                               SEQUENCE LISTING

<110> VYBION, INC.
 
<120> SINGLE CHAIN INTRABODIES THAT ALTER HUNTINGTIN MUTANT DEGRADATION

<130> 29262-26566/PCT

<140> PCT/US2014/037563
<141> 2014-05-09

<150> 61/871,288
<151> 2013-08-28

<150> 61/828,625
<151> 2013-05-29

<160> 40    

<170> PatentIn version 3.5

<210> 1
<211> 252
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      polypeptide

<400> 1
Met Ala Glu Val Gln Leu Val Val Ser Gly Gly Gly Leu Val Lys Pro 
1               5                   10                  15      


Gly Gly Ser Met Ile Leu Ser Cys Ala Ala Ser Gly Phe Thr Phe Ser 
            20                  25                  30          


Asn Tyr Ser Met Asn Trp Val Arg Gln Ala Pro Gly Lys Gly Leu Glu 
        35                  40                  45              


Trp Val Ser Ser Ile Ser Ser Ser Ser Glu Tyr Ile Tyr Tyr Ala Asp 
    50                  55                  60                  


Phe Val Lys Gly Arg Phe Thr Ile Ser Arg Asp Asn Ala Lys Asn Ser 
65                  70                  75                  80  


Leu Tyr Leu Gln Met Asp Ser Leu Arg Ala Glu Asp Thr Ala Val Tyr 
                85                  90                  95      


Tyr Cys Ala Trp Pro Gly Tyr Arg Lys Ala Trp Gly Arg Gly Thr Leu 
            100                 105                 110         


Val Thr Val Ser Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Gly 
        115                 120                 125             


Gly Gly Gly Ser Gln Ser Val Leu Thr Gln Pro Ala Ser Val Ser Gly 
    130                 135                 140                 


Ser Pro Gly Gln Ser Ile Thr Ile Ser Cys Ala Gly Thr Ser Ser Asp 
145                 150                 155                 160 


Val Gly Gly Tyr Asn Tyr Val Ser Trp Tyr Gln Gln His Pro Gly Lys 
                165                 170                 175     


Ala Pro Lys Leu Met Ile Tyr Glu Asp Ser Lys Arg Pro Ser Gly Val 
            180                 185                 190         


Ser Asn Arg Phe Ser Gly Ser Lys Ser Gly Asn Thr Ala Ser Leu Thr 
        195                 200                 205             


Ile Ser Gly Leu Arg Ala Glu Asp Glu Ala Asp Tyr Tyr Cys Ser Tyr 
    210                 215                 220                 


Cys Ala Ser Lys Gly His Trp Leu Phe Gly Gly Gly Thr Lys Leu Ala 
225                 230                 235                 240 


Val Leu Gly Ala Ala Ala Glu Gln Lys Leu Ile Ser 
                245                 250         


<210> 2
<211> 253
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      polypeptide

<400> 2
Met Ala Glu Val Gln Leu Val Val Ser Gly Gly Gly Leu Val Lys Pro 
1               5                   10                  15      


Gly Gly Ser Met Ile Leu Ser Cys Ala Ala Ser Gly Phe Thr Phe Ser 
            20                  25                  30          


Asn Tyr Ser Met Asn Trp Val Arg Gln Ala Pro Gly Lys Gly Leu Glu 
        35                  40                  45              


Trp Val Ser Ser Ile Ser Ser Ser Ser Glu Tyr Ile Tyr Tyr Ala Asp 
    50                  55                  60                  


Phe Val Lys Gly Arg Phe Thr Ile Ser Arg Asp Asn Ala Lys Asn Ser 
65                  70                  75                  80  


Leu Tyr Leu Gln Met Asp Ser Leu Arg Ala Glu Asp Thr Ala Val Tyr 
                85                  90                  95      


Tyr Cys Ala His Trp Pro Arg Leu Trp Arg Phe Pro Leu Trp Gly Arg 
            100                 105                 110         


Gly Thr Leu Val Thr Val Ser Ser Gly Gly Gly Gly Ser Gly Gly Gly 
        115                 120                 125             


Gly Ser Gly Gly Gly Gly Ser Gln Ser Val Leu Thr Gln Pro Ala Ser 
    130                 135                 140                 


Val Ser Gly Ser Pro Gly Gln Ser Ile Thr Ile Ser Cys Ala Gly Thr 
145                 150                 155                 160 


Ser Ser Asp Val Gly Gly Tyr Asn Tyr Val Ser Trp Tyr Gln Gln His 
                165                 170                 175     


Pro Gly Lys Ala Pro Lys Leu Met Ile Tyr Glu Asp Ser Lys Arg Pro 
            180                 185                 190         


Ser Gly Val Ser Asn Arg Phe Ser Gly Ser Lys Ser Gly Asn Thr Ala 
        195                 200                 205             


Ser Leu Thr Ile Ser Gly Leu Arg Ala Glu Asp Glu Ala Asp Tyr Tyr 
    210                 215                 220                 


Cys Val Leu Asn Met His Trp Ala Asn Phe Gly Gly Gly Thr Lys Leu 
225                 230                 235                 240 


Ala Val Leu Gly Ala Ala Ala Glu Gln Lys Leu Ile Ser 
                245                 250             


<210> 3
<211> 252
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      polypeptide

<400> 3
Met Ala Glu Val Gln Leu Val Val Ser Gly Gly Gly Leu Val Lys Pro 
1               5                   10                  15      


Gly Gly Ser Met Ile Leu Ser Cys Ala Ala Ser Gly Phe Thr Phe Ser 
            20                  25                  30          


Asn Tyr Ser Met Asn Trp Val Arg Gln Ala Pro Gly Lys Gly Leu Glu 
        35                  40                  45              


Trp Val Ser Ser Ile Ser Ser Ser Ser Glu Tyr Ile Tyr Tyr Ala Asp 
    50                  55                  60                  


Phe Val Lys Gly Arg Phe Thr Ile Ser Arg Asp Asn Ala Lys Asn Ser 
65                  70                  75                  80  


Leu Tyr Leu Gln Met Asp Ser Leu Arg Ala Glu Asp Thr Ala Val Tyr 
                85                  90                  95      


Tyr Cys Ala Ile Thr Gly Cys Glu Cys Thr Trp Gly Arg Gly Thr Leu 
            100                 105                 110         


Val Thr Val Ser Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Gly 
        115                 120                 125             


Gly Gly Gly Ser Gln Ser Val Leu Thr Gln Pro Ala Ser Val Ser Gly 
    130                 135                 140                 


Ser Pro Gly Gln Ser Ile Thr Ile Ser Cys Ala Gly Thr Ser Ser Asp 
145                 150                 155                 160 


Val Gly Gly Tyr Asn Tyr Val Ser Trp Tyr Gln Gln His Pro Gly Lys 
                165                 170                 175     


Ala Pro Lys Leu Met Ile Tyr Glu Asp Ser Lys Arg Pro Ser Gly Val 
            180                 185                 190         


Ser Asn Arg Phe Ser Gly Ser Lys Ser Gly Asn Thr Ala Ser Leu Thr 
        195                 200                 205             


Ile Ser Gly Leu Arg Ala Glu Asp Glu Ala Asp Tyr Tyr Cys Ser Cys 
    210                 215                 220                 


Ile Arg Gly Leu Lys Ala Ala Tyr Phe Gly Gly Gly Thr Lys Leu Ala 
225                 230                 235                 240 


Val Leu Gly Ala Ala Ala Glu Gln Lys Leu Ile Ser 
                245                 250         


<210> 4
<211> 253
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      polypeptide

<400> 4
Met Ala Glu Val Gln Leu Val Val Ser Gly Gly Gly Leu Val Lys Pro 
1               5                   10                  15      


Gly Gly Ser Met Ile Leu Ser Cys Ala Ala Ser Gly Phe Thr Phe Ser 
            20                  25                  30          


Asn Tyr Ser Met Asn Trp Val Arg Gln Ala Pro Gly Lys Gly Leu Glu 
        35                  40                  45              


Trp Val Ser Ser Ile Ser Ser Ser Ser Glu Tyr Ile Tyr Tyr Ala Asp 
    50                  55                  60                  


Phe Val Lys Gly Arg Phe Thr Ile Ser Arg Asp Asn Ala Lys Asn Ser 
65                  70                  75                  80  


Leu Tyr Leu Gln Met Asp Ser Leu Arg Ala Glu Asp Thr Ala Val Tyr 
                85                  90                  95      


Tyr Cys Ala Ala Ala Val Cys Asn Gly Arg Pro Asp Thr Trp Gly Arg 
            100                 105                 110         


Gly Thr Leu Val Thr Val Ser Ser Gly Gly Gly Gly Ser Gly Gly Gly 
        115                 120                 125             


Gly Ser Gly Gly Gly Gly Ser Gln Ser Val Leu Thr Gln Pro Ala Ser 
    130                 135                 140                 


Val Ser Gly Ser Pro Gly Gln Ser Ile Thr Ile Ser Cys Ala Gly Thr 
145                 150                 155                 160 


Ser Ser Asp Val Gly Gly Tyr Asn Tyr Val Ser Trp Tyr Gln Gln His 
                165                 170                 175     


Pro Gly Lys Ala Pro Lys Leu Met Ile Tyr Glu Asp Ser Lys Arg Pro 
            180                 185                 190         


Ser Gly Val Ser Asn Arg Phe Ser Gly Ser Lys Ser Gly Asn Thr Ala 
        195                 200                 205             


Ser Leu Thr Ile Ser Gly Leu Arg Ala Glu Asp Glu Ala Asp Tyr Tyr 
    210                 215                 220                 


Cys Gly Tyr Ser Leu Leu Pro Val Leu Phe Gly Gly Gly Thr Lys Leu 
225                 230                 235                 240 


Ala Val Leu Gly Ala Ala Ala Glu Gln Lys Leu Ile Ser 
                245                 250             


<210> 5
<211> 254
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      polypeptide


<220>
<221> MOD_RES
<222> (100)..(100)
<223> His, Ile, Ala or not present

<220>
<221> MOD_RES
<222> (104)..(104)
<223> Leu, Tyr, Glu or Asn

<220>
<221> MOD_RES
<222> (105)..(105)
<223> Trp, Arg, Cys or Gly

<220>
<221> MOD_RES
<222> (106)..(106)
<223> May or may not be present

<220>
<221> MOD_RES
<222> (107)..(107)
<223> Pro, Lys, Asp or not present

<220>
<221> MOD_RES
<222> (226)..(226)
<223> May or may not be present

<220>
<221> MOD_RES
<222> (227)..(227)
<223> Val, Ala, Ile or not present

<220>
<221> MOD_RES
<222> (228)..(228)
<223> Leu, Ser, Arg or Tyr

<220>
<221> MOD_RES
<222> (229)..(229)
<223> Asn, Lys, Gly or Ser

<220>
<221> MOD_RES
<222> (234)..(234)
<223> Asn, Tyr, Leu or not present

<400> 5
Met Ala Glu Val Gln Leu Val Val Ser Gly Gly Gly Leu Val Lys Pro 
1               5                   10                  15      


Gly Gly Ser Met Ile Leu Ser Cys Ala Ala Ser Gly Phe Thr Phe Ser 
            20                  25                  30          


Asn Tyr Ser Met Asn Trp Val Arg Gln Ala Pro Gly Lys Gly Leu Glu 
        35                  40                  45              


Trp Val Ser Ser Ile Ser Ser Ser Ser Glu Tyr Ile Tyr Tyr Ala Asp 
    50                  55                  60                  


Phe Val Lys Gly Arg Phe Thr Ile Ser Arg Asp Asn Ala Lys Asn Ser 
65                  70                  75                  80  


Leu Tyr Leu Gln Met Asp Ser Leu Arg Ala Glu Asp Thr Ala Val Tyr 
                85                  90                  95      


Tyr Cys Ala Xaa Trp Pro Cys Xaa Xaa Arg Xaa Thr Trp Gly Arg Gly 
            100                 105                 110         


Thr Leu Val Thr Val Ser Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly 
        115                 120                 125             


Ser Gly Gly Gly Gly Ser Gln Ser Val Leu Thr Gln Pro Ala Ser Val 
    130                 135                 140                 


Ser Gly Ser Pro Gly Gln Ser Ile Thr Ile Ser Cys Lys Asn Ser Ser 
145                 150                 155                 160 


Ser Asp Val Gly Gly Tyr Asn Tyr Val Ser Trp Tyr Gln Gln His Pro 
                165                 170                 175     


Gly Lys Ala Pro Lys Leu Met Ile Tyr Glu Asp Ser Lys Arg Pro Ser 
            180                 185                 190         


Gly Val Ser Asn Arg Phe Ser Gly Ser Lys Ser Gly Asn Thr Ala Ser 
        195                 200                 205             


Leu Thr Ile Ser Gly Leu Arg Ala Glu Asp Glu Ala Asp Tyr Tyr Cys 
    210                 215                 220                 


Ser Cys Xaa Xaa Xaa Leu His Trp Ala Xaa Phe Gly Gly Gly Thr Lys 
225                 230                 235                 240 


Leu Ala Val Leu Gly Ala Ala Ala Glu Gln Lys Leu Ile Ser 
                245                 250                 


<210> 6
<211> 7
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      peptide

<400> 6
Trp Pro Gly Tyr Arg Lys Ala 
1               5           


<210> 7
<211> 10
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      peptide

<400> 7
His Trp Pro Arg Leu Trp Arg Phe Pro Leu 
1               5                   10  


<210> 8
<211> 7
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      peptide

<400> 8
Ile Thr Gly Cys Glu Cys Thr 
1               5           


<210> 9
<211> 10
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      peptide

<400> 9
Ala Ala Val Cys Asn Gly Arg Pro Asp Thr 
1               5                   10  


<210> 10
<211> 10
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      peptide

<400> 10
Ser Tyr Cys Ala Ser Lys Gly His Trp Leu 
1               5                   10  


<210> 11
<211> 8
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      peptide

<400> 11
Val Leu Asn Met His Trp Ala Asn 
1               5               


<210> 12
<211> 10
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      peptide

<400> 12
Ser Cys Ile Arg Gly Leu Lys Ala Ala Tyr 
1               5                   10  


<210> 13
<211> 8
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      peptide

<400> 13
Gly Tyr Ser Leu Leu Pro Val Leu 
1               5               


<210> 14
<211> 9
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      peptide


<220>
<221> MOD_RES
<222> (1)..(1)
<223> His, Ile, Ala or not present

<220>
<221> MOD_RES
<222> (5)..(5)
<223> Leu, Tyr, Glu or Asn

<220>
<221> MOD_RES
<222> (6)..(6)
<223> Trp, Arg, Cys or Gly

<220>
<221> MOD_RES
<222> (7)..(7)
<223> May or may not be present

<220>
<221> MOD_RES
<222> (8)..(8)
<223> Pro, Lys or Asp 

<400> 14
Xaa Trp Pro Cys Xaa Xaa Arg Xaa Thr 
1               5                   


<210> 15
<211> 10
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      peptide


<220>
<221> MOD_RES
<222> (2)..(2)
<223> May or may not be present

<220>
<221> MOD_RES
<222> (3)..(3)
<223> Val, Ala, Ile or not present

<220>
<221> MOD_RES
<222> (4)..(4)
<223> Leu, Ser, Arg or Tyr

<220>
<221> MOD_RES
<222> (5)..(5)
<223> Asn, Lys, Gly or Ser

<220>
<221> MOD_RES
<222> (10)..(10)
<223> Leu, Ala or Thr

<400> 15
Ser Cys Xaa Xaa Xaa Leu His Trp Ala Xaa 
1               5                   10  


<210> 16
<211> 17
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      peptide

<400> 16
Ser Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly 
1               5                   10                  15      


Ser 
    


<210> 17
<211> 12
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      peptide

<400> 17
Pro Gln Leu Pro Gln Pro Pro Pro Gln Ala Gln Pro 
1               5                   10          


<210> 18
<211> 13
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      peptide

<400> 18
Pro Gly Pro Ala Val Ala Glu Glu Pro Leu His Arg Pro 
1               5                   10              


<210> 19
<211> 60
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      primer

<400> 19
gaccatgatt acgccaagct tggctagcca tatgtctaga atggcagaag ttcagctggt       60


<210> 20
<211> 60
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      primer

<400> 20
atccagtgat ttttttctcg tcgacctcga gtgcggccgc acccagaact gccagtttgg       60


<210> 21
<211> 5
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      peptide

<400> 21
Val Ser Gly Gly Gly 
1               5   


<210> 22
<211> 9
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      peptide

<400> 22
Val Ser Ser Ile Ser Ser Ser Ser Glu 
1               5                   


<210> 23
<211> 10
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      peptide

<400> 23
Ala Gly Thr Ser Ser Asp Val Gly Gly Tyr 
1               5                   10  


<210> 24
<211> 6
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      peptide

<400> 24
Ile Tyr Glu Asp Ser Lys 
1               5       


<210> 25
<211> 19
<212> PRT
<213> Homo sapiens

<400> 25
Arg Pro Gln Leu Pro Gln Pro Pro Pro Gln Ala Gln Pro Arg Gly Gly 
1               5                   10                  15      


Gly Ser Lys 
            


<210> 26
<211> 19
<212> PRT
<213> Homo sapiens


<220>
<221> misc_feature
<222> (1)..(19)
<223> C-term biotin

<400> 26
Arg Pro Gln Leu Pro Gln Pro Pro Pro Gln Ala Gln Pro Arg Gly Gly 
1               5                   10                  15      


Gly Ser Lys 
            


<210> 27
<211> 14
<212> PRT
<213> Homo sapiens

<400> 27
Pro Gly Pro Ala Val Ala Glu Glu Pro Leu His Arg Pro Gly 
1               5                   10                  


<210> 28
<211> 14
<212> PRT
<213> Homo sapiens


<220>
<221> misc_feature
<222> (1)..(14)
<223> C-term biotin

<400> 28
Pro Gly Pro Ala Val Ala Glu Glu Pro Leu His Arg Pro Gly 
1               5                   10                  


<210> 29
<211> 22
<212> PRT
<213> Homo sapiens

<400> 29
Met Ala Thr Leu Glu Lys Leu Met Lys Ala Phe Glu Ser Leu Lys Ser 
1               5                   10                  15      


Phe Gln Gln Gln Gln Gln 
            20          


<210> 30
<211> 28
<212> PRT
<213> Homo sapiens

<400> 30
Pro Pro Pro Pro Pro Pro Pro Pro Pro Pro Pro Gln Leu Pro Gln Pro 
1               5                   10                  15      


Pro Pro Gln Ala Gln Pro Leu Leu Pro Gln Pro Gln 
            20                  25              


<210> 31
<211> 23
<212> PRT
<213> Homo sapiens

<400> 31
Pro Pro Pro Pro Pro Pro Pro Pro Pro Pro Gly Pro Ala Val Ala Glu 
1               5                   10                  15      


Glu Pro Leu His Arg Pro Lys 
            20              


<210> 32
<211> 38
<212> PRT
<213> Homo sapiens

<400> 32
Gln Gln Gln Gln Gln Gln Gln Gln Gln Gln Gln Gln Gln Gln Gln Gln 
1               5                   10                  15      


Gln Gln Gln Gln Gln Gln Gln Gln Gln Gln Gln Gln Gln Gln Gln Gln 
            20                  25                  30          


Gln Gln Gln Gln Gln Gln 
        35              


<210> 33
<211> 30
<212> PRT
<213> Homo sapiens

<400> 33
Gln Gln Gln Gln Gln Gln Gln Gln Gln Gln Gln Gln Gln Gln Gln Gln 
1               5                   10                  15      


Gln Gln Gln Gln Gln Gln Gln Gln Gln Gln Gln Gln Gln Gln 
            20                  25                  30  


<210> 34
<211> 103
<212> PRT
<213> Homo sapiens

<400> 34
Gln Gln Gln Gln Gln Gln Gln Gln Gln Gln Gln Gln Gln Gln Gln Gln 
1               5                   10                  15      


Gln Gln Gln Gln Gln Gln Gln Gln Gln Gln Gln Gln Gln Gln Gln Gln 
            20                  25                  30          


Gln Gln Gln Gln Gln Gln Gln Gln Gln Gln Gln Gln Gln Gln Gln Gln 
        35                  40                  45              


Gln Gln Gln Gln Gln Gln Gln Gln Gln Gln Gln Gln Gln Gln Gln Gln 
    50                  55                  60                  


Gln Gln Gln Gln Gln Gln Gln Gln Gln Gln Gln Gln Gln Gln Gln Gln 
65                  70                  75                  80  


Gln Gln Gln Gln Gln Gln Gln Gln Gln Gln Gln Gln Gln Gln Gln Gln 
                85                  90                  95      


Gln Gln Gln Gln Gln Gln Gln 
            100             


<210> 35
<211> 73
<212> PRT
<213> Homo sapiens

<400> 35
Gln Gln Gln Gln Gln Gln Gln Gln Gln Gln Gln Gln Gln Gln Gln Gln 
1               5                   10                  15      


Gln Gln Gln Gln Gln Gln Gln Gln Gln Gln Gln Gln Gln Gln Gln Gln 
            20                  25                  30          


Gln Gln Gln Gln Gln Gln Gln Gln Gln Gln Gln Gln Gln Gln Gln Gln 
        35                  40                  45              


Gln Gln Gln Gln Gln Gln Gln Gln Gln Gln Gln Gln Gln Gln Gln Gln 
    50                  55                  60                  


Gln Gln Gln Gln Gln Gln Gln Gln Gln 
65                  70              


<210> 36
<211> 150
<212> PRT
<213> Homo sapiens

<400> 36
Gln Gln Gln Gln Gln Gln Gln Gln Gln Gln Gln Gln Gln Gln Gln Gln 
1               5                   10                  15      


Gln Gln Gln Gln Gln Gln Gln Gln Gln Gln Gln Gln Gln Gln Gln Gln 
            20                  25                  30          


Gln Gln Gln Gln Gln Gln Gln Gln Gln Gln Gln Gln Gln Gln Gln Gln 
        35                  40                  45              


Gln Gln Gln Gln Gln Gln Gln Gln Gln Gln Gln Gln Gln Gln Gln Gln 
    50                  55                  60                  


Gln Gln Gln Gln Gln Gln Gln Gln Gln Gln Gln Gln Gln Gln Gln Gln 
65                  70                  75                  80  


Gln Gln Gln Gln Gln Gln Gln Gln Gln Gln Gln Gln Gln Gln Gln Gln 
                85                  90                  95      


Gln Gln Gln Gln Gln Gln Gln Gln Gln Gln Gln Gln Gln Gln Gln Gln 
            100                 105                 110         


Gln Gln Gln Gln Gln Gln Gln Gln Gln Gln Gln Gln Gln Gln Gln Gln 
        115                 120                 125             


Gln Gln Gln Gln Gln Gln Gln Gln Gln Gln Gln Gln Gln Gln Gln Gln 
    130                 135                 140                 


Gln Gln Gln Gln Gln Gln 
145                 150 


<210> 37
<211> 120
<212> PRT
<213> Mus sp.

<400> 37
Gln Gln Gln Gln Gln Gln Gln Gln Gln Gln Gln Gln Gln Gln Gln Gln 
1               5                   10                  15      


Gln Gln Gln Gln Gln Gln Gln Gln Gln Gln Gln Gln Gln Gln Gln Gln 
            20                  25                  30          


Gln Gln Gln Gln Gln Gln Gln Gln Gln Gln Gln Gln Gln Gln Gln Gln 
        35                  40                  45              


Gln Gln Gln Gln Gln Gln Gln Gln Gln Gln Gln Gln Gln Gln Gln Gln 
    50                  55                  60                  


Gln Gln Gln Gln Gln Gln Gln Gln Gln Gln Gln Gln Gln Gln Gln Gln 
65                  70                  75                  80  


Gln Gln Gln Gln Gln Gln Gln Gln Gln Gln Gln Gln Gln Gln Gln Gln 
                85                  90                  95      


Gln Gln Gln Gln Gln Gln Gln Gln Gln Gln Gln Gln Gln Gln Gln Gln 
            100                 105                 110         


Gln Gln Gln Gln Gln Gln Gln Gln 
        115                 120 


<210> 38
<211> 6
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      6xHis tag

<400> 38
His His His His His His 
1               5       


<210> 39
<211> 23
<212> PRT
<213> Homo sapiens

<400> 39
Gln Gln Gln Gln Gln Gln Gln Gln Gln Gln Gln Gln Gln Gln Gln Gln 
1               5                   10                  15      


Gln Gln Gln Gln Gln Gln Gln 
            20                 


<210> 40
<211> 758
<212> PRT
<213> Homo sapiens

<400> 40
Met Ala Glu Pro Arg Gln Glu Phe Glu Val Met Glu Asp His Ala Gly 
1               5                   10                  15      


Thr Tyr Gly Leu Gly Asp Arg Lys Asp Gln Gly Gly Tyr Thr Met His 
            20                  25                  30          


Gln Asp Gln Glu Gly Asp Thr Asp Ala Gly Leu Lys Glu Ser Pro Leu 
        35                  40                  45              


Gln Thr Pro Thr Glu Asp Gly Ser Glu Glu Pro Gly Ser Glu Thr Ser 
    50                  55                  60                  


Asp Ala Lys Ser Thr Pro Thr Ala Glu Asp Val Thr Ala Pro Leu Val 
65                  70                  75                  80  


Asp Glu Gly Ala Pro Gly Lys Gln Ala Ala Ala Gln Pro His Thr Glu 
                85                  90                  95      


Ile Pro Glu Gly Thr Thr Ala Glu Glu Ala Gly Ile Gly Asp Thr Pro 
            100                 105                 110         


Ser Leu Glu Asp Glu Ala Ala Gly His Val Thr Gln Glu Pro Glu Ser 
        115                 120                 125             


Gly Lys Val Val Gln Glu Gly Phe Leu Arg Glu Pro Gly Pro Pro Gly 
    130                 135                 140                 


Leu Ser His Gln Leu Met Ser Gly Met Pro Gly Ala Pro Leu Leu Pro 
145                 150                 155                 160 


Glu Gly Pro Arg Glu Ala Thr Arg Gln Pro Ser Gly Thr Gly Pro Glu 
                165                 170                 175     


Asp Thr Glu Gly Gly Arg His Ala Pro Glu Leu Leu Lys His Gln Leu 
            180                 185                 190         


Leu Gly Asp Leu His Gln Glu Gly Pro Pro Leu Lys Gly Ala Gly Gly 
        195                 200                 205             


Lys Glu Arg Pro Gly Ser Lys Glu Glu Val Asp Glu Asp Arg Asp Val 
    210                 215                 220                 


Asp Glu Ser Ser Pro Gln Asp Ser Pro Pro Ser Lys Ala Ser Pro Ala 
225                 230                 235                 240 


Gln Asp Gly Arg Pro Pro Gln Thr Ala Ala Arg Glu Ala Thr Ser Ile 
                245                 250                 255     


Pro Gly Phe Pro Ala Glu Gly Ala Ile Pro Leu Pro Val Asp Phe Leu 
            260                 265                 270         


Ser Lys Val Ser Thr Glu Ile Pro Ala Ser Glu Pro Asp Gly Pro Ser 
        275                 280                 285             


Val Gly Arg Ala Lys Gly Gln Asp Ala Pro Leu Glu Phe Thr Phe His 
    290                 295                 300                 


Val Glu Ile Thr Pro Asn Val Gln Lys Glu Gln Ala His Ser Glu Glu 
305                 310                 315                 320 


His Leu Gly Arg Ala Ala Phe Pro Gly Ala Pro Gly Glu Gly Pro Glu 
                325                 330                 335     


Ala Arg Gly Pro Ser Leu Gly Glu Asp Thr Lys Glu Ala Asp Leu Pro 
            340                 345                 350         


Glu Pro Ser Glu Lys Gln Pro Ala Ala Ala Pro Arg Gly Lys Pro Val 
        355                 360                 365             


Ser Arg Val Pro Gln Leu Lys Ala Arg Met Val Ser Lys Ser Lys Asp 
    370                 375                 380                 


Gly Thr Gly Ser Asp Asp Lys Lys Ala Lys Thr Ser Thr Arg Ser Ser 
385                 390                 395                 400 


Ala Lys Thr Leu Lys Asn Arg Pro Cys Leu Ser Pro Lys His Pro Thr 
                405                 410                 415     


Pro Gly Ser Ser Asp Pro Leu Ile Gln Pro Ser Ser Pro Ala Val Cys 
            420                 425                 430         


Pro Glu Pro Pro Ser Ser Pro Lys Tyr Val Ser Ser Val Thr Ser Arg 
        435                 440                 445             


Thr Gly Ser Ser Gly Ala Lys Glu Met Lys Leu Lys Gly Ala Asp Gly 
    450                 455                 460                 


Lys Thr Lys Ile Ala Thr Pro Arg Gly Ala Ala Pro Pro Gly Gln Lys 
465                 470                 475                 480 


Gly Gln Ala Asn Ala Thr Arg Ile Pro Ala Lys Thr Pro Pro Ala Pro 
                485                 490                 495     


Lys Thr Pro Pro Ser Ser Gly Glu Pro Pro Lys Ser Gly Asp Arg Ser 
            500                 505                 510         


Gly Tyr Ser Ser Pro Gly Ser Pro Gly Thr Pro Gly Ser Arg Ser Arg 
        515                 520                 525             


Thr Pro Ser Leu Pro Thr Pro Pro Thr Arg Glu Pro Lys Lys Val Ala 
    530                 535                 540                 


Val Val Arg Thr Pro Pro Lys Ser Pro Ser Ser Ala Lys Ser Arg Leu 
545                 550                 555                 560 


Gln Thr Ala Pro Val Pro Met Pro Asp Leu Lys Asn Val Lys Ser Lys 
                565                 570                 575     


Ile Gly Ser Thr Glu Asn Leu Lys His Gln Pro Gly Gly Gly Lys Val 
            580                 585                 590         


Gln Ile Ile Asn Lys Lys Leu Asp Leu Ser Asn Val Gln Ser Lys Cys 
        595                 600                 605             


Gly Ser Lys Asp Asn Ile Lys His Val Pro Gly Gly Gly Ser Val Gln 
    610                 615                 620                 


Ile Val Tyr Lys Pro Val Asp Leu Ser Lys Val Thr Ser Lys Cys Gly 
625                 630                 635                 640 


Ser Leu Gly Asn Ile His His Lys Pro Gly Gly Gly Gln Val Glu Val 
                645                 650                 655     


Lys Ser Glu Lys Leu Asp Phe Lys Asp Arg Val Gln Ser Lys Ile Gly 
            660                 665                 670         


Ser Leu Asp Asn Ile Thr His Val Pro Gly Gly Gly Asn Lys Lys Ile 
        675                 680                 685             


Glu Thr His Lys Leu Thr Phe Arg Glu Asn Ala Lys Ala Lys Thr Asp 
    690                 695                 700                 


His Gly Ala Glu Ile Val Tyr Lys Ser Pro Val Val Ser Gly Asp Thr 
705                 710                 715                 720 


Ser Pro Arg His Leu Ser Asn Val Ser Ser Thr Gly Ser Ile Asp Met 
                725                 730                 735     


Val Asp Ser Pro Gln Leu Ala Thr Leu Ala Asp Glu Val Ser Ala Ser 
            740                 745                 750         


Leu Ala Lys Gln Gly Leu 
        755             


