﻿               SEQUENCE LISTING

<110> Consejo Superior de Investigaciones Científicas
      CIBER Enfermedades Respiratorias

<120> ENZIBIÓTICOS BACTERICIDAS MEJORADOS FRENTE A NEUMOCOCO Y OTRAS BACTERIAS 

<130> 2013-0312

<150>  P201330777
<151>  2013-05-28

<160> 26

<170> BiSSAP 1.2

<210> 1
<211> 342
<212> PRT
<213> Cp-7 

<220> 
<223> Native Sequence

<400> 1
Met Val Lys Lys Asn Asp Leu Phe Val Asp Val Ala Ser His Gln Gly 
1               5                   10                  15      
Tyr Asp Ile Ser Gly Ile Leu Glu Glu Ala Gly Thr Thr Asn Thr Ile 
            20                  25                  30          
Ile Lys Val Ser Glu Ser Thr Ser Tyr Leu Asn Pro Cys Leu Ser Ala 
        35                  40                  45              
Gln Val Ser Gln Ser Asn Pro Ile Gly Phe Tyr His Phe Ala Trp Phe 
    50                  55                  60                  
Gly Gly Asn Glu Glu Glu Ala Glu Ala Glu Ala Arg Tyr Phe Leu Asp 
65                  70                  75                  80  
Asn Val Pro Thr Gln Val Lys Tyr Leu Val Leu Asp Tyr Glu Asp His 
                85                  90                  95      
Ala Ser Ala Ser Val Gln Arg Asn Thr Thr Ala Cys Leu Arg Phe Met 
            100                 105                 110         
Gln Ile Ile Ala Glu Ala Gly Tyr Thr Pro Ile Tyr Tyr Ser Tyr Lys 
        115                 120                 125             
Pro Phe Thr Leu Asp Asn Val Asp Tyr Gln Gln Ile Leu Ala Gln Phe 
    130                 135                 140                 
Pro Asn Ser Leu Trp Ile Ala Gly Tyr Gly Leu Asn Asp Gly Thr Ala 
145                 150                 155                 160 
Asn Phe Glu Tyr Phe Pro Ser Met Asp Gly Ile Arg Trp Trp Gln Tyr 
                165                 170                 175     
Ser Ser Asn Pro Phe Asp Lys Asn Ile Val Leu Leu Asp Asp Glu Lys 
            180                 185                 190         
Glu Asp Asn Ile Asn Asn Glu Asn Thr Leu Lys Ser Leu Thr Thr Val 
        195                 200                 205             
Ala Asn Glu Val Ile Gln Gly Leu Trp Gly Asn Gly Gln Glu Arg Tyr 
    210                 215                 220                 
Asp Ser Leu Ala Asn Ala Gly Tyr Asp Pro Gln Ala Val Gln Asp Lys 
225                 230                 235                 240 
Val Asn Glu Ile Leu Asn Ala Arg Glu Ile Ala Asp Leu Thr Thr Val 
                245                 250                 255     
Ala Asn Glu Val Ile Gln Gly Leu Trp Gly Asn Gly Gln Glu Arg Tyr 
            260                 265                 270         
Asp Ser Leu Ala Asn Ala Gly Tyr Asp Pro Gln Ala Val Gln Asp Lys 
        275                 280                 285             
Val Asn Glu Ile Leu Asn Ala Arg Glu Ile Ala Asp Leu Thr Thr Val 
    290                 295                 300                 
Ala Asn Glu Val Ile Gln Gly Leu Trp Gly Asn Gly Gln Glu Arg Tyr 
305                 310                 315                 320 
Asp Ser Leu Ala Asn Ala Gly Tyr Asp Pro Gln Ala Val Gln Asp Lys 
                325                 330                 335     
Val Asn Glu Leu Leu Ser 
            340         

<210> 2
<211> 1029
<212> DNA
<213> Cp-7

<220> 
<221> source
<222> 1..1029
<223> /mol_type="unassigned DNA"
      /organism="Cp-7"

<400> 2
atggttaaga aaaatgattt atttgtagac gttgcaagcc atcaaggcta cgacatttca      60

ggaattttag aagaagcagg gacaacaaac acaattatta aagtgtcaga aagtacaagc     120

tatttaaacc cttgcttgtc tgctcaagtg agccagtcaa atcctatcgg gttttatcat     180

tttgcttggt ttggtggaaa tgaagaagaa gcagaagcag aagcacgcta tttccttgat     240

aacgtgccta cacaagttaa ataccttgta ctagattatg aagaccatgc aagcgcaagc     300

gtacaaagaa acactaccgc gtgcttacgc tttatgcaaa ttatcgcaga agctggatat     360

acacctattt attatagtta caaaccgttt acgcttgata atgtggacta tcagcagatt     420

ttagcacagt tccctaattc tctatggatt gcaggctatg gcttaaatga tggtacagct     480

aactttgaat actttccaag catggacggt atcagatggt ggcaatattc tagtaacccg     540

tttgacaaga atattgtact gttagatgat gagaaagaag ataatataaa caatgaaaac     600

actctaaaaa gccttaccac agtagccaac gaggtcattc agggactttg gggcaacggt     660

caagaacgtt atgacagttt agcgaatgca gggtatgacc cccaagcggt tcaagacaaa     720

gtgaatgaaa tcttaaacgc tagagaaatt gcagacctta ccacagtagc caacgaggtc     780

attcagggac tttggggcaa cggtcaagaa cgttatgaca gtttagcgaa tgcagggtat     840

gacccccaag cggttcaaga caaagtgaat gaaatcttaa acgctagaga aattgcagac     900

cttaccacag tagccaacga ggtcattcag ggactttggg gcaacggtca agaacgttat     960

gacagtttag cgaatgcagg gtatgacccc caagcggttc aagacaaagt gaatgaatta    1020

ctttcataa                                                            1029


<210> 3
<211> 188
<212> PRT
<213> Cp-7

<220> 
<223> N-terminal domain Cpl-7

<400> 3
Met Val Lys Lys Asn Asp Leu Phe Val Asp Val Ala Ser His Gln Gly 
1               5                   10                  15      
Tyr Asp Ile Ser Gly Ile Leu Glu Glu Ala Gly Thr Thr Asn Thr Ile 
            20                  25                  30          
Ile Lys Val Ser Glu Ser Thr Ser Tyr Leu Asn Pro Cys Leu Ser Ala 
        35                  40                  45              
Gln Val Ser Gln Ser Asn Pro Ile Gly Phe Tyr His Phe Ala Trp Phe 
    50                  55                  60                  
Gly Gly Asn Glu Glu Glu Ala Glu Ala Glu Ala Arg Tyr Phe Leu Asp 
65                  70                  75                  80  
Asn Val Pro Thr Gln Val Lys Tyr Leu Val Leu Asp Tyr Glu Asp His 
                85                  90                  95      
Ala Ser Ala Ser Val Gln Arg Asn Thr Thr Ala Cys Leu Arg Phe Met 
            100                 105                 110         
Gln Ile Ile Ala Glu Ala Gly Tyr Thr Pro Ile Tyr Tyr Ser Tyr Lys 
        115                 120                 125             
Pro Phe Thr Leu Asp Asn Val Asp Tyr Gln Gln Ile Leu Ala Gln Phe 
    130                 135                 140                 
Pro Asn Ser Leu Trp Ile Ala Gly Tyr Gly Leu Asn Asp Gly Thr Ala 
145                 150                 155                 160 
Asn Phe Glu Tyr Phe Pro Ser Met Asp Gly Ile Arg Trp Trp Gln Tyr 
                165                 170                 175     
Ser Ser Asn Pro Phe Asp Lys Asn Ile Val Leu Leu 
            180                 185             

<210> 4
<211> 564
<212> DNA
<213> Cp-7

<220> 
<221> source
<222> 1..564
<223> /mol_type="unassigned DNA"
      /note="N-terminal domain Cpl-7"
      /organism="Cp-7"

<400> 4
atggttaaga aaaatgattt atttgtagac gttgcaagcc atcaaggcta cgacatttca      60

ggaattttag aagaagcagg gacaacaaac acaattatta aagtgtcaga aagtacaagc     120

tatttaaacc cttgcttgtc tgctcaagtg agccagtcaa atcctatcgg gttttatcat     180

tttgcttggt ttggtggaaa tgaagaagaa gcagaagcag aagcacgcta tttccttgat     240

aacgtgccta cacaagttaa ataccttgta ctagattatg aagaccatgc aagcgcaagc     300

gtacaaagaa acactaccgc gtgcttacgc tttatgcaaa ttatcgcaga agctggatat     360

acacctattt attatagtta caaaccgttt acgcttgata atgtggacta tcagcagatt     420

ttagcacagt tccctaattc tctatggatt gcaggctatg gcttaaatga tggtacagct     480

aactttgaat actttccaag catggacggt atcagatggt ggcaatattc tagtaacccg     540

tttgacaaga atattgtact gtta                                            564


<210> 5
<211> 16
<212> PRT
<213> Cp-7

<220> 
<223> Linker Cpl-7

<400> 5
Asp Asp Glu Lys Glu Asp Asn Ile Asn Asn Glu Asn Thr Leu Lys Ser 
1               5                   10                  15      



<210> 6
<211> 45
<212> DNA
<213> Cp-7

<220> 
<221> source
<222> 1..45
<223> /mol_type="unassigned DNA"
      /note="Linker Cpl-7"
      /organism="Cp-7"

<400> 6
gatgatgaga aagaagataa tataaacaat gaaaacactc taaaa                     45


<210> 7
<211> 138
<212> PRT
<213> Cp-7

<220> 
<223> C-Terminal domain

<400> 7
Leu Thr Thr Val Ala Asn Glu Val Ile Gln Gly Leu Trp Gly Asn Gly 
1               5                   10                  15      
Gln Glu Arg Tyr Asp Ser Leu Ala Asn Ala Gly Tyr Asp Pro Gln Ala 
            20                  25                  30          
Val Gln Asp Lys Val Asn Glu Ile Leu Asn Ala Arg Glu Ile Ala Asp 
        35                  40                  45              
Leu Thr Thr Val Ala Asn Glu Val Ile Gln Gly Leu Trp Gly Asn Gly 
    50                  55                  60                  
Gln Glu Arg Tyr Asp Ser Leu Ala Asn Ala Gly Tyr Asp Pro Gln Ala 
65                  70                  75                  80  
Val Gln Asp Lys Val Asn Glu Ile Leu Asn Ala Arg Glu Ile Ala Asp 
                85                  90                  95      
Leu Thr Thr Val Ala Asn Glu Val Ile Gln Gly Leu Trp Gly Asn Gly 
            100                 105                 110         
Gln Glu Arg Tyr Asp Ser Leu Ala Asn Ala Gly Tyr Asp Pro Gln Ala 
        115                 120                 125             
Val Gln Asp Lys Val Asn Glu Leu Leu Ser 
    130                 135             

<210> 8
<211> 420
<212> DNA
<213> Cp-7

<220> 
<221> source
<222> 1..420
<223> /mol_type="unassigned DNA"
      /note="C-terminal domain Cpl-7"
      /organism="Cp-7"

<400> 8
agccttacca cagtagccaa cgaggtcatt cagggacttt ggggcaacgg tcaagaacgt      60

tatgacagtt tagcgaatgc agggtatgac ccccaagcgg ttcaagacaa agtgaatgaa     120

atcttaaacg ctagagaaat tgcagacctt accacagtag ccaacgaggt cattcaggga     180

ctttggggca acggtcaaga acgttatgac agtttagcga atgcagggta tgacccccaa     240

gcggttcaag acaaagtgaa tgaaatctta aacgctagag aaattgcaga ccttaccaca     300

gtagccaacg aggtcattca gggactttgg ggcaacggtc aagaacgtta tgacagttta     360

gcgaatgcag ggtatgaccc ccaagcggtt caagacaaag tgaatgaatt actttcataa     420


<210> 9
<211> 188
<212> PRT
<213> Cp-7

<220> 
<223> N-terminal domain Mutant 7N

<400> 9
Met Val Lys Lys Asn Asp Leu Phe Val Asp Val Ala Ser His Gln Gly 
1               5                   10                  15      
Tyr Asp Ile Ser Gly Ile Leu Glu Gln Ala Gly Thr Thr Asn Thr Ile 
            20                  25                  30          
Ile Lys Val Ser Glu Ser Thr Ser Tyr Leu Asn Pro Cys Leu Ser Ala 
        35                  40                  45              
Gln Val Ser Gln Ser Asn Pro Ile Gly Phe Tyr His Phe Ala Trp Phe 
    50                  55                  60                  
Gly Gly Asn Gln Ala Glu Ala Glu Ala Glu Ala Arg Tyr Phe Leu Asp 
65                  70                  75                  80  
Asn Val Pro Thr Gln Val Lys Tyr Leu Val Leu Asp Tyr Glu Asp His 
                85                  90                  95      
Ala Ser Ala Ser Val Gln Arg Asn Thr Thr Ala Cys Leu Arg Phe Met 
            100                 105                 110         
Gln Ile Ile Ala Glu Ala Gly Tyr Thr Pro Ile Tyr Tyr Ser Tyr Lys 
        115                 120                 125             
Pro Phe Thr Leu Asp Asn Val Asp Tyr Gln Gln Ile Leu Ala Gln Phe 
    130                 135                 140                 
Pro Asn Ser Leu Trp Ile Ala Gly Tyr Gly Leu Asn Asp Gly Thr Ala 
145                 150                 155                 160 
Asn Phe Glu Tyr Phe Pro Ser Met Asp Gly Ile Arg Trp Trp Gln Tyr 
                165                 170                 175     
Ser Ser Asn Pro Phe Asp Lys Asn Ile Val Leu Leu 
            180                 185             

<210> 10
<211> 564
<212> DNA
<213> Cp-7

<220> 
<221> source
<222> 1..564
<223> /mol_type="unassigned DNA"
      /note="N-terminal domain Mutant Cpl-7N"
      /organism="Cp-7"

<400> 10
atggttaaaa agaacgacct gttcgttgac gttgcgtctc accagggtta cgacatctct      60

ggtatcctgg aacaggcggg taccaccaac accatcatca aagtttctga atctaccagc     120

tacctgaacc cgtgcctgtc tgcgcaggtt tctcagtcta acccgatcgg tttctaccac     180

ttcgcgtggt tcggtggtaa ccaggcggaa gcggaagcgg aagcgcgtta cttcctggac     240

aacgttccga cccaggttaa atacctggtt ctggactacg aagaccacgc gtctgcgtct     300

gttcagcgta acaccaccgc gtgcctgcgt ttcatgcaga tcatcgcgga agcgggttac     360

accccgatct actactctta caaaccgttc accctggaca acgttgacta ccagcagatc     420

ctggcgcagt tcccgaactc tctgtggatc gcgggttacg gtctgaacga cggtaccgcg     480

aacttcgaat acttcccgtc tatggacggt atccgttggt ggcagtactc ttctaacccg     540

ttcgacaaaa acatcgttct gctg                                            564


<210> 11
<211> 138
<212> PRT
<213> Cp-7

<220> 
<223> C-terminal domain Mutant Cpl-7S

<400> 11
Leu Thr Thr Val Ala Asn Glu Val Ile Gln Gly Lys Trp Gly Asn Gly 
1               5                   10                  15      
Gln Glu Arg Tyr Lys Ser Leu Ala Asn Arg Gly Tyr Asn Pro Gln Ala 
            20                  25                  30          
Val Gln Asn Lys Val Asn Glu Ile Leu Asn Ala Arg Glu Ile Ala Asp 
        35                  40                  45              
Leu Thr Thr Val Ala Asn Glu Val Ile Gln Gly Lys Trp Gly Asn Gly 
    50                  55                  60                  
Gln Glu Arg Tyr Lys Ser Leu Ala Asn Arg Gly Tyr Asn Pro Gln Ala 
65                  70                  75                  80  
Val Gln Asn Lys Val Asn Glu Ile Leu Asn Ala Arg Glu Ile Ala Asp 
                85                  90                  95      
Leu Thr Thr Val Ala Asn Glu Val Ile Gln Gly Lys Trp Gly Asn Gly 
            100                 105                 110         
Gln Glu Arg Tyr Lys Ser Leu Ala Asn Arg Gly Tyr Asn Pro Gln Ala 
        115                 120                 125             
Val Gln Asn Lys Val Asn Glu Leu Leu Ser 
    130                 135             

<210> 12
<211> 415
<212> DNA
<213> Cp-7

<220> 
<221> source
<222> 1..415
<223> /mol_type="unassigned DNA"
      /note="C-terminal domain Mutant 7N"
      /organism="Cp-7"

<400> 12
gacgaccgtt gcgaatgaag ttatccaagg taaatggggt aatggccagg agcgctacaa      60

atctctggcc aaccgtggtt acaatccgca ggccgtgcag aataaagtta acgagattct     120

gaatgcgcgt gagatcgcgg atctcactac ggtggcaaac gaagtgattc aaggcaagtg     180

ggggaacggg caggaacggt acaagtcctt ggcaaaccgc ggctacaacc cacaggcagt     240

acagaacaag gtaaacgaaa tcttgaacgc tcgcgaaatt gctgacctta ccacagtagc     300

caatgaggtc attcagggaa aatggggcaa cggtcaagaa cgttataaaa gtttagcgaa     360

tcgagggtat aatccccaag cggttcaaaa taaagtgaat gaattacttt cataa          415


<210> 13
<211> 188
<212> PRT
<213> Cp-7

<220> 
<223> N-terminal domain Cpl-1

<400> 13
Met Val Lys Lys Asn Asp Leu Phe Val Asp Val Ser Ser His Asn Gly 
1               5                   10                  15      
Tyr Asp Ile Thr Gly Ile Leu Glu Gln Met Gly Thr Thr Asn Thr Ile 
            20                  25                  30          
Ile Lys Ile Ser Glu Ser Thr Thr Tyr Leu Asn Pro Cys Leu Ser Ala 
        35                  40                  45              
Gln Val Glu Gln Ser Asn Pro Ile Gly Phe Tyr His Phe Ala Arg Phe 
    50                  55                  60                  
Gly Gly Asp Val Ala Glu Ala Glu Arg Glu Ala Gln Phe Phe Leu Asp 
65                  70                  75                  80  
Asn Val Pro Met Gln Val Lys Tyr Leu Val Leu Asp Tyr Glu Asp Asp 
                85                  90                  95      
Pro Ser Gly Asp Ala Gln Ala Asn Thr Asn Ala Cys Leu Arg Phe Met 
            100                 105                 110         
Gln Met Ile Ala Asp Ala Gly Tyr Lys Pro Ile Tyr Tyr Ser Tyr Lys 
        115                 120                 125             
Pro Phe Thr His Asp Asn Val Asp Tyr Gln Gln Ile Leu Ala Gln Phe 
    130                 135                 140                 
Pro Asn Ser Leu Trp Ile Ala Gly Tyr Gly Leu Asn Asp Gly Thr Ala 
145                 150                 155                 160 
Asn Phe Glu Tyr Phe Pro Ser Met Asp Gly Ile Arg Trp Trp Gln Tyr 
                165                 170                 175     
Ser Ser Asn Pro Phe Asp Lys Asn Ile Val Leu Leu 
            180                 185             

<210> 14
<211> 564
<212> DNA
<213> Cp-7

<220> 
<221> source
<222> 1..564
<223> /mol_type="unassigned DNA"
      /note="N-terminal domain Cpl-1"
      /organism="Cp-7"

<400> 14
atggttaaaa agaatgattt atttgtagat gtttcaagtc acaacggtta cgatataaca      60

ggtatcttgg agcaaatggg aacaactaac accatcatta aaatttctga aagtacgacc     120

tatttaaacc cttgcttgtc tgctcaagtg gagcagtcaa accctattgg cttttatcac     180

ttcgcacgct ttggcggaga cgtagcagaa gccgaaagag aagcgcagtt tttccttgac     240

aacgtgccta tgcaagttaa ataccttgta ttggactacg aggacgaccc aagcggagac     300

gcacaagcga acactaacgc atgcttacgc tttatgcaga tgattgctga cgctggatat     360

aaacctattt attatagtta taaaccgttt acacatgata atgtggacta tcagcaaatc     420

cttgcacagt tccctaattc tctatggatt gcaggctatg gcttaaacga tggtacagct     480

aactttgaat acttcccaag catggacggg ataagatggt ggcagtattc tagtaacccg     540

tttgacaaga atattgtact gtta                                            564


<210> 15
<211> 11
<212> PRT
<213> Cp-7

<220> 
<223> Linker Cpl-1

<400> 15
Asp Asp Glu Glu Asp Asp Lys Pro Lys Thr Ala 
1               5                   10      

<210> 16
<211> 33
<212> DNA
<213> Cp-7

<220> 
<221> source
<222> 1..33
<223> /mol_type="unassigned DNA"
      /note="Linker Cpl-1"
      /organism="Cp-7"

<400> 16
gacgatgaag aagacgacaa gccaaagacc gct                                  33


<210> 17
<211> 342
<212> PRT
<213> Artificial Sequence

<220> 
<223> Artificial Chimera

<400> 17
Met Val Lys Lys Asn Asp Leu Phe Val Asp Val Ala Ser His Gln Gly 
1               5                   10                  15      
Tyr Asp Ile Ser Gly Ile Leu Glu Glu Ala Gly Thr Thr Asn Thr Ile 
            20                  25                  30          
Ile Lys Val Ser Glu Ser Thr Ser Tyr Leu Asn Pro Cys Leu Ser Ala 
        35                  40                  45              
Gln Val Ser Gln Ser Asn Pro Ile Gly Phe Tyr His Phe Ala Trp Phe 
    50                  55                  60                  
Gly Gly Asn Glu Glu Glu Ala Glu Ala Glu Ala Arg Tyr Phe Leu Asp 
65                  70                  75                  80  
Asn Val Pro Thr Gln Val Lys Tyr Leu Val Leu Asp Tyr Glu Asp His 
                85                  90                  95      
Ala Ser Ala Ser Val Gln Arg Asn Thr Thr Ala Cys Leu Arg Phe Met 
            100                 105                 110         
Gln Ile Ile Ala Glu Ala Gly Tyr Thr Pro Ile Tyr Tyr Ser Tyr Lys 
        115                 120                 125             
Pro Phe Thr Leu Asp Asn Val Asp Tyr Gln Gln Ile Leu Ala Gln Phe 
    130                 135                 140                 
Pro Asn Ser Leu Trp Ile Ala Gly Tyr Gly Leu Asn Asp Gly Thr Ala 
145                 150                 155                 160 
Asn Phe Glu Tyr Phe Pro Ser Met Asp Gly Ile Arg Trp Trp Gln Tyr 
                165                 170                 175     
Ser Ser Asn Pro Phe Asp Lys Asn Ile Val Leu Leu Asp Asp Glu Lys 
            180                 185                 190         
Glu Asp Asn Ile Asn Asn Glu Asn Thr Leu Lys Ser Leu Thr Thr Val 
        195                 200                 205             
Ala Asn Glu Val Ile Gln Gly Lys Trp Gly Asn Gly Gln Glu Arg Tyr 
    210                 215                 220                 
Lys Ser Leu Ala Asn Arg Gly Tyr Asn Pro Gln Ala Val Gln Asn Lys 
225                 230                 235                 240 
Val Asn Glu Ile Leu Asn Ala Arg Glu Ile Ala Asp Leu Thr Thr Val 
                245                 250                 255     
Ala Asn Glu Val Ile Gln Gly Lys Trp Gly Asn Gly Gln Glu Arg Tyr 
            260                 265                 270         
Lys Ser Leu Ala Asn Arg Gly Tyr Asn Pro Gln Ala Val Gln Asn Lys 
        275                 280                 285             
Val Asn Glu Ile Leu Asn Ala Arg Glu Ile Ala Asp Leu Thr Thr Val 
    290                 295                 300                 
Ala Asn Glu Val Ile Gln Gly Lys Trp Gly Asn Gly Gln Glu Arg Tyr 
305                 310                 315                 320 
Lys Ser Leu Ala Asn Arg Gly Tyr Asn Pro Gln Ala Val Gln Asn Lys 
                325                 330                 335     
Val Asn Glu Leu Leu Ser 
            340         

<210> 18
<211> 1029
<212> DNA
<213> Artificial Sequence

<220> 
<221> source
<222> 1..1029
<223> /mol_type="unassigned DNA"
      /note="Chimera"
      /organism="Artificial Sequence"

<400> 18
atggttaaaa agaacgacct gttcgttgac gttgcgtctc accagggtta cgacatctct      60

ggtatcctgg aagaagcggg taccaccaac accatcatca aagtttctga atctaccagc     120

tacctgaacc cgtgcctgtc tgcgcaggtt tctcagtcta acccgatcgg tttctaccac     180

ttcgcgtggt tcggtggtaa cgaagaagaa gcggaagcgg aagcgcgtta cttcctggac     240

aacgttccga cccaggttaa atacctggtt ctggactacg aagaccacgc gtctgcgtct     300

gttcagcgta acaccaccgc gtgcctgcgt ttcatgcaga tcatcgcgga agcgggttac     360

accccgatct actactctta caaaccgttc accctggaca acgttgacta ccagcagatc     420

ctggcgcagt tcccgaactc tctgtggatc gcgggttacg gtctgaacga cggtaccgcg     480

aacttcgaat acttcccgtc tatggacggt atccgttggt ggcagtactc ttctaacccg     540

ttcgacaaaa acatcgttct gctggacgac gaaaaagaag acaacatcaa caacgaaaac     600

accctgaaat ctctgacgac cgttgcgaat gaagttatcc aaggtaaatg gggtaatggc     660

caggagcgct acaaatctct ggccaaccgt ggttacaatc cgcaggccgt gcagaataaa     720

gttaacgaga ttctgaatgc gcgtgagatc gcggatctca ctacggtggc aaacgaagtg     780

attcaaggca agtgggggaa cgggcaggaa cggtacaagt ccttggcaaa ccgcggctac     840

aacccacagg cagtacagaa caaggtaaac gaaatcttga acgctcgcga aattgctgac     900

cttaccacag tagccaatga ggtcattcag ggaaaatggg gcaacggtca agaacgttat     960

aaaagtttag cgaatcgagg gtataatccc caagcggttc aaaataaagt gaatgaatta    1020

ctttcataa                                                            1029


<210> 19
<211> 342
<212> PRT
<213> Artificial Sequence

<220> 
<223> Chimera

<400> 19
Met Val Lys Lys Asn Asp Leu Phe Val Asp Val Ala Ser His Gln Gly 
1               5                   10                  15      
Tyr Asp Ile Ser Gly Ile Leu Glu Gln Ala Gly Thr Thr Asn Thr Ile 
            20                  25                  30          
Ile Lys Val Ser Glu Ser Thr Ser Tyr Leu Asn Pro Cys Leu Ser Ala 
        35                  40                  45              
Gln Val Ser Gln Ser Asn Pro Ile Gly Phe Tyr His Phe Ala Trp Phe 
    50                  55                  60                  
Gly Gly Asn Gln Ala Glu Ala Glu Ala Glu Ala Arg Tyr Phe Leu Asp 
65                  70                  75                  80  
Asn Val Pro Thr Gln Val Lys Tyr Leu Val Leu Asp Tyr Glu Asp His 
                85                  90                  95      
Ala Ser Ala Ser Val Gln Arg Asn Thr Thr Ala Cys Leu Arg Phe Met 
            100                 105                 110         
Gln Ile Ile Ala Glu Ala Gly Tyr Thr Pro Ile Tyr Tyr Ser Tyr Lys 
        115                 120                 125             
Pro Phe Thr Leu Asp Asn Val Asp Tyr Gln Gln Ile Leu Ala Gln Phe 
    130                 135                 140                 
Pro Asn Ser Leu Trp Ile Ala Gly Tyr Gly Leu Asn Asp Gly Thr Ala 
145                 150                 155                 160 
Asn Phe Glu Tyr Phe Pro Ser Met Asp Gly Ile Arg Trp Trp Gln Tyr 
                165                 170                 175     
Ser Ser Asn Pro Phe Asp Lys Asn Ile Val Leu Leu Asp Asp Glu Lys 
            180                 185                 190         
Glu Asp Asn Ile Asn Asn Glu Asn Thr Leu Lys Ser Leu Thr Thr Val 
        195                 200                 205             
Ala Asn Glu Val Ile Gln Gly Lys Trp Gly Asn Gly Gln Glu Arg Tyr 
    210                 215                 220                 
Lys Ser Leu Ala Asn Arg Gly Tyr Asn Pro Gln Ala Val Gln Asn Lys 
225                 230                 235                 240 
Val Asn Glu Ile Leu Asn Ala Arg Glu Ile Ala Asp Leu Thr Thr Val 
                245                 250                 255     
Ala Asn Glu Val Ile Gln Gly Lys Trp Gly Asn Gly Gln Glu Arg Tyr 
            260                 265                 270         
Lys Ser Leu Ala Asn Arg Gly Tyr Asn Pro Gln Ala Val Gln Asn Lys 
        275                 280                 285             
Val Asn Glu Ile Leu Asn Ala Arg Glu Ile Ala Asp Leu Thr Thr Val 
    290                 295                 300                 
Ala Asn Glu Val Ile Gln Gly Lys Trp Gly Asn Gly Gln Glu Arg Tyr 
305                 310                 315                 320 
Lys Ser Leu Ala Asn Arg Gly Tyr Asn Pro Gln Ala Val Gln Asn Lys 
                325                 330                 335     
Val Asn Glu Leu Leu Ser 
            340         

<210> 20
<211> 1029
<212> DNA
<213> Artificial Sequence

<220> 
<221> source
<222> 1..1029
<223> /mol_type="unassigned DNA"
      /note="Chimera"
      /organism="Artificial Sequence"

<400> 20
atggttaaaa agaacgacct gttcgttgac gttgcgtctc accagggtta cgacatctct      60

ggtatcctgg aacaggcggg taccaccaac accatcatca aagtttctga atctaccagc     120

tacctgaacc cgtgcctgtc tgcgcaggtt tctcagtcta acccgatcgg tttctaccac     180

ttcgcgtggt tcggtggtaa ccaggcggaa gcggaagcgg aagcgcgtta cttcctggac     240

aacgttccga cccaggttaa atacctggtt ctggactacg aagaccacgc gtctgcgtct     300

gttcagcgta acaccaccgc gtgcctgcgt ttcatgcaga tcatcgcgga agcgggttac     360

accccgatct actactctta caaaccgttc accctggaca acgttgacta ccagcagatc     420

ctggcgcagt tcccgaactc tctgtggatc gcgggttacg gtctgaacga cggtaccgcg     480

aacttcgaat acttcccgtc tatggacggt atccgttggt ggcagtactc ttctaacccg     540

ttcgacaaaa acatcgttct gctggacgac gaaaaagaag acaacatcaa caacgaaaac     600

accctgaaat ctctgacgac cgttgcgaat gaagttatcc aaggtaaatg gggtaatggc     660

caggagcgct acaaatctct ggccaaccgt ggttacaatc cgcaggccgt gcagaataaa     720

gttaacgaga ttctgaatgc gcgtgagatc gcggatctca ctacggtggc aaacgaagtg     780

attcaaggca agtgggggaa cgggcaggaa cggtacaagt ccttggcaaa ccgcggctac     840

aacccacagg cagtacagaa caaggtaaac gaaatcttga acgctcgcga aattgctgac     900

cttaccacag tagccaatga ggtcattcag ggaaaatggg gcaacggtca agaacgttat     960

aaaagtttag cgaatcgagg gtataatccc caagcggttc aaaataaagt gaatgaatta    1020

ctttcataa                                                            1029


<210> 21
<211> 342
<212> PRT
<213> Artificial Sequence

<220> 
<223> Chimera

<400> 21
Met Val Lys Lys Asn Asp Leu Phe Val Asp Val Ala Ser His Gln Gly 
1               5                   10                  15      
Tyr Asp Ile Ser Gly Ile Leu Glu Glu Ala Gly Thr Thr Asn Thr Ile 
            20                  25                  30          
Ile Lys Val Ser Glu Ser Thr Ser Tyr Leu Asn Pro Cys Leu Ser Ala 
        35                  40                  45              
Gln Val Ser Gln Ser Asn Pro Ile Gly Phe Tyr His Phe Ala Trp Phe 
    50                  55                  60                  
Gly Gly Asn Glu Glu Glu Ala Glu Ala Glu Ala Arg Tyr Phe Leu Asp 
65                  70                  75                  80  
Asn Val Pro Thr Gln Val Lys Tyr Leu Val Leu Asp Tyr Glu Asp His 
                85                  90                  95      
Ala Ser Ala Ser Val Gln Arg Asn Thr Thr Ala Cys Leu Arg Phe Met 
            100                 105                 110         
Gln Ile Ile Ala Glu Ala Gly Tyr Thr Pro Ile Tyr Tyr Ser Tyr Lys 
        115                 120                 125             
Pro Phe Thr Leu Asp Asn Val Asp Tyr Gln Gln Ile Leu Ala Gln Phe 
    130                 135                 140                 
Pro Asn Ser Leu Trp Ile Ala Gly Tyr Gly Leu Asn Asp Gly Thr Ala 
145                 150                 155                 160 
Asn Phe Glu Tyr Phe Pro Ser Met Asp Gly Ile Arg Trp Trp Gln Tyr 
                165                 170                 175     
Ser Ser Asn Pro Phe Asp Lys Asn Ile Val Leu Leu Asp Asp Glu Lys 
            180                 185                 190         
Glu Asp Asn Ile Asn Asn Glu Asn Thr Leu Lys Ser Leu Thr Thr Val 
        195                 200                 205             
Ala Asn Glu Val Ile Gln Gly Leu Trp Gly Asn Gly Gln Ala Arg Tyr 
    210                 215                 220                 
Asp Ser Leu Ala Asn Ala Gly Tyr Asp Pro Gln Ala Val Gln Asp Lys 
225                 230                 235                 240 
Val Asn Glu Ile Leu Asn Ala Arg Glu Ile Ala Asp Leu Thr Thr Val 
                245                 250                 255     
Ala Asn Glu Val Ile Gln Gly Leu Trp Gly Asn Gly Gln Ala Arg Tyr 
            260                 265                 270         
Asp Ser Leu Ala Asn Ala Gly Tyr Asp Pro Gln Ala Val Gln Asp Lys 
        275                 280                 285             
Val Asn Glu Ile Leu Asn Ala Arg Glu Ile Ala Asp Leu Thr Thr Val 
    290                 295                 300                 
Ala Asn Glu Val Ile Gln Gly Leu Trp Gly Asn Gly Gln Ala Arg Tyr 
305                 310                 315                 320 
Asp Ser Leu Ala Asn Ala Gly Tyr Asp Pro Gln Ala Val Gln Asp Lys 
                325                 330                 335     
Val Asn Glu Leu Leu Ser 
            340         

<210> 22
<211> 1029
<212> DNA
<213> Artificial Sequence

<220> 
<221> source
<222> 1..1029
<223> /mol_type="unassigned DNA"
      /note="Chimera"
      /organism="Artificial Sequence"

<400> 22
atggttaaaa agaacgacct gttcgttgac gttgcgtctc accagggtta cgacatctct      60

ggtatcctgg aagaagcggg taccaccaac accatcatca aagtttctga atctaccagc     120

tacctgaacc cgtgcctgtc tgcgcaggtt tctcagtcta acccgatcgg tttctaccac     180

ttcgcgtggt tcggtggtaa cgaagaagaa gcggaagcgg aagcgcgtta cttcctggac     240

aacgttccga cccaggttaa atacctggtt ctggactacg aagaccacgc gtctgcgtct     300

gttcagcgta acaccaccgc gtgcctgcgt ttcatgcaga tcatcgcgga agcgggttac     360

accccgatct actactctta caaaccgttc accctggaca acgttgacta ccagcagatc     420

ctggcgcagt tcccgaactc tctgtggatc gcgggttacg gtctgaacga cggtaccgcg     480

aacttcgaat acttcccgtc tatggacggt atccgttggt ggcagtactc ttctaacccg     540

ttcgacaaaa acatcgttct gctggacgac gaaaaagaag acaacatcaa caacgaaaac     600

accctgaaat ctctgacgac cgttgcgaat gaagttatcc aaggtctgtg gggtaatggc     660

caggcgcgct acgattctct ggccaacgcg ggttacgatc cgcaggccgt gcaggataaa     720

gttaacgaga ttctgaatgc gcgtgagatc gcggatctca ctacggtggc aaacgaagtg     780

attcaaggcc tctgggggaa cgggcaggcg cggtacgact ccttggcaaa cgctggctac     840

gacccacagg cagtacagga caaggtaaac gaaatcttga acgctcgcga aattgctgac     900

cttaccacag tagccaacga ggtcattcag ggactttggg gcaacggtca agcgcgttat     960

gacagtttag cgaatgcagg gtatgacccc caagcggttc aagacaaagt gaatgaatta    1020

ctttcataa                                                            1029


<210> 23
<211> 342
<212> PRT
<213> Artificial Sequence

<220> 
<223> Chimera

<400> 23
Met Val Lys Lys Asn Asp Leu Phe Val Asp Val Ser Ser His Asn Gly 
1               5                   10                  15      
Tyr Asp Ile Thr Gly Ile Leu Glu Gln Met Gly Thr Thr Asn Thr Ile 
            20                  25                  30          
Ile Lys Ile Ser Glu Ser Thr Thr Tyr Leu Asn Pro Cys Leu Ser Ala 
        35                  40                  45              
Gln Val Glu Gln Ser Asn Pro Ile Gly Phe Tyr His Phe Ala Arg Phe 
    50                  55                  60                  
Gly Gly Asp Val Ala Glu Ala Glu Arg Glu Ala Gln Phe Phe Leu Asp 
65                  70                  75                  80  
Asn Val Pro Met Gln Val Lys Tyr Leu Val Leu Asp Tyr Glu Asp Asp 
                85                  90                  95      
Pro Ser Gly Asp Ala Gln Ala Asn Thr Asn Ala Cys Leu Arg Phe Met 
            100                 105                 110         
Gln Met Ile Ala Asp Ala Gly Tyr Lys Pro Ile Tyr Tyr Ser Tyr Lys 
        115                 120                 125             
Pro Phe Thr His Asp Asn Val Asp Tyr Gln Gln Ile Leu Ala Gln Phe 
    130                 135                 140                 
Pro Asn Ser Leu Trp Ile Ala Gly Tyr Gly Leu Asn Asp Gly Thr Ala 
145                 150                 155                 160 
Asn Phe Glu Tyr Phe Pro Ser Met Asp Gly Ile Arg Trp Trp Gln Tyr 
                165                 170                 175     
Ser Ser Asn Pro Phe Asp Lys Asn Ile Val Leu Leu Asp Asp Glu Lys 
            180                 185                 190         
Glu Asp Asn Ile Asn Asn Glu Asn Thr Leu Lys Ser Leu Thr Thr Val 
        195                 200                 205             
Ala Asn Glu Val Ile Gln Gly Lys Trp Gly Asn Gly Gln Glu Arg Tyr 
    210                 215                 220                 
Lys Ser Leu Ala Asn Arg Gly Tyr Asn Pro Gln Ala Val Gln Asn Lys 
225                 230                 235                 240 
Val Asn Glu Ile Leu Asn Ala Arg Glu Ile Ala Asp Leu Thr Thr Val 
                245                 250                 255     
Ala Asn Glu Val Ile Gln Gly Lys Trp Gly Asn Gly Gln Glu Arg Tyr 
            260                 265                 270         
Lys Ser Leu Ala Asn Arg Gly Tyr Asn Pro Gln Ala Val Gln Asn Lys 
        275                 280                 285             
Val Asn Glu Ile Leu Asn Ala Arg Glu Ile Ala Asp Leu Thr Thr Val 
    290                 295                 300                 
Ala Asn Glu Val Ile Gln Gly Lys Trp Gly Asn Gly Gln Glu Arg Tyr 
305                 310                 315                 320 
Lys Ser Leu Ala Asn Arg Gly Tyr Asn Pro Gln Ala Val Gln Asn Lys 
                325                 330                 335     
Val Asn Glu Leu Leu Ser 
            340         

<210> 24
<211> 1029
<212> DNA
<213> Artificial Sequence

<220> 
<221> source
<222> 1..1029
<223> /mol_type="unassigned DNA"
      /note="Artificial Chimera"
      /organism="Artificial Sequence"

<400> 24
atggttaaaa agaatgattt atttgtagat gtttcaagtc acaacggtta cgatataaca      60

ggtatcttgg agcaaatggg aacaactaac accatcatta aaatttctga aagtacgacc     120

tatttaaacc cttgcttgtc tgctcaagtg gagcagtcaa accctattgg cttttatcac     180

ttcgcacgct ttggcggaga cgtagcagaa gccgaaagag aagcgcagtt tttccttgac     240

aacgtgccta tgcaagttaa ataccttgta ttggactacg aggacgaccc aagcggagac     300

gcacaagcga acactaacgc atgcttacgc tttatgcaga tgattgctga cgctggatat     360

aaacctattt attatagtta taaaccgttt acacatgata atgtggacta tcagcaaatc     420

cttgcacagt tccctaattc tctatggatt gcaggctatg gcttaaacga tggtacagct     480

aactttgaat acttcccaag catggacggg ataagatggt ggcagtattc tagtaacccg     540

tttgacaaga atattgtact gttagacgac gaaaaagaag acaacatcaa caacgaaaac     600

accctgaaat ctctgacgac cgttgcgaat gaagttatcc aaggtaaatg gggtaatggc     660

caggagcgct acaaatctct ggccaaccgt ggttacaatc cgcaggccgt gcagaataaa     720

gttaacgaga ttctgaatgc gcgtgagatc gcggatctca ctacggtggc aaacgaagtg     780

attcaaggca agtgggggaa cgggcaggaa cggtacaagt ccttggcaaa ccgcggctac     840

aacccacagg cagtacagaa caaggtaaac gaaatcttga acgctcgcga aattgctgac     900

cttaccacag tagccaatga ggtcattcag ggaaaatggg gcaacggtca agaacgttat     960

aaaagtttag cgaatcgagg gtataatccc caagcggttc aaaataaagt gaatgaatta    1020

ctttcataa                                                            1029


<210> 25
<211> 337
<212> PRT
<213> Artificial Sequence

<220> 
<223> Chimera

<400> 25
Met Val Lys Lys Asn Asp Leu Phe Val Asp Val Ser Ser His Asn Gly 
1               5                   10                  15      
Tyr Asp Ile Thr Gly Ile Leu Glu Gln Met Gly Thr Thr Asn Thr Ile 
            20                  25                  30          
Ile Lys Ile Ser Glu Ser Thr Thr Tyr Leu Asn Pro Cys Leu Ser Ala 
        35                  40                  45              
Gln Val Glu Gln Ser Asn Pro Ile Gly Phe Tyr His Phe Ala Arg Phe 
    50                  55                  60                  
Gly Gly Asp Val Ala Glu Ala Glu Arg Glu Ala Gln Phe Phe Leu Asp 
65                  70                  75                  80  
Asn Val Pro Met Gln Val Lys Tyr Leu Val Leu Asp Tyr Glu Asp Asp 
                85                  90                  95      
Pro Ser Gly Asp Ala Gln Ala Asn Thr Asn Ala Cys Leu Arg Phe Met 
            100                 105                 110         
Gln Met Ile Ala Asp Ala Gly Tyr Lys Pro Ile Tyr Tyr Ser Tyr Lys 
        115                 120                 125             
Pro Phe Thr His Asp Asn Val Asp Tyr Gln Gln Ile Leu Ala Gln Phe 
    130                 135                 140                 
Pro Asn Ser Leu Trp Ile Ala Gly Tyr Gly Leu Asn Asp Gly Thr Ala 
145                 150                 155                 160 
Asn Phe Glu Tyr Phe Pro Ser Met Asp Gly Ile Arg Trp Trp Gln Tyr 
                165                 170                 175     
Ser Ser Asn Pro Phe Asp Lys Asn Ile Val Leu Leu Asp Asp Glu Glu 
            180                 185                 190         
Asp Asp Lys Pro Lys Thr Ala Leu Thr Thr Val Ala Asn Glu Val Ile 
        195                 200                 205             
Gln Gly Lys Trp Gly Asn Gly Gln Glu Arg Tyr Lys Ser Leu Ala Asn 
    210                 215                 220                 
Arg Gly Tyr Asn Pro Gln Ala Val Gln Asn Lys Val Asn Glu Ile Leu 
225                 230                 235                 240 
Asn Ala Arg Glu Ile Ala Asp Leu Thr Thr Val Ala Asn Glu Val Ile 
                245                 250                 255     
Gln Gly Lys Trp Gly Asn Gly Gln Glu Arg Tyr Lys Ser Leu Ala Asn 
            260                 265                 270         
Arg Gly Tyr Asn Pro Gln Ala Val Gln Asn Lys Val Asn Glu Ile Leu 
        275                 280                 285             
Asn Ala Arg Glu Ile Ala Asp Leu Thr Thr Val Ala Asn Glu Val Ile 
    290                 295                 300                 
Gln Gly Lys Trp Gly Asn Gly Gln Glu Arg Tyr Lys Ser Leu Ala Asn 
305                 310                 315                 320 
Arg Gly Tyr Asn Pro Gln Ala Val Gln Asn Lys Val Asn Glu Leu Leu 
                325                 330                 335     
Ser 
    

<210> 26
<211> 1014
<212> DNA
<213> Artificial Sequence

<220> 
<221> source
<222> 1..1014
<223> /mol_type="unassigned DNA"
      /note="Chimera"
      /organism="Artificial Sequence"

<400> 26
atggttaaaa agaatgattt atttgtagat gtttcaagtc acaacggtta cgatataaca      60

ggtatcttgg agcaaatggg aacaactaac accatcatta aaatttctga aagtacgacc     120

tatttaaacc cttgcttgtc tgctcaagtg gagcagtcaa accctattgg cttttatcac     180

ttcgcacgct ttggcggaga cgtagcagaa gccgaaagag aagcgcagtt tttccttgac     240

aacgtgccta tgcaagttaa ataccttgta ttggactacg aggacgaccc aagcggagac     300

gcacaagcga acactaacgc atgcttacgc tttatgcaga tgattgctga cgctggatat     360

aaacctattt attatagtta taaaccgttt acacatgata atgtggacta tcagcaaatc     420

cttgcacagt tccctaattc tctatggatt gcaggctatg gcttaaacga tggtacagct     480

aactttgaat acttcccaag catggacggg ataagatggt ggcagtattc tagtaacccg     540

tttgacaaga atattgtact gttagacgat gaagaagacg acaagccaaa gaccgctctg     600

acgaccgttg cgaatgaagt tatccaaggt aaatggggta atggccagga gcgctacaaa     660

tctctggcca accgtggtta caatccgcag gccgtgcaga ataaagttaa cgagattctg     720

aatgcgcgtg agatcgcgga tctcactacg gtggcaaacg aagtgattca aggcaagtgg     780

gggaacgggc aggaacggta caagtccttg gcaaaccgcg gctacaaccc acaggcagta     840

cagaacaagg taaacgaaat cttgaacgct cgcgaaattg ctgaccttac cacagtagcc     900

aatgaggtca ttcagggaaa atggggcaac ggtcaagaac gttataaaag tttagcgaat     960

cgagggtata atccccaagc ggttcaaaat aaagtgaatg aattactttc ataa          1014


