                         SEQUENCE LISTING

<110>  INTELECTYS
 
<120>  APOBEC3A as an anti-tumor agent

<130>  B1616PC

<160>  4     

<170>  PatentIn version 3.3

<210>  1
<211>  1444
<212>  DNA
<213>  Homo sapiens


<220>
<221>  CDS
<222>  (171)..(770)

<400>  1
ggagaagggg tggggcaggg tatcgctgac tcagcagctt ccaggttgct ctgatgatat     60

attaaggctc ctgaatccta agagaatgtt ggtgaagatc ttaacaccac gccttgagca    120

agtcgcaaga gcgggaggac acagaccagg aaccgagaag ggacaagcac atg gaa       176
                                                       Met Glu          
                                                       1                

gcc agc cca gca tcc ggg ccc aga cac ttg atg gat cca cac ata ttc      224
Ala Ser Pro Ala Ser Gly Pro Arg His Leu Met Asp Pro His Ile Phe         
        5                   10                  15                      

act tcc aac ttt aac aat ggc att gga agg cat aag acc tac ctg tgc      272
Thr Ser Asn Phe Asn Asn Gly Ile Gly Arg His Lys Thr Tyr Leu Cys         
    20                  25                  30                          

tac gaa gtg gag cgc ctg gac aat ggc acc tcg gtc aag atg gac cag      320
Tyr Glu Val Glu Arg Leu Asp Asn Gly Thr Ser Val Lys Met Asp Gln         
35                  40                  45                  50          

cac agg ggc ttt cta cac aac cag gct aag aat ctt ctc tgt ggc ttt      368
His Arg Gly Phe Leu His Asn Gln Ala Lys Asn Leu Leu Cys Gly Phe         
                55                  60                  65              

tac ggc cgc cat gcg gag ctg cgc ttc ttg gac ctg gtt cct tct ttg      416
Tyr Gly Arg His Ala Glu Leu Arg Phe Leu Asp Leu Val Pro Ser Leu         
            70                  75                  80                  

cag ttg gac ccg gcc cag atc tac agg gtc act tgg ttc atc tcc tgg      464
Gln Leu Asp Pro Ala Gln Ile Tyr Arg Val Thr Trp Phe Ile Ser Trp         
        85                  90                  95                      

agc ccc tgc ttc tcc tgg ggc tgt gcc ggg gaa gtg cgt gcg ttc ctt      512
Ser Pro Cys Phe Ser Trp Gly Cys Ala Gly Glu Val Arg Ala Phe Leu         
    100                 105                 110                         

cag gag aac aca cac gtg aga ctg cgt atc ttc gct gcc cgc atc tat      560
Gln Glu Asn Thr His Val Arg Leu Arg Ile Phe Ala Ala Arg Ile Tyr         
115                 120                 125                 130         

gat tac gac ccc cta tat aag gag gca ctg caa atg ctg cgg gat gct      608
Asp Tyr Asp Pro Leu Tyr Lys Glu Ala Leu Gln Met Leu Arg Asp Ala         
                135                 140                 145             

ggg gcc caa gtc tcc atc atg acc tac gat gaa ttt aag cac tgc tgg      656
Gly Ala Gln Val Ser Ile Met Thr Tyr Asp Glu Phe Lys His Cys Trp         
            150                 155                 160                 

gac acc ttt gtg gac cac cag gga tgt ccc ttc cag ccc tgg gat gga      704
Asp Thr Phe Val Asp His Gln Gly Cys Pro Phe Gln Pro Trp Asp Gly         
        165                 170                 175                     

cta gat gag cac agc caa gcc ctg agt ggg agg ctg cgg gcc att ctc      752
Leu Asp Glu His Ser Gln Ala Leu Ser Gly Arg Leu Arg Ala Ile Leu         
    180                 185                 190                         

cag aat cag gga aac tga aggatgggcc tcagtctcta aggaaggcag             800
Gln Asn Gln Gly Asn                                                     
195                                                                     

agacctgggt tgagcagcag aataaaagat cttcttccaa gaaatgcaaa cagaccgttc    860

accaccatct ccagctgctc acagacgcca gcaaagcagt atgctcccga tcaagtagat    920

ttttaaaaaa tcagagtggg ccgggcgcgg tggctcacgc ctgtaatccc agcactttgg    980

aggccaaggc gggtggatca cgaggtcagg agatcgagac catcctggct aacacggtga   1040

aaccctgtct ctactaaaaa tacaaaaaat tagccaggcg tggtggcggg cgcctgtagt   1100

cccagctact ctggaggctg aggcaggaga gtagcgtgaa cccgggaggc agagcttgcg   1160

gtgagccgag attgcgctac tgcactccag cctgggcgac agtaccagac tccatctcaa   1220

aaaaaaaaaa accagactga attaatttta actgaaaatt tctcttatgt tccaagtaca   1280

caatagtaag attatgctca atattctcag aataattttc aatgtattaa tgaaatgaaa   1340

tgataatttg gcttcatatc tagactaaca caaaattaag aatcttccat aattgctttt   1400

gctcagtaac tgtgtcatga attgcaagag tttccacaaa cact                    1444


<210>  2
<211>  199
<212>  PRT
<213>  Homo sapiens

<400>  2

Met Glu Ala Ser Pro Ala Ser Gly Pro Arg His Leu Met Asp Pro His 
1               5                   10                  15      


Ile Phe Thr Ser Asn Phe Asn Asn Gly Ile Gly Arg His Lys Thr Tyr 
            20                  25                  30          


Leu Cys Tyr Glu Val Glu Arg Leu Asp Asn Gly Thr Ser Val Lys Met 
        35                  40                  45              


Asp Gln His Arg Gly Phe Leu His Asn Gln Ala Lys Asn Leu Leu Cys 
    50                  55                  60                  


Gly Phe Tyr Gly Arg His Ala Glu Leu Arg Phe Leu Asp Leu Val Pro 
65                  70                  75                  80  


Ser Leu Gln Leu Asp Pro Ala Gln Ile Tyr Arg Val Thr Trp Phe Ile 
                85                  90                  95      


Ser Trp Ser Pro Cys Phe Ser Trp Gly Cys Ala Gly Glu Val Arg Ala 
            100                 105                 110         


Phe Leu Gln Glu Asn Thr His Val Arg Leu Arg Ile Phe Ala Ala Arg 
        115                 120                 125             


Ile Tyr Asp Tyr Asp Pro Leu Tyr Lys Glu Ala Leu Gln Met Leu Arg 
    130                 135                 140                 


Asp Ala Gly Ala Gln Val Ser Ile Met Thr Tyr Asp Glu Phe Lys His 
145                 150                 155                 160 


Cys Trp Asp Thr Phe Val Asp His Gln Gly Cys Pro Phe Gln Pro Trp 
                165                 170                 175     


Asp Gly Leu Asp Glu His Ser Gln Ala Leu Ser Gly Arg Leu Arg Ala 
            180                 185                 190         


Ile Leu Gln Asn Gln Gly Asn 
        195                 


<210>  3
<211>  1560
<212>  DNA
<213>  Homo sapiens


<220>
<221>  CDS
<222>  (56)..(1204)

<400>  3
cacagagctt caaaaaaaga gcgggacagg gacaagcgta tctaagaggc tgaac atg      58
                                                             Met        
                                                             1          

aat cca cag atc aga aat ccg atg gag cgg atg tat cga gac aca ttc      106
Asn Pro Gln Ile Arg Asn Pro Met Glu Arg Met Tyr Arg Asp Thr Phe         
            5                   10                  15                  

tac gac aac ttt gaa aac gaa ccc atc ctc tat ggt cgg agc tac act      154
Tyr Asp Asn Phe Glu Asn Glu Pro Ile Leu Tyr Gly Arg Ser Tyr Thr         
        20                  25                  30                      

tgg ctg tgc tat gaa gtg aaa ata aag agg ggc cgc tca aat ctc ctt      202
Trp Leu Cys Tyr Glu Val Lys Ile Lys Arg Gly Arg Ser Asn Leu Leu         
    35                  40                  45                          

tgg gac aca ggg gtc ttt cga ggc cag gtg tat ttc aag cct cag tac      250
Trp Asp Thr Gly Val Phe Arg Gly Gln Val Tyr Phe Lys Pro Gln Tyr         
50                  55                  60                  65          

cac gca gaa atg tgc ttc ctc tct tgg ttc tgt ggc aac cag ctg cct      298
His Ala Glu Met Cys Phe Leu Ser Trp Phe Cys Gly Asn Gln Leu Pro         
                70                  75                  80              

gct tac aag tgt ttc cag atc acc tgg ttt gta tcc tgg acc ccc tgc      346
Ala Tyr Lys Cys Phe Gln Ile Thr Trp Phe Val Ser Trp Thr Pro Cys         
            85                  90                  95                  

ccg gac tgt gtg gcg aag ctg gcc gaa ttc ctg tct gag cac ccc aat      394
Pro Asp Cys Val Ala Lys Leu Ala Glu Phe Leu Ser Glu His Pro Asn         
        100                 105                 110                     

gtc acc ctg acc atc tct gcc gcc cgc ctc tac tac tac tgg gaa aga      442
Val Thr Leu Thr Ile Ser Ala Ala Arg Leu Tyr Tyr Tyr Trp Glu Arg         
    115                 120                 125                         

gat tac cga agg gcg ctc tgc agg ctg agt cag gca gga gcc cgc gtg      490
Asp Tyr Arg Arg Ala Leu Cys Arg Leu Ser Gln Ala Gly Ala Arg Val         
130                 135                 140                 145         

aag atc atg gac tat gaa gaa ttt gca tac tgc tgg gaa aac ttt gtg      538
Lys Ile Met Asp Tyr Glu Glu Phe Ala Tyr Cys Trp Glu Asn Phe Val         
                150                 155                 160             

tac aat gaa ggt cag caa ttc atg cct tgg tac aaa ttc gat gaa aat      586
Tyr Asn Glu Gly Gln Gln Phe Met Pro Trp Tyr Lys Phe Asp Glu Asn         
            165                 170                 175                 

tat gca ttc ctg cac cgc acg cta aag gag att ctc aga tac ctg atg      634
Tyr Ala Phe Leu His Arg Thr Leu Lys Glu Ile Leu Arg Tyr Leu Met         
        180                 185                 190                     

gat cca gac aca ttc act ttc aac ttt aat aat gac cct ttg gtc ctt      682
Asp Pro Asp Thr Phe Thr Phe Asn Phe Asn Asn Asp Pro Leu Val Leu         
    195                 200                 205                         

cga cgg cgc cag acc tac ttg tgc tat gag gtg gag cgc ctg gac aat      730
Arg Arg Arg Gln Thr Tyr Leu Cys Tyr Glu Val Glu Arg Leu Asp Asn         
210                 215                 220                 225         

ggc acc tgg gtc ctg atg gac cag cac atg ggc ttt cta tgc aac gag      778
Gly Thr Trp Val Leu Met Asp Gln His Met Gly Phe Leu Cys Asn Glu         
                230                 235                 240             

gct aag aat ctt ctc tgt ggc ttt tac ggc cgc cat gcg gag ctg cgc      826
Ala Lys Asn Leu Leu Cys Gly Phe Tyr Gly Arg His Ala Glu Leu Arg         
            245                 250                 255                 

ttc ttg gac ctg gtt cct tct ttg cag ttg gac ccg gcc cag atc tac      874
Phe Leu Asp Leu Val Pro Ser Leu Gln Leu Asp Pro Ala Gln Ile Tyr         
        260                 265                 270                     

agg gtc act tgg ttc atc tcc tgg agc ccc tgc ttc tcc tgg ggc tgt      922
Arg Val Thr Trp Phe Ile Ser Trp Ser Pro Cys Phe Ser Trp Gly Cys         
    275                 280                 285                         

gcc ggg gaa gtg cgt gcg ttc ctt cag gag aac aca cac gtg aga ctg      970
Ala Gly Glu Val Arg Ala Phe Leu Gln Glu Asn Thr His Val Arg Leu         
290                 295                 300                 305         

cgc atc ttc gct gcc cgc atc tat gat tac gac ccc cta tat aag gag     1018
Arg Ile Phe Ala Ala Arg Ile Tyr Asp Tyr Asp Pro Leu Tyr Lys Glu         
                310                 315                 320             

gcg ctg caa atg ctg cgg gat gct ggg gcc caa gtc tcc atc atg acc     1066
Ala Leu Gln Met Leu Arg Asp Ala Gly Ala Gln Val Ser Ile Met Thr         
            325                 330                 335                 

tac gat gag ttt gag tac tgc tgg gac acc ttt gtg tac cgc cag gga     1114
Tyr Asp Glu Phe Glu Tyr Cys Trp Asp Thr Phe Val Tyr Arg Gln Gly         
        340                 345                 350                     

tgt ccc ttc cag ccc tgg gat gga cta gag gag cac agc caa gcc ctg     1162
Cys Pro Phe Gln Pro Trp Asp Gly Leu Glu Glu His Ser Gln Ala Leu         
    355                 360                 365                         

agt ggg agg ctg cgg gcc att ctc cag aat cag gga aac tga             1204
Ser Gly Arg Leu Arg Ala Ile Leu Gln Asn Gln Gly Asn                     
370                 375                 380                             

aggatgggcc tcagtctcta aggaaggcag agacctgggt tgagcagcag aataaaagat   1264

cttcttccaa gaaatgcaaa cagaccgttc accaccatct ccagctgctc acagacacca   1324

gcaaagcaat gtgctcctga tcaagtagat tttttaaaaa tcagagtcaa ttaattttaa   1384

ttgaaaattt ctcttatgtt ccaagtgtac aagagtaaga ttatgctcaa tattcccaga   1444

atagttttca atgtattaat gaagtgatta attggctcca tatttagact aataaaacat   1504

taagaatctt ccataattgt ttccacaaac actaaaaaaa aaaaaaaaaa aaaaaa       1560


<210>  4
<211>  382
<212>  PRT
<213>  Homo sapiens

<400>  4

Met Asn Pro Gln Ile Arg Asn Pro Met Glu Arg Met Tyr Arg Asp Thr 
1               5                   10                  15      


Phe Tyr Asp Asn Phe Glu Asn Glu Pro Ile Leu Tyr Gly Arg Ser Tyr 
            20                  25                  30          


Thr Trp Leu Cys Tyr Glu Val Lys Ile Lys Arg Gly Arg Ser Asn Leu 
        35                  40                  45              


Leu Trp Asp Thr Gly Val Phe Arg Gly Gln Val Tyr Phe Lys Pro Gln 
    50                  55                  60                  


Tyr His Ala Glu Met Cys Phe Leu Ser Trp Phe Cys Gly Asn Gln Leu 
65                  70                  75                  80  


Pro Ala Tyr Lys Cys Phe Gln Ile Thr Trp Phe Val Ser Trp Thr Pro 
                85                  90                  95      


Cys Pro Asp Cys Val Ala Lys Leu Ala Glu Phe Leu Ser Glu His Pro 
            100                 105                 110         


Asn Val Thr Leu Thr Ile Ser Ala Ala Arg Leu Tyr Tyr Tyr Trp Glu 
        115                 120                 125             


Arg Asp Tyr Arg Arg Ala Leu Cys Arg Leu Ser Gln Ala Gly Ala Arg 
    130                 135                 140                 


Val Lys Ile Met Asp Tyr Glu Glu Phe Ala Tyr Cys Trp Glu Asn Phe 
145                 150                 155                 160 


Val Tyr Asn Glu Gly Gln Gln Phe Met Pro Trp Tyr Lys Phe Asp Glu 
                165                 170                 175     


Asn Tyr Ala Phe Leu His Arg Thr Leu Lys Glu Ile Leu Arg Tyr Leu 
            180                 185                 190         


Met Asp Pro Asp Thr Phe Thr Phe Asn Phe Asn Asn Asp Pro Leu Val 
        195                 200                 205             


Leu Arg Arg Arg Gln Thr Tyr Leu Cys Tyr Glu Val Glu Arg Leu Asp 
    210                 215                 220                 


Asn Gly Thr Trp Val Leu Met Asp Gln His Met Gly Phe Leu Cys Asn 
225                 230                 235                 240 


Glu Ala Lys Asn Leu Leu Cys Gly Phe Tyr Gly Arg His Ala Glu Leu 
                245                 250                 255     


Arg Phe Leu Asp Leu Val Pro Ser Leu Gln Leu Asp Pro Ala Gln Ile 
            260                 265                 270         


Tyr Arg Val Thr Trp Phe Ile Ser Trp Ser Pro Cys Phe Ser Trp Gly 
        275                 280                 285             


Cys Ala Gly Glu Val Arg Ala Phe Leu Gln Glu Asn Thr His Val Arg 
    290                 295                 300                 


Leu Arg Ile Phe Ala Ala Arg Ile Tyr Asp Tyr Asp Pro Leu Tyr Lys 
305                 310                 315                 320 


Glu Ala Leu Gln Met Leu Arg Asp Ala Gly Ala Gln Val Ser Ile Met 
                325                 330                 335     


Thr Tyr Asp Glu Phe Glu Tyr Cys Trp Asp Thr Phe Val Tyr Arg Gln 
            340                 345                 350         


Gly Cys Pro Phe Gln Pro Trp Asp Gly Leu Glu Glu His Ser Gln Ala 
        355                 360                 365             


Leu Ser Gly Arg Leu Arg Ala Ile Leu Gln Asn Gln Gly Asn 
    370                 375                 380         


