                         SEQUENCE LISTING

<110>  Mor Research Applications Ltd.
       Pollack, Ayala
       Dvashi, Zeev
 
<120>  COMPOSITIONS AND METHODS FOR TREATMENT OF RETINAL DEGENERATIVE 
       DISEASES

<130>  3044/5.2

<150>  US 61/828701
<151>  2013-05-30

<160>  5     

<170>  PatentIn version 3.5

<210>  1
<211>  579
<212>  PRT
<213>  Homo sapiens

<400>  1

Met Ser Thr Ala Ser Ala Ala Ser Ser Ser Ser Ser Ser Ser Ala Gly 
1               5                   10                  15      


Glu Met Ile Glu Ala Pro Ser Gln Val Leu Asn Phe Glu Glu Ile Asp 
            20                  25                  30          


Tyr Lys Glu Ile Glu Val Glu Glu Val Val Gly Arg Gly Ala Phe Gly 
        35                  40                  45              


Val Val Cys Lys Ala Lys Trp Arg Ala Lys Asp Val Ala Ile Lys Gln 
    50                  55                  60                  


Ile Glu Ser Glu Ser Glu Arg Lys Ala Phe Ile Val Glu Leu Arg Gln 
65                  70                  75                  80  


Leu Ser Arg Val Asn His Pro Asn Ile Val Lys Leu Tyr Gly Ala Cys 
                85                  90                  95      


Leu Asn Pro Val Cys Leu Val Met Glu Tyr Ala Glu Gly Gly Ser Leu 
            100                 105                 110         


Tyr Asn Val Leu His Gly Ala Glu Pro Leu Pro Tyr Tyr Thr Ala Ala 
        115                 120                 125             


His Ala Met Ser Trp Cys Leu Gln Cys Ser Gln Gly Val Ala Tyr Leu 
    130                 135                 140                 


His Ser Met Gln Pro Lys Ala Leu Ile His Arg Asp Leu Lys Pro Pro 
145                 150                 155                 160 


Asn Leu Leu Leu Val Ala Gly Gly Thr Val Leu Lys Ile Cys Asp Phe 
                165                 170                 175     


Gly Thr Ala Cys Asp Ile Gln Thr His Met Thr Asn Asn Lys Gly Ser 
            180                 185                 190         


Ala Ala Trp Met Ala Pro Glu Val Phe Glu Gly Ser Asn Tyr Ser Glu 
        195                 200                 205             


Lys Cys Asp Val Phe Ser Trp Gly Ile Ile Leu Trp Glu Val Ile Thr 
    210                 215                 220                 


Arg Arg Lys Pro Phe Asp Glu Ile Gly Gly Pro Ala Phe Arg Ile Met 
225                 230                 235                 240 


Trp Ala Val His Asn Gly Thr Arg Pro Pro Leu Ile Lys Asn Leu Pro 
                245                 250                 255     


Lys Pro Ile Glu Ser Leu Met Thr Arg Cys Trp Ser Lys Asp Pro Ser 
            260                 265                 270         


Gln Arg Pro Ser Met Glu Glu Ile Val Lys Ile Met Thr His Leu Met 
        275                 280                 285             


Arg Tyr Phe Pro Gly Ala Asp Glu Pro Leu Gln Tyr Pro Cys Gln Tyr 
    290                 295                 300                 


Ser Asp Glu Gly Gln Ser Asn Ser Ala Thr Ser Thr Gly Ser Phe Met 
305                 310                 315                 320 


Asp Ile Ala Ser Thr Asn Thr Ser Asn Lys Ser Asp Thr Asn Met Glu 
                325                 330                 335     


Gln Val Pro Ala Thr Asn Asp Thr Ile Lys Arg Leu Glu Ser Lys Leu 
            340                 345                 350         


Leu Lys Asn Gln Ala Lys Gln Gln Ser Glu Ser Gly Arg Leu Ser Leu 
        355                 360                 365             


Gly Ala Ser Arg Gly Ser Ser Val Glu Ser Leu Pro Pro Thr Ser Glu 
    370                 375                 380                 


Gly Lys Arg Met Ser Ala Asp Met Ser Glu Ile Glu Ala Arg Ile Ala 
385                 390                 395                 400 


Ala Thr Thr Gly Asn Gly Gln Pro Arg Arg Arg Ser Ile Gln Asp Leu 
                405                 410                 415     


Thr Val Thr Gly Thr Glu Pro Gly Gln Val Ser Ser Arg Ser Ser Ser 
            420                 425                 430         


Pro Ser Val Arg Met Ile Thr Thr Ser Gly Pro Thr Ser Glu Lys Pro 
        435                 440                 445             


Thr Arg Ser His Pro Trp Thr Pro Asp Asp Ser Thr Asp Thr Asn Gly 
    450                 455                 460                 


Ser Asp Asn Ser Ile Pro Met Ala Tyr Leu Thr Leu Asp His Gln Leu 
465                 470                 475                 480 


Gln Pro Leu Ala Pro Cys Pro Asn Ser Lys Glu Ser Met Ala Val Phe 
                485                 490                 495     


Glu Gln His Cys Lys Met Ala Gln Glu Tyr Met Lys Val Gln Thr Glu 
            500                 505                 510         


Ile Ala Leu Leu Leu Gln Arg Lys Gln Glu Leu Val Ala Glu Leu Asp 
        515                 520                 525             


Gln Asp Glu Lys Asp Gln Gln Asn Thr Ser Arg Leu Val Gln Glu His 
    530                 535                 540                 


Lys Lys Leu Leu Asp Glu Asn Lys Ser Leu Ser Thr Tyr Tyr Gln Gln 
545                 550                 555                 560 


Cys Lys Lys Gln Leu Glu Val Ile Arg Ser Gln Gln Gln Lys Arg Gln 
                565                 570                 575     


Gly Thr Ser 
            


<210>  2
<211>  606
<212>  PRT
<213>  Homo sapiens

<400>  2

Met Ser Thr Ala Ser Ala Ala Ser Ser Ser Ser Ser Ser Ser Ala Gly 
1               5                   10                  15      


Glu Met Ile Glu Ala Pro Ser Gln Val Leu Asn Phe Glu Glu Ile Asp 
            20                  25                  30          


Tyr Lys Glu Ile Glu Val Glu Glu Val Val Gly Arg Gly Ala Phe Gly 
        35                  40                  45              


Val Val Cys Lys Ala Lys Trp Arg Ala Lys Asp Val Ala Ile Lys Gln 
    50                  55                  60                  


Ile Glu Ser Glu Ser Glu Arg Lys Ala Phe Ile Val Glu Leu Arg Gln 
65                  70                  75                  80  


Leu Ser Arg Val Asn His Pro Asn Ile Val Lys Leu Tyr Gly Ala Cys 
                85                  90                  95      


Leu Asn Pro Val Cys Leu Val Met Glu Tyr Ala Glu Gly Gly Ser Leu 
            100                 105                 110         


Tyr Asn Val Leu His Gly Ala Glu Pro Leu Pro Tyr Tyr Thr Ala Ala 
        115                 120                 125             


His Ala Met Ser Trp Cys Leu Gln Cys Ser Gln Gly Val Ala Tyr Leu 
    130                 135                 140                 


His Ser Met Gln Pro Lys Ala Leu Ile His Arg Asp Leu Lys Pro Pro 
145                 150                 155                 160 


Asn Leu Leu Leu Val Ala Gly Gly Thr Val Leu Lys Ile Cys Asp Phe 
                165                 170                 175     


Gly Thr Ala Cys Asp Ile Gln Thr His Met Thr Asn Asn Lys Gly Ser 
            180                 185                 190         


Ala Ala Trp Met Ala Pro Glu Val Phe Glu Gly Ser Asn Tyr Ser Glu 
        195                 200                 205             


Lys Cys Asp Val Phe Ser Trp Gly Ile Ile Leu Trp Glu Val Ile Thr 
    210                 215                 220                 


Arg Arg Lys Pro Phe Asp Glu Ile Gly Gly Pro Ala Phe Arg Ile Met 
225                 230                 235                 240 


Trp Ala Val His Asn Gly Thr Arg Pro Pro Leu Ile Lys Asn Leu Pro 
                245                 250                 255     


Lys Pro Ile Glu Ser Leu Met Thr Arg Cys Trp Ser Lys Asp Pro Ser 
            260                 265                 270         


Gln Arg Pro Ser Met Glu Glu Ile Val Lys Ile Met Thr His Leu Met 
        275                 280                 285             


Arg Tyr Phe Pro Gly Ala Asp Glu Pro Leu Gln Tyr Pro Cys Gln Tyr 
    290                 295                 300                 


Ser Asp Glu Gly Gln Ser Asn Ser Ala Thr Ser Thr Gly Ser Phe Met 
305                 310                 315                 320 


Asp Ile Ala Ser Thr Asn Thr Ser Asn Lys Ser Asp Thr Asn Met Glu 
                325                 330                 335     


Gln Val Pro Ala Thr Asn Asp Thr Ile Lys Arg Leu Glu Ser Lys Leu 
            340                 345                 350         


Leu Lys Asn Gln Ala Lys Gln Gln Ser Glu Ser Gly Arg Leu Ser Leu 
        355                 360                 365             


Gly Ala Ser Arg Gly Ser Ser Val Glu Ser Leu Pro Pro Thr Ser Glu 
    370                 375                 380                 


Gly Lys Arg Met Ser Ala Asp Met Ser Glu Ile Glu Ala Arg Ile Ala 
385                 390                 395                 400 


Ala Thr Thr Ala Tyr Ser Lys Pro Lys Arg Gly His Arg Lys Thr Ala 
                405                 410                 415     


Ser Phe Gly Asn Ile Leu Asp Val Pro Glu Ile Val Ile Ser Gly Asn 
            420                 425                 430         


Gly Gln Pro Arg Arg Arg Ser Ile Gln Asp Leu Thr Val Thr Gly Thr 
        435                 440                 445             


Glu Pro Gly Gln Val Ser Ser Arg Ser Ser Ser Pro Ser Val Arg Met 
    450                 455                 460                 


Ile Thr Thr Ser Gly Pro Thr Ser Glu Lys Pro Thr Arg Ser His Pro 
465                 470                 475                 480 


Trp Thr Pro Asp Asp Ser Thr Asp Thr Asn Gly Ser Asp Asn Ser Ile 
                485                 490                 495     


Pro Met Ala Tyr Leu Thr Leu Asp His Gln Leu Gln Pro Leu Ala Pro 
            500                 505                 510         


Cys Pro Asn Ser Lys Glu Ser Met Ala Val Phe Glu Gln His Cys Lys 
        515                 520                 525             


Met Ala Gln Glu Tyr Met Lys Val Gln Thr Glu Ile Ala Leu Leu Leu 
    530                 535                 540                 


Gln Arg Lys Gln Glu Leu Val Ala Glu Leu Asp Gln Asp Glu Lys Asp 
545                 550                 555                 560 


Gln Gln Asn Thr Ser Arg Leu Val Gln Glu His Lys Lys Leu Leu Asp 
                565                 570                 575     


Glu Asn Lys Ser Leu Ser Thr Tyr Tyr Gln Gln Cys Lys Lys Gln Leu 
            580                 585                 590         


Glu Val Ile Arg Ser Gln Gln Gln Lys Arg Gln Gly Thr Ser 
        595                 600                 605     


<210>  3
<211>  518
<212>  PRT
<213>  Homo sapiens

<400>  3

Met Ser Thr Ala Ser Ala Ala Ser Ser Ser Ser Ser Ser Ser Ala Gly 
1               5                   10                  15      


Glu Met Ile Glu Ala Pro Ser Gln Val Leu Asn Phe Glu Glu Ile Asp 
            20                  25                  30          


Tyr Lys Glu Ile Glu Val Glu Glu Val Val Gly Arg Gly Ala Phe Gly 
        35                  40                  45              


Val Val Cys Lys Ala Lys Trp Arg Ala Lys Asp Val Ala Ile Lys Gln 
    50                  55                  60                  


Ile Glu Ser Glu Ser Glu Arg Lys Ala Phe Ile Val Glu Leu Arg Gln 
65                  70                  75                  80  


Leu Ser Arg Val Asn His Pro Asn Ile Val Lys Leu Tyr Gly Ala Cys 
                85                  90                  95      


Leu Asn Pro Val Cys Leu Val Met Glu Tyr Ala Glu Gly Gly Ser Leu 
            100                 105                 110         


Tyr Asn Val Leu His Gly Ala Glu Pro Leu Pro Tyr Tyr Thr Ala Ala 
        115                 120                 125             


His Ala Met Ser Trp Cys Leu Gln Cys Ser Gln Gly Val Ala Tyr Leu 
    130                 135                 140                 


His Ser Met Gln Pro Lys Ala Leu Ile His Arg Asp Leu Lys Pro Pro 
145                 150                 155                 160 


Asn Leu Leu Leu Val Ala Gly Gly Thr Val Leu Lys Ile Cys Asp Phe 
                165                 170                 175     


Gly Thr Ala Cys Asp Ile Gln Thr His Met Thr Asn Asn Lys Gly Ser 
            180                 185                 190         


Ala Ala Trp Met Ala Pro Glu Val Phe Glu Gly Ser Asn Tyr Ser Glu 
        195                 200                 205             


Lys Cys Asp Val Phe Ser Trp Gly Ile Ile Leu Trp Glu Val Ile Thr 
    210                 215                 220                 


Arg Arg Lys Pro Phe Asp Glu Ile Gly Gly Pro Ala Phe Arg Ile Met 
225                 230                 235                 240 


Trp Ala Val His Asn Gly Thr Arg Pro Pro Leu Ile Lys Asn Leu Pro 
                245                 250                 255     


Lys Pro Ile Glu Ser Leu Met Thr Arg Cys Trp Ser Lys Asp Pro Ser 
            260                 265                 270         


Gln Arg Pro Ser Met Glu Glu Ile Val Lys Ile Met Thr His Leu Met 
        275                 280                 285             


Arg Tyr Phe Pro Gly Ala Asp Glu Pro Leu Gln Tyr Pro Cys Gln Tyr 
    290                 295                 300                 


Ser Asp Glu Gly Gln Ser Asn Ser Ala Thr Ser Thr Gly Ser Phe Met 
305                 310                 315                 320 


Asp Ile Ala Ser Thr Asn Thr Ser Asn Lys Ser Asp Thr Asn Met Glu 
                325                 330                 335     


Gln Val Pro Ala Thr Asn Asp Thr Ile Lys Arg Leu Glu Ser Lys Leu 
            340                 345                 350         


Leu Lys Asn Gln Ala Lys Gln Gln Ser Glu Ser Gly Arg Leu Ser Leu 
        355                 360                 365             


Gly Ala Ser Arg Gly Ser Ser Val Glu Ser Leu Pro Pro Thr Ser Glu 
    370                 375                 380                 


Gly Lys Arg Met Ser Ala Asp Met Ser Glu Ile Glu Ala Arg Ile Ala 
385                 390                 395                 400 


Ala Thr Thr Ala Tyr Ser Lys Pro Lys Arg Gly His Arg Lys Thr Ala 
                405                 410                 415     


Ser Phe Gly Asn Ile Leu Asp Val Pro Glu Ile Val Ile Ser Gly Asn 
            420                 425                 430         


Gly Gln Pro Arg Arg Arg Ser Ile Gln Asp Leu Thr Val Thr Gly Thr 
        435                 440                 445             


Glu Pro Gly Gln Val Ser Ser Arg Ser Ser Ser Pro Ser Val Arg Met 
    450                 455                 460                 


Ile Thr Thr Ser Gly Pro Thr Ser Glu Lys Pro Thr Arg Ser His Pro 
465                 470                 475                 480 


Trp Thr Pro Asp Asp Ser Thr Asp Thr Asn Gly Ser Asp Asn Ser Ile 
                485                 490                 495     


Pro Met Ala Tyr Leu Thr Leu Asp His Gln Leu Gln Ala Arg Thr Ser 
            500                 505                 510         


Cys Arg Thr Gly Pro Gly 
        515             


<210>  4
<211>  491
<212>  PRT
<213>  Homo sapiens

<400>  4

Met Ser Thr Ala Ser Ala Ala Ser Ser Ser Ser Ser Ser Ser Ala Gly 
1               5                   10                  15      


Glu Met Ile Glu Ala Pro Ser Gln Val Leu Asn Phe Glu Glu Ile Asp 
            20                  25                  30          


Tyr Lys Glu Ile Glu Val Glu Glu Val Val Gly Arg Gly Ala Phe Gly 
        35                  40                  45              


Val Val Cys Lys Ala Lys Trp Arg Ala Lys Asp Val Ala Ile Lys Gln 
    50                  55                  60                  


Ile Glu Ser Glu Ser Glu Arg Lys Ala Phe Ile Val Glu Leu Arg Gln 
65                  70                  75                  80  


Leu Ser Arg Val Asn His Pro Asn Ile Val Lys Leu Tyr Gly Ala Cys 
                85                  90                  95      


Leu Asn Pro Val Cys Leu Val Met Glu Tyr Ala Glu Gly Gly Ser Leu 
            100                 105                 110         


Tyr Asn Val Leu His Gly Ala Glu Pro Leu Pro Tyr Tyr Thr Ala Ala 
        115                 120                 125             


His Ala Met Ser Trp Cys Leu Gln Cys Ser Gln Gly Val Ala Tyr Leu 
    130                 135                 140                 


His Ser Met Gln Pro Lys Ala Leu Ile His Arg Asp Leu Lys Pro Pro 
145                 150                 155                 160 


Asn Leu Leu Leu Val Ala Gly Gly Thr Val Leu Lys Ile Cys Asp Phe 
                165                 170                 175     


Gly Thr Ala Cys Asp Ile Gln Thr His Met Thr Asn Asn Lys Gly Ser 
            180                 185                 190         


Ala Ala Trp Met Ala Pro Glu Val Phe Glu Gly Ser Asn Tyr Ser Glu 
        195                 200                 205             


Lys Cys Asp Val Phe Ser Trp Gly Ile Ile Leu Trp Glu Val Ile Thr 
    210                 215                 220                 


Arg Arg Lys Pro Phe Asp Glu Ile Gly Gly Pro Ala Phe Arg Ile Met 
225                 230                 235                 240 


Trp Ala Val His Asn Gly Thr Arg Pro Pro Leu Ile Lys Asn Leu Pro 
                245                 250                 255     


Lys Pro Ile Glu Ser Leu Met Thr Arg Cys Trp Ser Lys Asp Pro Ser 
            260                 265                 270         


Gln Arg Pro Ser Met Glu Glu Ile Val Lys Ile Met Thr His Leu Met 
        275                 280                 285             


Arg Tyr Phe Pro Gly Ala Asp Glu Pro Leu Gln Tyr Pro Cys Gln Tyr 
    290                 295                 300                 


Ser Asp Glu Gly Gln Ser Asn Ser Ala Thr Ser Thr Gly Ser Phe Met 
305                 310                 315                 320 


Asp Ile Ala Ser Thr Asn Thr Ser Asn Lys Ser Asp Thr Asn Met Glu 
                325                 330                 335     


Gln Val Pro Ala Thr Asn Asp Thr Ile Lys Arg Leu Glu Ser Lys Leu 
            340                 345                 350         


Leu Lys Asn Gln Ala Lys Gln Gln Ser Glu Ser Gly Arg Leu Ser Leu 
        355                 360                 365             


Gly Ala Ser Arg Gly Ser Ser Val Glu Ser Leu Pro Pro Thr Ser Glu 
    370                 375                 380                 


Gly Lys Arg Met Ser Ala Asp Met Ser Glu Ile Glu Ala Arg Ile Ala 
385                 390                 395                 400 


Ala Thr Thr Gly Asn Gly Gln Pro Arg Arg Arg Ser Ile Gln Asp Leu 
                405                 410                 415     


Thr Val Thr Gly Thr Glu Pro Gly Gln Val Ser Ser Arg Ser Ser Ser 
            420                 425                 430         


Pro Ser Val Arg Met Ile Thr Thr Ser Gly Pro Thr Ser Glu Lys Pro 
        435                 440                 445             


Thr Arg Ser His Pro Trp Thr Pro Asp Asp Ser Thr Asp Thr Asn Gly 
    450                 455                 460                 


Ser Asp Asn Ser Ile Pro Met Ala Tyr Leu Thr Leu Asp His Gln Leu 
465                 470                 475                 480 


Gln Ala Arg Thr Ser Cys Arg Thr Gly Pro Gly 
                485                 490     


<210>  5
<211>  504
<212>  PRT
<213>  Homo sapiens

<400>  5

Met Ala Ala Gln Arg Arg Ser Leu Leu Gln Ser Glu Gln Gln Pro Ser 
1               5                   10                  15      


Trp Thr Asp Asp Leu Pro Leu Cys His Leu Ser Gly Val Gly Ser Ala 
            20                  25                  30          


Ser Asn Arg Ser Tyr Ser Ala Asp Gly Lys Gly Thr Glu Ser His Pro 
        35                  40                  45              


Pro Glu Asp Ser Trp Leu Lys Phe Arg Ser Glu Asn Asn Cys Phe Leu 
    50                  55                  60                  


Tyr Gly Val Phe Asn Gly Tyr Asp Gly Asn Arg Val Thr Asn Phe Val 
65                  70                  75                  80  


Ala Gln Arg Leu Ser Ala Glu Leu Leu Leu Gly Gln Leu Asn Ala Glu 
                85                  90                  95      


His Ala Glu Ala Asp Val Arg Arg Val Leu Leu Gln Ala Phe Asp Val 
            100                 105                 110         


Val Glu Arg Ser Phe Leu Glu Ser Ile Asp Asp Ala Leu Ala Glu Lys 
        115                 120                 125             


Ala Ser Leu Gln Ser Gln Leu Pro Glu Gly Val Pro Gln His Gln Leu 
    130                 135                 140                 


Pro Pro Gln Tyr Gln Lys Ile Leu Glu Arg Leu Lys Thr Leu Glu Arg 
145                 150                 155                 160 


Glu Ile Ser Gly Gly Ala Met Ala Val Val Ala Val Leu Leu Asn Asn 
                165                 170                 175     


Lys Leu Tyr Val Ala Asn Val Gly Thr Asn Arg Ala Leu Leu Cys Lys 
            180                 185                 190         


Ser Thr Val Asp Gly Leu Gln Val Thr Gln Leu Asn Val Asp His Thr 
        195                 200                 205             


Thr Glu Asn Glu Asp Glu Leu Phe Arg Leu Ser Gln Leu Gly Leu Asp 
    210                 215                 220                 


Ala Gly Lys Ile Lys Gln Val Gly Ile Ile Cys Gly Gln Glu Ser Thr 
225                 230                 235                 240 


Arg Arg Ile Gly Asp Tyr Lys Val Lys Tyr Gly Tyr Thr Asp Ile Asp 
                245                 250                 255     


Leu Leu Ser Ala Ala Lys Ser Lys Pro Ile Ile Ala Glu Pro Glu Ile 
            260                 265                 270         


His Gly Ala Gln Pro Leu Asp Gly Val Thr Gly Phe Leu Val Leu Met 
        275                 280                 285             


Ser Glu Gly Leu Tyr Lys Ala Leu Glu Ala Ala His Gly Pro Gly Gln 
    290                 295                 300                 


Ala Asn Gln Glu Ile Ala Ala Met Ile Asp Thr Glu Phe Ala Lys Gln 
305                 310                 315                 320 


Thr Ser Leu Asp Ala Val Ala Gln Ala Val Val Asp Arg Val Lys Arg 
                325                 330                 335     


Ile His Ser Asp Thr Phe Ala Ser Gly Gly Glu Arg Ala Arg Phe Cys 
            340                 345                 350         


Pro Arg His Glu Asp Met Thr Leu Leu Val Arg Asn Phe Gly Tyr Pro 
        355                 360                 365             


Leu Gly Glu Met Ser Gln Pro Thr Pro Ser Pro Ala Pro Ala Ala Gly 
    370                 375                 380                 


Gly Arg Val Tyr Pro Val Ser Val Pro Tyr Ser Ser Ala Gln Ser Thr 
385                 390                 395                 400 


Ser Lys Thr Ser Val Thr Leu Ser Leu Val Met Pro Ser Gln Gly Gln 
                405                 410                 415     


Met Val Asn Gly Ala His Ser Ala Ser Thr Leu Asp Glu Ala Thr Pro 
            420                 425                 430         


Thr Leu Thr Asn Gln Ser Pro Thr Leu Thr Leu Gln Ser Thr Asn Thr 
        435                 440                 445             


His Thr Gln Ser Ser Ser Ser Ser Ser Asp Gly Gly Leu Phe Arg Ser 
    450                 455                 460                 


Arg Pro Ala His Ser Leu Pro Pro Gly Glu Asp Gly Arg Val Glu Pro 
465                 470                 475                 480 


Tyr Val Asp Phe Ala Glu Phe Tyr Arg Leu Trp Ser Val Asp His Gly 
                485                 490                 495     


Glu Gln Ser Val Val Thr Ala Pro 
            500                 


