                         LISTADO DE SECUENCIAS

<110>  Servicio Andaluz de Salud
<110>  Universidad de Crdoba
 
<120>  Polimorfismos de la enzima convertidora de angiotensina para 
       predecir o pronosticar la respuesta al tratamiento 
       antiangiognico del cncer.

<130>  PCT-06858

<160>  8     

<170>  PatentIn version 3.5

<210>  1
<211>  50
<212>  DNA
<213>  Homo sapiens

<400>  1
atacagtcac tttttttttt tttttgagac ggagtctcgc tctgtcgccc                  50


<210>  2
<211>  100
<212>  DNA
<213>  Homo sapiens

<400>  2
tcccatttct ctagacctgc tgcctataca gtcacttttt tttttttttt gagacggagt       60

ctcgctctgt cgcccataca gtcactttta tgtggtttcg                            100


<210>  3
<211>  1306
<212>  PRT
<213>  Homo sapiens

<400>  3

Met Gly Ala Ala Ser Gly Arg Arg Gly Pro Gly Leu Leu Leu Pro Leu 
1               5                   10                  15      


Pro Leu Leu Leu Leu Leu Pro Pro Gln Pro Ala Leu Ala Leu Asp Pro 
            20                  25                  30          


Gly Leu Gln Pro Gly Asn Phe Ser Ala Asp Glu Ala Gly Ala Gln Leu 
        35                  40                  45              


Phe Ala Gln Ser Tyr Asn Ser Ser Ala Glu Gln Val Leu Phe Gln Ser 
    50                  55                  60                  


Val Ala Ala Ser Trp Ala His Asp Thr Asn Ile Thr Ala Glu Asn Ala 
65                  70                  75                  80  


Arg Arg Gln Glu Glu Ala Ala Leu Leu Ser Gln Glu Phe Ala Glu Ala 
                85                  90                  95      


Trp Gly Gln Lys Ala Lys Glu Leu Tyr Glu Pro Ile Trp Gln Asn Phe 
            100                 105                 110         


Thr Asp Pro Gln Leu Arg Arg Ile Ile Gly Ala Val Arg Thr Leu Gly 
        115                 120                 125             


Ser Ala Asn Leu Pro Leu Ala Lys Arg Gln Gln Tyr Asn Ala Leu Leu 
    130                 135                 140                 


Ser Asn Met Ser Arg Ile Tyr Ser Thr Ala Lys Val Cys Leu Pro Asn 
145                 150                 155                 160 


Lys Thr Ala Thr Cys Trp Ser Leu Asp Pro Asp Leu Thr Asn Ile Leu 
                165                 170                 175     


Ala Ser Ser Arg Ser Tyr Ala Met Leu Leu Phe Ala Trp Glu Gly Trp 
            180                 185                 190         


His Asn Ala Ala Gly Ile Pro Leu Lys Pro Leu Tyr Glu Asp Phe Thr 
        195                 200                 205             


Ala Leu Ser Asn Glu Ala Tyr Lys Gln Asp Gly Phe Thr Asp Thr Gly 
    210                 215                 220                 


Ala Tyr Trp Arg Ser Trp Tyr Asn Ser Pro Thr Phe Glu Asp Asp Leu 
225                 230                 235                 240 


Glu His Leu Tyr Gln Gln Leu Glu Pro Leu Tyr Leu Asn Leu His Ala 
                245                 250                 255     


Phe Val Arg Arg Ala Leu His Arg Arg Tyr Gly Asp Arg Tyr Ile Asn 
            260                 265                 270         


Leu Arg Gly Pro Ile Pro Ala His Leu Leu Gly Asp Met Trp Ala Gln 
        275                 280                 285             


Ser Trp Glu Asn Ile Tyr Asp Met Val Val Pro Phe Pro Asp Lys Pro 
    290                 295                 300                 


Asn Leu Asp Val Thr Ser Thr Met Leu Gln Gln Gly Trp Asn Ala Thr 
305                 310                 315                 320 


His Met Phe Arg Val Ala Glu Glu Phe Phe Thr Ser Leu Glu Leu Ser 
                325                 330                 335     


Pro Met Pro Pro Glu Phe Trp Glu Gly Ser Met Leu Glu Lys Pro Ala 
            340                 345                 350         


Asp Gly Arg Glu Val Val Cys His Ala Ser Ala Trp Asp Phe Tyr Asn 
        355                 360                 365             


Arg Lys Asp Phe Arg Ile Lys Gln Cys Thr Arg Val Thr Met Asp Gln 
    370                 375                 380                 


Leu Ser Thr Val His His Glu Met Gly His Ile Gln Tyr Tyr Leu Gln 
385                 390                 395                 400 


Tyr Lys Asp Leu Pro Val Ser Leu Arg Arg Gly Ala Asn Pro Gly Phe 
                405                 410                 415     


His Glu Ala Ile Gly Asp Val Leu Ala Leu Ser Val Ser Thr Pro Glu 
            420                 425                 430         


His Leu His Lys Ile Gly Leu Leu Asp Arg Val Thr Asn Asp Thr Glu 
        435                 440                 445             


Ser Asp Ile Asn Tyr Leu Leu Lys Met Ala Leu Glu Lys Ile Ala Phe 
    450                 455                 460                 


Leu Pro Phe Gly Tyr Leu Val Asp Gln Trp Arg Trp Gly Val Phe Ser 
465                 470                 475                 480 


Gly Arg Thr Pro Pro Ser Arg Tyr Asn Phe Asp Trp Trp Tyr Leu Arg 
                485                 490                 495     


Thr Lys Tyr Gln Gly Ile Cys Pro Pro Val Thr Arg Asn Glu Thr His 
            500                 505                 510         


Phe Asp Ala Gly Ala Lys Phe His Val Pro Asn Val Thr Pro Tyr Ile 
        515                 520                 525             


Arg Tyr Phe Val Ser Phe Val Leu Gln Phe Gln Phe His Glu Ala Leu 
    530                 535                 540                 


Cys Lys Glu Ala Gly Tyr Glu Gly Pro Leu His Gln Cys Asp Ile Tyr 
545                 550                 555                 560 


Arg Ser Thr Lys Ala Gly Ala Lys Leu Arg Lys Val Leu Gln Ala Gly 
                565                 570                 575     


Ser Ser Arg Pro Trp Gln Glu Val Leu Lys Asp Met Val Gly Leu Asp 
            580                 585                 590         


Ala Leu Asp Ala Gln Pro Leu Leu Lys Tyr Phe Gln Pro Val Thr Gln 
        595                 600                 605             


Trp Leu Gln Glu Gln Asn Gln Gln Asn Gly Glu Val Leu Gly Trp Pro 
    610                 615                 620                 


Glu Tyr Gln Trp His Pro Pro Leu Pro Asp Asn Tyr Pro Glu Gly Ile 
625                 630                 635                 640 


Asp Leu Val Thr Asp Glu Ala Glu Ala Ser Lys Phe Val Glu Glu Tyr 
                645                 650                 655     


Asp Arg Thr Ser Gln Val Val Trp Asn Glu Tyr Ala Glu Ala Asn Trp 
            660                 665                 670         


Asn Tyr Asn Thr Asn Ile Thr Thr Glu Thr Ser Lys Ile Leu Leu Gln 
        675                 680                 685             


Lys Asn Met Gln Ile Ala Asn His Thr Leu Lys Tyr Gly Thr Gln Ala 
    690                 695                 700                 


Arg Lys Phe Asp Val Asn Gln Leu Gln Asn Thr Thr Ile Lys Arg Ile 
705                 710                 715                 720 


Ile Lys Lys Val Gln Asp Leu Glu Arg Ala Ala Leu Pro Ala Gln Glu 
                725                 730                 735     


Leu Glu Glu Tyr Asn Lys Ile Leu Leu Asp Met Glu Thr Thr Tyr Ser 
            740                 745                 750         


Val Ala Thr Val Cys His Pro Asn Gly Ser Cys Leu Gln Leu Glu Pro 
        755                 760                 765             


Asp Leu Thr Asn Val Met Ala Thr Ser Arg Lys Tyr Glu Asp Leu Leu 
    770                 775                 780                 


Trp Ala Trp Glu Gly Trp Arg Asp Lys Ala Gly Arg Ala Ile Leu Gln 
785                 790                 795                 800 


Phe Tyr Pro Lys Tyr Val Glu Leu Ile Asn Gln Ala Ala Arg Leu Asn 
                805                 810                 815     


Gly Tyr Val Asp Ala Gly Asp Ser Trp Arg Ser Met Tyr Glu Thr Pro 
            820                 825                 830         


Ser Leu Glu Gln Asp Leu Glu Arg Leu Phe Gln Glu Leu Gln Pro Leu 
        835                 840                 845             


Tyr Leu Asn Leu His Ala Tyr Val Arg Arg Ala Leu His Arg His Tyr 
    850                 855                 860                 


Gly Ala Gln His Ile Asn Leu Glu Gly Pro Ile Pro Ala His Leu Leu 
865                 870                 875                 880 


Gly Asn Met Trp Ala Gln Thr Trp Ser Asn Ile Tyr Asp Leu Val Val 
                885                 890                 895     


Pro Phe Pro Ser Ala Pro Ser Met Asp Thr Thr Glu Ala Met Leu Lys 
            900                 905                 910         


Gln Gly Trp Thr Pro Arg Arg Met Phe Lys Glu Ala Asp Asp Phe Phe 
        915                 920                 925             


Thr Ser Leu Gly Leu Leu Pro Val Pro Pro Glu Phe Trp Asn Lys Ser 
    930                 935                 940                 


Met Leu Glu Lys Pro Thr Asp Gly Arg Glu Val Val Cys His Ala Ser 
945                 950                 955                 960 


Ala Trp Asp Phe Tyr Asn Gly Lys Asp Phe Arg Ile Lys Gln Cys Thr 
                965                 970                 975     


Thr Val Asn Leu Glu Asp Leu Val Val Ala His His Glu Met Gly His 
            980                 985                 990         


Ile Gln Tyr Phe Met Gln Tyr Lys  Asp Leu Pro Val Ala  Leu Arg Glu 
        995                 1000                 1005             


Gly Ala  Asn Pro Gly Phe His  Glu Ala Ile Gly Asp  Val Leu Ala 
    1010                 1015                 1020             


Leu Ser  Val Ser Thr Pro Lys  His Leu His Ser Leu  Asn Leu Leu 
    1025                 1030                 1035             


Ser Ser  Glu Gly Gly Ser Asp  Glu His Asp Ile Asn  Phe Leu Met 
    1040                 1045                 1050             


Lys Met  Ala Leu Asp Lys Ile  Ala Phe Ile Pro Phe  Ser Tyr Leu 
    1055                 1060                 1065             


Val Asp  Gln Trp Arg Trp Arg  Val Phe Asp Gly Ser  Ile Thr Lys 
    1070                 1075                 1080             


Glu Asn  Tyr Asn Gln Glu Trp  Trp Ser Leu Arg Leu  Lys Tyr Gln 
    1085                 1090                 1095             


Gly Leu  Cys Pro Pro Val Pro  Arg Thr Gln Gly Asp  Phe Asp Pro 
    1100                 1105                 1110             


Gly Ala  Lys Phe His Ile Pro  Ser Ser Val Pro Tyr  Ile Arg Tyr 
    1115                 1120                 1125             


Phe Val  Ser Phe Ile Ile Gln  Phe Gln Phe His Glu  Ala Leu Cys 
    1130                 1135                 1140             


Gln Ala  Ala Gly His Thr Gly  Pro Leu His Lys Cys  Asp Ile Tyr 
    1145                 1150                 1155             


Gln Ser  Lys Glu Ala Gly Gln  Arg Leu Ala Thr Ala  Met Lys Leu 
    1160                 1165                 1170             


Gly Phe  Ser Arg Pro Trp Pro  Glu Ala Met Gln Leu  Ile Thr Gly 
    1175                 1180                 1185             


Gln Pro  Asn Met Ser Ala Ser  Ala Met Leu Ser Tyr  Phe Lys Pro 
    1190                 1195                 1200             


Leu Leu  Asp Trp Leu Arg Thr  Glu Asn Glu Leu His  Gly Glu Lys 
    1205                 1210                 1215             


Leu Gly  Trp Pro Gln Tyr Asn  Trp Thr Pro Asn Ser  Ala Arg Ser 
    1220                 1225                 1230             


Glu Gly  Pro Leu Pro Asp Ser  Gly Arg Val Ser Phe  Leu Gly Leu 
    1235                 1240                 1245             


Asp Leu  Asp Ala Gln Gln Ala  Arg Val Gly Gln Trp  Leu Leu Leu 
    1250                 1255                 1260             


Phe Leu  Gly Ile Ala Leu Leu  Val Ala Thr Leu Gly  Leu Ser Gln 
    1265                 1270                 1275             


Arg Leu  Phe Ser Ile Arg His  Arg Ser Leu His Arg  His Ser His 
    1280                 1285                 1290             


Gly Pro  Gln Phe Gly Ser Glu  Val Glu Leu Arg His  Ser 
    1295                 1300                 1305     


<210>  4
<211>  4969
<212>  DNA
<213>  Homo sapiens

<400>  4
agaaggggca gagccgagca ccgcgcaccg cgtcatgggg gccgcctcgg gccgccgggg       60

gccggggctg ctgctgccgc tgccgctgct gttgctgctg ccgccgcagc ccgccctggc      120

gttggacccc gggctgcagc ccggcaactt ttctgctgac gaggccgggg cgcagctctt      180

cgcgcagagc tacaactcca gcgccgaaca ggtgctgttc cagagcgtgg ccgccagctg      240

ggcgcacgac accaacatca ccgcggagaa tgcaaggcgc caggaggaag cagccctgct      300

cagccaggag tttgcggagg cctggggcca gaaggccaag gagctgtatg aaccgatctg      360

gcagaacttc acggacccgc agctgcgcag gatcatcgga gctgtgcgca ccctgggctc      420

tgccaacctg cccctggcta agcggcagca gtacaacgcc ctgctaagca acatgagcag      480

gatctactcc accgccaagg tctgcctccc caacaagact gccacctgct ggtccctgga      540

cccagatctc accaacatcc tggcttcctc gcgaagctac gccatgctcc tgtttgcctg      600

ggagggctgg cacaacgctg cgggcatccc gctgaaaccg ctgtacgagg atttcactgc      660

cctcagcaat gaagcctaca agcaggacgg cttcacagac acgggggcct actggcgctc      720

ctggtacaac tcccccacct tcgaggacga tctggaacac ctctaccaac agctagagcc      780

cctctacctg aacctccatg ccttcgtccg ccgcgcactg catcgccgat acggagacag      840

atacatcaac ctcaggggac ccatccctgc tcatctgctg ggagacatgt gggcccagag      900

ctgggaaaac atctacgaca tggtggtgcc tttcccagac aagcccaacc tcgatgtcac      960

cagtactatg ctgcagcagg gctggaacgc cacgcacatg ttccgggtgg cagaggagtt     1020

cttcacctcc ctggagctct cccccatgcc tcccgagttc tgggaagggt cgatgctgga     1080

gaagccggcc gacgggcggg aagtggtgtg ccacgcctcg gcttgggact tctacaacag     1140

gaaagacttc aggatcaagc agtgcacacg ggtcacgatg gaccagctct ccacagtgca     1200

ccatgagatg ggccatatac agtactacct gcagtacaag gatctgcccg tctccctgcg     1260

tcggggggcc aaccccggct tccatgaggc cattggggac gtgctggcgc tctcggtctc     1320

cactcctgaa catctgcaca aaatcggcct gctggaccgt gtcaccaatg acacggaaag     1380

tgacatcaat tacttgctaa aaatggcact ggaaaaaatt gccttcctgc cctttggcta     1440

cttggtggac cagtggcgct ggggggtctt tagtgggcgt accccccctt cccgctacaa     1500

cttcgactgg tggtatcttc gaaccaagta tcaggggatc tgtcctcctg ttacccgaaa     1560

cgaaacccac tttgatgctg gagctaagtt tcatgttcca aatgtgacac catacatcag     1620

gtactttgtg agttttgtcc tgcagttcca gttccatgaa gccctgtgca aggaggcagg     1680

ctatgagggc ccactgcacc agtgtgacat ctaccggtcc accaaggcag gggccaagct     1740

ccggaaggtg ctgcaggctg gctcctccag gccctggcag gaggtgctga aggacatggt     1800

cggcttagat gccctggatg cccagccgct gctcaagtac ttccagccag tcacccagtg     1860

gctgcaggag cagaaccagc agaacggcga ggtcctgggc tggcccgagt accagtggca     1920

cccgccgttg cctgacaact acccggaggg catagacctg gtgactgatg aggctgaggc     1980

cagcaagttt gtggaggaat atgaccggac atcccaggtg gtgtggaacg agtatgccga     2040

ggccaactgg aactacaaca ccaacatcac cacagagacc agcaagattc tgctgcagaa     2100

gaacatgcaa atagccaacc acaccctgaa gtacggcacc caggccagga agtttgatgt     2160

gaaccagttg cagaacacca ctatcaagcg gatcataaag aaggttcagg acctagaacg     2220

ggcagcactg cctgcccagg agctggagga gtacaacaag atcctgttgg atatggaaac     2280

cacctacagc gtggccactg tgtgccaccc gaatggcagc tgcctgcagc tcgagccaga     2340

tctgacgaat gtgatggcca cgtcccggaa atatgaagac ctgttatggg catgggaggg     2400

ctggcgagac aaggcgggga gagccatcct ccagttttac ccgaaatacg tggaactcat     2460

caaccaggct gcccggctca atggctatgt agatgcaggg gactcgtgga ggtctatgta     2520

cgagacacca tccctggagc aagacctgga gcggctcttc caggagctgc agccactcta     2580

cctcaacctg catgcctacg tgcgccgggc cctgcaccgt cactacgggg cccagcacat     2640

caacctggag gggcccattc ctgctcacct gctggggaac atgtgggcgc agacctggtc     2700

caacatctat gacttggtgg tgcccttccc ttcagccccc tcgatggaca ccacagaggc     2760

tatgctaaag cagggctgga cgcccaggag gatgtttaag gaggctgatg atttcttcac     2820

ctccctgggg ctgctgcccg tgcctcctga gttctggaac aagtcgatgc tggagaagcc     2880

aaccgacggg cgggaggtgg tctgccacgc ctcggcctgg gacttctaca acggcaagga     2940

cttccggatc aagcagtgca ccaccgtgaa cttggaggac ctggtggtgg cccaccacga     3000

aatgggccac atccagtatt tcatgcagta caaagactta cctgtggcct tgagggaggg     3060

tgccaacccc ggcttccatg aggccattgg ggacgtgcta gccctctcag tgtctacgcc     3120

caagcacctg cacagtctca acctgctgag cagtgagggt ggcagcgacg agcatgacat     3180

caactttctg atgaagatgg cccttgacaa gatcgccttt atccccttca gctacctcgt     3240

cgatcagtgg cgctggaggg tatttgatgg aagcatcacc aaggagaact ataaccagga     3300

gtggtggagc ctcaggctga agtaccaggg cctctgcccc ccagtgccca ggactcaagg     3360

tgactttgac ccaggggcca agttccacat tccttctagc gtgccttaca tcaggtactt     3420

tgtcagcttc atcatccagt tccagttcca cgaggcactg tgccaggcag ctggccacac     3480

gggccccctg cacaagtgtg acatctacca gtccaaggag gccgggcagc gcctggcgac     3540

cgccatgaag ctgggcttca gtaggccgtg gccggaagcc atgcagctga tcacgggcca     3600

gcccaacatg agcgcctcgg ccatgttgag ctacttcaag ccgctgctgg actggctccg     3660

cacggagaac gagctgcatg gggagaagct gggctggccg cagtacaact ggacgccgaa     3720

ctccgctcgc tcagaagggc ccctcccaga cagcggccgc gtcagcttcc tgggcctgga     3780

cctggatgcg cagcaggccc gcgtgggcca gtggctgctg ctcttcctgg gcatcgccct     3840

gctggtagcc accctgggcc tcagccagcg gctcttcagc atccgccacc gcagcctcca     3900

ccggcactcc cacgggcccc agttcggctc cgaggtggag ctgagacact cctgaggtga     3960

cccggctggg tcggccctgc ccaagggcct cccaccagag actgggatgg gaacactggt     4020

gggcagctga ggacacaccc cacaccccag cccaccctgc tcctcctgcc ctgtccctgt     4080

ccccctcccc tcccagtcct ccagaccacc agccgcccca gccccttctc ccagcacacg     4140

gctgcctgac actgagcccc acctctccaa gtctctctgt gaatacaatt aaaggtcctg     4200

ccctccccat ctgagtctgt gtccctcaca gggaagccag ggacagggac aggctgcttt     4260

cctgcctcct ggcagtcaag tgggtcccgt tactaggttt gttcctccat cctccttcag     4320

gagccgggga ggatccccag agctctgccc cagcacctcc tggcgctggc gcctgtcttc     4380

cctccagccc aggcagcccg ccactgtcct gccaccgcag gcagcccctg tctggcccaa     4440

gcactgaccc acgcggactc tgggaagcag acatcctggg ctgctggcct cacatttcca     4500

ctggcagtgg agcctttccc tgctccacaa atggccaggt ccccccaggg gaaggcttcc     4560

ggctgttatc ggctgcctca gggggcgagt accttggagg gcctgcttca aggagggtgc     4620

cccctggagg gcacacacca gcctagtgct taccttggct cctgcctgta ccagctccat     4680

gactctgctc gggtgaacag ccttggctct cagacagcca ttctaacact gccagtgcag     4740

aggggcctca gacgctggag tgtagcagtg gctgcacctg cacagggatt agctgccagc     4800

agccaccctg ctggcgtccc agcacacacc tcctcactcc ctgcattgga gggagtgtca     4860

ttttaaggga catttttatg acttttatgt gtatgtttat gtagaaattt ggaaaataca     4920

gaaaactgta aagaaaataa aagcccttta tatcaacgtc aagagataa                 4969


<210>  5
<211>  732
<212>  PRT
<213>  Homo sapiens

<400>  5

Met Gly Gln Gly Trp Ala Thr Ala Gly Leu Pro Ser Leu Leu Phe Leu 
1               5                   10                  15      


Leu Leu Cys Tyr Gly His Pro Leu Leu Val Pro Ser Gln Glu Ala Ser 
            20                  25                  30          


Gln Gln Val Thr Val Thr His Gly Thr Ser Ser Gln Ala Thr Thr Ser 
        35                  40                  45              


Ser Gln Thr Thr Thr His Gln Ala Thr Ala His Gln Thr Ser Ala Gln 
    50                  55                  60                  


Ser Pro Asn Leu Val Thr Asp Glu Ala Glu Ala Ser Lys Phe Val Glu 
65                  70                  75                  80  


Glu Tyr Asp Arg Thr Ser Gln Val Val Trp Asn Glu Tyr Ala Glu Ala 
                85                  90                  95      


Asn Trp Asn Tyr Asn Thr Asn Ile Thr Thr Glu Thr Ser Lys Ile Leu 
            100                 105                 110         


Leu Gln Lys Asn Met Gln Ile Ala Asn His Thr Leu Lys Tyr Gly Thr 
        115                 120                 125             


Gln Ala Arg Lys Phe Asp Val Asn Gln Leu Gln Asn Thr Thr Ile Lys 
    130                 135                 140                 


Arg Ile Ile Lys Lys Val Gln Asp Leu Glu Arg Ala Ala Leu Pro Ala 
145                 150                 155                 160 


Gln Glu Leu Glu Glu Tyr Asn Lys Ile Leu Leu Asp Met Glu Thr Thr 
                165                 170                 175     


Tyr Ser Val Ala Thr Val Cys His Pro Asn Gly Ser Cys Leu Gln Leu 
            180                 185                 190         


Glu Pro Asp Leu Thr Asn Val Met Ala Thr Ser Arg Lys Tyr Glu Asp 
        195                 200                 205             


Leu Leu Trp Ala Trp Glu Gly Trp Arg Asp Lys Ala Gly Arg Ala Ile 
    210                 215                 220                 


Leu Gln Phe Tyr Pro Lys Tyr Val Glu Leu Ile Asn Gln Ala Ala Arg 
225                 230                 235                 240 


Leu Asn Gly Tyr Val Asp Ala Gly Asp Ser Trp Arg Ser Met Tyr Glu 
                245                 250                 255     


Thr Pro Ser Leu Glu Gln Asp Leu Glu Arg Leu Phe Gln Glu Leu Gln 
            260                 265                 270         


Pro Leu Tyr Leu Asn Leu His Ala Tyr Val Arg Arg Ala Leu His Arg 
        275                 280                 285             


His Tyr Gly Ala Gln His Ile Asn Leu Glu Gly Pro Ile Pro Ala His 
    290                 295                 300                 


Leu Leu Gly Asn Met Trp Ala Gln Thr Trp Ser Asn Ile Tyr Asp Leu 
305                 310                 315                 320 


Val Val Pro Phe Pro Ser Ala Pro Ser Met Asp Thr Thr Glu Ala Met 
                325                 330                 335     


Leu Lys Gln Gly Trp Thr Pro Arg Arg Met Phe Lys Glu Ala Asp Asp 
            340                 345                 350         


Phe Phe Thr Ser Leu Gly Leu Leu Pro Val Pro Pro Glu Phe Trp Asn 
        355                 360                 365             


Lys Ser Met Leu Glu Lys Pro Thr Asp Gly Arg Glu Val Val Cys His 
    370                 375                 380                 


Ala Ser Ala Trp Asp Phe Tyr Asn Gly Lys Asp Phe Arg Ile Lys Gln 
385                 390                 395                 400 


Cys Thr Thr Val Asn Leu Glu Asp Leu Val Val Ala His His Glu Met 
                405                 410                 415     


Gly His Ile Gln Tyr Phe Met Gln Tyr Lys Asp Leu Pro Val Ala Leu 
            420                 425                 430         


Arg Glu Gly Ala Asn Pro Gly Phe His Glu Ala Ile Gly Asp Val Leu 
        435                 440                 445             


Ala Leu Ser Val Ser Thr Pro Lys His Leu His Ser Leu Asn Leu Leu 
    450                 455                 460                 


Ser Ser Glu Gly Gly Ser Asp Glu His Asp Ile Asn Phe Leu Met Lys 
465                 470                 475                 480 


Met Ala Leu Asp Lys Ile Ala Phe Ile Pro Phe Ser Tyr Leu Val Asp 
                485                 490                 495     


Gln Trp Arg Trp Arg Val Phe Asp Gly Ser Ile Thr Lys Glu Asn Tyr 
            500                 505                 510         


Asn Gln Glu Trp Trp Ser Leu Arg Leu Lys Tyr Gln Gly Leu Cys Pro 
        515                 520                 525             


Pro Val Pro Arg Thr Gln Gly Asp Phe Asp Pro Gly Ala Lys Phe His 
    530                 535                 540                 


Ile Pro Ser Ser Val Pro Tyr Ile Arg Tyr Phe Val Ser Phe Ile Ile 
545                 550                 555                 560 


Gln Phe Gln Phe His Glu Ala Leu Cys Gln Ala Ala Gly His Thr Gly 
                565                 570                 575     


Pro Leu His Lys Cys Asp Ile Tyr Gln Ser Lys Glu Ala Gly Gln Arg 
            580                 585                 590         


Leu Ala Thr Ala Met Lys Leu Gly Phe Ser Arg Pro Trp Pro Glu Ala 
        595                 600                 605             


Met Gln Leu Ile Thr Gly Gln Pro Asn Met Ser Ala Ser Ala Met Leu 
    610                 615                 620                 


Ser Tyr Phe Lys Pro Leu Leu Asp Trp Leu Arg Thr Glu Asn Glu Leu 
625                 630                 635                 640 


His Gly Glu Lys Leu Gly Trp Pro Gln Tyr Asn Trp Thr Pro Asn Ser 
                645                 650                 655     


Ala Arg Ser Glu Gly Pro Leu Pro Asp Ser Gly Arg Val Ser Phe Leu 
            660                 665                 670         


Gly Leu Asp Leu Asp Ala Gln Gln Ala Arg Val Gly Gln Trp Leu Leu 
        675                 680                 685             


Leu Phe Leu Gly Ile Ala Leu Leu Val Ala Thr Leu Gly Leu Ser Gln 
    690                 695                 700                 


Arg Leu Phe Ser Ile Arg His Arg Ser Leu His Arg His Ser His Gly 
705                 710                 715                 720 


Pro Gln Phe Gly Ser Glu Val Glu Leu Arg His Ser 
                725                 730         


<210>  6
<211>  3264
<212>  DNA
<213>  Homo sapiens

<400>  6
gctcttattg gccaggggac ggtagctgca ggactctgct ctcctgcggc catgggccag       60

ggttgggcta ctgcaggact tcccagcctc ctcttcctgc tgctctgcta cgggcaccct      120

ctgctggtcc ccagccagga ggcatcccaa caggtgacag tcacccatgg gacaagcagc      180

caggcaacaa ccagcagcca gacaaccacc caccaggcga cggcccacca gacatcagcc      240

cagagcccaa acctggtgac tgatgaggct gaggccagca agtttgtgga ggaatatgac      300

cggacatccc aggtggtgtg gaacgagtat gccgaggcca actggaacta caacaccaac      360

atcaccacag agaccagcaa gattctgctg cagaagaaca tgcaaatagc caaccacacc      420

ctgaagtacg gcacccaggc caggaagttt gatgtgaacc agttgcagaa caccactatc      480

aagcggatca taaagaaggt tcaggaccta gaacgggcag cactgcctgc ccaggagctg      540

gaggagtaca acaagatcct gttggatatg gaaaccacct acagcgtggc cactgtgtgc      600

cacccgaatg gcagctgcct gcagctcgag ccagatctga cgaatgtgat ggccacgtcc      660

cggaaatatg aagacctgtt atgggcatgg gagggctggc gagacaaggc ggggagagcc      720

atcctccagt tttacccgaa atacgtggaa ctcatcaacc aggctgcccg gctcaatggc      780

tatgtagatg caggggactc gtggaggtct atgtacgaga caccatccct ggagcaagac      840

ctggagcggc tcttccagga gctgcagcca ctctacctca acctgcatgc ctacgtgcgc      900

cgggccctgc accgtcacta cggggcccag cacatcaacc tggaggggcc cattcctgct      960

cacctgctgg ggaacatgtg ggcgcagacc tggtccaaca tctatgactt ggtggtgccc     1020

ttcccttcag ccccctcgat ggacaccaca gaggctatgc taaagcaggg ctggacgccc     1080

aggaggatgt ttaaggaggc tgatgatttc ttcacctccc tggggctgct gcccgtgcct     1140

cctgagttct ggaacaagtc gatgctggag aagccaaccg acgggcggga ggtggtctgc     1200

cacgcctcgg cctgggactt ctacaacggc aaggacttcc ggatcaagca gtgcaccacc     1260

gtgaacttgg aggacctggt ggtggcccac cacgaaatgg gccacatcca gtatttcatg     1320

cagtacaaag acttacctgt ggccttgagg gagggtgcca accccggctt ccatgaggcc     1380

attggggacg tgctagccct ctcagtgtct acgcccaagc acctgcacag tctcaacctg     1440

ctgagcagtg agggtggcag cgacgagcat gacatcaact ttctgatgaa gatggccctt     1500

gacaagatcg cctttatccc cttcagctac ctcgtcgatc agtggcgctg gagggtattt     1560

gatggaagca tcaccaagga gaactataac caggagtggt ggagcctcag gctgaagtac     1620

cagggcctct gccccccagt gcccaggact caaggtgact ttgacccagg ggccaagttc     1680

cacattcctt ctagcgtgcc ttacatcagg tactttgtca gcttcatcat ccagttccag     1740

ttccacgagg cactgtgcca ggcagctggc cacacgggcc ccctgcacaa gtgtgacatc     1800

taccagtcca aggaggccgg gcagcgcctg gcgaccgcca tgaagctggg cttcagtagg     1860

ccgtggccgg aagccatgca gctgatcacg ggccagccca acatgagcgc ctcggccatg     1920

ttgagctact tcaagccgct gctggactgg ctccgcacgg agaacgagct gcatggggag     1980

aagctgggct ggccgcagta caactggacg ccgaactccg ctcgctcaga agggcccctc     2040

ccagacagcg gccgcgtcag cttcctgggc ctggacctgg atgcgcagca ggcccgcgtg     2100

ggccagtggc tgctgctctt cctgggcatc gccctgctgg tagccaccct gggcctcagc     2160

cagcggctct tcagcatccg ccaccgcagc ctccaccggc actcccacgg gccccagttc     2220

ggctccgagg tggagctgag acactcctga ggtgacccgg ctgggtcggc cctgcccaag     2280

ggcctcccac cagagactgg gatgggaaca ctggtgggca gctgaggaca caccccacac     2340

cccagcccac cctgctcctc ctgccctgtc cctgtccccc tcccctccca gtcctccaga     2400

ccaccagccg ccccagcccc ttctcccagc acacggctgc ctgacactga gccccacctc     2460

tccaagtctc tctgtgaata caattaaagg tcctgccctc cccatctgag tctgtgtccc     2520

tcacagggaa gccagggaca gggacaggct gctttcctgc ctcctggcag tcaagtgggt     2580

cccgttacta ggtttgttcc tccatcctcc ttcaggagcc ggggaggatc cccagagctc     2640

tgccccagca cctcctggcg ctggcgcctg tcttccctcc agcccaggca gcccgccact     2700

gtcctgccac cgcaggcagc ccctgtctgg cccaagcact gacccacgcg gactctggga     2760

agcagacatc ctgggctgct ggcctcacat ttccactggc agtggagcct ttccctgctc     2820

cacaaatggc caggtccccc caggggaagg cttccggctg ttatcggctg cctcaggggg     2880

cgagtacctt ggagggcctg cttcaaggag ggtgccccct ggagggcaca caccagccta     2940

gtgcttacct tggctcctgc ctgtaccagc tccatgactc tgctcgggtg aacagccttg     3000

gctctcagac agccattcta acactgccag tgcagagggg cctcagacgc tggagtgtag     3060

cagtggctgc acctgcacag ggattagctg ccagcagcca ccctgctggc gtcccagcac     3120

acacctcctc actccctgca ttggagggag tgtcatttta agggacattt ttatgacttt     3180

tatgtgtatg tttatgtaga aatttggaaa atacagaaaa ctgtaaagaa aataaaagcc     3240

ctttatatca acgtcaagag ataa                                            3264


<210>  7
<211>  691
<212>  PRT
<213>  Homo sapiens

<400>  7

Met Gly Gln Gly Trp Ala Thr Ala Gly Leu Pro Ser Leu Leu Phe Leu 
1               5                   10                  15      


Leu Leu Cys Tyr Gly His Pro Leu Leu Val Pro Ser Gln Glu Ala Ser 
            20                  25                  30          


Gln Gln Val Thr Val Thr His Gly Thr Ser Ser Gln Ala Thr Thr Ser 
        35                  40                  45              


Ser Gln Thr Thr Thr His Gln Ala Thr Ala His Gln Thr Ser Ala Gln 
    50                  55                  60                  


Ser Pro Asn Leu Val Thr Asp Glu Ala Glu Ala Ser Lys Phe Val Glu 
65                  70                  75                  80  


Glu Tyr Asp Arg Thr Ser Gln Val Val Trp Asn Glu Tyr Ala Glu Ala 
                85                  90                  95      


Asn Trp Asn Tyr Asn Thr Asn Ile Thr Thr Glu Thr Ser Lys Ile Leu 
            100                 105                 110         


Leu Gln Lys Asn Met Gln Ile Ala Asn His Thr Leu Lys Tyr Gly Thr 
        115                 120                 125             


Gln Ala Arg Lys Phe Asp Val Asn Gln Leu Gln Asn Thr Thr Ile Lys 
    130                 135                 140                 


Arg Ile Ile Lys Lys Val Gln Asp Leu Glu Arg Ala Ala Leu Pro Ala 
145                 150                 155                 160 


Gln Glu Leu Glu Glu Tyr Asn Lys Ile Leu Leu Asp Met Glu Thr Thr 
                165                 170                 175     


Tyr Ser Val Ala Thr Val Cys His Pro Asn Gly Ser Cys Leu Gln Leu 
            180                 185                 190         


Glu Pro Asp Leu Thr Asn Val Met Ala Thr Ser Arg Lys Tyr Glu Asp 
        195                 200                 205             


Leu Leu Trp Ala Trp Glu Gly Trp Arg Asp Lys Ala Gly Arg Ala Ile 
    210                 215                 220                 


Leu Gln Phe Tyr Pro Lys Tyr Val Glu Leu Ile Asn Gln Ala Ala Arg 
225                 230                 235                 240 


Leu Asn Gly Tyr Val Asp Ala Gly Asp Ser Trp Arg Ser Met Tyr Glu 
                245                 250                 255     


Thr Pro Ser Leu Glu Gln Asp Leu Glu Arg Leu Phe Gln Glu Leu Gln 
            260                 265                 270         


Pro Leu Tyr Leu Asn Leu His Ala Tyr Val Arg Arg Ala Leu His Arg 
        275                 280                 285             


His Tyr Gly Ala Gln His Ile Asn Leu Glu Gly Pro Ile Pro Ala His 
    290                 295                 300                 


Leu Leu Gly Asn Met Trp Ala Gln Thr Trp Ser Asn Ile Tyr Asp Leu 
305                 310                 315                 320 


Val Val Pro Phe Pro Ser Ala Pro Ser Met Asp Thr Thr Glu Ala Met 
                325                 330                 335     


Leu Lys Gln Gly Trp Thr Pro Arg Arg Met Phe Lys Glu Ala Asp Asp 
            340                 345                 350         


Phe Phe Thr Ser Leu Gly Leu Leu Pro Val Pro Pro Glu Phe Trp Asn 
        355                 360                 365             


Lys Ser Met Leu Glu Lys Pro Thr Asp Gly Arg Glu Val Val Cys His 
    370                 375                 380                 


Ala Ser Ala Trp Asp Phe Tyr Asn Gly Lys Asp Phe Arg Ile Lys Gln 
385                 390                 395                 400 


Cys Thr Thr Val Asn Leu Glu Asp Leu Val Val Ala His His Glu Met 
                405                 410                 415     


Gly His Ile Gln Tyr Phe Met Gln Tyr Lys Asp Leu Pro Val Ala Leu 
            420                 425                 430         


Arg Glu Gly Ala Asn Pro Gly Phe His Glu Ala Ile Gly Asp Val Leu 
        435                 440                 445             


Ala Leu Ser Val Ser Thr Pro Lys His Leu His Ser Leu Asn Leu Leu 
    450                 455                 460                 


Ser Ser Glu Gly Gly Ser Asp Glu His Asp Ile Asn Phe Leu Met Lys 
465                 470                 475                 480 


Met Ala Leu Asp Lys Ile Ala Phe Ile Pro Phe Ser Tyr Leu Val Asp 
                485                 490                 495     


Gln Trp Arg Trp Arg Val Phe Asp Gly Ser Ile Thr Lys Glu Asn Tyr 
            500                 505                 510         


Asn Gln Glu Trp Trp Ser Leu Arg Leu Lys Tyr Gln Gly Leu Cys Pro 
        515                 520                 525             


Pro Val Pro Arg Thr Gln Gly Asp Phe Asp Pro Gly Ala Lys Phe His 
    530                 535                 540                 


Ile Pro Ser Ser Val Pro Tyr Ile Arg Thr Ala Met Lys Leu Gly Phe 
545                 550                 555                 560 


Ser Arg Pro Trp Pro Glu Ala Met Gln Leu Ile Thr Gly Gln Pro Asn 
                565                 570                 575     


Met Ser Ala Ser Ala Met Leu Ser Tyr Phe Lys Pro Leu Leu Asp Trp 
            580                 585                 590         


Leu Arg Thr Glu Asn Glu Leu His Gly Glu Lys Leu Gly Trp Pro Gln 
        595                 600                 605             


Tyr Asn Trp Thr Pro Asn Ser Ala Arg Ser Glu Gly Pro Leu Pro Asp 
    610                 615                 620                 


Ser Gly Arg Val Ser Phe Leu Gly Leu Asp Leu Asp Ala Gln Gln Ala 
625                 630                 635                 640 


Arg Val Gly Gln Trp Leu Leu Leu Phe Leu Gly Ile Ala Leu Leu Val 
                645                 650                 655     


Ala Thr Leu Gly Leu Ser Gln Arg Leu Phe Ser Ile Arg His Arg Ser 
            660                 665                 670         


Leu His Arg His Ser His Gly Pro Gln Phe Gly Ser Glu Val Glu Leu 
        675                 680                 685             


Arg His Ser 
    690     


<210>  8
<211>  3141
<212>  DNA
<213>  Homo sapiens

<400>  8
gctcttattg gccaggggac ggtagctgca ggactctgct ctcctgcggc catgggccag       60

ggttgggcta ctgcaggact tcccagcctc ctcttcctgc tgctctgcta cgggcaccct      120

ctgctggtcc ccagccagga ggcatcccaa caggtgacag tcacccatgg gacaagcagc      180

caggcaacaa ccagcagcca gacaaccacc caccaggcga cggcccacca gacatcagcc      240

cagagcccaa acctggtgac tgatgaggct gaggccagca agtttgtgga ggaatatgac      300

cggacatccc aggtggtgtg gaacgagtat gccgaggcca actggaacta caacaccaac      360

atcaccacag agaccagcaa gattctgctg cagaagaaca tgcaaatagc caaccacacc      420

ctgaagtacg gcacccaggc caggaagttt gatgtgaacc agttgcagaa caccactatc      480

aagcggatca taaagaaggt tcaggaccta gaacgggcag cactgcctgc ccaggagctg      540

gaggagtaca acaagatcct gttggatatg gaaaccacct acagcgtggc cactgtgtgc      600

cacccgaatg gcagctgcct gcagctcgag ccagatctga cgaatgtgat ggccacgtcc      660

cggaaatatg aagacctgtt atgggcatgg gagggctggc gagacaaggc ggggagagcc      720

atcctccagt tttacccgaa atacgtggaa ctcatcaacc aggctgcccg gctcaatggc      780

tatgtagatg caggggactc gtggaggtct atgtacgaga caccatccct ggagcaagac      840

ctggagcggc tcttccagga gctgcagcca ctctacctca acctgcatgc ctacgtgcgc      900

cgggccctgc accgtcacta cggggcccag cacatcaacc tggaggggcc cattcctgct      960

cacctgctgg ggaacatgtg ggcgcagacc tggtccaaca tctatgactt ggtggtgccc     1020

ttcccttcag ccccctcgat ggacaccaca gaggctatgc taaagcaggg ctggacgccc     1080

aggaggatgt ttaaggaggc tgatgatttc ttcacctccc tggggctgct gcccgtgcct     1140

cctgagttct ggaacaagtc gatgctggag aagccaaccg acgggcggga ggtggtctgc     1200

cacgcctcgg cctgggactt ctacaacggc aaggacttcc ggatcaagca gtgcaccacc     1260

gtgaacttgg aggacctggt ggtggcccac cacgaaatgg gccacatcca gtatttcatg     1320

cagtacaaag acttacctgt ggccttgagg gagggtgcca accccggctt ccatgaggcc     1380

attggggacg tgctagccct ctcagtgtct acgcccaagc acctgcacag tctcaacctg     1440

ctgagcagtg agggtggcag cgacgagcat gacatcaact ttctgatgaa gatggccctt     1500

gacaagatcg cctttatccc cttcagctac ctcgtcgatc agtggcgctg gagggtattt     1560

gatggaagca tcaccaagga gaactataac caggagtggt ggagcctcag gctgaagtac     1620

cagggcctct gccccccagt gcccaggact caaggtgact ttgacccagg ggccaagttc     1680

cacattcctt ctagcgtgcc ttacatcagg accgccatga agctgggctt cagtaggccg     1740

tggccggaag ccatgcagct gatcacgggc cagcccaaca tgagcgcctc ggccatgttg     1800

agctacttca agccgctgct ggactggctc cgcacggaga acgagctgca tggggagaag     1860

ctgggctggc cgcagtacaa ctggacgccg aactccgctc gctcagaagg gcccctccca     1920

gacagcggcc gcgtcagctt cctgggcctg gacctggatg cgcagcaggc ccgcgtgggc     1980

cagtggctgc tgctcttcct gggcatcgcc ctgctggtag ccaccctggg cctcagccag     2040

cggctcttca gcatccgcca ccgcagcctc caccggcact cccacgggcc ccagttcggc     2100

tccgaggtgg agctgagaca ctcctgaggt gacccggctg ggtcggccct gcccaagggc     2160

ctcccaccag agactgggat gggaacactg gtgggcagct gaggacacac cccacacccc     2220

agcccaccct gctcctcctg ccctgtccct gtccccctcc cctcccagtc ctccagacca     2280

ccagccgccc cagccccttc tcccagcaca cggctgcctg acactgagcc ccacctctcc     2340

aagtctctct gtgaatacaa ttaaaggtcc tgccctcccc atctgagtct gtgtccctca     2400

cagggaagcc agggacaggg acaggctgct ttcctgcctc ctggcagtca agtgggtccc     2460

gttactaggt ttgttcctcc atcctccttc aggagccggg gaggatcccc agagctctgc     2520

cccagcacct cctggcgctg gcgcctgtct tccctccagc ccaggcagcc cgccactgtc     2580

ctgccaccgc aggcagcccc tgtctggccc aagcactgac ccacgcggac tctgggaagc     2640

agacatcctg ggctgctggc ctcacatttc cactggcagt ggagcctttc cctgctccac     2700

aaatggccag gtccccccag gggaaggctt ccggctgtta tcggctgcct cagggggcga     2760

gtaccttgga gggcctgctt caaggagggt gccccctgga gggcacacac cagcctagtg     2820

cttaccttgg ctcctgcctg taccagctcc atgactctgc tcgggtgaac agccttggct     2880

ctcagacagc cattctaaca ctgccagtgc agaggggcct cagacgctgg agtgtagcag     2940

tggctgcacc tgcacaggga ttagctgcca gcagccaccc tgctggcgtc ccagcacaca     3000

cctcctcact ccctgcattg gagggagtgt cattttaagg gacattttta tgacttttat     3060

gtgtatgttt atgtagaaat ttggaaaata cagaaaactg taaagaaaat aaaagccctt     3120

tatatcaacg tcaagagata a                                               3141


