                         SEQUENCE LISTING

<110>  Oklahoma Medical Research Foundation
 
<120>  BRIGHT/ARID3A FUNCTION/EXPRESSION AS A MARKER FOR SYSTEMIC LUPUS 
       ERYTHEMATOSUS SEVERITY AND INTENSITY

<130>  OMRF.P0115WO

<140>  Unknown
<141>  2014-05-06

<150>  US 61/828,473
<151>  2013-05-29

<160>  46    

<170>  PatentIn version 3.5

<210>  1
<211>  1782
<212>  DNA
<213>  Homo sapiens

<400>  1
atgaaactac aggccgtgat ggagacgctg ttgcagcggc agcagcgggc gcgccaggag       60

ctggaggccc ggcagcagct gccccccgat ccccctgctg caccccccgg ccgggcccgg      120

gctgcccccg acgaggacag agagcccgag agtgcccgga tgcagcgggc tcagatggcc      180

gcactggcag ccatgcgggc tgcagctgcg ggcctgggac acccagccag ccccggcggc      240

tctgaggatg ggcccccagg ctcggaggag gaggacgcgg cccgggaggg gacaccgggc      300

tcacccgggc gaggcagaga agggccagga gaggagcact ttgaggacat ggcctccgac      360

gaggacatga agcccaaatg ggaggaggag gagatggagg aagacctcgg ggaggatgag      420

gaggaggagg aggaggatta cgaggatgag gaggaggagg aggacgagga ggggctgggc      480

cccccaggcc ctgccagctt gggcaccacg gcactgttcc cccgaaaggc ccagccaccc      540

caggccttcc gcggcgatgg cgttcccagg gtgctggggg gccaggagcg gccggggcct      600

ggccctgccc accccggagg ggccgcccac gtagccccgc agctgcagcc gcctgaccac      660

ggcgactgga cttacgagga gcagtttaag cagctctacg aactcgacgg ggaccccaag      720

aggaaggaat tcctggatga cttgttcagc ttcatgcaga agcgagggac acctgtgaac      780

cgcatcccca tcatggccaa acaggtcctt gacctgttca tgctgtacgt gctggtgacg      840

gagaagggcg gcctcgtgga ggtcatcaac aagaagctgt ggcgtgagat caccaagggc      900

ctcaacctgc ccacgtccat caccagtgca gccttcaccc tgcggaccca atacatgaag      960

tacctgtacc cctacgagtg tgagaagcgg ggcctcagta accccaatga gctccaggca     1020

gccatagaca gcaaccgacg ggagggccgg cgccagagct ttggtggctc cctctttgcc     1080

tactcgccag gcggggcaca cggcatgctc tcctcaccca agctacccgt gtcctccctg     1140

ggcctggccg caagcaccaa tggcagctcc atcacccccg cccctaagat caagaaagag     1200

gaggactcag ccatccccat cacagtccct ggccgcctgc ctgtgtccct ggcgggccac     1260

cctgtggtgg cagcccaggc agcagctgtg caagcagcag ccgcccaagc agctgtggcc     1320

gcacaggcag ctgccctgga acagctgcgg gagaagctgg agtctgcaga gcctccggag     1380

aagaagatgg ccctggtggc cgatgagcag caacggctga tgcaacgtgc actccagcag     1440

aacttcctgg ccatggcggc ccagctgccc atgagcattc ggatcaacag ccaagcctcc     1500

gaaagccgcc aggactctgc tgtgaacctg acgggcacca acggcagcaa cagcatcagc     1560

atgtcggtgg agatcaacgg catcatgtac acaggagttc tgtttgctca gccgccggcc     1620

cccacgccaa cctctgctcc caacaaagga ggcggcggcg gcggcggcag cagcagcaac     1680

gcaggcggcc ggggaggaaa caccggaacc agcggcggcc aggctgggcc agcggggctg     1740

tccacaccct ccacatctac ctcaaataac tcgttgcctt aa                        1782


<210>  2
<211>  593
<212>  PRT
<213>  Homo sapiens

<400>  2

Met Lys Leu Gln Ala Val Met Glu Thr Leu Leu Gln Arg Gln Gln Arg 
1               5                   10                  15      


Ala Arg Gln Glu Leu Glu Ala Arg Gln Gln Leu Pro Pro Asp Pro Pro 
            20                  25                  30          


Ala Ala Pro Pro Gly Arg Ala Arg Ala Ala Pro Asp Glu Asp Arg Glu 
        35                  40                  45              


Pro Glu Ser Ala Arg Met Gln Arg Ala Gln Met Ala Ala Leu Ala Ala 
    50                  55                  60                  


Met Arg Ala Ala Ala Ala Gly Leu Gly His Pro Ala Ser Pro Gly Gly 
65                  70                  75                  80  


Ser Glu Asp Gly Pro Pro Gly Ser Glu Glu Glu Asp Ala Ala Arg Glu 
                85                  90                  95      


Gly Thr Pro Gly Ser Pro Gly Arg Gly Arg Glu Gly Pro Gly Glu Glu 
            100                 105                 110         


His Phe Glu Asp Met Ala Ser Asp Glu Asp Met Lys Pro Lys Trp Glu 
        115                 120                 125             


Glu Glu Glu Met Glu Glu Asp Leu Gly Glu Asp Glu Glu Glu Glu Glu 
    130                 135                 140                 


Glu Asp Tyr Glu Asp Glu Glu Glu Glu Glu Asp Glu Glu Gly Leu Gly 
145                 150                 155                 160 


Pro Pro Gly Pro Ala Ser Leu Gly Thr Thr Ala Leu Phe Pro Arg Lys 
                165                 170                 175     


Ala Gln Pro Pro Gln Ala Phe Arg Gly Asp Gly Val Pro Arg Val Leu 
            180                 185                 190         


Gly Gly Gln Glu Arg Pro Gly Pro Gly Pro Ala His Pro Gly Gly Ala 
        195                 200                 205             


Ala His Val Ala Pro Gln Leu Gln Pro Pro Asp His Gly Asp Trp Thr 
    210                 215                 220                 


Tyr Glu Glu Gln Phe Lys Gln Leu Tyr Glu Leu Asp Gly Asp Pro Lys 
225                 230                 235                 240 


Arg Lys Glu Phe Leu Asp Asp Leu Phe Ser Phe Met Gln Lys Arg Gly 
                245                 250                 255     


Thr Pro Val Asn Arg Ile Pro Ile Met Ala Lys Gln Val Leu Asp Leu 
            260                 265                 270         


Phe Met Leu Tyr Val Leu Val Thr Glu Lys Gly Gly Leu Val Glu Val 
        275                 280                 285             


Ile Asn Lys Lys Leu Trp Arg Glu Ile Thr Lys Gly Leu Asn Leu Pro 
    290                 295                 300                 


Thr Ser Ile Thr Ser Ala Ala Phe Thr Leu Arg Thr Gln Tyr Met Lys 
305                 310                 315                 320 


Tyr Leu Tyr Pro Tyr Glu Cys Glu Lys Arg Gly Leu Ser Asn Pro Asn 
                325                 330                 335     


Glu Leu Gln Ala Ala Ile Asp Ser Asn Arg Arg Glu Gly Arg Arg Gln 
            340                 345                 350         


Ser Phe Gly Gly Ser Leu Phe Ala Tyr Ser Pro Gly Gly Ala His Gly 
        355                 360                 365             


Met Leu Ser Ser Pro Lys Leu Pro Val Ser Ser Leu Gly Leu Ala Ala 
    370                 375                 380                 


Ser Thr Asn Gly Ser Ser Ile Thr Pro Ala Pro Lys Ile Lys Lys Glu 
385                 390                 395                 400 


Glu Asp Ser Ala Ile Pro Ile Thr Val Pro Gly Arg Leu Pro Val Ser 
                405                 410                 415     


Leu Ala Gly His Pro Val Val Ala Ala Gln Ala Ala Ala Val Gln Ala 
            420                 425                 430         


Ala Ala Ala Gln Ala Ala Val Ala Ala Gln Ala Ala Ala Leu Glu Gln 
        435                 440                 445             


Leu Arg Glu Lys Leu Glu Ser Ala Glu Pro Pro Glu Lys Lys Met Ala 
    450                 455                 460                 


Leu Val Ala Asp Glu Gln Gln Arg Leu Met Gln Arg Ala Leu Gln Gln 
465                 470                 475                 480 


Asn Phe Leu Ala Met Ala Ala Gln Leu Pro Met Ser Ile Arg Ile Asn 
                485                 490                 495     


Ser Gln Ala Ser Glu Ser Arg Gln Asp Ser Ala Val Asn Leu Thr Gly 
            500                 505                 510         


Thr Asn Gly Ser Asn Ser Ile Ser Met Ser Val Glu Ile Asn Gly Ile 
        515                 520                 525             


Met Tyr Thr Gly Val Leu Phe Ala Gln Pro Pro Ala Pro Thr Pro Thr 
    530                 535                 540                 


Ser Ala Pro Asn Lys Gly Gly Gly Gly Gly Gly Gly Ser Ser Ser Asn 
545                 550                 555                 560 


Ala Gly Gly Arg Gly Gly Asn Thr Gly Thr Ser Gly Gly Gln Ala Gly 
                565                 570                 575     


Pro Ala Gly Leu Ser Thr Pro Ser Thr Ser Thr Ser Asn Asn Ser Leu 
            580                 585                 590         


Pro 
    


<210>  3
<211>  34
<212>  PRT
<213>  Artificial

<220>
<223>  Synthetic peptide

<400>  3

Gln Ala Ala Thr Ala Thr Arg Gly Arg Ser Ala Ala Ser Arg Pro Thr 
1               5                   10                  15      


Glu Arg Pro Arg Ala Pro Ala Arg Ser Ala Ser Arg Pro Arg Arg Pro 
            20                  25                  30          


Val Glu 
        


<210>  4
<211>  16
<212>  PRT
<213>  Artificial

<220>
<223>  Synthetic peptide

<400>  4

Arg Gln Ile Lys Ile Trp Phe Gln Asn Arg Arg Met Lys Trp Lys Lys 
1               5                   10                  15      


<210>  5
<211>  7
<212>  PRT
<213>  Artificial

<220>
<223>  Synthetic peptide

<400>  5

Arg Arg Met Lys Trp Lys Lys 
1               5           


<210>  6
<211>  16
<212>  PRT
<213>  Artificial

<220>
<223>  Synthetic peptide

<400>  6

Arg Arg Trp Arg Arg Trp Trp Arg Arg Trp Trp Arg Arg Trp Arg Arg 
1               5                   10                  15      


<210>  7
<211>  18
<212>  PRT
<213>  Artificial

<220>
<223>  Synthetic peptide

<400>  7

Arg Gly Gly Arg Leu Ser Tyr Ser Arg Arg Arg Phe Ser Thr Ser Thr 
1               5                   10                  15      


Gly Arg 
        


<210>  8
<211>  11
<212>  PRT
<213>  Artificial

<220>
<223>  Synthetic peptide

<400>  8

Tyr Gly Arg Lys Lys Arg Arg Gln Arg Arg Arg 
1               5                   10      


<210>  9
<211>  9
<212>  PRT
<213>  Artificial

<220>
<223>  Synthetic peptide

<400>  9

Arg Lys Lys Arg Arg Gln Arg Arg Arg 
1               5                   


<210>  10
<211>  11
<212>  PRT
<213>  Artificial

<220>
<223>  Synthetic peptide

<400>  10

Tyr Ala Arg Ala Ala Ala Arg Gln Ala Arg Ala 
1               5                   10      


<210>  11
<211>  8
<212>  PRT
<213>  Artificial

<220>
<223>  Synthetic peptide

<400>  11

Arg Arg Arg Arg Arg Arg Arg Arg 
1               5               


<210>  12
<211>  8
<212>  PRT
<213>  Artificial

<220>
<223>  Synthetic peptide

<400>  12

Lys Lys Lys Lys Lys Lys Lys Lys 
1               5               


<210>  13
<211>  27
<212>  PRT
<213>  Artificial

<220>
<223>  Synthetic peptide


<220>
<221>  misc_feature
<222>  (25)..(25)
<223>  Xaa can be any naturally occurring amino acid

<400>  13

Gly Trp Thr Leu Asn Ser Ala Gly Tyr Leu Leu Gly Lys Ile Asn Leu 
1               5                   10                  15      


Lys Ala Leu Ala Ala Leu Ala Lys Xaa Ile Leu 
            20                  25          


<210>  14
<211>  18
<212>  PRT
<213>  Artificial

<220>
<223>  Synthetic peptide

<400>  14

Leu Leu Ile Leu Leu Arg Arg Arg Ile Arg Lys Gln Ala Asn Ala His 
1               5                   10                  15      


Ser Lys 
        


<210>  15
<211>  16
<212>  PRT
<213>  Artificial

<220>
<223>  Synthetic peptide

<400>  15

Ser Arg Arg His His Cys Arg Ser Lys Ala Lys Arg Ser Arg His His 
1               5                   10                  15      


<210>  16
<211>  11
<212>  PRT
<213>  Artificial

<220>
<223>  Synthetic peptide

<400>  16

Asn Arg Ala Arg Arg Asn Arg Arg Arg Val Arg 
1               5                   10      


<210>  17
<211>  15
<212>  PRT
<213>  Artificial

<220>
<223>  Synthetic peptide

<400>  17

Arg Gln Leu Arg Ile Ala Gly Arg Arg Leu Arg Gly Arg Ser Arg 
1               5                   10                  15  


<210>  18
<211>  13
<212>  PRT
<213>  Artificial

<220>
<223>  Synthetic peptide

<400>  18

Lys Leu Ile Lys Gly Arg Thr Pro Ile Lys Phe Gly Lys 
1               5                   10              


<210>  19
<211>  10
<212>  PRT
<213>  Artificial

<220>
<223>  Synthetic peptide

<400>  19

Arg Arg Ile Pro Asn Arg Arg Pro Arg Arg 
1               5                   10  


<210>  20
<211>  18
<212>  PRT
<213>  Artificial

<220>
<223>  Synthetic peptide

<400>  20

Lys Leu Ala Leu Lys Leu Ala Leu Lys Ala Leu Lys Ala Ala Leu Lys 
1               5                   10                  15      


Leu Ala 
        


<210>  21
<211>  14
<212>  PRT
<213>  Artificial

<220>
<223>  Synthetic peptide

<400>  21

Lys Leu Ala Lys Leu Ala Lys Lys Leu Ala Lys Leu Ala Lys 
1               5                   10                  


<210>  22
<211>  27
<212>  PRT
<213>  Artificial

<220>
<223>  Synthetic peptide

<400>  22

Gly Ala Leu Phe Leu Gly Phe Leu Gly Ala Ala Gly Ser Thr Asn Gly 
1               5                   10                  15      


Ala Trp Ser Gln Pro Lys Lys Lys Arg Lys Val 
            20                  25          


<210>  23
<211>  21
<212>  PRT
<213>  Artificial

<220>
<223>  Synthetic peptide

<400>  23

Lys Glu Thr Trp Trp Glu Thr Trp Trp Thr Glu Trp Ser Gln Pro Lys 
1               5                   10                  15      


Lys Lys Arg Lys Val 
            20      


<210>  24
<211>  23
<212>  PRT
<213>  Artificial

<220>
<223>  Synthetic peptide

<400>  24

Gly Ala Leu Phe Leu Gly Trp Leu Gly Ala Ala Gly Ser Thr Met Gly 
1               5                   10                  15      


Ala Lys Lys Lys Arg Lys Val 
            20              


<210>  25
<211>  23
<212>  PRT
<213>  Artificial

<220>
<223>  Synthetic peptide

<400>  25

Met Gly Leu Gly Leu His Leu Leu Val Leu Ala Ala Ala Leu Gln Gly 
1               5                   10                  15      


Ala Lys Ser Lys Arg Lys Val 
            20              


<210>  26
<211>  26
<212>  PRT
<213>  Artificial

<220>
<223>  Synthetic peptide

<400>  26

Ala Ala Val Ala Leu Leu Pro Ala Val Leu Leu Ala Leu Leu Ala Pro 
1               5                   10                  15      


Ala Ala Ala Asn Tyr Lys Lys Pro Lys Leu 
            20                  25      


<210>  27
<211>  28
<212>  PRT
<213>  Artificial

<220>
<223>  Synthetic peptide

<400>  27

Met Ala Asn Leu Gly Tyr Trp Leu Leu Ala Leu Phe Val Thr Met Trp 
1               5                   10                  15      


Thr Asp Val Gly Leu Cys Lys Lys Arg Pro Lys Pro 
            20                  25              


<210>  28
<211>  24
<212>  PRT
<213>  Artificial

<220>
<223>  Synthetic peptide

<400>  28

Leu Gly Thr Tyr Thr Gln Asp Phe Asn Lys Phe His Thr Phe Pro Gln 
1               5                   10                  15      


Thr Ala Ile Gly Val Gly Ala Pro 
            20                  


<210>  29
<211>  26
<212>  PRT
<213>  Artificial

<220>
<223>  Synthetic peptide


<220>
<221>  misc_feature
<222>  (24)..(24)
<223>  Xaa can be any naturally occurring amino acid

<400>  29

Asp Pro Lys Gly Asp Pro Lys Gly Val Thr Val Thr Val Thr Val Thr 
1               5                   10                  15      


Val Thr Gly Lys Gly Asp Pro Xaa Pro Asp 
            20                  25      


<210>  30
<211>  14
<212>  PRT
<213>  Artificial

<220>
<223>  Synthetic peptide

<400>  30

Pro Pro Pro Pro Pro Pro Pro Pro Pro Pro Pro Pro Pro Pro 
1               5                   10                  


<210>  31
<211>  18
<212>  PRT
<213>  Artificial

<220>
<223>  Synthetic peptide

<400>  31

Val Arg Leu Pro Pro Pro Val Arg Leu Pro Pro Pro Val Arg Leu Pro 
1               5                   10                  15      


Pro Pro 
        


<210>  32
<211>  10
<212>  PRT
<213>  Artificial

<220>
<223>  Synthetic peptide

<400>  32

Pro Arg Pro Leu Pro Pro Pro Arg Pro Gly 
1               5                   10  


<210>  33
<211>  30
<212>  PRT
<213>  Artificial

<220>
<223>  Synthetic peptide

<400>  33

Ser Val Arg Arg Arg Pro Arg Pro Pro Tyr Leu Pro Arg Pro Arg Pro 
1               5                   10                  15      


Pro Pro Phe Phe Pro Pro Arg Leu Pro Pro Arg Ile Pro Pro 
            20                  25                  30  


<210>  34
<211>  21
<212>  PRT
<213>  Artificial

<220>
<223>  Synthetic peptide

<400>  34

Thr Arg Ser Ser Arg Ala Gly Leu Gln Phe Pro Val Gly Arg Val His 
1               5                   10                  15      


Arg Leu Leu Arg Lys 
            20      


<210>  35
<211>  23
<212>  PRT
<213>  Artificial

<220>
<223>  Synthetic peptide

<400>  35

Gly Ile Gly Lys Phe Leu His Ser Ala Lys Lys Phe Gly Lys Ala Phe 
1               5                   10                  15      


Val Gly Glu Ile Met Asn Ser 
            20              


<210>  36
<211>  37
<212>  PRT
<213>  Artificial

<220>
<223>  Synthetic peptide

<400>  36

Lys Trp Lys Leu Phe Lys Lys Ile Glu Lys Val Gly Gln Asn Ile Arg 
1               5                   10                  15      


Asp Gly Ile Ile Lys Ala Gly Pro Ala Val Ala Val Val Gly Gln Ala 
            20                  25                  30          


Thr Gln Ile Ala Lys 
        35          


<210>  37
<211>  28
<212>  PRT
<213>  Artificial

<220>
<223>  Synthetic peptide

<400>  37

Ala Leu Trp Met Thr Leu Leu Lys Lys Val Leu Lys Ala Ala Ala Lys 
1               5                   10                  15      


Ala Ala Leu Asn Ala Val Leu Val Gly Ala Asn Ala 
            20                  25              


<210>  38
<211>  26
<212>  PRT
<213>  Artificial

<220>
<223>  Synthetic peptide

<400>  38

Gly Ile Gly Ala Val Leu Lys Val Leu Thr Thr Gly Leu Pro Ala Leu 
1               5                   10                  15      


Ile Ser Trp Ile Lys Arg Lys Arg Gln Gln 
            20                  25      


<210>  39
<211>  14
<212>  PRT
<213>  Artificial

<220>
<223>  Synthetic peptide

<400>  39

Ile Asn Leu Lys Ala Leu Ala Ala Leu Ala Lys Lys Ile Leu 
1               5                   10                  


<210>  40
<211>  33
<212>  PRT
<213>  Artificial

<220>
<223>  Synthetic peptide

<400>  40

Gly Phe Phe Ala Leu Ile Pro Lys Ile Ile Ser Ser Pro Leu Pro Lys 
1               5                   10                  15      


Thr Leu Leu Ser Ala Val Gly Ser Ala Leu Gly Gly Ser Gly Gly Gln 
            20                  25                  30          


Glu 
    


<210>  41
<211>  15
<212>  PRT
<213>  Artificial

<220>
<223>  Synthetic peptide

<400>  41

Leu Ala Lys Trp Ala Leu Lys Gln Gly Phe Ala Lys Leu Lys Ser 
1               5                   10                  15  


<210>  42
<211>  27
<212>  PRT
<213>  Artificial

<220>
<223>  Synthetic peptide


<220>
<221>  misc_feature
<222>  (23)..(23)
<223>  Xaa can be any naturally occurring amino acid

<400>  42

Ser Met Ala Gln Asp Ile Ile Ser Thr Ile Gly Asp Leu Val Lys Trp 
1               5                   10                  15      


Ile Ile Gln Thr Val Asn Xaa Phe Thr Lys Lys 
            20                  25          


<210>  43
<211>  41
<212>  PRT
<213>  Artificial

<220>
<223>  Synthetic peptide

<400>  43

Leu Leu Gly Asp Phe Phe Arg Lys Ser Lys Glu Lys Ile Gly Lys Glu 
1               5                   10                  15      


Phe Lys Arg Ile Val Gln Arg Ile Lys Gln Arg Ile Lys Asp Phe Leu 
            20                  25                  30          


Ala Asn Leu Val Pro Arg Thr Glu Ser 
        35                  40      


<210>  44
<211>  20
<212>  PRT
<213>  Artificial

<220>
<223>  Synthetic peptide

<400>  44

Leu Lys Lys Leu Leu Lys Lys Leu Leu Lys Lys Leu Leu Lys Lys Leu 
1               5                   10                  15      


Leu Lys Lys Leu 
            20  


<210>  45
<211>  18
<212>  PRT
<213>  Artificial

<220>
<223>  Synthetic peptide

<400>  45

Lys Leu Lys Leu Lys Leu Lys Leu Lys Leu Lys Leu Lys Leu Lys Leu 
1               5                   10                  15      


Lys Leu 
        


<210>  46
<211>  18
<212>  PRT
<213>  Artificial

<220>
<223>  Synthetic peptide

<400>  46

Pro Ala Trp Arg Lys Ala Phe Arg Trp Ala Trp Arg Met Leu Lys Lys 
1               5                   10                  15      


Ala Ala 
        


