                         SEQUENCE LISTING

<110>  INMUNOVA S.A.
       Spatz, Martin D. L.
 
<120>  ANTIBODIES WHICH BIND SPECIFICALLY THE B SUBUNIT OF THE SHIGA 
       TOXIN

<130>  462-2612 PCT

<150>  US 61/827713
<151>  2013-05-27

<160>  54    

<170>  PatentIn version 3.5

<210>  1
<211>  70
<212>  PRT
<213>  Escherichia coli

<400>  1

Ala Asp Cys Ala Lys Gly Lys Ile Glu Phe Ser Lys Tyr Asn Glu Asp 
1               5                   10                  15      


Asp Thr Phe Thr Val Lys Val Asp Gly Lys Glu Tyr Trp Thr Ser Arg 
            20                  25                  30          


Trp Asn Leu Gln Pro Leu Leu Gln Ser Ala Gln Leu Thr Gly Met Thr 
        35                  40                  45              


Val Thr Ile Lys Ser Ser Thr Cys Glu Ser Gly Ser Gly Phe Ala Glu 
    50                  55                  60                  


Val Gln Phe Asn Asn Asp 
65                  70  


<210>  2
<211>  174
<212>  DNA
<213>  Escherichia coli

<400>  2
aaaattgagt tttccaagta taatgaggat gacacattta cagtgaaggt tgacgggaaa       60

gaatactgga ccagtcgctg gaatctgcaa ccgttactgc aaagtgctca gttgacagga      120

atgactgtca caatcaaatc cagtacctgt gaatcaggct ccggatttgc tgaa            174


<210>  3
<211>  158
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic construct

<400>  3

Ala Ser Asn Gln Ser Cys Pro Asn Lys Thr Ser Phe Lys Ile Ala Phe 
1               5                   10                  15      


Ile Gln Ala Arg Trp His Ala Asp Ile Val Asp Glu Ala Arg Lys Ser 
            20                  25                  30          


Phe Val Ala Glu Leu Ala Ala Lys Thr Gly Gly Ser Val Glu Val Glu 
        35                  40                  45              


Ile Phe Asp Val Pro Gly Ala Tyr Glu Ile Pro Leu His Ala Lys Thr 
    50                  55                  60                  


Leu Ala Arg Thr Gly Arg Tyr Ala Ala Ile Val Gly Ala Ala Phe Val 
65                  70                  75                  80  


Ile Asp Gly Gly Ile Tyr Arg His Asp Phe Val Ala Thr Ala Val Ile 
                85                  90                  95      


Asn Gly Met Met Gln Val Gln Leu Glu Thr Glu Val Pro Val Leu Ser 
            100                 105                 110         


Val Val Leu Thr Pro His His Phe His Glu Ser Lys Glu His His Asp 
        115                 120                 125             


Phe Phe His Ala His Phe Lys Val Lys Gly Val Glu Ala Ala His Ala 
    130                 135                 140                 


Ala Leu Gln Ile Val Ser Glu Arg Ser Arg Ile Ala Leu Val 
145                 150                 155             


<210>  4
<211>  233
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic construct

<400>  4

Met His Ala Asp Cys Ala Lys Gly Lys Ile Glu Phe Ser Lys Tyr Asn 
1               5                   10                  15      


Glu Asp Asp Thr Phe Thr Val Lys Val Asp Gly Lys Glu Tyr Trp Thr 
            20                  25                  30          


Ser Arg Trp Asn Leu Gln Pro Leu Leu Gln Ser Ala Gln Leu Thr Gly 
        35                  40                  45              


Met Thr Val Thr Ile Lys Ser Ser Thr Cys Glu Ser Gly Ser Gly Phe 
    50                  55                  60                  


Ala Glu Val Gln Phe Asn Asn Asp Gly Ser Gly Ser Gly Ser Gly Ser 
65                  70                  75                  80  


Gly Ser Leu Lys Thr Ser Phe Lys Ile Ala Phe Ile Gln Ala Arg Trp 
                85                  90                  95      


His Ala Asp Ile Val Asp Glu Ala Arg Lys Ser Phe Val Ala Glu Leu 
            100                 105                 110         


Ala Ala Lys Thr Gly Gly Ser Val Glu Val Glu Ile Phe Asp Val Pro 
        115                 120                 125             


Gly Ala Tyr Glu Ile Pro Leu His Ala Lys Thr Leu Ala Arg Thr Gly 
    130                 135                 140                 


Arg Tyr Ala Ala Ile Val Gly Ala Ala Phe Val Ile Asp Gly Gly Ile 
145                 150                 155                 160 


Tyr Arg His Asp Phe Val Ala Thr Ala Val Ile Asn Gly Met Met Gln 
                165                 170                 175     


Val Gln Leu Glu Thr Glu Val Pro Val Leu Ser Val Val Leu Thr Pro 
            180                 185                 190         


His His Phe His Glu Ser Lys Glu His His Asp Phe Phe His Ala His 
        195                 200                 205             


Phe Lys Val Lys Gly Val Glu Ala Ala His Ala Ala Leu Gln Ile Val 
    210                 215                 220                 


Ser Glu Arg Ser Arg Ile Ala Leu Val 
225                 230             


<210>  5
<211>  702
<212>  DNA
<213>  Brucella abortus

<400>  5
atgcatgcgg attgtgctaa aggtaaaatt gagttttcca agtataatga ggatgacaca       60

tttacagtga aggttgacgg gaaagaatac tggaccagtc gctggaatct gcaaccgtta      120

ctgcaaagtg ctcagttgac aggaatgact gtcacaatca aatccagtac ctgtgaatca      180

ggctccggat ttgctgaagt gcagtttaat aatgacggtt ctggttctgg ttctggttct      240

ggttctctta agacatcctt taaaatcgca ttcattcagg cccgctggca cgccgacatc      300

gttgacgaag cgcgcaaaag ctttgtcgcc gaactggccg caaagacggg tggcagcgtc      360

gaggtagaga tattcgacgt gccgggtgca tatgaaattc cccttcacgc caagacattg      420

gccagaaccg ggcgctatgc agccatcgtc ggtgcggcct tcgtgatcga cggcggcatc      480

tatcgtcatg atttcgtggc gacggccgtt atcaacggca tgatgcaggt gcagcttgaa      540

acggaagtgc cggtgctgag cgtcgtgctg acgccgcacc atttccatga aagcaaggag      600

catcacgact tcttccatgc tcatttcaag gtgaagggcg tggaagcggc ccatgccgcc      660

ttgcagatcg tgagcgagcg cagccgcatc gcgcttgtct ga                         702


<210>  6
<211>  7
<212>  PRT
<213>  Lama glama


<220>
<221>  MISC_FEATURE
<222>  (5)..(5)
<223>  X = S, T or A

<400>  6

Asn Leu Arg Gly Xaa Asn Tyr 
1               5           


<210>  7
<211>  113
<212>  PRT
<213>  Lama glama

<400>  7

Glu Val Gln Leu Gln Glu Ser Gly Gly Gly Leu Val Gln Pro Gly Gly 
1               5                   10                  15      


Ser Leu Lys Leu Ala Cys Ala Ala Ser Gly Ile Thr Phe Arg Asn Lys 
            20                  25                  30          


Ala Ile Gly Trp Tyr Arg Gln Ala Pro Gly Lys Gly Leu Glu Leu Val 
        35                  40                  45              


Ala Arg Ile Asp Ser Phe Asp Thr Thr Asp Tyr Ala Asp Ser Val Lys 
    50                  55                  60                  


Gly Arg Phe Ser Ile Ser Arg Asp Asn Ser Lys Asn Thr Leu Tyr Leu 
65                  70                  75                  80  


Gln Met Asn Ser Leu Arg Ala Glu Asp Thr Ala Val Tyr Tyr Cys Asn 
                85                  90                  95      


Leu Arg Gly Ser Asn Tyr Trp Gly Gln Gly Thr Leu Val Thr Val Ser 
            100                 105                 110         


Ser 
    


<210>  8
<211>  113
<212>  PRT
<213>  Lama glama

<400>  8

Glu Val Gln Leu Gln Glu Ser Gly Gly Gly Leu Val Gln Pro Gly Gly 
1               5                   10                  15      


Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Ile Thr Phe Arg Asn Lys 
            20                  25                  30          


Ala Ile Gly Trp Tyr Arg Gln Ala Pro Gly Lys Gly Leu Glu Leu Val 
        35                  40                  45              


Ala Arg Ile Asp Ser Phe Asp Thr Thr Asp Tyr Ala Asp Ser Val Lys 
    50                  55                  60                  


Gly Arg Phe Thr Ile Ser Arg Asp Asn Ser Lys Asn Thr Leu Tyr Leu 
65                  70                  75                  80  


Gln Met Asn Ser Leu Arg Ala Glu Asp Thr Ala Val Tyr Tyr Cys Asn 
                85                  90                  95      


Leu Arg Gly Ser Asn Tyr Trp Gly Gln Gly Thr Leu Val Thr Val Ser 
            100                 105                 110         


Ser 
    


<210>  9
<211>  113
<212>  PRT
<213>  Lama glama

<400>  9

Gln Val Gln Leu Gln Glu Ser Gly Gly Gly Leu Val Gln Pro Gly Gly 
1               5                   10                  15      


Ser Leu Lys Leu Ala Cys Ala Ala Ser Gly Ile Thr Phe Arg Asn Lys 
            20                  25                  30          


Ala Ile Gly Trp Tyr Arg Gln Ala Pro Gly Lys Gly Arg Glu Leu Val 
        35                  40                  45              


Ala Arg Ile Asp Ser Phe Asp Thr Thr Asp Tyr Ala Asp Ser Val Lys 
    50                  55                  60                  


Gly Arg Phe Ser Ile Ser Arg Asp Asn Ala Lys Asn Thr Val Tyr Leu 
65                  70                  75                  80  


Gln Met Asn Ser Leu Lys Ser Glu Asp Thr Ala Val Tyr Tyr Cys Asn 
                85                  90                  95      


Leu Arg Gly Ser Asn Tyr Trp Gly Gln Gly Thr Gln Val Thr Val Ser 
            100                 105                 110         


Ser 
    


<210>  10
<211>  113
<212>  PRT
<213>  Lama glama

<400>  10

Gln Val Gln Leu Gln Glu Ser Gly Gly Gly Leu Val Gln Ala Gly Gly 
1               5                   10                  15      


Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Ile Thr Phe Arg Arg Lys 
            20                  25                  30          


Ala Ile Gly Trp Tyr Arg Gln Ala Pro Gly Lys Gln Arg Glu Leu Val 
        35                  40                  45              


Ala Arg Ile Asp Ser Asp Asp Ile Thr Asp Tyr Ala Asp Ser Val Lys 
    50                  55                  60                  


Gly Arg Phe Ser Ile Ser Arg Asp Asn Ala Lys Asn Thr Val Tyr Leu 
65                  70                  75                  80  


Gln Met Asn Ser Leu Lys Ser Glu Asp Thr Ala Val Tyr Tyr Cys Asn 
                85                  90                  95      


Leu Arg Gly Ser Asn Tyr Trp Gly Gln Gly Thr Gln Val Thr Val Ser 
            100                 105                 110         


Ser 
    


<210>  11
<211>  113
<212>  PRT
<213>  Lama glama

<400>  11

Gln Val Gln Leu Gln Glu Ser Gly Gly Gly Leu Val Gln Ala Gly Gly 
1               5                   10                  15      


Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Ile Thr Phe Arg Arg Lys 
            20                  25                  30          


Ala Ile Gly Trp Tyr Arg Gln Ala Pro Gly Lys Gln Arg Glu Leu Val 
        35                  40                  45              


Ala Arg Ile Asp Ser Asp Asp Ile Thr Asp Tyr Ala Asp Ser Val Lys 
    50                  55                  60                  


Gly Arg Phe Ser Ile Ser Arg Asp Asn Ala Lys Asn Met Val Tyr Leu 
65                  70                  75                  80  


Gln Met Asn Ser Leu Lys Ser Glu Asp Thr Ala Val Tyr Tyr Cys Asn 
                85                  90                  95      


Leu Arg Gly Ser Asn Tyr Trp Gly Gln Gly Thr Gln Val Thr Val Ser 
            100                 105                 110         


Ser 
    


<210>  12
<211>  113
<212>  PRT
<213>  Lama glama

<400>  12

Gln Val Gln Leu Gln Glu Ser Gly Gly Gly Leu Val Gln Ala Gly Gly 
1               5                   10                  15      


Ser Leu Arg Ile Ser Cys Ala Ala Ser Gly Ile Thr Phe Arg Arg Arg 
            20                  25                  30          


Ala Ile Gly Trp Tyr Arg Gln Ala Pro Gly Lys Gln Arg Glu Leu Val 
        35                  40                  45              


Ala Arg Ile Asp Ser Asp Asp Ile Thr Asn Tyr Ala Asp Ser Val Lys 
    50                  55                  60                  


Gly Arg Phe Ser Ile Ser Arg Asp Asn Ala Lys Asn Thr Val Phe Leu 
65                  70                  75                  80  


Gln Met Asn Ser Leu Lys Ser Glu Asp Thr Ala Ile Tyr Tyr Cys Asn 
                85                  90                  95      


Leu Arg Gly Ser Asn Tyr Trp Gly Gln Gly Thr Gln Val Thr Val Ser 
            100                 105                 110         


Ser 
    


<210>  13
<211>  113
<212>  PRT
<213>  Lama glama

<400>  13

Gln Val Gln Leu Gln Glu Ser Gly Gly Gly Leu Val Gln Ala Gly Gly 
1               5                   10                  15      


Ser Leu Arg Ile Ser Cys Ala Ala Ser Gly Ile Thr Phe Arg Arg Lys 
            20                  25                  30          


Ala Ile Gly Trp Tyr Arg Gln Ala Pro Gly Lys Gln Arg Glu Leu Val 
        35                  40                  45              


Ala Arg Ile Asp Ser Asp Asp Ile Thr Asn Tyr Ala Asp Ser Val Lys 
    50                  55                  60                  


Gly Arg Phe Ser Ile Ser Arg Asp Asn Ala Lys Asn Thr Val Phe Leu 
65                  70                  75                  80  


Gln Met Asn Ser Leu Lys Ser Glu Asp Thr Ala Ile Tyr Tyr Cys Asn 
                85                  90                  95      


Leu Arg Gly Ser Asn Tyr Trp Gly Gln Gly Thr Gln Val Thr Val Ser 
            100                 105                 110         


Ser 
    


<210>  14
<211>  113
<212>  PRT
<213>  Lama glama

<400>  14

Gln Val Gln Leu Gln Glu Ser Gly Gly Gly Leu Val Gln Ala Gly Gly 
1               5                   10                  15      


Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Ile Thr Phe Arg Arg Lys 
            20                  25                  30          


Ala Ile Gly Trp Tyr Arg Gln Ala Pro Gly Lys Gln Arg Glu Leu Val 
        35                  40                  45              


Ala Arg Ile Asp Ser Asp Asp Ile Thr Asn Tyr Ala Asp Ser Val Lys 
    50                  55                  60                  


Gly Arg Phe Ser Ile Ser Arg Asp Asn Ala Lys Asn Thr Val Phe Leu 
65                  70                  75                  80  


Gln Met Asn Ser Leu Lys Ser Glu Asp Thr Ala Val Tyr Tyr Cys Asn 
                85                  90                  95      


Leu Arg Gly Ser Asn Tyr Trp Gly Gln Gly Thr Gln Val Thr Val Ser 
            100                 105                 110         


Ser 
    


<210>  15
<211>  113
<212>  PRT
<213>  Lama glama

<400>  15

Gln Val Gln Leu Gln Glu Ser Gly Gly Gly Leu Val Gln Pro Gly Gly 
1               5                   10                  15      


Ser Leu Arg Leu Ser Cys Val Ala Ser Gly Phe Ser Phe Arg Arg Lys 
            20                  25                  30          


Ala Ile Gly Trp Tyr Arg Gln Ala Pro Gly Lys Gln Arg Glu Leu Val 
        35                  40                  45              


Ala Arg Ile Asp Ser Asp Asp Ile Thr Asn Tyr Ala Asp Ser Val Lys 
    50                  55                  60                  


Gly Arg Phe Ser Ile Ser Arg Asp Asn Ala Lys Asn Thr Val Phe Leu 
65                  70                  75                  80  


Gln Met Asn Ser Leu Lys Ser Glu Asp Thr Ala Val Tyr Tyr Cys Asn 
                85                  90                  95      


Leu Arg Gly Ser Asn Tyr Trp Gly Gln Gly Thr Gln Val Thr Val Ser 
            100                 105                 110         


Ser 
    


<210>  16
<211>  113
<212>  PRT
<213>  Lama glama

<400>  16

Gln Val Gln Leu Gln Glu Ser Gly Gly Gly Leu Val Gln Pro Gly Gly 
1               5                   10                  15      


Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Ile Thr Phe Arg Asn Lys 
            20                  25                  30          


Ala Ile Gly Trp Tyr Arg Gln Ala Pro Gly Lys Gln Arg Glu Leu Val 
        35                  40                  45              


Ala Arg Ile Asp Ser Gly Asp Ile Thr Asp Tyr Ala Asp Ser Val Lys 
    50                  55                  60                  


Gly Arg Phe Ser Ile Ser Arg Asp Asn Ala Lys Asn Thr Val Tyr Leu 
65                  70                  75                  80  


Gln Met Asn Ser Leu Lys Ser Glu Asp Thr Ala Val Tyr Tyr Cys Asn 
                85                  90                  95      


Leu Arg Gly Ser Asn Tyr Trp Gly Gln Gly Thr Gln Val Thr Val Ser 
            100                 105                 110         


Ser 
    


<210>  17
<211>  113
<212>  PRT
<213>  Lama glama

<400>  17

Gln Val Gln Leu Gln Glu Ser Gly Gly Gly Leu Val Gln Ala Gly Gly 
1               5                   10                  15      


Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Ile Thr Phe Arg Gly Lys 
            20                  25                  30          


Ala Ile Gly Trp Tyr Arg Gln Ala Pro Gly Lys Gln Arg Glu Leu Val 
        35                  40                  45              


Ala Arg Ile Asp Ser Gly Asp Ile Thr Asp Tyr Ala Asp Ser Val Lys 
    50                  55                  60                  


Gly Arg Phe Ser Ile Ser Arg Asp Asn Ala Lys Asn Thr Val Tyr Leu 
65                  70                  75                  80  


Gln Met Asn Ser Leu Lys Ser Glu Asp Thr Ala Val Tyr Tyr Cys Asn 
                85                  90                  95      


Leu Arg Gly Ser Asn Tyr Trp Gly Gln Gly Thr Gln Val Thr Val Ser 
            100                 105                 110         


Ser 
    


<210>  18
<211>  113
<212>  PRT
<213>  Lama glama

<400>  18

Gln Val Gln Leu Gln Glu Ser Gly Gly Gly Leu Val Gln Ala Gly Gly 
1               5                   10                  15      


Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Ile Ile Phe Arg Asn Lys 
            20                  25                  30          


Ala Ile Gly Trp Tyr Arg Gln Ala Pro Gly Lys Gln Arg Glu Leu Val 
        35                  40                  45              


Ala Arg Ile Asp Ser Tyr Asp Ser Thr Val Tyr Ala Asp Ser Val Lys 
    50                  55                  60                  


Gly Arg Phe Ser Ile Ser Arg Asp Asn Ala Lys Asn Thr Val Tyr Leu 
65                  70                  75                  80  


Gln Met Asn Asn Pro Lys Ser Glu Asp Thr Ala Val Tyr Tyr Cys Asn 
                85                  90                  95      


Leu Arg Gly Ser Asn Tyr Trp Gly Gln Gly Thr Gln Val Thr Val Ser 
            100                 105                 110         


Ser 
    


<210>  19
<211>  113
<212>  PRT
<213>  Lama glama

<400>  19

Gln Val Gln Leu Gln Glu Ser Gly Gly Gly Leu Val Gln Ala Gly Gly 
1               5                   10                  15      


Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Ile Thr Phe Arg Asn Lys 
            20                  25                  30          


Ala Ile Gly Trp Tyr Arg Gln Ala Pro Gly Lys Gln Arg Glu Leu Val 
        35                  40                  45              


Ala Arg Ile Asp Ser Tyr Asp Ile Thr Asn Tyr Ala Asp Ser Val Lys 
    50                  55                  60                  


Gly Arg Phe Ser Ile Ser Arg Asp Asn Ser Lys Asn Thr Val Tyr Leu 
65                  70                  75                  80  


Gln Met Asn Ser Leu Lys Ser Glu Asp Thr Ala Val Tyr Tyr Cys Asn 
                85                  90                  95      


Leu Arg Gly Ser Asn Tyr Trp Gly Gln Gly Thr Gln Val Thr Val Ser 
            100                 105                 110         


Ser 
    


<210>  20
<211>  113
<212>  PRT
<213>  Lama glama

<400>  20

Gln Val Gln Leu Gln Glu Ser Gly Gly Gly Leu Val Gln Ala Gly Gly 
1               5                   10                  15      


Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Ile Thr Phe Arg Ser Lys 
            20                  25                  30          


Ser Val Gly Trp Tyr Arg Gln Ala Pro Gly Lys Gln Arg Glu Leu Val 
        35                  40                  45              


Gly Tyr Ile Ser Gly Gly Asp Ile Thr Asp Tyr Thr Asp Ser Val Lys 
    50                  55                  60                  


Gly Arg Phe Ser Ile Ser Arg Asp Asn Ala Lys Asn Thr Val Tyr Leu 
65                  70                  75                  80  


Gln Met Asn Ser Leu Lys Ser Glu Asp Thr Ala Val Tyr Tyr Cys Asn 
                85                  90                  95      


Leu Arg Gly Ser Asn Tyr Trp Gly Gln Gly Thr Gln Val Thr Val Ser 
            100                 105                 110         


Ser 
    


<210>  21
<211>  113
<212>  PRT
<213>  Lama glama

<400>  21

Gln Val Gln Leu Gln Glu Ser Gly Gly Gly Leu Val Gln Ala Gly Gly 
1               5                   10                  15      


Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Ile Thr Phe Arg Gly Lys 
            20                  25                  30          


Ser Val Gly Trp Tyr Arg Gln Ala Pro Gly Lys Gln Arg Glu Leu Val 
        35                  40                  45              


Gly Tyr Met Ser Gly Gly Glu Ile Thr Asp Tyr Ala Asp Ser Val Lys 
    50                  55                  60                  


Gly Arg Phe Ser Ile Ser Arg Asp Asn Ala Lys Asn Thr Val Tyr Leu 
65                  70                  75                  80  


Gln Met Asn Ser Leu Lys Ser Glu Asp Thr Ala Val Tyr Tyr Cys Asn 
                85                  90                  95      


Leu Arg Gly Ser Asn Tyr Trp Gly Gln Gly Thr Gln Val Thr Val Ser 
            100                 105                 110         


Ser 
    


<210>  22
<211>  113
<212>  PRT
<213>  Lama glama

<400>  22

Gln Val Gln Leu Gln Glu Ser Gly Gly Gly Leu Val Gln Ala Gly Gly 
1               5                   10                  15      


Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Ile Thr Phe Arg Ser Lys 
            20                  25                  30          


Ser Val Gly Trp Tyr Arg Gln His Pro Gly Lys Gln Arg Glu Leu Val 
        35                  40                  45              


Gly Tyr Ile Ser Gly Ala Asp Asn Ile Glu Tyr Ala Asp Ser Val Lys 
    50                  55                  60                  


Gly Arg Phe Ser Ile Ser Arg Asp Asn Ala Lys Asn Thr Val Tyr Leu 
65                  70                  75                  80  


Gln Met Asn Ser Leu Lys Ser Glu Asp Thr Ala Val Tyr Tyr Cys Asn 
                85                  90                  95      


Leu Arg Gly Ser Asn Tyr Trp Gly Gln Gly Thr Gln Val Thr Val Ser 
            100                 105                 110         


Ser 
    


<210>  23
<211>  113
<212>  PRT
<213>  Lama glama

<400>  23

Gln Val Gln Leu Gln Glu Ser Gly Gly Gly Leu Val Gln Ala Gly Gly 
1               5                   10                  15      


Phe Leu Arg Leu Ser Cys Ala Ala Ser Gly Ile Thr Phe Arg Ser Lys 
            20                  25                  30          


Ser Val Gly Trp Tyr Arg Gln Ala Pro Gly Lys Gln Arg Glu Leu Val 
        35                  40                  45              


Ala Tyr Ile Ser Gly Asp Asp Ile Thr Asn Tyr Ala Asp Ser Val Lys 
    50                  55                  60                  


Gly Arg Phe Ser Ile Ser Arg Asp Asn Ala Lys Asn Thr Val Tyr Leu 
65                  70                  75                  80  


Gln Met Asn Ser Leu Lys Ser Glu Asp Thr Ala Val Tyr Tyr Cys Asn 
                85                  90                  95      


Leu Arg Gly Ser Asn Tyr Trp Gly Gln Gly Thr Gln Val Thr Val Ser 
            100                 105                 110         


Ser 
    


<210>  24
<211>  113
<212>  PRT
<213>  Lama glama

<400>  24

Gln Val Gln Leu Gln Glu Ser Gly Gly Gly Leu Val Gln Pro Gly Gly 
1               5                   10                  15      


Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Ile Ile Phe Lys Ser Lys 
            20                  25                  30          


Ala Val Gly Trp Tyr Arg Gln Ala Pro Gly Thr Gln Arg Glu Trp Val 
        35                  40                  45              


Ala Tyr Ile Thr Gly Asp Asp Ser Thr Ser Tyr Gln Asp Phe Val Lys 
    50                  55                  60                  


Gly Arg Phe Thr Ile Ser Arg Asp Asn Ala Lys Asn Thr Val Tyr Leu 
65                  70                  75                  80  


Gln Met Asn Asn Leu Lys Pro Glu Asp Thr Ala Val Tyr Tyr Cys Asn 
                85                  90                  95      


Leu Arg Gly Ser Asn Tyr Trp Gly Gln Gly Thr Gln Val Thr Val Ser 
            100                 105                 110         


Ser 
    


<210>  25
<211>  113
<212>  PRT
<213>  Lama glama

<400>  25

Gln Val Gln Leu Gln Glu Ser Gly Gly Gly Leu Val Gln Pro Gly Gly 
1               5                   10                  15      


Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Ile Leu Phe Arg Ser Lys 
            20                  25                  30          


Ala Val Gly Trp Tyr Arg Gln Ala Pro Gly Thr Gln Arg Glu Trp Val 
        35                  40                  45              


Ala Tyr Ile Thr Gly Asp Asp Leu Thr Ser Tyr Glu Asp Phe Val Lys 
    50                  55                  60                  


Gly Arg Phe Thr Ile Ser Arg Asp Asn Ala Lys Asn Met Val Tyr Leu 
65                  70                  75                  80  


Gln Met Asn Ser Leu Lys Pro Glu Asp Thr Ala Val Tyr Tyr Cys Asn 
                85                  90                  95      


Leu Arg Gly Ser Asn Tyr Trp Gly Gln Gly Thr Gln Val Thr Val Ser 
            100                 105                 110         


Ser 
    


<210>  26
<211>  113
<212>  PRT
<213>  Lama glama

<400>  26

Gln Val Gln Leu Gln Glu Ser Gly Gly Gly Leu Val Gln Ala Gly Gly 
1               5                   10                  15      


Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Ile Ile Phe Arg Asn Lys 
            20                  25                  30          


Ala Ile Gly Trp Tyr Arg Gln Ala Pro Gly Lys Gln Arg Glu Leu Val 
        35                  40                  45              


Ala Arg Ile Asp Ser Ala Asp Ile Thr Asn Tyr Pro Asp Ser Val Lys 
    50                  55                  60                  


Gly Arg Phe Ser Ile Ser Arg Asp Asn Ala Lys Asn Thr Val Tyr Leu 
65                  70                  75                  80  


Gln Met Asn Ser Leu Lys Ser Glu Asp Thr Ala Val Tyr Tyr Cys Asn 
                85                  90                  95      


Leu Arg Gly Thr Asn Tyr Trp Gly Gln Gly Thr Gln Val Thr Val Ser 
            100                 105                 110         


Ser 
    


<210>  27
<211>  113
<212>  PRT
<213>  Lama glama

<400>  27

Gln Val Gln Leu Gln Glu Ser Gly Gly Gly Leu Val Gln Ala Gly Gly 
1               5                   10                  15      


Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Ile Ile Phe Arg Asn Lys 
            20                  25                  30          


Ala Ile Gly Trp Tyr Arg Gln Ala Pro Gly Lys Gln Arg Glu Leu Val 
        35                  40                  45              


Ala Arg Ile Asp Ser Ala Asp Ile Thr Asn Tyr Pro Asp Ser Val Lys 
    50                  55                  60                  


Gly Arg Phe Ser Ile Ser Arg Asp Asn Ala Lys Asn Thr Val Tyr Leu 
65                  70                  75                  80  


Gln Met Asn Ser Leu Lys Ser Glu Asp Thr Ala Val Tyr Tyr Cys Asn 
                85                  90                  95      


Leu Arg Gly Thr Asn Tyr Trp Gly Gln Gly Thr Gln Val Thr Val Ser 
            100                 105                 110         


Ser 
    


<210>  28
<211>  113
<212>  PRT
<213>  Lama glama

<400>  28

Gln Val Gln Leu Gln Glu Ser Gly Gly Gly Leu Val Gln Ala Gly Gly 
1               5                   10                  15      


Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Ile Ile Phe Arg Gly Lys 
            20                  25                  30          


Ala Ile Gly Trp Tyr Arg Gln Ala Pro Gly Lys Gln Arg Glu Leu Val 
        35                  40                  45              


Ala Arg Ile Asp Ala Gly Asp Ile Thr Asn Tyr Ala Asp Ser Val Lys 
    50                  55                  60                  


Gly Arg Phe Ser Ile Ser Arg Asp His Ala Lys Asn Thr Val Tyr Leu 
65                  70                  75                  80  


Gln Met Asn Ser Leu Lys Ser Glu Asp Thr Ala Val Tyr Tyr Cys Asn 
                85                  90                  95      


Leu Arg Gly Thr Asn Tyr Trp Gly Gln Gly Thr Gln Val Thr Val Ser 
            100                 105                 110         


Ser 
    


<210>  29
<211>  113
<212>  PRT
<213>  Lama glama

<400>  29

Gln Val Gln Leu Gln Glu Ser Gly Gly Gly Leu Val Gln Ala Gly Gly 
1               5                   10                  15      


Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Ile Thr Phe Arg Arg Lys 
            20                  25                  30          


Ala Val Gly Trp Tyr Arg Gln Ala Pro Gly Lys Gln Arg Glu Leu Val 
        35                  40                  45              


Ala Arg Ile Asp Ser Asp Asp Ile Thr Asn Tyr Ala Asp Ser Val Lys 
    50                  55                  60                  


Gly Arg Phe Ser Ile Ser Arg Asp His Ala Lys Asn Thr Val Tyr Leu 
65                  70                  75                  80  


Gln Met Asn Ser Leu Lys Ser Glu Asp Thr Ala Val Tyr Tyr Cys Asn 
                85                  90                  95      


Leu Arg Gly Thr Asn Tyr Trp Gly Gln Gly Thr Gln Val Thr Val Ser 
            100                 105                 110         


Ser 
    


<210>  30
<211>  113
<212>  PRT
<213>  Lama glama

<400>  30

Gln Val Gln Leu Gln Glu Ser Gly Gly Gly Leu Val Gln Ala Gly Gly 
1               5                   10                  15      


Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Ile Thr Leu Arg Asn Lys 
            20                  25                  30          


Ser Val Gly Trp Tyr Arg Gln Ala Pro Gly Arg Gln Arg Glu Leu Val 
        35                  40                  45              


Gly Tyr Ile Ser Gly Asp Asp Ile Thr Asn Tyr Val Asp Ser Val Lys 
    50                  55                  60                  


Ala Arg Phe Ser Ile Ser Arg Asp Asn Ala Lys Asn Thr Val Tyr Leu 
65                  70                  75                  80  


Gln Met Asn Ser Leu Lys Ser Glu Asp Thr Ala Val Tyr Tyr Cys Asn 
                85                  90                  95      


Leu Arg Gly Ala Asn Tyr Trp Gly Gln Gly Thr Gln Val Thr Val Ser 
            100                 105                 110         


Ser 
    


<210>  31
<211>  113
<212>  PRT
<213>  Lama glama

<400>  31

Gln Val Gln Leu Gln Glu Ser Gly Gly Gly Leu Val Gln Ala Gly Gly 
1               5                   10                  15      


Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Ile Thr Leu Arg Asn Lys 
            20                  25                  30          


Ser Val Gly Trp Tyr Arg Gln Ala Pro Gly Arg Gln Arg Glu Leu Val 
        35                  40                  45              


Gly Tyr Ile Ser Gly Asp Asp Ile Thr Asn Tyr Val Asp Ser Val Lys 
    50                  55                  60                  


Ala Arg Phe Ser Ile Ser Arg Asp Asn Ala Lys Asn Thr Val Tyr Leu 
65                  70                  75                  80  


Gln Met Asn Ser Leu Lys Ser Glu Asp Thr Ala Val Tyr Tyr Cys Asn 
                85                  90                  95      


Leu Arg Gly Ala Asn Tyr Trp Gly Gln Gly Thr Gln Val Thr Val Ser 
            100                 105                 110         


Ser 
    


<210>  32
<211>  118
<212>  PRT
<213>  Lama glama

<400>  32

Gln Val Gln Leu Gln Glu Ser Gly Gly Gly Leu Val Gln Ala Gly Gly 
1               5                   10                  15      


Ser Leu Arg Leu Ser Cys Thr Ala Ser Gly Ser Ile Phe Asn Thr Ala 
            20                  25                  30          


Thr Met Ala Trp Ser Arg Gln Ala Pro Gly Lys Gln Arg Glu Leu Val 
        35                  40                  45              


Ala Ser Ile Thr Gln Gly Arg Ile Thr Tyr Pro Val Asp Ser Val Lys 
    50                  55                  60                  


Gly Arg Phe Thr Leu Ser Arg Asp Asn Ser Lys Asn Thr Val Tyr Leu 
65                  70                  75                  80  


Gln Met Asn Ser Leu Glu Pro Glu Asp Thr Ala Val Tyr Tyr Cys Gly 
                85                  90                  95      


Val Asp Thr Ile Pro Thr Ser Arg Pro Arg Tyr Trp Gly Gln Gly Thr 
            100                 105                 110         


Gln Val Thr Val Ser Ser 
        115             


<210>  33
<211>  116
<212>  PRT
<213>  Lama glama

<400>  33

Gln Val Gln Leu Gln Glu Ser Gly Gly Gly Leu Val Gln Ala Gly Gly 
1               5                   10                  15      


Ser Leu Arg Leu Ser Cys Ala Ala Ser Glu Asn Pro Ser Ser Ile Ser 
            20                  25                  30          


Thr Met Ala Trp Tyr Arg Gln Ala Pro Gly Lys Gln Arg Glu Leu Val 
        35                  40                  45              


Ala Arg Ile Ile Thr Gly Gly Tyr Thr Asn Tyr Leu Asp Ser Val Met 
    50                  55                  60                  


Gly Arg Phe Thr Ile Ser Arg Gly Asn Arg Glu Ser Thr Ala Tyr Leu 
65                  70                  75                  80  


Gln Met Asn Ser Leu Lys Pro Glu Asp Thr Ala Val Tyr Ile Cys Asn 
                85                  90                  95      


Ala Arg Thr Trp Ser Ser Ala Asp Tyr Trp Gly Gln Gly Thr Gln Val 
            100                 105                 110         


Thr Val Ser Ser 
        115     


<210>  34
<211>  128
<212>  PRT
<213>  Lama glama

<400>  34

Gln Val Gln Leu Gln Glu Ser Gly Gly Gly Leu Val Gln Ala Gly Gly 
1               5                   10                  15      


Ser Leu Arg Leu Ser Cys Ala Val Ser Gly Arg Thr Gly Asn Ile Tyr 
            20                  25                  30          


Ala Ala Met Gly Trp Phe Arg Gln Ala Pro Gly Lys Gln Arg Glu Phe 
        35                  40                  45              


Val Ser Ala Asp Ser Trp Asn Ala Gly Thr Thr Asp Tyr Ala Asp Ser 
    50                  55                  60                  


Val Lys Gly Arg Phe Thr Ile Ser Arg Asp Asn Ala Lys Ser Thr Val 
65                  70                  75                  80  


Tyr Leu Gln Met Asn Ser Leu Lys Pro Glu Asp Thr Ala Val Tyr Tyr 
                85                  90                  95      


Cys Ala Ala Lys Ile Gly Leu Tyr Asp Thr Ser Arg Gly Arg Phe Glu 
            100                 105                 110         


Asn Glu Tyr Asp Tyr Trp Gly Gln Gly Thr Gln Val Thr Val Ser Ser 
        115                 120                 125             


<210>  35
<211>  126
<212>  PRT
<213>  Lama glama

<400>  35

Gln Val Gln Leu Gln Glu Ser Gly Gly Gly Leu Val Gln Ala Gly Gly 
1               5                   10                  15      


Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Arg Thr Gly Asn Ile Tyr 
            20                  25                  30          


Ala Ala Met Gly Trp Phe Arg Gln Ala Pro Gly Lys Gln Arg Glu Phe 
        35                  40                  45              


Val Ser Ser Asp Ser Trp Asn Gly Gly Ser Thr Asp Tyr Ala Asp Ser 
    50                  55                  60                  


Val Lys Gly Arg Phe Thr Ile Ser Arg Asp Asn Ala Lys Ser Thr Val 
65                  70                  75                  80  


Tyr Leu Gln Met Asn Ser Leu Lys Pro Glu Asp Thr Ala Val Tyr Tyr 
                85                  90                  95      


Cys Ala Ala Lys Ile Gly Leu His Asp Thr Ser Arg Phe Glu Asn Glu 
            100                 105                 110         


Tyr Asp Tyr Trp Gly Gln Gly Thr Gln Val Thr Val Ser Ser 
        115                 120                 125     


<210>  36
<211>  125
<212>  PRT
<213>  Lama glama

<400>  36

Gln Val Gln Leu Gln Glu Ser Gly Gly Gly Leu Val Gln Ala Gly Gly 
1               5                   10                  15      


Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Arg Thr Asp Ile Tyr Ala 
            20                  25                  30          


Ala Met Gly Trp Phe Arg Gln Ala Pro Gly Lys Gln Arg Glu Phe Val 
        35                  40                  45              


Ala Ser Asp Ser Trp Asn Gly Gly Ser Thr Asp Tyr Ala Asp Ser Val 
    50                  55                  60                  


Lys Gly Arg Phe Thr Ile Ser Arg Asp Asn Ala Lys Ser Thr Val Asn 
65                  70                  75                  80  


Leu Gln Met Asn Ser Leu Lys Pro Glu Asp Thr Ala Val Tyr Val Cys 
                85                  90                  95      


Ala Ala Lys Ile Gly Leu Tyr Gly Thr Thr Arg Phe Glu Asn Glu Tyr 
            100                 105                 110         


Asp Tyr Trp Gly Gln Gly Thr Gln Val Thr Val Ser Ser 
        115                 120                 125 


<210>  37
<211>  126
<212>  PRT
<213>  Lama glama

<400>  37

Gln Val Gln Leu Gln Glu Ser Gly Gly Gly Leu Val Gln Ala Gly Gly 
1               5                   10                  15      


Ser Leu Arg Leu Ser Cys Ala Val Ser Gly Arg Thr Gly Ser Ile Tyr 
            20                  25                  30          


Ala Ala Met Gly Trp Phe Arg Gln Ala Pro Gly Lys Gln Arg Glu Phe 
        35                  40                  45              


Val Ala Ser Asp Ser Trp Asn Ala Leu Ser Thr Asp Tyr Gly Asp Ser 
    50                  55                  60                  


Val Lys Gly Arg Phe Thr Ile Ser Arg Asp Asn Ala Lys Asn Thr Val 
65                  70                  75                  80  


Tyr Leu Gln Met Thr Thr Leu Lys Pro Glu Asp Thr Ala Val Tyr Tyr 
                85                  90                  95      


Cys Ala Ala Lys Ile Gly Leu Tyr Gly Thr Thr Arg Phe Glu Asn Glu 
            100                 105                 110         


Tyr Asp Tyr Trp Gly Gln Gly Thr Gln Val Thr Val Ser Ser 
        115                 120                 125     


<210>  38
<211>  125
<212>  PRT
<213>  Lama glama

<400>  38

Gln Val Gln Leu Gln Glu Ser Gly Gly Gly Leu Val Gln Ala Gly Gly 
1               5                   10                  15      


Ser Leu Arg Leu Asp Cys Ala Ala Ser Ala Arg Thr Ser Ile Tyr Ala 
            20                  25                  30          


Thr Val Gly Trp Phe Arg Gln Val Pro Gly Lys Gln Arg Glu Phe Val 
        35                  40                  45              


Ser Ser Val Ser Trp Asn Gly Gly Ser Thr Asp Tyr Thr Asp Ser Val 
    50                  55                  60                  


Lys Gly Arg Phe Thr Ile Ser Arg Asp Asn Ala Lys Asn Thr Val Val 
65                  70                  75                  80  


Leu Gln Met Asn Ser Leu Lys Pro Glu Asp Thr Ala Val Tyr Tyr Cys 
                85                  90                  95      


Ala Ala Lys Ile Gly Leu Tyr Gly Thr Arg Arg Phe Glu Thr Asp Tyr 
            100                 105                 110         


Asp Tyr Trp Gly Gln Gly Thr Gln Val Thr Val Ser Ser 
        115                 120                 125 


<210>  39
<211>  121
<212>  PRT
<213>  Lama glama

<400>  39

Gln Val Gln Leu Gln Glu Ser Gly Gly Gly Leu Ala Gln Ala Gly Gly 
1               5                   10                  15      


Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Phe Asp Phe Asp Tyr Tyr 
            20                  25                  30          


Ala Ile Gly Trp Phe Arg Gln Ala Pro Gly Lys Glu Arg Glu Gly Val 
        35                  40                  45              


Ala Cys Ile Thr Asp Ser Asp Gly Ser Thr Ile Tyr Ala Asp Ser Val 
    50                  55                  60                  


Arg Gly Arg Phe Thr Ile Thr Ala Asp Asn Ala Glu Asn Thr Val Tyr 
65                  70                  75                  80  


Leu Gln Met Asn Ser Leu Lys Pro Glu Asp Thr Ala Glu Tyr Phe Cys 
                85                  90                  95      


Ala Ala Glu Cys Phe Ala Cys Ser Gly Tyr Ala Cys His Ser Trp Gly 
            100                 105                 110         


Arg Gly Thr Gln Val Thr Val Ser Ser 
        115                 120     


<210>  40
<211>  124
<212>  PRT
<213>  Lama glama

<400>  40

Gln Val Gln Leu Gln Glu Ser Gly Gly Gly Leu Val Gln Pro Gly Gly 
1               5                   10                  15      


Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Phe Thr Ile Asp Tyr Tyr 
            20                  25                  30          


Ala Ile Ala Trp Phe Arg Gln Ala Pro Gly Glu Glu Arg Glu Trp Val 
        35                  40                  45              


Ser Cys Ile Arg Ser Gly Asp Gly Ser Thr Trp Tyr Val Asp Ser Val 
    50                  55                  60                  


Lys Gly Arg Phe Ser Ile Ser Ser Asp Asn Ala Lys Asn Ala Val Tyr 
65                  70                  75                  80  


Leu Gln Ile Ser Ser Leu Lys Pro Glu Asp Thr Ala Val Tyr Tyr Cys 
                85                  90                  95      


Ala Ala Ser Arg Gly Ser Pro Tyr Cys Pro Ala Val Ile Asp Tyr Asp 
            100                 105                 110         


Tyr Trp Gly Gln Gly Thr Gln Val Thr Val Ser Ser 
        115                 120                 


<210>  41
<211>  126
<212>  PRT
<213>  Lama glama

<400>  41

Gln Val Gln Leu Gln Glu Ser Gly Gly Gly Leu Val Gln Pro Gly Gly 
1               5                   10                  15      


Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Ile Ile Phe Arg Ser Lys 
            20                  25                  30          


Ser Val Gly Trp Tyr Arg Gln Ala Pro Gly Thr Gln Arg Glu Trp Val 
        35                  40                  45              


Ala Tyr Ile Ser Gly Asp Asp Ser Thr Asn Tyr Glu Asp Phe Val Lys 
    50                  55                  60                  


Gly Arg Phe Thr Ile Ser Arg Asp Asn Ala Lys Asn Thr Val Tyr Leu 
65                  70                  75                  80  


Gln Met Asn Ser Val Lys Pro Glu Asp Thr Ala Ile Tyr Tyr Cys Ala 
                85                  90                  95      


Ala Asp Tyr Arg Asp Tyr Asp Glu Leu Leu Leu Pro Val Pro Pro Pro 
            100                 105                 110         


Tyr Asp Tyr Trp Gly Gln Gly Thr Gln Val Thr Val Ser Ser 
        115                 120                 125     


<210>  42
<211>  124
<212>  PRT
<213>  Lama glama

<400>  42

Gln Val Gln Leu Gln Glu Ser Gly Gly Gly Leu Val Gln Ala Gly Gly 
1               5                   10                  15      


Ser Leu Arg Leu Ser Cys Val Val Ser Gly Gly Thr Phe Arg Leu Tyr 
            20                  25                  30          


Gly Ile Gly Trp Phe Arg Gln Ala Pro Gly Lys Asp Arg Glu Phe Val 
        35                  40                  45              


Gly Phe Ile Thr Trp Ser Ser Gly Arg Thr Tyr Tyr Ser Asp Ser Leu 
    50                  55                  60                  


Lys Gly Arg Leu Thr Ile Ser Arg Asp Asn Ala Lys Asn Ser Val Asp 
65                  70                  75                  80  


Leu Gln Met Asn Arg Leu Gln Pro Glu Asp Thr Ala Ile Tyr Tyr Cys 
                85                  90                  95      


Ala Ala Asn Pro Thr Asp Thr Leu Arg Leu Ser Thr Pro Ser Tyr Asn 
            100                 105                 110         


His Trp Gly Gln Gly Thr Gln Val Thr Val Ser Ser 
        115                 120                 


<210>  43
<211>  384
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic construct

<400>  43

Met Ala Gln Val Gln Leu Gln Glu Ser Gly Gly Gly Leu Val Gln Pro 
1               5                   10                  15      


Gly Gly Ser Leu Lys Leu Ala Cys Ala Ala Ser Gly Ile Thr Phe Arg 
            20                  25                  30          


Asn Lys Ala Ile Gly Trp Tyr Arg Gln Ala Pro Gly Lys Gly Arg Glu 
        35                  40                  45              


Leu Val Ala Arg Ile Asp Ser Phe Asp Thr Thr Asp Tyr Ala Asp Ser 
    50                  55                  60                  


Val Lys Gly Arg Phe Ser Ile Ser Arg Asp Asn Ala Lys Asn Thr Val 
65                  70                  75                  80  


Tyr Leu Gln Met Asn Ser Leu Lys Ser Glu Asp Thr Ala Val Tyr Tyr 
                85                  90                  95      


Cys Asn Leu Arg Gly Ser Asn Tyr Trp Gly Gln Gly Thr Gln Val Thr 
            100                 105                 110         


Val Ser Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Gly Gly Gly 
        115                 120                 125             


Gly Ser Gln Val Gln Leu Gln Glu Ser Gly Gly Gly Leu Val Gln Ala 
    130                 135                 140                 


Gly Gly Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Arg Asn Ile Ser 
145                 150                 155                 160 


Glu Tyr Val Met Gly Trp Phe Arg Gln Ala Pro Gly Lys Glu Arg Glu 
                165                 170                 175     


Phe Val Ala Ala Ile Ser Trp Ser Ala Gly Asn Ile Tyr Tyr Ala Asp 
            180                 185                 190         


Ser Val Lys Gly Arg Phe Thr Ile Ser Arg Asp Asn Ala Lys Asn Thr 
        195                 200                 205             


Val His Leu Gln Met Asn Thr Leu Arg Pro Glu Asp Thr Ala Val Tyr 
    210                 215                 220                 


Tyr Cys Ala Ala Gly Arg Tyr Ser Ala Trp Tyr Val Ala Ala Tyr Glu 
225                 230                 235                 240 


Tyr Asp Tyr Trp Gly Gln Gly Thr Gln Val Thr Val Ser Ser Gly Gly 
                245                 250                 255     


Gly Gly Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Gln Val Gln 
            260                 265                 270         


Leu Gln Glu Ser Gly Gly Gly Leu Val Gln Pro Gly Gly Ser Leu Lys 
        275                 280                 285             


Leu Ala Cys Ala Ala Ser Gly Ile Thr Phe Arg Asn Lys Ala Ile Gly 
    290                 295                 300                 


Trp Tyr Arg Gln Ala Pro Gly Lys Gly Arg Glu Leu Val Ala Arg Ile 
305                 310                 315                 320 


Asp Ser Phe Asp Thr Thr Asp Tyr Ala Asp Ser Val Lys Gly Arg Phe 
                325                 330                 335     


Ser Ile Ser Arg Asp Asn Ala Lys Asn Thr Val Tyr Leu Gln Met Asn 
            340                 345                 350         


Ser Leu Lys Ser Glu Asp Thr Ala Val Tyr Tyr Cys Asn Leu Arg Gly 
        355                 360                 365             


Ser Asn Tyr Trp Gly Gln Gly Thr Gln Val Thr Val Ser Ser His His 
    370                 375                 380                 


<210>  44
<211>  380
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic construct

<400>  44

Glu Val Gln Leu Gln Glu Ser Gly Gly Gly Leu Val Gln Pro Gly Gly 
1               5                   10                  15      


Ser Leu Lys Leu Ala Cys Ala Ala Ser Gly Ile Thr Phe Arg Asn Lys 
            20                  25                  30          


Ala Ile Gly Trp Tyr Arg Gln Ala Pro Gly Lys Gly Leu Glu Leu Val 
        35                  40                  45              


Ala Arg Ile Asp Ser Phe Asp Thr Thr Asp Tyr Ala Asp Ser Val Lys 
    50                  55                  60                  


Gly Arg Phe Ser Ile Ser Arg Asp Asn Ser Lys Asn Thr Leu Tyr Leu 
65                  70                  75                  80  


Gln Met Asn Ser Leu Arg Ala Glu Asp Thr Ala Val Tyr Tyr Cys Asn 
                85                  90                  95      


Leu Arg Gly Ser Asn Tyr Trp Gly Gln Gly Thr Leu Val Thr Val Ser 
            100                 105                 110         


Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser 
        115                 120                 125             


Gln Val Gln Leu Gln Glu Ser Gly Gly Gly Leu Val Gln Ala Gly Gly 
    130                 135                 140                 


Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Arg Asn Ile Ser Glu Tyr 
145                 150                 155                 160 


Val Met Gly Trp Phe Arg Gln Ala Pro Gly Lys Glu Arg Glu Phe Val 
                165                 170                 175     


Ala Ala Ile Ser Trp Ser Ala Gly Asn Ile Tyr Tyr Ala Asp Ser Val 
            180                 185                 190         


Lys Gly Arg Phe Thr Ile Ser Arg Asp Asn Ala Lys Asn Thr Val His 
        195                 200                 205             


Leu Gln Met Asn Thr Leu Arg Pro Glu Asp Thr Ala Val Tyr Tyr Cys 
    210                 215                 220                 


Ala Ala Gly Arg Tyr Ser Ala Trp Tyr Val Ala Ala Tyr Glu Tyr Asp 
225                 230                 235                 240 


Tyr Trp Gly Gln Gly Thr Gln Val Thr Val Ser Ser Gly Gly Gly Gly 
                245                 250                 255     


Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Glu Val Gln Leu Gln 
            260                 265                 270         


Glu Ser Gly Gly Gly Leu Val Gln Pro Gly Gly Ser Leu Lys Leu Ala 
        275                 280                 285             


Cys Ala Ala Ser Gly Ile Thr Phe Arg Asn Lys Ala Ile Gly Trp Tyr 
    290                 295                 300                 


Arg Gln Ala Pro Gly Lys Gly Leu Glu Leu Val Ala Arg Ile Asp Ser 
305                 310                 315                 320 


Phe Asp Thr Thr Asp Tyr Ala Asp Ser Val Lys Gly Arg Phe Ser Ile 
                325                 330                 335     


Ser Arg Asp Asn Ser Lys Asn Thr Leu Tyr Leu Gln Met Asn Ser Leu 
            340                 345                 350         


Arg Ala Glu Asp Thr Ala Val Tyr Tyr Cys Asn Leu Arg Gly Ser Asn 
        355                 360                 365             


Tyr Trp Gly Gln Gly Thr Leu Val Thr Val Ser Ser 
    370                 375                 380 


<210>  45
<211>  380
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic construct

<400>  45

Glu Val Gln Leu Gln Glu Ser Gly Gly Gly Leu Val Gln Pro Gly Gly 
1               5                   10                  15      


Ser Leu Lys Leu Ala Cys Ala Ala Ser Gly Ile Thr Phe Arg Asn Lys 
            20                  25                  30          


Ala Ile Gly Trp Tyr Arg Gln Ala Pro Gly Lys Gly Leu Glu Leu Val 
        35                  40                  45              


Ala Arg Ile Asp Ser Phe Asp Thr Thr Asp Tyr Ala Asp Ser Val Lys 
    50                  55                  60                  


Gly Arg Phe Ser Ile Ser Arg Asp Asn Ser Lys Asn Thr Leu Tyr Leu 
65                  70                  75                  80  


Gln Met Asn Ser Leu Arg Ala Glu Asp Thr Ala Val Tyr Tyr Cys Asn 
                85                  90                  95      


Leu Arg Gly Ser Asn Tyr Trp Gly Gln Gly Thr Leu Val Thr Val Ser 
            100                 105                 110         


Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser 
        115                 120                 125             


Gln Val Gln Leu Gln Glu Ser Gly Gly Gly Leu Val Gln Pro Gly Gly 
    130                 135                 140                 


Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Arg Asn Ile Ser Glu Tyr 
145                 150                 155                 160 


Val Met Gly Trp Phe Arg Gln Ala Pro Gly Lys Gly Leu Glu Phe Val 
                165                 170                 175     


Ala Ala Ile Ser Trp Ser Ala Gly Asn Ile Tyr Tyr Ala Asp Ser Val 
            180                 185                 190         


Lys Gly Arg Phe Thr Ile Ser Arg Asp Asn Ser Lys Asn Thr Leu Tyr 
        195                 200                 205             


Leu Gln Met Asn Ser Leu Arg Ala Glu Asp Thr Ala Val Tyr Tyr Cys 
    210                 215                 220                 


Ala Ala Gly Arg Tyr Ser Ala Trp Tyr Val Ala Ala Tyr Glu Tyr Asp 
225                 230                 235                 240 


Tyr Trp Gly Gln Gly Thr Leu Val Thr Val Ser Ser Gly Gly Gly Gly 
                245                 250                 255     


Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Glu Val Gln Leu Gln 
            260                 265                 270         


Glu Ser Gly Gly Gly Leu Val Gln Pro Gly Gly Ser Leu Lys Leu Ala 
        275                 280                 285             


Cys Ala Ala Ser Gly Ile Thr Phe Arg Asn Lys Ala Ile Gly Trp Tyr 
    290                 295                 300                 


Arg Gln Ala Pro Gly Lys Gly Leu Glu Leu Val Ala Arg Ile Asp Ser 
305                 310                 315                 320 


Phe Asp Thr Thr Asp Tyr Ala Asp Ser Val Lys Gly Arg Phe Ser Ile 
                325                 330                 335     


Ser Arg Asp Asn Ser Lys Asn Thr Leu Tyr Leu Gln Met Asn Ser Leu 
            340                 345                 350         


Arg Ala Glu Asp Thr Ala Val Tyr Tyr Cys Asn Leu Arg Gly Ser Asn 
        355                 360                 365             


Tyr Trp Gly Gln Gly Thr Leu Val Thr Val Ser Ser 
    370                 375                 380 


<210>  46
<211>  380
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic construct

<400>  46

Glu Val Gln Leu Gln Glu Ser Gly Gly Gly Leu Val Gln Pro Gly Gly 
1               5                   10                  15      


Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Ile Thr Phe Arg Asn Lys 
            20                  25                  30          


Ala Ile Gly Trp Tyr Arg Gln Ala Pro Gly Lys Gly Leu Glu Leu Val 
        35                  40                  45              


Ala Arg Ile Asp Ser Phe Asp Thr Thr Asp Tyr Ala Asp Ser Val Lys 
    50                  55                  60                  


Gly Arg Phe Thr Ile Ser Arg Asp Asn Ser Lys Asn Thr Leu Tyr Leu 
65                  70                  75                  80  


Gln Met Asn Ser Leu Arg Ala Glu Asp Thr Ala Val Tyr Tyr Cys Asn 
                85                  90                  95      


Leu Arg Gly Ser Asn Tyr Trp Gly Gln Gly Thr Leu Val Thr Val Ser 
            100                 105                 110         


Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser 
        115                 120                 125             


Gln Val Gln Leu Gln Glu Ser Gly Gly Gly Leu Val Gln Ala Gly Gly 
    130                 135                 140                 


Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Arg Asn Ile Ser Glu Tyr 
145                 150                 155                 160 


Val Met Gly Trp Phe Arg Gln Ala Pro Gly Lys Glu Arg Glu Phe Val 
                165                 170                 175     


Ala Ala Ile Ser Trp Ser Ala Gly Asn Ile Tyr Tyr Ala Asp Ser Val 
            180                 185                 190         


Lys Gly Arg Phe Thr Ile Ser Arg Asp Asn Ala Lys Asn Thr Val His 
        195                 200                 205             


Leu Gln Met Asn Thr Leu Arg Pro Glu Asp Thr Ala Val Tyr Tyr Cys 
    210                 215                 220                 


Ala Ala Gly Arg Tyr Ser Ala Trp Tyr Val Ala Ala Tyr Glu Tyr Asp 
225                 230                 235                 240 


Tyr Trp Gly Gln Gly Thr Gln Val Thr Val Ser Ser Gly Gly Gly Gly 
                245                 250                 255     


Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Glu Val Gln Leu Gln 
            260                 265                 270         


Glu Ser Gly Gly Gly Leu Val Gln Pro Gly Gly Ser Leu Arg Leu Ser 
        275                 280                 285             


Cys Ala Ala Ser Gly Ile Thr Phe Arg Asn Lys Ala Ile Gly Trp Tyr 
    290                 295                 300                 


Arg Gln Ala Pro Gly Lys Gly Leu Glu Leu Val Ala Arg Ile Asp Ser 
305                 310                 315                 320 


Phe Asp Thr Thr Asp Tyr Ala Asp Ser Val Lys Gly Arg Phe Thr Ile 
                325                 330                 335     


Ser Arg Asp Asn Ser Lys Asn Thr Leu Tyr Leu Gln Met Asn Ser Leu 
            340                 345                 350         


Arg Ala Glu Asp Thr Ala Val Tyr Tyr Cys Asn Leu Arg Gly Ser Asn 
        355                 360                 365             


Tyr Trp Gly Gln Gly Thr Leu Val Thr Val Ser Ser 
    370                 375                 380 


<210>  47
<211>  380
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic construct

<400>  47

Glu Val Gln Leu Gln Glu Ser Gly Gly Gly Leu Val Gln Pro Gly Gly 
1               5                   10                  15      


Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Ile Thr Phe Arg Asn Lys 
            20                  25                  30          


Ala Ile Gly Trp Tyr Arg Gln Ala Pro Gly Lys Gly Leu Glu Leu Val 
        35                  40                  45              


Ala Arg Ile Asp Ser Phe Asp Thr Thr Asp Tyr Ala Asp Ser Val Lys 
    50                  55                  60                  


Gly Arg Phe Thr Ile Ser Arg Asp Asn Ser Lys Asn Thr Leu Tyr Leu 
65                  70                  75                  80  


Gln Met Asn Ser Leu Arg Ala Glu Asp Thr Ala Val Tyr Tyr Cys Asn 
                85                  90                  95      


Leu Arg Gly Ser Asn Tyr Trp Gly Gln Gly Thr Leu Val Thr Val Ser 
            100                 105                 110         


Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser 
        115                 120                 125             


Gln Val Gln Leu Gln Glu Ser Gly Gly Gly Leu Val Gln Pro Gly Gly 
    130                 135                 140                 


Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Arg Asn Ile Ser Glu Tyr 
145                 150                 155                 160 


Val Met Gly Trp Phe Arg Gln Ala Pro Gly Lys Gly Leu Glu Phe Val 
                165                 170                 175     


Ala Ala Ile Ser Trp Ser Ala Gly Asn Ile Tyr Tyr Ala Asp Ser Val 
            180                 185                 190         


Lys Gly Arg Phe Thr Ile Ser Arg Asp Asn Ser Lys Asn Thr Leu Tyr 
        195                 200                 205             


Leu Gln Met Asn Ser Leu Arg Ala Glu Asp Thr Ala Val Tyr Tyr Cys 
    210                 215                 220                 


Ala Ala Gly Arg Tyr Ser Ala Trp Tyr Val Ala Ala Tyr Glu Tyr Asp 
225                 230                 235                 240 


Tyr Trp Gly Gln Gly Thr Leu Val Thr Val Ser Ser Gly Gly Gly Gly 
                245                 250                 255     


Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Glu Val Gln Leu Gln 
            260                 265                 270         


Glu Ser Gly Gly Gly Leu Val Gln Pro Gly Gly Ser Leu Arg Leu Ser 
        275                 280                 285             


Cys Ala Ala Ser Gly Ile Thr Phe Arg Asn Lys Ala Ile Gly Trp Tyr 
    290                 295                 300                 


Arg Gln Ala Pro Gly Lys Gly Leu Glu Leu Val Ala Arg Ile Asp Ser 
305                 310                 315                 320 


Phe Asp Thr Thr Asp Tyr Ala Asp Ser Val Lys Gly Arg Phe Thr Ile 
                325                 330                 335     


Ser Arg Asp Asn Ser Lys Asn Thr Leu Tyr Leu Gln Met Asn Ser Leu 
            340                 345                 350         


Arg Ala Glu Asp Thr Ala Val Tyr Tyr Cys Asn Leu Arg Gly Ser Asn 
        355                 360                 365             


Tyr Trp Gly Gln Gly Thr Leu Val Thr Val Ser Ser 
    370                 375                 380 


<210>  48
<211>  30
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic primer

<400>  48
atcaacatgc atgcggattg tgctaaaggt                                        30


<210>  49
<211>  60
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic primer

<400>  49
taaaatctta agagaaccag aaccagaacc agaaccagaa ccgtcattat taaactgcac       60


<210>  50
<211>  33
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic primer

<400>  50
gtttaagaat tcgaaggaga taccaccatg cat                                    33


<210>  51
<211>  37
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic primer

<400>  51
cgtagcgcga acagactcga tcgtactgac cacctgt                                37


<210>  52
<211>  30
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic primer

<400>  52
gatgtgcagc tgcaggagtc tggagggagg                                        30


<210>  53
<211>  30
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic primer

<400>  53
gatgtgcagc tgcaggagtc tggagggagg                                        30


<210>  54
<211>  5
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic peptide

<400>  54

Gly Gly Gly Gly Ser 
1               5   


