               SEQUENCE LISTING

<110> DCB-USA LLC
      Kaohsiung Medical University

<120> ANTIBODY LOCKER FOR THE INACTIVATION OF PROTEIN DRUG

<130> P2757-1-PCT

<150> PCT/US61/827,763
<151> 2013-05-28

<160> 78

<170> BiSSAP 1.3

<210> 1
<211> 214
<212> PRT
<213> Artificial Sequence

<220> 
<223> infliximab light chain

<400> 1
Asp Ile Leu Leu Thr Gln Ser Pro Ala Ile Leu Ser Val Ser Pro Gly 
1               5                   10                  15      
Glu Arg Val Ser Phe Ser Cys Arg Ala Ser Gln Phe Val Gly Ser Ser 
            20                  25                  30          
Ile His Trp Tyr Gln Gln Arg Thr Asn Gly Ser Pro Arg Leu Leu Ile 
        35                  40                  45              
Lys Tyr Ala Ser Glu Ser Met Ser Gly Ile Pro Ser Arg Phe Ser Gly 
    50                  55                  60                  
Ser Gly Ser Gly Thr Asp Phe Thr Leu Ser Ile Asn Thr Val Glu Ser 
65                  70                  75                  80  
Glu Asp Ile Ala Asp Tyr Tyr Cys Gln Gln Ser His Ser Trp Pro Phe 
                85                  90                  95      
Thr Phe Gly Ser Gly Thr Asn Leu Glu Val Lys Arg Thr Val Ala Ala 
            100                 105                 110         
Pro Ser Val Phe Ile Phe Pro Pro Ser Asp Glu Gln Leu Lys Ser Gly 
        115                 120                 125             
Thr Ala Ser Val Val Cys Leu Leu Asn Asn Phe Tyr Pro Arg Glu Ala 
    130                 135                 140                 
Lys Val Gln Trp Lys Val Asp Asn Ala Leu Gln Ser Gly Asn Ser Gln 
145                 150                 155                 160 
Glu Ser Val Thr Glu Gln Asp Ser Lys Asp Ser Thr Tyr Ser Leu Ser 
                165                 170                 175     
Ser Thr Leu Thr Leu Ser Lys Ala Asp Tyr Glu Lys His Lys Leu Tyr 
            180                 185                 190         
Ala Cys Glu Val Thr His Gln Gly Leu Ser Ser Pro Val Thr Lys Ser 
        195                 200                 205             
Phe Asn Arg Gly Glu Cys 
    210                 

<210> 2
<211> 221
<212> PRT
<213> Artificial Sequence

<220> 
<223> Panitumumab light chain

<400> 2
Asp Ile Val Met Thr Gln Ser Pro Leu Ser Leu Pro Val Thr Pro Gly 
1               5                   10                  15      
Glu Pro Ala Ser Ile Ser Cys Arg Ser Ser Gln Asn Ile Val His Asn 
            20                  25                  30          
Asn Gly Ile Thr Tyr Leu Glu Trp Tyr Leu Gln Lys Pro Gly Gln Ser 
        35                  40                  45              
Pro Gln Leu Leu Ile Tyr Lys Val Ser Asp Arg Phe Ser Gly Val Pro 
    50                  55                  60                  
Asp Arg Phe Ser Gly Ser Gly Ser Gly Thr Asp Phe Thr Leu Lys Ile 
65                  70                  75                  80  
Ser Arg Val Glu Ala Glu Asp Val Gly Val Tyr Tyr Cys Phe Gln Gly 
                85                  90                  95      
Ser His Ile Pro Pro Thr Phe Gly Gln Gly Thr Lys Val Glu Ile Lys 
            100                 105                 110         
Arg Ala Arg Thr Val Ala Ala Pro Ser Val Phe Ile Phe Pro Pro Ser 
        115                 120                 125             
Asp Glu Gln Leu Lys Ser Gly Thr Ala Ser Val Val Cys Leu Leu Asn 
    130                 135                 140                 
Asn Phe Tyr Pro Arg Glu Ala Lys Val Gln Trp Lys Val Asp Asn Ala 
145                 150                 155                 160 
Leu Gln Ser Gly Asn Ser Gln Glu Ser Val Thr Glu Gln Asp Ser Lys 
                165                 170                 175     
Asp Ser Thr Tyr Ser Leu Ser Ser Thr Leu Thr Leu Ser Lys Ala Asp 
            180                 185                 190         
Tyr Glu Lys His Lys Leu Tyr Ala Cys Glu Val Thr His Gln Gly Leu 
        195                 200                 205             
Ser Ser Pro Val Thr Lys Ser Phe Asn Arg Gly Glu Cys 
    210                 215                 220     

<210> 3
<211> 215
<212> PRT
<213> Artificial Sequence

<220> 
<223> Trastuzumab light chain

<400> 3
Ala Asp Ile Gln Met Thr Gln Ser Pro Ser Ser Leu Ser Ala Ser Val 
1               5                   10                  15      
Gly Asp Arg Val Thr Ile Thr Cys Arg Ala Ser Gln Asp Val Asn Thr 
            20                  25                  30          
Ala Val Ala Trp Tyr Gln Gln Lys Pro Gly Lys Ala Pro Lys Leu Leu 
        35                  40                  45              
Ile Tyr Ser Ala Ser Phe Leu Tyr Ser Gly Val Pro Ser Arg Phe Ser 
    50                  55                  60                  
Gly Ser Arg Ser Gly Thr Asp Phe Thr Leu Thr Ile Ser Ser Leu Gln 
65                  70                  75                  80  
Pro Glu Asp Phe Ala Thr Tyr Tyr Cys Gln Gln His Tyr Thr Thr Pro 
                85                  90                  95      
Pro Thr Phe Gly Gln Gly Thr Lys Val Glu Ile Lys Arg Thr Val Ala 
            100                 105                 110         
Ala Pro Ser Val Phe Ile Phe Pro Pro Ser Asp Glu Gln Leu Lys Ser 
        115                 120                 125             
Gly Thr Ala Ser Val Val Cys Leu Leu Asn Asn Phe Tyr Pro Arg Glu 
    130                 135                 140                 
Ala Lys Val Gln Trp Lys Val Asp Asn Ala Leu Gln Ser Gly Asn Ser 
145                 150                 155                 160 
Gln Glu Ser Val Thr Glu Gln Asp Ser Lys Asp Ser Thr Tyr Ser Leu 
                165                 170                 175     
Ser Ser Thr Leu Thr Leu Ser Lys Ala Asp Tyr Glu Lys His Lys Val 
            180                 185                 190         
Tyr Ala Cys Glu Val Thr His Gln Gly Leu Ser Ser Pro Val Thr Lys 
        195                 200                 205             
Ser Phe Asn Arg Gly Glu Cys 
    210                 215 

<210> 4
<211> 215
<212> PRT
<213> Artificial Sequence

<220> 
<223> adalimumab light chain

<400> 4
Ala Asp Ile Gln Met Thr Gln Ser Pro Ser Ser Leu Ser Ala Ser Val 
1               5                   10                  15      
Gly Asp Arg Val Thr Ile Thr Cys Arg Ala Ser Gln Gly Ile Arg Asn 
            20                  25                  30          
Tyr Leu Ala Trp Tyr Gln Gln Lys Pro Gly Lys Ala Pro Lys Leu Leu 
        35                  40                  45              
Ile Tyr Ala Ala Ser Thr Leu Gln Ser Gly Val Pro Ser Arg Phe Ser 
    50                  55                  60                  
Gly Ser Gly Ser Gly Thr Asp Phe Thr Leu Thr Ile Ser Ser Leu Gln 
65                  70                  75                  80  
Pro Glu Asp Val Ala Thr Tyr Tyr Cys Gln Arg Tyr Asn Arg Ala Pro 
                85                  90                  95      
Tyr Thr Phe Gly Gln Gly Thr Lys Val Glu Ile Lys Arg Thr Val Ala 
            100                 105                 110         
Ala Pro Ser Val Phe Ile Phe Pro Pro Ser Asp Glu Gln Leu Lys Ser 
        115                 120                 125             
Gly Thr Ala Ser Val Val Cys Leu Leu Asn Asn Phe Tyr Pro Arg Glu 
    130                 135                 140                 
Ala Lys Val Gln Trp Lys Val Asp Asn Ala Leu Gln Ser Gly Asn Ser 
145                 150                 155                 160 
Gln Glu Ser Val Thr Glu Gln Asp Ser Lys Asp Ser Thr Tyr Ser Leu 
                165                 170                 175     
Ser Ser Thr Leu Thr Leu Ser Lys Ala Asp Tyr Glu Lys His Lys Leu 
            180                 185                 190         
Tyr Ala Cys Glu Val Thr His Gln Gly Leu Ser Ser Pro Val Thr Lys 
        195                 200                 205             
Ser Phe Asn Arg Gly Glu Cys 
    210                 215 

<210> 5
<211> 215
<212> PRT
<213> Artificial Sequence

<220> 
<223> DENOSUMAB LIGHT CHAIN

<400> 5
Glu Ile Val Leu Thr Gln Ser Pro Gly Thr Leu Ser Leu Ser Pro Gly 
1               5                   10                  15      
Glu Arg Ala Thr Leu Ser Cys Arg Ala Ser Gln Ser Val Arg Gly Arg 
            20                  25                  30          
Tyr Leu Ala Trp Tyr Gln Gln Lys Pro Gly Gln Ala Pro Arg Leu Leu 
        35                  40                  45              
Ile Tyr Gly Ala Ser Ser Arg Ala Thr Gly Ile Pro Asp Arg Phe Ser 
    50                  55                  60                  
Gly Ser Gly Ser Gly Thr Asp Phe Thr Leu Thr Ile Ser Arg Leu Glu 
65                  70                  75                  80  
Pro Glu Asp Phe Ala Val Phe Tyr Cys Gln Gln Tyr Gly Ser Ser Pro 
                85                  90                  95      
Arg Thr Phe Gly Gln Gly Thr Lys Val Glu Ile Lys Arg Thr Val Ala 
            100                 105                 110         
Ala Pro Ser Val Phe Ile Phe Pro Pro Ser Asp Glu Gln Leu Lys Ser 
        115                 120                 125             
Gly Thr Ala Ser Val Val Cys Leu Leu Asn Asn Phe Tyr Pro Arg Glu 
    130                 135                 140                 
Ala Lys Val Gln Trp Lys Val Asp Asn Ala Leu Gln Ser Gly Asn Ser 
145                 150                 155                 160 
Gln Glu Ser Val Thr Glu Gln Asp Ser Lys Asp Ser Thr Tyr Ser Leu 
                165                 170                 175     
Ser Ser Thr Leu Thr Leu Ser Lys Ala Asp Tyr Glu Lys His Lys Leu 
            180                 185                 190         
Tyr Ala Cys Glu Val Thr His Gln Gly Leu Ser Ser Pro Val Thr Lys 
        195                 200                 205             
Ser Phe Asn Arg Gly Glu Cys 
    210                 215 

<210> 6
<211> 215
<212> PRT
<213> Artificial Sequence

<220> 
<223> Ipilimumab light chain

<400> 6
Glu Ile Val Leu Thr Gln Ser Pro Gly Thr Leu Ser Leu Ser Pro Gly 
1               5                   10                  15      
Glu Arg Ala Thr Leu Ser Cys Arg Ala Ser Gln Ser Val Gly Ser Ser 
            20                  25                  30          
Tyr Leu Ala Trp Tyr Gln Gln Lys Pro Gly Gln Ala Pro Arg Leu Leu 
        35                  40                  45              
Ile Tyr Gly Ala Phe Ser Arg Ala Thr Gly Ile Pro Asp Arg Phe Ser 
    50                  55                  60                  
Gly Ser Gly Ser Gly Thr Asp Phe Thr Leu Thr Ile Ser Arg Leu Glu 
65                  70                  75                  80  
Pro Glu Asp Phe Ala Val Tyr Tyr Cys Gln Gln Tyr Gly Ser Ser Pro 
                85                  90                  95      
Trp Thr Phe Gly Gln Gly Thr Lys Val Glu Ile Lys Arg Thr Val Ala 
            100                 105                 110         
Ala Pro Ser Val Phe Ile Phe Pro Pro Ser Asp Glu Gln Leu Lys Ser 
        115                 120                 125             
Gly Thr Ala Ser Val Val Cys Leu Leu Asn Asn Phe Tyr Pro Arg Glu 
    130                 135                 140                 
Ala Lys Val Gln Trp Lys Val Asp Asn Ala Leu Gln Ser Gly Asn Ser 
145                 150                 155                 160 
Gln Glu Ser Val Thr Glu Gln Asp Ser Lys Asp Ser Thr Tyr Ser Leu 
                165                 170                 175     
Ser Ser Thr Leu Thr Leu Ser Lys Ala Asp Tyr Glu Lys His Lys Leu 
            180                 185                 190         
Tyr Ala Cys Glu Val Thr His Gln Gly Leu Ser Ser Pro Val Thr Lys 
        195                 200                 205             
Ser Phe Asn Arg Gly Glu Cys 
    210                 215 

<210> 7
<211> 214
<212> PRT
<213> Artificial Sequence

<220> 
<223> tremelimumab light chain

<400> 7
Asp Ile Gln Met Thr Gln Ser Pro Ser Ser Leu Ser Ala Ser Val Gly 
1               5                   10                  15      
Asp Arg Val Thr Ile Thr Cys Arg Ala Ser Gln Ser Ile Asn Ser Tyr 
            20                  25                  30          
Leu Asp Trp Tyr Gln Gln Lys Pro Gly Lys Ala Pro Lys Leu Leu Ile 
        35                  40                  45              
Tyr Ala Ala Ser Ser Leu Gln Ser Gly Val Pro Ser Arg Phe Ser Gly 
    50                  55                  60                  
Ser Gly Ser Gly Thr Asp Phe Thr Leu Thr Ile Ser Ser Leu Gln Pro 
65                  70                  75                  80  
Glu Asp Phe Ala Thr Tyr Tyr Cys Gln Gln Tyr Tyr Ser Thr Pro Phe 
                85                  90                  95      
Thr Phe Gly Pro Gly Thr Lys Val Glu Ile Lys Arg Thr Val Ala Ala 
            100                 105                 110         
Pro Ser Val Phe Ile Phe Pro Pro Ser Asp Glu Gln Leu Lys Ser Gly 
        115                 120                 125             
Thr Ala Ser Val Val Cys Leu Leu Asn Asn Phe Tyr Pro Arg Glu Ala 
    130                 135                 140                 
Lys Val Gln Trp Lys Val Asp Asn Ala Leu Gln Ser Gly Asn Ser Gln 
145                 150                 155                 160 
Glu Ser Val Thr Glu Gln Asp Ser Lys Asp Ser Thr Tyr Ser Leu Ser 
                165                 170                 175     
Ser Thr Leu Thr Leu Ser Lys Ala Asp Tyr Glu Lys His Lys Leu Tyr 
            180                 185                 190         
Ala Cys Glu Val Thr His Gln Gly Leu Ser Ser Pro Val Thr Lys Ser 
        195                 200                 205             
Phe Asn Arg Gly Glu Cys 
    210                 

<210> 8
<211> 219
<212> PRT
<213> Artificial Sequence

<220> 
<223> efalizumab light chain

<400> 8
Ala Ala Gln Pro Ala Asp Ile Gln Met Thr Gln Ser Pro Ser Ser Leu 
1               5                   10                  15      
Ser Ala Ser Val Gly Asp Arg Val Thr Ile Thr Cys Arg Ala Ser Lys 
            20                  25                  30          
Thr Ile Ser Lys Tyr Leu Ala Trp Tyr Gln Gln Lys Pro Gly Lys Ala 
        35                  40                  45              
Pro Lys Leu Leu Ile Tyr Ser Gly Ser Thr Leu Gln Ser Gly Val Pro 
    50                  55                  60                  
Ser Arg Phe Ser Gly Ser Gly Ser Gly Thr Asp Phe Thr Leu Thr Ile 
65                  70                  75                  80  
Ser Ser Leu Gln Pro Glu Asp Phe Ala Thr Tyr Tyr Cys Gln Gln His 
                85                  90                  95      
Asn Glu Tyr Pro Leu Thr Phe Gly Gln Gly Thr Lys Val Glu Ile Lys 
            100                 105                 110         
Arg Thr Val Ala Ala Pro Ser Val Phe Ile Phe Pro Pro Ser Asp Glu 
        115                 120                 125             
Gln Leu Lys Ser Gly Thr Ala Ser Val Val Cys Leu Leu Asn Asn Phe 
    130                 135                 140                 
Tyr Pro Arg Glu Ala Lys Val Gln Trp Lys Val Asp Asn Ala Leu Gln 
145                 150                 155                 160 
Ser Gly Asn Ser Gln Glu Ser Val Thr Glu Gln Asp Ser Lys Asp Ser 
                165                 170                 175     
Thr Tyr Ser Leu Ser Ser Thr Leu Thr Leu Ser Lys Ala Asp Tyr Glu 
            180                 185                 190         
Lys His Lys Leu Tyr Ala Cys Glu Val Thr His Gln Gly Leu Ser Ser 
        195                 200                 205             
Pro Val Thr Lys Ser Phe Asn Arg Gly Glu Cys 
    210                 215                 

<210> 9
<211> 216
<212> PRT
<213> Artificial Sequence

<220> 
<223> ustekinumab light chain

<400> 9
Asp Ile Gln Met Thr Gln Ser Pro Ser Ser Leu Ser Ala Ser Val Gly 
1               5                   10                  15      
Asp Arg Val Thr Ile Thr Cys Arg Ala Ser Gln Gly Ile Ser Ser Trp 
            20                  25                  30          
Leu Ala Trp Tyr Gln Gln Lys Pro Glu Lys Ala Pro Lys Ser Leu Ile 
        35                  40                  45              
Tyr Ala Ala Ser Ser Leu Gln Ser Gly Val Pro Ser Arg Phe Ser Gly 
    50                  55                  60                  
Ser Gly Ser Gly Thr Asp Phe Thr Leu Thr Ile Ser Ser Leu Gln Pro 
65                  70                  75                  80  
Glu Asp Phe Ala Thr Tyr Tyr Cys Gln Gln Tyr Asn Ile Tyr Pro Tyr 
                85                  90                  95      
Thr Phe Gly Gln Gly Thr Lys Leu Glu Ile Lys Arg Thr Val Ala Ala 
            100                 105                 110         
Pro Ser Val Phe Ile Phe Pro Pro Ser Asp Glu Gln Leu Lys Ser Gly 
        115                 120                 125             
Thr Ala Ser Val Val Cys Leu Leu Asn Asn Phe Tyr Pro Arg Glu Ala 
    130                 135                 140                 
Lys Val Gln Trp Lys Val Asp Asn Ala Leu Gln Ser Gly Asn Ser Gln 
145                 150                 155                 160 
Glu Ser Val Thr Glu Gln Asp Ser Lys Asp Ser Thr Tyr Ser Leu Ser 
                165                 170                 175     
Ser Thr Leu Thr Leu Ser Lys Ala Asp Tyr Glu Lys His Lys Leu Tyr 
            180                 185                 190         
Ala Cys Glu Val Thr His Gln Gly Leu Ser Ser Pro Val Thr Lys Ser 
        195                 200                 205             
Phe Asn Arg Gly Glu Cys Leu Glu 
    210                 215     

<210> 10
<211> 15
<212> PRT
<213> Artificial Sequence

<220> 
<223> IgG1 hinge

<400> 10
Glu Pro Lys Ser Cys Asp Lys Thr His Thr Cys Pro Pro Cys Pro 
1               5                   10                  15  

<210> 11
<211> 12
<212> PRT
<213> Artificial Sequence

<220> 
<223> IgG2 hinge

<400> 11
Glu Arg Lys Cys Cys Val Glu Cys Pro Pro Cys Pro 
1               5                   10          

<210> 12
<211> 62
<212> PRT
<213> Artificial Sequence

<220> 
<223> IgG3 hinge

<400> 12
Glu Leu Lys Thr Pro Leu Gly Asp Thr Thr His Thr Cys Pro Arg Cys 
1               5                   10                  15      
Pro Glu Pro Lys Ser Cys Asp Thr Pro Pro Pro Cys Pro Arg Cys Pro 
            20                  25                  30          
Glu Pro Lys Ser Cys Asp Thr Pro Pro Pro Cys Pro Arg Cys Pro Glu 
        35                  40                  45              
Pro Lys Ser Cys Asp Thr Pro Pro Pro Cys Pro Arg Cys Pro 
    50                  55                  60          

<210> 13
<211> 12
<212> PRT
<213> Artificial Sequence

<220> 
<223> IgG4 hinge

<400> 13
Glu Ser Lys Tyr Gly Pro Pro Cys Pro Ser Cys Pro 
1               5                   10          

<210> 14
<211> 23
<212> PRT
<213> Artificial Sequence

<220> 
<223> IgA1 hinge

<400> 14
Pro Val Pro Ser Thr Pro Pro Thr Pro Ser Pro Ser Thr Pro Pro Thr 
1               5                   10                  15      
Pro Ser Pro Ser Cys Cys His 
            20              

<210> 15
<211> 10
<212> PRT
<213> Artificial Sequence

<220> 
<223> IgA2 hinge

<400> 15
Pro Val Pro Pro Pro Pro Pro Cys Cys His 
1               5                   10  

<210> 16
<211> 6
<212> PRT
<213> Artificial Sequence

<220> 
<223> MMP2 substrate

<400> 16
Gly Pro Leu Gly Val Arg 
1               5       

<210> 17
<211> 2445
<212> DNA
<213> Artificial Sequence

<220> 
<223> IgG1 Hinge Ipilimumab

<400> 17
gctagcaagc ttgttatcca ccatggagac agacacactc ctgctatggg tactgctgct      60

ctgggttcca ggttccactg gtgacgagcc caaatcttgt gacaaaactc acacatgccc     120

accgtgccca gttaacggcg gcggcggcag cggtcccctg ggtgtgagag cggcccagcc     180

ggccgaaatt gtgttgacgc agtctccagg caccctgtct ttgtctccag gggaaagagc     240

caccctctcc tgcagggcca gtcagagtgt tggcagcagc tacttagcct ggtaccagca     300

gaaacctggc caggctccca ggctcctcat ctatggtgca ttcagcaggg ccactggcat     360

cccagacagg ttcagtggca gtgggtctgg gacagacttc actctcacca tcagcagact     420

ggagcctgaa gattttgcag tgtattactg tcagcagtat ggtagctcac cgtggacgtt     480

cggccaaggg accaaggtgg aaatcaaacg gactgtggct gcaccatctg tcttcatctt     540

cccgccatct gatgagcagt tgaaatctgg aactgcctct gttgtgtgcc tgctgaataa     600

cttctatccc agagaggcca aagtacagtg gaaggtggat aacgccctcc aatcgggtaa     660

ctcccaggag agtgtcacag agcaggacag caaggacagc acctacagcc tcagcagcac     720

cctgacgctg agcaaagcag actacgagaa acacaaactc tacgcctgcg aagtcaccca     780

tcagggcctg agctcgcccg tcacaaagag cttcaacagg ggagagtgcc tcgagcgagc     840

aaaacgagca ccagtaaaac aaacactaaa cttcgaccta ctaaaactag caggagacgt     900

agaatcaaac ccaggaccag ccacaaccat ggagacagac acactcctgc tatgggtact     960

gctgctctgg gttccaggtt ccactggtga cgagcccaaa tcttgtgaca aaactcacac    1020

atgcccaccg tgcccaggcg gccgcggcgg cggcggcagc ggtcccctgg gtgtgagaag    1080

atctcaggtg cagctggtgg agtctggggg aggcgtggtc cagcctggga ggtccctgag    1140

actctcctgt gcagcctctg gattcacctt cagtagctat actatgcact gggtccgcca    1200

ggctccaggc aaggggctgg agtgggtgac atttatatca tatgatggaa acaataaata    1260

ctacgcagac tccgtgaagg gccgattcac catctccaga gacaattcca agaacacgct    1320

gtatctgcaa atgaacagcc tgagagctga ggacacggct atatattact gtgcgaggac    1380

cggctggctg gggccctttg actactgggg ccagggaacc ctggtcaccg tctcctcagc    1440

ctccaccaag ggaccatcgg tcttccccct ggcaccctcc tccaagagca cctctggggg    1500

cacagcggcc ctgggctgcc tggtcaagga ctacttcccc gaaccggtga cggtgtcgtg    1560

gaactcaggc gccctgacca gcggcgtgca caccttcccg gctgtcctac agtcctcagg    1620

actctactcc ctcagcagcg tggtgaccgt gccctccagc agcttgggca cccagaccta    1680

catctgcaac gtgaatcaca agcccagcaa caccaaggtc gacaagaaag ttgagcccaa    1740

atcttgtgac aaaactcaca catgcccacc gtgcccagca cccgaactcc tggggggacc    1800

gtcagtcttc ctcttccccc caaaacccaa ggacaccctc atgatctccc ggacccctga    1860

ggtcacatgc gtggtggtgg acgtgagcca cgaagaccct gaggtcaagt tcaactggta    1920

cgtggacggc gtggaggtgc ataatgccaa gacaaagccg cgggaggagc agtacaacag    1980

cacgtaccgt gtggtcagcg tcctcaccgt cctgcaccag gactggctga atggcaagga    2040

gtacaagtgc aaggtctcca acaaagccct cccagccccc atcgagaaaa ccatctccaa    2100

agccaagggg cagccccgag aaccacaggt gtacaccctg cccccatccc gggatgagct    2160

gaccaagaac caggtcagcc tgacctgcct ggtcaaaggc ttctatccca gcgacatcgc    2220

cgtggagtgg gagagcaatg ggcagccgga gaacaactac aagaccacgc ctcccgtgct    2280

ggactccgac ggctccttct tcctctacag caagctcacc gtggacaaga gcaggtggca    2340

gcaggggaac gtcttctcat gctccgtgat gcatgaggct ctgcacaacc actacacgca    2400

gaagagcctc tccctgtctc cgggtaaata aatcgatggc gcgcc                    2445


<210> 18
<211> 2427
<212> DNA
<213> Artificial Sequence

<220> 
<223> IgG2 Hinge Ipilimumab

<400> 18
gctagcaagc ttgttatcca ccatggagac agacacactc ctgctatggg tactgctgct      60

ctgggttcca ggttccactg gtgacgagcg caaatgttgt gtcgagtgcc caccgtgccc     120

agttaacggc ggcggcggca gcggtcccct gggtgtgaga gcggcccagc cggccgaaat     180

tgtgttgacg cagtctccag gcaccctgtc tttgtctcca ggggaaagag ccaccctctc     240

ctgcagggcc agtcagagtg ttggcagcag ctacttagcc tggtaccagc agaaacctgg     300

ccaggctccc aggctcctca tctatggtgc attcagcagg gccactggca tcccagacag     360

gttcagtggc agtgggtctg ggacagactt cactctcacc atcagcagac tggagcctga     420

agattttgca gtgtattact gtcagcagta tggtagctca ccgtggacgt tcggccaagg     480

gaccaaggtg gaaatcaaac ggactgtggc tgcaccatct gtcttcatct tcccgccatc     540

tgatgagcag ttgaaatctg gaactgcctc tgttgtgtgc ctgctgaata acttctatcc     600

cagagaggcc aaagtacagt ggaaggtgga taacgccctc caatcgggta actcccagga     660

gagtgtcaca gagcaggaca gcaaggacag cacctacagc ctcagcagca ccctgacgct     720

gagcaaagca gactacgaga aacacaaact ctacgcctgc gaagtcaccc atcagggcct     780

gagctcgccc gtcacaaaga gcttcaacag gggagagtgc ctcgagcgag caaaacgagc     840

accagtaaaa caaacactaa acttcgacct actaaaacta gcaggagacg tagaatcaaa     900

cccaggacca gccacaacca tggagacaga cacactcctg ctatgggtac tgctgctctg     960

ggttccaggt tccactggtg acgagcgcaa atgttgtgtc gagtgcccac cgtgcccagg    1020

cggccgcggc ggcggcggca gcggtcccct gggtgtgaga agatctcagg tgcagctggt    1080

ggagtctggg ggaggcgtgg tccagcctgg gaggtccctg agactctcct gtgcagcctc    1140

tggattcacc ttcagtagct atactatgca ctgggtccgc caggctccag gcaaggggct    1200

ggagtgggtg acatttatat catatgatgg aaacaataaa tactacgcag actccgtgaa    1260

gggccgattc accatctcca gagacaattc caagaacacg ctgtatctgc aaatgaacag    1320

cctgagagct gaggacacgg ctatatatta ctgtgcgagg accggctggc tggggccctt    1380

tgactactgg ggccagggaa ccctggtcac cgtctcctca gcctccacca agggaccatc    1440

ggtcttcccc ctggcaccct cctccaagag cacctctggg ggcacagcgg ccctgggctg    1500

cctggtcaag gactacttcc ccgaaccggt gacggtgtcg tggaactcag gcgccctgac    1560

cagcggcgtg cacaccttcc cggctgtcct acagtcctca ggactctact ccctcagcag    1620

cgtggtgacc gtgccctcca gcagcttggg cacccagacc tacatctgca acgtgaatca    1680

caagcccagc aacaccaagg tcgacaagaa agttgagccc aaatcttgtg acaaaactca    1740

cacatgccca ccgtgcccag cacccgaact cctgggggga ccgtcagtct tcctcttccc    1800

cccaaaaccc aaggacaccc tcatgatctc ccggacccct gaggtcacat gcgtggtggt    1860

ggacgtgagc cacgaagacc ctgaggtcaa gttcaactgg tacgtggacg gcgtggaggt    1920

gcataatgcc aagacaaagc cgcgggagga gcagtacaac agcacgtacc gtgtggtcag    1980

cgtcctcacc gtcctgcacc aggactggct gaatggcaag gagtacaagt gcaaggtctc    2040

caacaaagcc ctcccagccc ccatcgagaa aaccatctcc aaagccaagg ggcagccccg    2100

agaaccacag gtgtacaccc tgcccccatc ccgggatgag ctgaccaaga accaggtcag    2160

cctgacctgc ctggtcaaag gcttctatcc cagcgacatc gccgtggagt gggagagcaa    2220

tgggcagccg gagaacaact acaagaccac gcctcccgtg ctggactccg acggctcctt    2280

cttcctctac agcaagctca ccgtggacaa gagcaggtgg cagcagggga acgtcttctc    2340

atgctccgtg atgcatgagg ctctgcacaa ccactacacg cagaagagcc tctccctgtc    2400

tccgggtaaa taaatcgatg gcgcgcc                                        2427


<210> 19
<211> 2727
<212> DNA
<213> Artificial Sequence

<220> 
<223> IgG3 Hinge Ipilimumab

<400> 19
gctagcaagc ttgttatcca ccatggagac agacacactc ctgctatggg tactgctgct      60

ctgggttcca ggttccactg gtgacgagct caaaacccca cttggtgaca caactcacac     120

atgcccacgg tgcccagagc ccaaatcttg tgacacacct cccccgtgcc cacggtgccc     180

agagcccaaa tcttgtgaca cacctccccc atgcccacgg tgcccagagc ccaaatcttg     240

tgacacacct cccccgtgcc caaggtgccc agttaacggc ggcggcggca gcggtcccct     300

gggtgtgaga gcggcccagc cggccgaaat tgtgttgacg cagtctccag gcaccctgtc     360

tttgtctcca ggggaaagag ccaccctctc ctgcagggcc agtcagagtg ttggcagcag     420

ctacttagcc tggtaccagc agaaacctgg ccaggctccc aggctcctca tctatggtgc     480

attcagcagg gccactggca tcccagacag gttcagtggc agtgggtctg ggacagactt     540

cactctcacc atcagcagac tggagcctga agattttgca gtgtattact gtcagcagta     600

tggtagctca ccgtggacgt tcggccaagg gaccaaggtg gaaatcaaac ggactgtggc     660

tgcaccatct gtcttcatct tcccgccatc tgatgagcag ttgaaatctg gaactgcctc     720

tgttgtgtgc ctgctgaata acttctatcc cagagaggcc aaagtacagt ggaaggtgga     780

taacgccctc caatcgggta actcccagga gagtgtcaca gagcaggaca gcaaggacag     840

cacctacagc ctcagcagca ccctgacgct gagcaaagca gactacgaga aacacaaact     900

ctacgcctgc gaagtcaccc atcagggcct gagctcgccc gtcacaaaga gcttcaacag     960

gggagagtgc ctcgagcgag caaaacgagc accagtaaaa caaacactaa acttcgacct    1020

actaaaacta gcaggagacg tagaatcaaa cccaggacca gccacaacca tggagacaga    1080

cacactcctg ctatgggtac tgctgctctg ggttccaggt tccactggtg acgagctcaa    1140

aaccccactt ggtgacacaa ctcacacatg cccacggtgc ccagagccca aatcttgtga    1200

cacacctccc ccgtgcccac ggtgcccaga gcccaaatct tgtgacacac ctcccccatg    1260

cccacggtgc ccagagccca aatcttgtga cacacctccc ccgtgcccaa ggtgcccagg    1320

cggccgcggc ggcggcggca gcggtcccct gggtgtgaga agatctcagg tgcagctggt    1380

ggagtctggg ggaggcgtgg tccagcctgg gaggtccctg agactctcct gtgcagcctc    1440

tggattcacc ttcagtagct atactatgca ctgggtccgc caggctccag gcaaggggct    1500

ggagtgggtg acatttatat catatgatgg aaacaataaa tactacgcag actccgtgaa    1560

gggccgattc accatctcca gagacaattc caagaacacg ctgtatctgc aaatgaacag    1620

cctgagagct gaggacacgg ctatatatta ctgtgcgagg accggctggc tggggccctt    1680

tgactactgg ggccagggaa ccctggtcac cgtctcctca gcctccacca agggaccatc    1740

ggtcttcccc ctggcaccct cctccaagag cacctctggg ggcacagcgg ccctgggctg    1800

cctggtcaag gactacttcc ccgaaccggt gacggtgtcg tggaactcag gcgccctgac    1860

cagcggcgtg cacaccttcc cggctgtcct acagtcctca ggactctact ccctcagcag    1920

cgtggtgacc gtgccctcca gcagcttggg cacccagacc tacatctgca acgtgaatca    1980

caagcccagc aacaccaagg tcgacaagaa agttgagccc aaatcttgtg acaaaactca    2040

cacatgccca ccgtgcccag cacccgaact cctgggggga ccgtcagtct tcctcttccc    2100

cccaaaaccc aaggacaccc tcatgatctc ccggacccct gaggtcacat gcgtggtggt    2160

ggacgtgagc cacgaagacc ctgaggtcaa gttcaactgg tacgtggacg gcgtggaggt    2220

gcataatgcc aagacaaagc cgcgggagga gcagtacaac agcacgtacc gtgtggtcag    2280

cgtcctcacc gtcctgcacc aggactggct gaatggcaag gagtacaagt gcaaggtctc    2340

caacaaagcc ctcccagccc ccatcgagaa aaccatctcc aaagccaagg ggcagccccg    2400

agaaccacag gtgtacaccc tgcccccatc ccgggatgag ctgaccaaga accaggtcag    2460

cctgacctgc ctggtcaaag gcttctatcc cagcgacatc gccgtggagt gggagagcaa    2520

tgggcagccg gagaacaact acaagaccac gcctcccgtg ctggactccg acggctcctt    2580

cttcctctac agcaagctca ccgtggacaa gagcaggtgg cagcagggga acgtcttctc    2640

atgctccgtg atgcatgagg ctctgcacaa ccactacacg cagaagagcc tctccctgtc    2700

tccgggtaaa taaatcgatg gcgcgcc                                        2727


<210> 20
<211> 2427
<212> DNA
<213> Artificial Sequence

<220> 
<223> IgG4 Hinge Ipilimumab

<400> 20
gctagcaagc ttgttatcca ccatggagac agacacactc ctgctatggg tactgctgct      60

ctgggttcca ggttccactg gtgacgagtc caaatatggt cccccatgcc catcatgccc     120

agttaacggc ggcggcggca gcggtcccct gggtgtgaga gcggcccagc cggccgaaat     180

tgtgttgacg cagtctccag gcaccctgtc tttgtctcca ggggaaagag ccaccctctc     240

ctgcagggcc agtcagagtg ttggcagcag ctacttagcc tggtaccagc agaaacctgg     300

ccaggctccc aggctcctca tctatggtgc attcagcagg gccactggca tcccagacag     360

gttcagtggc agtgggtctg ggacagactt cactctcacc atcagcagac tggagcctga     420

agattttgca gtgtattact gtcagcagta tggtagctca ccgtggacgt tcggccaagg     480

gaccaaggtg gaaatcaaac ggactgtggc tgcaccatct gtcttcatct tcccgccatc     540

tgatgagcag ttgaaatctg gaactgcctc tgttgtgtgc ctgctgaata acttctatcc     600

cagagaggcc aaagtacagt ggaaggtgga taacgccctc caatcgggta actcccagga     660

gagtgtcaca gagcaggaca gcaaggacag cacctacagc ctcagcagca ccctgacgct     720

gagcaaagca gactacgaga aacacaaact ctacgcctgc gaagtcaccc atcagggcct     780

gagctcgccc gtcacaaaga gcttcaacag gggagagtgc ctcgagcgag caaaacgagc     840

accagtaaaa caaacactaa acttcgacct actaaaacta gcaggagacg tagaatcaaa     900

cccaggacca gccacaacca tggagacaga cacactcctg ctatgggtac tgctgctctg     960

ggttccaggt tccactggtg acgagtccaa atatggtccc ccatgcccat catgcccagg    1020

cggccgcggc ggcggcggca gcggtcccct gggtgtgaga agatctcagg tgcagctggt    1080

ggagtctggg ggaggcgtgg tccagcctgg gaggtccctg agactctcct gtgcagcctc    1140

tggattcacc ttcagtagct atactatgca ctgggtccgc caggctccag gcaaggggct    1200

ggagtgggtg acatttatat catatgatgg aaacaataaa tactacgcag actccgtgaa    1260

gggccgattc accatctcca gagacaattc caagaacacg ctgtatctgc aaatgaacag    1320

cctgagagct gaggacacgg ctatatatta ctgtgcgagg accggctggc tggggccctt    1380

tgactactgg ggccagggaa ccctggtcac cgtctcctca gcctccacca agggaccatc    1440

ggtcttcccc ctggcaccct cctccaagag cacctctggg ggcacagcgg ccctgggctg    1500

cctggtcaag gactacttcc ccgaaccggt gacggtgtcg tggaactcag gcgccctgac    1560

cagcggcgtg cacaccttcc cggctgtcct acagtcctca ggactctact ccctcagcag    1620

cgtggtgacc gtgccctcca gcagcttggg cacccagacc tacatctgca acgtgaatca    1680

caagcccagc aacaccaagg tcgacaagaa agttgagccc aaatcttgtg acaaaactca    1740

cacatgccca ccgtgcccag cacccgaact cctgggggga ccgtcagtct tcctcttccc    1800

cccaaaaccc aaggacaccc tcatgatctc ccggacccct gaggtcacat gcgtggtggt    1860

ggacgtgagc cacgaagacc ctgaggtcaa gttcaactgg tacgtggacg gcgtggaggt    1920

gcataatgcc aagacaaagc cgcgggagga gcagtacaac agcacgtacc gtgtggtcag    1980

cgtcctcacc gtcctgcacc aggactggct gaatggcaag gagtacaagt gcaaggtctc    2040

caacaaagcc ctcccagccc ccatcgagaa aaccatctcc aaagccaagg ggcagccccg    2100

agaaccacag gtgtacaccc tgcccccatc ccgggatgag ctgaccaaga accaggtcag    2160

cctgacctgc ctggtcaaag gcttctatcc cagcgacatc gccgtggagt gggagagcaa    2220

tgggcagccg gagaacaact acaagaccac gcctcccgtg ctggactccg acggctcctt    2280

cttcctctac agcaagctca ccgtggacaa gagcaggtgg cagcagggga acgtcttctc    2340

atgctccgtg atgcatgagg ctctgcacaa ccactacacg cagaagagcc tctccctgtc    2400

tccgggtaaa taaatcgatg gcgcgcc                                        2427


<210> 21
<211> 2469
<212> DNA
<213> Artificial Sequence

<220> 
<223> IgA1 Hinge Ipilimumab

<400> 21
gctagcaagc ttgttatcca ccatggagac agacacactc ctgctatggg tactgctgct      60

ctgggttcca ggttccactg gtgacccagt tccctcaact ccacctaccc catctccctc     120

aactccacct accccatctc cctcatgctg ccacgttaac ggcggcggcg gcagcggtcc     180

cctgggtgtg agagcggccc agccggccga aattgtgttg acgcagtctc caggcaccct     240

gtctttgtct ccaggggaaa gagccaccct ctcctgcagg gccagtcaga gtgttggcag     300

cagctactta gcctggtacc agcagaaacc tggccaggct cccaggctcc tcatctatgg     360

tgcattcagc agggccactg gcatcccaga caggttcagt ggcagtgggt ctgggacaga     420

cttcactctc accatcagca gactggagcc tgaagatttt gcagtgtatt actgtcagca     480

gtatggtagc tcaccgtgga cgttcggcca agggaccaag gtggaaatca aacggactgt     540

ggctgcacca tctgtcttca tcttcccgcc atctgatgag cagttgaaat ctggaactgc     600

ctctgttgtg tgcctgctga ataacttcta tcccagagag gccaaagtac agtggaaggt     660

ggataacgcc ctccaatcgg gtaactccca ggagagtgtc acagagcagg acagcaagga     720

cagcacctac agcctcagca gcaccctgac gctgagcaaa gcagactacg agaaacacaa     780

actctacgcc tgcgaagtca cccatcaggg cctgagctcg cccgtcacaa agagcttcaa     840

caggggagag tgcctcgagc gagcaaaacg agcaccagta aaacaaacac taaacttcga     900

cctactaaaa ctagcaggag acgtagaatc aaacccagga ccagccacaa ccatggagac     960

agacacactc ctgctatggg tactgctgct ctgggttcca ggttccactg gtgacgagcc    1020

caaatcttgt gacaaaactc acacatgccc accgtgccca ggcggccgcg gcggcggcgg    1080

cagcggtccc ctgggtgtga gaagatctca ggtgcagctg gtggagtctg ggggaggcgt    1140

ggtccagcct gggaggtccc tgagactctc ctgtgcagcc tctggattca ccttcagtag    1200

ctatactatg cactgggtcc gccaggctcc aggcaagggg ctggagtggg tgacatttat    1260

atcatatgat ggaaacaata aatactacgc agactccgtg aagggccgat tcaccatctc    1320

cagagacaat tccaagaaca cgctgtatct gcaaatgaac agcctgagag ctgaggacac    1380

ggctatatat tactgtgcga ggaccggctg gctggggccc tttgactact ggggccaggg    1440

aaccctggtc accgtctcct cagcctccac caagggacca tcggtcttcc ccctggcacc    1500

ctcctccaag agcacctctg ggggcacagc ggccctgggc tgcctggtca aggactactt    1560

ccccgaaccg gtgacggtgt cgtggaactc aggcgccctg accagcggcg tgcacacctt    1620

cccggctgtc ctacagtcct caggactcta ctccctcagc agcgtggtga ccgtgccctc    1680

cagcagcttg ggcacccaga cctacatctg caacgtgaat cacaagccca gcaacaccaa    1740

ggtcgacaag aaagttgagc ccaaatcttg tgacaaaact cacacatgcc caccgtgccc    1800

agcacccgaa ctcctggggg gaccgtcagt cttcctcttc cccccaaaac ccaaggacac    1860

cctcatgatc tcccggaccc ctgaggtcac atgcgtggtg gtggacgtga gccacgaaga    1920

ccctgaggtc aagttcaact ggtacgtgga cggcgtggag gtgcataatg ccaagacaaa    1980

gccgcgggag gagcagtaca acagcacgta ccgtgtggtc agcgtcctca ccgtcctgca    2040

ccaggactgg ctgaatggca aggagtacaa gtgcaaggtc tccaacaaag ccctcccagc    2100

ccccatcgag aaaaccatct ccaaagccaa ggggcagccc cgagaaccac aggtgtacac    2160

cctgccccca tcccgggatg agctgaccaa gaaccaggtc agcctgacct gcctggtcaa    2220

aggcttctat cccagcgaca tcgccgtgga gtgggagagc aatgggcagc cggagaacaa    2280

ctacaagacc acgcctcccg tgctggactc cgacggctcc ttcttcctct acagcaagct    2340

caccgtggac aagagcaggt ggcagcaggg gaacgtcttc tcatgctccg tgatgcatga    2400

ggctctgcac aaccactaca cgcagaagag cctctccctg tctccgggta aataaatcga    2460

tggcgcgcc                                                            2469


<210> 22
<211> 2415
<212> DNA
<213> Artificial Sequence

<220> 
<223> IgA2 Hinge Ipilimumab

<400> 22
gctagcaagc ttgttatcca ccatggagac agacacactc ctgctatggg tactgctgct      60

ctgggttcca ggttccactg gtgacccagt tcccccacct cccccatgct gccacgttaa     120

cggcggcggc ggcagcggtc ccctgggtgt gagagcggcc cagccggccg aaattgtgtt     180

gacgcagtct ccaggcaccc tgtctttgtc tccaggggaa agagccaccc tctcctgcag     240

ggccagtcag agtgttggca gcagctactt agcctggtac cagcagaaac ctggccaggc     300

tcccaggctc ctcatctatg gtgcattcag cagggccact ggcatcccag acaggttcag     360

tggcagtggg tctgggacag acttcactct caccatcagc agactggagc ctgaagattt     420

tgcagtgtat tactgtcagc agtatggtag ctcaccgtgg acgttcggcc aagggaccaa     480

ggtggaaatc aaacggactg tggctgcacc atctgtcttc atcttcccgc catctgatga     540

gcagttgaaa tctggaactg cctctgttgt gtgcctgctg aataacttct atcccagaga     600

ggccaaagta cagtggaagg tggataacgc cctccaatcg ggtaactccc aggagagtgt     660

cacagagcag gacagcaagg acagcaccta cagcctcagc agcaccctga cgctgagcaa     720

agcagactac gagaaacaca aactctacgc ctgcgaagtc acccatcagg gcctgagctc     780

gcccgtcaca aagagcttca acaggggaga gtgcctcgag cgagcaaaac gagcaccagt     840

aaaacaaaca ctaaacttcg acctactaaa actagcagga gacgtagaat caaacccagg     900

accagccaca accatggaga cagacacact cctgctatgg gtactgctgc tctgggttcc     960

aggttccact ggtgacccag ttcccccacc tcccccatgc tgccacggcg gccgcggcgg    1020

cggcggcagc ggtcccctgg gtgtgagaag atctcaggtg cagctggtgg agtctggggg    1080

aggcgtggtc cagcctggga ggtccctgag actctcctgt gcagcctctg gattcacctt    1140

cagtagctat actatgcact gggtccgcca ggctccaggc aaggggctgg agtgggtgac    1200

atttatatca tatgatggaa acaataaata ctacgcagac tccgtgaagg gccgattcac    1260

catctccaga gacaattcca agaacacgct gtatctgcaa atgaacagcc tgagagctga    1320

ggacacggct atatattact gtgcgaggac cggctggctg gggccctttg actactgggg    1380

ccagggaacc ctggtcaccg tctcctcagc ctccaccaag ggaccatcgg tcttccccct    1440

ggcaccctcc tccaagagca cctctggggg cacagcggcc ctgggctgcc tggtcaagga    1500

ctacttcccc gaaccggtga cggtgtcgtg gaactcaggc gccctgacca gcggcgtgca    1560

caccttcccg gctgtcctac agtcctcagg actctactcc ctcagcagcg tggtgaccgt    1620

gccctccagc agcttgggca cccagaccta catctgcaac gtgaatcaca agcccagcaa    1680

caccaaggtc gacaagaaag ttgagcccaa atcttgtgac aaaactcaca catgcccacc    1740

gtgcccagca cccgaactcc tggggggacc gtcagtcttc ctcttccccc caaaacccaa    1800

ggacaccctc atgatctccc ggacccctga ggtcacatgc gtggtggtgg acgtgagcca    1860

cgaagaccct gaggtcaagt tcaactggta cgtggacggc gtggaggtgc ataatgccaa    1920

gacaaagccg cgggaggagc agtacaacag cacgtaccgt gtggtcagcg tcctcaccgt    1980

cctgcaccag gactggctga atggcaagga gtacaagtgc aaggtctcca acaaagccct    2040

cccagccccc atcgagaaaa ccatctccaa agccaagggg cagccccgag aaccacaggt    2100

gtacaccctg cccccatccc gggatgagct gaccaagaac caggtcagcc tgacctgcct    2160

ggtcaaaggc ttctatccca gcgacatcgc cgtggagtgg gagagcaatg ggcagccgga    2220

gaacaactac aagaccacgc ctcccgtgct ggactccgac ggctccttct tcctctacag    2280

caagctcacc gtggacaaga gcaggtggca gcaggggaac gtcttctcat gctccgtgat    2340

gcatgaggct ctgcacaacc actacacgca gaagagcctc tccctgtctc cgggtaaata    2400

aatcgatggc gcgcc                                                     2415


<210> 23
<211> 2451
<212> DNA
<213> Artificial Sequence

<220> 
<223> IgG1 Hinge Ticilimumab

<400> 23
gctagcaagc ttgttatcca ccatggagac agacacactc ctgctatggg tactgctgct      60

ctgggttcca ggttccactg gtgacgagcc caaatcttgt gacaaaactc acacatgccc     120

accgtgccca gttaacggcg gcggcggcag cggtcccctg ggtgtgagag cggcccagcc     180

ggccgacatc cagatgaccc agtctccatc ctccctgtct gcatctgtag gagacagagt     240

caccatcact tgccgggcaa gtcagagcat taacagctat ttagattggt atcagcagaa     300

accagggaaa gcccctaagc tcctgatcta tgctgcatcc agtttgcaaa gtggggtccc     360

atcaaggttc agtggcagtg gatctgggac agatttcact ctcaccatca gcagtctgca     420

acctgaagat tttgcaactt actactgtca acagtattac agtaccccat tcactttcgg     480

ccctgggacc aaagtggaaa tcaaacgaac tgtggctgca ccatctgtct tcatcttccc     540

gccatctgat gagcagttga aatctggaac tgcctctgtt gtgtgcctgc tgaataactt     600

ctatcccaga gaggccaaag tacagtggaa ggtggataac gccctccaat cgggtaactc     660

ccaggagagt gtcacagagc aggacagcaa ggacagcacc tacagcctca gcagcaccct     720

gacgctgagc aaagcagact acgagaaaca caaactctac gcctgcgaag tcacccatca     780

gggcctgagc tcgcccgtca caaagagctt caacagggga gagtgcctcg agcgagcaaa     840

acgagcacca gtaaaacaaa cactaaactt cgacctacta aaactagcag gagacgtaga     900

atcaaaccca ggaccagcca caaccatgga gacagacaca ctcctgctat gggtactgct     960

gctctgggtt ccaggttcca ctggtgacga gcccaaatct tgtgacaaaa ctcacacatg    1020

cccaccgtgc ccaggcggcc gcggcggcgg cggcagcggt cccctgggtg tgagaagatc    1080

tcaggtgcag ctggtggagt ctgggggagg cgtggtccaa ccggggcggt ccctgagact    1140

ctcctgtgca gcctctggat tcaccttcag tagctatggc atgcactggg tccgccaggc    1200

tccagggaag gggctggagt gggtcgcagt tatttggtat gacggaagta acaaatatta    1260

tgcagactca gtgaagggcc gattcaccat ctccagagac aactccaaga acacactgta    1320

tctgcaaatg aacagcctga gagccgagga cacggctgtg tattactgtg cgagagatcc    1380

tcgcggggca acactctact actactacta cgggatggac gtctggggcc agggaaccac    1440

ggtcaccgtc tcttcagcct ccaccaaggg cccatcggtc ttccccctgg cgccctgctc    1500

caggagcacc tccgagagca cagcggccct gggctgcctg gtcaaggact acttccccga    1560

accggtgacg gtgtcgtgga actcaggcgc tctgaccagc ggcgtgcaca ccttcccagc    1620

tgtcctacag tcctcaggac tctactccct cagcagcgtg gtgaccgtgc cctccagcaa    1680

cttcggcacc cagacctaca cctgcaacgt agatcacaag cccagcaaca ccaaggtcga    1740

caagacagtt gagcgcaaat gttgtgtcga gtgcccaccg tgcccagcac cacctgtggc    1800

aggaccgtca gtcttcctct tccccccaaa acccaaggac accctcatga tctcccggac    1860

ccctgaggtc acgtgcgtgg tggtggacgt gagccacgaa gaccccgagg tccagttcaa    1920

ctggtacgtg gacggcgtgg aggtgcataa tgccaagaca aagccacggg aggagcagtt    1980

caacagcacg ttccgtgtgg tcagcgtcct caccgtcgtg caccaggact ggctgaacgg    2040

caaggagtac aagtgcaagg tctccaacaa aggcctccca gcccccatcg agaaaaccat    2100

ctccaaaacc aaagggcagc cccgagaacc acaggtgtac accctgcccc catcccggga    2160

ggagatgacc aagaaccagg tcagcctgac ctgcctggtc aaaggcttct accccagcga    2220

catcgccgtg gagtgggaga gcaatgggca gccggagaac aactacaaga ccacacctcc    2280

catgctggac tccgacggct ccttcttcct ctacagcaag ctcaccgtgg acaagagcag    2340

gtggcagcag gggaacgtct tctcatgctc cgtgatgcat gaggctctgc acaaccacta    2400

cacacagaag agcctctccc tgtctccggg taaataaatc gatggcgcgc c             2451


<210> 24
<211> 2433
<212> DNA
<213> Artificial Sequence

<220> 
<223> IgG2 Hinge Ticilimumab

<400> 24
gctagcaagc ttgttatcca ccatggagac agacacactc ctgctatggg tactgctgct      60

ctgggttcca ggttccactg gtgacgagcg caaatgttgt gtcgagtgcc caccgtgccc     120

agttaacggc ggcggcggca gcggtcccct gggtgtgaga gcggcccagc cggccgacat     180

ccagatgacc cagtctccat cctccctgtc tgcatctgta ggagacagag tcaccatcac     240

ttgccgggca agtcagagca ttaacagcta tttagattgg tatcagcaga aaccagggaa     300

agcccctaag ctcctgatct atgctgcatc cagtttgcaa agtggggtcc catcaaggtt     360

cagtggcagt ggatctggga cagatttcac tctcaccatc agcagtctgc aacctgaaga     420

ttttgcaact tactactgtc aacagtatta cagtacccca ttcactttcg gccctgggac     480

caaagtggaa atcaaacgaa ctgtggctgc accatctgtc ttcatcttcc cgccatctga     540

tgagcagttg aaatctggaa ctgcctctgt tgtgtgcctg ctgaataact tctatcccag     600

agaggccaaa gtacagtgga aggtggataa cgccctccaa tcgggtaact cccaggagag     660

tgtcacagag caggacagca aggacagcac ctacagcctc agcagcaccc tgacgctgag     720

caaagcagac tacgagaaac acaaactcta cgcctgcgaa gtcacccatc agggcctgag     780

ctcgcccgtc acaaagagct tcaacagggg agagtgcctc gagcgagcaa aacgagcacc     840

agtaaaacaa acactaaact tcgacctact aaaactagca ggagacgtag aatcaaaccc     900

aggaccagcc acaaccatgg agacagacac actcctgcta tgggtactgc tgctctgggt     960

tccaggttcc actggtgacg agcgcaaatg ttgtgtcgag tgcccaccgt gcccaggcgg    1020

ccgcggcggc ggcggcagcg gtcccctggg tgtgagaaga tctcaggtgc agctggtgga    1080

gtctggggga ggcgtggtcc aaccggggcg gtccctgaga ctctcctgtg cagcctctgg    1140

attcaccttc agtagctatg gcatgcactg ggtccgccag gctccaggga aggggctgga    1200

gtgggtcgca gttatttggt atgacggaag taacaaatat tatgcagact cagtgaaggg    1260

ccgattcacc atctccagag acaactccaa gaacacactg tatctgcaaa tgaacagcct    1320

gagagccgag gacacggctg tgtattactg tgcgagagat cctcgcgggg caacactcta    1380

ctactactac tacgggatgg acgtctgggg ccagggaacc acggtcaccg tctcttcagc    1440

ctccaccaag ggcccatcgg tcttccccct ggcgccctgc tccaggagca cctccgagag    1500

cacagcggcc ctgggctgcc tggtcaagga ctacttcccc gaaccggtga cggtgtcgtg    1560

gaactcaggc gctctgacca gcggcgtgca caccttccca gctgtcctac agtcctcagg    1620

actctactcc ctcagcagcg tggtgaccgt gccctccagc aacttcggca cccagaccta    1680

cacctgcaac gtagatcaca agcccagcaa caccaaggtc gacaagacag ttgagcgcaa    1740

atgttgtgtc gagtgcccac cgtgcccagc accacctgtg gcaggaccgt cagtcttcct    1800

cttcccccca aaacccaagg acaccctcat gatctcccgg acccctgagg tcacgtgcgt    1860

ggtggtggac gtgagccacg aagaccccga ggtccagttc aactggtacg tggacggcgt    1920

ggaggtgcat aatgccaaga caaagccacg ggaggagcag ttcaacagca cgttccgtgt    1980

ggtcagcgtc ctcaccgtcg tgcaccagga ctggctgaac ggcaaggagt acaagtgcaa    2040

ggtctccaac aaaggcctcc cagcccccat cgagaaaacc atctccaaaa ccaaagggca    2100

gccccgagaa ccacaggtgt acaccctgcc cccatcccgg gaggagatga ccaagaacca    2160

ggtcagcctg acctgcctgg tcaaaggctt ctaccccagc gacatcgccg tggagtggga    2220

gagcaatggg cagccggaga acaactacaa gaccacacct cccatgctgg actccgacgg    2280

ctccttcttc ctctacagca agctcaccgt ggacaagagc aggtggcagc aggggaacgt    2340

cttctcatgc tccgtgatgc atgaggctct gcacaaccac tacacacaga agagcctctc    2400

cctgtctccg ggtaaataaa tcgatggcgc gcc                                 2433


<210> 25
<211> 2733
<212> DNA
<213> Artificial Sequence

<220> 
<223> IgG3 Hinge Ticilimumab

<400> 25
gctagcaagc ttgttatcca ccatggagac agacacactc ctgctatggg tactgctgct      60

ctgggttcca ggttccactg gtgacgagct caaaacccca cttggtgaca caactcacac     120

atgcccacgg tgcccagagc ccaaatcttg tgacacacct cccccgtgcc cacggtgccc     180

agagcccaaa tcttgtgaca cacctccccc atgcccacgg tgcccagagc ccaaatcttg     240

tgacacacct cccccgtgcc caaggtgccc agttaacggc ggcggcggca gcggtcccct     300

gggtgtgaga gcggcccagc cggccgacat ccagatgacc cagtctccat cctccctgtc     360

tgcatctgta ggagacagag tcaccatcac ttgccgggca agtcagagca ttaacagcta     420

tttagattgg tatcagcaga aaccagggaa agcccctaag ctcctgatct atgctgcatc     480

cagtttgcaa agtggggtcc catcaaggtt cagtggcagt ggatctggga cagatttcac     540

tctcaccatc agcagtctgc aacctgaaga ttttgcaact tactactgtc aacagtatta     600

cagtacccca ttcactttcg gccctgggac caaagtggaa atcaaacgaa ctgtggctgc     660

accatctgtc ttcatcttcc cgccatctga tgagcagttg aaatctggaa ctgcctctgt     720

tgtgtgcctg ctgaataact tctatcccag agaggccaaa gtacagtgga aggtggataa     780

cgccctccaa tcgggtaact cccaggagag tgtcacagag caggacagca aggacagcac     840

ctacagcctc agcagcaccc tgacgctgag caaagcagac tacgagaaac acaaactcta     900

cgcctgcgaa gtcacccatc agggcctgag ctcgcccgtc acaaagagct tcaacagggg     960

agagtgcctc gagcgagcaa aacgagcacc agtaaaacaa acactaaact tcgacctact    1020

aaaactagca ggagacgtag aatcaaaccc aggaccagcc acaaccatgg agacagacac    1080

actcctgcta tgggtactgc tgctctgggt tccaggttcc actggtgacg agctcaaaac    1140

cccacttggt gacacaactc acacatgccc acggtgccca gagcccaaat cttgtgacac    1200

acctcccccg tgcccacggt gcccagagcc caaatcttgt gacacacctc ccccatgccc    1260

acggtgccca gagcccaaat cttgtgacac acctcccccg tgcccaaggt gcccaggcgg    1320

ccgcggcggc ggcggcagcg gtcccctggg tgtgagaaga tctcaggtgc agctggtgga    1380

gtctggggga ggcgtggtcc aaccggggcg gtccctgaga ctctcctgtg cagcctctgg    1440

attcaccttc agtagctatg gcatgcactg ggtccgccag gctccaggga aggggctgga    1500

gtgggtcgca gttatttggt atgacggaag taacaaatat tatgcagact cagtgaaggg    1560

ccgattcacc atctccagag acaactccaa gaacacactg tatctgcaaa tgaacagcct    1620

gagagccgag gacacggctg tgtattactg tgcgagagat cctcgcgggg caacactcta    1680

ctactactac tacgggatgg acgtctgggg ccagggaacc acggtcaccg tctcttcagc    1740

ctccaccaag ggcccatcgg tcttccccct ggcgccctgc tccaggagca cctccgagag    1800

cacagcggcc ctgggctgcc tggtcaagga ctacttcccc gaaccggtga cggtgtcgtg    1860

gaactcaggc gctctgacca gcggcgtgca caccttccca gctgtcctac agtcctcagg    1920

actctactcc ctcagcagcg tggtgaccgt gccctccagc aacttcggca cccagaccta    1980

cacctgcaac gtagatcaca agcccagcaa caccaaggtc gacaagacag ttgagcgcaa    2040

atgttgtgtc gagtgcccac cgtgcccagc accacctgtg gcaggaccgt cagtcttcct    2100

cttcccccca aaacccaagg acaccctcat gatctcccgg acccctgagg tcacgtgcgt    2160

ggtggtggac gtgagccacg aagaccccga ggtccagttc aactggtacg tggacggcgt    2220

ggaggtgcat aatgccaaga caaagccacg ggaggagcag ttcaacagca cgttccgtgt    2280

ggtcagcgtc ctcaccgtcg tgcaccagga ctggctgaac ggcaaggagt acaagtgcaa    2340

ggtctccaac aaaggcctcc cagcccccat cgagaaaacc atctccaaaa ccaaagggca    2400

gccccgagaa ccacaggtgt acaccctgcc cccatcccgg gaggagatga ccaagaacca    2460

ggtcagcctg acctgcctgg tcaaaggctt ctaccccagc gacatcgccg tggagtggga    2520

gagcaatggg cagccggaga acaactacaa gaccacacct cccatgctgg actccgacgg    2580

ctccttcttc ctctacagca agctcaccgt ggacaagagc aggtggcagc aggggaacgt    2640

cttctcatgc tccgtgatgc atgaggctct gcacaaccac tacacacaga agagcctctc    2700

cctgtctccg ggtaaataaa tcgatggcgc gcc                                 2733


<210> 26
<211> 2433
<212> DNA
<213> Artificial Sequence

<220> 
<223> IgG4 Hinge Ticilimumab

<400> 26
gctagcaagc ttgttatcca ccatggagac agacacactc ctgctatggg tactgctgct      60

ctgggttcca ggttccactg gtgacgagtc caaatatggt cccccatgcc catcatgccc     120

agttaacggc ggcggcggca gcggtcccct gggtgtgaga gcggcccagc cggccgacat     180

ccagatgacc cagtctccat cctccctgtc tgcatctgta ggagacagag tcaccatcac     240

ttgccgggca agtcagagca ttaacagcta tttagattgg tatcagcaga aaccagggaa     300

agcccctaag ctcctgatct atgctgcatc cagtttgcaa agtggggtcc catcaaggtt     360

cagtggcagt ggatctggga cagatttcac tctcaccatc agcagtctgc aacctgaaga     420

ttttgcaact tactactgtc aacagtatta cagtacccca ttcactttcg gccctgggac     480

caaagtggaa atcaaacgaa ctgtggctgc accatctgtc ttcatcttcc cgccatctga     540

tgagcagttg aaatctggaa ctgcctctgt tgtgtgcctg ctgaataact tctatcccag     600

agaggccaaa gtacagtgga aggtggataa cgccctccaa tcgggtaact cccaggagag     660

tgtcacagag caggacagca aggacagcac ctacagcctc agcagcaccc tgacgctgag     720

caaagcagac tacgagaaac acaaactcta cgcctgcgaa gtcacccatc agggcctgag     780

ctcgcccgtc acaaagagct tcaacagggg agagtgcctc gagcgagcaa aacgagcacc     840

agtaaaacaa acactaaact tcgacctact aaaactagca ggagacgtag aatcaaaccc     900

aggaccagcc acaaccatgg agacagacac actcctgcta tgggtactgc tgctctgggt     960

tccaggttcc actggtgacg agtccaaata tggtccccca tgcccatcat gcccaggcgg    1020

ccgcggcggc ggcggcagcg gtcccctggg tgtgagaaga tctcaggtgc agctggtgga    1080

gtctggggga ggcgtggtcc aaccggggcg gtccctgaga ctctcctgtg cagcctctgg    1140

attcaccttc agtagctatg gcatgcactg ggtccgccag gctccaggga aggggctgga    1200

gtgggtcgca gttatttggt atgacggaag taacaaatat tatgcagact cagtgaaggg    1260

ccgattcacc atctccagag acaactccaa gaacacactg tatctgcaaa tgaacagcct    1320

gagagccgag gacacggctg tgtattactg tgcgagagat cctcgcgggg caacactcta    1380

ctactactac tacgggatgg acgtctgggg ccagggaacc acggtcaccg tctcttcagc    1440

ctccaccaag ggcccatcgg tcttccccct ggcgccctgc tccaggagca cctccgagag    1500

cacagcggcc ctgggctgcc tggtcaagga ctacttcccc gaaccggtga cggtgtcgtg    1560

gaactcaggc gctctgacca gcggcgtgca caccttccca gctgtcctac agtcctcagg    1620

actctactcc ctcagcagcg tggtgaccgt gccctccagc aacttcggca cccagaccta    1680

cacctgcaac gtagatcaca agcccagcaa caccaaggtc gacaagacag ttgagcgcaa    1740

atgttgtgtc gagtgcccac cgtgcccagc accacctgtg gcaggaccgt cagtcttcct    1800

cttcccccca aaacccaagg acaccctcat gatctcccgg acccctgagg tcacgtgcgt    1860

ggtggtggac gtgagccacg aagaccccga ggtccagttc aactggtacg tggacggcgt    1920

ggaggtgcat aatgccaaga caaagccacg ggaggagcag ttcaacagca cgttccgtgt    1980

ggtcagcgtc ctcaccgtcg tgcaccagga ctggctgaac ggcaaggagt acaagtgcaa    2040

ggtctccaac aaaggcctcc cagcccccat cgagaaaacc atctccaaaa ccaaagggca    2100

gccccgagaa ccacaggtgt acaccctgcc cccatcccgg gaggagatga ccaagaacca    2160

ggtcagcctg acctgcctgg tcaaaggctt ctaccccagc gacatcgccg tggagtggga    2220

gagcaatggg cagccggaga acaactacaa gaccacacct cccatgctgg actccgacgg    2280

ctccttcttc ctctacagca agctcaccgt ggacaagagc aggtggcagc aggggaacgt    2340

cttctcatgc tccgtgatgc atgaggctct gcacaaccac tacacacaga agagcctctc    2400

cctgtctccg ggtaaataaa tcgatggcgc gcc                                 2433


<210> 27
<211> 2475
<212> DNA
<213> Artificial Sequence

<220> 
<223> IgA1 Hinge Ticilimumab

<400> 27
gctagcaagc ttgttatcca ccatggagac agacacactc ctgctatggg tactgctgct      60

ctgggttcca ggttccactg gtgacccagt tccctcaact ccacctaccc catctccctc     120

aactccacct accccatctc cctcatgctg ccacgttaac ggcggcggcg gcagcggtcc     180

cctgggtgtg agagcggccc agccggccga catccagatg acccagtctc catcctccct     240

gtctgcatct gtaggagaca gagtcaccat cacttgccgg gcaagtcaga gcattaacag     300

ctatttagat tggtatcagc agaaaccagg gaaagcccct aagctcctga tctatgctgc     360

atccagtttg caaagtgggg tcccatcaag gttcagtggc agtggatctg ggacagattt     420

cactctcacc atcagcagtc tgcaacctga agattttgca acttactact gtcaacagta     480

ttacagtacc ccattcactt tcggccctgg gaccaaagtg gaaatcaaac gaactgtggc     540

tgcaccatct gtcttcatct tcccgccatc tgatgagcag ttgaaatctg gaactgcctc     600

tgttgtgtgc ctgctgaata acttctatcc cagagaggcc aaagtacagt ggaaggtgga     660

taacgccctc caatcgggta actcccagga gagtgtcaca gagcaggaca gcaaggacag     720

cacctacagc ctcagcagca ccctgacgct gagcaaagca gactacgaga aacacaaact     780

ctacgcctgc gaagtcaccc atcagggcct gagctcgccc gtcacaaaga gcttcaacag     840

gggagagtgc ctcgagcgag caaaacgagc accagtaaaa caaacactaa acttcgacct     900

actaaaacta gcaggagacg tagaatcaaa cccaggacca gccacaacca tggagacaga     960

cacactcctg ctatgggtac tgctgctctg ggttccaggt tccactggtg acgagcccaa    1020

atcttgtgac aaaactcaca catgcccacc gtgcccaggc ggccgcggcg gcggcggcag    1080

cggtcccctg ggtgtgagaa gatctcaggt gcagctggtg gagtctgggg gaggcgtggt    1140

ccaaccgggg cggtccctga gactctcctg tgcagcctct ggattcacct tcagtagcta    1200

tggcatgcac tgggtccgcc aggctccagg gaaggggctg gagtgggtcg cagttatttg    1260

gtatgacgga agtaacaaat attatgcaga ctcagtgaag ggccgattca ccatctccag    1320

agacaactcc aagaacacac tgtatctgca aatgaacagc ctgagagccg aggacacggc    1380

tgtgtattac tgtgcgagag atcctcgcgg ggcaacactc tactactact actacgggat    1440

ggacgtctgg ggccagggaa ccacggtcac cgtctcttca gcctccacca agggcccatc    1500

ggtcttcccc ctggcgccct gctccaggag cacctccgag agcacagcgg ccctgggctg    1560

cctggtcaag gactacttcc ccgaaccggt gacggtgtcg tggaactcag gcgctctgac    1620

cagcggcgtg cacaccttcc cagctgtcct acagtcctca ggactctact ccctcagcag    1680

cgtggtgacc gtgccctcca gcaacttcgg cacccagacc tacacctgca acgtagatca    1740

caagcccagc aacaccaagg tcgacaagac agttgagcgc aaatgttgtg tcgagtgccc    1800

accgtgccca gcaccacctg tggcaggacc gtcagtcttc ctcttccccc caaaacccaa    1860

ggacaccctc atgatctccc ggacccctga ggtcacgtgc gtggtggtgg acgtgagcca    1920

cgaagacccc gaggtccagt tcaactggta cgtggacggc gtggaggtgc ataatgccaa    1980

gacaaagcca cgggaggagc agttcaacag cacgttccgt gtggtcagcg tcctcaccgt    2040

cgtgcaccag gactggctga acggcaagga gtacaagtgc aaggtctcca acaaaggcct    2100

cccagccccc atcgagaaaa ccatctccaa aaccaaaggg cagccccgag aaccacaggt    2160

gtacaccctg cccccatccc gggaggagat gaccaagaac caggtcagcc tgacctgcct    2220

ggtcaaaggc ttctacccca gcgacatcgc cgtggagtgg gagagcaatg ggcagccgga    2280

gaacaactac aagaccacac ctcccatgct ggactccgac ggctccttct tcctctacag    2340

caagctcacc gtggacaaga gcaggtggca gcaggggaac gtcttctcat gctccgtgat    2400

gcatgaggct ctgcacaacc actacacaca gaagagcctc tccctgtctc cgggtaaata    2460

aatcgatggc gcgcc                                                     2475


<210> 28
<211> 2421
<212> DNA
<213> Artificial Sequence

<220> 
<223> IgA2 Hinge Ticilimumab

<400> 28
gctagcaagc ttgttatcca ccatggagac agacacactc ctgctatggg tactgctgct      60

ctgggttcca ggttccactg gtgacccagt tcccccacct cccccatgct gccacgttaa     120

cggcggcggc ggcagcggtc ccctgggtgt gagagcggcc cagccggccg acatccagat     180

gacccagtct ccatcctccc tgtctgcatc tgtaggagac agagtcacca tcacttgccg     240

ggcaagtcag agcattaaca gctatttaga ttggtatcag cagaaaccag ggaaagcccc     300

taagctcctg atctatgctg catccagttt gcaaagtggg gtcccatcaa ggttcagtgg     360

cagtggatct gggacagatt tcactctcac catcagcagt ctgcaacctg aagattttgc     420

aacttactac tgtcaacagt attacagtac cccattcact ttcggccctg ggaccaaagt     480

ggaaatcaaa cgaactgtgg ctgcaccatc tgtcttcatc ttcccgccat ctgatgagca     540

gttgaaatct ggaactgcct ctgttgtgtg cctgctgaat aacttctatc ccagagaggc     600

caaagtacag tggaaggtgg ataacgccct ccaatcgggt aactcccagg agagtgtcac     660

agagcaggac agcaaggaca gcacctacag cctcagcagc accctgacgc tgagcaaagc     720

agactacgag aaacacaaac tctacgcctg cgaagtcacc catcagggcc tgagctcgcc     780

cgtcacaaag agcttcaaca ggggagagtg cctcgagcga gcaaaacgag caccagtaaa     840

acaaacacta aacttcgacc tactaaaact agcaggagac gtagaatcaa acccaggacc     900

agccacaacc atggagacag acacactcct gctatgggta ctgctgctct gggttccagg     960

ttccactggt gacccagttc ccccacctcc cccatgctgc cacggcggcc gcggcggcgg    1020

cggcagcggt cccctgggtg tgagaagatc tcaggtgcag ctggtggagt ctgggggagg    1080

cgtggtccaa ccggggcggt ccctgagact ctcctgtgca gcctctggat tcaccttcag    1140

tagctatggc atgcactggg tccgccaggc tccagggaag gggctggagt gggtcgcagt    1200

tatttggtat gacggaagta acaaatatta tgcagactca gtgaagggcc gattcaccat    1260

ctccagagac aactccaaga acacactgta tctgcaaatg aacagcctga gagccgagga    1320

cacggctgtg tattactgtg cgagagatcc tcgcggggca acactctact actactacta    1380

cgggatggac gtctggggcc agggaaccac ggtcaccgtc tcttcagcct ccaccaaggg    1440

cccatcggtc ttccccctgg cgccctgctc caggagcacc tccgagagca cagcggccct    1500

gggctgcctg gtcaaggact acttccccga accggtgacg gtgtcgtgga actcaggcgc    1560

tctgaccagc ggcgtgcaca ccttcccagc tgtcctacag tcctcaggac tctactccct    1620

cagcagcgtg gtgaccgtgc cctccagcaa cttcggcacc cagacctaca cctgcaacgt    1680

agatcacaag cccagcaaca ccaaggtcga caagacagtt gagcgcaaat gttgtgtcga    1740

gtgcccaccg tgcccagcac cacctgtggc aggaccgtca gtcttcctct tccccccaaa    1800

acccaaggac accctcatga tctcccggac ccctgaggtc acgtgcgtgg tggtggacgt    1860

gagccacgaa gaccccgagg tccagttcaa ctggtacgtg gacggcgtgg aggtgcataa    1920

tgccaagaca aagccacggg aggagcagtt caacagcacg ttccgtgtgg tcagcgtcct    1980

caccgtcgtg caccaggact ggctgaacgg caaggagtac aagtgcaagg tctccaacaa    2040

aggcctccca gcccccatcg agaaaaccat ctccaaaacc aaagggcagc cccgagaacc    2100

acaggtgtac accctgcccc catcccggga ggagatgacc aagaaccagg tcagcctgac    2160

ctgcctggtc aaaggcttct accccagcga catcgccgtg gagtgggaga gcaatgggca    2220

gccggagaac aactacaaga ccacacctcc catgctggac tccgacggct ccttcttcct    2280

ctacagcaag ctcaccgtgg acaagagcag gtggcagcag gggaacgtct tctcatgctc    2340

cgtgatgcat gaggctctgc acaaccacta cacacagaag agcctctccc tgtctccggg    2400

taaataaatc gatggcgcgc c                                              2421


<210> 29
<211> 2451
<212> DNA
<213> Artificial Sequence

<220> 
<223> IgG1 Hinge Humira

<400> 29
gctagcaagc ttgttatcca ccatggagac agacacactc ctgctatggg tactgctgct      60

ctgggttcca ggttccactg gtgacgagcc caaatcttgt gacaaaactc acacatgccc     120

accgtgccca gttaacggcg gcggcggcag cggtcccctg ggtgtgagag cggcccagcc     180

ggccgacatc cagatgaccc agagccccag cagcctgagc gccagcgtgg gcgacagagt     240

gaccatcacc tgcagagcca gccagggcat cagaaactac ctggcctggt accagcagaa     300

gcccggcaag gcccccaagc tgctgatcta cgccgccagc accctgcaga gcggcgtgcc     360

cagcagattc agcggcagcg gcagcggcac cgacttcacc ctgaccatca gcagcctgca     420

gcccgaggac gtggccacct actactgcca gagatacaac agagccccct acaccttcgg     480

ccagggcacc aaggtggaga tcaagagaac tgtggctgca ccatctgtct tcatcttccc     540

gccatctgat gagcagttga aatctggaac tgcctctgtt gtgtgcctgc tgaataactt     600

ctatcccaga gaggccaaag tacagtggaa ggtggataac gccctccaat cgggtaactc     660

ccaggagagt gtcacagagc aggacagcaa ggacagcacc tacagcctca gcagcaccct     720

gacgctgagc aaagcagact acgagaaaca caaactctac gcctgcgaag tcacccatca     780

gggcctgagc tcgcccgtca caaagagctt caacagggga gagtgcctcg agcgagcaaa     840

acgagcacca gtaaaacaaa cactaaactt cgacctacta aaactagcag gagacgtaga     900

atcaaaccca ggaccagcca caaccatgga gacagacaca ctcctgctat gggtactgct     960

gctctgggtt ccaggttcca ctggtgacga gcccaaatct tgtgacaaaa ctcacacatg    1020

cccaccgtgc ccaggcggcc gcggcggcgg cggcagcggt cccctgggtg tgagaagatc    1080

tgaggtgcag ctggtggaga gcggcggcgg cctggtgcag cccggcagaa gcctgagact    1140

gagctgcgcc gccagcggct tcaccttcga cgactacgcc atgcactggg tgagacaggc    1200

ccccggcaag ggcctggagt gggtgagcgc catcacctgg aacagcggcc acatcgacta    1260

cgccgacagc gtggagggca gattcaccat cagcagagac aacgccaaga acagcctgta    1320

cctgcagatg aacagcctga gagccgagga caccgccgtg tactactgcg ccaaggtgag    1380

ctacctgagc accgccagca gcctggacta ctggggccag ggcaccctgg tgaccgtgag    1440

cagcgcctcc accaagggac catcggtctt ccccctggca ccctcctcca agagcacctc    1500

tgggggcaca gcggccctgg gctgcctggt caaggactac ttccccgaac cggtgacggt    1560

gtcgtggaac tcaggcgccc tgaccagcgg cgtgcacacc ttcccggctg tcctacagtc    1620

ctcaggactc tactccctca gcagcgtggt gaccgtgccc tccagcagct tgggcaccca    1680

gacctacatc tgcaacgtga atcacaagcc cagcaacacc aaggtcgaca agaaagttga    1740

gcccaaatct tgtgacaaaa ctcacacatg cccaccgtgc ccagcacctg aactcctggg    1800

gggaccgtca gtcttcctct tccccccaaa acccaaggac accctcatga tctcccggac    1860

ccctgaggtc acatgcgtgg tggtggacgt gagccacgaa gaccctgagg tcaagttcaa    1920

ctggtacgtg gacggcgtgg aggtgcataa tgccaagaca aagccgcggg aggagcagta    1980

caacagcacg taccgggtgg tcagcgtcct caccgtcctg caccaggact ggctgaatgg    2040

caaggagtac aagtgcaagg tctccaacaa agccctccca gcccccatcg agaaaaccat    2100

ctccaaagcc aaagggcagc cccgagaacc acaggtgtac accctgcccc catcccggga    2160

tgagctgacc aagaaccagg tcagcctgac ctgcctggtc aaaggcttct atcccagcga    2220

catcgccgtg gagtgggaga gcaatgggca gccggagaac aactacaaga ccacgcctcc    2280

cgtgctggac tccgacggct ccttcttcct ctacagcaag ctcaccgtgg acaagagcag    2340

gtggcagcag gggaacgtct tctcatgctc cgtgatgcat gaggctctgc acaaccacta    2400

cacgcagaag agcctctccc tgtctccggg taaataaatc gatggcgcgc c             2451


<210> 30
<211> 2433
<212> DNA
<213> Artificial Sequence

<220> 
<223> IgG2 Hinge Humira

<400> 30
gctagcaagc ttgttatcca ccatggagac agacacactc ctgctatggg tactgctgct      60

ctgggttcca ggttccactg gtgacgagcg caaatgttgt gtcgagtgcc caccgtgccc     120

agttaacggc ggcggcggca gcggtcccct gggtgtgaga gcggcccagc cggccgacat     180

ccagatgacc cagagcccca gcagcctgag cgccagcgtg ggcgacagag tgaccatcac     240

ctgcagagcc agccagggca tcagaaacta cctggcctgg taccagcaga agcccggcaa     300

ggcccccaag ctgctgatct acgccgccag caccctgcag agcggcgtgc ccagcagatt     360

cagcggcagc ggcagcggca ccgacttcac cctgaccatc agcagcctgc agcccgagga     420

cgtggccacc tactactgcc agagatacaa cagagccccc tacaccttcg gccagggcac     480

caaggtggag atcaagagaa ctgtggctgc accatctgtc ttcatcttcc cgccatctga     540

tgagcagttg aaatctggaa ctgcctctgt tgtgtgcctg ctgaataact tctatcccag     600

agaggccaaa gtacagtgga aggtggataa cgccctccaa tcgggtaact cccaggagag     660

tgtcacagag caggacagca aggacagcac ctacagcctc agcagcaccc tgacgctgag     720

caaagcagac tacgagaaac acaaactcta cgcctgcgaa gtcacccatc agggcctgag     780

ctcgcccgtc acaaagagct tcaacagggg agagtgcctc gagcgagcaa aacgagcacc     840

agtaaaacaa acactaaact tcgacctact aaaactagca ggagacgtag aatcaaaccc     900

aggaccagcc acaaccatgg agacagacac actcctgcta tgggtactgc tgctctgggt     960

tccaggttcc actggtgacg agcgcaaatg ttgtgtcgag tgcccaccgt gcccaggcgg    1020

ccgcggcggc ggcggcagcg gtcccctggg tgtgagaaga tctgaggtgc agctggtgga    1080

gagcggcggc ggcctggtgc agcccggcag aagcctgaga ctgagctgcg ccgccagcgg    1140

cttcaccttc gacgactacg ccatgcactg ggtgagacag gcccccggca agggcctgga    1200

gtgggtgagc gccatcacct ggaacagcgg ccacatcgac tacgccgaca gcgtggaggg    1260

cagattcacc atcagcagag acaacgccaa gaacagcctg tacctgcaga tgaacagcct    1320

gagagccgag gacaccgccg tgtactactg cgccaaggtg agctacctga gcaccgccag    1380

cagcctggac tactggggcc agggcaccct ggtgaccgtg agcagcgcct ccaccaaggg    1440

accatcggtc ttccccctgg caccctcctc caagagcacc tctgggggca cagcggccct    1500

gggctgcctg gtcaaggact acttccccga accggtgacg gtgtcgtgga actcaggcgc    1560

cctgaccagc ggcgtgcaca ccttcccggc tgtcctacag tcctcaggac tctactccct    1620

cagcagcgtg gtgaccgtgc cctccagcag cttgggcacc cagacctaca tctgcaacgt    1680

gaatcacaag cccagcaaca ccaaggtcga caagaaagtt gagcccaaat cttgtgacaa    1740

aactcacaca tgcccaccgt gcccagcacc tgaactcctg gggggaccgt cagtcttcct    1800

cttcccccca aaacccaagg acaccctcat gatctcccgg acccctgagg tcacatgcgt    1860

ggtggtggac gtgagccacg aagaccctga ggtcaagttc aactggtacg tggacggcgt    1920

ggaggtgcat aatgccaaga caaagccgcg ggaggagcag tacaacagca cgtaccgggt    1980

ggtcagcgtc ctcaccgtcc tgcaccagga ctggctgaat ggcaaggagt acaagtgcaa    2040

ggtctccaac aaagccctcc cagcccccat cgagaaaacc atctccaaag ccaaagggca    2100

gccccgagaa ccacaggtgt acaccctgcc cccatcccgg gatgagctga ccaagaacca    2160

ggtcagcctg acctgcctgg tcaaaggctt ctatcccagc gacatcgccg tggagtggga    2220

gagcaatggg cagccggaga acaactacaa gaccacgcct cccgtgctgg actccgacgg    2280

ctccttcttc ctctacagca agctcaccgt ggacaagagc aggtggcagc aggggaacgt    2340

cttctcatgc tccgtgatgc atgaggctct gcacaaccac tacacgcaga agagcctctc    2400

cctgtctccg ggtaaataaa tcgatggcgc gcc                                 2433


<210> 31
<211> 2732
<212> DNA
<213> Artificial Sequence

<220> 
<223> IgG3 Hinge Humira

<400> 31
gctagcaagc ttgttatcca ccatggagac agacacactc ctgctatggg tactgctgct      60

ctgggttcca ggttccactg gtgacgagct caaaacccca cttggtgaca caactcacac     120

atgcccacgg tgcccagagc ccaaatcttg tgacacacct cccccgtgcc cacggtgccc     180

agagcccaaa tcttgtgaca cacctccccc atgcccacgg tgcccagagc ccaaatcttg     240

tgacacacct cccccgtgcc caaggtgccc agttaacggc ggcggcggca gcggtcccct     300

gggtgtgaga gcggcccagc cggccgacat ccagatgacc cagagcccca gcagcctgag     360

cgccagcgtg ggcgacagag tgaccatcac ctgcagagcc agccagggca tcagaaacta     420

cctggcctgg taccagcaga agcccggcaa ggcccccaag ctgctgatct acgccgccag     480

caccctgcag agcggcgtgc ccagcagatt cagcggcagc ggcagcggca ccgacttcac     540

cctgacctca gcagcctgca gcccgaggac gtggccacct actactgcca gagatacaac     600

agagccccct acaccttcgg ccagggcacc aaggtggaga tcaagagaac tgtggctgca     660

ccatctgtct tcatcttccc gccatctgat gagcagttga aatctggaac tgcctctgtt     720

gtgtgcctgc tgaataactt ctatcccaga gaggccaaag tacagtggaa ggtggataac     780

gccctccaat cgggtaactc ccaggagagt gtcacagagc aggacagcaa ggacagcacc     840

tacagcctca gcagcaccct gacgctgagc aaagcagact acgagaaaca caaactctac     900

gcctgcgaag tcacccatca gggcctgagc tcgcccgtca caaagagctt caacagggga     960

gagtgcctcg agcgagcaaa acgagcacca gtaaaacaaa cactaaactt cgacctacta    1020

aaactagcag gagacgtaga atcaaaccca ggaccagcca caaccatgga gacagacaca    1080

ctcctgctat gggtactgct gctctgggtt ccaggttcca ctggtgacga gctcaaaacc    1140

ccacttggtg acacaactca cacatgccca cggtgcccag agcccaaatc ttgtgacaca    1200

cctcccccgt gcccacggtg cccagagccc aaatcttgtg acacacctcc cccatgccca    1260

cggtgcccag agcccaaatc ttgtgacaca cctcccccgt gcccaaggtg cccaggcggc    1320

cgcggcggcg gcggcagcgg tcccctgggt gtgagaagat ctgaggtgca gctggtggag    1380

agcggcggcg gcctggtgca gcccggcaga agcctgagac tgagctgcgc cgccagcggc    1440

ttcaccttcg acgactacgc catgcactgg gtgagacagg cccccggcaa gggcctggag    1500

tgggtgagcg ccatcacctg gaacagcggc cacatcgact acgccgacag cgtggagggc    1560

agattcacca tcagcagaga caacgccaag aacagcctgt acctgcagat gaacagcctg    1620

agagccgagg acaccgccgt gtactactgc gccaaggtga gctacctgag caccgccagc    1680

agcctggact actggggcca gggcaccctg gtgaccgtga gcagcgcctc caccaaggga    1740

ccatcggtct tccccctggc accctcctcc aagagcacct ctgggggcac agcggccctg    1800

ggctgcctgg tcaaggacta cttccccgaa ccggtgacgg tgtcgtggaa ctcaggcgcc    1860

ctgaccagcg gcgtgcacac cttcccggct gtcctacagt cctcaggact ctactccctc    1920

agcagcgtgg tgaccgtgcc ctccagcagc ttgggcaccc agacctacat ctgcaacgtg    1980

aatcacaagc ccagcaacac caaggtcgac aagaaagttg agcccaaatc ttgtgacaaa    2040

actcacacat gcccaccgtg cccagcacct gaactcctgg ggggaccgtc agtcttcctc    2100

ttccccccaa aacccaagga caccctcatg atctcccgga cccctgaggt cacatgcgtg    2160

gtggtggacg tgagccacga agaccctgag gtcaagttca actggtacgt ggacggcgtg    2220

gaggtgcata atgccaagac aaagccgcgg gaggagcagt acaacagcac gtaccgggtg    2280

gtcagcgtcc tcaccgtcct gcaccaggac tggctgaatg gcaaggagta caagtgcaag    2340

gtctccaaca aagccctccc agcccccatc gagaaaacca tctccaaagc caaagggcag    2400

ccccgagaac cacaggtgta caccctgccc ccatcccggg atgagctgac caagaaccag    2460

gtcagcctga cctgcctggt caaaggcttc tatcccagcg acatcgccgt ggagtgggag    2520

agcaatgggc agccggagaa caactacaag accacgcctc ccgtgctgga ctccgacggc    2580

tccttcttcc tctacagcaa gctcaccgtg gacaagagca ggtggcagca ggggaacgtc    2640

ttctcatgct ccgtgatgca tgaggctctg cacaaccact acacgcagaa gagcctctcc    2700

ctgtctccgg gtaaataaat cgatggcgcg cc                                  2732


<210> 32
<211> 2433
<212> DNA
<213> Artificial Sequence

<220> 
<223> IgG4 Hinge Humira

<400> 32
gctagcaagc ttgttatcca ccatggagac agacacactc ctgctatggg tactgctgct      60

ctgggttcca ggttccactg gtgacgagtc caaatatggt cccccatgcc catcatgccc     120

agttaacggc ggcggcggca gcggtcccct gggtgtgaga gcggcccagc cggccgacat     180

ccagatgacc cagagcccca gcagcctgag cgccagcgtg ggcgacagag tgaccatcac     240

ctgcagagcc agccagggca tcagaaacta cctggcctgg taccagcaga agcccggcaa     300

ggcccccaag ctgctgatct acgccgccag caccctgcag agcggcgtgc ccagcagatt     360

cagcggcagc ggcagcggca ccgacttcac cctgaccatc agcagcctgc agcccgagga     420

cgtggccacc tactactgcc agagatacaa cagagccccc tacaccttcg gccagggcac     480

caaggtggag atcaagagaa ctgtggctgc accatctgtc ttcatcttcc cgccatctga     540

tgagcagttg aaatctggaa ctgcctctgt tgtgtgcctg ctgaataact tctatcccag     600

agaggccaaa gtacagtgga aggtggataa cgccctccaa tcgggtaact cccaggagag     660

tgtcacagag caggacagca aggacagcac ctacagcctc agcagcaccc tgacgctgag     720

caaagcagac tacgagaaac acaaactcta cgcctgcgaa gtcacccatc agggcctgag     780

ctcgcccgtc acaaagagct tcaacagggg agagtgcctc gagcgagcaa aacgagcacc     840

agtaaaacaa acactaaact tcgacctact aaaactagca ggagacgtag aatcaaaccc     900

aggaccagcc acaaccatgg agacagacac actcctgcta tgggtactgc tgctctgggt     960

tccaggttcc actggtgacg agtccaaata tggtccccca tgcccatcat gcccaggcgg    1020

ccgcggcggc ggcggcagcg gtcccctggg tgtgagaaga tctgaggtgc agctggtgga    1080

gagcggcggc ggcctggtgc agcccggcag aagcctgaga ctgagctgcg ccgccagcgg    1140

cttcaccttc gacgactacg ccatgcactg ggtgagacag gcccccggca agggcctgga    1200

gtgggtgagc gccatcacct ggaacagcgg ccacatcgac tacgccgaca gcgtggaggg    1260

cagattcacc atcagcagag acaacgccaa gaacagcctg tacctgcaga tgaacagcct    1320

gagagccgag gacaccgccg tgtactactg cgccaaggtg agctacctga gcaccgccag    1380

cagcctggac tactggggcc agggcaccct ggtgaccgtg agcagcgcct ccaccaaggg    1440

accatcggtc ttccccctgg caccctcctc caagagcacc tctgggggca cagcggccct    1500

gggctgcctg gtcaaggact acttccccga accggtgacg gtgtcgtgga actcaggcgc    1560

cctgaccagc ggcgtgcaca ccttcccggc tgtcctacag tcctcaggac tctactccct    1620

cagcagcgtg gtgaccgtgc cctccagcag cttgggcacc cagacctaca tctgcaacgt    1680

gaatcacaag cccagcaaca ccaaggtcga caagaaagtt gagcccaaat cttgtgacaa    1740

aactcacaca tgcccaccgt gcccagcacc tgaactcctg gggggaccgt cagtcttcct    1800

cttcccccca aaacccaagg acaccctcat gatctcccgg acccctgagg tcacatgcgt    1860

ggtggtggac gtgagccacg aagaccctga ggtcaagttc aactggtacg tggacggcgt    1920

ggaggtgcat aatgccaaga caaagccgcg ggaggagcag tacaacagca cgtaccgggt    1980

ggtcagcgtc ctcaccgtcc tgcaccagga ctggctgaat ggcaaggagt acaagtgcaa    2040

ggtctccaac aaagccctcc cagcccccat cgagaaaacc atctccaaag ccaaagggca    2100

gccccgagaa ccacaggtgt acaccctgcc cccatcccgg gatgagctga ccaagaacca    2160

ggtcagcctg acctgcctgg tcaaaggctt ctatcccagc gacatcgccg tggagtggga    2220

gagcaatggg cagccggaga acaactacaa gaccacgcct cccgtgctgg actccgacgg    2280

ctccttcttc ctctacagca agctcaccgt ggacaagagc aggtggcagc aggggaacgt    2340

cttctcatgc tccgtgatgc atgaggctct gcacaaccac tacacgcaga agagcctctc    2400

cctgtctccg ggtaaataaa tcgatggcgc gcc                                 2433


<210> 33
<211> 2475
<212> DNA
<213> Artificial Sequence

<220> 
<223> IgA1 Hinge Humira

<400> 33
gctagcaagc ttgttatcca ccatggagac agacacactc ctgctatggg tactgctgct      60

ctgggttcca ggttccactg gtgacccagt tccctcaact ccacctaccc catctccctc     120

aactccacct accccatctc cctcatgctg ccacgttaac ggcggcggcg gcagcggtcc     180

cctgggtgtg agagcggccc agccggccga catccagatg acccagagcc ccagcagcct     240

gagcgccagc gtgggcgaca gagtgaccat cacctgcaga gccagccagg gcatcagaaa     300

ctacctggcc tggtaccagc agaagcccgg caaggccccc aagctgctga tctacgccgc     360

cagcaccctg cagagcggcg tgcccagcag attcagcggc agcggcagcg gcaccgactt     420

caccctgacc atcagcagcc tgcagcccga ggacgtggcc acctactact gccagagata     480

caacagagcc ccctacacct tcggccaggg caccaaggtg gagatcaaga gaactgtggc     540

tgcaccatct gtcttcatct tcccgccatc tgatgagcag ttgaaatctg gaactgcctc     600

tgttgtgtgc ctgctgaata acttctatcc cagagaggcc aaagtacagt ggaaggtgga     660

taacgccctc caatcgggta actcccagga gagtgtcaca gagcaggaca gcaaggacag     720

cacctacagc ctcagcagca ccctgacgct gagcaaagca gactacgaga aacacaaact     780

ctacgcctgc gaagtcaccc atcagggcct gagctcgccc gtcacaaaga gcttcaacag     840

gggagagtgc ctcgagcgag caaaacgagc accagtaaaa caaacactaa acttcgacct     900

actaaaacta gcaggagacg tagaatcaaa cccaggacca gccacaacca tggagacaga     960

cacactcctg ctatgggtac tgctgctctg ggttccaggt tccactggtg acgagcccaa    1020

atcttgtgac aaaactcaca catgcccacc gtgcccaggc ggccgcggcg gcggcggcag    1080

cggtcccctg ggtgtgagaa gatctgaggt gcagctggtg gagagcggcg gcggcctggt    1140

gcagcccggc agaagcctga gactgagctg cgccgccagc ggcttcacct tcgacgacta    1200

cgccatgcac tgggtgagac aggcccccgg caagggcctg gagtgggtga gcgccatcac    1260

ctggaacagc ggccacatcg actacgccga cagcgtggag ggcagattca ccatcagcag    1320

agacaacgcc aagaacagcc tgtacctgca gatgaacagc ctgagagccg aggacaccgc    1380

cgtgtactac tgcgccaagg tgagctacct gagcaccgcc agcagcctgg actactgggg    1440

ccagggcacc ctggtgaccg tgagcagcgc ctccaccaag ggaccatcgg tcttccccct    1500

ggcaccctcc tccaagagca cctctggggg cacagcggcc ctgggctgcc tggtcaagga    1560

ctacttcccc gaaccggtga cggtgtcgtg gaactcaggc gccctgacca gcggcgtgca    1620

caccttcccg gctgtcctac agtcctcagg actctactcc ctcagcagcg tggtgaccgt    1680

gccctccagc agcttgggca cccagaccta catctgcaac gtgaatcaca agcccagcaa    1740

caccaaggtc gacaagaaag ttgagcccaa atcttgtgac aaaactcaca catgcccacc    1800

gtgcccagca cctgaactcc tggggggacc gtcagtcttc ctcttccccc caaaacccaa    1860

ggacaccctc atgatctccc ggacccctga ggtcacatgc gtggtggtgg acgtgagcca    1920

cgaagaccct gaggtcaagt tcaactggta cgtggacggc gtggaggtgc ataatgccaa    1980

gacaaagccg cgggaggagc agtacaacag cacgtaccgg gtggtcagcg tcctcaccgt    2040

cctgcaccag gactggctga atggcaagga gtacaagtgc aaggtctcca acaaagccct    2100

cccagccccc atcgagaaaa ccatctccaa agccaaaggg cagccccgag aaccacaggt    2160

gtacaccctg cccccatccc gggatgagct gaccaagaac caggtcagcc tgacctgcct    2220

ggtcaaaggc ttctatccca gcgacatcgc cgtggagtgg gagagcaatg ggcagccgga    2280

gaacaactac aagaccacgc ctcccgtgct ggactccgac ggctccttct tcctctacag    2340

caagctcacc gtggacaaga gcaggtggca gcaggggaac gtcttctcat gctccgtgat    2400

gcatgaggct ctgcacaacc actacacgca gaagagcctc tccctgtctc cgggtaaata    2460

aatcgatggc gcgcc                                                     2475


<210> 34
<211> 2420
<212> DNA
<213> Artificial Sequence

<220> 
<223> IgA2 Hinge Humira

<400> 34
gctagcaagc ttgttatcca ccatggagac agacacactc ctgctatggg tactgctgct      60

ctgggttcca ggttccactg gtgacccagt tcccccacct cccccatgct gccacgttaa     120

cggcggcggc ggcagcggtc ccctgggtgt gagagcggcc cagccggccg acatccagat     180

gacccagagc cccagcagcc tgagcgccag cgtgggcgac agagtgacca tcacctgcag     240

agccagccag ggcatcagaa actacctggc ctggtaccag cagaagcccg gcaaggcccc     300

caagctgctg atctacgccg ccagcaccct gcagagcggc gtgcccagca gattcagcgg     360

cagcggcagc ggcaccgact tcaccctgac catcagcagc ctgcagcccg aggacgtggc     420

cacctactac tgccagagat acaacagagc cccctacacc ttcggccagg gcaccaaggt     480

ggagatcaag agaactgtgg ctgcaccatc tgtcttcatc ttcccgccat ctgatgagca     540

gttgaaatct ggaactgcct ctgttgtgtg cctgctgaat aacttctatc ccagagaggc     600

caaagtacag tggaaggtgg ataacgccct ccaatcgggt aactcccagg agagtgtcac     660

agagcaggac agcaaggaca gcacctacag cctcagcagc accctgacgc tgagcaaagc     720

agactacgag aaacacaaac tctacgcctg cgaagtcacc catcagggcc tgagctcgcc     780

cgtcacaaag agcttcaaca ggggagagtg cctcgagcga gcaaaacgag caccagtaaa     840

acaaacacta aacttcgacc tactaaaact agcaggagac gtagaatcaa acccaggacc     900

agccacaacc atggagacag acacactcct gctatggtac tgctgctctg ggttccaggt     960

tccactggtg acccagttcc cccacctccc ccatgctgcc acggcggccg cggcggcggc    1020

ggcagcggtc ccctgggtgt gagaagatct gaggtgcagc tggtggagag cggcggcggc    1080

ctggtgcagc ccggcagaag cctgagactg agctgcgccg ccagcggctt caccttcgac    1140

gactacgcca tgcactgggt gagacaggcc cccggcaagg gcctggagtg ggtgagcgcc    1200

atcacctgga acagcggcca catcgactac gccgacagcg tggagggcag attcaccatc    1260

agcagagaca acgccaagaa cagcctgtac ctgcagatga acagcctgag agccgaggac    1320

accgccgtgt actactgcgc caaggtgagc tacctgagca ccgccagcag cctggactac    1380

tggggccagg gcaccctggt gaccgtgagc agcgcctcca ccaagggacc atcggtcttc    1440

cccctggcac cctcctccaa gagcacctct gggggcacag cggccctggg ctgcctggtc    1500

aaggactact tccccgaacc ggtgacggtg tcgtggaact caggcgccct gaccagcggc    1560

gtgcacacct tcccggctgt cctacagtcc tcaggactct actccctcag cagcgtggtg    1620

accgtgccct ccagcagctt gggcacccag acctacatct gcaacgtgaa tcacaagccc    1680

agcaacacca aggtcgacaa gaaagttgag cccaaatctt gtgacaaaac tcacacatgc    1740

ccaccgtgcc cagcacctga actcctgggg ggaccgtcag tcttcctctt ccccccaaaa    1800

cccaaggaca ccctcatgat ctcccggacc cctgaggtca catgcgtggt ggtggacgtg    1860

agccacgaag accctgaggt caagttcaac tggtacgtgg acggcgtgga ggtgcataat    1920

gccaagacaa agccgcggga ggagcagtac aacagcacgt accgggtggt cagcgtcctc    1980

accgtcctgc accaggactg gctgaatggc aaggagtaca agtgcaaggt ctccaacaaa    2040

gccctcccag cccccatcga gaaaaccatc tccaaagcca aagggcagcc ccgagaacca    2100

caggtgtaca ccctgccccc atcccgggat gagctgacca agaaccaggt cagcctgacc    2160

tgcctggtca aaggcttcta tcccagcgac atcgccgtgg agtgggagag caatgggcag    2220

ccggagaaca actacaagac cacgcctccc gtgctggact ccgacggctc cttcttcctc    2280

tacagcaagc tcaccgtgga caagagcagg tggcagcagg ggaacgtctt ctcatgctcc    2340

gtgatgcatg aggctctgca caaccactac acgcagaaga gcctctccct gtctccgggt    2400

aaataaatcg atggcgcgcc                                                2420


<210> 35
<211> 2465
<212> DNA
<213> Artificial Sequence

<220> 
<223> IgG1 Hinge Panitumumab

<400> 35
gctagcaagc ttgttatcca ccatggagac agacacactc ctgctatggg tactgctgct      60

ctgggttcca ggttccactg gtgacgagcc caaatcttgt gacaaaactc acacatgccc     120

accgtgccca gttaacggcg gcggcggcag cggtcccctg ggtgtgagag cggcccagcc     180

ggcgatattg tgatgaccca gagcccgctg agcctgccgg tgaccccagg cgaaccggcg     240

tcgattagct gccgcagctc gcagaacatc gtgcataata acggcattac ctatctggaa     300

tggtatctgc agaaaccggg ccaaagcccg cagctgttaa tttataaagt gagcgatcgc     360

tttagcggcg tgccggatcg cttttcgggc agcggtagtg gcaccgattt tacgctgaaa     420

attagccgcg tggaagcgga ggatgttggc gtgtattact gctttcaggg cagccatatc     480

ccgccaacct ttggccaagg caccaaagtg gaaattaaac gcgcgcggac tgtggctgca     540

ccatctgtct tcatcttccc gccatctgat gagcagttga aatctggaac tgcctctgtt     600

gtgtgcctgc tgaataactt ctatcccaga gaggccaaag tacagtggaa ggtggataac     660

gccctccaat cgggtaactc ccaggagagt gtcacagagc aggacagcaa ggacagcacc     720

tacagcctca gcagcaccct gacgctgagc aaagcagact acgagaaaca caaactctac     780

gcctgcgaag tcacccatca gggcctgagc tcgcccgtca caaagagctt caacagggga     840

gagtgcctcg agcgagcaaa acgagcacca gtaaaacaaa cactaaactt cgacctacta     900

aaactagcag gagacgtaga atcaaaccca ggaccagcca caaccatgga gacagacaca     960

ctcctgctat gggtactgct gctctgggtt ccaggttcca ctggtgacga gcccaaatct    1020

tgtgacaaaa ctcacacatg cccaccgtgc ccaggcggcc gcggcggcgg cggcagcggt    1080

cccctgggtg tgagaagatc tcaggtgcaa ctggttcaga gcggcgcgga agtgaaaaag    1140

ccgggcgcgt cggttaaagt gagctgcaaa gcctcaggct atacctttac gagctactgg    1200

atgcattggg tgcgccaggc cccgggtcag ggcctggaat ggatgggtaa catttatccg    1260

ggcagcggtg gcaccaacta tgcggaaaaa tttaagaacc gcgtgaccat gacgcgtgat    1320

accagcattt cgacggccta tatggaactg agccgcctgc gtagcgatga caccgccgtg    1380

tattactgcg cgcgcagtgg cggtccgtat tttttcgatt actggggcca gggtacgctg    1440

gttaccgtga gctcggcctc caccaaggga ccatcggtct tccccctggc accctcctcc    1500

aagagcacct ctgggggcac agcggccctg ggctgcctgg tcaaggacta cttccccgaa    1560

ccggtgacgg tgtcgtggaa ctcaggcgcc ctgaccagcg gcgtgcacac cttcccggct    1620

gtcctacagt cctcaggact ctactccctc agcagcgtgg tgaccgtgcc ctccagcagc    1680

ttgggcaccc agacctacat ctgcaacgtg aatcacaagc ccagcaacac caaggtggac    1740

aagagagttg tcgacgagcc caaatcttgt gacaaaactc acacatgccc accgtgccca    1800

gcacctgaac tcctgggggg accgtcagtc ttcctcttcc ccccaaaacc caaggacacc    1860

ctcatgatct cccggacccc tgaggtcaca tgcgtggtgg tggacgtgag ccacgaagac    1920

cctgaggtca agttcaactg gtacgtggac ggcgtggagg tgcataatgc caagacaaag    1980

ccgcgggagg agcagtacaa cagcacgtac cgtgtggtca gcgtcctcac cgtcctgcac    2040

caggactggc tgaatggcaa ggagtacaag tgcaaggtct ccaacaaagc cctcccagcc    2100

cccatcgaga aaaccatctc caaagccaaa gggcagcccc gagaaccaca ggtgtacacc    2160

ctgcccccat cccgggagga gatgaccaag aaccaggtca gcctgacctg cctggtcaaa    2220

ggcttctatc ccagcgacat cgccgtggag tgggagagca atgggcagcc ggagaacaac    2280

tacaagacca cgcctcccgt gctggactcc gacggctcct tcttcctcta tagcaagctc    2340

accgtggaca agagcaggtg gcagcagggg aacgtcttct catgctccgt gatgcatgag    2400

gctctgcaca accactacac gcagaagagc ctctccctgt ccccgggtaa aatcgatggc    2460

gcgcc                                                                2465


<210> 36
<211> 2439
<212> DNA
<213> Artificial Sequence

<220> 
<223> IgG1 Hinge Prolia

<400> 36
gctagcaagc ttgttatcca ccatggagac agacacactc ctgctatggg tactgctgct      60

ctgggttcca ggttccactg gtgacgagcc caaatcttgt gacaaaactc acacatgccc     120

accgtgccca gttaacggcg gcggcggcag cggtcccctg ggtgtgagag cggcccagcc     180

ggccgaaatt gtgttgacgc agtctccagg caccctgtct ttgtctccag gggaaagagc     240

caccctctcc tgtagggcca gtcagagtgt tcgcggcagg tacttagcct ggtaccagca     300

gaaacctggc caggctccca ggctcctcat ctatggtgca tccagcaggg ccactggcat     360

cccagacagg ttcagtggca gtgggtctgg gacagacttc actctcacca tcagcagact     420

ggagcctgaa gattttgcag tgttttactg tcagcagtat ggtagttcac ctcggacgtt     480

cggccaaggg accaaggtgg aaatcaaacg aactgtggct gcaccatctg tcttcatctt     540

cccgccatct gatgagcagt tgaaatctgg aactgcctct gttgtgtgcc tgctgaataa     600

cttctatccc agagaggcca aagtacagtg gaaggtggat aacgccctcc aatcgggtaa     660

ctcccaggag agtgtcacag agcaggacag caaggacagc acctacagcc tcagcagcac     720

cctgacgctg agcaaagcag actacgagaa acacaaactc tacgcctgcg aagtcaccca     780

tcagggcctg agctcgcccg tcacaaagag cttcaacagg ggagagtgcc tcgagcgagc     840

aaaacgagca ccagtaaaac aaacactaaa cttcgaccta ctaaaactag caggagacgt     900

agaatcaaac ccaggaccag ccacaaccat ggagacagac acactcctgc tatgggtact     960

gctgctctgg gttccaggtt ccactggtga cgagcccaaa tcttgtgaca aaactcacac    1020

atgcccaccg tgcccaggcg gccgcggcgg cggcggcagc ggtcccctgg gtgtgagaag    1080

atctgaagtg aagctggagg agtctggagg aggcttggtg caacctggag gatccatgaa    1140

actctcctgt gttgcctctg gattcatttt cagtaaccac tggatgaact gggtccgcca    1200

gtctccagag aaggggcttg agtgggttgc tgaaattaga tcaaaatcta ttaattctgc    1260

aacacattat gcggagtctg tgaaagggag gttcaccatc tcaagagatg attccaaaag    1320

tgctgtctac ctgcaaatga ccgacttaag aactgaagac actggcgttt attactgttc    1380

caggaattac tacggtagta cctacgacta ctggggccaa ggcaccactc tcacagtctc    1440

ctcagcctcc accaagggcc catcggtctt ccccctggca ccctcctcca agagcacctc    1500

tgggggcaca gcggccctgg gctgcctggt caaggactac ttccccgaac cggtgacggt    1560

gtcgtggaac tcaggcgccc tgaccagcgg cgtgcacacc ttcccggctg tcctacagtc    1620

ctcaggactc tactccctca gcagcgtggt gaccgtgccc tccagcagct tgggcaccca    1680

gacctacatc tgcaacgtga atcacaagcc cagcaacacc aaggtcgaca agacagttga    1740

gcgcaaatgt tgtgtcgagt gcccaccgtg cccagcacca cctgtggcag gaccgtcagt    1800

cttcctcttc cccccaaaac ccaaggacac cctcatgatc tcccggaccc ctgaggtcac    1860

gtgcgtggtg gtggacgtga gccacgaaga ccccgaggtc cagttcaact ggtacgtgga    1920

cggcgtggag gtgcataatg ccaagacaaa gccacgggag gagcagttca acagcacgtt    1980

ccgtgtggtc agcgtcctca ccgtcgtgca ccaggactgg ctgaacggca aggagtacaa    2040

gtgcaaggtc tccaacaaag gcctcccagc ccccatcgag aaaaccatct ccaaaaccaa    2100

agggcagccc cgagaaccac aggtgtacac cctgccccca tcccgggagg agatgaccaa    2160

gaaccaggtc agcctgacct gcctggtcaa aggcttctac cccagcgaca tcgccgtgga    2220

gtgggagagc aatgggcagc cggagaacaa ctacaagacc acacctccca tgctggactc    2280

cgacggctcc ttcttcctct acagcaagct caccgtggac aagagcaggt ggcagcaggg    2340

gaacgtcttc tcatgctccg tgatgcatga ggctctgcac aaccactaca cacagaagag    2400

cctctccctg tctccgggta aataaatcga tggcgcgcc                           2439


<210> 37
<211> 2421
<212> DNA
<213> Artificial Sequence

<220> 
<223> IgG2 Hinge Prolia

<400> 37
gctagcaagc ttgttatcca ccatggagac agacacactc ctgctatggg tactgctgct      60

ctgggttcca ggttccactg gtgacgagcg caaatgttgt gtcgagtgcc caccgtgccc     120

agttaacggc ggcggcggca gcggtcccct gggtgtgaga gcggcccagc cggccgaaat     180

tgtgttgacg cagtctccag gcaccctgtc tttgtctcca ggggaaagag ccaccctctc     240

ctgtagggcc agtcagagtg ttcgcggcag gtacttagcc tggtaccagc agaaacctgg     300

ccaggctccc aggctcctca tctatggtgc atccagcagg gccactggca tcccagacag     360

gttcagtggc agtgggtctg ggacagactt cactctcacc atcagcagac tggagcctga     420

agattttgca gtgttttact gtcagcagta tggtagttca cctcggacgt tcggccaagg     480

gaccaaggtg gaaatcaaac gaactgtggc tgcaccatct gtcttcatct tcccgccatc     540

tgatgagcag ttgaaatctg gaactgcctc tgttgtgtgc ctgctgaata acttctatcc     600

cagagaggcc aaagtacagt ggaaggtgga taacgccctc caatcgggta actcccagga     660

gagtgtcaca gagcaggaca gcaaggacag cacctacagc ctcagcagca ccctgacgct     720

gagcaaagca gactacgaga aacacaaact ctacgcctgc gaagtcaccc atcagggcct     780

gagctcgccc gtcacaaaga gcttcaacag gggagagtgc ctcgagcgag caaaacgagc     840

accagtaaaa caaacactaa acttcgacct actaaaacta gcaggagacg tagaatcaaa     900

cccaggacca gccacaacca tggagacaga cacactcctg ctatgggtac tgctgctctg     960

ggttccaggt tccactggtg acgagcgcaa atgttgtgtc gagtgcccac cgtgcccagg    1020

cggccgcggc ggcggcggca gcggtcccct gggtgtgaga agatctgaag tgaagctgga    1080

ggagtctgga ggaggcttgg tgcaacctgg aggatccatg aaactctcct gtgttgcctc    1140

tggattcatt ttcagtaacc actggatgaa ctgggtccgc cagtctccag agaaggggct    1200

tgagtgggtt gctgaaatta gatcaaaatc tattaattct gcaacacatt atgcggagtc    1260

tgtgaaaggg aggttcacca tctcaagaga tgattccaaa agtgctgtct acctgcaaat    1320

gaccgactta agaactgaag acactggcgt ttattactgt tccaggaatt actacggtag    1380

tacctacgac tactggggcc aaggcaccac tctcacagtc tcctcagcct ccaccaaggg    1440

cccatcggtc ttccccctgg caccctcctc caagagcacc tctgggggca cagcggccct    1500

gggctgcctg gtcaaggact acttccccga accggtgacg gtgtcgtgga actcaggcgc    1560

cctgaccagc ggcgtgcaca ccttcccggc tgtcctacag tcctcaggac tctactccct    1620

cagcagcgtg gtgaccgtgc cctccagcag cttgggcacc cagacctaca tctgcaacgt    1680

gaatcacaag cccagcaaca ccaaggtcga caagacagtt gagcgcaaat gttgtgtcga    1740

gtgcccaccg tgcccagcac cacctgtggc aggaccgtca gtcttcctct tccccccaaa    1800

acccaaggac accctcatga tctcccggac ccctgaggtc acgtgcgtgg tggtggacgt    1860

gagccacgaa gaccccgagg tccagttcaa ctggtacgtg gacggcgtgg aggtgcataa    1920

tgccaagaca aagccacggg aggagcagtt caacagcacg ttccgtgtgg tcagcgtcct    1980

caccgtcgtg caccaggact ggctgaacgg caaggagtac aagtgcaagg tctccaacaa    2040

aggcctccca gcccccatcg agaaaaccat ctccaaaacc aaagggcagc cccgagaacc    2100

acaggtgtac accctgcccc catcccggga ggagatgacc aagaaccagg tcagcctgac    2160

ctgcctggtc aaaggcttct accccagcga catcgccgtg gagtgggaga gcaatgggca    2220

gccggagaac aactacaaga ccacacctcc catgctggac tccgacggct ccttcttcct    2280

ctacagcaag ctcaccgtgg acaagagcag gtggcagcag gggaacgtct tctcatgctc    2340

cgtgatgcat gaggctctgc acaaccacta cacacagaag agcctctccc tgtctccggg    2400

taaataaatc gatggcgcgc c                                              2421


<210> 38
<211> 2759
<212> DNA
<213> Artificial Sequence

<220> 
<223> IgG3 Hinge Prolia

<400> 38
gctagcaagc ttgttatcca ccatggagac agacacactc ctgctatggg tactgctgct      60

ctgggttcca ggttccactg gtgacgagct caaaacccca cttggtgaca caactcacac     120

atgcccacgg tgcccagagc ccaaatcttg tgacacacct cccccgtgcc cacggtgccc     180

agagcccaaa tcttgtgaca cacctccccc atgcccacgg tgcccagagc ccaaatcttg     240

tgacacacct cccccgtgcc caaggtgccc agttaacggc ggcggcggca gcggtcccct     300

gggtgtgaga gcggcccagc cggccgaaat tgtgttgacg cagtctccag gcaccctgtc     360

tttgtctcca ggggaaagag ccaccctctc ctgtagggcc agtcagagtg ttcgcggcag     420

gtacttagcc tggtaccagc agaaacctgg ccaggctccc aggctcctca tctatggtgc     480

atccagcagg gccactggca tcccagacag gttcagtggc agtgggtctg ggacagactt     540

cactctcacc atcagcagac tggagcctga agattttgca gtgttttact gtcagcagta     600

tggtagttca cctcggacgt tcggccaagg gaccaaggtg gaaatcaaac gaactgtggc     660

tgcaccatct gtcttcatct tcccgccatc tgatgagcag ttgaaatctg gaactgcctc     720

tgttgtgtgc ctgctgaata acttctatcc cagagaggcc aaagtacagt ggaaggtgga     780

taacgccctc caatcgggta actcccagga gagtgtcaca gagcaggaca gcaaggacag     840

cacctacagc ctcagcagca ccctgacgct gagcaaagca gactacgaga aacacaaact     900

ctacgcctgc gaagtcaccc atcagggcct gagctcgccc gtcacaaaga gcttcaacag     960

gggagagtgc ctcgagcgag caaaacgagc accagtaaaa caaacactaa acttcgacct    1020

actaaaacta gcaggagacg tagaatcaaa cccaggacca gccacaacca tggagacaga    1080

cacactcctg ctatgggtac tgctgctctg ggttccaggt tccactggtg acgagctcaa    1140

aaccccactt ggtgacacaa ctcacacatg cccacggtgc ccagagccca aatcttgtga    1200

cacacctccc ccgtgcccac ggtgcccaga gcccaaatct tgtgacacac ctcccccatg    1260

cccacggtgc ccagagccca aatcttgtga cacacctccc ccgtgcccaa ggtgcccagg    1320

cggccgcggc ggcggcggca gcggtcccct gggtgtgaga agatctgaag tgaagctgga    1380

ggagtctgga ggaggcttgg tgcaacctgg aggatccatg aaactctcct gtgttgcctc    1440

tggattcatt ttcagtaacc actggatgaa ctgggtccgc cagtctccag agaaggggct    1500

tgagtgggtt gctgaaatta gatcaaaatc tattaattct gcaacacatt atgcggagtc    1560

tgtgaaaggg aggttcacca tctcaagaga tgattccaaa agtgctgtct acctgcaaat    1620

gaccgactta agaactgaag acactggcgt ttattactgt tccaggaatt actacggtag    1680

tacctacgac tactggggcc aaggcaccac tctcacagtc tcctcagcct ccaccaaggg    1740

cccatcggtc ttccccctgg caccctcctc caagagcacc tctgggggca cagcggccct    1800

gggctgcctg gtcaaggact acttccccga accggtgacg gtgtcgtgga actcaggcgc    1860

cctgaccagc ggcgtgcaca ccttcccggc tgtcctacag tcctcaggac tctactccct    1920

cagcagcgtg gtgaccgtgc cctccagcag cttgggcacc cagacctaca tctgcaacgt    1980

gaatcacaag cccagcaaca ccaaggtcga caagacagtt gagcgcaaat gttgtgtcga    2040

gtgcccaccg tgcccagcac cacctgtggc aggaccgtca gtcttcctct tccccccaaa    2100

acccaaggac accctcatga tctcccggac ccctgaggtc acgtgcgtgg tggtggacgt    2160

gagccacgaa gaccccgagg tccagttcaa ctggtacgtg gacggcgtgg aggtgcataa    2220

tgccaagaca aagccacggg aggagcagtt caacagcacg ttccgtgtgg tcagcgtcct    2280

caccgtcgtg caccaggact ggctgaacgg caaggagtac aagtgcaagg tctccaacaa    2340

aggcctccca gcccccatcg agaaaaccat ctccaaaacc aaagggcagc cccgagaacc    2400

acaggtgtac accctgcccc catcccggga ggagatgacc aagaaccagg tcagcctgac    2460

ctgcctggtc aaaggcttct accccagcga catcgccgtg gagtgggaga gcaatgggca    2520

gccggagaac aactacaaga ccacacctcc catgctggac tccgacggct ccttcttcct    2580

ctacagcaag ctcaccgtgg acaagagcag gtggcagcag gggaacgtct tctcatgctc    2640

cgtgatgcat gaggctctgc acaaccacta cacacagaag agcctctccc tgtctccggg    2700

taaataaaca cgcagaagag cctctccctg tctccgggta aataaatcga tggcgcgcc     2759


<210> 39
<211> 2421
<212> DNA
<213> Artificial Sequence

<220> 
<223> IgG4 Hinge Prolia

<400> 39
gctagcaagc ttgttatcca ccatggagac agacacactc ctgctatggg tactgctgct      60

ctgggttcca ggttccactg gtgacgagtc caaatatggt cccccatgcc catcatgccc     120

agttaacggc ggcggcggca gcggtcccct gggtgtgaga gcggcccagc cggccgaaat     180

tgtgttgacg cagtctccag gcaccctgtc tttgtctcca ggggaaagag ccaccctctc     240

ctgtagggcc agtcagagtg ttcgcggcag gtacttagcc tggtaccagc agaaacctgg     300

ccaggctccc aggctcctca tctatggtgc atccagcagg gccactggca tcccagacag     360

gttcagtggc agtgggtctg ggacagactt cactctcacc atcagcagac tggagcctga     420

agattttgca gtgttttact gtcagcagta tggtagttca cctcggacgt tcggccaagg     480

gaccaaggtg gaaatcaaac gaactgtggc tgcaccatct gtcttcatct tcccgccatc     540

tgatgagcag ttgaaatctg gaactgcctc tgttgtgtgc ctgctgaata acttctatcc     600

cagagaggcc aaagtacagt ggaaggtgga taacgccctc caatcgggta actcccagga     660

gagtgtcaca gagcaggaca gcaaggacag cacctacagc ctcagcagca ccctgacgct     720

gagcaaagca gactacgaga aacacaaact ctacgcctgc gaagtcaccc atcagggcct     780

gagctcgccc gtcacaaaga gcttcaacag gggagagtgc ctcgagcgag caaaacgagc     840

accagtaaaa caaacactaa acttcgacct actaaaacta gcaggagacg tagaatcaaa     900

cccaggacca gccacaacca tggagacaga cacactcctg ctatgggtac tgctgctctg     960

ggttccaggt tccactggtg acgagtccaa atatggtccc ccatgcccat catgcccagg    1020

cggccgcggc ggcggcggca gcggtcccct gggtgtgaga agatctgaag tgaagctgga    1080

ggagtctgga ggaggcttgg tgcaacctgg aggatccatg aaactctcct gtgttgcctc    1140

tggattcatt ttcagtaacc actggatgaa ctgggtccgc cagtctccag agaaggggct    1200

tgagtgggtt gctgaaatta gatcaaaatc tattaattct gcaacacatt atgcggagtc    1260

tgtgaaaggg aggttcacca tctcaagaga tgattccaaa agtgctgtct acctgcaaat    1320

gaccgactta agaactgaag acactggcgt ttattactgt tccaggaatt actacggtag    1380

tacctacgac tactggggcc aaggcaccac tctcacagtc tcctcagcct ccaccaaggg    1440

cccatcggtc ttccccctgg caccctcctc caagagcacc tctgggggca cagcggccct    1500

gggctgcctg gtcaaggact acttccccga accggtgacg gtgtcgtgga actcaggcgc    1560

cctgaccagc ggcgtgcaca ccttcccggc tgtcctacag tcctcaggac tctactccct    1620

cagcagcgtg gtgaccgtgc cctccagcag cttgggcacc cagacctaca tctgcaacgt    1680

gaatcacaag cccagcaaca ccaaggtcga caagacagtt gagcgcaaat gttgtgtcga    1740

gtgcccaccg tgcccagcac cacctgtggc aggaccgtca gtcttcctct tccccccaaa    1800

acccaaggac accctcatga tctcccggac ccctgaggtc acgtgcgtgg tggtggacgt    1860

gagccacgaa gaccccgagg tccagttcaa ctggtacgtg gacggcgtgg aggtgcataa    1920

tgccaagaca aagccacggg aggagcagtt caacagcacg ttccgtgtgg tcagcgtcct    1980

caccgtcgtg caccaggact ggctgaacgg caaggagtac aagtgcaagg tctccaacaa    2040

aggcctccca gcccccatcg agaaaaccat ctccaaaacc aaagggcagc cccgagaacc    2100

acaggtgtac accctgcccc catcccggga ggagatgacc aagaaccagg tcagcctgac    2160

ctgcctggtc aaaggcttct accccagcga catcgccgtg gagtgggaga gcaatgggca    2220

gccggagaac aactacaaga ccacacctcc catgctggac tccgacggct ccttcttcct    2280

ctacagcaag ctcaccgtgg acaagagcag gtggcagcag gggaacgtct tctcatgctc    2340

cgtgatgcat gaggctctgc acaaccacta cacacagaag agcctctccc tgtctccggg    2400

taaataaatc gatggcgcgc c                                              2421


<210> 40
<211> 2463
<212> DNA
<213> Artificial Sequence

<220> 
<223> IgA1 Hinge Prolia

<400> 40
gctagcaagc ttgttatcca ccatggagac agacacactc ctgctatggg tactgctgct      60

ctgggttcca ggttccactg gtgacccagt tccctcaact ccacctaccc catctccctc     120

aactccacct accccatctc cctcatgctg ccacgttaac ggcggcggcg gcagcggtcc     180

cctgggtgtg agagcggccc agccggccga aattgtgttg acgcagtctc caggcaccct     240

gtctttgtct ccaggggaaa gagccaccct ctcctgtagg gccagtcaga gtgttcgcgg     300

caggtactta gcctggtacc agcagaaacc tggccaggct cccaggctcc tcatctatgg     360

tgcatccagc agggccactg gcatcccaga caggttcagt ggcagtgggt ctgggacaga     420

cttcactctc accatcagca gactggagcc tgaagatttt gcagtgtttt actgtcagca     480

gtatggtagt tcacctcgga cgttcggcca agggaccaag gtggaaatca aacgaactgt     540

ggctgcacca tctgtcttca tcttcccgcc atctgatgag cagttgaaat ctggaactgc     600

ctctgttgtg tgcctgctga ataacttcta tcccagagag gccaaagtac agtggaaggt     660

ggataacgcc ctccaatcgg gtaactccca ggagagtgtc acagagcagg acagcaagga     720

cagcacctac agcctcagca gcaccctgac gctgagcaaa gcagactacg agaaacacaa     780

actctacgcc tgcgaagtca cccatcaggg cctgagctcg cccgtcacaa agagcttcaa     840

caggggagag tgcctcgagc gagcaaaacg agcaccagta aaacaaacac taaacttcga     900

cctactaaaa ctagcaggag acgtagaatc aaacccagga ccagccacaa ccatggagac     960

agacacactc ctgctatggg tactgctgct ctgggttcca ggttccactg gtgacgagcc    1020

caaatcttgt gacaaaactc acacatgccc accgtgccca ggcggccgcg gcggcggcgg    1080

cagcggtccc ctgggtgtga gaagatctga agtgaagctg gaggagtctg gaggaggctt    1140

ggtgcaacct ggaggatcca tgaaactctc ctgtgttgcc tctggattca ttttcagtaa    1200

ccactggatg aactgggtcc gccagtctcc agagaagggg cttgagtggg ttgctgaaat    1260

tagatcaaaa tctattaatt ctgcaacaca ttatgcggag tctgtgaaag ggaggttcac    1320

catctcaaga gatgattcca aaagtgctgt ctacctgcaa atgaccgact taagaactga    1380

agacactggc gtttattact gttccaggaa ttactacggt agtacctacg actactgggg    1440

ccaaggcacc actctcacag tctcctcagc ctccaccaag ggcccatcgg tcttccccct    1500

ggcaccctcc tccaagagca cctctggggg cacagcggcc ctgggctgcc tggtcaagga    1560

ctacttcccc gaaccggtga cggtgtcgtg gaactcaggc gccctgacca gcggcgtgca    1620

caccttcccg gctgtcctac agtcctcagg actctactcc ctcagcagcg tggtgaccgt    1680

gccctccagc agcttgggca cccagaccta catctgcaac gtgaatcaca agcccagcaa    1740

caccaaggtc gacaagacag ttgagcgcaa atgttgtgtc gagtgcccac cgtgcccagc    1800

accacctgtg gcaggaccgt cagtcttcct cttcccccca aaacccaagg acaccctcat    1860

gatctcccgg acccctgagg tcacgtgcgt ggtggtggac gtgagccacg aagaccccga    1920

ggtccagttc aactggtacg tggacggcgt ggaggtgcat aatgccaaga caaagccacg    1980

ggaggagcag ttcaacagca cgttccgtgt ggtcagcgtc ctcaccgtcg tgcaccagga    2040

ctggctgaac ggcaaggagt acaagtgcaa ggtctccaac aaaggcctcc cagcccccat    2100

cgagaaaacc atctccaaaa ccaaagggca gccccgagaa ccacaggtgt acaccctgcc    2160

cccatcccgg gaggagatga ccaagaacca ggtcagcctg acctgcctgg tcaaaggctt    2220

ctaccccagc gacatcgccg tggagtggga gagcaatggg cagccggaga acaactacaa    2280

gaccacacct cccatgctgg actccgacgg ctccttcttc ctctacagca agctcaccgt    2340

ggacaagagc aggtggcagc aggggaacgt cttctcatgc tccgtgatgc atgaggctct    2400

gcacaaccac tacacacaga agagcctctc cctgtctccg ggtaaataaa tcgatggcgc    2460

gcc                                                                  2463


<210> 41
<211> 2409
<212> DNA
<213> Artificial Sequence

<220> 
<223> IgA2 Hinge Prolia

<400> 41
gctagcaagc ttgttatcca ccatggagac agacacactc ctgctatggg tactgctgct      60

ctgggttcca ggttccactg gtgacccagt tcccccacct cccccatgct gccacgttaa     120

cggcggcggc ggcagcggtc ccctgggtgt gagagcggcc cagccggccg aaattgtgtt     180

gacgcagtct ccaggcaccc tgtctttgtc tccaggggaa agagccaccc tctcctgtag     240

ggccagtcag agtgttcgcg gcaggtactt agcctggtac cagcagaaac ctggccaggc     300

tcccaggctc ctcatctatg gtgcatccag cagggccact ggcatcccag acaggttcag     360

tggcagtggg tctgggacag acttcactct caccatcagc agactggagc ctgaagattt     420

tgcagtgttt tactgtcagc agtatggtag ttcacctcgg acgttcggcc aagggaccaa     480

ggtggaaatc aaacgaactg tggctgcacc atctgtcttc atcttcccgc catctgatga     540

gcagttgaaa tctggaactg cctctgttgt gtgcctgctg aataacttct atcccagaga     600

ggccaaagta cagtggaagg tggataacgc cctccaatcg ggtaactccc aggagagtgt     660

cacagagcag gacagcaagg acagcaccta cagcctcagc agcaccctga cgctgagcaa     720

agcagactac gagaaacaca aactctacgc ctgcgaagtc acccatcagg gcctgagctc     780

gcccgtcaca aagagcttca acaggggaga gtgcctcgag cgagcaaaac gagcaccagt     840

aaaacaaaca ctaaacttcg acctactaaa actagcagga gacgtagaat caaacccagg     900

accagccaca accatggaga cagacacact cctgctatgg gtactgctgc tctgggttcc     960

aggttccact ggtgacccag ttcccccacc tcccccatgc tgccacggcg gccgcggcgg    1020

cggcggcagc ggtcccctgg gtgtgagaag atctgaagtg aagctggagg agtctggagg    1080

aggcttggtg caacctggag gatccatgaa actctcctgt gttgcctctg gattcatttt    1140

cagtaaccac tggatgaact gggtccgcca gtctccagag aaggggcttg agtgggttgc    1200

tgaaattaga tcaaaatcta ttaattctgc aacacattat gcggagtctg tgaaagggag    1260

gttcaccatc tcaagagatg attccaaaag tgctgtctac ctgcaaatga ccgacttaag    1320

aactgaagac actggcgttt attactgttc caggaattac tacggtagta cctacgacta    1380

ctggggccaa ggcaccactc tcacagtctc ctcagcctcc accaagggcc catcggtctt    1440

ccccctggca ccctcctcca agagcacctc tgggggcaca gcggccctgg gctgcctggt    1500

caaggactac ttccccgaac cggtgacggt gtcgtggaac tcaggcgccc tgaccagcgg    1560

cgtgcacacc ttcccggctg tcctacagtc ctcaggactc tactccctca gcagcgtggt    1620

gaccgtgccc tccagcagct tgggcaccca gacctacatc tgcaacgtga atcacaagcc    1680

cagcaacacc aaggtcgaca agacagttga gcgcaaatgt tgtgtcgagt gcccaccgtg    1740

cccagcacca cctgtggcag gaccgtcagt cttcctcttc cccccaaaac ccaaggacac    1800

cctcatgatc tcccggaccc ctgaggtcac gtgcgtggtg gtggacgtga gccacgaaga    1860

ccccgaggtc cagttcaact ggtacgtgga cggcgtggag gtgcataatg ccaagacaaa    1920

gccacgggag gagcagttca acagcacgtt ccgtgtggtc agcgtcctca ccgtcgtgca    1980

ccaggactgg ctgaacggca aggagtacaa gtgcaaggtc tccaacaaag gcctcccagc    2040

ccccatcgag aaaaccatct ccaaaaccaa agggcagccc cgagaaccac aggtgtacac    2100

cctgccccca tcccgggagg agatgaccaa gaaccaggtc agcctgacct gcctggtcaa    2160

aggcttctac cccagcgaca tcgccgtgga gtgggagagc aatgggcagc cggagaacaa    2220

ctacaagacc acacctccca tgctggactc cgacggctcc ttcttcctct acagcaagct    2280

caccgtggac aagagcaggt ggcagcaggg gaacgtcttc tcatgctccg tgatgcatga    2340

ggctctgcac aaccactaca cacagaagag cctctccctg tctccgggta aataaatcga    2400

tggcgcgcc                                                            2409


<210> 42
<211> 2419
<212> DNA
<213> Artificial Sequence

<220> 
<223> IgG1 Hinge Raptiva

<400> 42
aagcttgtta tccaccatgg agacagacac actcctgcta tgggtactgc tgctctgggt      60

tccaggttcc actggtgacg agcccaaatc ttgtgacaaa actcacacat gcccaccgtg     120

cccagttaac ggcggcggcg gcagcccctt cagagcggcc cagccggccg acatccagat     180

gacccagagc cccagcagcc tgagcgccag cgtgggcgac agagtgacca tcacctgcag     240

agccagcaag accatcagca agtacctggc ctggtaccag cagaagcccg gcaaggcccc     300

caagctgctg atctacagcg gcagcaccct gcagagcggc gtgcccagca gattcagcgg     360

cagcggcagc ggcaccgact tcaccctgac catcagcagc ctgcagcccg aggacttcgc     420

cacctactac tgccagcagc acaacgagta ccccctgacc ttcggccagg gcaccaaggt     480

ggagatcaag agaactgtgg ctgcaccatc tgtcttcatc ttcccgccat ctgatgagca     540

gttgaaatct ggaactgcct ctgttgtgtg cctgctgaat aacttctatc ccagagaggc     600

caaagtacag tggaaggtgg ataacgccct ccaatcgggt aactcccagg agagtgtcac     660

agagcaggac agcaaggaca gcacctacag cctcagcagc accctgacgc tgagcaaagc     720

agactacgag aaacacaaac tctacgcctg cgaagtcacc catcagggcc tgagctcgcc     780

cgtcacaaag agcttcaaca ggggagagtg cctcgagcga gcaaaacgag caccagtaaa     840

acaaacacta aacttcgacc tactaaaact agcaggagac gtagaatcaa acccaggacc     900

agccacaacc atggagacag acacactcct gctatgggta ctgctgctct gggttccagg     960

ttccactggt gacgagccca aatcttgtga caaaactcac acatgcccac cgtgcccagg    1020

cggccgcggc ggcggcggca gccccttcag aagatctgag gtgcagctgg tggagagcgg    1080

cggcggcctg gtgcagcccg gcggcagcct gagactgagc tgcgccgcca gcggctacag    1140

cttcaccggc cactggatga actgggtgag acaggccccc ggcaagggcc tggagtgggt    1200

gggcatgatc caccccagcg acagcgagac cagatacaac cagaagttca aggacagatt    1260

caccatcagc gtggacaaga gcaagaacac cctgtacctg cagatgaaca gcctgagagc    1320

cgaggacacc gccgtgtact actgcgccag aggcatctac ttctacggca ccacctactt    1380

cgactactgg ggccagggca ccctggtgac cgtctcctca gcctccacca agggaccatc    1440

ggtcttcccc ctggcaccct cctccaagag cacctctggg ggcacagcgg ccctgggctg    1500

cctggtcaag gactacttcc ccgaaccggt gacggtgtcg tggaactcag gcgccctgac    1560

cagcggcgtg cacaccttcc cggctgtcct acagtcctca ggactctact ccctcagcag    1620

cgtggtgacc gtgccctcca gcagcttggg cacccagacc tacatctgca acgtgaatca    1680

caagcccagc aacaccaagg tcgacaagaa agttgagccc aaatcttgtg acaaaactca    1740

cacatgccca ccgtgcccag cacctgaact cctgggggga ccgtcagtct tcctcttccc    1800

cccaaaaccc aaggacaccc tcatgatctc ccggacccct gaggtcacat gcgtggtggt    1860

ggacgtgagc cacgaagacc ctgaggtcaa gttcaactgg tacgtggacg gcgtggaggt    1920

gcataatgcc aagacaaagc cgcgggagga gcagtacaac agcacgtacc gggtggtcag    1980

cgtcctcacc gtcctgcacc aggactggct gaatggcaag gagtacaagt gcaaggtctc    2040

caacaaagcc ctcccagccc ccatcgagaa aaccatctcc aaagccaaag ggcagccccg    2100

agaaccacag gtgtacaccc tgcccccatc ccgggatgag ctgaccaaga accaggtcag    2160

cctgacctgc ctggtcaaag gcttctatcc cagcgacatc gccgtggagt gggagagcaa    2220

tgggcagccg gagaacaact acaagaccac gcctcccgtg ctggactccg acggctcctt    2280

cttcctctac agcaagctca ccgtggacaa gagcaggtgg cagcagggga acgtcttctc    2340

atgctccgtg atgcatgagg ctctgcacaa ccactacacg cagaagagcc tctccctgtc    2400

tccgggtaaa taaatcgat                                                 2419


<210> 43
<211> 2448
<212> DNA
<213> Artificial Sequence

<220> 
<223> IgG1 Hinge Remicade

<400> 43
gctagcaagc ttgttatcca ccatggagac agacacactc ctgctatggg tactgctgct      60

ctgggttcca ggttccactg gtgacgagcc caaatcttgt gacaaaactc acacatgccc     120

accgtgccca gttaacggcg gcggcggcag cggtcccctg ggtgtgagag cggcccagcc     180

ggccgacatc ttgctgactc agtctccagc catcctgtct gtgagtccag gagaaagagt     240

cagtttctcc tgcagggcca gtcagttcgt tggctcaagc atccactggt atcagcaaag     300

aacaaatggt tctccaaggc ttctcataaa gtatgcttct gagtctatgt ctgggatccc     360

ttccaggttt agtggcagtg gatcagggac agattttact cttagcatca acactgtgga     420

gtctgaagat attgcagatt attactgtca acaaagtcat agctggccat tcacgttcgg     480

ctcggggaca aatttggaag taaaacggac tgtggctgca ccatctgtct tcatcttccc     540

gccatctgat gagcagttga aatctggaac tgcctctgtt gtgtgcctgc tgaataactt     600

ctatcccaga gaggccaaag tacagtggaa ggtggataac gccctccaat cgggtaactc     660

ccaggagagt gtcacagagc aggacagcaa ggacagcacc tacagcctca gcagcaccct     720

gacgctgagc aaagcagact acgagaaaca caaactctac gcctgcgaag tcacccatca     780

gggcctgagc tcgcccgtca caaagagctt caacagggga gagtgcctcg agcgagcaaa     840

acgagcacca gtaaaacaaa cactaaactt cgacctacta aaactagcag gagacgtaga     900

atcaaaccca ggaccagcca caaccatgga gacagacaca ctcctgctat gggtactgct     960

gctctgggtt ccaggttcca ctggtgacga gcccaaatct tgtgacaaaa ctcacacatg    1020

cccaccgtgc ccaggcggcc gcggcggcgg cggcagcggt cccctgggtg tgagaagatc    1080

tgaagtgaag ctggaggagt ctggaggagg cttggtgcaa cctggaggat ccatgaaact    1140

ctcctgtgtt gcctctggat tcattttcag taaccactgg atgaactggg tccgccagtc    1200

tccagagaag gggcttgagt gggttgctga aattagatca aaatctatta attctgcaac    1260

acattatgcg gagtctgtga aagggaggtt caccatctca agagatgatt ccaaaagtgc    1320

tgtctacctg caaatgaccg acttaagaac tgaagacact ggcgtttatt actgttccag    1380

gaattactac ggtagtacct acgactactg gggccaaggc accactctca cagtctcctc    1440

agcctccacc aagggcccat cggtcttccc cctggcaccc tcctccaaga gcacctctgg    1500

gggcacagcg gccctgggct gcctggtcaa ggactacttc cccgaaccgg tgacggtgtc    1560

gtggaactca ggcgccctga ccagcggcgt gcacaccttc ccggctgtcc tacagtcctc    1620

aggactctac tccctcagca gcgtggtgac cgtgccctcc agcagcttgg gcacccagac    1680

ctacatctgc aacgtgaatc acaagcccag caacaccaag gtcgacaaga aagttgagcc    1740

caaatcttgt gacaaaactc acacatgccc accgtgccca gcacctgaac tcctgggggg    1800

accgtcagtc ttcctcttcc ccccaaaacc caaggacacc ctcatgatct cccggacccc    1860

tgaggtcaca tgcgtggtgg tggacgtgag ccacgaagac cctgaggtca agttcaactg    1920

gtacgtggac ggcgtggagg tgcataatgc caagacaaag ccgcgggagg agcagtacaa    1980

cagcacgtac cgggtggtca gcgtcctcac cgtcctgcac caggactggc tgaatggcaa    2040

ggagtacaag tgcaaggtct ccaacaaagc cctcccagcc cccatcgaga aaaccatctc    2100

caaagccaaa gggcagcccc gagaaccaca ggtgtacacc ctgcccccat cccgggatga    2160

gctgaccaag aaccaggtca gcctgacctg cctggtcaaa ggcttctatc ccagcgacat    2220

cgccgtggag tgggagagca atgggcagcc ggagaacaac tacaagacca cgcctcccgt    2280

gctggactcc gacggctcct tcttcctcta cagcaagctc accgtggaca agagcaggtg    2340

gcagcagggg aacgtcttct catgctccgt gatgcatgag gctctgcaca accactacac    2400

gcagaagagc ctctccctgt ctccgggtaa ataaatcgat ggcgcgcc                 2448


<210> 44
<211> 2430
<212> DNA
<213> Artificial Sequence

<220> 
<223> IgG2 Hinge Remicade

<400> 44
gctagcaagc ttgttatcca ccatggagac agacacactc ctgctatggg tactgctgct      60

ctgggttcca ggttccactg gtgacgagcg caaatgttgt gtcgagtgcc caccgtgccc     120

agttaacggc ggcggcggca gcggtcccct gggtgtgaga gcggcccagc cggccgacat     180

cttgctgact cagtctccag ccatcctgtc tgtgagtcca ggagaaagag tcagtttctc     240

ctgcagggcc agtcagttcg ttggctcaag catccactgg tatcagcaaa gaacaaatgg     300

ttctccaagg cttctcataa agtatgcttc tgagtctatg tctgggatcc cttccaggtt     360

tagtggcagt ggatcaggga cagattttac tcttagcatc aacactgtgg agtctgaaga     420

tattgcagat tattactgtc aacaaagtca tagctggcca ttcacgttcg gctcggggac     480

aaatttggaa gtaaaacgga ctgtggctgc accatctgtc ttcatcttcc cgccatctga     540

tgagcagttg aaatctggaa ctgcctctgt tgtgtgcctg ctgaataact tctatcccag     600

agaggccaaa gtacagtgga aggtggataa cgccctccaa tcgggtaact cccaggagag     660

tgtcacagag caggacagca aggacagcac ctacagcctc agcagcaccc tgacgctgag     720

caaagcagac tacgagaaac acaaactcta cgcctgcgaa gtcacccatc agggcctgag     780

ctcgcccgtc acaaagagct tcaacagggg agagtgcctc gagcgagcaa aacgagcacc     840

agtaaaacaa acactaaact tcgacctact aaaactagca ggagacgtag aatcaaaccc     900

aggaccagcc acaaccatgg agacagacac actcctgcta tgggtactgc tgctctgggt     960

tccaggttcc actggtgacg agcgcaaatg ttgtgtcgag tgcccaccgt gcccaggcgg    1020

ccgcggcggc ggcggcagcg gtcccctggg tgtgagaaga tctgaagtga agctggagga    1080

gtctggagga ggcttggtgc aacctggagg atccatgaaa ctctcctgtg ttgcctctgg    1140

attcattttc agtaaccact ggatgaactg ggtccgccag tctccagaga aggggcttga    1200

gtgggttgct gaaattagat caaaatctat taattctgca acacattatg cggagtctgt    1260

gaaagggagg ttcaccatct caagagatga ttccaaaagt gctgtctacc tgcaaatgac    1320

cgacttaaga actgaagaca ctggcgttta ttactgttcc aggaattact acggtagtac    1380

ctacgactac tggggccaag gcaccactct cacagtctcc tcagcctcca ccaagggccc    1440

atcggtcttc cccctggcac cctcctccaa gagcacctct gggggcacag cggccctggg    1500

ctgcctggtc aaggactact tccccgaacc ggtgacggtg tcgtggaact caggcgccct    1560

gaccagcggc gtgcacacct tcccggctgt cctacagtcc tcaggactct actccctcag    1620

cagcgtggtg accgtgccct ccagcagctt gggcacccag acctacatct gcaacgtgaa    1680

tcacaagccc agcaacacca aggtcgacaa gaaagttgag cccaaatctt gtgacaaaac    1740

tcacacatgc ccaccgtgcc cagcacctga actcctgggg ggaccgtcag tcttcctctt    1800

ccccccaaaa cccaaggaca ccctcatgat ctcccggacc cctgaggtca catgcgtggt    1860

ggtggacgtg agccacgaag accctgaggt caagttcaac tggtacgtgg acggcgtgga    1920

ggtgcataat gccaagacaa agccgcggga ggagcagtac aacagcacgt accgggtggt    1980

cagcgtcctc accgtcctgc accaggactg gctgaatggc aaggagtaca agtgcaaggt    2040

ctccaacaaa gccctcccag cccccatcga gaaaaccatc tccaaagcca aagggcagcc    2100

ccgagaacca caggtgtaca ccctgccccc atcccgggat gagctgacca agaaccaggt    2160

cagcctgacc tgcctggtca aaggcttcta tcccagcgac atcgccgtgg agtgggagag    2220

caatgggcag ccggagaaca actacaagac cacgcctccc gtgctggact ccgacggctc    2280

cttcttcctc tacagcaagc tcaccgtgga caagagcagg tggcagcagg ggaacgtctt    2340

ctcatgctcc gtgatgcatg aggctctgca caaccactac acgcagaaga gcctctccct    2400

gtctccgggt aaataaatcg atggcgcgcc                                     2430


<210> 45
<211> 3048
<212> DNA
<213> Artificial Sequence

<220> 
<223> IgG3 Hinge Remicade

<400> 45
gctagcaagc ttgttatcca ccatggagac agacacactc ctgctatggg tactgctgct      60

ctgggttcca ggttccactg gtgacgagct caaaacccca cttggtgaca caactcacac     120

atgcccacgg tgcccagagc ccaaatcttg tgacacacct cccccgtgcc cacggtgccc     180

agagcccaaa tcttgtgaca cacctccccc atgcccacgg tgcccagagc ccaaatcttg     240

tgacacacct cccccgtgcc caaggtgccc agttaacggc ggcggcggca gcggtcccct     300

gggtgtgaga gcggcccagc cggccgacat cttgctgact cagtctccag ccatcctgtc     360

tgtgagtcca ggagaaagag tcagtttctc ctgcagggcc agtcagttcg ttggctcaag     420

catccactgg tatcagcaaa gaacaaatgg ttctccaagg cttctcataa agtatgcttc     480

tgagtctatg tctgggatcc cttccaggtt tagtggcagt ggatcaggga cagattttac     540

tcttagcatc aacactgtgg agtctgaaga tattgcagat tattactgtc aacaaagtca     600

tagctggcca ttcacgttcg gctcggggac aaatttggaa gtaaaacgga ctgtggctgc     660

accatctgtc ttcatcttcc cgccatctga tgagcagttg aaatctggaa ctgcctctgt     720

tgtgtgcctg ctgaataact tctatcccag agaggccaaa gtacagtgga aggtggataa     780

cgccctccaa tcgggtaact cccaggagag tgtcacagag caggacagca aggacagcac     840

ctacagcctc agcagcaccc tgacgctgag caaagcagac tacgagaaac acaaactcta     900

cgcctgcgaa gtcacccatc agggcctgag ctcgcccgtc acaaagagct tcaacagggg     960

agagtgcctc gagcgagcaa aacgagcacc agtaaaacaa acactaaact tcgacctact    1020

aaaactagca ggagacgtag aatcaaaccc aggaccagcc acaaccatgg agacagacac    1080

actcctgcta tgggtactgc tgctctgggt tccaggttcc actggtgacg agctcaaaac    1140

cccacttggt gacacaactc acacatgccc acggtgccca gagcccaaat cttgtgacac    1200

acctcccccg tgcccacggt gcccagagcc caaatcttgt gacacacctc ccccatgccc    1260

acggtgccca gagcccaaat cttgtgacac acctcccccg tgcccaaggt gcccaggcgg    1320

ccgcggcggc ggcggcagcg gtcccctggg tgtgagaaga tctgaagtga agctggagga    1380

gtctggagga ggcttggtgc aacctggagg atccatgaaa ctctcctgtg ttgcctctgg    1440

attcattttc agtaaccact ggatgaactg ggtccgccag tctccagaga aggggcttga    1500

gtgggttgct gaaattagat caaaatctat taattctgca acacattatg cggagtctgt    1560

gaaagggagg ttcaccatct caagagatga ttccaaaagt gctgtctacc tgcaaatgac    1620

cgacttaaga actgaagaca ctggcgttta ttactgttcc aggaattact acggtagtac    1680

ctacgactac tggggccaag gcaccactct cacagtctcc tcagcctcca ccaagggccc    1740

atcggtcttc cccctggcac cctcctccaa gagcacctct gggggcacag cggccctggg    1800

ctgcctggtc aaggactact tccccgaacc ggtgacggtg tcgtggaact caggcgccct    1860

gaccagcggc gtgcacacct tcccggctgt cctacagtcc tcaggactct actccctcag    1920

cagcgtggtg accgtgccct ccagcagctt gggcacccag acctacatct gcaacgtgaa    1980

tcacaagccc agcaacacca aggtcgacaa gaaagttgag cccaaatctt gtgacaaaac    2040

tcacacatgc ccaccgtgcc cagcacctga actcctgggg ggaccgtcag tcttcctctt    2100

ccccccaaaa cccaaggaca ccctcatgat ctcccggacc cctgaggtca catgcgtggt    2160

ggtggacgtg agccacgaag accctgaggt caagttcaac tggtacgtgg acggcgtgga    2220

ggtgcataat gccaagacaa agccgcggga ggagcagtac aacagcacgt accgggtggt    2280

cagcgtcctc accgtcctgc accaggactg gctgaatggc aaggagtaca agtgcaaggt    2340

ctccaacaaa gccctcccag cccccatcga gaaaaccatc tccaaagcca aagggcagcc    2400

ccgagaacca caggtgtaca ccctgccccc atcccgggat gagctgacca agaaccaggt    2460

cagcctgacc tgcctggtca aaggcttcta tcccagcgac atcgccgtgg agtgggagag    2520

caatgggcag ccggagaaca actacaagac cacgcctccc gtgctggact ccgacggctc    2580

cttcttcctc tacagcaagc tcaccgtgga caagagcagg tggcagcagg ggaacgtctt    2640

ctcatgctcc gtgatgcatg aggctctgca caaccactcc cccatcgaga aaaccatctc    2700

caaagccaaa gggcagcccc gagaaccaca ggtgtacacc ctgcccccat cccgggatga    2760

gctgaccaag aaccaggtca gcctgacctg cctggtcaaa ggcttctatc ccagcgacat    2820

cgccgtggag tgggagagca atgggcagcc ggagaacaac tacaagacca cgcctcccgt    2880

gctggactcc gacggctcct tcttcctcta cagcaagctc accgtggaca agagcaggtg    2940

gcagcagggg aacgtcttct catgctccgt gatgcatgag gctctgcaca accactacac    3000

gcagaagagc ctctccctgt ctccgggtaa ataaatcgat ggcgcgcc                 3048


<210> 46
<211> 2430
<212> DNA
<213> Artificial Sequence

<220> 
<223> IgG4 Hinge Remicade

<400> 46
gctagcaagc ttgttatcca ccatggagac agacacactc ctgctatggg tactgctgct      60

ctgggttcca ggttccactg gtgacgagtc caaatatggt cccccatgcc catcatgccc     120

agttaacggc ggcggcggca gcggtcccct gggtgtgaga gcggcccagc cggccgacat     180

cttgctgact cagtctccag ccatcctgtc tgtgagtcca ggagaaagag tcagtttctc     240

ctgcagggcc agtcagttcg ttggctcaag catccactgg tatcagcaaa gaacaaatgg     300

ttctccaagg cttctcataa agtatgcttc tgagtctatg tctgggatcc cttccaggtt     360

tagtggcagt ggatcaggga cagattttac tcttagcatc aacactgtgg agtctgaaga     420

tattgcagat tattactgtc aacaaagtca tagctggcca ttcacgttcg gctcggggac     480

aaatttggaa gtaaaacgga ctgtggctgc accatctgtc ttcatcttcc cgccatctga     540

tgagcagttg aaatctggaa ctgcctctgt tgtgtgcctg ctgaataact tctatcccag     600

agaggccaaa gtacagtgga aggtggataa cgccctccaa tcgggtaact cccaggagag     660

tgtcacagag caggacagca aggacagcac ctacagcctc agcagcaccc tgacgctgag     720

caaagcagac tacgagaaac acaaactcta cgcctgcgaa gtcacccatc agggcctgag     780

ctcgcccgtc acaaagagct tcaacagggg agagtgcctc gagcgagcaa aacgagcacc     840

agtaaaacaa acactaaact tcgacctact aaaactagca ggagacgtag aatcaaaccc     900

aggaccagcc acaaccatgg agacagacac actcctgcta tgggtactgc tgctctgggt     960

tccaggttcc actggtgacg agtccaaata tggtccccca tgcccatcat gcccaggcgg    1020

ccgcggcggc ggcggcagcg gtcccctggg tgtgagaaga tctgaagtga agctggagga    1080

gtctggagga ggcttggtgc aacctggagg atccatgaaa ctctcctgtg ttgcctctgg    1140

attcattttc agtaaccact ggatgaactg ggtccgccag tctccagaga aggggcttga    1200

gtgggttgct gaaattagat caaaatctat taattctgca acacattatg cggagtctgt    1260

gaaagggagg ttcaccatct caagagatga ttccaaaagt gctgtctacc tgcaaatgac    1320

cgacttaaga actgaagaca ctggcgttta ttactgttcc aggaattact acggtagtac    1380

ctacgactac tggggccaag gcaccactct cacagtctcc tcagcctcca ccaagggccc    1440

atcggtcttc cccctggcac cctcctccaa gagcacctct gggggcacag cggccctggg    1500

ctgcctggtc aaggactact tccccgaacc ggtgacggtg tcgtggaact caggcgccct    1560

gaccagcggc gtgcacacct tcccggctgt cctacagtcc tcaggactct actccctcag    1620

cagcgtggtg accgtgccct ccagcagctt gggcacccag acctacatct gcaacgtgaa    1680

tcacaagccc agcaacacca aggtcgacaa gaaagttgag cccaaatctt gtgacaaaac    1740

tcacacatgc ccaccgtgcc cagcacctga actcctgggg ggaccgtcag tcttcctctt    1800

ccccccaaaa cccaaggaca ccctcatgat ctcccggacc cctgaggtca catgcgtggt    1860

ggtggacgtg agccacgaag accctgaggt caagttcaac tggtacgtgg acggcgtgga    1920

ggtgcataat gccaagacaa agccgcggga ggagcagtac aacagcacgt accgggtggt    1980

cagcgtcctc accgtcctgc accaggactg gctgaatggc aaggagtaca agtgcaaggt    2040

ctccaacaaa gccctcccag cccccatcga gaaaaccatc tccaaagcca aagggcagcc    2100

ccgagaacca caggtgtaca ccctgccccc atcccgggat gagctgacca agaaccaggt    2160

cagcctgacc tgcctggtca aaggcttcta tcccagcgac atcgccgtgg agtgggagag    2220

caatgggcag ccggagaaca actacaagac cacgcctccc gtgctggact ccgacggctc    2280

cttcttcctc tacagcaagc tcaccgtgga caagagcagg tggcagcagg ggaacgtctt    2340

ctcatgctcc gtgatgcatg aggctctgca caaccactac acgcagaaga gcctctccct    2400

gtctccgggt aaataaatcg atggcgcgcc                                     2430


<210> 47
<211> 2421
<212> DNA
<213> Artificial Sequence

<220> 
<223> IgA1 Hinge Remicade

<400> 47
gctagcaagc ttgttatcca ccatggagac agacacactc ctgctatggg tactgctgct      60

ctgggttcca ggttccactg gtgacccagt tccctcaact ccacctaccc catctccctc     120

aactccacct accccatctc cctcatgctg ccacgttaac ggcggcggcg gcagcggtcc     180

cctgggtgtg agagcggccc agccggccag agtcagtttc tcctgcaggg ccagtcagtt     240

cgttggctca agcatccact ggtatcagca aagaacaaat ggttctccaa ggcttctcat     300

aaagtatgct tctgagtcta tgtctgggat cccttccagg tttagtggca gtggatcagg     360

gacagatttt actcttagca tcaacactgt ggagtctgaa gatattgcag attattactg     420

tcaacaaagt catagctggc cattcacgtt cggctcgggg acaaatttgg aagtaaaacg     480

gactgtggct gcaccatctg tcttcatctt cccgccatct gatgagcagt tgaaatctgg     540

aactgcctct gttgtgtgcc tgctgaataa cttctatccc agagaggcca aagtacagtg     600

gaaggtggat aacgccctcc aatcgggtaa ctcccaggag agtgtcacag agcaggacag     660

caaggacagc acctacagcc tcagcagcac cctgacgctg agcaaagcag actacgagaa     720

acacaaactc tacgcctgcg aagtcaccca tcagggcctg agctcgcccg tcacaaagag     780

cttcaacagg ggagagtgcc tcgagcgagc aaaacgagca ccagtaaaac aaacactaaa     840

cttcgaccta ctaaaactag caggagacgt agaatcaaac ccaggaccag ccacaaccat     900

ggagacagac acactcctgc tatgggtact gctgctctgg gttccaggtt ccactggtga     960

cgagcccaaa tcttgtgaca aaactcacac atgcccaccg tgcccaggcg gccgcggcgg    1020

cggcggcagc ggtcccctgg gtgtgagaag atctgaagtg aagctggagg agtctggagg    1080

aggcttggtg caacctggag gatccatgaa actctcctgt gttgcctctg gattcatttt    1140

cagtaaccac tggatgaact gggtccgcca gtctccagag aaggggcttg agtgggttgc    1200

tgaaattaga tcaaaatcta ttaattctgc aacacattat gcggagtctg tgaaagggag    1260

gttcaccatc tcaagagatg attccaaaag tgctgtctac ctgcaaatga ccgacttaag    1320

aactgaagac actggcgttt attactgttc caggaattac tacggtagta cctacgacta    1380

ctggggccaa ggcaccactc tcacagtctc ctcagcctcc accaagggcc catcggtctt    1440

ccccctggca ccctcctcca agagcacctc tgggggcaca gcggccctgg gctgcctggt    1500

caaggactac ttccccgaac cggtgacggt gtcgtggaac tcaggcgccc tgaccagcgg    1560

cgtgcacacc ttcccggctg tcctacagtc ctcaggactc tactccctca gcagcgtggt    1620

gaccgtgccc tccagcagct tgggcaccca gacctacatc tgcaacgtga atcacaagcc    1680

cagcaacacc aaggtcgaca agaaagttga gcccaaatct tgtgacaaaa ctcacacatg    1740

cccaccgtgc ccagcacctg aactcctggg gggaccgtca gtcttcctct tccccccaaa    1800

acccaaggac accctcatga tctcccggac ccctgaggtc acatgcgtgg tggtggacgt    1860

gagccacgaa gaccctgagg tcaagttcaa ctggtacgtg gacggcgtgg aggtgcataa    1920

tgccaagaca aagccgcggg aggagcagta caacagcacg taccgggtgg tcagcgtcct    1980

caccgtcctg caccaggact ggctgaatgg caaggagtac aagtgcaagg tctccaacaa    2040

agccctccca gcccccatcg agaaaaccat ctccaaagcc aaagggcagc cccgagaacc    2100

acaggtgtac accctgcccc catcccggga tgagctgacc aagaaccagg tcagcctgac    2160

ctgcctggtc aaaggcttct atcccagcga catcgccgtg gagtgggaga gcaatgggca    2220

gccggagaac aactacaaga ccacgcctcc cgtgctggac tccgacggct ccttcttcct    2280

ctacagcaag ctcaccgtgg acaagagcag gtggcagcag gggaacgtct tctcatgctc    2340

cgtgatgcat gaggctctgc acaaccacta cacgcagaag agcctctccc tgtctccggg    2400

taaataaatc gatggcgcgc c                                              2421


<210> 48
<211> 2418
<212> DNA
<213> Artificial Sequence

<220> 
<223> IgA2 Hinge Remicade

<400> 48
gctagcaagc ttgttatcca ccatggagac agacacactc ctgctatggg tactgctgct      60

ctgggttcca ggttccactg gtgacccagt tcccccacct cccccatgct gccacgttaa     120

cggcggcggc ggcagcggtc ccctgggtgt gagagcggcc cagccggccg acatcttgct     180

gactcagtct ccagccatcc tgtctgtgag tccaggagaa agagtcagtt tctcctgcag     240

ggccagtcag ttcgttggct caagcatcca ctggtatcag caaagaacaa atggttctcc     300

aaggcttctc ataaagtatg cttctgagtc tatgtctggg atcccttcca ggtttagtgg     360

cagtggatca gggacagatt ttactcttag catcaacact gtggagtctg aagatattgc     420

agattattac tgtcaacaaa gtcatagctg gccattcacg ttcggctcgg ggacaaattt     480

ggaagtaaaa cggactgtgg ctgcaccatc tgtcttcatc ttcccgccat ctgatgagca     540

gttgaaatct ggaactgcct ctgttgtgtg cctgctgaat aacttctatc ccagagaggc     600

caaagtacag tggaaggtgg ataacgccct ccaatcgggt aactcccagg agagtgtcac     660

agagcaggac agcaaggaca gcacctacag cctcagcagc accctgacgc tgagcaaagc     720

agactacgag aaacacaaac tctacgcctg cgaagtcacc catcagggcc tgagctcgcc     780

cgtcacaaag agcttcaaca ggggagagtg cctcgagcga gcaaaacgag caccagtaaa     840

acaaacacta aacttcgacc tactaaaact agcaggagac gtagaatcaa acccaggacc     900

agccacaacc atggagacag acacactcct gctatgggta ctgctgctct gggttccagg     960

ttccactggt gacccagttc ccccacctcc cccatgctgc cacggcggcc gcggcggcgg    1020

cggcagcggt cccctgggtg tgagaagatc tgaagtgaag ctggaggagt ctggaggagg    1080

cttggtgcaa cctggaggat ccatgaaact ctcctgtgtt gcctctggat tcattttcag    1140

taaccactgg atgaactggg tccgccagtc tccagagaag gggcttgagt gggttgctga    1200

aattagatca aaatctatta attctgcaac acattatgcg gagtctgtga aagggaggtt    1260

caccatctca agagatgatt ccaaaagtgc tgtctacctg caaatgaccg acttaagaac    1320

tgaagacact ggcgtttatt actgttccag gaattactac ggtagtacct acgactactg    1380

gggccaaggc accactctca cagtctcctc agcctccacc aagggcccat cggtcttccc    1440

cctggcaccc tcctccaaga gcacctctgg gggcacagcg gccctgggct gcctggtcaa    1500

ggactacttc cccgaaccgg tgacggtgtc gtggaactca ggcgccctga ccagcggcgt    1560

gcacaccttc ccggctgtcc tacagtcctc aggactctac tccctcagca gcgtggtgac    1620

cgtgccctcc agcagcttgg gcacccagac ctacatctgc aacgtgaatc acaagcccag    1680

caacaccaag gtcgacaaga aagttgagcc caaatcttgt gacaaaactc acacatgccc    1740

accgtgccca gcacctgaac tcctgggggg accgtcagtc ttcctcttcc ccccaaaacc    1800

caaggacacc ctcatgatct cccggacccc tgaggtcaca tgcgtggtgg tggacgtgag    1860

ccacgaagac cctgaggtca agttcaactg gtacgtggac ggcgtggagg tgcataatgc    1920

caagacaaag ccgcgggagg agcagtacaa cagcacgtac cgggtggtca gcgtcctcac    1980

cgtcctgcac caggactggc tgaatggcaa ggagtacaag tgcaaggtct ccaacaaagc    2040

cctcccagcc cccatcgaga aaaccatctc caaagccaaa gggcagcccc gagaaccaca    2100

ggtgtacacc ctgcccccat cccgggatga gctgaccaag aaccaggtca gcctgacctg    2160

cctggtcaaa ggcttctatc ccagcgacat cgccgtggag tgggagagca atgggcagcc    2220

ggagaacaac tacaagacca cgcctcccgt gctggactcc gacggctcct tcttcctcta    2280

cagcaagctc accgtggaca agagcaggtg gcagcagggg aacgtcttct catgctccgt    2340

gatgcatgag gctctgcaca accactacac gcagaagagc ctctccctgt ctccgggtaa    2400

ataaatcgat ggcgcgcc                                                  2418


<210> 49
<211> 2413
<212> DNA
<213> Artificial Sequence

<220> 
<223> IgG1 Hinge Stelara

<400> 49
aagcttgtta tccaccatgg agacagacac actcctgcta tgggtactgc tgctctgggt      60

tccaggttcc actggtgacg agcccaaatc ttgtgacaaa actcacacat gcccaccgtg     120

cccagttaac ggcggcggcg gcagcccctt cagagcggcc cagccggccg acatccagat     180

gacccagagc cccagcagcc tgagcgccag cgtgggcgac agagtgacca tcacctgcag     240

agccagccag ggcatcagca gctggctggc ctggtaccag cagaagcccg agaaggcccc     300

caagagcctg atctacgccg ccagcagcct gcagagcggc gtgcccagca gattcagcgg     360

cagcggcagc ggcaccgact tcaccctgac catcagcagc ctgcagcccg aggacttcgc     420

cacctactac tgccagcagt acaacatcta cccctacacc ttcggccagg gcaccaagct     480

ggagatcaag agaactgtgg ctgcaccatc tgtcttcatc ttcccgccat ctgatgagca     540

gttgaaatct ggaactgcct ctgttgtgtg cctgctgaat aacttctatc ccagagaggc     600

caaagtacag tggaaggtgg ataacgccct ccaatcgggt aactcccagg agagtgtcac     660

agagcaggac agcaaggaca gcacctacag cctcagcagc accctgacgc tgagcaaagc     720

agactacgag aaacacaaac tctacgcctg cgaagtcacc catcagggcc tgagctcgcc     780

cgtcacaaag agcttcaaca ggggagagtg cctcgagcga gcaaaacgag caccagtaaa     840

acaaacacta aacttcgacc tactaaaact agcaggagac gtagaatcaa acccaggacc     900

agccacaacc atggagacag acacactcct gctatgggta ctgctgctct gggttccagg     960

ttccactggt gacgagccca aatcttgtga caaaactcac acatgcccac cgtgcccagg    1020

cggccgcggc ggcggcggca gccccttcag aagatctgag gtgcagctgg tgcagagcgg    1080

cgccgaggtg aagaagcccg gcgagagcct gaagatcagc tgcaagggca gcggctacag    1140

cttcaccacc tactggctgg gctgggtgag acagatgccc ggcaagggcc tggactggat    1200

cggcatcatg agccccgtgg acagcgacat cagatacagc cccagcttcc agggccaggt    1260

gaccatgagc gtggacaaga gcatcaccac cgcctacctg cagtggaaca gcctgaaggc    1320

cagcgacacc gccatgtact actgcgccag aagaagaccc ggccagggct acttcgactt    1380

ctggggccag ggcaccctgg tgaccgtgag cagcgcctcc accaagggac catcggtctt    1440

ccccctggca ccctcctcca agagcacctc tgggggcaca gcggccctgg gctgcctggt    1500

caaggactac ttccccgaac cggtgacggt gtcgtggaac tcaggcgccc tgaccagcgg    1560

cgtgcacacc ttcccggctg tcctacagtc ctcaggactc tactccctca gcagcgtggt    1620

gaccgtgccc tccagcagct tgggcaccca gacctacatc tgcaacgtga atcacaagcc    1680

cagcaacacc aaggtcgaca agaaagttga gcccaaatct tgtgacaaaa ctcacacatg    1740

cccaccgtgc ccagcacctg aactcctggg gggaccgtca gtcttcctct tccccccaaa    1800

acccaaggac accctcatga tctcccggac ccctgaggtc acatgcgtgg tggtggacgt    1860

gagccacgaa gaccctgagg tcaagttcaa ctggtacgtg gacggcgtgg aggtgcataa    1920

tgccaagaca aagccgcggg aggagcagta caacagcacg taccgggtgg tcagcgtcct    1980

caccgtcctg caccaggact ggctgaatgg caaggagtac aagtgcaagg tctccaacaa    2040

agccctccca gcccccatcg agaaaaccat ctccaaagcc aaagggcagc cccgagaacc    2100

acaggtgtac accctgcccc catcccggga tgagctgacc aagaaccagg tcagcctgac    2160

ctgcctggtc aaaggcttct atcccagcga catcgccgtg gagtgggaga gcaatgggca    2220

gccggagaac aactacaaga ccacgcctcc cgtgctggac tccgacggct ccttcttcct    2280

ctacagcaag ctcaccgtgg acaagagcag gtggcagcag gggaacgtct tctcatgctc    2340

cgtgatgcat gaggctctgc acaaccacta cacgcagaag agcctctccc tgtctccggg    2400

taaataaatc gat                                                       2413


<210> 50
<211> 2459
<212> DNA
<213> Artificial Sequence

<220> 
<223> IgG1 Hinge Trastuzumab

<400> 50
gctagcaagc ttgttatcca ccatggagac agacacactc ctgctatggg tactgctgct      60

ctgggttcca ggttccactg gtgacgagcc caaatcttgt gacaaaactc acacatgccc     120

accgtgccca gttaacggcg gcggcggcag cggtcccctg ggtgtgagag cggcccagcc     180

ggcgacatcc agatgaccca gagccccagc agcctgagcg ccagcgtggg cgacagagtg     240

accatcacct gcagagccag ccaggacgtg aacaccgccg tggcctggta ccagcagaag     300

cccggcaagg cccccaagct gctgatctac agcgccagct tcctgtacag cggcgtgccc     360

agcagattca gcggcagcag aagcggcacc gacttcaccc tgaccatcag cagcctgcag     420

cccgaggact tcgccaccta ctactgccag cagcactaca ccaccccccc caccttcggc     480

cagggcacca aggtggagat caagagaacc gtggccgccc ccagcgtgtt catcttcccc     540

cccagcgacg agcagctgaa gagcggcacc gccagcgtgg tgtgcctgct gaacaacttc     600

taccccagag aggccaaggt gcagtggaag gtggacaacg ccctgcagag cggcaacagc     660

caggagagcg tgaccgagca ggacagcaag gacagcacct acagcctgag cagcaccctg     720

accctgagca aggccgacta cgagaagcac aaggtgtacg cctgcgaggt gacccaccag     780

ggcctgagca gccccgtgac caagagcttc aacagaggcg agtgcctcga gcgagcaaaa     840

cgagcaccag taaaacaaac actaaacttc gacctactaa aactagcagg agacgtagaa     900

tcaaacccag gaccagccac aaccatggag acagacacac tcctgctatg ggtactgctg     960

ctctgggttc caggttccac tggtgacgag cccaaatctt gtgacaaaac tcacacatgc    1020

ccaccgtgcc caggcggccg cggcggcggc ggcagcggtc ccctgggtgt gagaagatct    1080

gaggtgcagc tggtggagag cggcggcggc ctggtgcagc ccggcggcag cctgagactg    1140

agctgcgccg ccagcggctt caacatcaag gacacctaca tccactgggt gagacaggcc    1200

cccggcaagg gcctggagtg ggtggccaga atctacccca ccaacggcta caccagatac    1260

gccgacagcg tgaagggcag attcaccatc agcgccgaca ccagcaagaa caccgcctac    1320

ctgcagatga acagcctgag agccgaggac accgccgtgt actactgcag cagatggggc    1380

ggcgacggct tctacgccat ggactactgg ggccagggca ccctggtgac cgtgagcagc    1440

gccagcacca agggccccag cgtgttcccc ctggccccca gcagcaagag caccagcggc    1500

ggcaccgccg ccctgggctg cctggtgaag gactacttcc ccgagcccgt gaccgtgagc    1560

tggaacagcg gcgccctgac cagcggcgtg cacaccttcc ccgccgtgct gcagagcagc    1620

ggcctgtaca gcctgagcag cgtggtgacc gtgcccagca gcagcctggg cacccagacc    1680

tacatctgca acgtgaacca caagcccagc aacaccaagg tggacaagaa ggtggtcgac    1740

aagaaagttg agcccaaatc ttgtgacaaa actcacacat gcccaccgtg cccagcacct    1800

gaactcctgg ggggaccgtc agtcttcctc ttccccccaa aacccaagga caccctcatg    1860

atctcccgga cccctgaggt cacatgcgtg gtggtggacg tgagccacga agaccctgag    1920

gtcaagttca actggtacgt ggacggcgtg gaggtgcata atgccaagac aaagccgcgg    1980

gaggagcagt acaacagcac gtaccgggtg gtcagcgtcc tcaccgtcct gcaccaggac    2040

tggctgaatg gcaaggagta caagtgcaag gtctccaaca aagccctccc agcccccatc    2100

gagaaaacca tctccaaagc caaagggcag ccccgagaac cacaggtgta caccctgccc    2160

ccatcccggg atgagctgac caagaaccag gtcagcctga cctgcctggt caaaggcttc    2220

tatcccagcg acatcgccgt ggagtgggag agcaatgggc agccggagaa caactacaag    2280

accacgcctc ccgtgctgga ctccgacggc tccttcttcc tctacagcaa gctcaccgtg    2340

gacaagagca ggtggcagca ggggaacgtc ttctcatgct ccgtgatgca tgaggctctg    2400

cacaaccact acacgcagaa gagcctctcc ctgtctccgg gtaaaatcga tggcgcgcc     2459


<210> 51
<211> 7
<212> PRT
<213> Artificial Sequence

<220> 
<223> MMP2 substrate

<400> 51
Pro Leu Gly Met Trp Ser Arg 
1               5           

<210> 52
<211> 7
<212> PRT
<213> Artificial Sequence

<220> 
<223> MMP2 substrate

<400> 52
Pro Leu Gly Leu Trp Ala Arg 
1               5           

<210> 53
<211> 8
<212> PRT
<213> Artificial Sequence

<220> 
<223> MMP2 substrate

<400> 53
Pro Gln Gly Ile Ala Gly Gln Arg 
1               5               

<210> 54
<211> 35
<212> PRT
<213> Artificial Sequence

<220> 
<223> IgD1 Hinge

<400> 54
Ser Pro Lys Ala Gln Ala Ser Ser Val Pro Thr Ala Gln Pro Gln Ala 
1               5                   10                  15      
Glu Gly Ser Leu Ala Lys Ala Thr Thr Ala Pro Ala Thr Thr Arg Asn 
            20                  25                  30          
Thr Glu Cys 
        35  

<210> 55
<211> 25
<212> PRT
<213> Artificial Sequence

<220> 
<223> IgD2 Hinge

<400> 55
Arg Gly Gly Glu Glu Lys Lys Lys Glu Lys Glu Lys Glu Glu Gln Glu 
1               5                   10                  15      
Glu Arg Glu Thr Lys Thr Pro Glu Cys 
            20                  25  

<210> 56
<211> 105
<212> DNA
<213> Artificial Sequence

<220> 
<223> IgD1 Hinge

<400> 56
tctccaaagg cacaggcctc ctccgtgccc actgcacaac cccaagcaga gggcagcctc     60

gccaaggcaa ccacagcccc agccaccacc cgtaacacag agtgt                    105


<210> 57
<211> 75
<212> DNA
<213> Artificial Sequence

<220> 
<223> IgD2 Hinge

<400> 57
agaggaggag aagagaagaa gaaggagaag gagaaagagg aacaagaaga gagagagaca     60

aagacaccag agtgt                                                      75


<210> 58
<211> 450
<212> PRT
<213> Artificial Sequence

<220> 
<223> infliximab heavy chain

<400> 58
Glu Val Lys Leu Glu Glu Ser Gly Gly Gly Leu Val Gln Pro Gly Gly 
1               5                   10                  15      
Ser Met Lys Leu Ser Cys Val Ala Ser Gly Phe Ile Phe Ser Asn His 
            20                  25                  30          
Trp Met Asn Trp Val Arg Gln Ser Pro Glu Lys Gly Leu Glu Trp Val 
        35                  40                  45              
Ala Glu Ile Arg Ser Lys Ser Ile Asn Ser Ala Thr His Tyr Ala Glu 
    50                  55                  60                  
Ser Val Lys Gly Arg Phe Thr Ile Ser Arg Asp Asp Ser Lys Ser Ala 
65                  70                  75                  80  
Val Tyr Leu Gln Met Thr Asp Leu Arg Thr Glu Asp Thr Gly Val Tyr 
                85                  90                  95      
Tyr Cys Ser Arg Asn Tyr Tyr Gly Ser Thr Tyr Asp Tyr Trp Gly Gln 
            100                 105                 110         
Gly Thr Thr Leu Thr Val Ser Ser Ala Ser Thr Lys Gly Pro Ser Val 
        115                 120                 125             
Phe Pro Leu Ala Pro Ser Ser Lys Ser Thr Ser Gly Gly Thr Ala Ala 
    130                 135                 140                 
Leu Gly Cys Leu Val Lys Asp Tyr Phe Pro Glu Pro Val Thr Val Ser 
145                 150                 155                 160 
Trp Asn Ser Gly Ala Leu Thr Ser Gly Val His Thr Phe Pro Ala Val 
                165                 170                 175     
Leu Gln Ser Ser Gly Leu Tyr Ser Leu Ser Ser Val Val Thr Val Pro 
            180                 185                 190         
Ser Ser Ser Leu Gly Thr Gln Thr Tyr Ile Cys Asn Val Asn His Lys 
        195                 200                 205             
Pro Ser Asn Thr Lys Val Asp Lys Lys Val Glu Pro Lys Ser Cys Asp 
    210                 215                 220                 
Lys Thr His Thr Cys Pro Pro Cys Pro Ala Pro Glu Leu Leu Gly Gly 
225                 230                 235                 240 
Pro Ser Val Phe Leu Phe Pro Pro Lys Pro Lys Asp Thr Leu Met Ile 
                245                 250                 255     
Ser Arg Thr Pro Glu Val Thr Cys Val Val Val Asp Val Ser His Glu 
            260                 265                 270         
Asp Pro Glu Val Lys Phe Asn Trp Tyr Val Asp Gly Val Glu Val His 
        275                 280                 285             
Asn Ala Lys Thr Lys Pro Arg Glu Glu Gln Tyr Asn Ser Thr Tyr Arg 
    290                 295                 300                 
Val Val Ser Val Leu Thr Val Leu His Gln Asp Trp Leu Asn Gly Lys 
305                 310                 315                 320 
Glu Tyr Lys Cys Lys Val Ser Asn Lys Ala Leu Pro Ala Pro Ile Glu 
                325                 330                 335     
Lys Thr Ile Ser Lys Ala Lys Gly Gln Pro Arg Glu Pro Gln Val Tyr 
            340                 345                 350         
Thr Leu Pro Pro Ser Arg Asp Glu Leu Thr Lys Asn Gln Val Ser Leu 
        355                 360                 365             
Thr Cys Leu Val Lys Gly Phe Tyr Pro Ser Asp Ile Ala Val Glu Trp 
    370                 375                 380                 
Glu Ser Asn Gly Gln Pro Glu Asn Asn Tyr Lys Thr Thr Pro Pro Val 
385                 390                 395                 400 
Leu Asp Ser Asp Gly Ser Phe Phe Leu Tyr Ser Lys Leu Thr Val Asp 
                405                 410                 415     
Lys Ser Arg Trp Gln Gln Gly Asn Val Phe Ser Cys Ser Val Met His 
            420                 425                 430         
Glu Ala Leu His Asn His Tyr Thr Gln Lys Ser Leu Ser Leu Ser Pro 
        435                 440                 445             
Gly Lys 
    450 

<210> 59
<211> 385
<212> PRT
<213> Artificial Sequence

<220> 
<223> Panitumumab heavy chain

<400> 59
Gln Val Gln Leu Leu Gln Ser Gly Ala Glu Val Lys Lys Pro Gly Glu 
1               5                   10                  15      
Ser Leu Lys Ile Ser Cys Lys Gly Ser Gly Tyr Ser Phe Thr Ser Tyr 
            20                  25                  30          
Trp Ile Ala Trp Val Arg Gln Met Pro Gly Lys Gly Leu Glu Tyr Met 
        35                  40                  45              
Gly Leu Ile Tyr Pro Gly Asp Ser Asp Thr Lys Tyr Ser Pro Ser Phe 
    50                  55                  60                  
Gln Gly Gln Val Thr Ile Ser Val Asp Lys Ser Val Ser Thr Ala Tyr 
65                  70                  75                  80  
Leu Gln Trp Ser Ser Leu Lys Pro Ser Asp Ser Ala Val Tyr Phe Cys 
                85                  90                  95      
Ala Arg His Asp Val Gly Tyr Cys Ser Ser Ser Asn Cys Ala Lys Trp 
            100                 105                 110         
Pro Glu Tyr Phe Gln His Trp Gly Gln Gly Thr Leu Val Thr Val Ser 
        115                 120                 125             
Ser Ala Ser Thr Lys Gly Pro Ser Val Phe Pro Leu Ala Pro Ser Ser 
    130                 135                 140                 
Lys Ser Thr Ser Gly Gly Thr Ala Ala Leu Gly Cys Leu Val Lys Asp 
145                 150                 155                 160 
Tyr Phe Pro Glu Pro Val Thr Val Ser Trp Asn Ser Gly Ala Leu Thr 
                165                 170                 175     
Ser Gly Val His Thr Phe Pro Ala Val Leu Gln Ser Ser Gly Leu Tyr 
            180                 185                 190         
Ser Leu Ser Ser Val Val Thr Val Pro Ser Ser Ser Leu Gly Thr Gln 
        195                 200                 205             
Thr Tyr Ile Cys Asn Val Asn His Lys Pro Ser Asn Thr Lys Val Asp 
    210                 215                 220                 
Lys Arg Val Val Asp Glu Pro Lys Ser Cys Asp Lys Thr His Thr Cys 
225                 230                 235                 240 
Pro Pro Cys Pro Ala Pro Glu Leu Leu Gly Gly Pro Ser Val Phe Leu 
                245                 250                 255     
Phe Pro Pro Lys Pro Lys Asp Thr Leu Met Ile Ser Arg Thr Pro Glu 
            260                 265                 270         
Val Thr Cys Val Val Val Asp Val Ser His Glu Asp Pro Glu Val Lys 
        275                 280                 285             
Phe Asn Trp Tyr Val Asp Gly Val Glu Val His Asn Ala Lys Thr Lys 
    290                 295                 300                 
Pro Arg Glu Glu Gln Tyr Asn Ser Thr Tyr Arg Val Val Ser Val Leu 
305                 310                 315                 320 
Thr Val Leu His Gln Asp Trp Leu Asn Gly Lys Glu Tyr Lys Cys Lys 
                325                 330                 335     
Val Ser Asn Lys Ala Leu Pro Ala Pro Ile Glu Lys Thr Ile Ser Lys 
            340                 345                 350         
Ala Lys Gly Gln Pro Arg Glu Pro Gln Val Tyr Thr Leu Pro Pro Ser 
        355                 360                 365             
Arg Glu Glu Met Thr Lys Asn Gln Val Ser Leu Thr Cys Leu Val Lys 
    370                 375                 380                 
Gly 
385 

<210> 60
<211> 439
<212> PRT
<213> Artificial Sequence

<220> 
<223> Trastuzumab heavy chain

<400> 60
Val Gln Leu Val Glu Ser Gly Gly Gly Leu Val Gln Pro Gly Gly Ser 
1               5                   10                  15      
Leu Arg Leu Ser Cys Ala Ala Ser Gly Phe Asn Ile Lys Asp Thr Tyr 
            20                  25                  30          
Ile His Trp Val Arg Gln Ala Pro Gly Lys Gly Leu Glu Trp Val Ala 
        35                  40                  45              
Arg Ile Tyr Pro Thr Asn Gly Tyr Thr Arg Tyr Ala Asp Ser Val Lys 
    50                  55                  60                  
Gly Arg Phe Thr Ile Ser Ala Asp Thr Ser Lys Asn Thr Ala Tyr Leu 
65                  70                  75                  80  
Gln Met Asn Ser Leu Arg Ala Glu Asp Thr Ala Val Tyr Tyr Cys Ser 
                85                  90                  95      
Arg Trp Gly Gly Asp Gly Phe Tyr Ala Met Asp Tyr Trp Gly Gln Gly 
            100                 105                 110         
Thr Leu Val Thr Val Ser Ser Ala Ser Thr Lys Gly Pro Ser Val Phe 
        115                 120                 125             
Pro Leu Ala Pro Ser Ser Lys Ser Thr Ser Gly Gly Thr Ala Ala Leu 
    130                 135                 140                 
Gly Cys Leu Val Lys Asp Tyr Phe Pro Glu Pro Val Thr Val Ser Trp 
145                 150                 155                 160 
Asn Ser Gly Ala Leu Thr Ser Gly Val His Thr Phe Pro Ala Val Leu 
                165                 170                 175     
Gln Ser Ser Gly Leu Tyr Ser Leu Ser Ser Val Val Thr Val Pro Ser 
            180                 185                 190         
Ser Ser Leu Gly Thr Gln Thr Tyr Ile Cys Asn Val Asn His Lys Pro 
        195                 200                 205             
Ser Asn Thr Lys Val Asp Lys Lys Val Val Asp Lys Lys Val Glu Pro 
    210                 215                 220                 
Lys Ser Cys Asp Lys Thr His Thr Cys Pro Pro Cys Pro Ala Pro Glu 
225                 230                 235                 240 
Leu Leu Gly Gly Pro Ser Val Phe Leu Phe Pro Pro Lys Pro Lys Asp 
                245                 250                 255     
Thr Leu Met Ile Ser Arg Thr Pro Glu Val Thr Cys Val Val Val Asp 
            260                 265                 270         
Val Ser His Glu Asp Pro Glu Val Lys Phe Asn Trp Tyr Val Asp Gly 
        275                 280                 285             
Val Glu Val His Asn Ala Lys Thr Lys Pro Arg Glu Glu Gln Tyr Asn 
    290                 295                 300                 
Ser Thr Tyr Arg Val Val Ser Val Leu Thr Val Leu His Gln Asp Trp 
305                 310                 315                 320 
Leu Asn Gly Lys Glu Tyr Lys Cys Lys Val Ser Asn Lys Ala Leu Pro 
                325                 330                 335     
Ala Pro Ile Glu Lys Thr Ile Ser Lys Ala Lys Gly Gln Pro Arg Glu 
            340                 345                 350         
Pro Gln Val Tyr Thr Leu Pro Pro Ser Arg Asp Glu Leu Thr Lys Asn 
        355                 360                 365             
Gln Val Ser Leu Thr Cys Leu Val Lys Gly Phe Tyr Pro Ser Asp Ile 
    370                 375                 380                 
Ala Val Glu Trp Glu Ser Asn Gly Gln Pro Glu Asn Asn Tyr Lys Thr 
385                 390                 395                 400 
Thr Pro Pro Val Leu Asp Ser Asp Gly Ser Phe Phe Leu Tyr Ser Lys 
                405                 410                 415     
Leu Thr Val Asp Lys Ser Arg Trp Gln Gln Gly Asn Val Phe Ser Cys 
            420                 425                 430         
Ser Val Met His Glu Ala Leu 
        435                 

<210> 61
<211> 451
<212> PRT
<213> Artificial Sequence

<220> 
<223> adalimumab heavy chain

<400> 61
Glu Val Gln Leu Val Glu Ser Gly Gly Gly Leu Val Gln Pro Gly Arg 
1               5                   10                  15      
Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Phe Thr Phe Asp Asp Tyr 
            20                  25                  30          
Ala Met His Trp Val Arg Gln Ala Pro Gly Lys Gly Leu Glu Trp Val 
        35                  40                  45              
Ser Ala Ile Thr Trp Asn Ser Gly His Ile Asp Tyr Ala Asp Ser Val 
    50                  55                  60                  
Glu Gly Arg Phe Thr Ile Ser Arg Asp Asn Ala Lys Asn Ser Leu Tyr 
65                  70                  75                  80  
Leu Gln Met Asn Ser Leu Arg Ala Glu Asp Thr Ala Val Tyr Tyr Cys 
                85                  90                  95      
Ala Lys Val Ser Tyr Leu Ser Thr Ala Ser Ser Leu Asp Tyr Trp Gly 
            100                 105                 110         
Gln Gly Thr Leu Val Thr Val Ser Ser Ala Ser Thr Lys Gly Pro Ser 
        115                 120                 125             
Val Phe Pro Leu Ala Pro Ser Ser Lys Ser Thr Ser Gly Gly Thr Ala 
    130                 135                 140                 
Ala Leu Gly Cys Leu Val Lys Asp Tyr Phe Pro Glu Pro Val Thr Val 
145                 150                 155                 160 
Ser Trp Asn Ser Gly Ala Leu Thr Ser Gly Val His Thr Phe Pro Ala 
                165                 170                 175     
Val Leu Gln Ser Ser Gly Leu Tyr Ser Leu Ser Ser Val Val Thr Val 
            180                 185                 190         
Pro Ser Ser Ser Leu Gly Thr Gln Thr Tyr Ile Cys Asn Val Asn His 
        195                 200                 205             
Lys Pro Ser Asn Thr Lys Val Asp Lys Lys Val Glu Pro Lys Ser Cys 
    210                 215                 220                 
Asp Lys Thr His Thr Cys Pro Pro Cys Pro Ala Pro Glu Leu Leu Gly 
225                 230                 235                 240 
Gly Pro Ser Val Phe Leu Phe Pro Pro Lys Pro Lys Asp Thr Leu Met 
                245                 250                 255     
Ile Ser Arg Thr Pro Glu Val Thr Cys Val Val Val Asp Val Ser His 
            260                 265                 270         
Glu Asp Pro Glu Val Lys Phe Asn Trp Tyr Val Asp Gly Val Glu Val 
        275                 280                 285             
His Asn Ala Lys Thr Lys Pro Arg Glu Glu Gln Tyr Asn Ser Thr Tyr 
    290                 295                 300                 
Arg Val Val Ser Val Leu Thr Val Leu His Gln Asp Trp Leu Asn Gly 
305                 310                 315                 320 
Lys Glu Tyr Lys Cys Lys Val Ser Asn Lys Ala Leu Pro Ala Pro Ile 
                325                 330                 335     
Glu Lys Thr Ile Ser Lys Ala Lys Gly Gln Pro Arg Glu Pro Gln Val 
            340                 345                 350         
Tyr Thr Leu Pro Pro Ser Arg Asp Glu Leu Thr Lys Asn Gln Val Ser 
        355                 360                 365             
Leu Thr Cys Leu Val Lys Gly Phe Tyr Pro Ser Asp Ile Ala Val Glu 
    370                 375                 380                 
Trp Glu Ser Asn Gly Gln Pro Glu Asn Asn Tyr Lys Thr Thr Pro Pro 
385                 390                 395                 400 
Val Leu Asp Ser Asp Gly Ser Phe Phe Leu Tyr Ser Lys Leu Thr Val 
                405                 410                 415     
Asp Lys Ser Arg Trp Gln Gln Gly Asn Val Phe Ser Cys Ser Val Met 
            420                 425                 430         
His Glu Ala Leu His Asn His Tyr Thr Gln Lys Ser Leu Ser Leu Ser 
        435                 440                 445             
Pro Gly Lys 
    450     

<210> 62
<211> 448
<212> PRT
<213> Artificial Sequence

<220> 
<223> denosumab heavy chain

<400> 62
Glu Val Gln Leu Leu Glu Ser Gly Gly Gly Leu Val Gln Pro Gly Gly 
1               5                   10                  15      
Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Phe Thr Phe Ser Ser Tyr 
            20                  25                  30          
Ala Met Ser Trp Val Arg Gln Ala Pro Gly Lys Gly Leu Glu Trp Val 
        35                  40                  45              
Ser Gly Ile Thr Gly Ser Gly Gly Ser Thr Tyr Tyr Ala Asp Ser Val 
    50                  55                  60                  
Lys Gly Arg Phe Thr Ile Ser Arg Asp Asn Ser Lys Asn Thr Leu Tyr 
65                  70                  75                  80  
Leu Gln Met Asn Ser Leu Arg Ala Glu Asp Thr Ala Val Tyr Tyr Cys 
                85                  90                  95      
Ala Lys Asp Pro Gly Thr Thr Val Ile Met Ser Trp Phe Asp Pro Trp 
            100                 105                 110         
Gly Gln Gly Thr Leu Val Thr Val Ser Ser Ala Ser Thr Lys Gly Pro 
        115                 120                 125             
Ser Val Phe Pro Leu Ala Pro Cys Ser Arg Ser Thr Ser Glu Ser Thr 
    130                 135                 140                 
Ala Ala Leu Gly Cys Leu Val Lys Asp Tyr Phe Pro Glu Pro Val Thr 
145                 150                 155                 160 
Val Ser Trp Asn Ser Gly Ala Leu Thr Ser Gly Val His Thr Phe Pro 
                165                 170                 175     
Ala Val Leu Gln Ser Ser Gly Leu Tyr Ser Leu Ser Ser Val Val Thr 
            180                 185                 190         
Val Pro Ser Ser Asn Phe Gly Thr Gln Thr Tyr Thr Cys Asn Val Asp 
        195                 200                 205             
His Lys Pro Ser Asn Thr Lys Val Asp Lys Thr Val Glu Arg Lys Cys 
    210                 215                 220                 
Cys Val Glu Cys Pro Pro Cys Pro Ala Pro Pro Val Ala Gly Pro Ser 
225                 230                 235                 240 
Val Phe Leu Phe Pro Pro Lys Pro Lys Asp Thr Leu Met Ile Ser Arg 
                245                 250                 255     
Thr Pro Glu Val Thr Cys Val Val Val Asp Val Ser His Glu Asp Pro 
            260                 265                 270         
Glu Val Gln Phe Asn Trp Tyr Val Asp Gly Val Glu Val His Asn Ala 
        275                 280                 285             
Lys Thr Lys Pro Arg Glu Glu Gln Phe Asn Ser Thr Phe Arg Val Val 
    290                 295                 300                 
Ser Val Leu Thr Val Val His Gln Asp Trp Leu Asn Gly Lys Glu Tyr 
305                 310                 315                 320 
Lys Cys Lys Val Ser Asn Lys Gly Leu Pro Ala Pro Ile Glu Lys Thr 
                325                 330                 335     
Ile Ser Lys Thr Lys Gly Gln Pro Arg Glu Pro Gln Val Tyr Thr Leu 
            340                 345                 350         
Pro Pro Ser Arg Glu Glu Met Thr Lys Asn Gln Val Ser Leu Thr Cys 
        355                 360                 365             
Leu Val Lys Gly Phe Tyr Pro Ser Asp Ile Ala Val Glu Trp Glu Ser 
    370                 375                 380                 
Asn Gly Gln Pro Glu Asn Asn Tyr Lys Thr Thr Pro Pro Met Leu Asp 
385                 390                 395                 400 
Ser Asp Gly Ser Phe Phe Leu Tyr Ser Lys Leu Thr Val Asp Lys Ser 
                405                 410                 415     
Arg Trp Gln Gln Gly Asn Val Phe Ser Cys Ser Val Met His Glu Ala 
            420                 425                 430         
Leu His Asn His Tyr Thr Gln Lys Ser Leu Ser Leu Ser Pro Gly Lys 
        435                 440                 445             



<210> 63
<211> 448
<212> PRT
<213> Artificial Sequence

<220> 
<223> Ipilimumab heavy chain

<400> 63
Gln Val Gln Leu Val Glu Ser Gly Gly Gly Val Val Gln Pro Gly Arg 
1               5                   10                  15      
Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Phe Thr Phe Ser Ser Tyr 
            20                  25                  30          
Thr Met His Trp Val Arg Gln Ala Pro Gly Lys Gly Leu Glu Trp Val 
        35                  40                  45              
Thr Phe Ile Ser Tyr Asp Gly Asn Asn Lys Tyr Tyr Ala Asp Ser Val 
    50                  55                  60                  
Lys Gly Arg Phe Thr Ile Ser Arg Asp Asn Ser Lys Asn Thr Leu Tyr 
65                  70                  75                  80  
Leu Gln Met Asn Ser Leu Arg Ala Glu Asp Thr Ala Ile Tyr Tyr Cys 
                85                  90                  95      
Ala Arg Thr Gly Trp Leu Gly Pro Phe Asp Tyr Trp Gly Gln Gly Thr 
            100                 105                 110         
Leu Val Thr Val Ser Ser Ala Ser Thr Lys Gly Pro Ser Val Phe Pro 
        115                 120                 125             
Leu Ala Pro Ser Ser Lys Ser Thr Ser Gly Gly Thr Ala Ala Leu Gly 
    130                 135                 140                 
Cys Leu Val Lys Asp Tyr Phe Pro Glu Pro Val Thr Val Ser Trp Asn 
145                 150                 155                 160 
Ser Gly Ala Leu Thr Ser Gly Val His Thr Phe Pro Ala Val Leu Gln 
                165                 170                 175     
Ser Ser Gly Leu Tyr Ser Leu Ser Ser Val Val Thr Val Pro Ser Ser 
            180                 185                 190         
Ser Leu Gly Thr Gln Thr Tyr Ile Cys Asn Val Asn His Lys Pro Ser 
        195                 200                 205             
Asn Thr Lys Val Asp Lys Lys Val Glu Pro Lys Ser Cys Asp Lys Thr 
    210                 215                 220                 
His Thr Cys Pro Pro Cys Pro Ala Pro Glu Leu Leu Gly Gly Pro Ser 
225                 230                 235                 240 
Val Phe Leu Phe Pro Pro Lys Pro Lys Asp Thr Leu Met Ile Ser Arg 
                245                 250                 255     
Thr Pro Glu Val Thr Cys Val Val Val Asp Val Ser His Glu Asp Pro 
            260                 265                 270         
Glu Val Lys Phe Asn Trp Tyr Val Asp Gly Val Glu Val His Asn Ala 
        275                 280                 285             
Lys Thr Lys Pro Arg Glu Glu Gln Tyr Asn Ser Thr Tyr Arg Val Val 
    290                 295                 300                 
Ser Val Leu Thr Val Leu His Gln Asp Trp Leu Asn Gly Lys Glu Tyr 
305                 310                 315                 320 
Lys Cys Lys Val Ser Asn Lys Ala Leu Pro Ala Pro Ile Glu Lys Thr 
                325                 330                 335     
Ile Ser Lys Ala Lys Gly Gln Pro Arg Glu Pro Gln Val Tyr Thr Leu 
            340                 345                 350         
Pro Pro Ser Arg Asp Glu Leu Thr Lys Asn Gln Val Ser Leu Thr Cys 
        355                 360                 365             
Leu Val Lys Gly Phe Tyr Pro Ser Asp Ile Ala Val Glu Trp Glu Ser 
    370                 375                 380                 
Asn Gly Gln Pro Glu Asn Asn Tyr Lys Thr Thr Pro Pro Val Leu Asp 
385                 390                 395                 400 
Ser Asp Gly Ser Phe Phe Leu Tyr Ser Lys Leu Thr Val Asp Lys Ser 
                405                 410                 415     
Arg Trp Gln Gln Gly Asn Val Phe Ser Cys Ser Val Met His Glu Ala 
            420                 425                 430         
Leu His Asn His Tyr Thr Gln Lys Ser Leu Ser Leu Ser Pro Gly Lys 
        435                 440                 445             



<210> 64
<211> 451
<212> PRT
<213> Artificial Sequence

<220> 
<223> tremelimumab heavy chain

<400> 64
Gln Val Gln Leu Val Glu Ser Gly Gly Gly Val Val Gln Pro Gly Arg 
1               5                   10                  15      
Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Phe Thr Phe Ser Ser Tyr 
            20                  25                  30          
Gly Met His Trp Val Arg Gln Ala Pro Gly Lys Gly Leu Glu Trp Val 
        35                  40                  45              
Ala Val Ile Trp Tyr Asp Gly Ser Asn Lys Tyr Tyr Ala Asp Ser Val 
    50                  55                  60                  
Lys Gly Arg Phe Thr Ile Ser Arg Asp Asn Ser Lys Asn Thr Leu Tyr 
65                  70                  75                  80  
Leu Gln Met Asn Ser Leu Arg Ala Glu Asp Thr Ala Val Tyr Tyr Cys 
                85                  90                  95      
Ala Arg Asp Pro Arg Gly Ala Thr Leu Tyr Tyr Tyr Tyr Tyr Gly Met 
            100                 105                 110         
Asp Val Trp Gly Gln Gly Thr Thr Val Thr Val Ser Ser Ala Ser Thr 
        115                 120                 125             
Lys Gly Pro Ser Val Phe Pro Leu Ala Pro Cys Ser Arg Ser Thr Ser 
    130                 135                 140                 
Glu Ser Thr Ala Ala Leu Gly Cys Leu Val Lys Asp Tyr Phe Pro Glu 
145                 150                 155                 160 
Pro Val Thr Val Ser Trp Asn Ser Gly Ala Leu Thr Ser Gly Val His 
                165                 170                 175     
Thr Phe Pro Ala Val Leu Gln Ser Ser Gly Leu Tyr Ser Leu Ser Ser 
            180                 185                 190         
Val Val Thr Val Pro Ser Ser Asn Phe Gly Thr Gln Thr Tyr Thr Cys 
        195                 200                 205             
Asn Val Asp His Lys Pro Ser Asn Thr Lys Val Asp Lys Thr Val Glu 
    210                 215                 220                 
Arg Lys Cys Cys Val Glu Cys Pro Pro Cys Pro Ala Pro Pro Val Ala 
225                 230                 235                 240 
Gly Pro Ser Val Phe Leu Phe Pro Pro Lys Pro Lys Asp Thr Leu Met 
                245                 250                 255     
Ile Ser Arg Thr Pro Glu Val Thr Cys Val Val Val Asp Val Ser His 
            260                 265                 270         
Glu Asp Pro Glu Val Gln Phe Asn Trp Tyr Val Asp Gly Val Glu Val 
        275                 280                 285             
His Asn Ala Lys Thr Lys Pro Arg Glu Glu Gln Phe Asn Ser Thr Phe 
    290                 295                 300                 
Arg Val Val Ser Val Leu Thr Val Val His Gln Asp Trp Leu Asn Gly 
305                 310                 315                 320 
Lys Glu Tyr Lys Cys Lys Val Ser Asn Lys Gly Leu Pro Ala Pro Ile 
                325                 330                 335     
Glu Lys Thr Ile Ser Lys Thr Lys Gly Gln Pro Arg Glu Pro Gln Val 
            340                 345                 350         
Tyr Thr Leu Pro Pro Ser Arg Glu Glu Met Thr Lys Asn Gln Val Ser 
        355                 360                 365             
Leu Thr Cys Leu Val Lys Gly Phe Tyr Pro Ser Asp Ile Ala Val Glu 
    370                 375                 380                 
Trp Glu Ser Asn Gly Gln Pro Glu Asn Asn Tyr Lys Thr Thr Pro Pro 
385                 390                 395                 400 
Met Leu Asp Ser Asp Gly Ser Phe Phe Leu Tyr Ser Lys Leu Thr Val 
                405                 410                 415     
Asp Lys Ser Arg Trp Gln Gln Gly Asn Val Phe Ser Cys Ser Val Met 
            420                 425                 430         
His Glu Ala Leu His Asn His Tyr Thr Gln Lys Ser Leu Ser Leu Ser 
        435                 440                 445             
Pro Gly Lys 
    450     

<210> 65
<211> 451
<212> PRT
<213> Artificial Sequence

<220> 
<223> efalizumab heavy chain

<400> 65
Glu Val Gln Leu Val Glu Ser Gly Gly Gly Leu Val Gln Pro Gly Gly 
1               5                   10                  15      
Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Tyr Ser Phe Thr Gly His 
            20                  25                  30          
Trp Met Asn Trp Val Arg Gln Ala Pro Gly Lys Gly Leu Glu Trp Val 
        35                  40                  45              
Gly Met Ile His Pro Ser Asp Ser Glu Thr Arg Tyr Asn Gln Lys Phe 
    50                  55                  60                  
Lys Asp Arg Phe Thr Ile Ser Val Asp Lys Ser Lys Asn Thr Leu Tyr 
65                  70                  75                  80  
Leu Gln Met Asn Ser Leu Arg Ala Glu Asp Thr Ala Val Tyr Tyr Cys 
                85                  90                  95      
Ala Arg Gly Ile Tyr Phe Tyr Gly Thr Thr Tyr Phe Asp Tyr Trp Gly 
            100                 105                 110         
Gln Gly Thr Leu Val Thr Val Ser Ser Ala Ser Thr Lys Gly Pro Ser 
        115                 120                 125             
Val Phe Pro Leu Ala Pro Ser Ser Lys Ser Thr Ser Gly Gly Thr Ala 
    130                 135                 140                 
Ala Leu Gly Cys Leu Val Lys Asp Tyr Phe Pro Glu Pro Val Thr Val 
145                 150                 155                 160 
Ser Trp Asn Ser Gly Ala Leu Thr Ser Gly Val His Thr Phe Pro Ala 
                165                 170                 175     
Val Leu Gln Ser Ser Gly Leu Tyr Ser Leu Ser Ser Val Val Thr Val 
            180                 185                 190         
Pro Ser Ser Ser Leu Gly Thr Gln Thr Tyr Ile Cys Asn Val Asn His 
        195                 200                 205             
Lys Pro Ser Asn Thr Lys Val Asp Lys Lys Val Glu Pro Lys Ser Cys 
    210                 215                 220                 
Asp Lys Thr His Thr Cys Pro Pro Cys Pro Ala Pro Glu Leu Leu Gly 
225                 230                 235                 240 
Gly Pro Ser Val Phe Leu Phe Pro Pro Lys Pro Lys Asp Thr Leu Met 
                245                 250                 255     
Ile Ser Arg Thr Pro Glu Val Thr Cys Val Val Val Asp Val Ser His 
            260                 265                 270         
Glu Asp Pro Glu Val Lys Phe Asn Trp Tyr Val Asp Gly Val Glu Val 
        275                 280                 285             
His Asn Ala Lys Thr Lys Pro Arg Glu Glu Gln Tyr Asn Ser Thr Tyr 
    290                 295                 300                 
Arg Val Val Ser Val Leu Thr Val Leu His Gln Asp Trp Leu Asn Gly 
305                 310                 315                 320 
Lys Glu Tyr Lys Cys Lys Val Ser Asn Lys Ala Leu Pro Ala Pro Ile 
                325                 330                 335     
Glu Lys Thr Ile Ser Lys Ala Lys Gly Gln Pro Arg Glu Pro Gln Val 
            340                 345                 350         
Tyr Thr Leu Pro Pro Ser Arg Asp Glu Leu Thr Lys Asn Gln Val Ser 
        355                 360                 365             
Leu Thr Cys Leu Val Lys Gly Phe Tyr Pro Ser Asp Ile Ala Val Glu 
    370                 375                 380                 
Trp Glu Ser Asn Gly Gln Pro Glu Asn Asn Tyr Lys Thr Thr Pro Pro 
385                 390                 395                 400 
Val Leu Asp Ser Asp Gly Ser Phe Phe Leu Tyr Ser Lys Leu Thr Val 
                405                 410                 415     
Asp Lys Ser Arg Trp Gln Gln Gly Asn Val Phe Ser Cys Ser Val Met 
            420                 425                 430         
His Glu Ala Leu His Asn His Tyr Thr Gln Lys Ser Leu Ser Leu Ser 
        435                 440                 445             
Pro Gly Lys 
    450     

<210> 66
<211> 449
<212> PRT
<213> Artificial Sequence

<220> 
<223> ustekinumab heavy chain

<400> 66
Glu Val Gln Leu Val Gln Ser Gly Ala Glu Val Lys Lys Pro Gly Glu 
1               5                   10                  15      
Ser Leu Lys Ile Ser Cys Lys Gly Ser Gly Tyr Ser Phe Thr Thr Tyr 
            20                  25                  30          
Trp Leu Gly Trp Val Arg Gln Met Pro Gly Lys Gly Leu Asp Trp Ile 
        35                  40                  45              
Gly Ile Met Ser Pro Val Asp Ser Asp Ile Arg Tyr Ser Pro Ser Phe 
    50                  55                  60                  
Gln Gly Gln Val Thr Met Ser Val Asp Lys Ser Ile Thr Thr Ala Tyr 
65                  70                  75                  80  
Leu Gln Trp Asn Ser Leu Lys Ala Ser Asp Thr Ala Met Tyr Tyr Cys 
                85                  90                  95      
Ala Arg Arg Arg Pro Gly Gln Gly Tyr Phe Asp Phe Trp Gly Gln Gly 
            100                 105                 110         
Thr Leu Val Thr Val Ser Ser Ala Ser Thr Lys Gly Pro Ser Val Phe 
        115                 120                 125             
Pro Leu Ala Pro Ser Ser Lys Ser Thr Ser Gly Gly Thr Ala Ala Leu 
    130                 135                 140                 
Gly Cys Leu Val Lys Asp Tyr Phe Pro Glu Pro Val Thr Val Ser Trp 
145                 150                 155                 160 
Asn Ser Gly Ala Leu Thr Ser Gly Val His Thr Phe Pro Ala Val Leu 
                165                 170                 175     
Gln Ser Ser Gly Leu Tyr Ser Leu Ser Ser Val Val Thr Val Pro Ser 
            180                 185                 190         
Ser Ser Leu Gly Thr Gln Thr Tyr Ile Cys Asn Val Asn His Lys Pro 
        195                 200                 205             
Ser Asn Thr Lys Val Asp Lys Lys Val Glu Pro Lys Ser Cys Asp Lys 
    210                 215                 220                 
Thr His Thr Cys Pro Pro Cys Pro Ala Pro Glu Leu Leu Gly Gly Pro 
225                 230                 235                 240 
Ser Val Phe Leu Phe Pro Pro Lys Pro Lys Asp Thr Leu Met Ile Ser 
                245                 250                 255     
Arg Thr Pro Glu Val Thr Cys Val Val Val Asp Val Ser His Glu Asp 
            260                 265                 270         
Pro Glu Val Lys Phe Asn Trp Tyr Val Asp Gly Val Glu Val His Asn 
        275                 280                 285             
Ala Lys Thr Lys Pro Arg Glu Glu Gln Tyr Asn Ser Thr Tyr Arg Val 
    290                 295                 300                 
Val Ser Val Leu Thr Val Leu His Gln Asp Trp Leu Asn Gly Lys Glu 
305                 310                 315                 320 
Tyr Lys Cys Lys Val Ser Asn Lys Ala Leu Pro Ala Pro Ile Glu Lys 
                325                 330                 335     
Thr Ile Ser Lys Ala Lys Gly Gln Pro Arg Glu Pro Gln Val Tyr Thr 
            340                 345                 350         
Leu Pro Pro Ser Arg Asp Glu Leu Thr Lys Asn Gln Val Ser Leu Thr 
        355                 360                 365             
Cys Leu Val Lys Gly Phe Tyr Pro Ser Asp Ile Ala Val Glu Trp Glu 
    370                 375                 380                 
Ser Asn Gly Gln Pro Glu Asn Asn Tyr Lys Thr Thr Pro Pro Val Leu 
385                 390                 395                 400 
Asp Ser Asp Gly Ser Phe Phe Leu Tyr Ser Lys Leu Thr Val Asp Lys 
                405                 410                 415     
Ser Arg Trp Gln Gln Gly Asn Val Phe Ser Cys Ser Val Met His Glu 
            420                 425                 430         
Ala Leu His Asn His Tyr Thr Gln Lys Ser Leu Ser Leu Ser Pro Gly 
        435                 440                 445             
Lys 
    

<210> 67
<211> 744
<212> DNA
<213> Artificial Sequence

<220> 
<223> IgG1 Hinge+ Ipilimumab light chain

<400> 67
gagcccaaat cttgtgacaa aactcacaca tgcccaccgt gcccagttaa cggcggcggc      60

ggcagcggtc ccctgggtgt gagagcggcc cagccggccg aaattgtgtt gacgcagtct     120

ccaggcaccc tgtctttgtc tccaggggaa agagccaccc tctcctgcag ggccagtcag     180

agtgttggca gcagctactt agcctggtac cagcagaaac ctggccaggc tcccaggctc     240

ctcatctatg gtgcattcag cagggccact ggcatcccag acaggttcag tggcagtggg     300

tctgggacag acttcactct caccatcagc agactggagc ctgaagattt tgcagtgtat     360

tactgtcagc agtatggtag ctcaccgtgg acgttcggcc aagggaccaa ggtggaaatc     420

aaacggactg tggctgcacc atctgtcttc atcttcccgc catctgatga gcagttgaaa     480

tctggaactg cctctgttgt gtgcctgctg aataacttct atcccagaga ggccaaagta     540

cagtggaagg tggataacgc cctccaatcg ggtaactccc aggagagtgt cacagagcag     600

gacagcaagg acagcaccta cagcctcagc agcaccctga cgctgagcaa agcagactac     660

gagaaacaca aactctacgc ctgcgaagtc acccatcagg gcctgagctc gcccgtcaca     720

aagagcttca acaggggaga gtgc                                            744


<210> 68
<211> 1440
<212> DNA
<213> Artificial Sequence

<220> 
<223> IgG1 Hinge+ Ipilimumab heavy chain

<400> 68
gagcccaaat cttgtgacaa aactcacaca tgcccaccgt gcccaggcgg ccgcggcggc      60

ggcggcagcg gtcccctggg tgtgagaaga tctcaggtgc agctggtgga gtctggggga     120

ggcgtggtcc agcctgggag gtccctgaga ctctcctgtg cagcctctgg attcaccttc     180

agtagctata ctatgcactg ggtccgccag gctccaggca aggggctgga gtgggtgaca     240

tttatatcat atgatggaaa caataaatac tacgcagact ccgtgaaggg ccgattcacc     300

atctccagag acaattccaa gaacacgctg tatctgcaaa tgaacagcct gagagctgag     360

gacacggcta tatattactg tgcgaggacc ggctggctgg ggccctttga ctactggggc     420

cagggaaccc tggtcaccgt ctcctcagcc tccaccaagg gaccatcggt cttccccctg     480

gcaccctcct ccaagagcac ctctgggggc acagcggccc tgggctgcct ggtcaaggac     540

tacttccccg aaccggtgac ggtgtcgtgg aactcaggcg ccctgaccag cggcgtgcac     600

accttcccgg ctgtcctaca gtcctcagga ctctactccc tcagcagcgt ggtgaccgtg     660

ccctccagca gcttgggcac ccagacctac atctgcaacg tgaatcacaa gcccagcaac     720

accaaggtcg acaagaaagt tgagcccaaa tcttgtgaca aaactcacac atgcccaccg     780

tgcccagcac ccgaactcct ggggggaccg tcagtcttcc tcttcccccc aaaacccaag     840

gacaccctca tgatctcccg gacccctgag gtcacatgcg tggtggtgga cgtgagccac     900

gaagaccctg aggtcaagtt caactggtac gtggacggcg tggaggtgca taatgccaag     960

acaaagccgc gggaggagca gtacaacagc acgtaccgtg tggtcagcgt cctcaccgtc    1020

ctgcaccagg actggctgaa tggcaaggag tacaagtgca aggtctccaa caaagccctc    1080

ccagccccca tcgagaaaac catctccaaa gccaaggggc agccccgaga accacaggtg    1140

tacaccctgc ccccatcccg ggatgagctg accaagaacc aggtcagcct gacctgcctg    1200

gtcaaaggct tctatcccag cgacatcgcc gtggagtggg agagcaatgg gcagccggag    1260

aacaactaca agaccacgcc tcccgtgctg gactccgacg gctccttctt cctctacagc    1320

aagctcaccg tggacaagag caggtggcag caggggaacg tcttctcatg ctccgtgatg    1380

catgaggctc tgcacaacca ctacacgcag aagagcctct ccctgtctcc gggtaaataa    1440


<210> 69
<211> 735
<212> DNA
<213> Artificial Sequence

<220> 
<223> IgG2 Hinge+ Ipilimumab light chain

<400> 69
gagcgcaaat gttgtgtcga gtgcccaccg tgcccagtta acggcggcgg cggcagcggt      60

cccctgggtg tgagagcggc ccagccggcc gaaattgtgt tgacgcagtc tccaggcacc     120

ctgtctttgt ctccagggga aagagccacc ctctcctgca gggccagtca gagtgttggc     180

agcagctact tagcctggta ccagcagaaa cctggccagg ctcccaggct cctcatctat     240

ggtgcattca gcagggccac tggcatccca gacaggttca gtggcagtgg gtctgggaca     300

gacttcactc tcaccatcag cagactggag cctgaagatt ttgcagtgta ttactgtcag     360

cagtatggta gctcaccgtg gacgttcggc caagggacca aggtggaaat caaacggact     420

gtggctgcac catctgtctt catcttcccg ccatctgatg agcagttgaa atctggaact     480

gcctctgttg tgtgcctgct gaataacttc tatcccagag aggccaaagt acagtggaag     540

gtggataacg ccctccaatc gggtaactcc caggagagtg tcacagagca ggacagcaag     600

gacagcacct acagcctcag cagcaccctg acgctgagca aagcagacta cgagaaacac     660

aaactctacg cctgcgaagt cacccatcag ggcctgagct cgcccgtcac aaagagcttc     720

aacaggggag agtgc                                                      735


<210> 70
<211> 1431
<212> DNA
<213> Artificial Sequence

<220> 
<223> IgG2 Hinge+ Ipilimumab heavy chain

<400> 70
gagcgcaaat gttgtgtcga gtgcccaccg tgcccaggcg gccgcggcgg cggcggcagc      60

ggtcccctgg gtgtgagaag atctcaggtg cagctggtgg agtctggggg aggcgtggtc     120

cagcctggga ggtccctgag actctcctgt gcagcctctg gattcacctt cagtagctat     180

actatgcact gggtccgcca ggctccaggc aaggggctgg agtgggtgac atttatatca     240

tatgatggaa acaataaata ctacgcagac tccgtgaagg gccgattcac catctccaga     300

gacaattcca agaacacgct gtatctgcaa atgaacagcc tgagagctga ggacacggct     360

atatattact gtgcgaggac cggctggctg gggccctttg actactgggg ccagggaacc     420

ctggtcaccg tctcctcagc ctccaccaag ggaccatcgg tcttccccct ggcaccctcc     480

tccaagagca cctctggggg cacagcggcc ctgggctgcc tggtcaagga ctacttcccc     540

gaaccggtga cggtgtcgtg gaactcaggc gccctgacca gcggcgtgca caccttcccg     600

gctgtcctac agtcctcagg actctactcc ctcagcagcg tggtgaccgt gccctccagc     660

agcttgggca cccagaccta catctgcaac gtgaatcaca agcccagcaa caccaaggtc     720

gacaagaaag ttgagcccaa atcttgtgac aaaactcaca catgcccacc gtgcccagca     780

cccgaactcc tggggggacc gtcagtcttc ctcttccccc caaaacccaa ggacaccctc     840

atgatctccc ggacccctga ggtcacatgc gtggtggtgg acgtgagcca cgaagaccct     900

gaggtcaagt tcaactggta cgtggacggc gtggaggtgc ataatgccaa gacaaagccg     960

cgggaggagc agtacaacag cacgtaccgt gtggtcagcg tcctcaccgt cctgcaccag    1020

gactggctga atggcaagga gtacaagtgc aaggtctcca acaaagccct cccagccccc    1080

atcgagaaaa ccatctccaa agccaagggg cagccccgag aaccacaggt gtacaccctg    1140

cccccatccc gggatgagct gaccaagaac caggtcagcc tgacctgcct ggtcaaaggc    1200

ttctatccca gcgacatcgc cgtggagtgg gagagcaatg ggcagccgga gaacaactac    1260

aagaccacgc ctcccgtgct ggactccgac ggctccttct tcctctacag caagctcacc    1320

gtggacaaga gcaggtggca gcaggggaac gtcttctcat gctccgtgat gcatgaggct    1380

ctgcacaacc actacacgca gaagagcctc tccctgtctc cgggtaaata a             1431


<210> 71
<211> 885
<212> DNA
<213> Artificial Sequence

<220> 
<223> IgG3 Hinge+ Ipilimumab light chain

<400> 71
gagctcaaaa ccccacttgg tgacacaact cacacatgcc cacggtgccc agagcccaaa      60

tcttgtgaca cacctccccc gtgcccacgg tgcccagagc ccaaatcttg tgacacacct     120

cccccatgcc cacggtgccc agagcccaaa tcttgtgaca cacctccccc gtgcccaagg     180

tgcccagtta acggcggcgg cggcagcggt cccctgggtg tgagagcggc ccagccggcc     240

gaaattgtgt tgacgcagtc tccaggcacc ctgtctttgt ctccagggga aagagccacc     300

ctctcctgca gggccagtca gagtgttggc agcagctact tagcctggta ccagcagaaa     360

cctggccagg ctcccaggct cctcatctat ggtgcattca gcagggccac tggcatccca     420

gacaggttca gtggcagtgg gtctgggaca gacttcactc tcaccatcag cagactggag     480

cctgaagatt ttgcagtgta ttactgtcag cagtatggta gctcaccgtg gacgttcggc     540

caagggacca aggtggaaat caaacggact gtggctgcac catctgtctt catcttcccg     600

ccatctgatg agcagttgaa atctggaact gcctctgttg tgtgcctgct gaataacttc     660

tatcccagag aggccaaagt acagtggaag gtggataacg ccctccaatc gggtaactcc     720

caggagagtg tcacagagca ggacagcaag gacagcacct acagcctcag cagcaccctg     780

acgctgagca aagcagacta cgagaaacac aaactctacg cctgcgaagt cacccatcag     840

ggcctgagct cgcccgtcac aaagagcttc aacaggggag agtgc                     885


<210> 72
<211> 1581
<212> DNA
<213> Artificial Sequence

<220> 
<223> IgG3 Hinge+ Ipilimumab heavy chain

<400> 72
gagctcaaaa ccccacttgg tgacacaact cacacatgcc cacggtgccc agagcccaaa      60

tcttgtgaca cacctccccc gtgcccacgg tgcccagagc ccaaatcttg tgacacacct     120

cccccatgcc cacggtgccc agagcccaaa tcttgtgaca cacctccccc gtgcccaagg     180

tgcccaggcg gccgcggcgg cggcggcagc ggtcccctgg gtgtgagaag atctcaggtg     240

cagctggtgg agtctggggg aggcgtggtc cagcctggga ggtccctgag actctcctgt     300

gcagcctctg gattcacctt cagtagctat actatgcact gggtccgcca ggctccaggc     360

aaggggctgg agtgggtgac atttatatca tatgatggaa acaataaata ctacgcagac     420

tccgtgaagg gccgattcac catctccaga gacaattcca agaacacgct gtatctgcaa     480

atgaacagcc tgagagctga ggacacggct atatattact gtgcgaggac cggctggctg     540

gggccctttg actactgggg ccagggaacc ctggtcaccg tctcctcagc ctccaccaag     600

ggaccatcgg tcttccccct ggcaccctcc tccaagagca cctctggggg cacagcggcc     660

ctgggctgcc tggtcaagga ctacttcccc gaaccggtga cggtgtcgtg gaactcaggc     720

gccctgacca gcggcgtgca caccttcccg gctgtcctac agtcctcagg actctactcc     780

ctcagcagcg tggtgaccgt gccctccagc agcttgggca cccagaccta catctgcaac     840

gtgaatcaca agcccagcaa caccaaggtc gacaagaaag ttgagcccaa atcttgtgac     900

aaaactcaca catgcccacc gtgcccagca cccgaactcc tggggggacc gtcagtcttc     960

ctcttccccc caaaacccaa ggacaccctc atgatctccc ggacccctga ggtcacatgc    1020

gtggtggtgg acgtgagcca cgaagaccct gaggtcaagt tcaactggta cgtggacggc    1080

gtggaggtgc ataatgccaa gacaaagccg cgggaggagc agtacaacag cacgtaccgt    1140

gtggtcagcg tcctcaccgt cctgcaccag gactggctga atggcaagga gtacaagtgc    1200

aaggtctcca acaaagccct cccagccccc atcgagaaaa ccatctccaa agccaagggg    1260

cagccccgag aaccacaggt gtacaccctg cccccatccc gggatgagct gaccaagaac    1320

caggtcagcc tgacctgcct ggtcaaaggc ttctatccca gcgacatcgc cgtggagtgg    1380

gagagcaatg ggcagccgga gaacaactac aagaccacgc ctcccgtgct ggactccgac    1440

ggctccttct tcctctacag caagctcacc gtggacaaga gcaggtggca gcaggggaac    1500

gtcttctcat gctccgtgat gcatgaggct ctgcacaacc actacacgca gaagagcctc    1560

tccctgtctc cgggtaaata a                                              1581


<210> 73
<211> 735
<212> DNA
<213> Artificial Sequence

<220> 
<223> IgG4 Hinge+ Ipilimumab light chain

<400> 73
gagtccaaat atggtccccc atgcccatca tgcccagtta acggcggcgg cggcagcggt      60

cccctgggtg tgagagcggc ccagccggcc gaaattgtgt tgacgcagtc tccaggcacc     120

ctgtctttgt ctccagggga aagagccacc ctctcctgca gggccagtca gagtgttggc     180

agcagctact tagcctggta ccagcagaaa cctggccagg ctcccaggct cctcatctat     240

ggtgcattca gcagggccac tggcatccca gacaggttca gtggcagtgg gtctgggaca     300

gacttcactc tcaccatcag cagactggag cctgaagatt ttgcagtgta ttactgtcag     360

cagtatggta gctcaccgtg gacgttcggc caagggacca aggtggaaat caaacggact     420

gtggctgcac catctgtctt catcttcccg ccatctgatg agcagttgaa atctggaact     480

gcctctgttg tgtgcctgct gaataacttc tatcccagag aggccaaagt acagtggaag     540

gtggataacg ccctccaatc gggtaactcc caggagagtg tcacagagca ggacagcaag     600

gacagcacct acagcctcag cagcaccctg acgctgagca aagcagacta cgagaaacac     660

aaactctacg cctgcgaagt cacccatcag ggcctgagct cgcccgtcac aaagagcttc     720

aacaggggag agtgc                                                      735


<210> 74
<211> 1431
<212> DNA
<213> Artificial Sequence

<220> 
<223> IgG4 Hinge+ Ipilimumab heavy chain

<400> 74
gagtccaaat atggtccccc atgcccatca tgcccaggcg gccgcggcgg cggcggcagc      60

ggtcccctgg gtgtgagaag atctcaggtg cagctggtgg agtctggggg aggcgtggtc     120

cagcctggga ggtccctgag actctcctgt gcagcctctg gattcacctt cagtagctat     180

actatgcact gggtccgcca ggctccaggc aaggggctgg agtgggtgac atttatatca     240

tatgatggaa acaataaata ctacgcagac tccgtgaagg gccgattcac catctccaga     300

gacaattcca agaacacgct gtatctgcaa atgaacagcc tgagagctga ggacacggct     360

atatattact gtgcgaggac cggctggctg gggccctttg actactgggg ccagggaacc     420

ctggtcaccg tctcctcagc ctccaccaag ggaccatcgg tcttccccct ggcaccctcc     480

tccaagagca cctctggggg cacagcggcc ctgggctgcc tggtcaagga ctacttcccc     540

gaaccggtga cggtgtcgtg gaactcaggc gccctgacca gcggcgtgca caccttcccg     600

gctgtcctac agtcctcagg actctactcc ctcagcagcg tggtgaccgt gccctccagc     660

agcttgggca cccagaccta catctgcaac gtgaatcaca agcccagcaa caccaaggtc     720

gacaagaaag ttgagcccaa atcttgtgac aaaactcaca catgcccacc gtgcccagca     780

cccgaactcc tggggggacc gtcagtcttc ctcttccccc caaaacccaa ggacaccctc     840

atgatctccc ggacccctga ggtcacatgc gtggtggtgg acgtgagcca cgaagaccct     900

gaggtcaagt tcaactggta cgtggacggc gtggaggtgc ataatgccaa gacaaagccg     960

cgggaggagc agtacaacag cacgtaccgt gtggtcagcg tcctcaccgt cctgcaccag    1020

gactggctga atggcaagga gtacaagtgc aaggtctcca acaaagccct cccagccccc    1080

atcgagaaaa ccatctccaa agccaagggg cagccccgag aaccacaggt gtacaccctg    1140

cccccatccc gggatgagct gaccaagaac caggtcagcc tgacctgcct ggtcaaaggc    1200

ttctatccca gcgacatcgc cgtggagtgg gagagcaatg ggcagccgga gaacaactac    1260

aagaccacgc ctcccgtgct ggactccgac ggctccttct tcctctacag caagctcacc    1320

gtggacaaga gcaggtggca gcaggggaac gtcttctcat gctccgtgat gcatgaggct    1380

ctgcacaacc actacacgca gaagagcctc tccctgtctc cgggtaaata a             1431


<210> 75
<211> 768
<212> DNA
<213> Artificial Sequence

<220> 
<223> IgA1 Hinge+ Ipilimumab light chain

<400> 75
ccagttccct caactccacc taccccatct ccctcaactc cacctacccc atctccctca      60

tgctgccacg ttaacggcgg cggcggcagc ggtcccctgg gtgtgagagc ggcccagccg     120

gccgaaattg tgttgacgca gtctccaggc accctgtctt tgtctccagg ggaaagagcc     180

accctctcct gcagggccag tcagagtgtt ggcagcagct acttagcctg gtaccagcag     240

aaacctggcc aggctcccag gctcctcatc tatggtgcat tcagcagggc cactggcatc     300

ccagacaggt tcagtggcag tgggtctggg acagacttca ctctcaccat cagcagactg     360

gagcctgaag attttgcagt gtattactgt cagcagtatg gtagctcacc gtggacgttc     420

ggccaaggga ccaaggtgga aatcaaacgg actgtggctg caccatctgt cttcatcttc     480

ccgccatctg atgagcagtt gaaatctgga actgcctctg ttgtgtgcct gctgaataac     540

ttctatccca gagaggccaa agtacagtgg aaggtggata acgccctcca atcgggtaac     600

tcccaggaga gtgtcacaga gcaggacagc aaggacagca cctacagcct cagcagcacc     660

ctgacgctga gcaaagcaga ctacgagaaa cacaaactct acgcctgcga agtcacccat     720

cagggcctga gctcgcccgt cacaaagagc ttcaacaggg gagagtgc                  768


<210> 76
<211> 768
<212> DNA
<213> Artificial Sequence

<220> 
<223> IgA1 Hinge+ Ipilimumab heavy chain

<400> 76
ccagttccct caactccacc taccccatct ccctcaactc cacctacccc atctccctca      60

tgctgccacg ttaacggcgg cggcggcagc ggtcccctgg gtgtgagagc ggcccagccg     120

gccgaaattg tgttgacgca gtctccaggc accctgtctt tgtctccagg ggaaagagcc     180

accctctcct gcagggccag tcagagtgtt ggcagcagct acttagcctg gtaccagcag     240

aaacctggcc aggctcccag gctcctcatc tatggtgcat tcagcagggc cactggcatc     300

ccagacaggt tcagtggcag tgggtctggg acagacttca ctctcaccat cagcagactg     360

gagcctgaag attttgcagt gtattactgt cagcagtatg gtagctcacc gtggacgttc     420

ggccaaggga ccaaggtgga aatcaaacgg actgtggctg caccatctgt cttcatcttc     480

ccgccatctg atgagcagtt gaaatctgga actgcctctg ttgtgtgcct gctgaataac     540

ttctatccca gagaggccaa agtacagtgg aaggtggata acgccctcca atcgggtaac     600

tcccaggaga gtgtcacaga gcaggacagc aaggacagca cctacagcct cagcagcacc     660

ctgacgctga gcaaagcaga ctacgagaaa cacaaactct acgcctgcga agtcacccat     720

cagggcctga gctcgcccgt cacaaagagc ttcaacaggg gagagtgc                  768


<210> 77
<211> 729
<212> DNA
<213> Artificial Sequence

<220> 
<223> IgA2 Hinge+ Ipilimumab light chain

<400> 77
ccagttcccc cacctccccc atgctgccac gttaacggcg gcggcggcag cggtcccctg      60

ggtgtgagag cggcccagcc ggccgaaatt gtgttgacgc agtctccagg caccctgtct     120

ttgtctccag gggaaagagc caccctctcc tgcagggcca gtcagagtgt tggcagcagc     180

tacttagcct ggtaccagca gaaacctggc caggctccca ggctcctcat ctatggtgca     240

ttcagcaggg ccactggcat cccagacagg ttcagtggca gtgggtctgg gacagacttc     300

actctcacca tcagcagact ggagcctgaa gattttgcag tgtattactg tcagcagtat     360

ggtagctcac cgtggacgtt cggccaaggg accaaggtgg aaatcaaacg gactgtggct     420

gcaccatctg tcttcatctt cccgccatct gatgagcagt tgaaatctgg aactgcctct     480

gttgtgtgcc tgctgaataa cttctatccc agagaggcca aagtacagtg gaaggtggat     540

aacgccctcc aatcgggtaa ctcccaggag agtgtcacag agcaggacag caaggacagc     600

acctacagcc tcagcagcac cctgacgctg agcaaagcag actacgagaa acacaaactc     660

tacgcctgcg aagtcaccca tcagggcctg agctcgcccg tcacaaagag cttcaacagg     720

ggagagtgc                                                             729


<210> 78
<211> 729
<212> DNA
<213> Artificial Sequence

<220> 
<223> IgA2 Hinge+ Ipilimumab heavy chain

<400> 78
ccagttcccc cacctccccc atgctgccac gttaacggcg gcggcggcag cggtcccctg      60

ggtgtgagag cggcccagcc ggccgaaatt gtgttgacgc agtctccagg caccctgtct     120

ttgtctccag gggaaagagc caccctctcc tgcagggcca gtcagagtgt tggcagcagc     180

tacttagcct ggtaccagca gaaacctggc caggctccca ggctcctcat ctatggtgca     240

ttcagcaggg ccactggcat cccagacagg ttcagtggca gtgggtctgg gacagacttc     300

actctcacca tcagcagact ggagcctgaa gattttgcag tgtattactg tcagcagtat     360

ggtagctcac cgtggacgtt cggccaaggg accaaggtgg aaatcaaacg gactgtggct     420

gcaccatctg tcttcatctt cccgccatct gatgagcagt tgaaatctgg aactgcctct     480

gttgtgtgcc tgctgaataa cttctatccc agagaggcca aagtacagtg gaaggtggat     540

aacgccctcc aatcgggtaa ctcccaggag agtgtcacag agcaggacag caaggacagc     600

acctacagcc tcagcagcac cctgacgctg agcaaagcag actacgagaa acacaaactc     660

tacgcctgcg aagtcaccca tcagggcctg agctcgcccg tcacaaagag cttcaacagg     720

ggagagtgc                                                             729


