                 505                 510         


Leu Ile Val His Phe Asn Met Thr Lys Ala Val Glu Met Tyr Asn Ile 
        515                 520                 525             


Ala Gly Asn Trp Ser Cys Thr Ser Asp Leu Pro Lys Gly Trp Gly Tyr 
    530                 535                 540                 


Met Asn Cys Asn Cys Thr Asn Gly Thr Thr Ser Asn Gly Ile Lys Met 
545                 550                 555                 560 


Ala Cys Pro Lys Gln Gln Gly Ile Leu Arg Asn Trp Tyr Asn Pro Val 
                565                 570                 575     


Ala Gly Leu Arg Gln Ala Leu Ile Lys Tyr Gln Val Val Lys Gln Pro 
            580                 585                 590         


Glu Tyr Leu Ile Val Pro Glu Glu Val Leu Gln Tyr Lys Phe Lys Gln 
        595                 600                 605             


Lys Arg Ala Ala Ile His Ile Met Leu Ala Leu Ala Thr Val Leu Ser 
    610                 615                 620                 


Met Ala Gly Ala Gly Thr Gly Ala Thr Ala Ile Gly Val Val Thr Gln 
625                 630                 635                 640 


Tyr His Gln Val Leu Ala Thr His Gln Gln Ala Leu Asp Lys Ile Thr 
                645                 650                 655     


Glu Ala Leu Lys Ile Asn Asn Leu Arg Leu Ile Thr Leu Glu His Gln 
            660                 665                 670         


Val Leu Val Ile Gly Leu Lys Val Glu Ala Ile Glu Lys Arg Leu Tyr 
        675                 680                 685             


Thr Ala Phe Ala Met Gln Glu Leu Gly Cys Asn Gln Asn Gln Phe Phe 
    690                 695                 700                 


Cys Lys Ile Pro Leu Asn Leu Trp Asn Met Tyr Asn Met Thr Leu Asn 
705                 710                 715                 720 


Gln Thr Ile Trp Asn His Gly Asn Ile Ser Leu Gly Asn Trp Tyr Asn 
                725                 730                 735     


Gln Thr Arg Asp Leu Gln Asn Lys Phe Tyr Glu Ile Ile Met Asp Ile 
            740                 745                 750         


Glu Gln Asn Asn Val Gln Gly His Thr Gly Ile Gln Gln Leu Gln Lys 
        755                 760                 765             


Trp Glu Asn Trp Val Gly Trp Ile Gly Lys Ile Pro Gln Tyr Leu Lys 
    770                 775                 780                 


Gly Leu Ile Gly Ser Val Leu Gly Ile Gly Leu Gly Ile Leu Leu Leu 
785                 790                 795                 800 


Leu Ile Cys Leu Pro Thr Leu Val Asp Cys Ile Arg Ser Cys Thr Asn 
                805                 810                 815     


Lys Met Leu Gly Tyr Thr Val Ile Ala Met Pro Glu Ile Gly Asp Glu 
            820                 825                 830         


Gly Val His Leu Ala Met Glu Leu Arg Arg Asn Gly Arg Gln Cys Gly 
        835                 840                 845             


Ile Ser Glu Lys Glu Glu Glu 
    850                 855 


<210>  419
<211>  855
<212>  PRT
<213>  Artificial sequence

<220>
<223>  Mutated sequence

<400>  419

Met Ala Asp Gly Gly Phe Ser Gln Asn Gln Gln Trp Ile Gly Pro Glu 
1               5                   10                  15      


Glu Ala Glu Lys Ser Leu Asp Phe Asp Ile Ala Thr Gln Met Asn Glu 
            20                  25                  30          


Glu Gly Pro Leu Asn Pro Gly Val Asn Pro Phe Arg Val Pro Gly Ile 
        35                  40                  45              


Thr Pro Gln Glu Lys Glu Asp Tyr Cys Lys Ile Leu Gln Thr Arg Leu 
    50                  55                  60                  


Gln Glu Leu Lys Asn Glu Leu Lys Glu Val Lys Val Glu Gln Arg Asn 
65                  70                  75                  80  


Ala Gly Lys Phe Arg Arg Thr Arg Phe Leu Arg Tyr Ser Asp Glu Asn 
                85                  90                  95      


Val Leu Ser Ile Val Tyr Leu Leu Ile Gly Tyr Leu Arg Tyr Leu Ile 
            100                 105                 110         


Asp Arg Arg Ser Leu Gly Ser Leu Arg His Asp Ile Asp Ile Lys Ile 
        115                 120                 125             


Pro Gln Glu Glu His Tyr Asn Asn Ser Ala Lys Asp Thr Thr Leu Asn 
    130                 135                 140                 


Ile Lys Tyr Glu Arg Arg Cys Cys Ile Gly Thr Phe Ile Met Tyr Leu 
145                 150                 155                 160 


Ile Leu Phe Ala Gly Ile Gly Ile Trp Phe Gly Ala Lys Ala Gln Val 
                165                 170                 175     


Val Trp Arg Leu Pro Pro Leu Val Val Pro Val Glu Glu Ser Glu Ile 
            180                 185                 190         


Ile Phe Trp Asp Cys Trp Ala Pro Glu Glu Pro Ala Cys Gln Asp Phe 
        195                 200                 205             


Leu Gly Ala Met Ile His Leu Lys Ala Asn Thr Asn Ile Ser Ile Gln 
    210                 215                 220                 


Glu Gly Pro Thr Leu Gly Asn Trp Ala Arg Glu Ile Trp Ser Thr Leu 
225                 230                 235                 240 


Phe Lys Lys Ala Thr Lys Gln Cys Arg Lys Gly Gly Ile Trp Thr Lys 
                245                 250                 255     


Trp Lys Glu Thr Ile Thr Gly Pro Leu Gly Cys Ala Asn Asn Thr Cys 
            260                 265                 270         


Tyr Asn Ile Ser Val Val Val Pro Asp Tyr Gln Cys Tyr Val Asp Arg 
        275                 280                 285             


Val Asp Thr Trp Leu Gln Gly Lys Val Asn Ile Ser Leu Cys Leu Thr 
    290                 295                 300                 


Gly Gly Lys Met Leu Phe Asn Lys Glu Thr Lys Gln Leu Ser Tyr Cys 
305                 310                 315                 320 


Thr Asp Pro Leu Gln Ile Pro Leu Ile Asn Tyr Thr Phe Gly Pro Asn 
                325                 330                 335     


Gln Thr Cys Met Trp Asn Thr Ser Gln Ile Gln Asp Ser Glu Ile Pro 
            340                 345                 350         


Lys Cys Gly Trp Trp Asn Gln Ile Ala Tyr Tyr Asn Ser Cys Gln Trp 
        355                 360                 365             


Glu Lys Thr Asp Val Lys Phe His Cys Gln Arg Thr Gln Ser Gln Pro 
    370                 375                 380                 


Gly Ser Trp Arg Arg Ala Ile Ser Ser Trp Arg Gln Arg Asn Arg Trp 
385                 390                 395                 400 


Glu Trp Arg Pro Asp Phe Glu Ser Lys Lys Val Lys Val Ser Leu Lys 
                405                 410                 415     


Cys Asn Ser Thr Lys Asn Leu Thr Phe Ala Met Arg Ser Ser Gly Asp 
            420                 425                 430         


Tyr Gly Glu Val Thr Gly Ala Trp Ile Glu Phe Gly Cys His Arg Asn 
        435                 440                 445             


Lys Ser Lys Leu His Thr Glu Ala Arg Phe Arg Ile Arg Cys Lys Trp 
    450                 455                 460                 


Asn Glu Gly Asn Asn Ile Ser Leu Ile Asp Thr Cys Gly Thr Asn Pro 
465                 470                 475                 480 


Asn Val Ala Glu Ala Asn Pro Val Asp Cys Thr Met Lys Ala Asn Thr 
                485                 490                 495     


Met Tyr Asn Cys Ser Leu Gln Asp Ser Phe Thr Met Lys Ile Glu Asp 
            500                 505                 510         


Leu Ile Val His Phe Asn Met Thr Lys Ala Val Glu Met Tyr Asn Ile 
        515                 520                 525             


Ala Gly Asn Trp Ser Cys Thr Ser Asp Leu Pro Lys Gly Trp Gly Tyr 
    530                 535                 540                 


Met Asn Cys Asn Cys Thr Asn Gly Thr Thr Ser Asn Gly Ile Lys Met 
545                 550                 555                 560 


Ala Cys Pro Lys Gln Gln Gly Ile Leu Arg Asn Trp Tyr Asn Pro Val 
                565                 570                 575     


Ala Gly Leu Arg Gln Ala Leu Ile Lys Tyr Gln Val Val Lys Gln Pro 
            580                 585                 590         


Glu Tyr Leu Ile Val Pro Glu Glu Val Leu Gln Tyr Lys Phe Lys Gln 
        595                 600                 605             


Lys Arg Ala Ala Ile His Ile Met Leu Ala Leu Ala Thr Val Leu Ser 
    610                 615                 620                 


Met Ala Gly Ala Gly Thr Gly Ala Thr Ala Ile Gly Val Val Thr Gln 
625                 630                 635                 640 


Tyr His Gln Val Leu Ala Thr His Gln Gln Ala Leu Asp Lys Ile Thr 
                645                 650                 655     


Glu Ala Leu Lys Ile Asn Asn Leu Arg Leu Ile Thr Leu Glu His Gln 
            660                 665                 670         


Val Leu Val Ile Gly Leu Lys Val Glu Ala Ile Glu Lys Phe Arg Tyr 
        675                 680                 685             


Thr Ala Phe Ala Met Gln Glu Leu Gly Cys Asn Gln Asn Gln Phe Phe 
    690                 695                 700                 


Cys Lys Ile Pro Leu Asn Leu Trp Asn Met Tyr Asn Met Thr Leu Asn 
705                 710                 715                 720 


Gln Thr Ile Trp Asn His Gly Asn Ile Ser Leu Gly Asn Trp Tyr Asn 
                725                 730                 735     


Gln Thr Arg Asp Leu Gln Asn Lys Phe Tyr Glu Ile Ile Met Asp Ile 
            740                 745                 750         


Glu Gln Asn Asn Val Gln Gly His Thr Gly Ile Gln Gln Leu Gln Lys 
        755                 760                 765             


Trp Glu Asn Trp Val Gly Trp Ile Gly Lys Ile Pro Gln Tyr Leu Lys 
    770                 775                 780                 


Gly Leu Ile Gly Ser Val Leu Gly Ile Gly Leu Gly Ile Leu Leu Leu 
785                 790                 795                 800 


Leu Ile Cys Leu Pro Thr Leu Val Asp Cys Ile Arg Ser Cys Thr Asn 
                805                 810                 815     


Lys Met Leu Gly Tyr Thr Val Ile Ala Met Pro Glu Ile Gly Asp Glu 
            820                 825                 830         


Gly Val His Leu Ala Met Glu Leu Arg Arg Asn Gly Arg Gln Cys Gly 
        835                 840                 845             


Ile Ser Glu Lys Glu Glu Glu 
    850                 855 


<210>  420
<211>  904
<212>  PRT
<213>  Artificial sequence

<220>
<223>  Mutated sequence

<400>  420

Met Asp Gln Asp Leu Asp Gly Ala Glu Arg Gly Glu Arg Gly Gly Gly 
1               5                   10                  15      


Ser Glu Glu Leu Leu Gln Glu Glu Ile Asn Glu Gly Arg Leu Thr Ala 
            20                  25                  30          


Arg Glu Ala Leu Gln Thr Trp Ile Asn Asn Gly Glu Ile His Pro Trp 
        35                  40                  45              


Val Leu Ala Gly Met Leu Ser Met Gly Val Gly Met Leu Leu Gly Val 
    50                  55                  60                  


Tyr Cys Gln Leu Pro Asp Thr Leu Ile Trp Ile Leu Met Phe Gln Leu 
65                  70                  75                  80  


Cys Leu Tyr Trp Gly Leu Gly Glu Thr Ser Arg Glu Leu Asp Lys Asp 
                85                  90                  95      


Ser Trp Gln Trp Val Arg Ser Val Phe Ile Ile Ala Ile Leu Gly Thr 
            100                 105                 110         


Leu Thr Met Ala Gly Thr Ala Leu Ala Asp Asp Asp Gln Ser Thr Leu 
        115                 120                 125             


Ile Pro Asn Ile Thr Lys Ile Pro Thr Lys Asp Thr Glu Pro Gly Cys 
    130                 135                 140                 


Thr Tyr Pro Trp Ile Leu Ile Leu Leu Ile Leu Ala Phe Ile Leu Gly 
145                 150                 155                 160 


Ile Leu Gly Ile Ile Leu Val Leu Arg Arg Ser Asn Ser Glu Asp Ile 
                165                 170                 175     


Leu Ala Ala Arg Asp Thr Ile Asp Trp Trp Leu Ser Ala Asn Gln Glu 
            180                 185                 190         


Ile Pro Pro Lys Phe Ala Phe Pro Ile Ile Leu Ile Ser Ser Pro Leu 
        195                 200                 205             


Ala Gly Ile Ile Gly Tyr Tyr Val Met Glu Arg His Leu Glu Ile Phe 
    210                 215                 220                 


Lys Lys Gly Cys Gln Ile Cys Gly Ser Leu Ser Ser Met Trp Gly Met 
225                 230                 235                 240 


Leu Leu Glu Glu Ile Gly Arg Trp Leu Ala Arg Arg Glu Trp Asn Val 
                245                 250                 255     


Ser Arg Val Met Val Ile Leu Leu Ile Ser Phe Ser Trp Gly Met Tyr 
            260                 265                 270         


Val Asn Arg Val Asn Ala Ser Gly Ser His Val Ala Met Val Thr Ser 
        275                 280                 285             


Pro Pro Gly Tyr Arg Ile Val Asn Asp Thr Ser Gln Ala Pro Trp Tyr 
    290                 295                 300                 


Cys Phe Ser Ser Ala Pro Ile Pro Thr Cys Ser Ser Ser Gln Trp Gly 
305                 310                 315                 320 


Asp Lys Tyr Phe Glu Glu Lys Ile Asn Glu Thr Leu Val Lys Gln Val 
                325                 330                 335     


Tyr Glu Gln Ala Ala Lys His Ser Arg Ala Thr Trp Ile Glu Pro Asp 
            340                 345                 350         


Leu Leu Glu Glu Ala Val Tyr Glu Leu Ala Leu Leu Ser Ala Asn Asp 
        355                 360                 365             


Ser Arg Gln Val Val Val Glu Asn Gly Thr Asp Val Cys Ser Ser Gln 
    370                 375                 380                 


Asn Ser Ser Thr Asn Lys Gly His Pro Met Thr Leu Leu Lys Leu Arg 
385                 390                 395                 400 


Gly Gln Val Ser Glu Thr Trp Ile Gly Asn Ser Ser Leu Gln Phe Cys 
                405                 410                 415     


Val Gln Trp Pro Tyr Val Leu Val Gly Leu Asn Asn Ser Asp Ser Asn 
            420                 425                 430         


Ile Ser Phe Asn Ser Gly Asp Trp Ile Ala Thr Asn Cys Met His Pro 
        435                 440                 445             


Ile Thr Leu Asn Lys Ser Ala Gln Asp Leu Gly Lys Asn Phe Pro Arg 
    450                 455                 460                 


Leu Thr Phe Leu Asp Gly Gln Leu Ser Gln Leu Lys Asn Thr Leu Cys 
465                 470                 475                 480 


Gly His Asn Thr Asn Cys Leu Lys Phe Gly Asn Lys Ser Phe Ser Thr 
                485                 490                 495     


Asn Ser Leu Ile Leu Cys Gln Asp Asn Pro Ile Gly Asn Asp Thr Phe 
            500                 505                 510         


Tyr Ser Leu Ser His Ser Phe Ser Lys Gln Ala Ser Ala Arg Trp Ile 
        515                 520                 525             


Leu Val Lys Val Pro Ser Tyr Gly Phe Val Val Val Asn Asp Thr Asp 
    530                 535                 540                 


Thr Pro Pro Ser Leu Arg Ile Arg Lys Pro Arg Ala Val Gly Leu Ala 
545                 550                 555                 560 


Ile Phe Leu Leu Val Leu Ala Ile Met Ala Ile Thr Ser Ser Leu Val 
                565                 570                 575     


Ala Ala Thr Thr Leu Val Asn Gln His Thr Thr Ala Lys Val Val Glu 
            580                 585                 590         


Arg Val Val Gln Asn Val Ser Tyr Ile Ala Gln Thr Gln Asp Gln Phe 
        595                 600                 605             


Thr His Leu Phe Arg Asn Ile Asn Asn Arg Leu Asn Val Leu His His 
    610                 615                 620                 


Arg Val Ser Tyr Leu Glu Tyr Arg Glu Glu Ile Arg Gln Lys Gln Val 
625                 630                 635                 640 


Phe Phe Gly Cys Lys Pro His Gly Arg Tyr Cys His Phe Asp Phe Gly 
                645                 650                 655     


Pro Glu Glu Val Gly Trp Asn Asn Ser Trp Asn Ser Lys Thr Trp Asn 
            660                 665                 670         


Asp Leu Gln Asp Glu Tyr Asp Lys Ile Glu Glu Lys Ile Leu Lys Ile 
        675                 680                 685             


Arg Val Asp Trp Leu Asn Ser Ser Leu Ser Asp Thr Gln Asp Thr Phe 
    690                 695                 700                 


Gly Leu Glu Thr Ser Ile Phe Asp His Leu Val Gln Leu Phe Asp Trp 
705                 710                 715                 720 


Thr Ser Trp Lys Asp Trp Ile Lys Ile Ile Ile Val Ile Ile Val Leu 
                725                 730                 735     


Trp Leu Leu Ile Lys Ile Leu Leu Gly Met Leu Arg Ser Cys Ala Lys 
            740                 745                 750         


Val Ser Gln Asn Tyr Gln His Leu Pro Ala Glu Glu Glu Asp Gly Asp 
        755                 760                 765             


Thr Glu Pro Glu Ser Ser Pro Ala Arg Gly Asp Pro Ala Ser Gly Ser 
    770                 775                 780                 


Leu Tyr Glu Asn Trp Leu Asn Lys Ile Gly Glu Ser Lys Asn Asp Ala 
785                 790                 795                 800 


Tyr Arg Val Trp Thr Glu Glu Tyr Asn Ser Leu Arg Ile Leu Phe Ala 
                805                 810                 815     


Thr Cys Arg Trp Asp Leu Leu Thr Pro Gln Leu Leu Gln Leu Pro Phe 
            820                 825                 830         


Phe Leu Leu Thr Leu Leu Leu Lys Leu Leu Trp Asp Ile Phe Arg His 
        835                 840                 845             


Ala Pro Ile Leu Asn Leu Lys Gly Trp Thr Val Gly Gln Gly Gly Thr 
    850                 855                 860                 


Ser Gly Gln Gln Gln Pro Pro Asp Phe Pro Tyr Val Asn Trp Thr Gly 
865                 870                 875                 880 


Ser Arg Glu Gln Asn Asn Pro Glu Gly Gly Leu Asp Ser Gly Ala Trp 
                885                 890                 895     


Tyr Glu Gly Leu Arg Gly Ser Gln 
            900                 


<210>  421
<211>  9
<212>  PRT
<213>  Artificial sequence

<220>
<223>  Mutated sequence


<220>
<221>  MISC_FEATURE
<222>  (3)..(7)
<223>  Xaa is any naturally occurring amino acid or is mutated

<220>
<221>  MISC_FEATURE
<222>  (8)..(8)
<223>  Xaa is Ile or Val

<220>
<221>  MISC_FEATURE
<222>  (9)..(9)
<223>  Xaa is Arg or His

<400>  421

Tyr Leu Xaa Xaa Xaa Xaa Xaa Xaa Xaa 
1               5                   


<210>  422
<211>  14
<212>  PRT
<213>  Artificial sequence

<220>
<223>  Mutated sequence


<220>
<221>  MISC_FEATURE
<222>  (2)..(2)
<223>  Xaa is Ser or Thr

<220>
<221>  MISC_FEATURE
<222>  (5)..(9)
<223>  Xaa is any naturally occurring amino acid or is mutated

<220>
<221>  MISC_FEATURE
<222>  (10)..(10)
<223>  Xaa is Ile or Val

<220>
<221>  MISC_FEATURE
<222>  (11)..(11)
<223>  Xaa is Arg or His

<220>
<221>  MISC_FEATURE
<222>  (12)..(12)
<223>  Xaa is Glu or Gln

<220>
<221>  MISC_FEATURE
<222>  (13)..(13)
<223>  Xaa is Lys or Leu or Val

<400>  422

Val Xaa Tyr Leu Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Gln 
1               5                   10                  


<210>  423
<211>  782
<212>  PRT
<213>  Artificial sequence

<220>
<223>  Mutated sequence

<400>  423

Met Met Glu Glu Gly Arg Lys Glu Glu Pro Glu Glu Arg Gly Glu Lys 
1               5                   10                  15      


Ser Thr Met Arg Asp Leu Leu Gln Arg Ala Val Asp Lys Gly His Leu 
            20                  25                  30          


Thr Ala Arg Glu Ala Leu Asp Arg Trp Thr Leu Glu Asp His Gly Glu 
        35                  40                  45              


Ile His Pro Trp Ile Ile Leu Phe Cys Phe Ala Gly Ala Ile Gly Val 
    50                  55                  60                  


Ile Gly Gly Trp Gly Leu Arg Gly Glu Leu Asn Val Cys Met Leu Ile 
65                  70                  75                  80  


Ala Leu Val Val Leu Val Pro Ile Tyr Trp Gly Ile Gly Glu Ala Ala 
                85                  90                  95      


Arg Asn Ile Asp Ser Leu Asp Trp Gln Trp Val Arg Lys Val Phe Ile 
            100                 105                 110         


Val Ile Ile Leu Val Leu Val Gly Leu Leu Gly Gly Ser Cys Ser Ala 
        115                 120                 125             


Gln Arg Gln His Val Ala Met Leu Leu Ser Pro Pro Gly Ile Arg Leu 
    130                 135                 140                 


Pro Ser Thr Val Asp Ile Pro Trp Phe Cys Ile Ser Asn Ala Pro Ile 
145                 150                 155                 160 


Pro Asp Cys Val His Trp Thr Val Gln Lys Pro Asp Gln Lys His Gln 
                165                 170                 175     


Gln Ile Glu Asn Val Met Gly Leu Gln Glu Val Leu Asp Asn Ala Thr 
            180                 185                 190         


Phe Phe Glu Val Pro Asp Leu Phe Asp Arg Val Tyr Leu Glu Leu Ala 
        195                 200                 205             


Arg Leu Asp Ala Asn Ser Thr Gly Val Pro Val Asn Ile Pro Pro Thr 
    210                 215                 220                 


Gly Ile Gly Gln Val Lys Gly Asp Cys Ser Thr Gly Asp Ile Gln Gly 
225                 230                 235                 240 


Ile Asn Glu Thr Leu Ser Thr Arg Gly Thr Leu Gly Glu Lys Thr Phe 
                245                 250                 255     


Leu Ser Ile Arg Pro Gly Gly Trp Phe Thr Asn Thr Thr Val Trp Phe 
            260                 265                 270         


Cys Val His Trp Pro Phe Gly Phe Ile Gln Arg Lys Glu Asn Leu Ser 
        275                 280                 285             


Glu Gly Ser Ala Gln Val Arg Asn Cys Leu Asp Pro Ile Asn Val Thr 
    290                 295                 300                 


Glu Pro Lys Val Ala Asn Tyr Ser Tyr Cys Pro Leu Glu Tyr Lys Gly 
305                 310                 315                 320 


Lys Asn Tyr Ile Asn Lys Gly Leu Glu Cys Val Gly Gly Arg Val Asp 
                325                 330                 335     


Leu Ser Ser Asn Pro Glu Gln His Thr Asp Leu Leu Ala Cys Gly Thr 
            340                 345                 350         


Phe Cys Gln Asn Phe Arg Ser Cys Asp Met Val Ser Arg Asp Ile Leu 
        355                 360                 365             


Ile Gly Tyr His Pro Ser Gln Gln Arg Gln His Ile Tyr Ile Asn His 
    370                 375                 380                 


Thr Phe Trp Glu Gln Ala Asn Thr Arg Trp Ile Leu Val Gln Val Pro 
385                 390                 395                 400 


Asn Tyr Gly Phe Val Pro Val Pro Asp Thr Glu Arg Pro Trp Lys Gly 
                405                 410                 415     


Gly Lys Thr Arg Gly Lys Arg Ala Val Gly Met Val Ile Phe Leu Leu 
            420                 425                 430         


Val Leu Ala Ile Met Ala Met Thr Ala Ser Val Thr Ala Ala Ala Thr 
        435                 440                 445             


Leu Val Lys Gln His Ala Thr Ala Gln Val Val Gly Arg Leu Ser Thr 
    450                 455                 460                 


Asn Leu Thr Tyr Ile Thr Arg Ile Gln Asn Gln Tyr Leu His Leu Phe 
465                 470                 475                 480 


Gln Asn Leu Asn Thr Arg Val Asn Asn Leu His His Arg Val Thr Tyr 
                485                 490                 495     


Leu Glu Phe Arg Ala Glu Val His Glu Val Gln Thr Gly Leu Gly Cys 
            500                 505                 510         


Val Pro Arg Gly Arg Tyr Cys His Phe Asp Trp Arg Pro Glu Glu Val 
        515                 520                 525             


Gly Leu Asn Met Thr Leu Trp Asn Ser Ser Thr Trp Gln Gln Trp Met 
    530                 535                 540                 


Ser Gln Tyr Asp Gln Ile Glu Glu Asn Ile Trp Asn Leu Lys Tyr Asn 
545                 550                 555                 560 


Trp Ser Glu Ala Leu Glu Lys Gly Lys Ser Asn Thr Asp Gly Leu Glu 
                565                 570                 575     


Pro Asp Val Phe Arg Tyr Leu Ala Asp Leu Ser Ser Ser Phe Thr Trp 
            580                 585                 590         


Gly Ser Trp Val Asp Lys Leu Val Trp Leu Ala Tyr Ile Leu Leu Ala 
        595                 600                 605             


Tyr Phe Ala Phe Lys Val Leu Gln Cys Ile Met Ser Asn Leu Gly Ala 
    610                 615                 620                 


Gln Thr Arg Tyr Gln Leu Leu Asn Ala Gln Glu Asp Thr Asp Pro Ala 
625                 630                 635                 640 


Glu Asp Gly Asp Gln Pro Asp Asp His Arg Ser Gly Asp Thr Pro Arg 
                645                 650                 655     


Ser Gly Val Pro Ser Gly Gly Trp Ser Gln Arg Leu Ser Glu Gly Lys 
            660                 665                 670         


Arg Ile Gly Cys Leu Ile Leu Arg Thr Glu Trp Gln Asn Trp Arg Asn 
        675                 680                 685             


Asp Leu Arg Thr Leu Arg Trp Leu Thr Leu Gly Gly Lys Ile Leu Gln 
    690                 695                 700                 


Leu Pro Leu Ser Leu Leu Val Leu Leu Val Arg Ile Leu Leu Tyr Ile 
705                 710                 715                 720 


Leu Ser Pro Thr Phe Gln Asn Gln Arg Gly Trp Thr Val Gly Arg Lys 
                725                 730                 735     


Gly Thr Gly Gly Asp Asp Arg Glu Leu Ser Pro Glu Leu Glu Tyr Pro 
            740                 745                 750         


Ser Trp Thr Gly Ser Ser Gln Glu Met Met Glu Met Arg Asp Leu Lys 
        755                 760                 765             


Glu Glu Asp Ile Pro Glu Glu Gly Ile Arg Pro Val Glu Met 
    770                 775                 780         


<210>  424
<211>  9
<212>  PRT
<213>  Artificial sequence

<220>
<223>  Mutated sequence


<220>
<221>  MISC_FEATURE
<222>  (3)..(7)
<223>  Xaa is any naturally occurring amino acid or is mutated

<400>  424

Tyr Leu Xaa Xaa Xaa Xaa Xaa Val His 
1               5                   


<210>  425
<211>  14
<212>  PRT
<213>  Artificial sequence

<220>
<223>  Mutated sequence


<220>
<221>  misc_feature
<222>  (5)..(9)
<223>  Xaa is any naturally occurring amino acid or is mutated

<220>
<221>  misc_feature
<222>  (13)..(13)
<223>  Xaa is Leu or Val

<400>  425

Val Thr Tyr Leu Xaa Xaa Xaa Xaa Xaa Val His Glu Xaa Gln 
1               5                   10                  


<210>  426
<211>  859
<212>  PRT
<213>  Artificial sequence

<220>
<223>  Mutated sequence

<400>  426

Met Val Ser Ile Ala Phe Tyr Gly Gly Ile Pro Gly Gly Ile Ser Thr 
1               5                   10                  15      


Pro Ile Thr Gln Gln Ser Glu Lys Ser Lys Cys Glu Glu Asn Thr Met 
            20                  25                  30          


Phe Gln Pro Tyr Cys Tyr Asn Asn Asp Ser Lys Asn Ser Met Ala Glu 
        35                  40                  45              


Ser Lys Glu Ala Arg Asp Gln Glu Met Asn Leu Lys Glu Glu Ser Lys 
    50                  55                  60                  


Glu Glu Lys Arg Arg Asn Asp Trp Trp Lys Ile Gly Met Phe Leu Leu 
65                  70                  75                  80  


Cys Leu Ala Gly Thr Thr Gly Gly Ile Leu Trp Trp Tyr Glu Gly Leu 
                85                  90                  95      


Pro Gln Gln His Tyr Ile Gly Leu Val Ala Ile Gly Gly Arg Leu Asn 
            100                 105                 110         


Gly Ser Gly Gln Ser Asn Ala Ile Glu Cys Trp Gly Ser Phe Pro Gly 
        115                 120                 125             


Cys Arg Pro Phe Gln Asn Tyr Phe Ser Tyr Glu Thr Asn Arg Ser Met 
    130                 135                 140                 


His Met Asp Asn Asn Thr Ala Thr Leu Leu Glu Ala Tyr His Arg Glu 
145                 150                 155                 160 


Ile Thr Phe Ile Tyr Lys Ser Ser Cys Thr Asp Ser Asp His Cys Gln 
                165                 170                 175     


Glu Tyr Gln Cys Lys Lys Val Asn Leu Asn Ser Ser Asp Ser Ser Asn 
            180                 185                 190         


Ser Val Arg Val Glu Asp Val Met Asn Thr Ala Glu Tyr Trp Gly Phe 
        195                 200                 205             


Lys Trp Leu Glu Cys Asn Gln Thr Glu Asn Phe Lys Thr Ile Leu Val 
    210                 215                 220                 


Pro Glu Asn Glu Met Val Asn Ile Asn Asp Thr Asp Thr Trp Ile Pro 
225                 230                 235                 240 


Lys Gly Cys Asn Glu Thr Trp Ala Arg Val Lys Arg Cys Pro Ile Asp 
                245                 250                 255     


Ile Leu Tyr Gly Ile His Pro Ile Arg Leu Cys Val Gln Pro Pro Phe 
            260                 265                 270         


Phe Leu Val Gln Glu Lys Gly Ile Ala Asp Thr Ser Arg Ile Gly Asn 
        275                 280                 285             


Cys Gly Pro Thr Ile Phe Leu Gly Val Leu Glu Asp Asn Lys Gly Val 
    290                 295                 300                 


Val Arg Gly Asp Tyr Thr Ala Cys Asn Val Arg Arg Leu Asn Ile Asn 
305                 310                 315                 320 


Arg Lys Asp Tyr Thr Gly Ile Tyr Gln Val Pro Ile Phe Tyr Thr Cys 
                325                 330                 335     


Thr Phe Thr Asn Ile Thr Ser Cys Asn Asn Glu Pro Ile Ile Ser Val 
            340                 345                 350         


Ile Met Tyr Glu Thr Asn Gln Val Gln Tyr Leu Leu Cys Asn Asn Asn 
        355                 360                 365             


Asn Ser Asn Asn Tyr Asn Cys Val Val Gln Ser Phe Gly Val Ile Gly 
    370                 375                 380                 


Gln Ala His Leu Glu Leu Pro Arg Pro Asn Lys Arg Ile Arg Asn Gln 
385                 390                 395                 400 


Ser Phe Asn Gln Tyr Asn Cys Ser Ile Asn Asn Lys Thr Glu Leu Glu 
                405                 410                 415     


Thr Trp Lys Leu Val Lys Thr Ser Gly Ile Thr Pro Leu Pro Ile Ser 
            420                 425                 430         


Ser Glu Ala Asn Thr Gly Leu Ile Arg His Lys Arg Asp Phe Gly Ile 
        435                 440                 445             


Ser Ala Ile Val Ala Ala Ile Val Ala Ala Thr Ala Ile Ala Ala Ser 
    450                 455                 460                 


Ala Thr Met Ser Tyr Val Ala Leu Thr Glu Val Asn Lys Ile Met Glu 
465                 470                 475                 480 


Val Gln Asn His Thr Phe Glu Val Glu Asn Ser Thr Leu Asn Gly Met 
                485                 490                 495     


Asp Leu Ile Glu Arg Gln Ile Lys Ile Leu Tyr Ala Met Ile Leu Gln 
            500                 505                 510         


Thr His Ala Asp Val Gln Leu Leu Lys Glu Arg Gln Gln Val Glu Glu 
        515                 520                 525             


Thr Phe Asn Leu Ile Gly Cys Ile Glu Arg Thr His Val Phe Cys His 
    530                 535                 540                 


Thr Gly His Pro Trp Asn Met Ser Trp Gly His Leu Asn Glu Ser Thr 
545                 550                 555                 560 


Gln Trp Asp Asp Trp Val Ser Lys Met Glu Asp Leu Asn Gln Glu Ile 
                565                 570                 575     


Leu Thr Thr Leu His Gly Ala Arg Asn Asn Leu Ala Gln Ser Met Ile 
            580                 585                 590         


Thr Phe Asn Thr Pro Asp Ser Ile Ala Gln Phe Gly Lys Asp Leu Trp 
        595                 600                 605             


Ser His Ile Gly Asn Trp Ile Pro Gly Leu Gly Ala Ser Ile Ile Lys 
    610                 615                 620                 


Tyr Ile Val Met Phe Leu Leu Ile Tyr Leu Leu Leu Thr Ser Ser Pro 
625                 630                 635                 640 


Lys Ile Leu Arg Ala Leu Trp Lys Val Thr Ser Gly Ala Gly Ser Ser 
                645                 650                 655     


Gly Ser Arg Tyr Leu Lys Lys Lys Phe His His Lys His Ala Ser Arg 
            660                 665                 670         


Glu Asp Thr Trp Asp Gln Ala Gln His Asn Ile His Leu Ala Gly Val 
        675                 680                 685             


Thr Gly Gly Ser Gly Asp Lys Tyr Tyr Lys Gln Lys Tyr Ser Arg Asn 
    690                 695                 700                 


Asp Trp Asn Gly Glu Ser Glu Glu Tyr Asn Arg Arg Pro Lys Ser Trp 
705                 710                 715                 720 


Val Lys Ser Ile Glu Ala Phe Gly Glu Ser Tyr Ile Ser Glu Lys Thr 
                725                 730                 735     


Lys Gly Glu Ile Ser Gln Pro Gly Ala Ala Ile Asn Glu His Lys Asn 
            740                 745                 750         


Gly Ser Gly Gly Asn Asn Pro His Gln Gly Ser Leu Asp Leu Glu Ile 
        755                 760                 765             


Arg Ser Glu Gly Gly Asn Ile Tyr Asp Cys Cys Ile Lys Ala Gln Glu 
    770                 775                 780                 


Gly Thr Leu Ala Ile Pro Cys Cys Gly Phe Pro Leu Trp Leu Phe Trp 
785                 790                 795                 800 


Gly Leu Val Ile Ile Val Gly Arg Ile Ala Gly Tyr Gly Leu Arg Gly 
                805                 810                 815     


Leu Ala Val Ile Ile Arg Ile Cys Ile Arg Gly Leu Asn Leu Ile Phe 
            820                 825                 830         


Glu Ile Ile Arg Lys Met Leu Asp Tyr Ile Gly Arg Ala Leu Asn Pro 
        835                 840                 845             


Gly Thr Ser His Val Ser Met Pro Gln Tyr Val 
    850                 855                 


<210>  427
<211>  9
<212>  PRT
<213>  Artificial sequence

<220>
<223>  Mutated sequence


<220>
<221>  MISC_FEATURE
<222>  (3)..(7)
<223>  Xaa is any naturally occurring amino acid or is mutated

<220>
<221>  MISC_FEATURE
<222>  (8)..(8)
<223>  Xaa is Val or Ile

<400>  427

Leu Leu Xaa Xaa Xaa Xaa Xaa Xaa Glu 
1               5                   


<210>  428
<211>  14
<212>  PRT
<213>  Artificial sequence

<220>
<223>  Mutated sequence


<220>
<221>  MISC_FEATURE
<222>  (2)..(2)
<223>  Xaa is Gln or Arg

<220>
<221>  MISC_FEATURE
<222>  (5)..(9)
<223>  Xaa is any naturally occurring amino acid or is mutated

<220>
<221>  MISC_FEATURE
<222>  (10)..(10)
<223>  Xaa is Val or Ile

<400>  428

Val Xaa Leu Leu Xaa Xaa Xaa Xaa Xaa Xaa Glu Glu Thr Phe 
1               5                   10                  


<210>  429
<211>  944
<212>  PRT
<213>  Artificial sequence

<220>
<223>  Mutated sequence

<400>  429

Met Asp Ala Gly Ala Arg Tyr Met Arg Leu Thr Gly Lys Glu Asn Trp 
1               5                   10                  15      


Val Glu Val Thr Met Asp Gly Glu Lys Glu Arg Lys Arg Glu Gly Phe 
            20                  25                  30          


Thr Ala Gly Gln Gln Gly Lys Tyr Gln Pro Gln Val Ser Lys Gln Ile 
        35                  40                  45              


Gly Asn Arg Asn Thr Asn Pro Cys Phe Ala Tyr Lys Gly Ile Phe Leu 
    50                  55                  60                  


Trp Arg Ile Ser Leu Thr Met Trp Ile Leu Leu Gly Ile Asn Met Cys 
65                  70                  75                  80  


Val Ser Ala Glu Asp Tyr Ile Thr Leu Ile Ser Asp Pro Tyr Gly Phe 
                85                  90                  95      


Ser Pro Ile Lys Asn Val Ser Gly Val Pro Val Thr Cys Val Thr Lys 
            100                 105                 110         


Glu Phe Ala Lys Trp Gly Cys Gln Pro Leu Gly Ala Tyr Pro Asp Pro 
        115                 120                 125             


Glu Ile Glu Tyr Arg Asn Val Ser Gln Glu Val Val Lys Glu Val Tyr 
    130                 135                 140                 


Gln Glu Asn Trp Pro Trp Asn Thr Tyr His Trp Pro Leu Trp Gln Met 
145                 150                 155                 160 


Glu Asn Val Arg Tyr Trp Leu Lys Glu Asn Met Gln Glu Asn Gln Gln 
                165                 170                 175     


Arg Lys Asn Asn Thr Lys Glu Gly Ile Glu Glu Leu Leu Ala Gly Thr 
            180                 185                 190         


Ile Arg Gly Arg Phe Cys Val Pro Tyr Pro Phe Ala Leu Leu Lys Cys 
        195                 200                 205             


Thr Lys Trp Cys Trp Tyr Thr Ala Ala Ile Asn Asn Glu Ser Gly Lys 
    210                 215                 220                 


Ala Gly Lys Ile Lys Ile Asn Cys Thr Glu Ala Arg Ala Val Ser Cys 
225                 230                 235                 240 


Thr Glu Asp Met Pro Leu Ala Ser Ile Gln Arg Ala Tyr Trp Asp Glu 
                245                 250                 255     


Lys Asp Arg Glu Ser Met Ala Phe Met Asn Ile Lys Ala Cys Asp Ser 
            260                 265                 270         


Asn Leu Arg Cys Gln Lys Arg Pro Gly Gly Cys Met Glu Gly Tyr Pro 
        275                 280                 285             


Ile Pro Val Gly Ala Glu Ile Ile Pro Glu Ser Met Lys Tyr Leu Arg 
    290                 295                 300                 


Gly Ala Lys Ser Gln Tyr Gly Gly Ile Lys Asp Lys Asn Gly Glu Leu 
305                 310                 315                 320 


Lys Leu Pro Leu Thr Leu Arg Val Trp Val Lys Leu Ala Asn Val Ser 
                325                 330                 335     


Glu Trp Val Asn Gly Thr Pro Pro Asp Trp Gln Asp Arg Ile Asn Gly 
            340                 345                 350         


Ser Lys Gly Ile Asn Gly Thr Leu Trp Gly Glu Leu Asn Ser Met His 
        355                 360                 365             


His Leu Gly Phe Ala Leu Ser Gln Asn Gly Lys Trp Cys Asn Tyr Thr 
    370                 375                 380                 


Gly Glu Ile Lys Leu Gly Gln Glu Thr Phe Gln Tyr His Tyr Lys Pro 
385                 390                 395                 400 


Asn Trp Asn Cys Thr Gly Asn Trp Thr Gln Tyr Pro Val Trp Gln Val 
                405                 410                 415     


Ile Arg Asn Leu Asp Met Val Glu His Met Thr Gly Glu Cys Val Gln 
            420                 425                 430         


Arg Pro Gln Arg His Asn Ile Thr Val Gly Asn Gly Thr Ile Thr Gly 
        435                 440                 445             


Asn Cys Ser Thr Thr Asn Trp Asp Gly Cys Asn Cys Ser Arg Ser Gly 
    450                 455                 460                 


Asn Tyr Leu Tyr Asn Ser Ser Glu Gly Gly Leu Leu Leu Ile Leu Cys 
465                 470                 475                 480 


Arg Gln Asn Ser Thr Leu Thr Arg Ile Leu Gly Thr Asn Thr Asn Trp 
                485                 490                 495     


Thr Thr Met Trp Gly Ile Tyr Lys Asn Cys Ser Gly Cys Glu Asn Ala 
            500                 505                 510         


Thr Leu Asp Asn Thr Gly Glu Gly Thr Leu Gly Gly Val Ala Asn Lys 
        515                 520                 525             


Asn Cys Ser Leu Pro His Lys Asn Glu Ser Asn Lys Trp Thr Cys Ala 
    530                 535                 540                 


Pro Arg Gln Arg Asp Gly Lys Thr Asp Ser Leu Tyr Ile Ala Gly Gly 
545                 550                 555                 560 


Lys Lys Phe Trp Thr Arg Ile Lys Ala Gln Phe Ser Cys Glu Ser Asn 
                565                 570                 575     


Ile Gly Gln Leu Asp Gly Met Leu His Gln Gln Ile Leu Leu Gln Lys 
            580                 585                 590         


Tyr Gln Val Ile Lys Val Arg Ala Tyr Thr Tyr Gly Val Ile Glu Met 
        595                 600                 605             


Pro Glu Asn Tyr Ala Lys Thr Arg Ile Ile Asn Arg Lys Lys Arg Glu 
    610                 615                 620                 


Leu Ser His Lys Arg Lys Lys Arg Gly Val Gly Leu Val Ile Met Leu 
625                 630                 635                 640 


Val Ile Met Ala Ile Val Ala Ala Ala Gly Ala Ser Leu Gly Val Ala 
                645                 650                 655     


Asn Ala Ile Gln Gln Ser Tyr Thr Lys Ala Ala Val Gln Thr Leu Ala 
            660                 665                 670         


Asn Ala Thr Ala Ala Gln Gln Asp Val Leu Glu Ala Thr Tyr Ala Met 
        675                 680                 685             


Val Gln His Val Ala Lys Gly Val Arg Ile Leu Glu Ala Arg Val Ala 
    690                 695                 700                 


Arg Val Glu Ala Arg Thr Asp Arg Ile Met Leu Tyr Gln Glu Leu Asp 
705                 710                 715                 720 


Cys Trp His Tyr His Gln Tyr Cys Ile Thr Ser Thr Lys Thr Glu Val 
                725                 730                 735     


Ala Lys Tyr Ile Asn Trp Thr Arg Phe Lys Asp Asn Cys Thr Trp Gln 
            740                 745                 750         


Gln Trp Glu Arg Gly Leu Gln Gly Tyr Asp Thr Asn Leu Thr Ile Leu 
        755                 760                 765             


Leu Lys Glu Ser Ala Ala Met Thr Gln Leu Ala Glu Glu Gln Ala Arg 
    770                 775                 780                 


Arg Ile Pro Glu Val Trp Glu Ser Leu Lys Asp Val Phe Asp Trp Ser 
785                 790                 795                 800 


Gly Trp Phe Ser Trp Leu Lys Tyr Ile Pro Ile Ile Val Val Gly Leu 
                805                 810                 815     


Leu Gly Cys Ile Leu Ile Arg Ala Val Ile Cys Val Cys Gln Pro Leu 
            820                 825                 830         


Val Gln Ile Tyr Arg Thr Leu Ser Thr Pro Thr Tyr Gln Arg Val Thr 
        835                 840                 845             


Val Ile Met Glu Thr Arg Ala Asp Val Ala Gly Glu Asn Gln Asp Phe 
    850                 855                 860                 


Gly Asp Gly Leu Glu Glu Ser Asp Asn Ser Glu Thr Ser Glu Arg Val 
865                 870                 875                 880 


Thr Val Gln Lys Ala Trp Ser Arg Ala Trp Glu Leu Trp Gln Asn Ser 
                885                 890                 895     


Pro Trp Lys Glu Pro Trp Lys Arg Gly Leu Leu Arg Leu Leu Val Leu 
            900                 905                 910         


Pro Leu Thr Met Gly Ile Trp Ile Asn Gly Trp Leu Gly Glu His His 
        915                 920                 925             


Lys Asn Lys Lys Arg Lys Gly Asp Cys Glu Thr Trp Ala Lys Glu Asp 
    930                 935                 940                 


<210>  430
<211>  983
<212>  PRT
<213>  Artificial sequence

<220>
<223>  Mutated sequence

<400>  430

Met Ala Ser Lys Glu Ser Lys Pro Ser Arg Thr Thr Arg Arg Gly Met 
1               5                   10                  15      


Glu Pro Pro Leu Arg Glu Thr Trp Asn Gln Val Leu Gln Glu Leu Val 
            20                  25                  30          


Lys Arg Gln Gln Gln Glu Glu Glu Glu Gln Gln Gly Leu Val Ser Gly 
        35                  40                  45              


Lys Lys Lys Ser Trp Val Ser Ile Asp Leu Leu Gly Thr Glu Gly Lys 
    50                  55                  60                  


Asp Ile Lys Lys Val Asn Ile Trp Glu Pro Cys Glu Lys Trp Phe Ala 
65                  70                  75                  80  


Gln Val Val Trp Gly Val Leu Trp Val Leu Gln Ile Val Leu Trp Gly 
                85                  90                  95      


Cys Leu Met Trp Glu Val Arg Lys Gly Asn Gln Cys Gln Ala Glu Glu 
            100                 105                 110         


Val Ile Ala Leu Val Ser Asp Pro Gly Gly Phe Gln Arg Val Gln His 
        115                 120                 125             


Val Glu Thr Val Pro Val Thr Cys Val Thr Lys Asn Phe Thr Gln Trp 
    130                 135                 140                 


Gly Cys Gln Pro Glu Gly Ala Tyr Pro Asp Pro Glu Leu Glu Tyr Arg 
145                 150                 155                 160 


Asn Ile Ser Arg Glu Ile Leu Glu Glu Val Tyr Lys Gln Asp Trp Pro 
                165                 170                 175     


Trp Asn Thr Tyr His Trp Pro Leu Trp Gln Met Glu Asn Met Arg Gln 
            180                 185                 190         


Trp Met Lys Glu Asn Glu Lys Glu Tyr Lys Glu Arg Thr Asn Lys Thr 
        195                 200                 205             


Lys Glu Asp Ile Asp Asp Leu Val Ala Gly Arg Ile Arg Gly Arg Phe 
    210                 215                 220                 


Cys Val Pro Tyr Pro Tyr Ala Leu Leu Arg Cys Glu Glu Trp Cys Trp 
225                 230                 235                 240 


Tyr Pro Glu Ser Ile Asn Gln Glu Thr Gly His Ala Glu Lys Ile Lys 
                245                 250                 255     


Ile Asn Cys Thr Lys Ala Lys Ala Val Ser Cys Thr Glu Lys Met Ser 
            260                 265                 270         


Leu Ala Ala Val Gln Arg Val Tyr Trp Glu Lys Glu Asp Glu Glu Ser 
        275                 280                 285             


Met Lys Phe Leu Asn Ile Lys Ala Cys Asn Ile Ser Leu Arg Cys Gln 
    290                 295                 300                 


Asp Glu Gly Lys Ser Pro Gly Gly Cys Val Gln Gly Tyr Pro Ile Pro 
305                 310                 315                 320 


Lys Gly Ala Glu Ile Ile Pro Glu Ala Met Lys Tyr Leu Arg Gly Lys 
                325                 330                 335     


Lys Ser Arg Tyr Gly Gly Ile Lys Asp Lys Asn Gly Glu Leu Lys Leu 
            340                 345                 350         


Pro Leu Ser Val Arg Val Trp Val Arg Met Ala Asn Leu Ser Gly Trp 
        355                 360                 365             


Val Asn Gly Thr Pro Pro Tyr Trp Ser Ala Arg Ile Asn Gly Ser Thr 
    370                 375                 380                 


Gly Ile Asn Gly Thr Arg Trp Tyr Gly Ile Gly Thr Leu His His Leu 
385                 390                 395                 400 


Gly Cys Asn Ile Ser Ser Asn Pro Glu Arg Gly Ile Cys Asn Phe Thr 
                405                 410                 415     


Gly Glu Leu Trp Ile Gly Gly Asp Lys Phe Pro Tyr Tyr Tyr Thr Pro 
            420                 425                 430         


Ser Trp Asn Cys Ser Gln Asn Trp Thr Gly His Pro Val Trp His Val 
        435                 440                 445             


Phe Arg Tyr Leu Asp Met Thr Glu His Met Thr Ser Arg Cys Ile Gln 
    450                 455                 460                 


Arg Pro Lys Arg His Asn Ile Thr Val Gly Asn Gly Thr Ile Thr Gly 
465                 470                 475                 480 


Asn Cys Ser Val Thr Asn Trp Asp Gly Cys Asn Cys Thr Arg Ser Gly 
                485                 490                 495     


Asn His Leu Tyr Asn Ser Thr Ser Gly Gly Leu Leu Val Ile Ile Cys 
            500                 505                 510         


Arg Gln Asn Ser Thr Ile Thr Gly Ile Met Gly Thr Asn Thr Asn Trp 
        515                 520                 525             


Thr Thr Met Trp Asn Ile Tyr Gln Asn Cys Ser Arg Cys Asn Asn Ser 
    530                 535                 540                 


Ser Leu Asp Arg Thr Gly Ser Gly Thr Leu Gly Thr Val Asn Asn Leu 
545                 550                 555                 560 


Lys Cys Ser Leu Pro His Arg Asn Glu Ser Asn Lys Trp Thr Cys Lys 
                565                 570                 575     


Ser Gln Arg Asp Ser Tyr Ile Ala Gly Arg Asp Phe Trp Gly Lys Val 
            580                 585                 590         


Lys Ala Lys Tyr Ser Cys Glu Ser Asn Leu Gly Gly Leu Asp Ser Met 
        595                 600                 605             


Met His Gln Gln Met Leu Leu Gln Arg Tyr Gln Val Ile Arg Val Arg 
    610                 615                 620                 


Ala Tyr Thr Tyr Gly Val Val Glu Met Pro Gln Ser Tyr Met Glu Ala 
625                 630                 635                 640 


Gln Gly Glu Asn Lys Arg Ser Arg Arg Asn Leu Gln Arg Lys Lys Arg 
                645                 650                 655     


Gly Ile Gly Leu Val Ile Val Leu Ala Ile Met Ala Ile Ile Ala Ala 
            660                 665                 670         


Ala Gly Ala Gly Leu Gly Val Ala Asn Ala Val Gln Gln Ser Tyr Thr 
        675                 680                 685             


Arg Thr Ala Val Gln Ser Leu Ala Asn Ala Thr Ala Ala Gln Gln Glu 
    690                 695                 700                 


Val Leu Glu Ala Ser Tyr Ala Met Val Gln His Ile Ala Lys Gly Ile 
705                 710                 715                 720 


Arg Ile Leu Glu Ala Arg Val Ala Arg Val Glu Ala Arg Val Asp Arg 
                725                 730                 735     


Met Met Val Tyr Gln Glu Leu Asp Cys Trp His Tyr Gln His Tyr Cys 
            740                 745                 750         


Val Thr Ser Thr Arg Ser Glu Val Ala Asn Tyr Val Asn Trp Thr Arg 
        755                 760                 765             


Phe Lys Asp Asn Cys Thr Trp Gln Gln Trp Glu Glu Glu Ile Glu Gln 
    770                 775                 780                 


His Glu Gly Asn Leu Ser Leu Leu Leu Arg Glu Ala Ala Leu Gln Val 
785                 790                 795                 800 


His Ile Ala Gln Arg Asp Ala Arg Arg Ile Pro Asp Ala Trp Lys Ala 
                805                 810                 815     


Ile Gln Glu Ala Phe Asn Trp Ser Ser Trp Phe Ser Trp Leu Lys Tyr 
            820                 825                 830         


Ile Pro Trp Ile Ile Met Gly Ile Val Gly Leu Met Cys Phe Arg Ile 
        835                 840                 845             


Leu Met Cys Val Ile Ser Met Cys Leu Gln Ala Tyr Lys Gln Val Lys 
    850                 855                 860                 


Gln Ile Arg Tyr Thr Gln Val Thr Val Val Ile Glu Ala Pro Val Glu 
865                 870                 875                 880 


Leu Glu Glu Lys Gln Lys Arg Asn Gly Asp Gly Thr Asn Gly Cys Ala 
                885                 890                 895     


Ser Leu Glu His Glu Arg Arg Thr Ser His Arg Ser Phe Ile Gln Ile 
            900                 905                 910         


Trp Arg Ala Thr Trp Trp Ala Trp Lys Thr Ser Pro Trp Arg His Asn 
        915                 920                 925             


Trp Arg Thr Met Pro Tyr Ile Thr Leu Leu Pro Ile Leu Val Ile Trp 
    930                 935                 940                 


Gln Trp Met Glu Glu Asn Gly Trp Asn Gly Glu Asn Gln His Lys Lys 
945                 950                 955                 960 


Lys Lys Glu Arg Val Asp Cys Gln Asp Arg Glu Gln Met Pro Thr Leu 
                965                 970                 975     


Glu Asn Asp Tyr Val Glu Leu 
            980             


<210>  431
<211>  990
<212>  PRT
<213>  Artificial sequence

<220>
<223>  Mutated sequence

<400>  431

Met Ala Ser Ser Lys Asn Met Pro Ser Arg Ile Thr Gln Lys Ser Met 
1               5                   10                  15      


Glu Pro Pro Leu Arg Glu Thr Trp Gln Gln Val Val Gln Glu Met Val 
            20                  25                  30          


Met Arg Lys Gln Arg Asp Glu Glu Glu Lys Gln Asn Leu Val Thr Gly 
        35                  40                  45              


Lys Glu Lys Ser Trp Val Ser Ile Asp Leu Leu Gly Thr Lys Gln Glu 
    50                  55                  60                  


Gly Lys Arg Gln Lys Val Asn Ile Trp Gly Pro Trp Glu Lys Trp Gly 
65                  70                  75                  80  


Ile Lys Ile Val Trp Val Met Leu Trp Val Ile Gln Leu Met Leu Trp 
                85                  90                  95      


Gly Cys Leu Ile Trp Glu Met Gly Lys Lys His Ser Cys Asn Ala Glu 
            100                 105                 110         


Glu Val Ile Ala Leu Val Asp Asp Pro Gly Gly Phe Gln Lys Val Lys 
        115                 120                 125             


Tyr Val Glu Ser Val Pro Val Thr Cys Met Thr Lys Asn Phe Thr Gln 
    130                 135                 140                 


Trp Gly Cys Gln Pro Glu Gly Ala Tyr Pro Asp Pro Asp Leu Glu Tyr 
145                 150                 155                 160 


Arg Asn Ile Ser Gln Asp Ile Leu Glu Gln Val Tyr Lys Gln Glu Trp 
                165                 170                 175     


Pro Trp Asn Thr Tyr His Trp Pro Leu Trp Gln Met Glu Asn Met Arg 
            180                 185                 190         


Gln Trp Met Lys Glu Asn Glu Lys Glu Tyr Thr Ser Arg Asn Asn Lys 
        195                 200                 205             


Thr Lys Glu Asp Ile Asp Ala Leu Leu Ala Gly Lys Ile Arg Gly Arg 
    210                 215                 220                 


Phe Cys Val Pro Tyr Pro Phe Ala Leu Leu Lys Cys Glu Glu Trp Cys 
225                 230                 235                 240 


Trp Tyr Pro Ala Asn Ile Asn Gln Glu Thr Gly His Ala Gln Gln Ile 
                245                 250                 255     


Lys Ile Asn Cys Thr Lys Ala Lys Ala Val Ser Cys Thr Glu Gln Met 
            260                 265                 270         


Pro Leu Ala Ala Val Gln Arg Val Tyr Trp Glu Lys Glu Asp Glu Glu 
        275                 280                 285             


Gly Met Lys Phe Met Asn Ile Gln Ala Cys Asn Glu Ser Gln Leu Arg 
    290                 295                 300                 


Cys Lys Thr Ser Pro Gly Gly Cys Val Gln Gly Tyr Pro Ile Pro Val 
305                 310                 315                 320 


Gly Ala Glu Ile Ile Pro Glu Ser Met Lys Tyr Leu Arg Gly Lys Lys 
                325                 330                 335     


Ser Pro Tyr Gly Gly Ile Lys Asp Lys Asn Gly Glu Leu Lys Leu Pro 
            340                 345                 350         


Leu Ser Val Arg Val Trp Val Arg Met Ala Asn Leu Ser Gly Trp Val 
        355                 360                 365             


Asn Gly Thr Pro Pro Tyr Trp Ser Ala Arg Ile Lys Gly Ser Thr Gly 
    370                 375                 380                 


Ile Asn Gly Thr Arg Trp Tyr Gly Ile Gly Thr Leu His His Leu Gly 
385                 390                 395                 400 


Tyr Asn Ile Ser Ser Asn Pro Glu Lys Gly Leu Cys Asn Phe Thr Lys 
                405                 410                 415     


Glu Leu Trp Ile Gly Gly Asp Arg Phe Gln Tyr Gln Tyr Lys Pro Ser 
            420                 425                 430         


Trp Asn Cys Ser Gln Asn Trp Thr Gly Tyr Pro Val Trp His Val Phe 
        435                 440                 445             


Arg Tyr Leu Asp Met Thr Glu His Met Thr Ser Arg Cys Val Gln Arg 
    450                 455                 460                 


Pro Leu Arg His Asn Ile Thr Val Gly Asn Gly Thr Ile Thr Gly Asn 
465                 470                 475                 480 


Cys Ser Val Thr Asp Trp Glu Gly Cys Asn Cys Thr Arg Ser Gly Asn 
                485                 490                 495     


Tyr Leu Tyr Asn Ser Thr Thr Gly Gly Leu Leu Val Ile Ile Cys Arg 
            500                 505                 510         


Gln Asn Ser Thr Ile Thr Gly Ile Met Gly Thr Asn Thr Asn Trp Thr 
        515                 520                 525             


Thr Met Trp Gly Ile Tyr Lys Asn Cys Ser Glu Cys Lys Asn Ser Thr 
    530                 535                 540                 


Leu Asp Arg Thr Asp Asn Gly Thr Leu Gly Thr Val Asn Asn Ile Asn 
545                 550                 555                 560 


Cys Ser Leu Pro His Tyr Asn Glu Ser Asn Lys Trp Thr Cys Ala Ala 
                565                 570                 575     


Arg Asn Ser Lys Lys Lys Arg Asp Ser Leu Tyr Ile Ala Gly Arg Asp 
            580                 585                 590         


Phe Trp Gly Arg Val Lys Ala Leu Tyr Ser Cys Glu Ser Asn Leu Gly 
        595                 600                 605             


Gly Leu Asp Gly Met Met His Gln Gln Met Val Leu Gln Lys Tyr Gln 
    610                 615                 620                 


Val Ile Lys Val Arg Ala Tyr Thr Tyr Gly Val Val Asp Met Pro Lys 
625                 630                 635                 640 


Ala Tyr Arg Glu Lys Asn Met Arg Asn Lys Arg Ser Thr Glu Ile Ser 
                645                 650                 655     


Arg Pro Arg Lys Lys Arg Gly Ile Gly Leu Val Ile Val Leu Ala Ile 
            660                 665                 670         


Met Ala Ile Ile Ala Ala Ala Gly Ala Gly Leu Gly Val Ala Asn Ala 
        675                 680                 685             


Val Gln Gln Ser Tyr Thr Arg Thr Ala Val Gln Ser Leu Ala Asn Ala 
    690                 695                 700                 


Thr Ala Ala Gln Gln Asn Val Leu Glu Ala Thr Tyr Ala Met Val Gln 
705                 710                 715                 720 


His Val Ala Lys Gly Val Arg Ile Leu Glu Ala Arg Val Ala Arg Val 
                725                 730                 735     


Glu Ala Arg Val Asp Arg Met Met Leu Tyr His Glu Leu Asp Cys Trp 
            740                 745                 750         


His Tyr Gln His Tyr Cys Val Thr Ser Thr Arg Thr Glu Val Ala Gln 
        755                 760                 765             


Tyr Val Asn Trp Thr Arg Tyr Lys Asp Asn Cys Thr Trp Gln Gln Trp 
    770                 775                 780                 


Glu Glu Glu Ile Glu Gln His Glu Ala Asn Leu Ser Leu Leu Leu Lys 
785                 790                 795                 800 


Glu Ala Ala Leu Gln Val Gln Ile Ala Gln Arg Asp Ala Gln Arg Ile 
                805                 810                 815     


Pro Asp Val Trp Lys Ala Leu Gln Glu Ala Phe Asp Trp Ser Gly Trp 
            820                 825                 830         


Phe Ser Trp Leu Lys Tyr Ile Pro Trp Ile Val Val Cys Ile Val Gly 
        835                 840                 845             


Val Ile Cys Phe Arg Leu Leu Met Cys Val Ile Thr Met Cys Leu Gln 
    850                 855                 860                 


Ala Tyr Arg Gln Val Arg Glu Ile Arg Tyr Thr Arg Val Thr Val Val 
865                 870                 875                 880 


Ile Glu Ala Pro Val Asp Leu Glu Glu Lys Gln Arg Glu Glu Arg Asp 
                885                 890                 895     


Gly Ser Ser Gly Ser Glu Asn Leu Glu His Glu Lys Arg Thr Ser Pro 
            900                 905                 910         


Arg Ser Phe Ile Gln Ile Trp Arg Ala Thr Val Gln Ala Trp Lys Thr 
        915                 920                 925             


Ser Pro Trp Gly Lys Gly Trp Lys Lys Ile Leu Tyr Met Thr Leu Leu 
    930                 935                 940                 


Pro Leu Leu Thr Leu Gln Ile Trp Met Glu Glu Thr Gly Trp Asn Gly 
945                 950                 955                 960 


Asp Lys Arg Cys Lys Lys Lys Lys Glu Arg Val Asp Cys Gln Asp Arg 
                965                 970                 975     


Glu Ser Met Pro Ala Ile Glu Asn Glu Tyr Val Glu Leu Ser 
            980                 985                 990 


<210>  432
<211>  9
<212>  PRT
<213>  Artificial sequence

<220>
<223>  Mutated sequence


<220>
<221>  misc_feature
<222>  (2)..(2)
<223>  Xaa is Val or Met

<220>
<221>  misc_feature
<222>  (3)..(7)
<223>  Xaa is any naturally occurring amino acid or is mutated

<220>
<221>  misc_feature
<222>  (9)..(9)
<223>  Xaa is Met or Ile

<400>  432

Arg Xaa Xaa Xaa Xaa Xaa Xaa Arg Xaa 
1               5                   


<210>  433
<211>  14
<212>  PRT
<213>  Artificial sequence

<220>
<223>  Mutated sequence


<220>
<221>  MISC_FEATURE
<222>  (4)..(4)
<223>  Xaa is Val or Met

<220>
<221>  MISC_FEATURE
<222>  (5)..(9)
<223>  Xaa is any naturally occurring amino acid or is mutated

<220>
<221>  MISC_FEATURE
<222>  (11)..(11)
<223>  Xaa is Met or Ile

<220>
<221>  MISC_FEATURE
<222>  (13)..(13)
<223>  Xaa is Leu or Ile or Val

<400>  433

Val Ala Arg Xaa Xaa Xaa Xaa Xaa Xaa Arg Xaa Met Xaa Tyr 
1               5                   10                  


<210>  434
<211>  16
<212>  PRT
<213>  Artificial sequence

<220>
<223>  Mutated sequence


<220>
<221>  MISC_FEATURE
<222>  (1)..(1)
<223>  Xaa is Thr or Val or Met

<220>
<221>  MISC_FEATURE
<222>  (2)..(2)
<223>  Xaa is Leu or Ile

<220>
<221>  MISC_FEATURE
<222>  (3)..(3)
<223>  Xaa is Ser or Thr or Asn or Gln or Glu  or Asp or Lys or Arg or 
       His or Met or Cys or Trp or Phe or Tyr or Ala or Val or Leu or 
       Ile or Pro or is deleted

<220>
<221>  MISC_FEATURE
<222>  (5)..(5)
<223>  Xaa is Lys or Thr or Arg

<220>
<221>  MISC_FEATURE
<222>  (6)..(6)
<223>  Xaa is Val or Ile

<220>
<221>  MISC_FEATURE
<222>  (7)..(7)
<223>  Xaa is Glu or Arg

<220>
<221>  MISC_FEATURE
<222>  (9)..(9)
<223>  Xaa is Ile or Met or Thr or Leu

<220>
<221>  MISC_FEATURE
<222>  (10)..(14)
<223>  Xaa is any naturally occurring amino acid or is mutated

<400>  434

Xaa Xaa Xaa Leu Xaa Xaa Xaa Ala Xaa Xaa Xaa Xaa Xaa Xaa Thr Ala 
1               5                   10                  15      


<210>  435
<211>  33
<212>  DNA
<213>  Artificial sequence

<220>
<223>  oligonucleotide for introducing mutation within the ISU of 
       lentiviral protein

<400>  435
ataggatcca gaaccatgga gacagacaca ctc                                    33


<210>  436
<211>  32
<212>  DNA
<213>  Artificial sequence

<220>
<223>  oligonucleotide for introducing mutation within the ISU of 
       lentiviral protein

<400>  436
tatgcggccg cttaccttgt ccacaactca ag                                     32


<210>  437
<211>  30
<212>  DNA
<213>  Artificial sequence

<220>
<223>  oligonucleotide for introducing mutation within the ISU of 
       lentiviral protein

<400>  437
atagctgcag cccaagttct ggcaacccat                                        30


<210>  438
<211>  30
<212>  DNA
<213>  Artificial sequence

<220>
<223>  oligonucleotide for introducing mutation within the ISU of 
       lentiviral protein

<400>  438
tataagcttt taccttgtcc acaactcaag                                        30


<210>  439
<211>  39
<212>  DNA
<213>  Artificial sequence

<220>
<223>  oligonucleotide for introducing mutation within the ISU of 
       lentiviral protein

<400>  439
catcaagtac tagtaatagc attaaaagta gaagctatg                              39


<210>  440
<211>  39
<212>  DNA
<213>  Artificial sequence

<220>
<223>  oligonucleotide for introducing mutation within the ISU of 
       lentiviral protein

<400>  440
catagcttct acttttaatg ctattactag tacttgatg                              39


<210>  441
<211>  40
<212>  DNA
<213>  Artificial sequence

<220>
<223>  oligonucleotide for introducing mutation within the ISU of 
       lentiviral protein

<400>  441
gattaaaagt agaagctatg ggaaaatttt tgtatacagc                             40


<210>  442
<211>  40
<212>  DNA
<213>  Artificial sequence

<220>
<223>  oligonucleotide for introducing mutation within the ISU of 
       lentiviral protein

<400>  442
gctgtataca aaaattttcc catagcttct acttttaatc                             40


<210>  443
<211>  40
<212>  DNA
<213>  Artificial sequence

<220>
<223>  oligonucleotide for introducing mutation within the ISU of 
       lentiviral protein

<400>  443
gattaaaagt agaagctatg ttaaaatttt tgtatacagc                             40


<210>  444
<211>  40
<212>  DNA
<213>  Artificial sequence

<220>
<223>  oligonucleotide for introducing mutation within the ISU of 
       lentiviral protein

<400>  444
gctgtataca aaaattttaa catagcttct acttttaatc                             40


<210>  445
<211>  36
<212>  DNA
<213>  Artificial sequence

<220>
<223>  oligonucleotide for introducing mutation within the ISU of 
       lentiviral protein

<400>  445
gtagaagcta tggaaggatt tttgtataca gctttc                                 36


<210>  446
<211>  36
<212>  DNA
<213>  Artificial sequence

<220>
<223>  oligonucleotide for introducing mutation within the ISU of 
       lentiviral protein

<400>  446
gaaagctgta tacaaaaatc cttccatagc ttctac                                 36


<210>  447
<211>  36
<212>  DNA
<213>  Artificial sequence

<220>
<223>  oligonucleotide for introducing mutation within the ISU of 
       lentiviral protein

<400>  447
gtagaagcta tggaattatt tttgtataca gctttc                                 36


<210>  448
<211>  36
<212>  DNA
<213>  Artificial sequence

<220>
<223>  oligonucleotide for introducing mutation within the ISU of 
       lentiviral protein

<400>  448
gaaagctgta tacaaaaata attccatagc ttctac                                 36


<210>  449
<211>  33
<212>  DNA
<213>  Artificial sequence

<220>
<223>  oligonucleotide for introducing mutation within the ISU of 
       lentiviral protein

<400>  449
gaagctatgg aaaaaggatt gtatacagct ttc                                    33


<210>  450
<211>  33
<212>  DNA
<213>  Artificial sequence

<220>
<223>  oligonucleotide for introducing mutation within the ISU of 
       lentiviral protein

<400>  450
gaaagctgta tacaatcctt tttccatagc ttc                                    33


<210>  451
<211>  33
<212>  DNA
<213>  Artificial sequence

<220>
<223>  oligonucleotide for introducing mutation within the ISU of 
       lentiviral protein

<400>  451
gaagctatgg aaaaattatt gtatacagct ttc                                    33


<210>  452
<211>  33
<212>  DNA
<213>  Artificial sequence

<220>
<223>  oligonucleotide for introducing mutation within the ISU of 
       lentiviral protein

<400>  452
gaaagctgta tacaataatt tttccatagc ttc                                    33


<210>  453
<211>  36
<212>  DNA
<213>  Artificial sequence

<220>
<223>  oligonucleotide for introducing mutation within the ISU of 
       lentiviral protein

<400>  453
gctatggaaa aatttggata tacagctttc gctatg                                 36


<210>  454
<211>  36
<212>  DNA
<213>  Artificial sequence

<220>
<223>  oligonucleotide for introducing mutation within the ISU of 
       lentiviral protein

<400>  454
catagcgaaa gctgtatatc caaatttttc catagc                                 36


<210>  455
<211>  36
<212>  DNA
<213>  Artificial sequence

<220>
<223>  oligonucleotide for introducing mutation within the ISU of 
       lentiviral protein

<400>  455
ctatggaaaa atttttggga acagctttcg ctatgc                                 36


<210>  456
<211>  36
<212>  DNA
<213>  Artificial sequence

<220>
<223>  oligonucleotide for introducing mutation within the ISU of 
       lentiviral protein

<400>  456
gcatagcgaa agctgttccc aaaaattttt ccatag                                 36


<210>  457
<211>  36
<212>  DNA
<213>  Artificial sequence

<220>
<223>  oligonucleotide for introducing mutation within the ISU of 
       lentiviral protein

<400>  457
ctatggaaaa atttttgtta acagctttcg ctatgc                                 36


<210>  458
<211>  36
<212>  DNA
<213>  Artificial sequence

<220>
<223>  oligonucleotide for introducing mutation within the ISU of 
       lentiviral protein

<400>  458
gcatagcgaa agctgttaac aaaaattttt ccatag                                 36


<210>  459
<211>  40
<212>  DNA
<213>  Artificial sequence

<220>
<223>  oligonucleotide for introducing mutation within the ISU of 
       lentiviral protein

<400>  459
gattaaaagt agaagctatg tttaaatttt tgtatacagc                             40


<210>  460
<211>  40
<212>  DNA
<213>  Artificial sequence

<220>
<223>  oligonucleotide for introducing mutation within the ISU of 
       lentiviral protein

<400>  460
gctgtataca aaaatttaaa catagcttct acttttaatc                             40


<210>  461
<211>  36
<212>  DNA
<213>  Artificial sequence

<220>
<223>  oligonucleotide for introducing mutation within the ISU of 
       lentiviral protein

<400>  461
gtagaagcta tggaattttt tttgtataca gctttc                                 36


<210>  462
<211>  36
<212>  DNA
<213>  Artificial sequence

<220>
<223>  oligonucleotide for introducing mutation within the ISU of 
       lentiviral protein

<400>  462
gaaagctgta tacaaaaaaa attccatagc ttctac                                 36


<210>  463
<211>  36
<212>  DNA
<213>  Artificial sequence

<220>
<223>  oligonucleotide for introducing mutation within the ISU of 
       lentiviral protein

<400>  463
gctatggaaa aattttttta tacagctttc gctatg                                 36


<210>  464
<211>  36
<212>  DNA
<213>  Artificial sequence

<220>
<223>  oligonucleotide for introducing mutation within the ISU of 
       lentiviral protein

<400>  464
catagcgaaa gctgtataaa aaaatttttc catagc                                 36


<210>  465
<211>  36
<212>  DNA
<213>  Artificial sequence

<220>
<223>  oligonucleotide for introducing mutation within the ISU of 
       lentiviral protein

<400>  465
ctatggaaaa atttttgttt acagctttcg ctatgc                                 36


<210>  466
<211>  36
<212>  DNA
<213>  Artificial sequence

<220>
<223>  oligonucleotide for introducing mutation within the ISU of 
       lentiviral protein

<400>  466
gcatagcgaa agctgtaaac aaaaattttt ccatag                                 36


<210>  467
<211>  16
<212>  PRT
<213>  Artificial sequence

<220>
<223>  Mutated sequence


<220>
<221>  MISC_FEATURE
<222>  (1)..(5)
<223>  Xaa is any naturally occurring amino acid or is mutated

<220>
<221>  MISC_FEATURE
<222>  (6)..(6)
<223>  Xaa is Val or Ile

<220>
<221>  MISC_FEATURE
<222>  (7)..(7)
<223>  Xaa is Glu or Arg

<220>
<221>  MISC_FEATURE
<222>  (9)..(9)
<223>  Xaa is Ile or Met or Thr or Leu

<220>
<221>  MISC_FEATURE
<222>  (12)..(12)
<223>  Xaa is Phe or Pro

<220>
<221>  MISC_FEATURE
<222>  (13)..(13)
<223>  Xaa is Leu or Val or Ile

<400>  467

Xaa Xaa Xaa Xaa Xaa Xaa Xaa Ala Xaa Glu Lys Xaa Xaa Tyr Thr Ala 
1               5                   10                  15      


<210>  468
<211>  16
<212>  PRT
<213>  Artificial sequence

<220>
<223>  Mutated sequence


<220>
<221>  MISC_FEATURE
<222>  (1)..(1)
<223>  Xaa is Thr or Val or Met

<220>
<221>  MISC_FEATURE
<222>  (2)..(2)
<223>  Xaa is Leu or Ile

<220>
<221>  MISC_FEATURE
<222>  (3)..(3)
<223>  Xaa is Ser or Thr or Asn or Gln or Glu or Asp or Lys or Arg or 
       His or Met or Cys or Trp or Phe or Tyr or Ala or Val or Leu or 
       Ile or Pro or is deleted

<220>
<221>  MISC_FEATURE
<222>  (5)..(5)
<223>  Xaa is Lys or Thr or Arg

<220>
<221>  MISC_FEATURE
<222>  (6)..(6)
<223>  Xaa is Val or Ile

<220>
<221>  MISC_FEATURE
<222>  (7)..(7)
<223>  Xaa is Glu or Arg

<220>
<221>  MISC_FEATURE
<222>  (9)..(9)
<223>  Xaa is Ile or Met or Thr or Leu

<220>
<221>  MISC_FEATURE
<222>  (12)..(12)
<223>  Xaa is Phe or Pro

<220>
<221>  MISC_FEATURE
<222>  (13)..(13)
<223>  Xaa is Leu or Val or Ile

<400>  468

Xaa Xaa Xaa Leu Xaa Xaa Xaa Ala Xaa Glu Lys Xaa Xaa Tyr Thr Ala 
1               5                   10                  15      


<210>  469
<211>  72
<212>  PRT
<213>  FIV

<400>  469

Gln Val Leu Ala Thr His Gln Glu Ala Ile Glu Lys Val Thr Glu Ala 
1               5                   10                  15      


Leu Lys Ile Asn Asn Leu Arg Leu Val Thr Leu Glu His Gln Val Leu 
            20                  25                  30          


Val Ile Gly Leu Lys Val Glu Ala Met Glu Lys Phe Leu Tyr Thr Ala 
        35                  40                  45              


Phe Ala Met Gln Glu Leu Gly Cys Asn Gln Asn Gln Phe Phe Cys Lys 
    50                  55                  60                  


Val Pro Pro Val Leu Trp Glu Arg 
65                  70          


<210>  470
<211>  72
<212>  PRT
<213>  FIV

<400>  470

Gln Val Leu Ala Thr His Gln Glu Ala Val Glu Lys Val Thr Glu Ala 
1               5                   10                  15      


Leu Lys Ile Asn Asn Leu Arg Leu Val Thr Leu Glu His Gln Val Leu 
            20                  25                  30          


Val Ile Gly Leu Lys Val Glu Ala Met Glu Lys Phe Leu Tyr Thr Ala 
        35                  40                  45              


Phe Ala Met Gln Glu Leu Gly Cys Asn Gln Asn Gln Phe Phe Cys Lys 
    50                  55                  60                  


Ile Pro Pro Glu Leu Trp Thr Arg 
65                  70          


<210>  471
<211>  72
<212>  PRT
<213>  FIV

<400>  471

Gln Val Leu Ala Thr His Gln Glu Ala Ile Glu Lys Val Thr Glu Ala 
1               5                   10                  15      


Leu Lys Ile Asn Asn Leu Arg Leu Val Thr Leu Glu His Gln Val Leu 
            20                  25                  30          


Val Ile Gly Leu Lys Val Glu Ala Met Glu Lys Phe Leu Tyr Thr Ala 
        35                  40                  45              


Phe Ala Met Gln Glu Leu Gly Cys Asn Gln Asn Gln Phe Phe Cys Lys 
    50                  55                  60                  


Ile Pro Pro Gly Leu Trp Thr Arg 
65                  70          


<210>  472
<211>  72
<212>  PRT
<213>  FIV

<400>  472

Gln Val Leu Ala Thr His Gln Glu Ala Ile Glu Lys Val Thr Gly Ala 
1               5                   10                  15      


Leu Lys Ile Asn Asn Leu Arg Leu Val Thr Leu Glu His Gln Val Leu 
            20                  25                  30          


Val Ile Gly Leu Lys Val Glu Ala Met Glu Lys Phe Leu Tyr Thr Ala 
        35                  40                  45              


Phe Ala Met Gln Glu Leu Gly Cys Asn Gln Asn Gln Phe Phe Cys Lys 
    50                  55                  60                  


Ile Pro Leu Glu Leu Trp Thr Arg 
65                  70          


<210>  473
<211>  72
<212>  PRT
<213>  FIV

<400>  473

Gln Val Leu Ala Thr Gln Gln Glu Ala Ile Glu Lys Val Thr Glu Ala 
1               5                   10                  15      


Leu Lys Ile Thr Asn Leu Arg Leu Val Thr Leu Glu His Gln Val Leu 
            20                  25                  30          


Val Ile Gly Leu Lys Val Glu Ala Met Glu Lys Phe Leu Tyr Thr Ala 
        35                  40                  45              


Phe Ala Met Gln Glu Leu Gly Cys Asn Gln Asn Gln Phe Phe Cys Lys 
    50                  55                  60                  


Val Pro Pro Glu Leu Trp Arg Arg 
65                  70          


<210>  474
<211>  72
<212>  PRT
<213>  FIV

<400>  474

Gln Val Leu Ala Thr His Gln Glu Ala Leu Asp Lys Ile Thr Glu Ala 
1               5                   10                  15      


Leu Lys Ile Asn Asn Leu Arg Leu Val Thr Leu Glu His Gln Val Leu 
            20                  25                  30          


Val Ile Gly Leu Lys Val Glu Ala Thr Glu Lys Phe Leu Tyr Thr Ala 
        35                  40                  45              


Phe Ala Met Gln Glu Leu Gly Cys Asn Gln Asn Gln Phe Phe Cys Lys 
    50                  55                  60                  


Ile Pro Cys Glu Leu Trp Met Arg 
65                  70          


<210>  475
<211>  72
<212>  PRT
<213>  FIV

<400>  475

Gln Val Leu Ala Thr His Gln Gln Ala Leu Asp Lys Ile Thr Glu Ala 
1               5                   10                  15      


Leu Lys Ile Asn Asn Leu Arg Leu Ile Thr Leu Glu His Gln Val Leu 
            20                  25                  30          


Val Ile Gly Leu Lys Val Glu Ala Ile Glu Lys Phe Leu Tyr Thr Ala 
        35                  40                  45              


Phe Ala Met Gln Glu Leu Gly Cys Asn Gln Asn Gln Phe Phe Cys Lys 
    50                  55                  60                  


Ile Pro Pro Ser Leu Trp Ser Met 
65                  70          


<210>  476
<211>  72
<212>  PRT
<213>  FIV

<400>  476

Gln Val Leu Ala Thr His Gln Gln Ala Leu Glu Lys Ile Thr Glu Ala 
1               5                   10                  15      


Leu Lys Ile Asn Asn Leu Arg Leu Ile Thr Leu Glu His Gln Val Leu 
            20                  25                  30          


Val Ile Gly Leu Arg Val Glu Ala Ile Glu Lys Phe Leu Tyr Thr Ala 
        35                  40                  45              


Phe Ala Met Gln Glu Leu Gly Cys Asn Gln Asn Gln Phe Phe Cys Lys 
    50                  55                  60                  


Ile Pro Pro Ser Leu Trp Ser Met 
65                  70          


<210>  477
<211>  72
<212>  PRT
<213>  FIV

<400>  477

Gln Val Leu Ala Thr His Gln Gln Ala Leu Glu Lys Ile Thr Glu Ala 
1               5                   10                  15      


Leu Lys Ile Asn Asn Leu Arg Leu Ile Thr Leu Glu His Gln Val Leu 
            20                  25                  30          


Val Ile Gly Leu Lys Val Glu Ala Ile Glu Lys Phe Leu Tyr Thr Ala 
        35                  40                  45              


Phe Ala Met Gln Glu Leu Gly Cys His Gln Asn Gln Phe Phe Cys Lys 
    50                  55                  60                  


Ile Pro Pro Ser Leu Trp Ser Met 
65                  70          


<210>  478
<211>  72
<212>  PRT
<213>  FIV

<400>  478

Gln Val Leu Ala Thr His Gln His Ala Leu Asp Lys Ile Thr Glu Ala 
1               5                   10                  15      


Leu Lys Ile Asn Asn Leu Arg Leu Ile Thr Leu Val His Gln Val Leu 
            20                  25                  30          


Val Ile Gly Leu Lys Val Arg Ala Ile Glu Lys Pro Leu Tyr Thr Ala 
        35                  40                  45              


Phe Ala Met Gln Glu Leu Gly Cys Asn Gln Asn Gln Phe Phe Cys Lys 
    50                  55                  60                  


Ile Pro Pro Ser Leu Trp Ser Met 
65                  70          


<210>  479
<211>  72
<212>  PRT
<213>  FIV

<400>  479

Gln Val Leu Ala Thr His Gln Gln Ala Leu Asp Lys Ile Thr Gln Ala 
1               5                   10                  15      


Leu Lys Ile Asn Asn Leu Arg Leu Ile Thr Leu Glu His Gln Val Leu 
            20                  25                  30          


Val Ile Gly Leu Lys Val Glu Ala Ile Glu Lys Phe Leu Tyr Thr Ala 
        35                  40                  45              


Phe Ala Met Gln Glu Leu Gly Cys Asn Gln Asn Gln Phe Phe Cys Lys 
    50                  55                  60                  


Ile Pro Pro Ser Leu Trp Ser Met 
65                  70          


<210>  480
<211>  72
<212>  PRT
<213>  FIV

<400>  480

Gln Val Leu Ala Thr His Gln Gln Ala Leu Asp Lys Ile Thr Glu Ala 
1               5                   10                  15      


Leu Lys Ile Asn Asn Leu Arg Leu Ile Thr Leu Glu His Gln Val Leu 
            20                  25                  30          


Val Ile Gly Leu Lys Val Glu Ala Ile Glu Lys Phe Leu Tyr Thr Ala 
        35                  40                  45              


Phe Ala Met Gln Glu Leu Gly Cys Asn Gln Asn Gln Phe Phe Cys Lys 
    50                  55                  60                  


Ile Pro Leu Asn Leu Trp Asn Met 
65                  70          


<210>  481
<211>  72
<212>  PRT
<213>  FIV

<400>  481

Gln Val Leu Ala Thr His Gln Gln Ala Leu Glu Lys Ile Thr Glu Ala 
1               5                   10                  15      


Leu Lys Ile Asn Asn Leu Arg Leu Val Thr Leu Glu His Gln Val Leu 
            20                  25                  30          


Met Ile Gly Leu Lys Val Glu Ala Ile Glu Lys Phe Leu Tyr Thr Ala 
        35                  40                  45              


Phe Ala Met Gln Glu Leu Gly Cys Asn Gln Asn Gln Phe Phe Cys Lys 
    50                  55                  60                  


Ile Pro Leu Asn Leu Trp Thr Met 
65                  70          


<210>  482
<211>  72
<212>  PRT
<213>  FIV

<400>  482

Gln Val Leu Ala Thr His Gln Lys Ala Ile Asp Gln Ile Thr Glu Ala 
1               5                   10                  15      


Leu Lys Ile Asn Asn Leu Arg Leu Val Thr Leu Glu His Gln Val Leu 
            20                  25                  30          


Val Ile Gly Leu Lys Val Glu Ala Ile Glu Lys Phe Ile Tyr Thr Ala 
        35                  40                  45              


Phe Ala Met Gln Glu Leu Gly Cys Asn Gln Asn Gln Phe Phe Cys Lys 
    50                  55                  60                  


Ile Pro Pro Glu Leu Trp Ile Arg 
65                  70          


<210>  483
<211>  72
<212>  PRT
<213>  FIV

<400>  483

Gln Val Leu Ala Thr His Gln Glu Ala Leu Asp Lys Ile Thr Glu Ala 
1               5                   10                  15      


Leu Lys Ile Asn Asn Leu Arg Leu Val Thr Leu Glu His Gln Met Leu 
            20                  25                  30          


Val Ile Gly Leu Lys Val Glu Ala Ile Glu Lys Phe Leu Tyr Thr Ala 
        35                  40                  45              


Phe Ala Met Gln Glu Leu Gly Cys Asn Gln Asn Gln Phe Phe Cys Glu 
    50                  55                  60                  


Ile Pro Lys Glu Leu Trp Leu Arg 
65                  70          


<210>  484
<211>  72
<212>  PRT
<213>  FIV

<400>  484

Gln Val Leu Ala Thr His Gln Glu Ala Ile Glu Lys Val Thr Glu Ala 
1               5                   10                  15      


Leu Lys Ile Asn Asn Leu Arg Leu Val Thr Leu Glu His Gln Val Leu 
            20                  25                  30          


Val Ile Gly Leu Lys Val Glu Ala Met Glu Lys Phe Leu Tyr Thr Ala 
        35                  40                  45              


Phe Ala Met Gln Glu Leu Gly Cys Asn Gln Asn Gln Phe Phe Cys Lys 
    50                  55                  60                  


Val Pro Ser Ala Leu Trp Glu Arg 
65                  70          


<210>  485
<211>  72
<212>  PRT
<213>  FIV

<400>  485

Gln Val Leu Ala Thr His Gln Glu Ala Ile Glu Lys Val Thr Glu Ala 
1               5                   10                  15      


Leu Lys Ile Asn Asn Leu Arg Leu Val Thr Leu Glu His Gln Val Leu 
            20                  25                  30          


Val Ile Gly Leu Lys Val Glu Ala Met Glu Lys Phe Leu Tyr Thr Ala 
        35                  40                  45              


Phe Ala Met Gln Glu Leu Gly Cys Asn Gln Asn Gln Phe Phe Cys Lys 
    50                  55                  60                  


Val Pro Pro Gln Leu Trp Lys Arg 
65                  70          


<210>  486
<211>  72
<212>  PRT
<213>  FIV

<400>  486

Gln Val Leu Ala Thr His Gln Glu Thr Ile Glu Lys Val Thr Glu Ala 
1               5                   10                  15      


Leu Lys Ile Asn Asn Leu Arg Leu Val Thr Leu Glu His Gln Val Leu 
            20                  25                  30          


Val Ile Gly Leu Lys Val Glu Ala Met Glu Lys Phe Leu Tyr Thr Ala 
        35                  40                  45              


Phe Ala Met Gln Glu Leu Gly Cys Asn Gln Asn Gln Phe Phe Cys Lys 
    50                  55                  60                  


Val Pro Pro Glu Leu Trp Lys Arg 
65                  70          


<210>  487
<211>  72
<212>  PRT
<213>  FIV

<400>  487

Gln Val Leu Ala Thr His Gln Glu Ala Ile Glu Lys Val Thr Glu Ala 
1               5                   10                  15      


Leu Lys Val Asn Asn Leu Arg Leu Ile Thr Leu Glu His Gln Val Leu 
            20                  25                  30          


Val Ile Gly Leu Lys Val Glu Ala Met Glu Lys Phe Leu Tyr Thr Ala 
        35                  40                  45              


Phe Ala Met Gln Glu Leu Gly Cys Asn Gln Asn Gln Phe Phe Cys Lys 
    50                  55                  60                  


Val Pro Pro Glu Leu Trp Lys Arg 
65                  70          


<210>  488
<211>  72
<212>  PRT
<213>  FIV

<400>  488

Gln Val Leu Ala Thr His Gln Glu Thr Ile Glu Lys Ile Thr Glu Ala 
1               5                   10                  15      


Leu Lys Val Asn Asn Leu Arg Leu Val Thr Leu Glu His Gln Val Leu 
            20                  25                  30          


Val Ile Gly Leu Lys Val Glu Ala Ile Glu Lys Phe Leu Tyr Thr Ala 
        35                  40                  45              


Phe Ala Met Gln Glu Leu Gly Cys Asn Gln Asn Gln Phe Phe Cys Lys 
    50                  55                  60                  


Val Pro Pro Glu Leu Trp Gln Arg 
65                  70          


<210>  489
<211>  9
<212>  PRT
<213>  Artificial sequence

<220>
<223>  Mutated sequence


<220>
<221>  MISC_FEATURE
<222>  (2)..(2)
<223>  Xaa is Ile or Met or Thr or Leu

<220>
<221>  MISC_FEATURE
<222>  (3)..(3)
<223>  Xaa is Ala or Gly or Arg

<220>
<221>  MISC_FEATURE
<222>  (5)..(5)
<223>  Xaa is Phe or Pro

<220>
<221>  MISC_FEATURE
<222>  (6)..(6)
<223>  Xaa is Leu or Val or Ile

<400>  489

Ala Xaa Xaa Lys Xaa Xaa Tyr Thr Ala 
1               5                   


<210>  490
<211>  9
<212>  PRT
<213>  Artificial sequence

<220>
<223>  Mutated sequence


<220>
<221>  MISC_FEATURE
<222>  (2)..(2)
<223>  Xaa is Ile or Met or Thr or Leu

<220>
<221>  MISC_FEATURE
<222>  (4)..(4)
<223>  Xaa is Ala or Gly or Arg

<220>
<221>  MISC_FEATURE
<222>  (5)..(5)
<223>  Xaa is Phe or Pro

<220>
<221>  MISC_FEATURE
<222>  (6)..(6)
<223>  Xaa is Leu or Val or Ile

<400>  490

Ala Xaa Glu Xaa Xaa Xaa Tyr Thr Ala 
1               5                   


<210>  491
<211>  9
<212>  PRT
<213>  Artificial sequence

<220>
<223>  Mutated sequence


<220>
<221>  MISC_FEATURE
<222>  (2)..(2)
<223>  Xaa is Ile or Met or Thr or Leu

<220>
<221>  MISC_FEATURE
<222>  (5)..(5)
<223>  Xaa is Ala or Gly or Arg

<220>
<221>  MISC_FEATURE
<222>  (6)..(6)
<223>  Xaa is Leu or Val or Ile

<400>  491

Ala Xaa Glu Lys Xaa Xaa Tyr Thr Ala 
1               5                   


<210>  492
<211>  9
<212>  PRT
<213>  Artificial sequence

<220>
<223>  Mutated sequence


<220>
<221>  MISC_FEATURE
<222>  (2)..(2)
<223>  Xaa is Ile or Met or Thr or Leu

<220>
<221>  MISC_FEATURE
<222>  (5)..(5)
<223>  Xaa is Phe or Pro

<220>
<221>  MISC_FEATURE
<222>  (6)..(6)
<223>  Xaa is Ala or Gly or Arg

<400>  492

Ala Xaa Glu Lys Xaa Xaa Tyr Thr Ala 
1               5                   


<210>  493
<211>  9
<212>  PRT
<213>  Artificial sequence

<220>
<223>  Mutated sequence


<220>
<221>  MISC_FEATURE
<222>  (2)..(2)
<223>  Xaa is Ile or Met or Thr or Leu

<220>
<221>  MISC_FEATURE
<222>  (5)..(5)
<223>  Xaa is Phe or Pro

<220>
<221>  MISC_FEATURE
<222>  (6)..(6)
<223>  Xaa is Leu or Val or Ile

<220>
<221>  MISC_FEATURE
<222>  (7)..(7)
<223>  Xaa is Ala or Gly or Arg

<400>  493

Ala Xaa Glu Lys Xaa Xaa Xaa Thr Ala 
1               5                   


<210>  494
<211>  9
<212>  PRT
<213>  Artificial sequence

<220>
<223>  Mutated sequence


<220>
<221>  MISC_FEATURE
<222>  (2)..(2)
<223>  Xaa is Ile or Met or Thr or Leu

<220>
<221>  MISC_FEATURE
<222>  (5)..(5)
<223>  Xaa is Ala or Gly or Arg

<220>
<221>  MISC_FEATURE
<222>  (6)..(6)
<223>  Xaa is Ala or Gly or Arg

<400>  494

Ala Xaa Glu Lys Xaa Xaa Tyr Thr Ala 
1               5                   


<210>  495
<211>  9
<212>  PRT
<213>  Artificial sequence

<220>
<223>  Mutated sequence


<220>
<221>  MISC_FEATURE
<222>  (2)..(2)
<223>  Xaa is Ile or Met or Thr or Leu

<220>
<221>  MISC_FEATURE
<222>  (5)..(5)
<223>  Xaa is Phe or Pro

<220>
<221>  MISC_FEATURE
<222>  (6)..(6)
<223>  Xaa is Leu or Val or Ile

<400>  495

Ala Xaa Glu Gly Xaa Xaa Tyr Thr Ala 
1               5                   


<210>  496
<211>  9
<212>  PRT
<213>  Artificial sequence

<220>
<223>  Mutated sequence


<220>
<221>  MISC_FEATURE
<222>  (2)..(2)
<223>  Xaa is Ile or Met or Thr or Leu

<220>
<221>  MISC_FEATURE
<222>  (5)..(5)
<223>  Xaa is Phe or Pro

<220>
<221>  MISC_FEATURE
<222>  (6)..(6)
<223>  Xaa is Leu or Val or Ile

<400>  496

Ala Xaa Glu Lys Xaa Xaa Gly Thr Ala 
1               5                   


<210>  497
<211>  9
<212>  PRT
<213>  Artificial sequence

<220>
<223>  Mutated sequence


<220>
<221>  MISC_FEATURE
<222>  (2)..(2)
<223>  Xaa is Ile or Met or Thr or Leu

<220>
<221>  MISC_FEATURE
<222>  (5)..(5)
<223>  Xaa is Phe or Pro

<220>
<221>  MISC_FEATURE
<222>  (6)..(6)
<223>  Xaa is Leu or Val or Ile

<400>  497

Ala Xaa Arg Lys Xaa Xaa Tyr Thr Ala 
1               5                   


<210>  498
<211>  9
<212>  PRT
<213>  Artificial sequence

<220>
<223>  Mutated sequence


<220>
<221>  MISC_FEATURE
<222>  (2)..(2)
<223>  Xaa is Ile or Met or Thr or Leu

<220>
<221>  MISC_FEATURE
<222>  (5)..(5)
<223>  Xaa is Phe or Pro

<220>
<221>  MISC_FEATURE
<222>  (6)..(6)
<223>  Xaa is Leu or Val or Ile

<400>  498

Ala Xaa Glu Arg Xaa Xaa Tyr Thr Ala 
1               5                   


<210>  499
<211>  9
<212>  PRT
<213>  Artificial sequence

<220>
<223>  Mutated sequence


<220>
<221>  misc_feature
<222>  (2)..(2)
<223>  Xaa is Ile or Met or Thr or Leu

<220>
<221>  misc_feature
<222>  (6)..(6)
<223>  Xaa is Leu or Val or Ile

<400>  499

Ala Xaa Glu Lys Arg Xaa Tyr Thr Ala 
1               5                   


<210>  500
<211>  9
<212>  PRT
<213>  Artificial sequence

<220>
<223>  Mutated sequence


<220>
<221>  misc_feature
<222>  (2)..(2)
<223>  Xaa is Ile or Met or Thr or Leu

<220>
<221>  misc_feature
<222>  (5)..(5)
<223>  Xaa is Phe or Pro

<400>  500

Ala Xaa Glu Lys Xaa Arg Tyr Thr Ala 
1               5                   


<210>  501
<211>  9
<212>  PRT
<213>  Artificial sequence

<220>
<223>  Mutated sequence


<220>
<221>  MISC_FEATURE
<222>  (2)..(2)
<223>  Xaa is Ile or Met or Thr or Leu

<220>
<221>  MISC_FEATURE
<222>  (5)..(5)
<223>  Xaa is Phe or Pro

<220>
<221>  MISC_FEATURE
<222>  (6)..(6)
<223>  Xaa is Leu or Val or Ile

<400>  501

Ala Xaa Glu Lys Xaa Xaa Arg Thr Ala 
1               5                   


<210>  502
<211>  9
<212>  PRT
<213>  Artificial sequence

<220>
<223>  Mutated sequence


<220>
<221>  MISC_FEATURE
<222>  (2)..(2)
<223>  Xaa is Ile or Met or Thr or Leu

<400>  502

Ala Xaa Glu Lys Arg Arg Tyr Thr Ala 
1               5                   


