                         SEQUENCE LISTING

<110>  J. Michael McIntosh
 
<120>  CONOTOXIN PEPTIDES, PHARMACEUTICAL COMPOSITIONS AND USES THEREOF

<130>  U008-0002PCT

<150>  61/829,633
<151>  2013-05-31

<150>  61/843,135
<151>  2013-07-05

<160>  22    

<170>  PatentIn version 3.5

<210>  1
<211>  13
<212>  PRT
<213>  Conus regia

<400>  1

Gly Cys Cys Ser Asp Pro Arg Cys Arg Tyr Arg Cys Arg 
1               5                   10              


<210>  2
<211>  13
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Conotoxin Peptide Analog


<220>
<221>  VARIANT
<222>  (9)..(9)
<223>  Xaa is Arg or citrulline

<220>
<221>  MISC_FEATURE
<222>  (10)..(10)
<223>  Xaa is mono-iodo-Tyr

<220>
<221>  VARIANT
<222>  (13)..(13)
<223>  Xaa is Tyr, Phe, Trp, Tyr-Tyr, Tyr-Arg, Arg-Arg-Arg, Arg-Arg-Tyr 
       or Tyr-Arg-Arg

<400>  2

Gly Cys Cys Thr Asp Pro Arg Cys Xaa Xaa Gln Cys Xaa 
1               5                   10              


<210>  3
<211>  13
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Conotoxin Peptide Analog


<220>
<221>  MISC_FEATURE
<222>  (9)..(9)
<223>  Xaa is citrulline.

<220>
<221>  MISC_FEATURE
<222>  (10)..(10)
<223>  Xaa is mono-iodo-Tyr

<400>  3

Gly Cys Cys Thr Asp Pro Arg Cys Xaa Xaa Gln Cys Tyr 
1               5                   10              


<210>  4
<211>  15
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Conotoxin Peptide Analog


<220>
<221>  MISC_FEATURE
<222>  (9)..(9)
<223>  Xaa is citrulline.

<220>
<221>  MISC_FEATURE
<222>  (10)..(10)
<223>  Xaa is mono-iodo-Tyr

<400>  4

Gly Cys Cys Thr Asp Pro Arg Cys Xaa Xaa Gln Cys Arg Arg Arg 
1               5                   10                  15  


<210>  5
<211>  15
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Conotoxin Peptide Analog


<220>
<221>  MISC_FEATURE
<222>  (9)..(9)
<223>  Xaa is citrulline

<220>
<221>  MISC_FEATURE
<222>  (10)..(10)
<223>  Xaa is mono-iodo-Tyr

<400>  5

Gly Cys Cys Thr Asp Pro Arg Cys Xaa Xaa Gln Cys Tyr Arg Arg 
1               5                   10                  15  


<210>  6
<211>  15
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Conotoxin Peptide Analog


<220>
<221>  MISC_FEATURE
<222>  (9)..(9)
<223>  Xaa is citrulline

<220>
<221>  MISC_FEATURE
<222>  (10)..(10)
<223>  Xaa is mono-iodo-Tyr

<400>  6

Gly Cys Cys Thr Asp Pro Arg Cys Xaa Xaa Gln Cys Arg Arg Tyr 
1               5                   10                  15  


<210>  7
<211>  13
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Conotoxin Peptide Analog


<220>
<221>  MISC_FEATURE
<222>  (9)..(9)
<223>  Xaa is citrulline

<220>
<221>  MISC_FEATURE
<222>  (10)..(10)
<223>  Xaa is mono-iodo-Tyr

<400>  7

Gly Cys Cys Thr Asp Pro Arg Cys Xaa Xaa Gln Cys Phe 
1               5                   10              


<210>  8
<211>  13
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Conotoxin Peptide Analog


<220>
<221>  MISC_FEATURE
<222>  (9)..(9)
<223>  Xaa is citrulline

<220>
<221>  MISC_FEATURE
<222>  (10)..(10)
<223>  Xaa is mono-iodo-Tyr

<400>  8

Gly Cys Cys Thr Asp Pro Arg Cys Xaa Xaa Gln Cys Trp 
1               5                   10              


<210>  9
<211>  14
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Conotoxin Peptide Analog


<220>
<221>  MISC_FEATURE
<222>  (9)..(9)
<223>  Xaa is citrulline

<220>
<221>  MISC_FEATURE
<222>  (10)..(10)
<223>  Xaa is mono-iodo-Tyr

<400>  9

Gly Cys Cys Thr Asp Pro Arg Cys Xaa Xaa Gln Cys Tyr Tyr 
1               5                   10                  


<210>  10
<211>  14
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Conotoxin Peptide Analog


<220>
<221>  MISC_FEATURE
<222>  (9)..(9)
<223>  Xaa is citrulline

<220>
<221>  MISC_FEATURE
<222>  (10)..(10)
<223>  Xaa is mono-iodo-Tyr

<400>  10

Gly Cys Cys Thr Asp Pro Arg Cys Xaa Xaa Gln Cys Tyr Arg 
1               5                   10                  


<210>  11
<211>  13
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Conotoxin Peptide Analog


<220>
<221>  MISC_FEATURE
<222>  (10)..(10)
<223>  Xaa is mono-iodo-Tyr

<400>  11

Gly Cys Cys Thr Asp Pro Arg Cys Arg Xaa Gln Cys Tyr 
1               5                   10              


<210>  12
<211>  15
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Conotoxin Peptide Analog


<220>
<221>  MISC_FEATURE
<222>  (10)..(10)
<223>  Xaa is mono-iodo-Tyr

<400>  12

Gly Cys Cys Thr Asp Pro Arg Cys Arg Xaa Gln Cys Arg Arg Arg 
1               5                   10                  15  


<210>  13
<211>  15
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Conotoxin Peptide Analog


<220>
<221>  MISC_FEATURE
<222>  (10)..(10)
<223>  Xaa is mono-iodo-Tyr

<400>  13

Gly Cys Cys Thr Asp Pro Arg Cys Arg Xaa Gln Cys Tyr Arg Arg 
1               5                   10                  15  


<210>  14
<211>  15
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Conotoxin Peptide Analog


<220>
<221>  MISC_FEATURE
<222>  (10)..(10)
<223>  Xaa is mono-iodo-Tyr

<400>  14

Gly Cys Cys Thr Asp Pro Arg Cys Arg Xaa Gln Cys Arg Arg Tyr 
1               5                   10                  15  


<210>  15
<211>  13
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Conotoxin Peptide Analog


<220>
<221>  MISC_FEATURE
<222>  (10)..(10)
<223>  Xaa is mono-iodo-Tyr

<400>  15

Gly Cys Cys Thr Asp Pro Arg Cys Arg Xaa Gln Cys Phe 
1               5                   10              


<210>  16
<211>  13
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Conotoxin Peptide Analog


<220>
<221>  MISC_FEATURE
<222>  (10)..(10)
<223>  Xaa is mono-iodo-Tyr

<400>  16

Gly Cys Cys Thr Asp Pro Arg Cys Arg Xaa Gln Cys Trp 
1               5                   10              


<210>  17
<211>  14
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Conotoxin Peptide Analog


<220>
<221>  MISC_FEATURE
<222>  (10)..(10)
<223>  Xaa is mono-iodo-Tyr

<400>  17

Gly Cys Cys Thr Asp Pro Arg Cys Arg Xaa Gln Cys Tyr Tyr 
1               5                   10                  


<210>  18
<211>  14
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Conotoxin Peptide Analog


<220>
<221>  MISC_FEATURE
<222>  (10)..(10)
<223>  Xaa is mono-iodo-Tyr

<400>  18

Gly Cys Cys Thr Asp Pro Arg Cys Arg Xaa Gln Cys Tyr Arg 
1               5                   10                  


<210>  19
<211>  13
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Conotoxin Peptide Analog


<220>
<221>  MISC_FEATURE
<222>  (9)..(9)
<223>  Xaa is citrulline.

<220>
<221>  MISC_FEATURE
<222>  (10)..(10)
<223>  Xaa is mono-iodo-Tyr

<400>  19

Gly Cys Cys Thr Asp Pro Arg Cys Xaa Xaa Gln Cys Arg 
1               5                   10              


<210>  20
<211>  13
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Conotoxin Peptide Analog


<220>
<221>  MISC_FEATURE
<222>  (2)..(2)
<223>  Xaa is selenocysteine.

<220>
<221>  MISC_FEATURE
<222>  (3)..(3)
<223>  Xaa is selenocysteine.

<220>
<221>  MISC_FEATURE
<222>  (9)..(9)
<223>  Xaa is citrulline.

<220>
<221>  MISC_FEATURE
<222>  (10)..(10)
<223>  Xaa is mono-iodo-Tyr

<400>  20

Gly Xaa Xaa Thr Asp Pro Arg Cys Xaa Xaa Gln Cys Arg 
1               5                   10              


<210>  21
<211>  13
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Conotoxin Peptide Analog


<220>
<221>  MISC_FEATURE
<222>  (10)..(10)
<223>  Xaa is mono-iodo-Tyr

<400>  21

Gly Cys Cys Ser Asp Pro Arg Cys Arg Xaa Arg Cys Arg 
1               5                   10              


<210>  22
<211>  13
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Conotoxin Peptide Analog


<220>
<221>  VARIANT
<222>  (2)..(2)
<223>  Xaa is Cys or selenocysteine

<220>
<221>  VARIANT
<222>  (3)..(3)
<223>  Xaa is Cys or selenocysteine

<220>
<221>  VARIANT
<222>  (4)..(4)
<223>  Xaa is Ser or Thr

<220>
<221>  VARIANT
<222>  (8)..(8)
<223>  Xaa is Cys or selenocysteine

<220>
<221>  VARIANT
<222>  (9)..(9)
<223>  Xaa is Arg, citrulline, or [omega]-nitro-Arg

<220>
<221>  VARIANT
<222>  (10)..(10)
<223>  Xaa is Tyr or mono-iodo-Tyr

<220>
<221>  VARIANT
<222>  (11)..(11)
<223>  Xaa is Arg, Gln, or Glu

<220>
<221>  VARIANT
<222>  (12)..(12)
<223>  Xaa is Cys or selenocysteine

<220>
<221>  VARIANT
<222>  (13)..(13)
<223>  Xaa is Arg, Tyr, Phe, Trp, Tyr-Tyr, Tyr-Arg, Arg-Arg-Arg, 
       Arg-Arg-Tyr, or Tyr-Arg-Arg

<400>  22

Gly Xaa Xaa Xaa Asp Pro Arg Xaa Xaa Xaa Xaa Xaa Xaa 
1               5                   10              


