                         SEQUENCE LISTING

<110>  Casella, James
       Barron-Casella, Emily
       Keefer, Jeffrey
       Fortenberry, Yolanda
 
<120>  Development of Aptamers for the Treatment of Sickle Cell Anemia

<130>  111232-00272.P12386-02

<160>  65    

<170>  PatentIn version 3.5

<210>  1
<211>  80
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Synthetic Oligonucleotide Template, wherein n is a, c, g, or u


<220>
<221>  misc_feature
<222>  (16)..(55)
<223>  n is a, c, g, or u

<400>  1
gggaggacga ugcggnnnnn nnnnnnnnnn nnnnnnnnnn nnnnnnnnnn nnnnncagac       60

gacucgcuga ggauccgaga                                                   80


<210>  2
<211>  80
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Synthetic Aptamer

<400>  2
gggaggacga ugcggccgau uagaacuggg cugcgaucgg agauccucua gguuucagac       60

gacucgcuga ggauccgaga                                                   80


<210>  3
<211>  80
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Synthetic Aptamer

<400>  3
gggaggacga ugcgggccga gggauucggu guagacucug cacaguccug aaaagcagac       60

gacucgcuga ggauccgaga                                                   80


<210>  4
<211>  80
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Synthetic Aptamer

<400>  4
gggaggacga ugcggccgau uagaacuggg cugaggcguu cugcauuucg gugaucagac       60

gacucgcuga ggauccgaga                                                   80


<210>  5
<211>  80
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Synthetic Aptamer

<400>  5
gggaggacga ugcggccgau uagaacuggg cuguuccgac ucugaauccg gugaucagac       60

gacucgcuga ggauccgaga                                                   80


<210>  6
<211>  80
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Synthetic Aptamer

<400>  6
gggaggacga ugcgguuggu gaagggaggu cagcauaucu ucccgcggga agcgacggac       60

gacucgcuga ggauccgaga                                                   80


<210>  7
<211>  80
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Synthetic Aptamer

<400>  7
gggaggacga ugcggaucca cggguaaggg ugagggacga caucaaggcg agauucagac       60

gacucgcuga ggauccgaga                                                   80


<210>  8
<211>  80
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Synthetic Aptamer

<400>  8
gggaggacga ugcgguacga uuagaacugg ugccgaacag cgcucguuga agacacagac       60

gacucgcuga ggauccgaga                                                   80


<210>  9
<211>  80
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Synthetic Aptamer

<400>  9
gggaggacga ugcggaggaa guaggguucg uccauugggc gaguggccug uguuacagac       60

gacucgcuga ggauccgaga                                                   80


<210>  10
<211>  80
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Synthetic Aptamer

<400>  10
gggaggacga ugcggcacgg uauaguggag uggguaggca ucgcucgacg agugacagac       60

gacucgcuga ggauccgaga                                                   80


<210>  11
<211>  80
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Synthetic Aptamer

<400>  11
gggaggacga ugcgggagua gggagguaau cgccacccca acgcggagac agcgacagac       60

gacucgcuga ggauccgaga                                                   80


<210>  12
<211>  80
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Synthetic Aptamer

<400>  12
gggaggacga ugcggucgau agggggacgg accgcgcugg aaacucaacg uagcacagac       60

gacucgcuga ggauccgaga                                                   80


<210>  13
<211>  80
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Synthetic Aptamer

<400>  13
gggaggacga ugcggcacug augggagugg gaucaguguc gagcgguauc ugcagcagac       60

gacucgcuga ggauccgaga                                                   80


<210>  14
<211>  80
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Synthetic Aptamer

<400>  14
gggaggacga ugcgggagua gggagguaau cgucacccca acgcggagac agcgacagac       60

gacucgcuga ggauccgaga                                                   80


<210>  15
<211>  79
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Synthetic Aptamer

<400>  15
gggaggacga ugcggaagca uacaguuuag ugugcuaggg ugggacucag ugaucagacg       60

acucgcugag gauccgaga                                                    79


<210>  16
<211>  80
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Synthetic Aptamer

<400>  16
gggaggacga ugcgguccua cuuuccccaa uuuguaacag cucuccgcac agcagcagac       60

gacucgcuga ggauccgaga                                                   80


<210>  17
<211>  80
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Synthetic Aptamer

<400>  17
gggaggacga ugcggcggug uagggaucgu cagucucgga augaccucac agaagcagac       60

gacucgcuga ggauccgaga                                                   80


<210>  18
<211>  80
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Synthetic Aptamer

<400>  18
gggaggacga ugcggccagc aggaggaugg gugccgcacu cggauauuca cgugucagac       60

gacucgcuga ggauccgaga                                                   80


<210>  19
<211>  80
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Synthetic Aptamer

<400>  19
gggaggacga ugcgggacua agcacaacuc aacuagaacg aaccuauucc aucaucagac       60

gacucgcuga ggauccgaga                                                   80


<210>  20
<211>  80
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Synthetic Aptamer

<400>  20
gggaggacga ugcggaacgg aggagugucc ucucagcuga cagucgugca uacuacagac       60

gacucgcuga ggauccgaga                                                   80


<210>  21
<211>  80
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Synthetic Aptamer

<400>  21
gggaggacga ugcggaacuc gauccaucau cgugacugcg uacgugucaa cuaagcagac       60

gacucgcuga ggauccgaga                                                   80


<210>  22
<211>  80
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Synthetic Aptamer

<400>  22
gggaggacga ugcgggacgg ucauagagcc ggccgacauu agagccggga auccacagac       60

gacucgcuga ggauccgaga                                                   80


<210>  23
<211>  80
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Synthetic Aptamer

<400>  23
gggaggacga ugcgguggag aggggaaucg uccugcgcac ucugucuccu gagagcagac       60

gacucgcuga ggauccgaga                                                   80


<210>  24
<211>  80
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Synthetic Aptamer

<400>  24
gggaggacga ugcgguguau ccgccaguau gauuaacauc uauaaguccc uaugucagac       60

gacucgcuga ggauccgaga                                                   80


<210>  25
<211>  80
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Synthetic Aptamer

<400>  25
gggaggacga ugcggcuaac cuuguuaggg ccccauacag caucgaguga cggaucagac       60

gacucgcuga ggauccgaga                                                   80


<210>  26
<211>  80
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Synthetic Aptamer

<400>  26
gggaggacga ugcggugcac aggagguggu acacugcgcu cgauucauca gcgcacagac       60

gacucgcuga ggauccgaga                                                   80


<210>  27
<211>  80
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Synthetic Aptamer

<400>  27
gggaggacga ugcggcaugu gagggaggag guccgcguca uaaacuccag gaccacagac       60

gacucgcuga ggauccgaga                                                   80


<210>  28
<211>  80
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Synthetic Aptamer

<400>  28
gggaggacga ugcggaagca auagcucgcc guacaguugu ccugccguuc guguucagac       60

gacucgcuga ggauccgaga                                                   80


<210>  29
<211>  80
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Synthetic Aptamer

<400>  29
gggaggacga ugcgggagua gggagguaag cagcggacua acgagauucg gugagcagac       60

gacucgcuga ggauccgaga                                                   80


<210>  30
<211>  80
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Synthetic Aptamer

<400>  30
gggaggacga ugcggcgagc aaccggaacu cggcuauuau gaccagccaa cuuaacagac       60

gacucgcuga ggauccgaga                                                   80


<210>  31
<211>  80
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Synthetic Aptamer

<400>  31
gggaggacga ugcggcgagc aaccugaacu cggcuauuag gaccagccaa cuuaacagac       60

gacucgcuga ggauccgaga                                                   80


<210>  32
<211>  80
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Synthetic Aptamer

<400>  32
gggaggacga ugcgggaucg gaaccagcgu gacgaagcgc ggaucaacuc cggugcagac       60

gacucgcuga ggauccgaga                                                   80


<210>  33
<211>  80
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Synthetic Aptamer

<400>  33
gggaggacga ugcgggaucg gaaccagcgu gacgaagcgc ggaucaacuc cggugcugac       60

gacucgcuga ggauccgaga                                                   80


<210>  34
<211>  78
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Synthetic Aptamer

<400>  34
gggaggacga ugcggccgau uagaacuggg ucgcgcugua cccuagggau cgacagacga       60

cucgcugagg auccgaga                                                     78


<210>  35
<211>  80
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Synthetic Aptamer

<400>  35
gggaggacga ugcggagacc caagcgccac gucuggcaug ugagggagga gguaccagac       60

gacucgcuga ggauccgaga                                                   80


<210>  36
<211>  80
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Synthetic Aptamer

<400>  36
gggaggacga ugcggagagc caagcgccac gucuggcaug ugagggggga gguaccagac       60

gacucgcuga ggauccgaga                                                   80


<210>  37
<211>  80
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Synthetic Aptamer

<400>  37
gggaggacga ugcggaaacu caucgguagc cuuccugcgg ucagucuauu aggaccagac       60

gacucgcuga ggauccgaga                                                   80


<210>  38
<211>  80
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Synthetic Aptamer

<400>  38
gggaggacga ugcggcaauu accucagccu cccuagacac gucgucuauu aggaccagac       60

gacucgcuga ggauccgaga                                                   80


<210>  39
<211>  80
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Synthetic Aptamer

<400>  39
gggaggacga ugcggcaguc uuccgguaag cacggaggug aggggagcuu agcgucagac       60

gacucgcuga ggauccgaga                                                   80


<210>  40
<211>  80
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Synthetic Aptamer

<400>  40
gggaggacga ugcggauaug ccaugggucg cucgagugag gucgucuauu aggaccagac       60

gacucgcuga ggauccgaga                                                   80


<210>  41
<211>  80
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Synthetic Aptamer

<400>  41
gggaggacga ugcggagagc caagcgccac gucuggcaug ugagggagga gguaccagac       60

gacucgcuga ggauccgaga                                                   80


<210>  42
<211>  80
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Synthetic Aptamer

<400>  42
gggaggacga ugcggauugg cgcuauuagg accagcuccg uccgcaacug gucccgagac       60

gacucgcuga ggauccgaga                                                   80


<210>  43
<211>  80
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Synthetic Aptamer

<400>  43
gggaggacga ugcgggaaca gacccauggc aaucucgcga cgucuucggc cgcugcagac       60

gacucgcuga ggauccgaga                                                   80


<210>  44
<211>  79
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Synthetic Aptamer

<400>  44
gggaggacga ugcgguacaa cagguucaua cggcgcguug uuccuuggcu gacgcagacg       60

acucgcugag gauccgaga                                                    79


<210>  45
<211>  80
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Synthetic Aptamer

<400>  45
gggaggacga ugcggcacua uuaggaccag ugccuguugu cucgauaagc uccgccagac       60

gacucgcuga ggauccgaga                                                   80


<210>  46
<211>  80
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Synthetic Aptamer

<400>  46
gggaggacga ugcggauugg cgcuauuagg accagcuccg uccgcaacug aucccgagac       60

gacucgcuga ggauccgaga                                                   80


<210>  47
<211>  80
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Synthetic Aptamer

<400>  47
gggaggacga ugcggcuauu aggaccagcc guguagaauu cguagcgaug ugacgcagac       60

gacucgcuga ggauccgaga                                                   80


<210>  48
<211>  80
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Synthetic Aptamer

<400>  48
gggaggacga ugcgguucgc gcuauuagga ccagugcgaa cguggguaua caugucagac       60

gacucgcuga ggauccgaga                                                   80


<210>  49
<211>  80
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Synthetic Aptamer

<400>  49
gggaggacga ugcggaacac acgggacgag ccuggcgguu gucgucuauu aggaccagac       60

gacucgcuga ggauccgaga                                                   80


<210>  50
<211>  81
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Synthetic Aptamer

<400>  50
gggaggacga ugcgggucca ugcuuuaaac ugcaauuucc cguuuacacg ggcugucaga       60

cgacucgcug aggauccgag a                                                 81


<210>  51
<211>  80
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Synthetic Aptamer

<400>  51
gggaggacga ugcggaccac cgaaucacga ggugcgagac auugguuccc cgccgcagac       60

gacucgcuga ggauccgaga                                                   80


<210>  52
<211>  80
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Synthetic Aptamer

<400>  52
gggaggacga ugcgggggac aauaguccac gacuacaugu cggugcgucg gaggucagac       60

gacucgcuga ggauccgaga                                                   80


<210>  53
<211>  80
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Synthetic Aptamer

<400>  53
gggaggacga ugcggcuauu aggaccagcu gccaauguua agucuacccc agcagcagac       60

gacucgcuga ggauccgaga                                                   80


<210>  54
<211>  80
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Synthetic Aptamer

<400>  54
gggaggacga ugcggcuuac guauggucac ggaggugugg gggaacauac agcagcagac       60

gacucgcuga ggauccgaga                                                   80


<210>  55
<211>  80
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Synthetic Aptamer

<400>  55
gggaggacga ugcgguuggu gaccuauuca ggcguaggca uauaaacuac gaggccagac       60

gacucgcuga ggauccgaga                                                   80


<210>  56
<211>  80
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Synthetic Aptamer

<400>  56
gggaggacga ugcggcuauu aggaccagcu gccaauguua agucuacccc agcggcagac       60

gacucgcuga ggauccgaga                                                   80


<210>  57
<211>  80
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Synthetic Aptamer

<400>  57
gggaggacga ugcgggcacg acacgccgau uagaacuggg cgaucuuggu cgagccagac       60

gacucgcuga ggauccgaga                                                   80


<210>  58
<211>  80
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Synthetic Aptamer

<400>  58
gggaggacga ugcggcgaua cgaccgcaug aguauaccgu cgugcuuccc ggcugcagac       60

gacucgcuga ggauccgaga                                                   80


<210>  59
<211>  80
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Synthetic Aptamer

<400>  59
gggaggacga ugcggauugg cgcuauuagg accagcuccg uccgcaaccg guccccagac       60

gacucgcuga ggauccgaga                                                   80


<210>  60
<211>  80
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Synthetic Aptamer

<400>  60
gggaggacga ugcggauugg cgcuauuagg accagcuccg uccgcaacug guccccagac       60

gacucgcuga ggauccgaga                                                   80


<210>  61
<211>  11
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  RNA aptamer consensus sequence

<400>  61
gaacugggcu g                                                            11


<210>  62
<211>  15
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  RNA aptamer consensus sequence

<400>  62
caccccaacg cggag                                                        15


<210>  63
<211>  12
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  RNA aptamer consensus sequence

<400>  63
gucuauuagg ac                                                           12


<210>  64
<211>  13
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  RNA aptamer consensus sequence

<400>  64
cuauuaggac cag                                                          13


<210>  65
<211>  13
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  RNA aptamer consensus sequence

<400>  65
cgauuagaac ugg                                                          13


