                         SEQUENCE LISTING

<110>  CENTRE NATIONAL DE LA RECHERCHE SCIENTIFIQUE
       MECHALI, Marcel
       COULOMBE, Philippe
 
<120>  Protein involved in DNA replication, and modulation of its 
       activity

<130>  BR71245

<150>  EP 13305725.7
<151>  2013-05-31

<160>  109   

<170>  PatentIn version 3.5

<210>  1
<211>  726
<212>  PRT
<213>  Homo sapiens

<400>  1

Met Ala Gln Thr Val Gln Asn Val Thr Leu Ser Leu Thr Leu Pro Ile 
1               5                   10                  15      


Thr Cys His Ile Cys Leu Gly Lys Val Arg Gln Pro Val Ile Cys Ile 
            20                  25                  30          


Asn Asn His Val Phe Cys Ser Ile Cys Ile Asp Leu Trp Leu Lys Asn 
        35                  40                  45              


Asn Ser Gln Cys Pro Ala Cys Arg Val Pro Ile Thr Pro Glu Asn Pro 
    50                  55                  60                  


Cys Lys Glu Ile Ile Gly Gly Thr Ser Glu Ser Glu Pro Met Leu Ser 
65                  70                  75                  80  


His Thr Val Arg Lys His Leu Arg Lys Thr Arg Leu Glu Leu Leu His 
                85                  90                  95      


Lys Glu Tyr Glu Asp Glu Ile Asp Cys Leu Gln Lys Glu Val Glu Glu 
            100                 105                 110         


Leu Lys Ser Lys Asn Leu Ser Leu Glu Ser Gln Ile Lys Thr Ile Leu 
        115                 120                 125             


Asp Pro Leu Thr Leu Val Gln Gly Asn Gln Asn Glu Asp Lys His Leu 
    130                 135                 140                 


Val Thr Asp Asn Pro Ser Lys Ile Asn Pro Glu Thr Val Ala Glu Trp 
145                 150                 155                 160 


Lys Lys Lys Leu Arg Thr Ala Asn Glu Ile Tyr Glu Lys Val Lys Asp 
                165                 170                 175     


Asp Val Asp Lys Leu Lys Glu Ala Asn Lys Lys Leu Lys Leu Glu Asn 
            180                 185                 190         


Gly Gly Leu Val Arg Glu Asn Leu Arg Leu Lys Ala Glu Val Asp Asn 
        195                 200                 205             


Arg Ser Pro Gln Lys Phe Gly Arg Phe Ala Val Ala Ala Leu Gln Ser 
    210                 215                 220                 


Lys Val Glu Gln Tyr Glu Arg Glu Thr Asn Arg Leu Lys Lys Ala Leu 
225                 230                 235                 240 


Glu Arg Ser Asp Lys Tyr Ile Glu Glu Leu Glu Ser Gln Val Ala Gln 
                245                 250                 255     


Leu Lys Asn Ser Ser Glu Glu Lys Glu Ala Met Asn Ser Ile Cys Gln 
            260                 265                 270         


Thr Ala Leu Ser Ala Asp Gly Lys Gly Ser Lys Gly Ser Glu Glu Asp 
        275                 280                 285             


Val Val Ser Lys Asn Gln Gly Asp Ser Ala Arg Lys Gln Pro Gly Ser 
    290                 295                 300                 


Ser Thr Ser Ser Ser Ser His Leu Ala Lys Pro Ser Ser Ser Arg Leu 
305                 310                 315                 320 


Cys Asp Thr Ser Ser Ala Arg Gln Glu Ser Thr Ser Lys Ala Asp Leu 
                325                 330                 335     


Asn Cys Ser Lys Asn Lys Asp Leu Tyr Gln Glu Gln Val Glu Val Met 
            340                 345                 350         


Leu Asp Val Thr Asp Thr Ser Met Asp Thr Tyr Leu Glu Arg Glu Trp 
        355                 360                 365             


Gly Asn Lys Pro Ser Asp Cys Val Pro Tyr Lys Asp Glu Glu Leu Tyr 
    370                 375                 380                 


Asp Leu Pro Ala Pro Cys Thr Pro Leu Ser Leu Ser Cys Leu Gln Leu 
385                 390                 395                 400 


Ser Thr Pro Glu Asn Arg Glu Ser Ser Val Val Gln Ala Gly Gly Ser 
                405                 410                 415     


Lys Lys His Ser Asn His Leu Arg Lys Leu Val Phe Asp Asp Phe Cys 
            420                 425                 430         


Asp Ser Ser Asn Val Ser Asn Lys Asp Ser Ser Glu Asp Asp Ile Ser 
        435                 440                 445             


Arg Ser Glu Asn Glu Lys Lys Ser Glu Cys Phe Ser Ser Pro Lys Thr 
    450                 455                 460                 


Gly Phe Trp Asp Cys Cys Ser Thr Ser Tyr Ala Gln Asn Leu Asp Phe 
465                 470                 475                 480 


Glu Ser Ser Glu Gly Asn Thr Ile Ala Asn Ser Val Gly Glu Ile Ser 
                485                 490                 495     


Ser Lys Leu Ser Glu Lys Ser Gly Leu Cys Leu Ser Lys Arg Leu Asn 
            500                 505                 510         


Ser Ile Arg Ser Phe Glu Met Asn Arg Thr Arg Thr Ser Ser Glu Ala 
        515                 520                 525             


Ser Met Asp Ala Ala Tyr Leu Asp Lys Ile Ser Glu Leu Asp Ser Met 
    530                 535                 540                 


Met Ser Glu Ser Asp Asn Ser Lys Ser Pro Cys Asn Asn Gly Phe Lys 
545                 550                 555                 560 


Ser Leu Asp Leu Asp Gly Leu Ser Lys Ser Ser Gln Gly Ser Glu Phe 
                565                 570                 575     


Leu Glu Glu Pro Asp Lys Leu Glu Glu Lys Thr Glu Leu Asn Leu Ser 
            580                 585                 590         


Lys Gly Ser Leu Thr Asn Asp Gln Leu Glu Asn Gly Ser Glu Trp Lys 
        595                 600                 605             


Pro Thr Ser Phe Phe Leu Leu Ser Pro Ser Asp Gln Glu Met Asn Glu 
    610                 615                 620                 


Asp Phe Ser Leu His Ser Ser Ser Cys Pro Val Thr Asn Glu Ile Lys 
625                 630                 635                 640 


Pro Pro Ser Cys Leu Phe Gln Thr Glu Phe Ser Gln Gly Ile Leu Leu 
                645                 650                 655     


Ser Ser Ser His Arg Leu Phe Glu Asp Gln Arg Phe Gly Ser Ser Leu 
            660                 665                 670         


Phe Lys Met Ser Ser Glu Met His Ser Leu His Asn His Leu Gln Ser 
        675                 680                 685             


Pro Trp Ser Thr Ser Phe Val Pro Glu Lys Arg Asn Lys Asn Val Asn 
    690                 695                 700                 


Gln Ser Thr Lys Arg Lys Ile Gln Ser Ser Leu Ser Ser Ala Ser Pro 
705                 710                 715                 720 


Ser Lys Ala Thr Lys Ser 
                725     


<210>  2
<211>  726
<212>  PRT
<213>  Pan troglodytes

<400>  2

Met Ala Gln Thr Val Gln Asn Val Thr Leu Ser Leu Thr Leu Pro Ile 
1               5                   10                  15      


Thr Cys His Ile Cys Leu Gly Lys Val Arg Gln Pro Val Ile Cys Ile 
            20                  25                  30          


Asn Asn His Val Phe Cys Ser Ile Cys Ile Asp Leu Trp Leu Lys Asn 
        35                  40                  45              


Asn Ser Gln Cys Pro Ala Cys Arg Val Pro Ile Thr Pro Glu Asn Pro 
    50                  55                  60                  


Cys Lys Glu Ile Ile Gly Gly Thr Ser Glu Ser Glu Pro Met Leu Ser 
65                  70                  75                  80  


His Thr Val Arg Lys His Leu Arg Lys Thr Arg Leu Glu Leu Leu His 
                85                  90                  95      


Lys Glu Tyr Glu Asp Glu Ile Asp Cys Leu Gln Lys Glu Val Glu Glu 
            100                 105                 110         


Leu Lys Ser Lys Asn Leu Ser Leu Glu Ser Gln Ile Lys Thr Ile Leu 
        115                 120                 125             


Asp Pro Leu Thr Leu Val Gln Gly Asn Gln Asn Glu Asp Lys His Leu 
    130                 135                 140                 


Val Thr Asp Asn Pro Ser Lys Ile Asn Pro Glu Thr Val Ala Glu Trp 
145                 150                 155                 160 


Lys Lys Lys Leu Arg Thr Ala Asn Glu Ile Tyr Glu Lys Val Lys Asp 
                165                 170                 175     


Asp Val Asp Lys Leu Lys Glu Ala Asn Lys Lys Leu Lys Leu Glu Asn 
            180                 185                 190         


Gly Gly Leu Val Arg Glu Asn Leu Arg Leu Lys Ala Glu Val Asp Asn 
        195                 200                 205             


Arg Ser Pro Gln Lys Phe Gly Arg Phe Ala Val Ala Ala Leu Gln Ser 
    210                 215                 220                 


Lys Val Glu Gln Tyr Glu Arg Glu Thr Asn Arg Leu Lys Lys Ala Leu 
225                 230                 235                 240 


Glu Arg Ser Asp Lys Tyr Ile Glu Glu Leu Glu Ser Gln Val Ala Gln 
                245                 250                 255     


Leu Lys Asn Ser Ser Glu Glu Lys Glu Ala Met Asn Ser Ile Cys Lys 
            260                 265                 270         


Thr Ala Leu Ser Ala Asp Gly Lys Gly Ser Lys Gly Ser Glu Glu Asp 
        275                 280                 285             


Val Ala Ser Lys Asn Gln Gly Asp Ser Ala Arg Lys Gln Pro Gly Ser 
    290                 295                 300                 


Ser Thr Ser Ser Ser Ser His Leu Ala Lys Pro Ser Ser Ser Arg Leu 
305                 310                 315                 320 


Cys Asp Thr Ser Ser Ala Arg Gln Glu Ser Thr Ser Lys Ala Asp Leu 
                325                 330                 335     


Asn Cys Ser Lys Asn Lys Asp Leu Tyr Gln Glu Gln Val Glu Val Met 
            340                 345                 350         


Leu Asp Val Thr Asp Thr Ser Met Asp Thr Tyr Leu Glu Arg Glu Trp 
        355                 360                 365             


Gly Asn Lys Pro Ser Asp Cys Val Pro Tyr Lys Asp Glu Glu Leu Tyr 
    370                 375                 380                 


Asp Leu Pro Ala Pro Cys Thr Pro Leu Ser Leu Ser Cys Leu Gln Leu 
385                 390                 395                 400 


Ser Thr Pro Glu Asn Arg Glu Ser Ser Val Val Gln Ala Gly Gly Ser 
                405                 410                 415     


Lys Lys His Ser Asn His Leu Arg Lys Leu Val Phe Asp Asp Phe Cys 
            420                 425                 430         


Asp Ser Ser Asn Val Ser Asn Lys Asp Ser Ser Glu Asp Asp Ile Ser 
        435                 440                 445             


Arg Ser Glu Asn Glu Lys Lys Ser Glu Cys Phe Ser Ser Pro Lys Thr 
    450                 455                 460                 


Gly Phe Trp Asp Cys Cys Ser Thr Ser Tyr Ala Gln Asn Leu Asp Phe 
465                 470                 475                 480 


Glu Ser Ser Glu Gly Asn Thr Ile Ala Asn Ser Val Gly Glu Ile Ser 
                485                 490                 495     


Ser Lys Leu Ser Glu Lys Ser Gly Leu Cys Leu Ser Lys Arg Leu Asn 
            500                 505                 510         


Ser Ile Arg Ser Phe Glu Met Asn Arg Thr Arg Thr Ser Ser Glu Ala 
        515                 520                 525             


Ser Met Asp Ala Ala Tyr Leu Asp Lys Ile Ser Glu Leu Asp Ser Met 
    530                 535                 540                 


Met Ser Glu Ser Asp Asn Ser Lys Ser Pro Cys Asn Asn Gly Phe Lys 
545                 550                 555                 560 


Ser Leu Asp Leu Asp Gly Leu Ser Lys Ser Ser Gln Gly Ser Glu Phe 
                565                 570                 575     


Leu Glu Glu Pro Asp Lys Leu Glu Glu Lys Thr Glu Leu Asn Leu Ser 
            580                 585                 590         


Lys Gly Ser Leu Thr Asn Asp Gln Leu Glu Asn Gly Ser Glu Trp Lys 
        595                 600                 605             


Pro Thr Ser Phe Phe Leu Leu Ser Pro Ser Asp Gln Glu Met Asn Glu 
    610                 615                 620                 


Asp Phe Ser Leu His Ser Ser Ser Cys Pro Val Thr Asn Glu Ile Lys 
625                 630                 635                 640 


Pro Pro Ser Cys Leu Phe Gln Thr Glu Phe Ser Gln Gly Ile Leu Leu 
                645                 650                 655     


Ser Ser Ser His Arg Leu Phe Glu Asp Gln Arg Phe Gly Ser Ser Leu 
            660                 665                 670         


Phe Lys Met Ser Ser Glu Met His Ser Leu His Asn His Leu Gln Ser 
        675                 680                 685             


Pro Trp Ser Thr Ser Phe Val Pro Glu Lys Arg Asn Lys Asn Val Asn 
    690                 695                 700                 


Gln Ser Thr Lys Arg Lys Ile Gln Ser Ser Leu Ser Asn Ala Ser Pro 
705                 710                 715                 720 


Ser Lys Ala Thr Lys Ser 
                725     


<210>  3
<211>  726
<212>  PRT
<213>  Nomascus leucogenys

<400>  3

Met Ala Gln Thr Val Gln Asn Val Thr Leu Ser Leu Thr Leu Pro Ile 
1               5                   10                  15      


Thr Cys His Ile Cys Leu Gly Lys Val Arg Gln Pro Val Ile Cys Ile 
            20                  25                  30          


Asn Asn His Val Phe Cys Ser Ile Cys Ile Asp Leu Trp Leu Lys Asn 
        35                  40                  45              


Asn Ser Gln Cys Pro Ala Cys Arg Val Pro Ile Thr Pro Glu Asn Pro 
    50                  55                  60                  


Cys Lys Glu Ile Ile Gly Gly Thr Ser Glu Ser Glu Pro Met Leu Ser 
65                  70                  75                  80  


His Thr Val Arg Lys His Leu Arg Lys Thr Arg Leu Glu Leu Leu His 
                85                  90                  95      


Lys Glu Tyr Glu Asp Glu Ile Asp Cys Leu Gln Lys Glu Val Glu Glu 
            100                 105                 110         


Leu Lys Ser Lys Asn Leu Ser Leu Glu Ser Gln Ile Lys Thr Ile Leu 
        115                 120                 125             


Asp Pro Leu Thr Leu Val Gln Gly Asn Gln Asn Glu Asp Lys His Leu 
    130                 135                 140                 


Val Thr Asp Asn Pro Ser Lys Ile Asn Pro Glu Thr Val Ala Glu Trp 
145                 150                 155                 160 


Lys Lys Lys Leu Arg Thr Ala Asn Glu Ile Tyr Glu Lys Val Lys Asp 
                165                 170                 175     


Asp Val Asp Lys Leu Lys Glu Ala Asn Lys Lys Leu Lys Leu Glu Asn 
            180                 185                 190         


Gly Gly Leu Val Arg Glu Asn Leu Arg Leu Lys Ala Glu Val Asp Asn 
        195                 200                 205             


Arg Ser Pro Gln Lys Phe Gly Arg Phe Ala Val Ala Ala Leu Gln Ser 
    210                 215                 220                 


Lys Val Glu Gln Tyr Glu Arg Glu Thr Asn Arg Leu Lys Lys Ala Leu 
225                 230                 235                 240 


Glu Arg Ser Asp Lys Tyr Ile Glu Glu Leu Glu Ser Gln Val Ala Gln 
                245                 250                 255     


Leu Lys Asn Ser Ser Glu Glu Lys Glu Ala Met Asn Ser Ile Cys Gln 
            260                 265                 270         


Thr Ala Leu Ser Ala Asp Gly Lys Gly Ser Lys Gly Ser Glu Glu Asp 
        275                 280                 285             


Val Ala Ser Lys Asn Gln Gly Asp Ser Ala Arg Lys Gln Pro Gly Ser 
    290                 295                 300                 


Ser Thr Ser Ser Ser Ser His Leu Ala Lys Pro Ser Ser Ser Arg Leu 
305                 310                 315                 320 


Cys Asp Thr Ser Ser Ala Arg Gln Glu Ser Thr Ser Lys Ala Glu Leu 
                325                 330                 335     


Asn Cys Ser Lys Asn Lys Asp Leu Tyr Gln Glu Gln Val Glu Val Met 
            340                 345                 350         


Leu Asp Val Thr Asp Thr Ser Met Asp Thr Tyr Leu Glu Arg Glu Trp 
        355                 360                 365             


Gly Asn Lys Pro Ser Asp Cys Val Pro Tyr Lys Asp Glu Glu Leu Tyr 
    370                 375                 380                 


Asp Leu Pro Ala Pro Cys Thr Pro Leu Ser Leu Ser Cys Leu Gln Leu 
385                 390                 395                 400 


Ser Thr Pro Glu Asn Arg Glu Ser Ser Val Val Gln Ala Gly Gly Ser 
                405                 410                 415     


Lys Lys His Ser Asn His Leu Arg Lys Leu Val Phe Asp Asp Phe Cys 
            420                 425                 430         


Asp Ser Ser Asn Val Ser Asn Lys Asp Ser Ser Glu Asp Asp Ile Ser 
        435                 440                 445             


Arg Ser Glu Asn Glu Lys Lys Ser Glu Cys Phe Ser Ser Pro Lys Thr 
    450                 455                 460                 


Gly Phe Trp Asp Cys Cys Ser Thr Ser Tyr Ala Gln Asn Leu Asp Phe 
465                 470                 475                 480 


Glu Ser Ser Glu Gly Asn Thr Ile Ala Asn Ser Val Gly Glu Ile Ser 
                485                 490                 495     


Ser Lys Leu Ser Glu Lys Ser Gly Ser Cys Val Ser Lys Arg Leu Asn 
            500                 505                 510         


Ser Ile Arg Ser Phe Glu Met Asn Arg Thr Arg Thr Ser Ser Glu Ala 
        515                 520                 525             


Ser Met Asp Ala Ala Tyr Leu Asp Lys Ile Ser Glu Leu Asp Ser Met 
    530                 535                 540                 


Met Ser Glu Ser Asp Asn Ser Lys Ser Pro Cys Asn Asn Gly Phe Lys 
545                 550                 555                 560 


Ser Leu Asp Leu Asp Gly Leu Ser Lys Ser Ser Gln Gly Ser Glu Phe 
                565                 570                 575     


Leu Glu Glu Pro Asp Lys Leu Glu Glu Lys Thr Glu Leu Asn Leu Ser 
            580                 585                 590         


Lys Gly Ser Leu Thr Asn Asp Gln Leu Glu Asn Gly Ser Glu Trp Lys 
        595                 600                 605             


Pro Thr Ser Phe Phe Leu Leu Ser Pro Ser Asp Gln Glu Met Asn Glu 
    610                 615                 620                 


Asp Phe Ser Leu His Ser Ser Ser Cys Pro Val Thr Asn Glu Ile Lys 
625                 630                 635                 640 


Pro Pro Ser Cys Leu Phe Gln Thr Glu Phe Ser Gln Gly Ile Leu Leu 
                645                 650                 655     


Ser Ser Ser His Arg Leu Phe Glu Asp Gln Arg Phe Gly Ser Ser Leu 
            660                 665                 670         


Phe Lys Met Ser Ser Glu Met His Ser Leu His Asn His Leu Gln Ser 
        675                 680                 685             


Pro Trp Ser Thr Ser Phe Val Pro Glu Lys Arg Asn Lys Asn Val Asn 
    690                 695                 700                 


Gln Ser Thr Lys Arg Lys Ile Gln Ser Ser Leu Ser Asn Ala Ser Pro 
705                 710                 715                 720 


Ser Lys Ala Thr Lys Ser 
                725     


<210>  4
<211>  726
<212>  PRT
<213>  Gorilla gorilla

<400>  4

Met Ala Gln Thr Val Gln Asn Val Thr Leu Ser Leu Thr Leu Pro Ile 
1               5                   10                  15      


Thr Cys His Ile Cys Leu Gly Lys Val Arg Gln Pro Val Ile Cys Ile 
            20                  25                  30          


Asn Asn His Val Phe Cys Ser Ile Cys Ile Asp Leu Trp Leu Lys Asn 
        35                  40                  45              


Asn Ser Gln Cys Pro Ala Cys Arg Val Pro Ile Thr Pro Glu Asn Pro 
    50                  55                  60                  


Cys Lys Glu Ile Ile Gly Gly Thr Ser Glu Ser Glu Pro Met Leu Ser 
65                  70                  75                  80  


His Thr Val Arg Lys His Leu Arg Lys Thr Arg Leu Glu Leu Leu His 
                85                  90                  95      


Lys Glu Tyr Glu Asp Glu Ile Asp Cys Leu Gln Lys Glu Val Glu Glu 
            100                 105                 110         


Leu Lys Ser Lys Asn Leu Gly Leu Glu Ser Gln Ile Lys Thr Ile Leu 
        115                 120                 125             


Asp Pro Leu Thr Leu Val Gln Gly Asn Gln Asn Glu Asp Lys His Leu 
    130                 135                 140                 


Val Thr Asp Asn Pro Ser Lys Ile Asn Pro Glu Thr Val Ala Glu Trp 
145                 150                 155                 160 


Lys Lys Lys Leu Arg Thr Ala Asn Glu Ile Tyr Glu Lys Val Lys Asp 
                165                 170                 175     


Asp Val Asp Lys Leu Lys Glu Ala Asn Lys Lys Leu Lys Leu Glu Asn 
            180                 185                 190         


Gly Gly Leu Val Arg Glu Asn Leu Arg Leu Lys Ala Glu Val Asp Asn 
        195                 200                 205             


Arg Ser Pro Gln Lys Phe Gly Arg Phe Ala Val Ala Ala Leu Gln Ser 
    210                 215                 220                 


Lys Val Glu Gln Tyr Glu Arg Glu Thr Asn Arg Leu Lys Lys Ala Leu 
225                 230                 235                 240 


Glu Arg Ser Asp Lys Tyr Ile Glu Glu Leu Glu Ser Gln Val Ala Gln 
                245                 250                 255     


Leu Lys Asn Ser Ser Glu Glu Lys Glu Ala Met Asn Ser Ile Cys Gln 
            260                 265                 270         


Thr Ala Leu Ser Ala Asp Gly Lys Gly Ser Lys Gly Ser Glu Glu Asp 
        275                 280                 285             


Val Ala Ser Lys Asn Gln Gly Asp Ser Ala Arg Lys Gln Pro Gly Ser 
    290                 295                 300                 


Ser Thr Ser Ser Ser Ser His Leu Ala Lys Pro Ser Ser Ser Arg Leu 
305                 310                 315                 320 


Cys Asp Thr Ser Ser Ala Arg Gln Glu Ser Thr Ser Lys Ala Glu Leu 
                325                 330                 335     


Asn Cys Ser Lys Asn Lys Asp Leu Tyr Gln Glu Gln Val Glu Val Met 
            340                 345                 350         


Leu Asp Val Thr Asp Thr Ser Met Asp Thr Tyr Leu Glu Arg Glu Trp 
        355                 360                 365             


Gly Asn Lys Pro Ser Asp Cys Val Pro Tyr Lys Asp Glu Glu Leu Tyr 
    370                 375                 380                 


Asp Leu Pro Ala Pro Cys Thr Pro Leu Ser Leu Ser Cys Leu Gln Leu 
385                 390                 395                 400 


Ser Thr Pro Glu Asn Arg Glu Ser Ser Val Val Gln Ala Gly Gly Ser 
                405                 410                 415     


Lys Lys His Ser Asn His Phe Arg Lys Leu Val Phe Asp Asp Phe Cys 
            420                 425                 430         


Asp Ser Ser Asn Val Ser Asn Lys Asp Ser Ser Glu Asp Asp Ile Ser 
        435                 440                 445             


Arg Ser Glu Asn Glu Lys Lys Ser Glu Cys Phe Ser Ser Pro Lys Thr 
    450                 455                 460                 


Gly Phe Trp Asp Cys Cys Ser Thr Ser Tyr Ala Gln Asn Leu Asp Phe 
465                 470                 475                 480 


Glu Ser Ser Glu Gly Asn Thr Ile Ala Asn Ser Val Gly Glu Ile Ser 
                485                 490                 495     


Ser Lys Leu Ser Glu Lys Ser Gly Ser Cys Leu Ser Lys Arg Leu Asn 
            500                 505                 510         


Ser Ile Arg Ser Phe Glu Met Asn Arg Thr Arg Thr Ser Ser Glu Ala 
        515                 520                 525             


Ser Met Asp Ala Ala Tyr Leu Asp Lys Ile Ser Glu Leu Asp Ser Met 
    530                 535                 540                 


Met Ser Glu Ser Asp Asn Ser Lys Ser Pro Cys Asn Asn Gly Phe Lys 
545                 550                 555                 560 


Ser Leu Asp Leu Asp Gly Leu Ser Lys Ser Ser Gln Gly Ser Glu Phe 
                565                 570                 575     


Leu Glu Glu Pro Asp Lys Leu Glu Glu Lys Thr Glu Leu Asn Leu Ser 
            580                 585                 590         


Lys Gly Ser Leu Thr Asn Asp Gln Leu Glu Asn Gly Ser Glu Trp Lys 
        595                 600                 605             


Pro Thr Ser Phe Phe Leu Leu Ser Pro Ser Asp Gln Glu Met Asn Glu 
    610                 615                 620                 


Asp Phe Ser Leu His Ser Ser Ser Cys Pro Val Thr Asn Glu Ile Lys 
625                 630                 635                 640 


Pro Pro Ser Cys Leu Phe Gln Ala Glu Phe Ser Gln Gly Ile Leu Leu 
                645                 650                 655     


Ser Ser Ser His Arg Leu Phe Glu Asp Gln Arg Phe Gly Ser Ser Leu 
            660                 665                 670         


Phe Lys Met Ser Ser Glu Met Tyr Ser Leu His Asn His Leu Gln Ser 
        675                 680                 685             


Pro Trp Ser Ala Ser Phe Val Pro Glu Lys Arg Asn Lys Asn Val Asn 
    690                 695                 700                 


Gln Ser Thr Lys Arg Lys Ile Gln Ser Ser Leu Ser Asn Ala Ser Pro 
705                 710                 715                 720 


Ser Lys Ala Thr Lys Ser 
                725     


<210>  5
<211>  726
<212>  PRT
<213>  Pongo abelii

<400>  5

Met Ala Gln Thr Val Gln Asn Val Thr Leu Ser Leu Thr Leu Pro Ile 
1               5                   10                  15      


Thr Cys His Ile Cys Leu Gly Lys Val Arg Gln Pro Val Ile Cys Ile 
            20                  25                  30          


Asn Asn His Val Phe Cys Ser Ile Cys Ile Asp Leu Trp Leu Lys Asn 
        35                  40                  45              


Asn Ser Gln Cys Pro Ala Cys Arg Val Pro Ile Thr Pro Glu Asn Pro 
    50                  55                  60                  


Cys Lys Glu Ile Ile Gly Gly Thr Ser Glu Ser Glu Pro Met Leu Ser 
65                  70                  75                  80  


His Thr Val Arg Lys His Leu Arg Lys Thr Arg Leu Glu Leu Leu His 
                85                  90                  95      


Lys Glu Tyr Glu Asp Glu Ile Asp Cys Leu Gln Lys Glu Val Glu Glu 
            100                 105                 110         


Leu Lys Ser Lys Asn Leu Ser Leu Glu Ser Gln Ile Lys Thr Ile Leu 
        115                 120                 125             


Asp Pro Leu Thr Leu Val Gln Gly Asn Gln Asn Glu Asp Lys His Leu 
    130                 135                 140                 


Val Thr Asp Asn Pro Ser Lys Ile Asn Pro Glu Thr Val Ala Glu Trp 
145                 150                 155                 160 


Lys Lys Lys Leu Arg Thr Ala Asn Glu Ile Tyr Glu Lys Val Lys Asp 
                165                 170                 175     


Asp Val Asp Lys Leu Lys Glu Ala Asn Lys Lys Leu Lys Leu Glu Asn 
            180                 185                 190         


Gly Gly Leu Val Arg Glu Asn Leu Arg Leu Lys Ala Glu Val Asp Asn 
        195                 200                 205             


Arg Ser Pro Gln Lys Phe Gly Arg Phe Ala Val Ala Ala Leu Gln Ser 
    210                 215                 220                 


Lys Val Glu Gln Tyr Glu Arg Glu Thr Ser Arg Leu Lys Lys Ala Leu 
225                 230                 235                 240 


Glu Arg Ser Asp Lys Tyr Ile Glu Glu Leu Glu Ser Gln Val Ala Gln 
                245                 250                 255     


Leu Lys Asn Ser Ser Glu Glu Lys Glu Ala Met Asn Ser Ile Cys Gln 
            260                 265                 270         


Thr Ala Leu Pro Ala Asp Gly Lys Gly Ser Lys Gly Ser Glu Glu Asp 
        275                 280                 285             


Val Ala Ser Lys Asn Gln Gly Asp Ser Ala Arg Lys Gln Pro Ser Ser 
    290                 295                 300                 


Ser Thr Ser Ser Ser Ser His Leu Ala Lys Pro Ser Ser Ser Arg Leu 
305                 310                 315                 320 


Cys Asp Thr Ser Ser Ala Arg Gln Glu Ser Thr Ser Lys Ala Glu Leu 
                325                 330                 335     


Asn Cys Ser Lys Asn Lys Asp Leu Tyr Gln Glu Gln Val Glu Val Met 
            340                 345                 350         


Leu Asp Val Thr Asp Thr Ser Met Asp Thr Tyr Leu Glu Arg Glu Trp 
        355                 360                 365             


Gly Asn Lys Pro Ser Asp Cys Val Pro Tyr Lys Asp Glu Glu Leu Tyr 
    370                 375                 380                 


Asp Leu Pro Ala Pro Cys Thr Pro Leu Ser Leu Ser Cys Leu Gln Leu 
385                 390                 395                 400 


Ser Thr Pro Glu Asn Arg Glu Ser Pro Val Val Gln Ala Gly Gly Ser 
                405                 410                 415     


Lys Lys His Ser Asn His Leu Arg Lys Leu Val Phe Asp Asp Phe Cys 
            420                 425                 430         


Asp Ser Ser Asn Val Ser Asn Lys Asp Ser Ser Glu Asp Asp Ile Ser 
        435                 440                 445             


Arg Ser Glu Asn Glu Lys Lys Ser Glu Cys Phe Ser Ser Pro Lys Thr 
    450                 455                 460                 


Ala Phe Trp Asp Cys Cys Ser Thr Ser Tyr Ala Gln Asn Leu Asp Phe 
465                 470                 475                 480 


Glu Ser Ser Glu Gly Asn Thr Ile Ala Asn Ser Val Gly Glu Ile Ser 
                485                 490                 495     


Ser Lys Leu Ser Glu Lys Ser Gly Ser Cys Val Ser Lys Arg Leu Asn 
            500                 505                 510         


Ser Ile Arg Ser Phe Glu Met Asn Arg Thr Arg Thr Ser Ser Glu Ala 
        515                 520                 525             


Ser Met Asp Ala Ala Tyr Leu Asp Lys Ile Ser Glu Leu Asp Ser Met 
    530                 535                 540                 


Met Ser Glu Ser Asp Asn Ser Lys Ser Pro Cys Asn Asn Gly Phe Lys 
545                 550                 555                 560 


Ser Leu Asp Leu Asp Gly Leu Ser Lys Ser Ser Gln Gly Ser Glu Phe 
                565                 570                 575     


Leu Glu Glu Pro Asp Lys Leu Glu Glu Lys Thr Glu Leu Asn Leu Ser 
            580                 585                 590         


Lys Gly Ser Leu Thr Asn Asp Gln Leu Glu Asn Gly Ser Glu Trp Lys 
        595                 600                 605             


Pro Thr Ser Phe Phe Leu Leu Ser Pro Ser Asp Gln Glu Met Asn Glu 
    610                 615                 620                 


Asp Phe Ser Leu His Ser Ser Ser Cys Pro Val Thr Asn Glu Ile Lys 
625                 630                 635                 640 


Pro Pro Ser Cys Leu Phe Gln Thr Glu Phe Ser Gln Gly Ile Leu Leu 
                645                 650                 655     


Ser Ser Ser His Arg Leu Phe Glu Asp Gln Arg Phe Gly Ser Ser Leu 
            660                 665                 670         


Phe Lys Met Ser Ser Glu Met His Ser Leu His Asn His Leu Gln Ser 
        675                 680                 685             


Pro Trp Ser Thr Ser Phe Val Pro Glu Lys Arg Asn Lys Asn Val Asn 
    690                 695                 700                 


Gln Ser Thr Lys Arg Lys Ile Gln Ser Ser Leu Ser Asn Ala Ser Pro 
705                 710                 715                 720 


Ser Lys Ala Thr Lys Ser 
                725     


<210>  6
<211>  726
<212>  PRT
<213>  Macaca fascicularis

<400>  6

Met Ala Gln Thr Val Gln Asn Val Thr Leu Ser Leu Thr Leu Pro Ile 
1               5                   10                  15      


Thr Cys His Ile Cys Leu Gly Lys Val Arg Gln Pro Val Ile Cys Ile 
            20                  25                  30          


Asn Asn His Val Phe Cys Ser Ile Cys Ile Asp Leu Trp Leu Lys Asn 
        35                  40                  45              


Asn Ser Gln Cys Pro Ala Cys Arg Val Pro Ile Thr Pro Glu Asn Pro 
    50                  55                  60                  


Cys Lys Glu Ile Ile Gly Gly Thr Ser Glu Ser Glu Pro Thr Leu Ser 
65                  70                  75                  80  


His Thr Val Arg Lys His Leu Arg Lys Thr Arg Leu Glu Leu Leu His 
                85                  90                  95      


Lys Glu Tyr Glu Asp Glu Ile Asp Cys Leu Gln Lys Glu Val Glu Glu 
            100                 105                 110         


Leu Lys Ser Lys Asn Leu Ser Leu Glu Ser Gln Ile Lys Thr Ile Leu 
        115                 120                 125             


Asp Pro Leu Thr Leu Val Gln Gly Asn Gln Asn Glu Asp Lys His Leu 
    130                 135                 140                 


Val Thr Asp Asn Pro Thr Lys Ile Asn Pro Glu Thr Val Ala Glu Trp 
145                 150                 155                 160 


Lys Lys Lys Leu Arg Thr Ala Asn Glu Ile Tyr Glu Lys Val Lys Asp 
                165                 170                 175     


Asp Val Asp Lys Leu Lys Glu Ala Asn Lys Lys Leu Lys Leu Glu Asn 
            180                 185                 190         


Gly Gly Leu Val Arg Glu Asn Leu Arg Leu Lys Ala Glu Val Asp Asn 
        195                 200                 205             


Arg Ser Pro Gln Lys Phe Gly Arg Phe Ala Val Ala Ala Leu Gln Ser 
    210                 215                 220                 


Lys Val Glu Gln Tyr Glu Arg Glu Thr Asn Arg Leu Lys Lys Ala Leu 
225                 230                 235                 240 


Glu Arg Ser Asp Lys Tyr Ile Glu Glu Leu Glu Ser Gln Val Ala Gln 
                245                 250                 255     


Leu Lys Asn Ser Ser Glu Glu Lys Glu Ala Met Asn Ser Ile Cys Arg 
            260                 265                 270         


Arg Ala Pro Ser Ala Asp Gly Lys Gly Ser Lys Gly Ser Glu Glu Asp 
        275                 280                 285             


Val Ala Ser Lys Asn Gln Gly Asp Ser Ala Arg Lys Gln Pro Gly Ser 
    290                 295                 300                 


Ser Thr Thr Ser Ser Ser His Leu Ala Lys Pro Ser Ser Ser Arg Leu 
305                 310                 315                 320 


Cys Asp Thr Ser Ser Ala Arg Gln Glu Ser Thr Ser Lys Ala Glu Ile 
                325                 330                 335     


Asn Cys Ser Lys Asn Lys Asp Leu Tyr Gln Lys Gln Val Glu Ile Met 
            340                 345                 350         


Leu Asp Val Thr Asp Thr Ser Met Asp Thr Tyr Leu Glu Arg Glu Trp 
        355                 360                 365             


Gly Asn Lys Pro Ser Asp Cys Val Pro Tyr Lys Asp Glu Glu Leu Tyr 
    370                 375                 380                 


Asp Leu Pro Ala Pro Cys Thr Pro Leu Ser Leu Ser Cys Leu Gln Leu 
385                 390                 395                 400 


Ser Thr Pro Glu Asn Arg Glu Ser Ser Val Val Gln Ala Gly Gly Ser 
                405                 410                 415     


Lys Lys His Ser Asn His Leu Arg Lys Leu Val Phe Asp Asp Phe Cys 
            420                 425                 430         


Asp Ser Ser Asn Val Ser Asn Lys Asp Ser Ser Glu Asp Asp Ile Ser 
        435                 440                 445             


Arg Ser Glu Asn Glu Lys Lys Ser Glu Cys Phe Ser Ser Pro Lys Thr 
    450                 455                 460                 


Gly Phe Trp Glu Cys Cys Ser Thr Ser Tyr Ala Gln Asn Leu Asp Phe 
465                 470                 475                 480 


Glu Ser Ser Glu Gly Thr Thr Ile Ala Asn Ser Val Gly Glu Ile Ala 
                485                 490                 495     


Ser Lys Leu Ser Glu Lys Ser Gly Ser Cys Val Ser Lys Arg Leu Asn 
            500                 505                 510         


Ser Ile Arg Ser Phe Glu Met Asn Arg Thr Arg Thr Ser Ser Glu Ala 
        515                 520                 525             


Ser Met Asp Ala Ala Tyr Leu Asp Lys Ile Ser Glu Leu Asp Ser Met 
    530                 535                 540                 


Met Ser Glu Ser Asp Asn Ser Lys Ser Pro Cys Asn Asn Gly Phe Lys 
545                 550                 555                 560 


Ser Leu Asp Leu Asp Gly Leu Ser Lys Ser Ser Gln Gly Ser Glu Phe 
                565                 570                 575     


Leu Glu Glu Pro Asp Lys Leu Glu Glu Lys Thr Lys Leu Asn Leu Ser 
            580                 585                 590         


Lys Gly Ser Leu Thr Asn Asp Gln Leu Glu Asn Gly Asn Glu Trp Lys 
        595                 600                 605             


Pro Thr Ser Phe Phe Leu Leu Ser Pro Ser Asp Gln Glu Met Asn Glu 
    610                 615                 620                 


Asp Phe Ser Leu His Ser Ser Ser Cys Pro Val Thr Asp Glu Ile Lys 
625                 630                 635                 640 


Pro Pro Ser Cys Leu Phe Gln Thr Glu Phe Ser Gln Gly Ile Leu Leu 
                645                 650                 655     


Ser Ser Ser His Arg Leu Phe Glu Asp Gln Arg Phe Gly Ser Ser Leu 
            660                 665                 670         


Phe Lys Met Ser Ser Glu Met His Ser Leu His Asn His Leu Gln Ser 
        675                 680                 685             


Pro Trp Ser Thr Ser Phe Val Pro Glu Lys Arg Asn Lys Asn Val Asn 
    690                 695                 700                 


Gln Ser Thr Lys Arg Lys Ile Gln Ser Ser Leu Ser Asn Ala Ser Pro 
705                 710                 715                 720 


Ser Lys Ala Thr Lys Ser 
                725     


<210>  7
<211>  726
<212>  PRT
<213>  Macaca mulatta

<400>  7

Met Ala Gln Thr Val Gln Asn Val Thr Leu Ser Leu Thr Leu Pro Ile 
1               5                   10                  15      


Thr Cys His Ile Cys Leu Gly Lys Val Arg Gln Pro Val Ile Cys Ile 
            20                  25                  30          


Asn Asn His Val Phe Cys Ser Ile Cys Ile Asp Leu Trp Leu Lys Asn 
        35                  40                  45              


Asn Ser Gln Cys Pro Ala Cys Arg Val Pro Ile Thr Pro Glu Asn Pro 
    50                  55                  60                  


Cys Lys Glu Ile Ile Gly Gly Thr Ser Glu Ser Glu Pro Thr Leu Ser 
65                  70                  75                  80  


His Thr Val Arg Lys His Leu Arg Lys Thr Arg Leu Glu Leu Leu His 
                85                  90                  95      


Lys Glu Tyr Glu Asp Glu Ile Asp Cys Leu Gln Lys Glu Val Glu Glu 
            100                 105                 110         


Leu Lys Ser Lys Asn Leu Ser Leu Glu Ser Gln Ile Lys Thr Ile Leu 
        115                 120                 125             


Asp Pro Leu Thr Leu Val Gln Gly Asn Gln Asn Glu Asp Lys His Leu 
    130                 135                 140                 


Val Thr Asp Asn Pro Thr Lys Ile Asn Pro Glu Thr Val Ala Glu Trp 
145                 150                 155                 160 


Lys Lys Lys Leu Arg Thr Ala Asn Glu Ile Tyr Glu Lys Val Lys Asp 
                165                 170                 175     


Asp Val Asp Lys Leu Lys Glu Ala Asn Lys Lys Leu Lys Leu Glu Asn 
            180                 185                 190         


Gly Gly Leu Val Arg Glu Asn Leu Arg Leu Lys Ala Glu Val Asp Asn 
        195                 200                 205             


Arg Ser Pro Gln Lys Phe Gly Arg Phe Ala Val Ala Ala Leu Gln Ser 
    210                 215                 220                 


Lys Val Glu Gln Tyr Glu Arg Glu Thr Asn Arg Leu Lys Lys Ala Leu 
225                 230                 235                 240 


Glu Arg Ser Asp Lys Tyr Ile Glu Glu Leu Glu Ser Gln Val Ala Gln 
                245                 250                 255     


Leu Lys Asn Ser Ser Glu Glu Lys Glu Ala Met Asn Ser Ile Cys Arg 
            260                 265                 270         


Arg Ala Pro Ser Ala Asp Gly Lys Gly Ser Lys Gly Ser Glu Glu Asp 
        275                 280                 285             


Val Ala Ser Lys Asn Gln Gly Asp Ser Ala Arg Lys Gln Pro Gly Ser 
    290                 295                 300                 


Ser Thr Thr Ser Ser Ser His Leu Ala Lys Pro Ser Ser Ser Arg Leu 
305                 310                 315                 320 


Cys Asp Thr Ser Ser Ala Arg Gln Glu Ser Thr Ser Lys Ala Glu Ile 
                325                 330                 335     


Asn Cys Ser Lys Asn Lys Asp Leu Tyr Gln Lys Gln Val Glu Ile Met 
            340                 345                 350         


Leu Asp Val Thr Asp Thr Ser Met Asp Thr Tyr Leu Glu Arg Glu Trp 
        355                 360                 365             


Gly Asn Lys Pro Ser Asp Cys Val Pro Tyr Lys Asp Glu Glu Leu Tyr 
    370                 375                 380                 


Asp Leu Pro Ala Pro Cys Thr Pro Leu Ser Leu Ser Cys Leu Gln Leu 
385                 390                 395                 400 


Ser Thr Pro Glu Asn Arg Glu Ser Ser Val Val Gln Ala Gly Gly Ser 
                405                 410                 415     


Lys Lys His Ser Asn His Leu Arg Lys Leu Val Phe Asp Asp Phe Cys 
            420                 425                 430         


Asp Ser Ser Asn Val Ser Asn Lys Asp Ser Ser Glu Asp Asp Ile Ser 
        435                 440                 445             


Arg Ser Glu Asn Glu Lys Lys Ser Glu Cys Phe Ser Ser Pro Lys Thr 
    450                 455                 460                 


Gly Phe Trp Glu Cys Cys Ser Thr Ser Tyr Ala Gln Asn Leu Asp Phe 
465                 470                 475                 480 


Glu Ser Ser Glu Gly Thr Thr Ile Ala Asn Ser Val Gly Glu Ile Ala 
                485                 490                 495     


Ser Lys Leu Ser Glu Lys Ser Gly Ser Cys Val Ser Lys Arg Leu Asn 
            500                 505                 510         


Ser Ile Arg Ser Phe Glu Met Asn Arg Thr Arg Thr Ser Ser Glu Ala 
        515                 520                 525             


Ser Met Asp Ala Ala Tyr Leu Asp Lys Ile Ser Glu Leu Asp Ser Met 
    530                 535                 540                 


Met Ser Glu Ser Asp Asn Ser Lys Ser Pro Cys Asn Asn Gly Phe Lys 
545                 550                 555                 560 


Ser Leu Asp Leu Asp Gly Leu Ser Lys Ser Ser Gln Gly Ser Glu Phe 
                565                 570                 575     


Leu Glu Glu Pro Asp Lys Leu Glu Glu Lys Thr Lys Leu Asn Leu Ser 
            580                 585                 590         


Lys Gly Ser Leu Thr Asn Asp Gln Leu Glu Asn Gly Asn Glu Trp Lys 
        595                 600                 605             


Pro Thr Ser Phe Phe Leu Leu Ser Pro Ser Asp Gln Glu Met Asn Glu 
    610                 615                 620                 


Asp Phe Ser Leu His Ser Ser Ser Cys Pro Val Thr Asp Glu Ile Lys 
625                 630                 635                 640 


Pro Pro Ser Cys Leu Phe Gln Thr Glu Phe Ser Gln Gly Ile Leu Leu 
                645                 650                 655     


Ser Ser Ser His Arg Leu Phe Glu Asp Gln Arg Phe Gly Ser Ser Leu 
            660                 665                 670         


Phe Lys Met Ser Ser Glu Met His Ser Leu His Asn His Leu Gln Ser 
        675                 680                 685             


Pro Trp Ser Thr Ser Phe Val Pro Glu Lys Arg Asn Lys Asn Val Asn 
    690                 695                 700                 


Gln Ser Thr Lys Arg Lys Ile Gln Ser Ser Leu Ser Asn Ala Ser Pro 
705                 710                 715                 720 


Ser Lys Ala Thr Lys Ser 
                725     


<210>  8
<211>  724
<212>  PRT
<213>  Callithrix jacchus

<400>  8

Met Ala Gln Thr Val Gln Asn Val Thr Leu Ser Leu Thr Leu Pro Ile 
1               5                   10                  15      


Thr Cys His Ile Cys Leu Gly Lys Val Arg Gln Pro Val Ile Cys Ile 
            20                  25                  30          


Asn Asn His Val Phe Cys Ser Ile Cys Ile Asp Leu Trp Leu Lys Asn 
        35                  40                  45              


Asn Ser Gln Cys Pro Ala Cys Arg Val Pro Ile Thr Pro Glu Asn Pro 
    50                  55                  60                  


Cys Lys Glu Ile Ile Gly Gly Thr Ser Glu Ser Glu Pro Met Leu Ser 
65                  70                  75                  80  


His Thr Val Arg Lys His Leu Arg Lys Thr Arg Phe Glu Leu Leu His 
                85                  90                  95      


Lys Glu Tyr Glu Asp Glu Ile Asp Cys Leu Gln Lys Glu Val Glu Glu 
            100                 105                 110         


Leu Lys Ser Lys Asn Leu Ser Leu Glu Ser Gln Ile Lys Thr Ile Leu 
        115                 120                 125             


Asp Pro Leu Thr Leu Val Gln Gly Asn Gln Asn Glu Asn Lys His Leu 
    130                 135                 140                 


Val Thr Asp Asn Pro Ser Lys Ser Thr Pro Glu Thr Val Ala Glu Trp 
145                 150                 155                 160 


Lys Lys Lys Leu Arg Thr Ala Asn Glu Ile Tyr Glu Lys Val Lys Asp 
                165                 170                 175     


Asp Val Asp Lys Leu Lys Glu Val Asn Lys Lys Leu Lys Leu Glu Asn 
            180                 185                 190         


Gly Gly Leu Val Arg Glu Asn Leu Arg Leu Lys Ala Glu Val Asp Asn 
        195                 200                 205             


Arg Ser Pro Gln Lys Phe Gly Arg Phe Ala Val Ala Ala Leu Gln Ser 
    210                 215                 220                 


Lys Val Glu Gln Tyr Glu Arg Glu Thr Asn Arg Leu Lys Lys Ala Leu 
225                 230                 235                 240 


Glu Arg Ser Asp Lys Tyr Ile Glu Glu Leu Glu Ser Gln Val Ala Arg 
                245                 250                 255     


Leu Lys Asn Ser Ser Glu Glu Lys Glu Ala Met Asn Ser Ile Cys Gln 
            260                 265                 270         


Arg Ala Leu Ser Ala Asp Gly Lys Gly Ser Lys Gly Ser Glu Glu Asp 
        275                 280                 285             


Val Ala Ser Lys Asn Gln Gly Asp Ser Ala Arg Lys Gln Pro Ser Ser 
    290                 295                 300                 


Ser Thr Ser Ser Ser His Leu Pro Lys Pro Ser Ser Ser Arg Leu Cys 
305                 310                 315                 320 


Asp Ser Ser Ala Arg Gln Glu Asn Thr Ser Lys Ala Glu Leu Asn Cys 
                325                 330                 335     


Ser Lys Asn Lys Asp Leu Tyr Gln Lys Gln Val Glu Ile Met Leu Asp 
            340                 345                 350         


Val Thr Asp Thr Ser Met Asp Thr Tyr Leu Glu Arg Glu Trp Gly Asn 
        355                 360                 365             


Lys Pro Ser Asp Cys Val Pro Tyr Lys Gly Glu Glu Leu Tyr Asp Leu 
    370                 375                 380                 


Pro Ala Pro Cys Thr Pro Leu Ser Leu Ser Cys Leu His Leu Ser Thr 
385                 390                 395                 400 


Pro Glu Ser Arg Glu Ser Ser Val Val Gln Val Gly Gly Ser Lys Lys 
                405                 410                 415     


His Ser Asn His Leu Arg Lys Leu Val Phe Asp Asp Phe Cys Asp Ser 
            420                 425                 430         


Ser Ser Val Ser Asn Lys Asp Ser Ser Glu Asp Asp Ile Ser Arg Ser 
        435                 440                 445             


Glu Asn Glu Lys Lys Ser Glu Cys Phe Thr Ser Pro Lys Thr Gly Phe 
    450                 455                 460                 


Trp Asp Cys Cys Ser Thr Ser Phe Ala Gln Ser Leu Asp Phe Glu Ser 
465                 470                 475                 480 


Ser Glu Gly Asn Thr Ile Ala Asn Ser Val Gly Glu Ile Ser Ser Lys 
                485                 490                 495     


Leu Ser Glu Lys Ser Gly Ser Cys Ile Ser Lys Arg Leu Asn Ser Ile 
            500                 505                 510         


Arg Ser Phe Glu Met Asn Arg Thr Arg Thr Ser Ser Glu Ala Ser Met 
        515                 520                 525             


Asp Ala Ala Tyr Leu Asp Lys Ile Ser Glu Leu Asp Ser Met Met Ser 
    530                 535                 540                 


Glu Ser Asp Asn Ser Lys Ser Pro Cys Asn Asn Gly Phe Lys Ser Leu 
545                 550                 555                 560 


Asp Leu Asp Gly Leu Ser Lys Ser Ser Gln Gly Ser Glu Phe Leu Glu 
                565                 570                 575     


Glu Pro Asp Lys Leu Glu Glu Lys Thr Lys Leu Asn Leu Ser Lys Gly 
            580                 585                 590         


Ser Leu Thr Asn Asp Gln Leu Glu Asn Gly Asn Glu Trp Lys Pro Thr 
        595                 600                 605             


Ser Phe Phe Leu Leu Ser Pro Ser Asp Gln Glu Met Asn Asp Asp Phe 
    610                 615                 620                 


Ser Leu His Ser Gly Ser Ser Pro Gly Thr Asn Glu Leu Lys Pro Pro 
625                 630                 635                 640 


Ser Cys Leu Phe Gln Thr Glu Phe Ser Gln Gly Ile Leu Leu Ser Ser 
                645                 650                 655     


Ser His Arg Leu Phe Glu Asp Gln Arg Phe Gly Ser Ser Leu Phe Lys 
            660                 665                 670         


Met Ser Ser Glu Met His Ser Leu His Asn His Leu Gln Ser Pro Trp 
        675                 680                 685             


Ser Thr Ser Phe Val Pro Glu Lys Arg Asn Lys Asn Val Asn Gln Ser 
    690                 695                 700                 


Thr Lys Arg Lys Ile Gln Ser Ser Leu Ser Asn Ala Ser Pro Ser Lys 
705                 710                 715                 720 


Ala Thr Lys Ser 
                


<210>  9
<211>  717
<212>  PRT
<213>  Equus caballus

<400>  9

Met Ala Gln Thr Val Gln Asn Val Thr Leu Ser Leu Thr Leu Pro Ile 
1               5                   10                  15      


Thr Cys His Ile Cys Leu Gly Lys Val Arg Gln Pro Val Ile Cys Ile 
            20                  25                  30          


Asn Asn His Val Phe Cys Ser Ile Cys Ile Asp Leu Trp Leu Lys Asn 
        35                  40                  45              


Asn Ser Gln Cys Pro Ala Cys Arg Val Pro Ile Thr Pro Glu Asn Pro 
    50                  55                  60                  


Cys Lys Glu Ile Ile Gly Gly Thr Ser Glu Ser Glu Pro Met Leu Ser 
65                  70                  75                  80  


His Thr Val Arg Lys His Leu Arg Lys Thr Arg Leu Glu Leu Leu His 
                85                  90                  95      


Lys Glu Tyr Glu Asp Glu Ile Asp Cys Leu Gln Lys Glu Val Glu Glu 
            100                 105                 110         


Leu Lys Ser Lys Asn Leu Ser Leu Glu Ser Gln Ile Lys Thr Ile Leu 
        115                 120                 125             


Asp Pro Leu Thr Leu Met Gln Gly Asn Gln Asn Glu Asp Lys His Pro 
    130                 135                 140                 


Val Ala Asp Asn Pro Ser Lys Ile Asp Pro Glu Thr Val Ala Glu Trp 
145                 150                 155                 160 


Lys Lys Lys Leu Arg Thr Ala Asn Glu Ile Tyr Glu Lys Val Lys Asp 
                165                 170                 175     


Asp Val Asp Lys Leu Lys Glu Ala Asn Lys Asn Leu Lys Leu Glu Asn 
            180                 185                 190         


Gly Gly Leu Val Arg Glu Asn Leu Arg Leu Lys Ala Glu Val Asp Asn 
        195                 200                 205             


Arg Ser Pro Gln Lys Phe Gly Arg Phe Thr Val Ala Ala Leu Gln Ser 
    210                 215                 220                 


Lys Val Glu Gln Tyr Glu Arg Glu Thr Asn Arg Leu Lys Lys Ala Leu 
225                 230                 235                 240 


Glu Arg Ser Asp Lys Tyr Ile Glu Glu Leu Glu Ser Gln Ile Ala Gln 
                245                 250                 255     


Leu Lys Asn Ser Ser Glu Glu Lys Glu Ala Met Asn Ser Ile Cys Gln 
            260                 265                 270         


Arg Thr Leu Ser Thr Asp Gly Lys Gly Ser Lys Cys Ser Glu Glu Asp 
        275                 280                 285             


Met Ala Ser Lys Asn Gln Gly Asp Gly Ala Arg Lys Gln Leu Gly Ser 
    290                 295                 300                 


Ser Thr Ser Ser Ser His Leu Ala Lys Pro Ser Ser Ser Ser Ala Arg 
305                 310                 315                 320 


Gln Glu Gly Ile Ser Lys Thr Glu Pro Asn Cys Ser Lys Asn Lys Asp 
                325                 330                 335     


Leu Tyr Gln Lys Gln Val Glu Ile Met Leu Asp Val Thr Asp Thr Ser 
            340                 345                 350         


Met Asp Thr Tyr Leu Glu Arg Glu Trp Gly Asn Lys Pro Ser Asp Cys 
        355                 360                 365             


Val Pro Tyr Lys Asp Glu Glu Leu Tyr Asp Leu Pro Ala Pro Cys Thr 
    370                 375                 380                 


Pro Leu Ser Leu Ser Cys Leu Gln Leu Ser Thr Pro Glu Asn Arg Glu 
385                 390                 395                 400 


Ser Ser Val Val Lys Ala Gly Gly Ser Lys Lys His Ser Asn His Leu 
                405                 410                 415     


Arg Lys Leu Val Phe Asp Asp Phe Cys Asp Ser Ser Ser Val Cys Asn 
            420                 425                 430         


Lys Asp Ser Ser Glu Asp Asp Arg Ser Glu Asn Glu Lys Lys Ser Asp 
        435                 440                 445             


Cys Phe Thr Ser Pro Lys Thr Gly Phe Trp Asp Cys Cys Ser Thr Ser 
    450                 455                 460                 


Tyr Ala Gln Ser Leu Asp Phe Glu Ser Ser Glu Gly Asn Thr Ile Ala 
465                 470                 475                 480 


Asn Ser Val Gly Glu Ile Ser Ser Lys Leu Ser Glu Lys Ser Gly Ser 
                485                 490                 495     


Cys Leu Ser Lys Arg Leu Asn Ser Ile Arg Ser Phe Glu Met Asn Arg 
            500                 505                 510         


Thr Arg Thr Ser Ser Glu Ala Ser Met Asp Ala Ala Tyr Leu Asp Lys 
        515                 520                 525             


Ile Ser Glu Leu Asp Ser Met Met Ser Glu Ser Asp Asn Ser Lys Ser 
    530                 535                 540                 


Pro Cys Asn Asn Gly Phe Lys Ser Val Asp Leu Asp Gly Leu Ser Lys 
545                 550                 555                 560 


Ser Ser Gln Gly Ser Glu Phe Leu Glu Glu Ser Asp Lys Leu Glu Glu 
                565                 570                 575     


Arg Thr Lys Pro Asn Leu Ser Lys Gly Ser Leu Thr Thr Asp Gln Leu 
            580                 585                 590         


Glu Asn Gly Asn Glu Trp Lys Pro Thr Ser Phe Phe Leu Leu Ser Pro 
        595                 600                 605             


Ser Asp Gln Glu Met Asn Glu Asp Phe Ser Leu His Pro Ser Ser Asn 
    610                 615                 620                 


Pro Gly Thr Asn Glu Ile Lys Pro Pro Ser Cys Leu Phe Gln Thr Glu 
625                 630                 635                 640 


Phe Ser Gln Gly Val Leu Leu Ser Ser Ser His Arg Leu Phe Glu Asp 
                645                 650                 655     


Gln Arg Phe Gly Ser Ser Leu Phe Lys Met Ser Ser Glu Met His Gly 
            660                 665                 670         


Leu His Asn Gln Leu Gln Ser Pro Trp Ser Thr Ser Phe Val Pro Glu 
        675                 680                 685             


Lys Arg Asn Lys Asn Val Asn Gln Ser Thr Lys Arg Lys Ile Gln Ser 
    690                 695                 700                 


Ser Leu Ser Asn Ala Ser Pro Ser Lys Ala Thr Lys Ser 
705                 710                 715         


<210>  10
<211>  726
<212>  PRT
<213>  Spermophilus tridecemlineatus

<400>  10

Met Ala Gln Thr Val Gln Asn Val Thr Leu Ser Leu Thr Leu Pro Ile 
1               5                   10                  15      


Thr Cys His Ile Cys Leu Gly Lys Val Arg Gln Pro Val Ile Cys Ile 
            20                  25                  30          


Asn Asn His Val Phe Cys Ser Ile Cys Ile Asp Leu Trp Leu Lys Asn 
        35                  40                  45              


Asn Ser Gln Cys Pro Ala Cys Arg Val Pro Ile Thr Pro Glu Asn Pro 
    50                  55                  60                  


Cys Lys Glu Ile Ile Gly Gly Thr Ser Glu Ser Glu Pro Met Leu Thr 
65                  70                  75                  80  


His Thr Val Arg Lys His Leu Arg Lys Thr Arg Leu Glu Leu Leu His 
                85                  90                  95      


Lys Glu Tyr Glu Asp Glu Ile Asp Cys Leu Gln Lys Glu Val Glu Glu 
            100                 105                 110         


Leu Lys Ser Lys Asn Leu Ser Leu Glu Ser Gln Ile Lys Thr Ile Leu 
        115                 120                 125             


Asp Pro Leu Thr Leu Met Gln Gly Ser Gln Asn Glu Asp Lys His Pro 
    130                 135                 140                 


Val Ala Asp Asn Pro Ser Lys Ile Asp Ser Glu Thr Val Ala Glu Trp 
145                 150                 155                 160 


Lys Lys Lys Leu Arg Thr Ala Asn Glu Ile Tyr Glu Lys Val Lys Asp 
                165                 170                 175     


Asp Val Asp Lys Leu Lys Glu Ala Asn Lys Lys Leu Lys Leu Glu Asn 
            180                 185                 190         


Gly Gly Leu Val Arg Glu Asn Leu Arg Leu Lys Ala Glu Val Asp Asn 
        195                 200                 205             


Arg Ser Pro Gln Lys Phe Gly Arg Phe Thr Val Ala Ala Leu Gln Ser 
    210                 215                 220                 


Lys Val Glu Gln Tyr Glu Arg Glu Thr Asn Arg Leu Lys Lys Ala Leu 
225                 230                 235                 240 


Glu Arg Ser Asp Lys Tyr Ile Glu Glu Leu Glu Ser Gln Val Ala Gln 
                245                 250                 255     


Leu Lys Asn Ser Ser Glu Glu Lys Glu Thr Ile Asp Ser Ile Cys Gln 
            260                 265                 270         


Arg Ala Leu Ser Ala Asp Gly Asn Gly Ser Lys Ser Ser Glu Glu Asp 
        275                 280                 285             


Val Ala Ser Lys Asn Gln Gly Asp Ser Ala Arg Lys Gln Pro Gly Ser 
    290                 295                 300                 


Ser Ala Ser Ile Thr Val His Leu Ala Lys Pro Ser Ser Gly Arg Ile 
305                 310                 315                 320 


Ser Asp Thr Ser Ser Ala Arg Gln Glu Asn Thr Ser Lys Thr Glu Ser 
                325                 330                 335     


Asn Cys Pro Lys Asn Lys Asp Met Tyr Gln Lys Gln Val Glu Ile Met 
            340                 345                 350         


Leu Asp Val Thr Asp Thr Ser Met Asp Thr Tyr Leu Glu Gly Glu Trp 
        355                 360                 365             


Ser Asn Lys Pro Asn Asp Cys Val Pro Phe Lys Asp Glu Glu Leu Tyr 
    370                 375                 380                 


Asp Leu Pro Ala Pro Cys Thr Pro Leu Ser Leu Ser Cys Leu Gln Leu 
385                 390                 395                 400 


Asn Thr Pro Glu Asn Arg Glu Ser Ser Val Val Lys Ala Gly Ser Ser 
                405                 410                 415     


Lys Lys His Ser Asn His Leu Arg Lys Leu Val Phe Asp Asp Phe Cys 
            420                 425                 430         


Asp Ser Gln Asn Val Cys Asn Lys Asp Ser Ser Glu Asp Asp Thr Ser 
        435                 440                 445             


Arg Asn Glu Asn Glu Lys Lys Ser Glu Cys Phe Thr Ser Pro Lys Thr 
    450                 455                 460                 


Gly Phe Trp Asp Cys Cys Ser Thr Ser Tyr Ala Gln Ser Leu Asp Phe 
465                 470                 475                 480 


Glu Asn Ser Glu Glu Asn Thr Ile Ala Asn Ser Val Gly Glu Ile Ser 
                485                 490                 495     


Leu Lys Leu Ser Glu Lys Ser Gly Ser Cys Leu Ser Lys Arg Leu Asn 
            500                 505                 510         


Cys Ile Arg Thr Phe Glu Met Asn Arg Thr Arg Thr Ser Ser Glu Ala 
        515                 520                 525             


Ser Met Asp Ala Ala Tyr Leu Asp Lys Ile Ser Glu Leu Asp Ser Met 
    530                 535                 540                 


Met Ser Glu Ser Asp Asn Ser Lys Ser Pro Cys Asn Asn Gly Phe Lys 
545                 550                 555                 560 


Ser Val Asp Val Asp Gly Leu Ser Lys Ser Ser Gln Gly Ser Glu Phe 
                565                 570                 575     


Leu Glu Glu Ser Glu Lys Leu Glu Glu Arg Thr Lys Leu Asn Leu Ser 
            580                 585                 590         


Lys Ser Ser Leu Thr Thr Asp Gln Leu Glu Asn Gly Asn Glu Trp Lys 
        595                 600                 605             


Pro Thr Ser Phe Phe Leu Leu Ser Pro Ser Asp Gln Glu Met Asn Glu 
    610                 615                 620                 


Asp Phe Ser Leu His Ser Thr Ser Asn Pro Gly Thr Asn Asp Ile Lys 
625                 630                 635                 640 


Pro Pro Ser Cys Leu Phe Gln Thr Glu Phe Ser Gln Gly Val Leu Leu 
                645                 650                 655     


Ser Ser Ser His Arg Leu Phe Glu Asp Gln Arg Phe Gly Ser Ser Leu 
            660                 665                 670         


Phe Lys Thr Ser Ser Glu Met His Ser Leu His Asn His Leu Gln Ser 
        675                 680                 685             


Pro Trp Ser Thr Ser Phe Val Pro Glu Lys Arg Asn Lys Asn Val Asn 
    690                 695                 700                 


Gln Ser Thr Lys Arg Lys Ile Gln Ser Ser Leu Ser Asn Ala Ser Pro 
705                 710                 715                 720 


Ser Lys Ala Thr Lys Ser 
                725     


<210>  11
<211>  717
<212>  PRT
<213>  Ailuropoda melanoleuca

<400>  11

Met Ala Gln Thr Val Gln Asn Val Thr Leu Ser Leu Thr Leu Pro Ile 
1               5                   10                  15      


Thr Cys His Ile Cys Leu Gly Lys Val Arg Gln Pro Val Ile Cys Ile 
            20                  25                  30          


Asn Asn His Val Phe Cys Ser Ile Cys Ile Asp Leu Trp Leu Lys Asn 
        35                  40                  45              


Asn Ser Gln Cys Pro Ala Cys Arg Val Pro Ile Thr Pro Glu Asn Pro 
    50                  55                  60                  


Cys Lys Glu Ile Ile Gly Gly Thr Ser Glu Ser Glu Pro Met Leu Ser 
65                  70                  75                  80  


His Thr Val Arg Lys His Leu Arg Lys Thr Arg Leu Glu Leu Leu His 
                85                  90                  95      


Lys Glu Tyr Glu Asp Glu Ile Asp Cys Leu Gln Lys Glu Val Glu Asp 
            100                 105                 110         


Leu Lys Ser Lys Asn Leu Ser Leu Glu Ser Gln Ile Lys Thr Ile Leu 
        115                 120                 125             


Asp Pro Leu Thr Leu Met Gln Gly Asn Gln Asn Glu Glu Lys His Pro 
    130                 135                 140                 


Val Ala Asp Asn Pro Ser Lys Ile Asp Pro Glu Thr Val Ala Glu Trp 
145                 150                 155                 160 


Lys Lys Lys Leu Arg Thr Ala Asn Glu Ile Tyr Glu Lys Val Lys Asp 
                165                 170                 175     


Asp Val Asp Lys Leu Lys Glu Ala Asn Lys Lys Leu Lys Leu Glu Asn 
            180                 185                 190         


Gly Gly Leu Val Arg Glu Asn Leu Arg Leu Lys Ala Glu Val Asp Asn 
        195                 200                 205             


Arg Ser Pro Gln Lys Phe Gly Arg Phe Thr Val Ala Ala Leu Gln Ser 
    210                 215                 220                 


Lys Val Glu Gln His Glu Arg Glu Thr Asn Arg Leu Lys Lys Ala Leu 
225                 230                 235                 240 


Glu Arg Ser Asp Lys Tyr Ile Glu Glu Leu Glu Ser Gln Ile Ala Gln 
                245                 250                 255     


Leu Lys Asn Ser Ser Glu Glu Lys Glu Ala Met Asn Ser Val Cys Gln 
            260                 265                 270         


Arg Ala Leu Ser Thr Asp Gly Lys Gly Ser Ile Gly Asn Glu Glu Asp 
        275                 280                 285             


Met Ala Ser Lys Asn Gln Gly Asp Gly Ala Arg Lys Gln Leu Gly Ser 
    290                 295                 300                 


Ser Thr Ser Ser Ser His Leu Ala Lys Pro Ser Ser Ser Ser Ala Arg 
305                 310                 315                 320 


Gln Glu Ser Thr Ser Lys Thr Glu Pro Asn Cys Ser Lys Asn Lys Asp 
                325                 330                 335     


Leu Tyr Gln Lys Gln Val Glu Ile Met Leu Asp Val Thr Asp Thr Ser 
            340                 345                 350         


Met Asp Thr Tyr Leu Glu Arg Glu Trp Gly Asn Lys Arg Ser Asp Cys 
        355                 360                 365             


Ile Pro Tyr Lys Asp Glu Glu Leu Tyr Asp Leu Pro Ala Pro Cys Thr 
    370                 375                 380                 


Pro Leu Ser Leu Ser Cys Leu Gln Leu Ser Thr Pro Glu Asn Arg Glu 
385                 390                 395                 400 


Ser Pro Val Val Lys Ala Val Gly Ser Lys Lys His Ser Asn His Leu 
                405                 410                 415     


Arg Lys Leu Val Phe Asp Asp Phe Cys Asp Ser Pro Asn Val Cys Asn 
            420                 425                 430         


Lys Asp Ser Ser Glu Asp Asp Arg Ser Glu Asn Glu Lys Lys Ser Glu 
        435                 440                 445             


Cys Phe Thr Ser Ser Lys Thr Gly Phe Trp Asp Cys Cys Ser Thr Ser 
    450                 455                 460                 


Tyr Ala Gln Asn Leu Asp Phe Glu Ser Pro Glu Gly Asn Thr Ile Ala 
465                 470                 475                 480 


Asn Ser Val Gly Glu Ile Thr Leu Lys Leu Ser Glu Lys Ser Gly Ser 
                485                 490                 495     


Cys Leu Ser Lys Arg Leu Asn Ser Ile Arg Ser Phe Glu Met Asn Arg 
            500                 505                 510         


Thr Arg Thr Ser Ser Glu Ala Ser Met Asp Ala Ala Tyr Leu Asp Lys 
        515                 520                 525             


Ile Ser Glu Leu Asp Ser Met Met Ser Glu Ser Asp Asn Ser Lys Ser 
    530                 535                 540                 


Pro Cys Asn Asn Gly Phe Lys Ser Val Asp Leu Asp Gly Leu Ser Lys 
545                 550                 555                 560 


Ser Ser Gln Gly Ser Glu Phe Leu Glu Glu Pro Glu Lys Leu Glu Glu 
                565                 570                 575     


Arg Thr Lys Ala Asn Leu Ser Lys Gly Ser Leu Thr Thr Asp Gln Leu 
            580                 585                 590         


Glu Asn Gly Asn Asp Trp Lys Pro Thr Ser Phe Phe Leu Leu Ser Pro 
        595                 600                 605             


Ser Asp Gln Glu Met Asn Glu Asp Phe Ser Leu His Thr Ser Ser Asn 
    610                 615                 620                 


Pro Gly Thr Asn Glu Ile Lys Pro Pro Ser Cys Leu Phe Gln Thr Glu 
625                 630                 635                 640 


Phe Ser Gln Gly Val Leu Leu Ser Ser Ser His Arg Leu Phe Glu Asp 
                645                 650                 655     


Gln Arg Phe Gly Ser Ser Leu Phe Lys Met Thr Ser Glu Met His Gly 
            660                 665                 670         


Leu His Asn His Leu Gln Ser Pro Trp Ser Thr Ser Phe Val Pro Glu 
        675                 680                 685             


Lys Arg Asn Lys Asn Met Asn Gln Ser Thr Lys Arg Lys Ile Gln Ser 
    690                 695                 700                 


Ser Leu Ser Asn Ala Ser Pro Ser Lys Ala Thr Lys Ser 
705                 710                 715         


<210>  12
<211>  717
<212>  PRT
<213>  Canis familiaris

<400>  12

Met Ala Gln Thr Val Gln Asn Val Thr Leu Ser Leu Thr Leu Pro Ile 
1               5                   10                  15      


Thr Cys His Ile Cys Leu Gly Lys Val Arg Gln Pro Val Ile Cys Ile 
            20                  25                  30          


Asn Asn His Val Phe Cys Ser Ile Cys Ile Asp Leu Trp Leu Lys Asn 
        35                  40                  45              


Asn Ser Gln Cys Pro Ala Cys Arg Val Pro Ile Thr Pro Glu Asn Pro 
    50                  55                  60                  


Cys Lys Glu Ile Ile Gly Gly Thr Ser Glu Ser Glu Pro Met Leu Ser 
65                  70                  75                  80  


His Thr Val Arg Lys His Leu Arg Lys Thr Arg Leu Glu Leu Leu His 
                85                  90                  95      


Lys Glu Tyr Glu Asp Glu Ile Asp Cys Leu Gln Lys Glu Val Glu Asp 
            100                 105                 110         


Leu Lys Ser Lys Asn Leu Ser Leu Glu Ser Gln Ile Lys Thr Ile Leu 
        115                 120                 125             


Asp Pro Leu Ala Val Met Gln Gly Asn Gln Asn Glu Asp Lys His Pro 
    130                 135                 140                 


Val Ala Asp Asn Pro Ser Lys Ile Gly Pro Glu Thr Glu Ala Glu Trp 
145                 150                 155                 160 


Lys Lys Lys Leu Arg Thr Ala Asn Glu Ile Tyr Glu Lys Val Lys Asp 
                165                 170                 175     


Asp Val Asp Lys Leu Lys Glu Ala Asn Lys Lys Leu Lys Leu Glu Asn 
            180                 185                 190         


Gly Gly Leu Val Arg Glu Asn Leu Arg Leu Lys Ala Glu Val Asp Asn 
        195                 200                 205             


Arg Ser Pro Gln Lys Phe Gly Arg Phe Thr Val Ala Ala Leu Gln Ser 
    210                 215                 220                 


Lys Val Glu Gln His Glu Arg Glu Thr Asn Arg Leu Lys Lys Ala Leu 
225                 230                 235                 240 


Glu Arg Ser Asp Lys Tyr Ile Glu Glu Leu Glu Ser Gln Ile Ala Gln 
                245                 250                 255     


Leu Lys Asn Ser Ser Glu Glu Lys Glu Ala Met Asn Ser Ile Cys Gln 
            260                 265                 270         


Arg Ala Leu Ser Thr Asp Gly Lys Gly Ser Ile Gly Asn Glu Glu Asp 
        275                 280                 285             


Met Ala Ser Lys Ser Gln Gly Asp Gly Ala Arg Lys Gln Val Gly Ser 
    290                 295                 300                 


Ser Thr Ser Ser Ser His Leu Ala Lys Pro Ser Ser Ser Ser Ala Arg 
305                 310                 315                 320 


Gln Glu Cys Thr Ser Lys Thr Glu Pro Asn Cys Ser Lys Asn Lys Asp 
                325                 330                 335     


Leu Tyr Gln Lys Gln Val Glu Ile Met Leu Asp Val Thr Asp Thr Ser 
            340                 345                 350         


Met Asp Thr Tyr Leu Glu Arg Glu Trp Gly Asn Lys Pro Ser Asp Cys 
        355                 360                 365             


Ile Pro Tyr Lys Asp Glu Glu Leu Tyr Asp Leu Pro Ala Pro Cys Thr 
    370                 375                 380                 


Pro Leu Ser Leu Ser Cys Leu Gln Leu Ser Thr Pro Glu Asn Arg Glu 
385                 390                 395                 400 


Ser Ser Val Val Lys Ala Val Gly Ser Lys Lys His Ser Asn His Leu 
                405                 410                 415     


Arg Lys Leu Val Phe Asp Asp Phe Cys Asp Ser Pro Asn Val Cys Asn 
            420                 425                 430         


Lys Asp Ser Ser Glu Asp Asp Arg Ser Glu Asn Glu Lys Lys Ser Glu 
        435                 440                 445             


Cys Phe Thr Ser Ser Lys Thr Gly Phe Trp Asp Cys Cys Ser Thr Ser 
    450                 455                 460                 


Tyr Ala Gln Asn Leu Asp Phe Glu Ser Ser Glu Gly Asn Thr Ile Ala 
465                 470                 475                 480 


Asn Ser Val Gly Glu Ile Ser Leu Lys Leu Ser Glu Lys Ser Gly Ser 
                485                 490                 495     


Cys Leu Ser Lys Arg Leu Asn Ser Ile Arg Ser Phe Glu Met Asn Arg 
            500                 505                 510         


Thr Arg Thr Ser Ser Glu Ala Ser Met Asp Ala Ala Tyr Leu Asp Lys 
        515                 520                 525             


Ile Ser Glu Leu Asp Ser Met Met Ser Glu Ser Asp Asn Ser Lys Ser 
    530                 535                 540                 


Pro Cys Asn Asn Gly Phe Lys Ser Val Asp Leu Asp Gly Leu Ser Lys 
545                 550                 555                 560 


Ser Ser Gln Gly Ser Glu Phe Leu Glu Glu Pro Asp Lys Leu Glu Glu 
                565                 570                 575     


Arg Thr Lys Pro Asn Leu Ser Lys Gly Ser Leu Thr Thr Asp Gln Leu 
            580                 585                 590         


Glu Asn Gly Asn Glu Trp Lys Pro Thr Ser Phe Phe Leu Leu Ser Pro 
        595                 600                 605             


Ser Asp Gln Glu Met Asn Glu Asp Phe Ser Leu His Thr Ser Ser Asn 
    610                 615                 620                 


Pro Gly Thr Asn Glu Ile Lys Pro Pro Ser Cys Leu Phe Gln Thr Glu 
625                 630                 635                 640 


Phe Ser Gln Gly Val Leu Leu Ser Ser Ser His Arg Leu Phe Glu Asp 
                645                 650                 655     


Gln Arg Phe Gly Ser Ser Leu Phe Lys Met Thr Ser Glu Met His Gly 
            660                 665                 670         


Leu His Asn His Leu Gln Ser Pro Trp Ser Ala Ser Phe Val Pro Glu 
        675                 680                 685             


Lys Arg Asn Lys Asn Met Asn Gln Ser Ala Lys Arg Lys Ile Gln Ser 
    690                 695                 700                 


Ser Leu Ser Asn Ala Ser Pro Ser Lys Ala Thr Lys Ser 
705                 710                 715         


<210>  13
<211>  725
<212>  PRT
<213>  Oryctolagus cuniculus

<400>  13

Met Ala Gln Thr Val Gln Asn Val Thr Leu Ser Leu Thr Leu Pro Ile 
1               5                   10                  15      


Thr Cys His Ile Cys Leu Gly Lys Val Arg Gln Pro Val Ile Cys Ile 
            20                  25                  30          


Asn Asn His Val Phe Cys Ser Val Cys Ile Asp Leu Trp Leu Lys Asn 
        35                  40                  45              


Asn Ser Gln Cys Pro Ala Cys Arg Val Pro Ile Thr Pro Glu Asn Pro 
    50                  55                  60                  


Cys Lys Glu Ile Ile Gly Gly Thr Ser Glu Ser Glu Pro Met Leu Ser 
65                  70                  75                  80  


His Thr Val Arg Lys His Leu Arg Lys Thr Arg Leu Glu Leu Leu His 
                85                  90                  95      


Lys Glu Tyr Glu Asp Glu Ile Asp Cys Leu Gln Lys Glu Val Glu Glu 
            100                 105                 110         


Leu Lys Ser Lys Asn Leu Ser Leu Glu Ser Gln Ile Lys Thr Ile Leu 
        115                 120                 125             


Asp Pro Leu Thr Leu Met Gln Gly Asn Gln Asn Glu Asp Lys His Pro 
    130                 135                 140                 


Val Ala Asp Asn Pro Asn Thr Val Asp Pro Glu Thr Ile Ala Glu Trp 
145                 150                 155                 160 


Lys Lys Lys Leu Arg Thr Ala Asn Glu Ile Tyr Glu Lys Val Lys Asp 
                165                 170                 175     


Asp Val Asp Lys Leu Lys Glu Ala Asn Lys Lys Leu Lys Leu Glu Asn 
            180                 185                 190         


Gly Gly Leu Val Arg Glu Asn Leu Arg Leu Lys Ala Glu Val Asp Asn 
        195                 200                 205             


Arg Ser Pro Gln Lys Phe Gly Arg Phe Thr Val Ala Ala Leu Gln Ser 
    210                 215                 220                 


Lys Val Glu Gln Tyr Glu Arg Glu Thr Asn Arg Leu Lys Lys Ala Leu 
225                 230                 235                 240 


Glu Arg Ser Asp Lys Tyr Ile Glu Glu Leu Glu Ser Gln Val Thr Gln 
                245                 250                 255     


Leu Lys His Ser Ser Glu Glu Lys Glu Ala Met Asp Ser Ile Cys Gln 
            260                 265                 270         


Arg Val Leu Ser Ala Asp Gly Lys Arg Ile Lys Asp Ser Glu Glu Asp 
        275                 280                 285             


Met Val Ser Lys Asn Gln Cys Asp Asn Ala Arg Thr Gln Ser Gly Ser 
    290                 295                 300                 


Ser Thr Ser Ser Ser His Leu Thr Lys Pro Ser Ser Ser Arg Leu Ser 
305                 310                 315                 320 


Asp Thr Ser Ser Ala Arg Gln Glu Ser Thr Ser Lys Thr Glu Pro Asn 
                325                 330                 335     


Ser Ser Lys Asn Lys Asp Leu Tyr Gln Lys Arg Val Glu Ile Met Leu 
            340                 345                 350         


Asp Val Thr Asp Ala Asn Met Asp Ala Tyr Leu Glu Arg Glu Trp Gly 
        355                 360                 365             


Asn Lys Pro Ser Asp Cys Val Pro Tyr Lys Asp Glu Glu Leu Tyr Asp 
    370                 375                 380                 


Leu Pro Ala Pro Cys Thr Pro Leu Ser Leu Ser Cys Leu Gln Leu Asn 
385                 390                 395                 400 


Thr Pro Glu Asn Arg Glu Ser Ser Val Val Lys Ala Gly Ser Ser Arg 
                405                 410                 415     


Lys His Ser Asn His Leu Arg Lys Leu Val Phe Asp Asp Phe Cys Asp 
            420                 425                 430         


Ser Thr Asn Val Cys Asn Lys Asp Ser Ser Glu Asp Asp Ile Ser Arg 
        435                 440                 445             


Ser Glu Asn Glu Lys Lys Ser Glu Cys Phe Thr Ser Pro Lys Thr Gly 
    450                 455                 460                 


Phe Trp Asp Cys Cys Ser Thr Ser Tyr Ala Gln Ser Leu Asp Phe Glu 
465                 470                 475                 480 


Ser Ser Glu Gly Asn Asn Met Ala Asn Ser Val Gly Glu Ile Ser Ser 
                485                 490                 495     


Lys Leu Ser Glu Lys Ser Gly Ser Cys Leu Ser Lys Lys Leu Asn Ser 
            500                 505                 510         


Ile Arg Ser Phe Glu Ile Asn Arg Thr Arg Thr Ser Ser Glu Ala Ser 
        515                 520                 525             


Met Asp Ala Ala Tyr Leu Asp Lys Ile Ser Glu Leu Asp Ser Met Met 
    530                 535                 540                 


Ser Glu Ser Asp Asn Ser Lys Ser Pro Cys Asn Asn Gly Phe Lys Ser 
545                 550                 555                 560 


Val Asp Leu Asp Gly Leu Ser Lys Ser Ser Gln Gly Ser Glu Phe Leu 
                565                 570                 575     


Glu Glu Pro Glu Lys Leu Glu Glu Arg Thr Lys Leu Ser Leu Ser Lys 
            580                 585                 590         


Gly Ser Leu Thr Thr Asp Gln Leu Ala Asn Gly Asn Glu Trp Lys Pro 
        595                 600                 605             


Ala Ser Phe Phe Leu Leu Ser Pro Ser Asp Gln Glu Met Asn Glu Asp 
    610                 615                 620                 


Phe Ser Leu His Pro Thr Ser Asn Pro Gly Thr Asn Glu Ile Lys Pro 
625                 630                 635                 640 


Pro Ser Cys Leu Phe Gln Thr Glu Phe Ser Gln Asn Val Leu Leu Ser 
                645                 650                 655     


Ser Ser His Arg Leu Phe Glu Asp Gln Arg Phe Gly Ser Ser Leu Phe 
            660                 665                 670         


Lys Met Ser Ser Glu Met His Gly Leu Gly Asn His Leu Gln Ser Pro 
        675                 680                 685             


Trp Ser Thr Ser Phe Val Pro Glu Lys Arg Asn Lys Asn Met Asn Gln 
    690                 695                 700                 


Ser Thr Lys Arg Lys Ile Gln Ser Ser Leu Ser Asn Ala Ser Pro Ser 
705                 710                 715                 720 


Lys Ala Thr Lys Ser 
                725 


<210>  14
<211>  727
<212>  PRT
<213>  Otolemur garnettii

<400>  14

Met Ala Gln Thr Val Gln Asn Val Thr Leu Ser Leu Thr Leu Pro Ile 
1               5                   10                  15      


Thr Cys His Ile Cys Leu Gly Lys Val Arg Gln Pro Val Ile Cys Ile 
            20                  25                  30          


Asn Asn His Val Phe Cys Ser Ile Cys Ile Asp Leu Trp Leu Lys Asn 
        35                  40                  45              


Asn Ser Gln Cys Pro Ala Cys Arg Val Pro Ile Thr Pro Ala Asn Pro 
    50                  55                  60                  


Cys Lys Glu Ile Ile Gly Gly Thr Ser Glu Ser Glu Pro Met Leu Ser 
65                  70                  75                  80  


His Thr Val Arg Lys His Leu Arg Lys Thr Arg Leu Glu Leu Leu His 
                85                  90                  95      


Lys Glu Tyr Glu Asp Glu Ile Asp Cys Leu Gln Lys Glu Val Glu Glu 
            100                 105                 110         


Leu Lys Ser Lys Asn Leu Ser Leu Glu Ser Gln Ile Lys Thr Ile Leu 
        115                 120                 125             


Asp Pro Leu Thr Leu Ile Gln Asp Asn Gln Asn Glu Asp Lys His Leu 
    130                 135                 140                 


Val Ile Asp Asn Ser Ser Lys Ile Asp Gln Glu Thr Val Ala Glu Trp 
145                 150                 155                 160 


Lys Lys Lys Leu Arg Thr Ala Asn Glu Ile Tyr Glu Lys Val Lys Asp 
                165                 170                 175     


Asp Val Asp Lys Leu Lys Glu Ala Asn Lys Lys Leu Lys Leu Glu Asn 
            180                 185                 190         


Gly Gly Leu Val Arg Glu Asn Leu Arg Leu Lys Ala Glu Val Asp Asn 
        195                 200                 205             


Arg Ser Pro Gln Lys Phe Gly Arg Phe Thr Val Ala Ala Leu Gln Ser 
    210                 215                 220                 


Lys Val Glu Gln Tyr Glu Arg Glu Thr Asn Arg Leu Lys Lys Ala Leu 
225                 230                 235                 240 


Glu Arg Ser Asp Lys Tyr Ile Glu Glu Leu Glu Ser Gln Val Ala Gln 
                245                 250                 255     


Leu Lys Lys Ser Gly Lys Glu Lys Glu Ala Met Asn Ser Ile Cys Gln 
            260                 265                 270         


Arg Ser Leu Ser Ala Asp Gly Met Gly Gly Lys Gly Ser Glu Glu Asp 
        275                 280                 285             


Val Ala Ser Lys Asn Gln Gly Asp Ser Ala Ser Lys Gln Ser Gly Ser 
    290                 295                 300                 


Ser Thr Ser Ser Ser Ser His Leu Ala Lys Ala Ser Ser Ser Lys Leu 
305                 310                 315                 320 


Ser Asp Thr Gly Ser Ala Arg Gln Glu Ser Thr Ile Asn Thr Asp Leu 
                325                 330                 335     


Asn Cys Ser Lys Asn Lys Asp Leu Tyr Gln Lys Arg Val Glu Ile Met 
            340                 345                 350         


Leu Asp Val Thr Asp Thr His Met Asp Thr Tyr Leu Glu Ser Glu Trp 
        355                 360                 365             


Asp Asn Lys Pro Ser Asp Cys Val Pro Tyr Lys Asp Glu Glu Leu Tyr 
    370                 375                 380                 


Asp Leu Pro Ala Pro Cys Thr Pro Leu Ser Leu Ser Cys Leu Gln Leu 
385                 390                 395                 400 


Ser Thr Pro Glu Asn Arg Glu Ser Ser Thr Val Lys Ala Gly Gly Ser 
                405                 410                 415     


Ile Lys His Ser Asn His Leu Arg Lys Leu Val Phe Asp Asp Phe Cys 
            420                 425                 430         


Glu Ser Ser Ser Val Ser Ile Lys Asp Ser Ser Glu Asp Asp Thr Asn 
        435                 440                 445             


Arg Asn Glu Asn Asp Asn Lys Ser Glu Cys Phe Thr Thr Pro Lys Thr 
    450                 455                 460                 


Gly Phe Trp Asp Cys Cys Ser Thr Ser Tyr Ala Gln Ser Leu Asp Phe 
465                 470                 475                 480 


Glu Ser Ser Glu Gly Asn Thr Ile Ala Asn Ser Val Gly Glu Ile Ser 
                485                 490                 495     


Ser Lys Leu Gly Glu Lys Pro Gly Ser Cys Leu Ser Lys Arg Leu Asn 
            500                 505                 510         


Ser Ile Arg Ser Phe Glu Met Asn Arg Thr Arg Thr Ser Ser Glu Ala 
        515                 520                 525             


Ser Met Asp Ala Ala Tyr Leu Asp Lys Ile Ser Glu Leu Asp Ser Met 
    530                 535                 540                 


Met Ser Glu Ser Asp Asn Ser Lys Ser Pro Cys Asn Asn Gly Phe Lys 
545                 550                 555                 560 


Ser Val Asp Leu Asp Gly Leu Ser Lys Ser Ser Gln Gly Ser Glu Phe 
                565                 570                 575     


Leu Gly Glu Ser Asp Asn Leu Glu Glu Arg Thr Lys Leu Asn Leu Ser 
            580                 585                 590         


Lys Ser Ser Leu Thr Thr Ala Asp His Leu Glu Asn Gly Asn Glu Trp 
        595                 600                 605             


Lys Pro Thr Ser Phe Phe Leu Leu Ser Pro Ser Asp Gln Glu Met Asn 
    610                 615                 620                 


Glu Asp Phe Ser Leu His Pro Ser Ser Asn Pro Gly Thr Asn Glu Thr 
625                 630                 635                 640 


Lys Pro Pro Ser Cys Leu Phe Gln Thr Glu Phe Ser Gln Gly Ile Leu 
                645                 650                 655     


Leu Ser Ser Ser His Arg Leu Phe Glu Asp Gln Arg Phe Gly Ser Ser 
            660                 665                 670         


Leu Phe Lys Met Ser Ser Glu Met His Gly Leu His Asn His Leu Gln 
        675                 680                 685             


Ser Pro Trp Ser Thr Ser Phe Val Pro Glu Lys Arg Asn Lys Asn Val 
    690                 695                 700                 


Ser Gln Ser Thr Lys Arg Lys Ile Gln Ser Ser Leu Ser Asn Ala Ser 
705                 710                 715                 720 


Pro Ser Lys Ala Thr Lys Ser 
                725         


<210>  15
<211>  725
<212>  PRT
<213>  Loxodonta africana

<400>  15

Met Ala Gln Thr Val Gln Asn Val Thr Leu Ser Leu Thr Leu Pro Ile 
1               5                   10                  15      


Thr Cys His Ile Cys Leu Gly Lys Val Arg Gln Pro Val Ile Cys Ile 
            20                  25                  30          


Asn Asn His Val Phe Cys Ser Ile Cys Ile Asp Leu Trp Leu Lys Asn 
        35                  40                  45              


Asn Ser Gln Cys Pro Ala Cys Arg Val Pro Ile Thr Pro Glu Asn Pro 
    50                  55                  60                  


Cys Lys Glu Ile Ile Gly Gly Thr Ser Glu Ser Glu Pro Met Leu Ser 
65                  70                  75                  80  


His Thr Val Arg Lys His Leu Arg Lys Thr Arg Leu Glu Leu Leu His 
                85                  90                  95      


Lys Glu Tyr Glu Asp Glu Ile Asp Cys Leu Gln Lys Glu Val Glu Glu 
            100                 105                 110         


Leu Lys Ser Lys Asn Leu Ser Leu Glu Ser Gln Ile Lys Thr Ile Leu 
        115                 120                 125             


Asp Pro Leu Thr Leu Met Gln Gly Asn Gln Asn Glu Asp Lys His Thr 
    130                 135                 140                 


Val Ala Asp Asn Pro Ser Lys Ile Asp Ser Glu Ala Val Ala Glu Trp 
145                 150                 155                 160 


Lys Lys Lys Leu Arg Thr Ala Asn Glu Ile Tyr Glu Lys Val Lys Asp 
                165                 170                 175     


Asp Val Asp Lys Leu Lys Glu Ala Asn Lys Lys Leu Lys Leu Glu Asn 
            180                 185                 190         


Gly Gly Leu Val Arg Glu Asn Leu Arg Leu Lys Ala Glu Val Asp Asn 
        195                 200                 205             


Arg Ser Pro Gln Lys Phe Gly Arg Phe Thr Val Ala Ala Leu Gln Ser 
    210                 215                 220                 


Lys Val Glu Gln Tyr Glu Arg Glu Thr Asn Arg Leu Lys Lys Ala Leu 
225                 230                 235                 240 


Glu Arg Ser Asp Lys Tyr Ile Glu Glu Leu Glu Ser Gln Val Ala Gln 
                245                 250                 255     


Leu Lys Asn Ser Ser Asp Glu Lys Glu Ala Val Asn Ser Ile Cys Gln 
            260                 265                 270         


Arg Val Leu Ser Thr Asp Gly Ser Gly Asn Thr Gly Ser Glu Glu Asp 
        275                 280                 285             


Met Ala Ser Lys Ser Gln Gly Asp Gly Ala Arg Lys Gln Pro Gly Ser 
    290                 295                 300                 


Ser Thr Ser Ser Ser Ser His Leu Ala Lys Pro Ser Ser Ser Arg Leu 
305                 310                 315                 320 


Ser Asp Thr Ser Ser Val Arg Gln Glu Ser Thr Ser Lys Thr Glu Ser 
                325                 330                 335     


Asn His Ser Asn Lys Asp Leu Tyr Gln Lys Gln Val Glu Ile Met Leu 
            340                 345                 350         


Asp Val Thr Asp Thr Ser Met Asp Thr Tyr Leu Glu Ser Glu Trp Gly 
        355                 360                 365             


Asn Lys Ala Ser Glu Cys Val Pro Tyr Lys Asp Glu Glu Leu Tyr Asp 
    370                 375                 380                 


Leu Pro Ala Pro Cys Thr Pro Leu Ser Leu Ser Cys Leu Gln Leu Ser 
385                 390                 395                 400 


Thr Pro Glu Thr Arg Glu Ser Ser Val Val Lys Ala Gly Gly Ser Lys 
                405                 410                 415     


Lys His Ser Asn His Leu Arg Lys Leu Val Phe Asp Asp Phe Cys Asp 
            420                 425                 430         


Ser Pro Asn Val Cys Asn Lys Asp Ser Ser Gly Asp Ala Ile Ser Arg 
        435                 440                 445             


Ser Glu Asn Glu Lys Lys Ser Asp Cys Phe Thr Ser Pro Lys Thr Arg 
    450                 455                 460                 


Phe Trp Asp Cys Cys Ser Thr Ser Tyr Ala Gln Ser Leu Gly Phe Glu 
465                 470                 475                 480 


Ser Ser Glu Gly Asn Thr Ile Ala Asn Ser Val Gly Glu Met Ser Ser 
                485                 490                 495     


Lys Ser Ser Glu Lys Ser Gly Ser Cys Leu Ser Lys Arg Leu Asn Ser 
            500                 505                 510         


Ile Arg Ser Phe Glu Met Asn Arg Thr Arg Thr Ser Ser Glu Ala Ser 
        515                 520                 525             


Met Asp Ala Ala Tyr Leu Asp Lys Ile Ser Glu Leu Asp Ser Met Met 
    530                 535                 540                 


Ser Glu Ser Asp Asn Ser Lys Ser Pro Cys Asn Asn Gly Phe Lys Ser 
545                 550                 555                 560 


Val Asp Leu Asp Gly Leu Ser Lys Ser Ala Gln Ser Thr Glu Phe Leu 
                565                 570                 575     


Asp Glu Pro Asp Lys Leu Glu Glu Arg Thr Lys Pro Asn Leu Ser Lys 
            580                 585                 590         


Gly Ser Leu Thr Thr Asp Gln Leu Glu Asn Glu Asn Glu Trp Lys Ser 
        595                 600                 605             


Thr Ser Phe Phe Leu Leu Pro Pro Ser Asp Gln Glu Met Asn Glu Asp 
    610                 615                 620                 


Phe Ser Leu His Pro Ser Ser Asn Pro Gly Thr Asn Glu Ile Lys Pro 
625                 630                 635                 640 


Pro Ser Cys Leu Phe Gln Thr Glu Phe Ser Gln Asn Val Leu Leu Ser 
                645                 650                 655     


Ser Ser His Gln Leu Phe Glu Asp Gln Arg Phe Gly Ser Ser Leu Phe 
            660                 665                 670         


Lys Met Ser Ser Glu Met His Gly Leu His Asn His Leu Gln Ser Pro 
        675                 680                 685             


Trp Ser Thr Ser Phe Val Ala Glu Lys Arg Asn Lys Asn Val Asn His 
    690                 695                 700                 


Ser Ala Lys Arg Lys Ile Gln Ser Ser Leu Ser Asn Ala Ser Pro Ser 
705                 710                 715                 720 


Lys Ala Thr Lys Ser 
                725 


<210>  16
<211>  716
<212>  PRT
<213>  Myotis lucifugus

<400>  16

Met Ala Gln Thr Val Gln Asn Val Thr Leu Ser Leu Thr Leu Pro Ile 
1               5                   10                  15      


Thr Cys His Ile Cys Leu Gly Lys Val Arg Gln Pro Val Ile Cys Ile 
            20                  25                  30          


Asn Asn His Val Phe Cys Ser Ile Cys Ile Asp Leu Trp Leu Lys Asn 
        35                  40                  45              


Asn Ser Gln Cys Pro Ala Cys Arg Val Pro Ile Thr Pro Glu Asn Pro 
    50                  55                  60                  


Cys Lys Glu Ile Ile Gly Gly Thr Ser Glu Ser Glu Pro Met Leu Ser 
65                  70                  75                  80  


His Thr Val Arg Lys His Leu Arg Lys Thr Arg Leu Glu Leu Leu His 
                85                  90                  95      


Lys Glu Tyr Glu Asp Glu Ile Asp Cys Leu Gln Lys Glu Val Glu Glu 
            100                 105                 110         


Leu Lys Asn Lys Asn Leu Ser Leu Glu Ser Gln Ile Lys Thr Ile Leu 
        115                 120                 125             


Asp Pro Leu Thr Leu Met Gln Gly Asn Gln Asn Glu Glu Lys His Pro 
    130                 135                 140                 


Val Ala Asp Asn Ser Ser Lys Ile Asp Pro Glu Thr Val Ala Glu Trp 
145                 150                 155                 160 


Lys Lys Lys Leu Arg Thr Ala Asn Glu Ile Tyr Glu Lys Val Lys Asp 
                165                 170                 175     


Asp Val Asp Lys Leu Lys Glu Ala Asn Lys Lys Leu Lys Leu Glu Asn 
            180                 185                 190         


Gly Gly Leu Met Arg Glu Asn Leu Arg Leu Lys Ala Glu Val Asp Asn 
        195                 200                 205             


Arg Ser Pro Gln Lys Phe Gly Arg Phe Thr Val Ala Ala Leu Gln Ser 
    210                 215                 220                 


Lys Val Glu Gln Tyr Glu Arg Glu Thr Asn Arg Leu Lys Lys Ala Leu 
225                 230                 235                 240 


Glu Arg Ser Asp Lys Tyr Ile Glu Glu Leu Glu Ser Gln Val Ala Gln 
                245                 250                 255     


Leu Lys Asn Ser Ser Glu Glu Lys Glu Ala Met Asn Ser Ile Cys Gln 
            260                 265                 270         


Arg Ala Leu Ser Thr Asp Gly Lys Gly Cys Lys Gly Ser Glu Glu Asp 
        275                 280                 285             


Met Ala Ser Thr Asn Gln Gly Asp Gly Ala Arg Lys Gln Leu Gly Ser 
    290                 295                 300                 


Ser Thr Pro Ser Ser His Leu Thr Gln Pro Ser Asn Ser Ser Ala Arg 
305                 310                 315                 320 


Gln Glu Ser Thr Ser Lys Thr Glu Leu Asn Cys Ser Lys Asn Lys Asp 
                325                 330                 335     


Leu Tyr Gln Lys Gln Val Glu Ile Met Leu Gly Val Thr Asp Ala Ser 
            340                 345                 350         


Met Asp Thr Tyr Leu Glu Arg Glu Trp Gly Asn Lys Pro Thr Asp Ser 
        355                 360                 365             


Thr Pro Tyr Lys Asp Glu Leu Tyr Asp Leu Pro Ala Pro Cys Thr Pro 
    370                 375                 380                 


Leu Ser Leu Ser Cys Leu Gln Leu Ser Thr Pro Glu Asn Arg Glu Ser 
385                 390                 395                 400 


Ser Met Ala Lys Ala Gly Ser Ser Lys Lys His Ser Asn His Leu Arg 
                405                 410                 415     


Lys Leu Val Phe Asp Asp Phe Cys Asn Ser Thr Asn Val Cys Asn Lys 
            420                 425                 430         


Asp Ser Ser Glu Asp Asp Lys Ser Glu Asn Glu Lys Lys Ser Glu Cys 
        435                 440                 445             


Phe Thr Ser Pro Lys Thr Gly Phe Trp Asp Cys Cys Ser Thr Ser Tyr 
    450                 455                 460                 


Ala Gln Ser Leu Asp Phe Glu Ser Ala Glu Gly Asn Thr Ile Ala Asn 
465                 470                 475                 480 


Ser Val Gly Glu Ile Ser Ser Lys Leu Ser Glu Lys Ser Gly Ser Cys 
                485                 490                 495     


Leu Ser Lys Arg Leu Asn Ser Ile Arg Ser Phe Glu Met Asn Arg Thr 
            500                 505                 510         


Arg Thr Ser Ser Glu Ala Ser Met Asp Ala Ala Tyr Leu Asp Lys Ile 
        515                 520                 525             


Ser Glu Leu Asp Ser Met Met Ser Glu Ser Asp Asn Ser Lys Ser Pro 
    530                 535                 540                 


Cys Asn Asn Gly Phe Lys Ser Val Asp Leu Asp Gly Leu Ser Lys Ser 
545                 550                 555                 560 


Ser Gln Gly Ser Glu Phe Leu Glu Glu Pro Asp Lys Leu Glu Glu Arg 
                565                 570                 575     


Thr Lys Pro Asn Leu Ser Lys Gly Ser Leu Thr Ser Asp Gln Leu Glu 
            580                 585                 590         


Asn Gly Asn Glu Trp Lys Pro Ser Ser Phe Phe Leu Leu Ser Pro Ser 
        595                 600                 605             


Asp Gln Glu Met Ser Glu Glu Phe Ser Leu His Pro Ser Ser Asn Ser 
    610                 615                 620                 


Gly Thr Asn Glu Leu Lys Pro Pro Ser Cys Leu Phe Gln Thr Glu Phe 
625                 630                 635                 640 


Ser Glu Gly Val Leu Leu Ser Ser Ser His Arg Leu Phe Glu Asp Gln 
                645                 650                 655     


Arg Phe Gly Ser Ser Leu Phe Lys Met Ser Ser Glu Met Gln Gly Leu 
            660                 665                 670         


Pro Asn His Leu Gln Ser Pro Trp Ser Thr Ser Phe Val Pro Glu Lys 
        675                 680                 685             


Lys Asn Lys Asn Val Asn Gln Ser Thr Lys Arg Lys Ile Gln Ser Ser 
    690                 695                 700                 


Leu Ser Asn Ala Ser Pro Ser Lys Ala Thr Lys Ser 
705                 710                 715     


<210>  17
<211>  724
<212>  PRT
<213>  Heterocephalus glaber

<400>  17

Met Ala Gln Thr Val Gln Asn Val Thr Leu Ser Leu Thr Leu Pro Ile 
1               5                   10                  15      


Thr Cys His Ile Cys Leu Gly Lys Val Arg Gln Pro Val Ile Cys Ile 
            20                  25                  30          


Asn Asn His Val Phe Cys Ser Ile Cys Ile Asp Leu Trp Leu Lys Asn 
        35                  40                  45              


Asn Ser Gln Cys Pro Ala Cys Arg Val Pro Ile Thr Pro Glu Asn Pro 
    50                  55                  60                  


Cys Lys Glu Ile Ile Gly Gly Thr Ser Glu Ser Glu Pro Met Leu Ser 
65                  70                  75                  80  


His Ala Val Arg Lys His Leu Arg Lys Thr Arg Leu Glu Leu Leu His 
                85                  90                  95      


Lys Glu Tyr Glu Asp Glu Ile Asp Cys Leu Gln Lys Glu Val Glu Glu 
            100                 105                 110         


Leu Lys Ser Lys Asn Leu Ser Leu Glu Ser Gln Ile Lys Ala Ile Leu 
        115                 120                 125             


Asp Pro Leu Thr Leu Met Gln Gly Asn Gln Asn Glu Asp Lys His Pro 
    130                 135                 140                 


Val Ala Asp Asn Ser Ser Lys Ile Asp Leu Glu Thr Val Glu Glu Trp 
145                 150                 155                 160 


Lys Lys Lys Leu Arg Thr Ala Asn Glu Ile Tyr Glu Lys Val Lys Asp 
                165                 170                 175     


Asp Val Asp Lys Leu Lys Glu Ala Asn Lys Lys Leu Lys Leu Glu Asn 
            180                 185                 190         


Gly Gly Leu Val Arg Glu Asn Leu Arg Leu Lys Ala Glu Val Asp Asn 
        195                 200                 205             


Arg Ser Pro Gln Lys Phe Gly Arg Phe Thr Val Ala Ala Leu Gln Ser 
    210                 215                 220                 


Lys Val Glu Gln Tyr Glu Arg Glu Thr Ser Arg Leu Lys Lys Ala Leu 
225                 230                 235                 240 


Glu Arg Ser Asp Lys Tyr Ile Glu Glu Leu Glu Ser Gln Val Ala Gln 
                245                 250                 255     


Leu Lys Thr Ser Gly Glu Glu Lys Glu Ala Met Asp Ala Ile Cys Gln 
            260                 265                 270         


Arg Ala Leu Ser Ala Asp Gly Lys Gly Gly Ser Lys Glu Asp Val Glu 
        275                 280                 285             


Ser Asn Ser Gln Gly Asp Ser Ala Arg Lys Gln Pro Arg Leu Ser Thr 
    290                 295                 300                 


Ser Ser Ser Ser Asn Leu Ala Lys Pro Cys Ile Ser Arg Leu Ser Asp 
305                 310                 315                 320 


Thr Ser Thr Ala Arg Gln Glu Ser Thr Ser Lys Thr Glu Pro Asn His 
                325                 330                 335     


Pro Lys Asn Lys Asp Leu Tyr Gln Lys Pro Val Glu Ile Met Leu Asp 
            340                 345                 350         


Val Thr Asp Thr Ser Met Asp Thr Tyr Leu Glu Gly Glu Trp Ser Asn 
        355                 360                 365             


Lys Pro Ser Asn Cys Val Pro Tyr Lys Asp Glu Glu Leu Tyr Asp Leu 
    370                 375                 380                 


Pro Ala Pro Cys Thr Pro Leu Ser Leu Ser Cys Leu Gln Leu Asn Thr 
385                 390                 395                 400 


Pro Glu Asn Arg Glu Ser Ser Val Val Lys Ala Gly Gly Ser Lys Lys 
                405                 410                 415     


His Ser Asn His Leu Arg Lys Leu Val Phe Asp Asp Phe Cys Asp Ser 
            420                 425                 430         


Ser Asn Val Cys Thr Lys Glu Cys Ser Glu Ala Asp Ile Ser Arg Asn 
        435                 440                 445             


Glu Asn Glu Lys Lys Ser Glu Cys Phe Ala Ser Pro Lys Thr Gly Phe 
    450                 455                 460                 


Trp Asp Cys Cys Ser Thr Ser Tyr Ala Gln Ser Leu Asp Phe Glu Asn 
465                 470                 475                 480 


Ser Glu Gly Asn Ile Ile Ala Asn Ser Val Gly Glu Ile Cys Pro Lys 
                485                 490                 495     


Leu Ile Glu Lys Ala Ser Ser Cys Leu Ser Lys Arg Leu Asn Ser Ile 
            500                 505                 510         


Arg Ser Phe Glu Met Asn Arg Thr Arg Thr Ser Ser Glu Ala Ser Met 
        515                 520                 525             


Asp Ala Ala Tyr Leu Asp Lys Ile Ser Glu Leu Asp Ser Met Met Ser 
    530                 535                 540                 


Glu Ser Asp Asn Ser Lys Ser Pro Cys Asn Asn Gly Phe Lys Ser Val 
545                 550                 555                 560 


Asp Leu Asp Gly Leu Ser Lys Ser Ser Gln Gly Asn Glu Phe Leu Glu 
                565                 570                 575     


Glu Pro Val Lys Leu Glu Glu Arg Thr Glu Leu Lys Leu Arg Lys Gly 
            580                 585                 590         


Ser Leu Thr Ala Asp Gln Leu Glu Asn Gly Asn Glu Trp Lys Pro Thr 
        595                 600                 605             


Ser Phe Phe Leu Leu Ser Pro Ser Asp Gln Glu Met Asn Glu Asp Phe 
    610                 615                 620                 


Ala Leu His Pro Thr Ser Asn Pro Glu Thr Asn Glu Ile Lys Pro Pro 
625                 630                 635                 640 


Ser Cys Leu Phe Gln Pro Glu Phe Ser Gln Gly Val Leu Leu Ser Ser 
                645                 650                 655     


Ser His Gly Leu Phe Glu Asp Gln Arg Phe Gly Ser Ser Leu Phe Lys 
            660                 665                 670         


Leu Ser Ser Glu Met His Ser Leu His Asn His Leu Gln Ser Pro Trp 
        675                 680                 685             


Ser Ala Ser Phe Val Pro Glu Lys Arg Asn Lys Asn Val Asn Gln Ser 
    690                 695                 700                 


Thr Lys Arg Lys Ile His Ser Ser Leu Ser Asn Ala Ser Pro Ser Lys 
705                 710                 715                 720 


Ala Thr Lys Ser 
                


<210>  18
<211>  751
<212>  PRT
<213>  Pteropus alecto

<400>  18

Met Ala Leu Leu Gly Cys Arg Ser Arg Pro Arg Ala Val Pro Val Ala 
1               5                   10                  15      


Ala Arg Ile Arg Gly Arg Arg Asp Phe Arg Val Gly Gly Ile Leu Asn 
            20                  25                  30          


Ala Ala Met Ala Gln Thr Val Gln Asn Val Thr Leu Ser Leu Thr Leu 
        35                  40                  45              


Pro Ile Thr Cys His Ile Cys Leu Gly Lys Val Arg Gln Pro Val Ile 
    50                  55                  60                  


Cys Ile Asn Asn His Val Phe Cys Ser Val Cys Ile Asp Leu Trp Leu 
65                  70                  75                  80  


Lys Asn Asn Ser Gln Cys Pro Ala Cys Arg Val Pro Ile Thr Pro Glu 
                85                  90                  95      


Asn Pro Cys Lys Glu Ile Ile Gly Gly Thr Ser Glu Ser Glu Pro Met 
            100                 105                 110         


Leu Ser His Thr Val Arg Lys His Leu Arg Lys Thr Arg Leu Glu Leu 
        115                 120                 125             


Leu His Lys Glu Tyr Glu Asp Glu Ile Asp Cys Leu Gln Lys Glu Met 
    130                 135                 140                 


Glu Glu Leu Lys Ser Lys Asn Leu Ser Leu Glu Ser Gln Ile Lys Thr 
145                 150                 155                 160 


Ile Leu Asp Pro Leu Ile Phe Thr Gln Gly Asn Gln Ser Glu Asp Lys 
                165                 170                 175     


His Pro Val Val Asp Asn Pro Ser Lys Ile Asp Pro Glu Thr Val Ala 
            180                 185                 190         


Glu Trp Lys Lys Lys Leu Arg Thr Ala Asn Glu Ile Tyr Glu Lys Val 
        195                 200                 205             


Lys Asp Asp Val Asp Lys Leu Lys Glu Ala Asn Lys Lys Leu Lys Leu 
    210                 215                 220                 


Glu Asn Gly Gly Leu Met Arg Glu Asn Leu Arg Leu Lys Ala Glu Val 
225                 230                 235                 240 


Asp Asn Arg Ser Pro Gln Lys Phe Gly Arg Phe Thr Ile Ala Ala Leu 
                245                 250                 255     


Gln Ser Lys Val Glu Gln Tyr Glu Arg Glu Thr Asn Arg Leu Lys Lys 
            260                 265                 270         


Ala Leu Glu Arg Ser Asp Lys Tyr Ile Glu Glu Leu Glu Ser Gln Ile 
        275                 280                 285             


Ala Gln Leu Lys Asn Ser Ser Glu Glu Lys Glu Ala Met Asn Ser Ile 
    290                 295                 300                 


Cys Gln Asn Thr Leu Ser Thr Asp Asp Lys Gly Ser Lys Gly Ser Lys 
305                 310                 315                 320 


Glu Asp Met Pro Ser Lys Asn Gln Gly Asp Gly Ala Arg Lys Gln Leu 
                325                 330                 335     


Cys Ser Ala Thr Ser Ser Ser His Leu Ala Gln Pro Ser Asn Ser Ser 
            340                 345                 350         


Ala Arg Gln Glu Ser Thr Ser Lys Thr Glu Pro Asn Cys Ser Lys Asn 
        355                 360                 365             


Lys Asp Leu Tyr Gln Lys Gln Val Glu Ile Met Leu Asp Val Thr Asp 
    370                 375                 380                 


Thr Ser Met Asp Thr Tyr Leu Glu Arg Glu Trp Gly Asn Lys Pro Ser 
385                 390                 395                 400 


Asp Cys Ala Pro Tyr Lys Ala Glu Glu Leu Tyr Asp Leu Pro Ala Pro 
                405                 410                 415     


Cys Thr Pro Leu Ser Leu Ser Cys Leu Gln Leu Ser Thr Pro Glu Asn 
            420                 425                 430         


Arg Glu Asn Ser Val Gly Lys Ala Gly Cys Ser Lys Asn His Ser Asn 
        435                 440                 445             


His Leu Arg Lys Leu Val Phe Asp Asp Phe Cys Asp Ser Pro Asn Val 
    450                 455                 460                 


Cys Asn Lys Glu Ser Ser Glu Asp Gly Arg Ser Glu Asn Glu Lys Lys 
465                 470                 475                 480 


Ser Glu Cys Phe Pro Ser Pro Lys Thr Gly Phe Trp Asp Cys Cys Ser 
                485                 490                 495     


Thr Ser Tyr Ala Gln Ser Leu Asp Phe Glu Asn Ser Glu Gly Asn Leu 
            500                 505                 510         


Ile Ala Asn Ser Val Gly Glu Ile Ser Ser Lys Phe Ser Glu Lys Ser 
        515                 520                 525             


Gly Ser Cys Leu Ser Lys Arg Leu Asn Ser Ile Arg Ser Phe Glu Met 
    530                 535                 540                 


Asn Arg Thr Arg Thr Ser Ser Glu Ala Ser Met Asp Ala Ala Tyr Leu 
545                 550                 555                 560 


Asp Lys Ile Ser Glu Leu Asp Ser Met Met Ser Glu Ser Asp Asn Ser 
                565                 570                 575     


Lys Ser Pro Cys Asn Asn Gly Phe Lys Ser Val Asp Leu Asp Gly Leu 
            580                 585                 590         


Ser Lys Ser Ser Gln Gly Ser Glu Phe Leu Glu Glu Pro Asp Glu Leu 
        595                 600                 605             


Glu Glu Arg Thr Lys Pro Asp Leu Ser Lys Gly Ser Leu Thr Thr Gly 
    610                 615                 620                 


Gln Leu Glu Asn Gly Asn Glu Trp Lys Pro Thr Ser Tyr Phe Phe Leu 
625                 630                 635                 640 


Ser Pro Ser Asp Gln Glu Met Asn Glu Asp Phe Ser Leu His Pro Ser 
                645                 650                 655     


Ser Asp Ser Gly Thr Thr Glu Ile Lys Pro Pro Ser Cys Leu Phe Gln 
            660                 665                 670         


Thr Glu Phe Ser Gln Ser Val Leu Leu Ser Ser Ser His Arg Leu Phe 
        675                 680                 685             


Glu Asp Gln Arg Phe Glu Ser Ser Leu Phe Lys Met Ser Ser Glu Met 
    690                 695                 700                 


His Gly Leu His Asn His Leu Gln Ser Pro Trp Ser Thr Ser Phe Val 
705                 710                 715                 720 


Pro Glu Lys Arg Asn Lys Asn Val Asn Gln Ser Thr Lys Arg Lys Ile 
                725                 730                 735     


Gln Ser Ser Leu Ser Asn Ala Ser Pro Ser Lys Ala Thr Lys Ser 
            740                 745                 750     


<210>  19
<211>  717
<212>  PRT
<213>  Bos grunniens

<400>  19

Met Ala Gln Thr Val Gln Asn Val Thr Leu Ser Leu Thr Leu Pro Ile 
1               5                   10                  15      


Thr Cys His Ile Cys Leu Gly Lys Val Arg Gln Pro Val Ile Cys Ile 
            20                  25                  30          


Asn Asn His Val Phe Cys Ser Val Cys Ile Asp Leu Trp Leu Lys Asn 
        35                  40                  45              


Asn Ser Gln Cys Pro Ala Cys Arg Val Pro Ile Thr Pro Glu Asn Pro 
    50                  55                  60                  


Cys Lys Glu Ile Ile Gly Gly Thr Ser Glu Ser Glu Pro Met Leu Ser 
65                  70                  75                  80  


His Thr Val Arg Lys His Leu Arg Lys Thr Arg Leu Glu Leu Leu His 
                85                  90                  95      


Lys Glu Tyr Glu Asp Glu Ile Asp Cys Leu Gln Lys Glu Val Asp Glu 
            100                 105                 110         


Leu Lys Ser Lys Asn Leu Ser Leu Glu Ser Gln Ile Lys Thr Ile Leu 
        115                 120                 125             


Asp Pro Leu Thr Leu Met Gln Gly Asn Gln Asn Glu Asp Lys Leu Pro 
    130                 135                 140                 


Val Ala Asp Asn Pro Ser Lys Ile Asp Pro Glu Thr Val Ala Glu Trp 
145                 150                 155                 160 


Lys Lys Arg Leu Arg Thr Ala Asn Glu Ile Tyr Glu Lys Val Lys Asp 
                165                 170                 175     


Asp Val Asp Lys Leu Lys Glu Ala Asn Lys Lys Leu Lys Leu Glu Asn 
            180                 185                 190         


Gly Gly Leu Val Arg Glu Asn Leu Arg Leu Lys Ala Glu Val Asp Asn 
        195                 200                 205             


Arg Ser Pro Gln Lys Phe Gly Arg Phe Thr Val Ala Ala Leu Gln Ser 
    210                 215                 220                 


Lys Val Glu Gln Tyr Glu Arg Glu Thr Asn Arg Leu Lys Lys Ala Leu 
225                 230                 235                 240 


Glu Arg Ser Asp Lys Tyr Ile Glu Glu Leu Glu Ser Gln Ile Thr Gln 
                245                 250                 255     


Leu Lys Asn Ser Ser Asp Glu Lys Glu Ala Met Asn Ala Ile Cys Gln 
            260                 265                 270         


Arg Ala Leu Ser Thr Asp Gly Lys Gly Ser Lys Gly Thr Glu Glu Asp 
        275                 280                 285             


Met Ala Ser Lys Asn Gln Gly Asp Gly Ala Arg Lys Gln Leu Gly Ser 
    290                 295                 300                 


Ala Thr Ser Ser Ser His Leu Ala Lys Pro Ser Ser Ser Ser Val Arg 
305                 310                 315                 320 


Gln Glu Gly Thr Ser Lys Thr Glu Pro Asn Cys Ser Lys Asn Gln Asp 
                325                 330                 335     


Leu Tyr Gln Lys Arg Val Glu Thr Met Leu Thr Val Thr Asp Thr Ser 
            340                 345                 350         


Met Asp Thr Tyr Leu Glu Arg Glu Trp Gly Asn Lys Pro Ser Asp Cys 
        355                 360                 365             


Met Pro Tyr Lys Asp Glu Glu Leu Tyr Asp Leu Pro Ala Ser Cys Ala 
    370                 375                 380                 


Pro Leu Ser Leu Ser Cys Leu Gln Leu Asn Thr Pro Asp Asn Arg Glu 
385                 390                 395                 400 


Ser Ser Val Val Lys Ala Gly Gly Ser Lys Lys Gln Ser Asn His Leu 
                405                 410                 415     


Arg Lys Leu Met Phe Asp Glu Phe Cys Asp Ser Pro Asn Val Cys Asn 
            420                 425                 430         


Lys Asp Ser Ser Glu Asp Asp Arg Ser Glu Ser Glu Lys Lys Ser Glu 
        435                 440                 445             


Cys Phe Thr Ser Pro Lys Thr Gly Phe Trp Asp Cys Cys Ser Thr Ser 
    450                 455                 460                 


Tyr Ala Pro Ser Leu Asp Phe Glu Asn Ser Glu Glu Asn Thr Ile Ala 
465                 470                 475                 480 


Asn Cys Val Gly Glu Ile Ser Ser Lys Leu Ser Glu Lys Pro Gly Ser 
                485                 490                 495     


Cys Leu Ser Lys Arg Leu Asn Ser Leu Arg Ser Phe Glu Met Asn Arg 
            500                 505                 510         


Thr Arg Thr Ser Ser Glu Ala Ser Met Asp Ala Ala Tyr Leu Asp Lys 
        515                 520                 525             


Ile Ser Glu Leu Asp Ser Met Met Ser Glu Ser Asp Asn Ser Lys Ser 
    530                 535                 540                 


Pro Cys Asn Asn Gly Phe Lys Ser Leu Asp Leu Asp Gly Leu Ser Lys 
545                 550                 555                 560 


Ser Ser Gln Cys Ser Glu Phe Leu Glu Glu Thr Asp Lys Leu Glu Glu 
                565                 570                 575     


Arg Thr Lys Pro Asn Leu Ser Lys Gly Ser Leu Thr Thr Asp Gln Leu 
            580                 585                 590         


Glu Asn Gly Asn Glu Trp Lys Pro Asn Ser Phe Phe Leu Leu Ser Pro 
        595                 600                 605             


Ser Asp Gln Glu Met Asn Glu Asp Phe Ser Leu His Ser Ser Ser Asn 
    610                 615                 620                 


Pro Gly Thr Asn Glu Ile Lys Pro Pro Ser Cys Leu Phe Gln Thr Glu 
625                 630                 635                 640 


Phe Ser Gln Gly Val Leu Leu Ser Ser Thr Asn Arg Leu Phe Glu Asp 
                645                 650                 655     


Gln Arg Phe Gly Ser Ser Leu Phe Lys Met Ser Ser Glu Met Pro Gly 
            660                 665                 670         


Leu His Thr His Leu Gln Ser Pro Trp Ser Thr Ser Phe Val Pro Glu 
        675                 680                 685             


Lys Arg Asn Lys Asn Val Asn Gln Ser Ala Lys Arg Lys Ile Gln Ser 
    690                 695                 700                 


Ser Leu Ser Asn Ala Ser Pro Ser Lys Ala Thr Lys Ser 
705                 710                 715         


<210>  20
<211>  717
<212>  PRT
<213>  Bos taurus

<400>  20

Met Ala Gln Thr Val Gln Asn Val Thr Leu Ser Leu Thr Leu Pro Ile 
1               5                   10                  15      


Thr Cys His Ile Cys Leu Gly Lys Val Arg Gln Pro Val Ile Cys Ile 
            20                  25                  30          


Asn Asn His Val Phe Cys Ser Val Cys Ile Asp Leu Trp Leu Lys Asn 
        35                  40                  45              


Asn Ser Gln Cys Pro Ala Cys Arg Val Pro Ile Thr Pro Glu Asn Pro 
    50                  55                  60                  


Cys Lys Glu Ile Ile Gly Gly Thr Ser Glu Ser Glu Pro Met Leu Ser 
65                  70                  75                  80  


His Thr Val Arg Lys His Leu Arg Lys Thr Arg Leu Glu Leu Leu His 
                85                  90                  95      


Lys Glu Tyr Glu Asp Glu Ile Asp Cys Leu Gln Lys Glu Val Asp Glu 
            100                 105                 110         


Leu Lys Ser Lys Asn Leu Ser Leu Glu Ser Gln Ile Lys Thr Ile Leu 
        115                 120                 125             


Asp Pro Leu Thr Leu Met Gln Gly Asn Gln Asn Glu Asp Lys Leu Pro 
    130                 135                 140                 


Val Ala Asp Asn Pro Ser Lys Ile Asp Pro Glu Thr Val Ala Glu Trp 
145                 150                 155                 160 


Lys Lys Arg Leu Arg Thr Ala Asn Glu Ile Tyr Glu Lys Val Lys Asp 
                165                 170                 175     


Asp Val Asp Lys Leu Lys Glu Ala Asn Lys Lys Leu Lys Leu Glu Asn 
            180                 185                 190         


Gly Gly Leu Val Arg Glu Asn Leu Arg Leu Lys Ala Glu Val Asp Asn 
        195                 200                 205             


Arg Ser Pro Gln Lys Phe Gly Arg Phe Thr Val Ala Ala Leu Gln Ser 
    210                 215                 220                 


Lys Val Glu Gln Tyr Glu Arg Glu Thr Asn Arg Leu Lys Lys Ala Leu 
225                 230                 235                 240 


Glu Arg Ser Asp Lys Tyr Ile Glu Glu Leu Glu Ser Gln Ile Thr Gln 
                245                 250                 255     


Leu Lys Asn Ser Ser Asp Glu Lys Glu Ala Met Asn Ala Ile Cys Gln 
            260                 265                 270         


Arg Ala Leu Ser Thr Asp Gly Lys Gly Ser Lys Gly Thr Glu Glu Asp 
        275                 280                 285             


Met Ala Ser Lys Asn Gln Gly Asp Gly Ala Arg Lys Gln Leu Gly Ser 
    290                 295                 300                 


Ala Thr Ser Ser Ser His Leu Ala Lys Pro Ser Ser Ser Ser Val Arg 
305                 310                 315                 320 


Gln Glu Gly Thr Ser Lys Thr Glu Pro Asn Cys Ser Lys Asn Gln Asp 
                325                 330                 335     


Leu Tyr Gln Lys Arg Val Glu Thr Met Leu Thr Val Thr Asp Thr Ser 
            340                 345                 350         


Met Asp Thr Tyr Leu Glu Arg Glu Trp Gly Asn Lys Pro Ser Asp Cys 
        355                 360                 365             


Met Pro Tyr Lys Asp Glu Glu Leu Tyr Asp Leu Pro Ala Ser Cys Ala 
    370                 375                 380                 


Pro Leu Ser Leu Ser Cys Leu Gln Leu Asn Thr Pro Asp Asn Arg Glu 
385                 390                 395                 400 


Ser Ser Val Val Lys Ala Gly Gly Ser Lys Lys Gln Ser Asn His Leu 
                405                 410                 415     


Arg Lys Leu Met Phe Asp Glu Phe Cys Asp Ser Pro Asn Val Cys Asn 
            420                 425                 430         


Lys Asp Ser Ser Glu Asp Asp Arg Ser Glu Ser Glu Lys Lys Ser Glu 
        435                 440                 445             


Cys Phe Thr Ser Pro Lys Thr Gly Phe Trp Asp Cys Cys Ser Thr Ser 
    450                 455                 460                 


Tyr Ala Pro Ser Leu Asp Phe Glu Asn Ser Glu Glu Asn Thr Ile Ala 
465                 470                 475                 480 


Asn Cys Val Gly Glu Ile Ser Ser Lys Leu Ser Glu Lys Pro Gly Ser 
                485                 490                 495     


Cys Leu Ser Lys Arg Leu Asn Ser Leu Arg Ser Phe Glu Met Asn Arg 
            500                 505                 510         


Thr Arg Thr Ser Ser Glu Ala Ser Met Asp Ala Ala Tyr Leu Asp Lys 
        515                 520                 525             


Ile Ser Glu Leu Asp Ser Met Met Ser Glu Ser Asp Asn Ser Lys Ser 
    530                 535                 540                 


Pro Cys Asn Asn Gly Phe Lys Ser Leu Asp Leu Asp Gly Leu Ser Lys 
545                 550                 555                 560 


Ser Ser Gln Cys Ser Glu Phe Leu Glu Glu Thr Asp Lys Leu Glu Glu 
                565                 570                 575     


Arg Thr Lys Pro Asn Leu Ser Lys Gly Ser Leu Thr Thr Asp Gln Leu 
            580                 585                 590         


Glu Asn Gly Asn Glu Trp Lys Pro Asn Ser Phe Phe Leu Leu Ser Pro 
        595                 600                 605             


Ser Asp Gln Glu Met Asn Glu Asp Phe Ser Leu His Ser Ser Ser Asn 
    610                 615                 620                 


Pro Gly Thr Asn Glu Ile Lys Pro Pro Ser Cys Leu Phe Gln Thr Glu 
625                 630                 635                 640 


Phe Ser Gln Gly Val Leu Leu Ser Ser Thr Asn Arg Leu Phe Glu Asp 
                645                 650                 655     


Gln Arg Phe Gly Ser Ser Leu Phe Lys Met Ser Ser Glu Met Pro Gly 
            660                 665                 670         


Leu His Thr His Leu Gln Ser Pro Trp Ser Thr Ser Phe Val Pro Glu 
        675                 680                 685             


Lys Arg Asn Lys Asn Val Asn Gln Ser Ala Lys Arg Lys Ile Gln Ser 
    690                 695                 700                 


Ser Leu Ser Asn Ala Ser Pro Ser Lys Ala Thr Lys Ser 
705                 710                 715         


<210>  21
<211>  723
<212>  PRT
<213>  Cavia porcellus

<400>  21

Met Ala Gln Ser Val Gln Asn Val Thr Leu Ser Leu Thr Leu Pro Ile 
1               5                   10                  15      


Thr Cys His Ile Cys Leu Gly Lys Val Arg Gln Pro Val Ile Cys Ile 
            20                  25                  30          


Asn Asn His Val Phe Cys Ser Ile Cys Ile Asp Leu Trp Leu Lys Asn 
        35                  40                  45              


Asn Ser Gln Cys Pro Ala Cys Arg Val Pro Ile Thr Pro Glu Asn Pro 
    50                  55                  60                  


Cys Lys Glu Ile Ile Gly Gly Ala Ser Glu Ser Glu Pro Met Leu Ser 
65                  70                  75                  80  


His Thr Val Arg Lys His Leu Arg Lys Thr Arg Leu Glu Leu Leu His 
                85                  90                  95      


Lys Glu Tyr Glu Asp Glu Ile Asp Cys Leu Gln Lys Glu Val Glu Glu 
            100                 105                 110         


Leu Lys Asn Lys Asn Leu Ser Leu Glu Ser Gln Ile Lys Thr Ile Leu 
        115                 120                 125             


Asp Pro Leu Thr Leu Met Gln Gly Asn Gln Asn Glu Asp Lys Leu Pro 
    130                 135                 140                 


Val Ala Asp Asn Pro Ser Lys Ile Asp Pro Gln Thr Val Ser Glu Trp 
145                 150                 155                 160 


Lys Lys Lys Leu Arg Thr Ala Asn Glu Ile Tyr Glu Lys Val Lys Asp 
                165                 170                 175     


Asp Val Asp Lys Leu Lys Glu Val Asn Lys Lys Leu Lys Leu Glu Asn 
            180                 185                 190         


Gly Gly Leu Val Arg Glu Asn Leu Arg Leu Lys Ala Glu Val Asp Asn 
        195                 200                 205             


Arg Ser Pro Gln Lys Phe Gly Arg Phe Thr Val Ala Ala Leu Gln Ser 
    210                 215                 220                 


Lys Val Glu Gln Tyr Glu Arg Glu Thr Asn Arg Leu Lys Lys Ala Leu 
225                 230                 235                 240 


Glu Arg Ser Asp Lys Tyr Ile Glu Glu Leu Glu Ser Gln Ile Ala Gln 
                245                 250                 255     


Leu Lys Asn Ser Ser Glu Glu Arg Glu Thr Met Asp Ala Ile Cys Gln 
            260                 265                 270         


Arg Ala Leu Ser Ala Asp Gly Lys Gly Gly Ser Glu Glu Asp Val Ala 
        275                 280                 285             


Ser Asn Asn Gln Gly Asp Ser Ala Arg Lys Pro Ser Ser Ser Thr Leu 
    290                 295                 300                 


Ser Ser Ser His Leu Gly Lys Leu Ser Ser Ser Arg Leu Ser Asp Thr 
305                 310                 315                 320 


Ser Ala Ala Arg Gln Glu Ile Thr Cys Lys Thr Glu Pro Asn Gln His 
                325                 330                 335     


Lys Asn Lys Asp Leu Tyr Gln Lys Gln Val Glu Ile Met Leu Asp Val 
            340                 345                 350         


Ser Asp Thr Ser Met Asn Thr Tyr Leu Glu Gly Glu Trp Gly Gly Lys 
        355                 360                 365             


Pro Ser Asn Cys Val Ala Tyr Lys Asp Glu Glu Leu Tyr Asp Leu Pro 
    370                 375                 380                 


Ala Pro Cys Thr Pro Leu Ser Leu Ser Cys Leu Gln Leu Asn Thr Pro 
385                 390                 395                 400 


Glu Asn Arg Glu Ser Ser Ala Val Lys Ala Gly Gly Ser Lys Lys His 
                405                 410                 415     


Ser Asn His Leu Arg Lys Leu Val Phe Asp Asp Phe Cys Glu Ser Pro 
            420                 425                 430         


Asn Val Cys Asn Lys Asp Cys Ser Glu Asp Asp Val Ser Arg Asn Glu 
        435                 440                 445             


Asn Glu Lys Lys Ser Glu Cys Phe Ala Pro Pro Lys Thr Ala Phe Trp 
    450                 455                 460                 


Asp Cys Cys Ser Thr Ser Tyr Ala Gln Ser Leu Asp Phe Glu Asn Ser 
465                 470                 475                 480 


Glu Gly Asn Ile Ile Ala Asn Ser Val Gly Glu Ile Pro Ser Lys Leu 
                485                 490                 495     


Ser Glu Lys Ser Thr Ser Cys Leu Ser Lys Arg Leu Asn Ser Ile Arg 
            500                 505                 510         


Ser Phe Glu Met Asn Arg Thr Arg Thr Ser Ser Glu Ala Ser Met Asp 
        515                 520                 525             


Ala Ala Tyr Leu Asp Lys Ile Ser Glu Leu Asp Ser Met Met Ser Glu 
    530                 535                 540                 


Ser Asp Asn Ser Lys Ser Pro Cys Asn Asn Gly Phe Lys Ser Val Asp 
545                 550                 555                 560 


Leu Asp Gly Leu Ser Lys Ser Ser Gln Gly Asn Asp Phe Leu Glu Glu 
                565                 570                 575     


Pro Ser Lys Leu Asp Glu Arg Thr Glu Leu Asn Leu Pro Lys Ser Ser 
            580                 585                 590         


Leu Thr Ala Asp Gln Leu Lys Asn Gly Asn Glu Trp Lys Pro Thr Ser 
        595                 600                 605             


Phe Phe Leu Leu Ser Pro Ser Asp Gln Glu Met Asn Glu Asp Phe Ser 
    610                 615                 620                 


Leu His Ser Thr Ser Asn Pro Glu Thr Asn Glu Ile Lys Pro Ser Ser 
625                 630                 635                 640 


Cys Leu Phe Gln Thr Glu Phe Ser Gln Gly Val Leu Leu Ser Ser Ser 
                645                 650                 655     


His Arg Leu Phe Glu Asp Glu Arg Phe Gly Ser Ser Leu Phe Lys Met 
            660                 665                 670         


Ser Ser Glu Met His Ser Leu His Asn His Leu Gln Ser Pro Trp Ser 
        675                 680                 685             


Ala Ser Phe Val Pro Glu Lys Arg Asn Lys Asn Val Asn Gln Ser Thr 
    690                 695                 700                 


Lys Arg Lys Ile His Ser Thr Leu Ser Asn Ala Ser Pro Ser Lys Ala 
705                 710                 715                 720 


Thr Lys Ser 
            


<210>  22
<211>  717
<212>  PRT
<213>  Sus scrofa

<400>  22

Met Ala Gln Thr Val Gln Asn Val Thr Leu Ser Leu Thr Leu Pro Ile 
1               5                   10                  15      


Thr Cys His Ile Cys Leu Gly Lys Val Arg Gln Pro Val Ile Cys Ile 
            20                  25                  30          


Asn Asn His Val Phe Cys Ser Ile Cys Ile Asp Leu Trp Leu Lys Asn 
        35                  40                  45              


Asn Ser Gln Cys Pro Ala Cys Arg Val Pro Ile Thr Pro Glu Asn Pro 
    50                  55                  60                  


Cys Lys Glu Ile Ile Gly Gly Thr Ser Glu Ser Glu Pro Met Leu Ser 
65                  70                  75                  80  


His Thr Val Arg Lys His Leu Arg Lys Thr Arg Leu Glu Leu Leu His 
                85                  90                  95      


Lys Glu Tyr Glu Asp Glu Ile Asp Cys Leu Gln Lys Glu Ile Glu Glu 
            100                 105                 110         


Leu Lys Ser Lys Asn Leu Ser Leu Glu Ser Gln Ile Lys Thr Ile Leu 
        115                 120                 125             


Asp Pro Leu Thr Leu Met Gln Gly Asn Gln Asn Glu Asp Lys His Pro 
    130                 135                 140                 


Val Ala Asp Asn Leu Ser Lys Val Asp Pro Glu Thr Val Ala Glu Trp 
145                 150                 155                 160 


Lys Lys Lys Leu Arg Thr Ala Asn Glu Ile Tyr Glu Lys Val Lys Asp 
                165                 170                 175     


Asp Val Asp Lys Leu Lys Glu Ala Asn Lys Lys Leu Lys Leu Glu Asn 
            180                 185                 190         


Gly Gly Leu Val Arg Glu Asn Leu Arg Leu Lys Ala Glu Val Asp Asn 
        195                 200                 205             


Arg Ser Pro Gln Lys Phe Gly Arg Phe Thr Val Ala Ala Leu Gln Ser 
    210                 215                 220                 


Lys Val Glu Gln Tyr Glu Arg Glu Thr Asn Arg Leu Lys Lys Ala Leu 
225                 230                 235                 240 


Glu Arg Ser Asp Lys Tyr Ile Glu Glu Leu Glu Ser Gln Ile Thr Gln 
                245                 250                 255     


Leu Lys Asn Ser Ser Asp Glu Lys Glu Ala Arg Asn Ser Ile Cys Gln 
            260                 265                 270         


Arg Ala Leu Ser Thr Asp Gly Lys Gly Asn Thr Gly Ser Glu Glu Asp 
        275                 280                 285             


Met Ala Ser Lys Asn Gln Gly Asp Gly Ala Arg Lys Gln Leu Gly Ser 
    290                 295                 300                 


Ser Thr Ser Ser Ser His Leu Ala Lys Pro Ser Ser Ser Ser Ala Arg 
305                 310                 315                 320 


Gln Glu Gly Thr Asn Lys Thr Glu Pro Ser Cys Cys Lys Asn Lys Asp 
                325                 330                 335     


Leu Tyr Gln Lys Arg Ala Glu Ile Met Leu Asp Val Thr Asp Thr Ser 
            340                 345                 350         


Met Asp Thr Tyr Leu Glu Arg Glu Trp Gly Gly Lys Pro Ser Asp Cys 
        355                 360                 365             


Val Ala Tyr Lys Asp Glu Glu Leu Tyr Asp Leu Pro Ala Pro Cys Thr 
    370                 375                 380                 


Pro Leu Ser Leu Ser Cys Leu Gln Leu Ser Thr Pro Glu Asn Arg Glu 
385                 390                 395                 400 


Ser Ser Val Val Lys Ala Gly Val Ser Lys Lys His Pro Asn His Leu 
                405                 410                 415     


Arg Lys Leu Val Phe Asp Asp Phe Cys Asp Ser Pro Gly Val Ser Asn 
            420                 425                 430         


Lys Asp Ser Ser Glu Asp Asp Arg Ser Glu Ser Glu Lys Lys Ser Glu 
        435                 440                 445             


Cys Phe Thr Ser Pro Lys Thr Gly Phe Trp Asp Cys Cys Ser Pro Ser 
    450                 455                 460                 


Tyr Thr Pro Ser Leu Asp Phe Glu Ser Ser Glu Gly Thr Ile Ala Asn 
465                 470                 475                 480 


Ser Val Gly Glu Phe Leu Lys Leu Ser Glu Lys Ser Gly Ser Cys Leu 
                485                 490                 495     


Ser Lys Arg Leu Asn Ser Ile Arg Thr Phe Glu Met Asn Arg Thr Arg 
            500                 505                 510         


Thr Ser Ser Glu Ala Ser Met Asp Ala Ala Tyr Leu Asp Lys Ile Ser 
        515                 520                 525             


Glu Leu Asp Ser Met Met Ser Glu Ser Asp Asn Ser Lys Ser Pro Cys 
    530                 535                 540                 


Asn Asn Gly Phe Lys Ser Leu Asp Leu Asp Gly Leu Ser Lys Ser Ser 
545                 550                 555                 560 


Gln Gly Ser Glu Phe Leu Glu Glu Pro Asp Lys Leu Glu Glu Arg Thr 
                565                 570                 575     


Lys Pro His Leu Ser Lys Gly Ser Leu Thr Thr Asp Gln Leu Glu Asn 
            580                 585                 590         


Gly Asn Glu Trp Lys Ser Asn Ser Phe Phe Leu Leu Ser Pro Ser Asp 
        595                 600                 605             


Gln Glu Met Asn Glu Asp Phe Ser Leu His Pro Ser Ser Asn Pro Gly 
    610                 615                 620                 


Thr Asn Glu Ile Lys Pro Pro Ser Cys Leu Phe Gln Thr Glu Phe Ser 
625                 630                 635                 640 


Gln Gly Val Leu Leu Ser Ser Ser His Arg Leu Phe Glu Asp Gln Arg 
                645                 650                 655     


Phe Gly Ser Ser Leu Phe Lys Met Ser Ser Glu Met His Gly Leu Gln 
            660                 665                 670         


Asn His Leu Gln Ser Pro Trp Ser Thr Ser Thr Ser Phe Val Pro Glu 
        675                 680                 685             


Lys Arg Asn Lys Asn Met Asn Gln Ser Thr Lys Arg Lys Ile Gln Ser 
    690                 695                 700                 


Ser Leu Ser Asn Ala Ser Pro Ser Lys Ala Thr Lys Ser 
705                 710                 715         


<210>  23
<211>  722
<212>  PRT
<213>  Mus musculus

<400>  23

Met Ala Gln Thr Val Gln Asn Val Thr Leu Ser Leu Thr Leu Pro Ile 
1               5                   10                  15      


Thr Cys His Ile Cys Leu Gly Lys Val Arg Gln Pro Val Val Cys Thr 
            20                  25                  30          


Asn Asn His Val Phe Cys Ser Ile Cys Ile Asp Leu Trp Leu Lys Asn 
        35                  40                  45              


Asn Ser Gln Cys Pro Ala Cys Arg Val Pro Ile Thr Pro Glu Asn Pro 
    50                  55                  60                  


Cys Lys Glu Ile Ile Gly Gly Thr Ser Glu Ser Glu Pro Met Leu Ser 
65                  70                  75                  80  


His Thr Val Arg Lys His Leu Arg Lys Thr Arg Leu Glu Leu Leu His 
                85                  90                  95      


Arg Glu Tyr Glu Asp Glu Ile Asp Cys Leu Gln Lys Glu Val Glu Glu 
            100                 105                 110         


Leu Lys Ser Lys Asn Leu Ser Leu Glu Ser Gln Ile Lys Thr Ile Leu 
        115                 120                 125             


Asp Pro Leu Ala Leu Met Gln Gly Ser Gln Asn Glu Asp Lys His Pro 
    130                 135                 140                 


Leu Ala Asp Asn Pro Ser Lys Met Asp Pro Asp Ser Val Val Glu Trp 
145                 150                 155                 160 


Lys Lys Lys Leu Arg Thr Ala Asn Glu Ile Tyr Glu Lys Val Lys Asp 
                165                 170                 175     


Asp Val Asp Lys Leu Lys Glu Ala Asn Lys Lys Leu Lys Leu Glu Asn 
            180                 185                 190         


Gly Gly Leu Leu Arg Glu Asn Leu Arg Leu Lys Ala Glu Val Asp Asn 
        195                 200                 205             


Arg Ser Pro Gln Lys Phe Gly Arg Phe Thr Val Ala Ala Leu Gln Ser 
    210                 215                 220                 


Lys Val Glu Gln Tyr Glu Arg Glu Thr Asn Arg Leu Lys Lys Ala Leu 
225                 230                 235                 240 


Glu Arg Ser Asp Lys Tyr Ile Glu Glu Leu Glu Ser Gln Val Ala His 
                245                 250                 255     


Leu Lys His Ser Glu Glu Ala Lys Glu Asp Val Asp Ala Leu Cys Gln 
            260                 265                 270         


Arg Ala Pro Ser Ala Asp Ser Lys Gly Pro Asn Gly Ser Asp Glu Leu 
        275                 280                 285             


Gly Pro Pro Lys Asn Gln Ser Asp Ser Ala Arg Lys Gln Ala Gly Ser 
    290                 295                 300                 


Ala Ser Ala Ser His Leu Ala Ser Pro Ser Ser Ser Arg Leu Ala Asp 
305                 310                 315                 320 


Ser Gly Ser Val Arg Gln Glu Ser Thr Ser Arg Thr Glu Pro Asn Cys 
                325                 330                 335     


Pro Gln Asn Lys Asp Arg Tyr Pro Lys Pro Thr Glu Pro Arg Leu Gly 
            340                 345                 350         


Ala Arg Glu Thr Pro Met Asp Thr Tyr Leu Glu Arg Glu Trp Gly Ser 
        355                 360                 365             


Lys Pro Ser Asp Cys Ala Pro Tyr Lys Glu Asp Glu Leu Tyr Gly Ile 
    370                 375                 380                 


Pro Ala Ser Cys Thr Pro Leu Ser Leu Ser Cys Leu Gln Leu Asn Thr 
385                 390                 395                 400 


Pro Glu Asn Arg Glu Asn Pro Val Ile Lys Ala Gly Ser Ser Lys Lys 
                405                 410                 415     


His Ala Asn His Leu Arg Lys Leu Val Phe Asp Asp Phe Cys Asp Ser 
            420                 425                 430         


Pro Asn Ala Cys Asn Asn Asn Ser Ser Glu Asp Asp Arg Arg Glu Asn 
        435                 440                 445             


Glu Lys Lys Ser Asp Cys Phe Ala Ser Ser Lys Thr Gly Phe Trp Asp 
    450                 455                 460                 


Cys Cys Ser Thr Ser Tyr Ala Gln Ser Leu Glu Phe Asp Gly Ser Glu 
465                 470                 475                 480 


Gly Asn Ala Ile Ala Asn Ser Val Gly Glu Ile Pro Ser Lys Leu Ser 
                485                 490                 495     


Glu Lys Ser Gly Ser Cys Leu Ser Lys Arg Leu Ser Cys Ile Arg Ser 
            500                 505                 510         


Leu Glu Met Asn Arg Thr Arg Thr Ser Ser Glu Ala Ser Met Asp Ala 
        515                 520                 525             


Ala Tyr Leu Asp Lys Ile Ser Glu Leu Asp Ser Met Met Ser Glu Ser 
    530                 535                 540                 


Asp Asn Ser Lys Ser Pro Cys Asn Asn Gly Phe Lys Ser Val Glu Val 
545                 550                 555                 560 


Glu Gly Pro Ser Lys Ser Pro Gln Gly Arg Glu Phe Leu Glu Glu Pro 
                565                 570                 575     


Asp Lys Leu Gln Glu Gly Ser Lys Leu Asn Leu Ser Lys Pro Ala Leu 
            580                 585                 590         


Thr Ala Asp Gly Leu Glu Ser Gly Gly Glu Trp Lys Pro Ser Ser Phe 
        595                 600                 605             


Phe Leu Leu Ser Pro Ala Asp His Glu Met Ser Glu Asp Phe Ser Leu 
    610                 615                 620                 


His Ser Thr Ser His Ser Gly Thr Ser Glu Val Lys Pro Pro Asn Cys 
625                 630                 635                 640 


Leu Phe Gln Thr Glu Phe Ser Gln Gly Ala Leu Leu Ser Ser Ser Gln 
                645                 650                 655     


Gly Leu Phe Glu Asp Gln Arg Phe Gly Ser Ser Leu Phe Lys Met Ser 
            660                 665                 670         


Ser Glu Met Gln Ser Leu His Ser Pro Leu Gln Ser Pro Trp Ser Ala 
        675                 680                 685             


Ala Phe Val Pro Glu Lys Arg Ser Lys Asn Gly Asn Gln Ser Thr Lys 
    690                 695                 700                 


Arg Lys Ile Gln Ser Ser Leu Ala Asn Ala Ser Pro Ser Lys Ala Thr 
705                 710                 715                 720 


Lys Ser 
        


<210>  24
<211>  659
<212>  PRT
<213>  Xenopus laevis

<400>  24

Met Ala Gln Thr Val Gln Asn Val Thr Leu Ser Leu Thr Leu Pro Ile 
1               5                   10                  15      


Thr Cys His Ile Cys Leu Gly Lys Val Arg Gln Pro Val Ile Cys Val 
            20                  25                  30          


Asn His His Val Phe Cys Thr Val Cys Ile Glu Leu Trp Leu Lys Asn 
        35                  40                  45              


Asn Asn Gln Cys Pro Val Cys Arg Val Pro Ile Thr Ala Glu Asn Pro 
    50                  55                  60                  


Cys Lys Asp Ile Ile Gly Gly Thr Gly Glu Asn Glu Cys Ala Leu Asp 
65                  70                  75                  80  


His Ser Val Arg Lys His Leu Arg Lys Thr Arg Leu Glu Leu Leu His 
                85                  90                  95      


Asn Glu Tyr Glu Glu Glu Ile Glu Ser Leu Leu Lys Glu Arg Glu Glu 
            100                 105                 110         


Leu Lys Gln Lys Asn Val Thr Leu Glu Lys Glu Arg Ser Pro Thr Thr 
        115                 120                 125             


Thr Val Ser Leu Gly His Asp Cys Asn Cys Gly Thr Lys Gln Gly Thr 
    130                 135                 140                 


Glu Asn Thr Ser Ser Glu Gln Ser Thr Ser Glu Lys Trp Lys Lys Lys 
145                 150                 155                 160 


Leu Glu Glu Thr Asn Ala Ala Ser Arg Lys Leu Val Ala Asp Val Glu 
                165                 170                 175     


Lys Leu Lys Glu Glu Asn Thr Lys Leu Ile Asn Glu Asn Ile Asp Tyr 
            180                 185                 190         


Val Arg Glu Asn Phe Arg Leu Lys Thr Glu Val Asp Ser Arg Ser Pro 
        195                 200                 205             


Gln Lys Phe Gly Arg Phe Thr Val Ala Ala Leu His Ala Lys Ile Asp 
    210                 215                 220                 


Gln Tyr Glu Lys Glu Met Asn Arg Leu Lys Lys Ala Leu Glu Arg Ser 
225                 230                 235                 240 


Asp Lys Tyr Ile Glu Glu Leu Glu Val Gln Val Asp Gln Leu Lys Arg 
                245                 250                 255     


Pro Ala Asp Trp Lys Pro Asn Glu Arg Ser His Asn Glu Asn Pro Val 
            260                 265                 270         


Arg Asp Lys Glu Thr Val Asn Ser Glu Ile Gly Asp Ser Ser Leu Asn 
        275                 280                 285             


Tyr Glu Gly Val Lys Leu Glu Gln Met Asp Lys Ile Pro Glu Lys Ala 
    290                 295                 300                 


Glu Lys Asn Gln Glu Asp Ser Asn Ser Thr Cys Pro Thr Ala Asn Asn 
305                 310                 315                 320 


His Lys Phe Ile Val Asn Lys Ser Glu Tyr Leu Ser Arg Thr Gly Cys 
                325                 330                 335     


Ser Met Asp Phe Gln Lys Asp Arg Lys Ser Phe Pro Ser Ser Ser Ser 
            340                 345                 350         


Ala Thr Trp Lys Glu Ser Leu Lys Ser Pro His Gly Lys Asn Ser Ser 
        355                 360                 365             


Arg Asn Lys Pro Arg Glu Ser Asn Thr Pro Cys Lys Glu Lys Glu Ile 
    370                 375                 380                 


His Glu Phe Ser Ser Pro Gly Thr Ser Leu Ser Phe Ser Ser Leu Gln 
385                 390                 395                 400 


Leu Asn Ser Pro Asp Cys Lys Phe Thr Leu Pro Ser Asn Gln Val Asn 
                405                 410                 415     


Ala Lys Lys Pro Leu Thr His Leu Arg Lys Leu Val Phe Asp Asp Ser 
            420                 425                 430         


Pro Lys Lys Arg Lys Pro Asn Gly Phe Ser Asn Ala Asn Asn Asn Gly 
        435                 440                 445             


Gly Leu Ser Lys Pro Phe Asn Glu Pro Lys Ser Glu Tyr Trp Ala Cys 
    450                 455                 460                 


Glu Val Lys His Lys His Ser Arg Asp Lys Leu Lys Glu Ser Tyr Val 
465                 470                 475                 480 


Gln Leu Glu Ser Leu Lys Asn Lys Glu Gly Gln Ile Leu Gln Ala Leu 
                485                 490                 495     


Pro Ser Leu Ser Ser Glu Glu Gly Asn Arg Thr Thr Thr Thr Ser Glu 
            500                 505                 510         


Ser Ser Met Asp Ile Thr Phe Leu Asp Val Asn Lys Leu Asp Ser Met 
        515                 520                 525             


Met Ser Thr Leu Glu Gly Asn Glu Asn Pro His Tyr His Ser Val Lys 
    530                 535                 540                 


Ser Asp Ala Val Met His Ser Asn Ser Gln Pro Arg Asn Gly Leu Gln 
545                 550                 555                 560 


Ala Leu Tyr Ser Asn Pro His Ser Gln Cys Ala Gly Gly Leu Leu Ser 
                565                 570                 575     


His Glu Ser Arg Ser Ser Asp Lys Ser His Asn Asn Asp Phe His Thr 
            580                 585                 590         


Ser Arg Ser Thr Ser Ser Leu Leu Thr Pro Phe Tyr Ala Thr Ala Gln 
        595                 600                 605             


Ser Tyr Ser Ser Lys Asn Leu Met Asp Leu Met Ala Pro Glu Met Thr 
    610                 615                 620                 


Ser Asn Ser Gly Ser Thr Ser Tyr Thr Asp Asn Lys Asn Gly Leu Thr 
625                 630                 635                 640 


Ser Lys Arg Lys Leu Phe Asn Pro Ile Cys Asp Ser Pro Pro Lys Ser 
                645                 650                 655     


Phe Lys Pro 
            


<210>  25
<211>  717
<212>  PRT
<213>  Felis catus

<400>  25

Met Ala Gln Thr Val Gln Asn Val Thr Leu Ser Leu Thr Leu Pro Ile 
1               5                   10                  15      


Thr Cys His Ile Cys Leu Gly Lys Val Arg Gln Pro Val Ile Cys Ile 
            20                  25                  30          


Asn Asn His Val Phe Cys Ser Ile Cys Ile Asp Leu Trp Leu Lys Asn 
        35                  40                  45              


Asn Ser Gln Cys Pro Ala Cys Arg Val Pro Ile Thr Pro Glu Asn Pro 
    50                  55                  60                  


Cys Lys Glu Ile Ile Gly Gly Thr Ser Glu Ser Glu Pro Met Leu Ser 
65                  70                  75                  80  


His Thr Val Arg Lys His Leu Arg Lys Thr Arg Leu Glu Leu Leu His 
                85                  90                  95      


Lys Glu Tyr Glu Asp Glu Ile Asp Cys Leu Gln Lys Glu Val Glu Asp 
            100                 105                 110         


Leu Lys Ser Lys Asn Leu Ser Leu Glu Ser Gln Ile Lys Thr Ile Leu 
        115                 120                 125             


Asp Pro Leu Thr Leu Met Gln Ser Ser Gln Thr Glu Asp Lys His Pro 
    130                 135                 140                 


Ile Ala Asp Asn Pro Ser Lys Ile Asp Pro Glu Thr Val Ala Glu Trp 
145                 150                 155                 160 


Lys Lys Lys Leu Arg Thr Ala Asn Glu Ile Tyr Glu Lys Val Lys Asp 
                165                 170                 175     


Asp Val Asp Lys Leu Lys Glu Ala Asn Lys Lys Leu Lys Leu Glu Asn 
            180                 185                 190         


Gly Gly Leu Val Arg Glu Asn Leu Arg Leu Lys Ala Glu Val Asp Asn 
        195                 200                 205             


Arg Ser Pro Gln Lys Phe Gly Arg Phe Thr Val Ala Ala Leu Gln Ser 
    210                 215                 220                 


Lys Val Glu Gln His Glu Arg Glu Thr Asn Arg Leu Lys Lys Ala Leu 
225                 230                 235                 240 


Glu Arg Ser Asp Lys Tyr Ile Glu Glu Leu Glu Ser Gln Ile Ala Gln 
                245                 250                 255     


Leu Lys Asn Ser Ser Glu Glu Lys Glu Ala Ile Asn Ser Ile Cys Gln 
            260                 265                 270         


Arg Ala Leu Ser Thr Asp Gly Lys Gly Ser Leu Gly Gly Glu Glu Asp 
        275                 280                 285             


Met Ala Ser Lys Asn Gln Gly Asp Gly Ala Arg Lys Gln Leu Gly Ser 
    290                 295                 300                 


Ser Thr Ser Ser Ser His Leu Pro Lys Pro Ser Ser Ser Ser Ala Arg 
305                 310                 315                 320 


Gln Glu Ser Thr Ser Lys Thr Glu Pro Asn Cys Ser Lys Asn Lys Asp 
                325                 330                 335     


Leu Tyr Gln Lys Arg Val Glu Ile Met Leu Asp Val Thr Asp Thr Ser 
            340                 345                 350         


Met Asp Thr Tyr Leu Glu Arg Glu Trp Gly Asn Lys Pro Ser Asp Cys 
        355                 360                 365             


Ile Pro Tyr Lys Asp Glu Glu Leu Tyr Asp Leu Pro Ala Pro Cys Thr 
    370                 375                 380                 


Pro Leu Ser Leu Ser Cys Leu Gln Leu Ser Thr Pro Glu Asn Arg Glu 
385                 390                 395                 400 


Ser Ser Val Val Lys Ala Val Gly Ser Lys Lys His Ser Asn His Leu 
                405                 410                 415     


Arg Lys Leu Val Phe Asp Asp Phe Cys Asp Ser Ser Asn Val Cys Thr 
            420                 425                 430         


Lys Asp Ser Ser Glu Asp Asp Arg Ser Glu Asn Glu Lys Lys Ser Glu 
        435                 440                 445             


Cys Phe Thr Ser Ser Lys Thr Gly Phe Trp Asp Cys Cys Ser Thr Ser 
    450                 455                 460                 


Tyr Ala Gln Ser Leu Asp Phe Glu Ser Ser Glu Gly Asn Thr Ile Ala 
465                 470                 475                 480 


Asn Ser Val Gly Glu Ile Ser Leu Lys Leu Ser Glu Lys Ser Gly Ser 
                485                 490                 495     


Cys Ile Ser Lys Arg Leu Asn Ser Ile Arg Cys Phe Glu Met Asn Arg 
            500                 505                 510         


Thr Arg Thr Ser Ser Glu Ala Ser Met Asp Ala Ala Tyr Leu Asp Lys 
        515                 520                 525             


Ile Ser Glu Leu Asp Ser Met Met Ser Glu Ser Asp Asn Ser Lys Ser 
    530                 535                 540                 


Pro Cys Asn Asn Gly Phe Lys Ser Val Asp Leu Asp Gly Leu Ser Lys 
545                 550                 555                 560 


Ser Ser Gln Gly Ser Glu Phe Leu Glu Glu Pro Asp Lys Leu Asp Glu 
                565                 570                 575     


Arg Thr Lys Pro Asn Leu Ser Lys Gly Ser Leu Thr Thr Asp Gln Leu 
            580                 585                 590         


Glu Asn Gly Asn Glu Trp Lys Pro Thr Ser Phe Phe Leu Leu Ser Pro 
        595                 600                 605             


Ser Asp Gln Glu Met Asn Glu Asp Phe Ser Leu His Thr Ser Ser Asn 
    610                 615                 620                 


Pro Gly Thr Asn Glu Ile Lys Pro Pro Ser Cys Leu Phe Gln Thr Glu 
625                 630                 635                 640 


Phe Ser Gln Gly Val Leu Leu Ser Ser Ser His Arg Leu Phe Glu Asp 
                645                 650                 655     


Gln Arg Phe Gly Ser Ser Leu Phe Lys Met Thr Ser Glu Met His Gly 
            660                 665                 670         


Leu His Asn His Leu Gln Ser Pro Trp Ser Thr Ser Phe Val Pro Glu 
        675                 680                 685             


Lys Arg Asn Lys Asn Ile Thr Gln Ser Thr Lys Arg Lys Ile Gln Ser 
    690                 695                 700                 


Ser Leu Ser Asn Ala Ser Pro Ser Lys Ala Thr Lys Ser 
705                 710                 715         


<210>  26
<211>  724
<212>  PRT
<213>  Rattus norvegicus

<400>  26

Met Ala Gln Thr Val Gln Asn Val Thr Leu Ser Leu Thr Leu Pro Ile 
1               5                   10                  15      


Thr Cys His Ile Cys Leu Gly Lys Val Arg Gln Pro Val Val Cys Thr 
            20                  25                  30          


Asn Asn His Val Phe Cys Ser Ile Cys Ile Asp Leu Trp Leu Lys Asn 
        35                  40                  45              


Asn Ser Gln Cys Pro Ala Cys Arg Val Pro Ile Thr Thr Glu Asn Pro 
    50                  55                  60                  


Cys Lys Glu Ile Ile Gly Gly Thr Ser Glu Ser Glu Pro Met Leu Ser 
65                  70                  75                  80  


His Thr Val Arg Arg His Leu Arg Arg Thr Arg Leu Glu Leu Leu His 
                85                  90                  95      


Arg Glu Tyr Glu Asp Glu Ile Asp Cys Leu Gln Lys Glu Val Glu Glu 
            100                 105                 110         


Leu Lys Ser Lys Asn Leu Ser Leu Glu Ser Gln Ile Lys Thr Ile Leu 
        115                 120                 125             


Asp Pro Leu Ala Leu Met Gln Gly Ser Gln Asn Glu Asp Lys His Pro 
    130                 135                 140                 


Met Ala Asp Asn Pro Ser Lys Ile Asp Pro Glu Ser Val Val Glu Trp 
145                 150                 155                 160 


Lys Lys Lys Leu Arg Thr Ala Asn Glu Ile Tyr Glu Lys Val Lys Asp 
                165                 170                 175     


Asp Val Asp Lys Leu Lys Glu Ala Asn Lys Lys Leu Lys Leu Glu Asn 
            180                 185                 190         


Gly Gly Leu Leu Arg Glu Asn Leu Arg Leu Lys Ala Glu Val Asp Asn 
        195                 200                 205             


Arg Ser Pro Gln Lys Phe Gly Arg Phe Thr Val Ala Ala Leu Gln Ser 
    210                 215                 220                 


Lys Val Glu Gln Tyr Glu Arg Glu Thr Asn Arg Leu Lys Lys Ala Leu 
225                 230                 235                 240 


Glu Arg Ser Asp Lys Tyr Ile Glu Glu Leu Glu Ser Gln Val Ala Gln 
                245                 250                 255     


Leu Arg His Ser Glu Glu Thr Glu Glu Gly Met Gly Ala Leu Cys Gln 
            260                 265                 270         


Arg Ala Pro Ser Ala Asp Gly Lys Gly Pro Lys Gly Ser Asp Asp Val 
        275                 280                 285             


Ala Ala Ser Lys Asn Pro Ser Glu Gly Ala Gly Lys Gln Ala Gly Ser 
    290                 295                 300                 


Ala Asn Ser Ala Ser His Leu Ala Thr Pro Ser Ser Ser Arg Leu Ala 
305                 310                 315                 320 


Asp Thr Ser Ser Ala Arg Gln Glu Ser Thr Ser Arg Thr Glu Pro Asn 
                325                 330                 335     


Cys Leu Gln Asn Lys Asp Arg Tyr Pro Lys Pro Thr Glu Ala Gln Leu 
            340                 345                 350         


Gly Ala Arg Glu Thr Pro Met Asp Thr Tyr Leu Glu Arg Gln Trp Gly 
        355                 360                 365             


Ser Lys Pro Ser Asp Cys Ala Pro Tyr Lys Glu Glu Glu Leu Tyr Gly 
    370                 375                 380                 


Leu Gln Ala Ser Cys Thr Pro Leu Ser Leu Ser Cys Leu Gln Leu Asn 
385                 390                 395                 400 


Thr Pro Glu Asn Arg Glu Asn Pro Val Ile Lys Ala Gly Gly Ser Lys 
                405                 410                 415     


Lys His Ala Asn His Leu Arg Lys Leu Val Phe Asp Asp Phe Cys Asp 
            420                 425                 430         


Ser Pro Asn Thr Cys Asn Asn Asn Ser Ser Glu Asp Asp Arg Ser Gly 
        435                 440                 445             


Asn Glu Lys Lys Ser Asp Cys Phe Ala Ser Ser Lys Thr Glu Phe Trp 
    450                 455                 460                 


Asp Cys Cys Ser Thr Ser Tyr Ala Gln Ser Leu Glu Phe Asp Gly Ser 
465                 470                 475                 480 


Glu Gly Asn Thr Ile Ala Asn Pro Val Gly Glu Val Pro Ser Lys Leu 
                485                 490                 495     


Ser Glu Lys Ser Gly Phe Cys Leu Ser Lys Arg Leu Ser Cys Ile Arg 
            500                 505                 510         


Ser Leu Glu Met Asn Arg Thr Arg Thr Ser Ser Glu Ala Ser Met Asp 
        515                 520                 525             


Ala Ala Tyr Leu Asp Lys Ile Ser Glu Leu Asp Ser Met Met Ser Glu 
    530                 535                 540                 


Ser Asp Asn Ser Lys Ser Pro Cys Asn Asn Gly Phe Lys Ser Val Glu 
545                 550                 555                 560 


Ser Glu Gly Ser Ser Lys Ser Pro Gln Gly Arg Glu Phe Leu Glu Glu 
                565                 570                 575     


Pro Asp Lys Leu Gln Glu Gly Ala Lys Leu Ser Leu Pro Lys Asn Ala 
            580                 585                 590         


Leu Glu Ala Asp Gly Leu Glu Gly Gly Ser Glu Trp Lys Pro Ser Ser 
        595                 600                 605             


Phe Phe Leu Leu Ser Pro Ser Asp His Glu Met Ser Glu Asp Phe Ser 
    610                 615                 620                 


Leu His Thr Thr Ser His Ser Gly Ala Ser Glu Val Lys Ser Gln Asn 
625                 630                 635                 640 


Cys Leu Phe Gln Thr Glu Phe Ser Gln Gly Val Gln Leu Leu Ser Ser 
                645                 650                 655     


Ser Gln Gly Leu Phe Glu Asp Gln Arg Phe Gly Ser Ser Leu Phe Lys 
            660                 665                 670         


Met Ser Ser Asp Met Gln Ser Leu Pro Gly Pro Leu Gln Ser Pro Trp 
        675                 680                 685             


Ser Ala Ala Phe Val Ser Glu Lys Arg Ser Lys Asn Gly Asn Gln Ser 
    690                 695                 700                 


Ala Lys Arg Lys Ile Gln Ser Ser Leu Ser Asn Ala Ser Pro Ser Lys 
705                 710                 715                 720 


Ala Thr Lys Ser 
                


<210>  27
<211>  654
<212>  PRT
<213>  Xenopus tropicalis

<400>  27

Met Ala Gln Asn Val Gln Asn Val Thr Leu Ser Leu Thr Leu Pro Ile 
1               5                   10                  15      


Thr Cys His Ile Cys Leu Gly Lys Val Arg Gln Pro Val Ile Cys Val 
            20                  25                  30          


Asn Tyr His Val Phe Cys Thr Val Cys Ile Glu Leu Trp Leu Lys Asn 
        35                  40                  45              


Asn Ser Gln Cys Pro Val Cys Arg Val Pro Ile Thr Ala Glu Asn Pro 
    50                  55                  60                  


Cys Lys Asp Ile Ile Gly Gly Thr Gly Glu Asn Glu Cys Ser Leu Asp 
65                  70                  75                  80  


His Ser Val Arg Lys His Leu Arg Lys Thr Arg Leu Glu Leu Leu His 
                85                  90                  95      


Asn Glu Tyr Glu Glu Glu Ile Glu Ser Leu Leu Lys Glu Leu Glu Glu 
            100                 105                 110         


Leu Lys Gln Lys Asn Ile Ile Leu Glu Arg Glu Arg Ser Pro Thr Thr 
        115                 120                 125             


Thr Val Ser Leu Gly Ile Asp Cys Asn Cys Gly Thr Lys Leu Arg Thr 
    130                 135                 140                 


Glu Asn Thr Ser Ser Glu Gln Thr Thr Ser Glu Lys Trp Lys Lys Lys 
145                 150                 155                 160 


Leu Glu Glu Thr Asn Ala Ala Ser Arg Lys Leu Ser Ala Asp Val Glu 
                165                 170                 175     


Lys Leu Lys Glu Glu Asn Ala Lys Leu Ile Asn Glu Asn Ile Asp Tyr 
            180                 185                 190         


Val Arg Glu Asn Phe Arg Leu Lys Thr Glu Val Asp Ser Arg Ser Pro 
        195                 200                 205             


Gln Lys Phe Gly Arg Phe Thr Val Ala Ala Leu His Ala Lys Ile Asp 
    210                 215                 220                 


Gln Tyr Glu Lys Glu Met Asn Arg Leu Lys Lys Ala Leu Glu Arg Ser 
225                 230                 235                 240 


Asp Lys Tyr Ile Glu Glu Leu Glu Val Gln Val Asp Gln Leu Lys Arg 
                245                 250                 255     


Ala Ala Asp Leu Lys Gln Asp Glu Ser Ser Gln Asn Glu Asn Ser Val 
            260                 265                 270         


His Asp Lys Asp Thr Val Asn Ser Glu Ile Gly Cys Thr Glu Leu Tyr 
        275                 280                 285             


Glu Gly Val Lys Leu Glu Gln Met Gly Glu Lys Pro Glu Lys His Asp 
    290                 295                 300                 


Ile Asn Lys Glu Asn Ser Ser Asp Thr Cys Pro Ala Ala Asn Asn Glu 
305                 310                 315                 320 


Lys Ser His Val His Arg Ser Glu Tyr Leu Thr Gln Thr Gly Cys Ser 
                325                 330                 335     


Leu Asn Phe Gln Lys Glu Arg Lys Met Phe Leu Ser Ser Gly Ser Ala 
            340                 345                 350         


Met Trp Lys Glu Ser Met Lys Gly Pro His Asp Asn Ile Thr Ser Gln 
        355                 360                 365             


Asn Lys Gln Thr Glu Thr Tyr Thr Pro Thr Lys Glu Lys Glu Ile His 
    370                 375                 380                 


Glu Tyr Asn Ser Pro Ser Thr Ser Leu Ser Phe Ser Ser Leu Gln Leu 
385                 390                 395                 400 


Asn Ser Pro Asp Cys Lys Leu Ser Leu Pro Ser Asn Gln Val Asn Ala 
                405                 410                 415     


Lys Lys Pro Leu Thr Tyr Leu Arg Lys Leu Val Phe Glu Asp Tyr Pro 
            420                 425                 430         


Lys Lys Gly Lys Pro Asn Ser Phe Ser Ser Ala Asn Asn Asn Ile Pro 
        435                 440                 445             


Lys Pro Phe Asn Glu Gln Lys Ser Glu Tyr Met Thr Cys Glu Val Lys 
    450                 455                 460                 


His Lys His Gln Arg Gly Asn Leu Lys Glu Ser Asp Met Gln Ser Glu 
465                 470                 475                 480 


Gly Gln Ile Leu Gln Ala Phe Ser Leu Pro Ser Ser Gly Glu Val His 
                485                 490                 495     


His Thr Thr Thr Thr Ser Glu Ser Pro Met Asp Thr Phe Leu His Asn 
            500                 505                 510         


Val Asn Asn Leu Asp Ser Leu Met Ser Thr Leu Glu Gly Asn Lys Ser 
        515                 520                 525             


Leu His Tyr His Ser Val Thr Ala Asp Ala Val Met His Leu Asn Ser 
    530                 535                 540                 


Gln Pro Gly Asn Gly Leu Gln Ala Phe Phe Ser Asn Pro His Thr Arg 
545                 550                 555                 560 


Asp Gly His Phe Pro Leu Glu Ser Gln Ser Ser Asp Lys Ser His Ile 
                565                 570                 575     


Asn Asp Phe His Thr Ser Gly Arg Thr Ser Ser Leu Val Leu Pro Phe 
            580                 585                 590         


Asn Asp Met Pro Gln Ile Lys Tyr Gln Asn Thr Thr Glu Ser Ser Asn 
        595                 600                 605             


Ile Leu Thr Asn Leu Asn Ala Ser Glu Leu Ala Ser Asn Ser Cys Cys 
    610                 615                 620                 


Thr Ser Tyr Thr Asn Asn Lys His Gly Pro Ala Ser Lys Arg Lys Leu 
625                 630                 635                 640 


Leu Asn Thr Ile Cys Glu Ser Pro Pro Lys Thr Met Lys Pro 
                645                 650                 


<210>  28
<211>  39
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  ring finger - zinc finger of OBI1 proteins


<220>
<221>  misc_feature
<222>  (13)..(13)
<223>  Xaa can be any naturally occurring amino acid

<220>
<221>  misc_feature
<222>  (15)..(15)
<223>  Xaa can be any naturally occurring amino acid

<220>
<221>  misc_feature
<222>  (23)..(23)
<223>  Xaa can be any naturally occurring amino acid

<400>  28

Cys His Ile Cys Leu Gly Lys Val Arg Gln Pro Val Xaa Cys Xaa Asn 
1               5                   10                  15      


Asn His Val Phe Cys Ser Xaa Cys Ile Asp Leu Trp Leu Lys Asn Asn 
            20                  25                  30          


Ser Gln Cys Pro Ala Cys Arg 
        35                  


<210>  29
<211>  194
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Coiled-Coil domain of huaman Obi1

<400>  29

Val Arg Lys His Leu Arg Lys Thr Arg Leu Glu Leu Leu His Lys Glu 
1               5                   10                  15      


Tyr Glu Asp Glu Ile Asp Cys Leu Gln Lys Glu Val Glu Glu Leu Lys 
            20                  25                  30          


Ser Lys Asn Leu Ser Leu Glu Ser Gln Ile Lys Thr Ile Leu Asp Pro 
        35                  40                  45              


Leu Thr Leu Val Gln Gly Asn Gln Asn Glu Asp Lys His Leu Val Thr 
    50                  55                  60                  


Asp Asn Pro Ser Lys Ile Asn Pro Glu Thr Val Ala Glu Trp Lys Lys 
65                  70                  75                  80  


Lys Leu Arg Thr Ala Asn Glu Ile Tyr Glu Lys Val Lys Asp Asp Val 
                85                  90                  95      


Asp Lys Leu Lys Glu Ala Asn Lys Lys Leu Lys Leu Glu Asn Gly Gly 
            100                 105                 110         


Leu Val Arg Glu Asn Leu Arg Leu Lys Ala Glu Val Asp Asn Arg Ser 
        115                 120                 125             


Pro Gln Lys Phe Gly Arg Phe Ala Val Ala Ala Leu Gln Ser Lys Val 
    130                 135                 140                 


Glu Gln Tyr Glu Arg Glu Thr Asn Arg Leu Lys Lys Ala Leu Glu Arg 
145                 150                 155                 160 


Ser Asp Lys Tyr Ile Glu Glu Leu Glu Ser Gln Val Ala Gln Leu Lys 
                165                 170                 175     


Asn Ser Ser Glu Glu Lys Glu Ala Met Asn Ser Ile Cys Gln Thr Ala 
            180                 185                 190         


Leu Ser 
        


<210>  30
<211>  450
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  C-terminal part of human Obi1

<400>  30

Ala Asp Gly Lys Gly Ser Lys Gly Ser Glu Glu Asp Val Val Ser Lys 
1               5                   10                  15      


Asn Gln Gly Asp Ser Ala Arg Lys Gln Pro Gly Ser Ser Thr Ser Ser 
            20                  25                  30          


Ser Ser His Leu Ala Lys Pro Ser Ser Ser Arg Leu Cys Asp Thr Ser 
        35                  40                  45              


Ser Ala Arg Gln Glu Ser Thr Ser Lys Ala Asp Leu Asn Cys Ser Lys 
    50                  55                  60                  


Asn Lys Asp Leu Tyr Gln Glu Gln Val Glu Val Met Leu Asp Val Thr 
65                  70                  75                  80  


Asp Thr Ser Met Asp Thr Tyr Leu Glu Arg Glu Trp Gly Asn Lys Pro 
                85                  90                  95      


Ser Asp Cys Val Pro Tyr Lys Asp Glu Glu Leu Tyr Asp Leu Pro Ala 
            100                 105                 110         


Pro Cys Thr Pro Leu Ser Leu Ser Cys Leu Gln Leu Ser Thr Pro Glu 
        115                 120                 125             


Asn Arg Glu Ser Ser Val Val Gln Ala Gly Gly Ser Lys Lys His Ser 
    130                 135                 140                 


Asn His Leu Arg Lys Leu Val Phe Asp Asp Phe Cys Asp Ser Ser Asn 
145                 150                 155                 160 


Val Ser Asn Lys Asp Ser Ser Glu Asp Asp Ile Ser Arg Ser Glu Asn 
                165                 170                 175     


Glu Lys Lys Ser Glu Cys Phe Ser Ser Pro Lys Thr Gly Phe Trp Asp 
            180                 185                 190         


Cys Cys Ser Thr Ser Tyr Ala Gln Asn Leu Asp Phe Glu Ser Ser Glu 
        195                 200                 205             


Gly Asn Thr Ile Ala Asn Ser Val Gly Glu Ile Ser Ser Lys Leu Ser 
    210                 215                 220                 


Glu Lys Ser Gly Leu Cys Leu Ser Lys Arg Leu Asn Ser Ile Arg Ser 
225                 230                 235                 240 


Phe Glu Met Asn Arg Thr Arg Thr Ser Ser Glu Ala Ser Met Asp Ala 
                245                 250                 255     


Ala Tyr Leu Asp Lys Ile Ser Glu Leu Asp Ser Met Met Ser Glu Ser 
            260                 265                 270         


Asp Asn Ser Lys Ser Pro Cys Asn Asn Gly Phe Lys Ser Leu Asp Leu 
        275                 280                 285             


Asp Gly Leu Ser Lys Ser Ser Gln Gly Ser Glu Phe Leu Glu Glu Pro 
    290                 295                 300                 


Asp Lys Leu Glu Glu Lys Thr Glu Leu Asn Leu Ser Lys Gly Ser Leu 
305                 310                 315                 320 


Thr Asn Asp Gln Leu Glu Asn Gly Ser Glu Trp Lys Pro Thr Ser Phe 
                325                 330                 335     


Phe Leu Leu Ser Pro Ser Asp Gln Glu Met Asn Glu Asp Phe Ser Leu 
            340                 345                 350         


His Ser Ser Ser Cys Pro Val Thr Asn Glu Ile Lys Pro Pro Ser Cys 
        355                 360                 365             


Leu Phe Gln Thr Glu Phe Ser Gln Gly Ile Leu Leu Ser Ser Ser His 
    370                 375                 380                 


Arg Leu Phe Glu Asp Gln Arg Phe Gly Ser Ser Leu Phe Lys Met Ser 
385                 390                 395                 400 


Ser Glu Met His Ser Leu His Asn His Leu Gln Ser Pro Trp Ser Thr 
                405                 410                 415     


Ser Phe Val Pro Glu Lys Arg Asn Lys Asn Val Asn Gln Ser Thr Lys 
            420                 425                 430         


Arg Lys Ile Gln Ser Ser Leu Ser Ser Ala Ser Pro Ser Lys Ala Thr 
        435                 440                 445             


Lys Ser 
    450 


<210>  31
<211>  3552
<212>  DNA
<213>  Homo sapiens

<400>  31
ggcgaagagt agcggtaggt cggcgggact tccgtgttgg cgggattctg aacgctgcca       60

tggctcagac cgtgcagaat gttacattgt cgctcactct gcccatcacg tgccacattt      120

gcttggggaa ggtacgtcag cctgtcatat gcatcaacaa ccatgtattt tgttcgattt      180

gtattgattt gtggttgaag aataatagcc agtgtccagc ttgcagagtc cccatcactc      240

ctgaaaatcc ttgcaaagaa attataggag gaacaagtga aagtgaacct atgctaagcc      300

atacggtcag gaagcatctt cggaaaacta gacttgaatt actacacaaa gaatatgagg      360

acgaaataga ttgtttacag aaagaagtag aagagcttaa gagtaaaaat ctcagcttgg      420

agtcacagat caaaactatt ctggatcctt taaccttggt gcagggcaac caaaatgaag      480

acaaacatct agtcacagat aatccaagta aaattaaccc agaaactgta gcagagtgga      540

agaaaaaact cagaacagct aatgaaatct atgaaaaagt gaaagatgat gtggataagc      600

taaaggaggc aaataaaaaa ttgaaattgg aaaatggtgg tctggtgagg gagaatttac      660

gactgaaggc tgaagttgat aacagatcac ctcaaaagtt tggaaggttt gcagttgctg      720

ctcttcagtc caaagtagaa cagtatgagc gtgaaaccaa tcgcctcaag aaagccctgg      780

aacgaagtga taagtatata gaggaactag aatctcaagt tgcacagcta aaaaattcaa      840

gtgaagagaa agaagctatg aattccattt gccagacagc actttctgca gatggcaaag      900

ggagcaaagg cagtgaggag gatgtggtgt caaagaatca aggcgatagt gccagaaagc      960

agcctggctc atccacctcc agttcttctc acctagcgaa gccttccagc agcagactgt     1020

gtgacaccag ttctgcaagg caggaaagta ccagcaaagc agaccttaac tgttctaaga     1080

acaaagacct atatcaagaa caggtagaag taatgttaga tgtgacagat acaagtatgg     1140

atacttattt ggaaagagaa tgggggaata aaccaagtga ctgtgtaccc tacaaagatg     1200

aagaacttta tgatcttcca gctccttgta ctcctttgtc ccttagttgc cttcagctca     1260

gtactccaga aaatagagag agctctgtgg tccaagcagg aggttccaaa aagcactcaa     1320

accatctcag aaaattggtg tttgatgatt tttgtgattc ttcaaatgtt tctaataaag     1380

attcttcaga agatgatata agtagaagtg aaaatgaaaa gaaatcagaa tgtttttctt     1440

ccccaaagac aggattttgg gactgttgtt ccacaagcta tgcccaaaac ttagattttg     1500

aaagttcaga ggggaacacg atagcaaatt ctgttggaga aatatcttca aaattgagtg     1560

agaaatcagg cttatgttta tccaaaaggt tgaattctat tcgctctttt gaaatgaacc     1620

ggacaagaac atccagtgaa gcatcgatgg atgctgctta ccttgacaaa atctctgagt     1680

tggattcaat gatgtcagag tcagacaaca gcaagagccc ttgtaataac ggttttaagt     1740

cactggattt ggatgggtta tcaaagtcat ctcaaggcag tgaatttctt gaggaacctg     1800

ataagttgga agaaaaaact gagctaaacc tttccaaagg ttctctaact aatgatcagt     1860

tagaaaatgg aagtgaatgg aaacccactt ctttttttct cctctctcca tctgaccaag     1920

aaatgaatga agatttttca ctccattcca gttcttgtcc agtaactaat gaaatcaaac     1980

ccccaagctg cttgtttcag acagagtttt cccagggcat tttgttaagc agttcacatc     2040

gactatttga agatcaaaga tttgggtcat ctttgtttaa gatgtcctca gagatgcaca     2100

gtcttcataa ccaccttcag tctccttggt ctacttcctt tgtgcctgaa aagaggaata     2160

aaaatgtgaa tcaatcaaca aaaagaaaaa tccagagcag cctttccagt gccagcccat     2220

caaaagcaac taaaagttga ctcattagaa aggtgtcatt tgtggttttg tcctgagaga     2280

aatagaaaag ttgttaaagt tacctttttt cctcataaaa gttctataca aattggaatt     2340

gataatcttt agtcaagtat caagtcagga tggtggatta acctgtaccc agaatactta     2400

ttgttcattt tgaaaagact ttgttctttt catttttatt tgggagtctt tgtgaccaga     2460

gaagttaggg aggaggttat ttttgtgttt tggggttggt tggttggttg gttttgtttt     2520

tggttttgtt tttttactga atttgatatg tatctcggtt ggatatacat tgttttttta     2580

aaaaatgtta tttaactgtt agatacagtg gcctgttgat aagccccact tgtcttcaga     2640

acttggattt cttaaataaa acttttagtg ttgtctatac actgctcaat aagacacttg     2700

agtttaagct tttcccaggg tggaaattat tttacctgtc cctttttatt tatgtttagt     2760

gatggcctag tttttctgca gggccatgat ggagaaatag cactctagcc ttagtccaat     2820

attgatttac tttctttttt taggttttat gtatatgttt gcatttttta gcattgtgtt     2880

ttgtccagtt ttgtgaaaat gttctgctag tatgaaagaa aacattttct atatgaagac     2940

atttgtttta tgttaggtag cttacatttt ctcctctgcg tgtgtgtgta tgtgtgtaaa     3000

atcagaaatt tagcatacta tggaaagaag gcatggagca cttgggttta gaggaaccta     3060

aaacatcata gcttcattgt tccagatgta acaggtttga aagagctcat cgccaagttc     3120

ttgatccact tgcattccag gggagttttc ttttgagtag tatgtttctt gtttgcatgt     3180

tcctgttctt tgtggaaact atgcatggta gcatttttgc ttgctgtgtt ttccatactt     3240

aagaaaaaga ggtttcagtt ggctgataga atatctttta tgtaggacaa aacttttctg     3300

tgaagagtgt tgagggggtg aagataggta agaggtaagc acaattttta atttaggctc     3360

tgaaaaagtg tattgttcta aacgtatttg gtatgcctat ataggtcttt aaaaatgggt     3420

atgtatgctg tttaatgtgc actgaacatt ttacattaat attgtactgt tttacattaa     3480

tactgcatgc ttttctatgt gaattgaata aagaatgtca taagcactgt gttcaaaaaa     3540

aaaaaaaaaa aa                                                         3552


<210>  32
<211>  19
<212>  DNA
<213>  Artificial sequence

<220>
<223>  siRNA inhibiting OBI1

<400>  32
gtagaagtaa tgttagatg                                                    19


<210>  33
<211>  19
<212>  DNA
<213>  Artificial sequence

<220>
<223>  siRNA inhibiting OBI1

<400>  33
ccaaaggttc tctaactaa                                                    19


<210>  34
<211>  19
<212>  DNA
<213>  Artificial sequence

<220>
<223>  siRNA inhibiting OBI1

<400>  34
ggatttggat gggttatca                                                    19


<210>  35
<211>  19
<212>  DNA
<213>  Artificial sequence

<220>
<223>  siRNA inhibiting OBI1

<400>  35
gaacgaagtg ataagtata                                                    19


<210>  36
<211>  19
<212>  RNA
<213>  Artificial sequence

<220>
<223>  siRNA inhibiting OBI1

<400>  36
guagaaguaa uguuagaug                                                    19


<210>  37
<211>  19
<212>  RNA
<213>  Artificial sequence

<220>
<223>  siRNA inhibiting OBI1

<400>  37
ccaaagguuc ucuaacuaa                                                    19


<210>  38
<211>  19
<212>  RNA
<213>  Artificial sequence

<220>
<223>  siRNA inhibiting OBI1

<400>  38
ggauuuggau ggguuauca                                                    19


<210>  39
<211>  19
<212>  RNA
<213>  Artificial sequence

<220>
<223>  siRNA inhibiting OBI1

<400>  39
gaacgaagug auaaguaua                                                    19


<210>  40
<211>  19
<212>  DNA
<213>  Artificial sequence

<220>
<223>  siRNA inhibiting OBI1

<400>  40
catctaacat tacttctac                                                    19


<210>  41
<211>  19
<212>  DNA
<213>  Artificial sequence

<220>
<223>  siRNA inhibiting OBI1

<400>  41
ttagttagag aacctttgg                                                    19


<210>  42
<211>  19
<212>  DNA
<213>  Artificial sequence

<220>
<223>  siRNA inhibiting OBI1

<400>  42
tgataaccca tccaaatcc                                                    19


<210>  43
<211>  19
<212>  DNA
<213>  Artificial sequence

<220>
<223>  siRNA inhibiting OBI1

<400>  43
tatacttatc acttcgttc                                                    19


<210>  44
<211>  19
<212>  RNA
<213>  Artificial sequence

<220>
<223>  siRNA inhibiting OBI1

<400>  44
caucuaacau uacuucuac                                                    19


<210>  45
<211>  19
<212>  RNA
<213>  Artificial sequence

<220>
<223>  siRNA inhibiting OBI1

<400>  45
uuaguuagag aaccuuugg                                                    19


<210>  46
<211>  19
<212>  RNA
<213>  Artificial sequence

<220>
<223>  siRNA inhibiting OBI1

<400>  46
ugauaaccca uccaaaucc                                                    19


<210>  47
<211>  19
<212>  RNA
<213>  Artificial sequence

<220>
<223>  siRNA inhibiting OBI1

<400>  47
uauacuuauc acuucguuc                                                    19


<210>  48
<211>  21
<212>  DNA
<213>  Artificial sequence

<220>
<223>  siRNA inhibiting OBI1

<400>  48
guagaaguaa uguuagaugt t                                                 21


<210>  49
<211>  21
<212>  DNA
<213>  Artificial sequence

<220>
<223>  siRNA inhibiting OBI1

<400>  49
ccaaagguuc ucuaacuaat t                                                 21


<210>  50
<211>  21
<212>  DNA
<213>  Artificial sequence

<220>
<223>  siRNA inhibiting OBI1

<400>  50
ggauuuggau ggguuaucat t                                                 21


<210>  51
<211>  21
<212>  DNA
<213>  Artificial sequence

<220>
<223>  siRNA inhibiting OBI1

<400>  51
gaacgaagug auaaguauat t                                                 21


<210>  52
<211>  21
<212>  DNA
<213>  Artificial sequence

<220>
<223>  siRNA inhibiting OBI1

<400>  52
caucuaacau uacuucuact t                                                 21


<210>  53
<211>  21
<212>  DNA
<213>  Artificial sequence

<220>
<223>  siRNA inhibiting OBI1

<400>  53
uuaguuagag aaccuuuggt t                                                 21


<210>  54
<211>  21
<212>  DNA
<213>  Artificial sequence

<220>
<223>  siRNA inhibiting OBI1

<400>  54
ugauaaccca uccaaaucct t                                                 21


<210>  55
<211>  21
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  siRNA inhibiting OBI1

<400>  55
uauacuuauc acuucguuct t                                                 21


<210>  56
<211>  10
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  shRNA loop

<400>  56
cuuccuguca                                                              10


<210>  57
<211>  861
<212>  PRT
<213>  Homo sapiens

<400>  57

Met Ala His Tyr Pro Thr Arg Leu Lys Thr Arg Lys Thr Tyr Ser Trp 
1               5                   10                  15      


Val Gly Arg Pro Leu Leu Asp Arg Lys Leu His Tyr Gln Thr Tyr Arg 
            20                  25                  30          


Glu Met Cys Val Lys Thr Glu Gly Cys Ser Thr Glu Ile His Ile Gln 
        35                  40                  45              


Ile Gly Gln Phe Val Leu Ile Glu Gly Asp Asp Asp Glu Asn Pro Tyr 
    50                  55                  60                  


Val Ala Lys Leu Leu Glu Leu Phe Glu Asp Asp Ser Asp Pro Pro Pro 
65                  70                  75                  80  


Lys Lys Arg Ala Arg Val Gln Trp Phe Val Arg Phe Cys Glu Val Pro 
                85                  90                  95      


Ala Cys Lys Arg His Leu Leu Gly Arg Lys Pro Gly Ala Gln Glu Ile 
            100                 105                 110         


Phe Trp Tyr Asp Tyr Pro Ala Cys Asp Ser Asn Ile Asn Ala Glu Thr 
        115                 120                 125             


Ile Ile Gly Leu Val Arg Val Ile Pro Leu Ala Pro Lys Asp Val Val 
    130                 135                 140                 


Pro Thr Asn Leu Lys Asn Glu Lys Thr Leu Phe Val Lys Leu Ser Trp 
145                 150                 155                 160 


Asn Glu Lys Lys Phe Arg Pro Leu Ser Ser Glu Leu Phe Ala Glu Leu 
                165                 170                 175     


Asn Lys Pro Gln Glu Ser Ala Ala Lys Cys Gln Lys Pro Val Arg Ala 
            180                 185                 190         


Lys Ser Lys Ser Ala Glu Ser Pro Ser Trp Thr Pro Ala Glu His Val 
        195                 200                 205             


Ala Lys Arg Ile Glu Ser Arg His Ser Ala Ser Lys Ser Arg Gln Thr 
    210                 215                 220                 


Pro Thr His Pro Leu Thr Pro Arg Ala Arg Lys Arg Leu Glu Leu Gly 
225                 230                 235                 240 


Asn Leu Gly Asn Pro Gln Met Ser Gln Gln Thr Ser Cys Ala Ser Leu 
                245                 250                 255     


Asp Ser Pro Gly Arg Ile Lys Arg Lys Val Ala Phe Ser Glu Ile Thr 
            260                 265                 270         


Ser Pro Ser Lys Arg Ser Gln Pro Asp Lys Leu Gln Thr Leu Ser Pro 
        275                 280                 285             


Ala Leu Lys Ala Pro Glu Lys Thr Arg Glu Thr Gly Leu Ser Tyr Thr 
    290                 295                 300                 


Glu Asp Asp Lys Lys Ala Ser Pro Glu His Arg Ile Ile Leu Arg Thr 
305                 310                 315                 320 


Arg Ile Ala Ala Ser Lys Thr Ile Asp Ile Arg Glu Glu Arg Thr Leu 
                325                 330                 335     


Thr Pro Ile Ser Gly Gly Gln Arg Ser Ser Val Val Pro Ser Val Ile 
            340                 345                 350         


Leu Lys Pro Glu Asn Ile Lys Lys Arg Asp Ala Lys Glu Ala Lys Ala 
        355                 360                 365             


Gln Asn Glu Ala Thr Ser Thr Pro His Arg Ile Arg Arg Lys Ser Ser 
    370                 375                 380                 


Val Leu Thr Met Asn Arg Ile Arg Gln Gln Leu Arg Phe Leu Gly Asn 
385                 390                 395                 400 


Ser Lys Ser Asp Gln Glu Glu Lys Glu Ile Leu Pro Ala Ala Glu Ile 
                405                 410                 415     


Ser Asp Ser Ser Ser Asp Glu Glu Glu Ala Ser Thr Pro Pro Leu Pro 
            420                 425                 430         


Arg Arg Ala Pro Arg Thr Val Ser Arg Asn Leu Arg Ser Ser Leu Lys 
        435                 440                 445             


Ser Ser Leu His Thr Leu Thr Lys Val Pro Lys Lys Ser Leu Lys Pro 
    450                 455                 460                 


Arg Thr Pro Arg Cys Ala Ala Pro Gln Ile Arg Ser Arg Ser Leu Ala 
465                 470                 475                 480 


Ala Gln Glu Pro Ala Ser Val Leu Glu Glu Ala Arg Leu Arg Leu His 
                485                 490                 495     


Val Ser Ala Val Pro Glu Ser Leu Pro Cys Arg Glu Gln Glu Phe Gln 
            500                 505                 510         


Asp Ile Tyr Asn Phe Val Glu Ser Lys Leu Leu Asp His Thr Gly Gly 
        515                 520                 525             


Cys Met Tyr Ile Ser Gly Val Pro Gly Thr Gly Lys Thr Ala Thr Val 
    530                 535                 540                 


His Glu Val Ile Arg Cys Leu Gln Gln Ala Ala Gln Ala Asn Asp Val 
545                 550                 555                 560 


Pro Pro Phe Gln Tyr Ile Glu Val Asn Gly Met Lys Leu Thr Glu Pro 
                565                 570                 575     


His Gln Val Tyr Val Gln Ile Leu Gln Lys Leu Thr Gly Gln Lys Ala 
            580                 585                 590         


Thr Ala Asn His Ala Ala Glu Leu Leu Ala Lys Gln Phe Cys Thr Arg 
        595                 600                 605             


Gly Ser Pro Gln Glu Thr Thr Val Leu Leu Val Asp Glu Leu Asp Leu 
    610                 615                 620                 


Leu Trp Thr His Lys Gln Asp Ile Met Tyr Asn Leu Phe Asp Trp Pro 
625                 630                 635                 640 


Thr His Lys Glu Ala Arg Leu Val Val Leu Ala Ile Ala Asn Thr Met 
                645                 650                 655     


Asp Leu Pro Glu Arg Ile Met Met Asn Arg Val Ser Ser Arg Leu Gly 
            660                 665                 670         


Leu Thr Arg Met Cys Phe Gln Pro Tyr Thr Tyr Ser Gln Leu Gln Gln 
        675                 680                 685             


Ile Leu Arg Ser Arg Leu Lys His Leu Lys Ala Phe Glu Asp Asp Ala 
    690                 695                 700                 


Ile Gln Leu Val Ala Arg Lys Val Ala Ala Leu Ser Gly Asp Ala Arg 
705                 710                 715                 720 


Arg Cys Leu Asp Ile Cys Arg Arg Ala Thr Glu Ile Cys Glu Phe Ser 
                725                 730                 735     


Gln Gln Lys Pro Asp Ser Pro Gly Leu Val Thr Ile Ala His Ser Met 
            740                 745                 750         


Glu Ala Val Asp Glu Met Phe Ser Ser Ser Tyr Ile Thr Ala Ile Lys 
        755                 760                 765             


Asn Ser Ser Val Leu Glu Gln Ser Phe Leu Arg Ala Ile Leu Ala Glu 
    770                 775                 780                 


Phe Arg Arg Ser Gly Leu Glu Glu Ala Thr Phe Gln Gln Ile Tyr Ser 
785                 790                 795                 800 


Gln His Val Ala Leu Cys Arg Met Glu Gly Leu Pro Tyr Pro Thr Met 
                805                 810                 815     


Ser Glu Thr Met Ala Val Cys Ser His Leu Gly Ser Cys Arg Leu Leu 
            820                 825                 830         


Leu Val Glu Pro Ser Arg Asn Asp Leu Leu Leu Arg Val Arg Leu Asn 
        835                 840                 845             


Val Ser Gln Asp Asp Val Leu Tyr Ala Leu Lys Asp Glu 
    850                 855                 860     


<210>  58
<211>  647
<212>  PRT
<213>  Homo sapiens

<400>  58

Met Gly Pro Leu Ser Ala Arg Leu Leu Met Gln Arg Gly Arg Pro Lys 
1               5                   10                  15      


Ser Asp Arg Leu Gly Lys Ile Arg Ser Leu Asp Leu Ser Gly Leu Glu 
            20                  25                  30          


Leu Leu Ser Glu His Leu Asp Pro Lys Leu Leu Cys Arg Leu Thr Gln 
        35                  40                  45              


Leu Gln Glu Leu Asp Leu Ser Asn Asn His Leu Glu Thr Leu Pro Asp 
    50                  55                  60                  


Asn Leu Gly Leu Ser His Leu Arg Val Leu Arg Cys Ala Asn Asn Gln 
65                  70                  75                  80  


Leu Gly Asp Val Thr Ala Leu Cys Gln Phe Pro Lys Leu Glu Glu Leu 
                85                  90                  95      


Ser Leu Glu Gly Asn Pro Phe Leu Thr Val Asn Asp Asn Leu Lys Val 
            100                 105                 110         


Ser Phe Leu Leu Pro Thr Leu Arg Lys Val Asn Gly Lys Asp Ala Ser 
        115                 120                 125             


Ser Thr Tyr Ser Gln Val Glu Asn Leu Asn Arg Glu Leu Thr Ser Arg 
    130                 135                 140                 


Val Thr Ala His Trp Glu Lys Phe Met Ala Thr Leu Gly Pro Glu Glu 
145                 150                 155                 160 


Glu Ala Glu Lys Ala Gln Ala Asp Phe Val Lys Ser Ala Val Arg Asp 
                165                 170                 175     


Val Arg Tyr Gly Pro Glu Ser Leu Ser Glu Phe Thr Gln Trp Arg Val 
            180                 185                 190         


Arg Met Ile Ser Glu Glu Leu Val Ala Ala Ser Arg Thr Gln Val Gln 
        195                 200                 205             


Lys Ala Asn Ser Pro Glu Lys Pro Pro Glu Ala Gly Ala Ala His Lys 
    210                 215                 220                 


Pro Arg Ala Arg Leu Ala Ala Leu Lys Arg Pro Asp Asp Val Pro Leu 
225                 230                 235                 240 


Ser Leu Ser Pro Ser Lys Arg Ala Cys Ala Ser Pro Ser Ala Gln Val 
                245                 250                 255     


Glu Gly Ser Pro Val Ala Gly Ser Asp Gly Ser Gln Pro Ala Val Lys 
            260                 265                 270         


Leu Glu Pro Leu His Phe Leu Gln Cys His Ser Lys Asn Asn Ser Pro 
        275                 280                 285             


Gln Asp Leu Glu Thr Gln Leu Trp Ala Cys Ala Phe Glu Pro Ala Trp 
    290                 295                 300                 


Glu Glu Gly Ala Thr Ser Gln Thr Val Ala Thr Cys Gly Gly Glu Ala 
305                 310                 315                 320 


Val Cys Val Ile Asp Cys Gln Thr Gly Ile Val Leu His Lys Tyr Lys 
                325                 330                 335     


Ala Pro Gly Glu Glu Phe Phe Ser Val Ala Trp Thr Ala Leu Met Val 
            340                 345                 350         


Val Thr Gln Ala Gly His Lys Lys Arg Trp Ser Val Leu Ala Ala Ala 
        355                 360                 365             


Gly Leu Arg Gly Leu Val Arg Leu Leu His Val Arg Ala Gly Phe Cys 
    370                 375                 380                 


Cys Gly Val Ile Arg Ala His Lys Lys Ala Ile Ala Thr Leu Cys Phe 
385                 390                 395                 400 


Ser Pro Ala His Glu Thr His Leu Phe Thr Ala Ser Tyr Asp Lys Arg 
                405                 410                 415     


Ile Ile Leu Trp Asp Ile Gly Val Pro Asn Gln Asp Tyr Glu Phe Gln 
            420                 425                 430         


Ala Ser Gln Leu Leu Thr Leu Asp Thr Thr Ser Ile Pro Leu Arg Leu 
        435                 440                 445             


Cys Pro Val Ala Ser Cys Pro Asp Ala Arg Leu Leu Ala Gly Cys Glu 
    450                 455                 460                 


Gly Gly Cys Cys Cys Trp Asp Val Arg Leu Asp Gln Pro Gln Lys Arg 
465                 470                 475                 480 


Arg Val Cys Glu Val Glu Phe Val Phe Ser Glu Gly Ser Glu Ala Ser 
                485                 490                 495     


Gly Arg Arg Val Asp Gly Leu Ala Phe Val Asn Glu Asp Ile Val Ala 
            500                 505                 510         


Ser Lys Gly Ser Gly Leu Gly Thr Ile Cys Leu Trp Ser Trp Arg Gln 
        515                 520                 525             


Thr Trp Gly Gly Arg Gly Ser Gln Ser Thr Val Ala Val Val Val Leu 
    530                 535                 540                 


Ala Arg Leu Gln Trp Ser Ser Thr Glu Leu Ala Tyr Phe Ser Leu Ser 
545                 550                 555                 560 


Ala Cys Pro Asp Lys Gly Ile Val Leu Cys Gly Asp Glu Glu Gly Asn 
                565                 570                 575     


Val Trp Leu Tyr Asp Val Ser Asn Ile Leu Lys Gln Pro Pro Leu Leu 
            580                 585                 590         


Pro Ala Ala Leu Gln Ala Pro Thr Gln Ile Leu Lys Trp Pro Gln Pro 
        595                 600                 605             


Trp Ala Leu Gly Gln Val Val Thr Lys Thr Met Val Asn Thr Val Val 
    610                 615                 620                 


Ala Asn Ala Ser Phe Thr Tyr Leu Thr Ala Leu Thr Asp Ser Asn Ile 
625                 630                 635                 640 


Val Ala Ile Trp Gly Arg Met 
                645         


<210>  59
<211>  43
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Ring finger domain of humain Obi1

<400>  59

Thr Cys His Ile Cys Leu Gly Lys Val Arg Gln Pro Val Ile Cys Ile 
1               5                   10                  15      


Asn Asn His Val Phe Cys Ser Ile Cys Ile Asp Leu Trp Leu Lys Asn 
            20                  25                  30          


Asn Ser Gln Cys Pro Ala Cys Arg Val Pro Ile 
        35                  40              


<210>  60
<211>  259
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  RING + Coil-coiled domain

<400>  60

Thr Cys His Ile Cys Leu Gly Lys Val Arg Gln Pro Val Ile Cys Ile 
1               5                   10                  15      


Asn Asn His Val Phe Cys Ser Ile Cys Ile Asp Leu Trp Leu Lys Asn 
            20                  25                  30          


Asn Ser Gln Cys Pro Ala Cys Arg Val Pro Ile Thr Pro Glu Asn Pro 
        35                  40                  45              


Cys Lys Glu Ile Ile Gly Gly Thr Ser Glu Ser Glu Pro Met Leu Ser 
    50                  55                  60                  


His Thr Val Arg Lys His Leu Arg Lys Thr Arg Leu Glu Leu Leu His 
65                  70                  75                  80  


Lys Glu Tyr Glu Asp Glu Ile Asp Cys Leu Gln Lys Glu Val Glu Glu 
                85                  90                  95      


Leu Lys Ser Lys Asn Leu Ser Leu Glu Ser Gln Ile Lys Thr Ile Leu 
            100                 105                 110         


Asp Pro Leu Thr Leu Val Gln Gly Asn Gln Asn Glu Asp Lys His Leu 
        115                 120                 125             


Val Thr Asp Asn Pro Ser Lys Ile Asn Pro Glu Thr Val Ala Glu Trp 
    130                 135                 140                 


Lys Lys Lys Leu Arg Thr Ala Asn Glu Ile Tyr Glu Lys Val Lys Asp 
145                 150                 155                 160 


Asp Val Asp Lys Leu Lys Glu Ala Asn Lys Lys Leu Lys Leu Glu Asn 
                165                 170                 175     


Gly Gly Leu Val Arg Glu Asn Leu Arg Leu Lys Ala Glu Val Asp Asn 
            180                 185                 190         


Arg Ser Pro Gln Lys Phe Gly Arg Phe Ala Val Ala Ala Leu Gln Ser 
        195                 200                 205             


Lys Val Glu Gln Tyr Glu Arg Glu Thr Asn Arg Leu Lys Lys Ala Leu 
    210                 215                 220                 


Glu Arg Ser Asp Lys Tyr Ile Glu Glu Leu Glu Ser Gln Val Ala Gln 
225                 230                 235                 240 


Leu Lys Asn Ser Ser Glu Glu Lys Glu Ala Met Asn Ser Ile Cys Gln 
                245                 250                 255     


Thr Ala Leu 
            


<210>  61
<211>  237
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  RING domain and coil-coiled domain

<400>  61

Thr Cys His Ile Cys Leu Gly Lys Val Arg Gln Pro Val Ile Cys Ile 
1               5                   10                  15      


Asn Asn His Val Phe Cys Ser Ile Cys Ile Asp Leu Trp Leu Lys Asn 
            20                  25                  30          


Asn Ser Gln Cys Pro Ala Cys Arg Val Pro Ile Val Arg Lys His Leu 
        35                  40                  45              


Arg Lys Thr Arg Leu Glu Leu Leu His Lys Glu Tyr Glu Asp Glu Ile 
    50                  55                  60                  


Asp Cys Leu Gln Lys Glu Val Glu Glu Leu Lys Ser Lys Asn Leu Ser 
65                  70                  75                  80  


Leu Glu Ser Gln Ile Lys Thr Ile Leu Asp Pro Leu Thr Leu Val Gln 
                85                  90                  95      


Gly Asn Gln Asn Glu Asp Lys His Leu Val Thr Asp Asn Pro Ser Lys 
            100                 105                 110         


Ile Asn Pro Glu Thr Val Ala Glu Trp Lys Lys Lys Leu Arg Thr Ala 
        115                 120                 125             


Asn Glu Ile Tyr Glu Lys Val Lys Asp Asp Val Asp Lys Leu Lys Glu 
    130                 135                 140                 


Ala Asn Lys Lys Leu Lys Leu Glu Asn Gly Gly Leu Val Arg Glu Asn 
145                 150                 155                 160 


Leu Arg Leu Lys Ala Glu Val Asp Asn Arg Ser Pro Gln Lys Phe Gly 
                165                 170                 175     


Arg Phe Ala Val Ala Ala Leu Gln Ser Lys Val Glu Gln Tyr Glu Arg 
            180                 185                 190         


Glu Thr Asn Arg Leu Lys Lys Ala Leu Glu Arg Ser Asp Lys Tyr Ile 
        195                 200                 205             


Glu Glu Leu Glu Ser Gln Val Ala Gln Leu Lys Asn Ser Ser Glu Glu 
    210                 215                 220                 


Lys Glu Ala Met Asn Ser Ile Cys Gln Thr Ala Leu Ser 
225                 230                 235         


<210>  62
<211>  493
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Ring and C-ter domain

<400>  62

Thr Cys His Ile Cys Leu Gly Lys Val Arg Gln Pro Val Ile Cys Ile 
1               5                   10                  15      


Asn Asn His Val Phe Cys Ser Ile Cys Ile Asp Leu Trp Leu Lys Asn 
            20                  25                  30          


Asn Ser Gln Cys Pro Ala Cys Arg Val Pro Ile Ala Asp Gly Lys Gly 
        35                  40                  45              


Ser Lys Gly Ser Glu Glu Asp Val Val Ser Lys Asn Gln Gly Asp Ser 
    50                  55                  60                  


Ala Arg Lys Gln Pro Gly Ser Ser Thr Ser Ser Ser Ser His Leu Ala 
65                  70                  75                  80  


Lys Pro Ser Ser Ser Arg Leu Cys Asp Thr Ser Ser Ala Arg Gln Glu 
                85                  90                  95      


Ser Thr Ser Lys Ala Asp Leu Asn Cys Ser Lys Asn Lys Asp Leu Tyr 
            100                 105                 110         


Gln Glu Gln Val Glu Val Met Leu Asp Val Thr Asp Thr Ser Met Asp 
        115                 120                 125             


Thr Tyr Leu Glu Arg Glu Trp Gly Asn Lys Pro Ser Asp Cys Val Pro 
    130                 135                 140                 


Tyr Lys Asp Glu Glu Leu Tyr Asp Leu Pro Ala Pro Cys Thr Pro Leu 
145                 150                 155                 160 


Ser Leu Ser Cys Leu Gln Leu Ser Thr Pro Glu Asn Arg Glu Ser Ser 
                165                 170                 175     


Val Val Gln Ala Gly Gly Ser Lys Lys His Ser Asn His Leu Arg Lys 
            180                 185                 190         


Leu Val Phe Asp Asp Phe Cys Asp Ser Ser Asn Val Ser Asn Lys Asp 
        195                 200                 205             


Ser Ser Glu Asp Asp Ile Ser Arg Ser Glu Asn Glu Lys Lys Ser Glu 
    210                 215                 220                 


Cys Phe Ser Ser Pro Lys Thr Gly Phe Trp Asp Cys Cys Ser Thr Ser 
225                 230                 235                 240 


Tyr Ala Gln Asn Leu Asp Phe Glu Ser Ser Glu Gly Asn Thr Ile Ala 
                245                 250                 255     


Asn Ser Val Gly Glu Ile Ser Ser Lys Leu Ser Glu Lys Ser Gly Leu 
            260                 265                 270         


Cys Leu Ser Lys Arg Leu Asn Ser Ile Arg Ser Phe Glu Met Asn Arg 
        275                 280                 285             


Thr Arg Thr Ser Ser Glu Ala Ser Met Asp Ala Ala Tyr Leu Asp Lys 
    290                 295                 300                 


Ile Ser Glu Leu Asp Ser Met Met Ser Glu Ser Asp Asn Ser Lys Ser 
305                 310                 315                 320 


Pro Cys Asn Asn Gly Phe Lys Ser Leu Asp Leu Asp Gly Leu Ser Lys 
                325                 330                 335     


Ser Ser Gln Gly Ser Glu Phe Leu Glu Glu Pro Asp Lys Leu Glu Glu 
            340                 345                 350         


Lys Thr Glu Leu Asn Leu Ser Lys Gly Ser Leu Thr Asn Asp Gln Leu 
        355                 360                 365             


Glu Asn Gly Ser Glu Trp Lys Pro Thr Ser Phe Phe Leu Leu Ser Pro 
    370                 375                 380                 


Ser Asp Gln Glu Met Asn Glu Asp Phe Ser Leu His Ser Ser Ser Cys 
385                 390                 395                 400 


Pro Val Thr Asn Glu Ile Lys Pro Pro Ser Cys Leu Phe Gln Thr Glu 
                405                 410                 415     


Phe Ser Gln Gly Ile Leu Leu Ser Ser Ser His Arg Leu Phe Glu Asp 
            420                 425                 430         


Gln Arg Phe Gly Ser Ser Leu Phe Lys Met Ser Ser Glu Met His Ser 
        435                 440                 445             


Leu His Asn His Leu Gln Ser Pro Trp Ser Thr Ser Phe Val Pro Glu 
    450                 455                 460                 


Lys Arg Asn Lys Asn Val Asn Gln Ser Thr Lys Arg Lys Ile Gln Ser 
465                 470                 475                 480 


Ser Leu Ser Ser Ala Ser Pro Ser Lys Ala Thr Lys Ser 
                485                 490             


<210>  63
<211>  644
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Coil-coiled domain and Cter domain

<400>  63

Val Arg Lys His Leu Arg Lys Thr Arg Leu Glu Leu Leu His Lys Glu 
1               5                   10                  15      


Tyr Glu Asp Glu Ile Asp Cys Leu Gln Lys Glu Val Glu Glu Leu Lys 
            20                  25                  30          


Ser Lys Asn Leu Ser Leu Glu Ser Gln Ile Lys Thr Ile Leu Asp Pro 
        35                  40                  45              


Leu Thr Leu Val Gln Gly Asn Gln Asn Glu Asp Lys His Leu Val Thr 
    50                  55                  60                  


Asp Asn Pro Ser Lys Ile Asn Pro Glu Thr Val Ala Glu Trp Lys Lys 
65                  70                  75                  80  


Lys Leu Arg Thr Ala Asn Glu Ile Tyr Glu Lys Val Lys Asp Asp Val 
                85                  90                  95      


Asp Lys Leu Lys Glu Ala Asn Lys Lys Leu Lys Leu Glu Asn Gly Gly 
            100                 105                 110         


Leu Val Arg Glu Asn Leu Arg Leu Lys Ala Glu Val Asp Asn Arg Ser 
        115                 120                 125             


Pro Gln Lys Phe Gly Arg Phe Ala Val Ala Ala Leu Gln Ser Lys Val 
    130                 135                 140                 


Glu Gln Tyr Glu Arg Glu Thr Asn Arg Leu Lys Lys Ala Leu Glu Arg 
145                 150                 155                 160 


Ser Asp Lys Tyr Ile Glu Glu Leu Glu Ser Gln Val Ala Gln Leu Lys 
                165                 170                 175     


Asn Ser Ser Glu Glu Lys Glu Ala Met Asn Ser Ile Cys Gln Thr Ala 
            180                 185                 190         


Leu Ser Ala Asp Gly Lys Gly Ser Lys Gly Ser Glu Glu Asp Val Val 
        195                 200                 205             


Ser Lys Asn Gln Gly Asp Ser Ala Arg Lys Gln Pro Gly Ser Ser Thr 
    210                 215                 220                 


Ser Ser Ser Ser His Leu Ala Lys Pro Ser Ser Ser Arg Leu Cys Asp 
225                 230                 235                 240 


Thr Ser Ser Ala Arg Gln Glu Ser Thr Ser Lys Ala Asp Leu Asn Cys 
                245                 250                 255     


Ser Lys Asn Lys Asp Leu Tyr Gln Glu Gln Val Glu Val Met Leu Asp 
            260                 265                 270         


Val Thr Asp Thr Ser Met Asp Thr Tyr Leu Glu Arg Glu Trp Gly Asn 
        275                 280                 285             


Lys Pro Ser Asp Cys Val Pro Tyr Lys Asp Glu Glu Leu Tyr Asp Leu 
    290                 295                 300                 


Pro Ala Pro Cys Thr Pro Leu Ser Leu Ser Cys Leu Gln Leu Ser Thr 
305                 310                 315                 320 


Pro Glu Asn Arg Glu Ser Ser Val Val Gln Ala Gly Gly Ser Lys Lys 
                325                 330                 335     


His Ser Asn His Leu Arg Lys Leu Val Phe Asp Asp Phe Cys Asp Ser 
            340                 345                 350         


Ser Asn Val Ser Asn Lys Asp Ser Ser Glu Asp Asp Ile Ser Arg Ser 
        355                 360                 365             


Glu Asn Glu Lys Lys Ser Glu Cys Phe Ser Ser Pro Lys Thr Gly Phe 
    370                 375                 380                 


Trp Asp Cys Cys Ser Thr Ser Tyr Ala Gln Asn Leu Asp Phe Glu Ser 
385                 390                 395                 400 


Ser Glu Gly Asn Thr Ile Ala Asn Ser Val Gly Glu Ile Ser Ser Lys 
                405                 410                 415     


Leu Ser Glu Lys Ser Gly Leu Cys Leu Ser Lys Arg Leu Asn Ser Ile 
            420                 425                 430         


Arg Ser Phe Glu Met Asn Arg Thr Arg Thr Ser Ser Glu Ala Ser Met 
        435                 440                 445             


Asp Ala Ala Tyr Leu Asp Lys Ile Ser Glu Leu Asp Ser Met Met Ser 
    450                 455                 460                 


Glu Ser Asp Asn Ser Lys Ser Pro Cys Asn Asn Gly Phe Lys Ser Leu 
465                 470                 475                 480 


Asp Leu Asp Gly Leu Ser Lys Ser Ser Gln Gly Ser Glu Phe Leu Glu 
                485                 490                 495     


Glu Pro Asp Lys Leu Glu Glu Lys Thr Glu Leu Asn Leu Ser Lys Gly 
            500                 505                 510         


Ser Leu Thr Asn Asp Gln Leu Glu Asn Gly Ser Glu Trp Lys Pro Thr 
        515                 520                 525             


Ser Phe Phe Leu Leu Ser Pro Ser Asp Gln Glu Met Asn Glu Asp Phe 
    530                 535                 540                 


Ser Leu His Ser Ser Ser Cys Pro Val Thr Asn Glu Ile Lys Pro Pro 
545                 550                 555                 560 


Ser Cys Leu Phe Gln Thr Glu Phe Ser Gln Gly Ile Leu Leu Ser Ser 
                565                 570                 575     


Ser His Arg Leu Phe Glu Asp Gln Arg Phe Gly Ser Ser Leu Phe Lys 
            580                 585                 590         


Met Ser Ser Glu Met His Ser Leu His Asn His Leu Gln Ser Pro Trp 
        595                 600                 605             


Ser Thr Ser Phe Val Pro Glu Lys Arg Asn Lys Asn Val Asn Gln Ser 
    610                 615                 620                 


Thr Lys Arg Lys Ile Gln Ser Ser Leu Ser Ser Ala Ser Pro Ser Lys 
625                 630                 635                 640 


Ala Thr Lys Ser 
                


<210>  64
<211>  35
<212>  DNA
<213>  Artificial sequence

<220>
<223>  derived from ORC1

<400>  64
ctggcggccg caccatggca cactacccca caagg                                  35


<210>  65
<211>  30
<212>  DNA
<213>  Artificial sequence

<220>
<223>  derived from ORC1

<400>  65
ctggcggccg cctcgtcttt cagcgcatac                                        30


<210>  66
<211>  40
<212>  DNA
<213>  Artificial sequence

<220>
<223>  derived from  ORC2

<400>  66
ctggcggccg caccatgagt aaaccagaat taaaggaaga                             40


<210>  67
<211>  32
<212>  DNA
<213>  Artificial sequence

<220>
<223>  derived from ORC2

<400>  67
ctggcggccg cagcctcctc ttcttccttt tc                                     32


<210>  68
<211>  30
<212>  DNA
<213>  Artificial sequence

<220>
<223>  derived from LRWD1

<400>  68
ctggcggccg caccatgggc cccctctcgg                                        30


<210>  69
<211>  28
<212>  DNA
<213>  Artificial sequence

<220>
<223>  derived from LRWD1

<400>  69
ctggcggccg ccatcctccc ccagatgg                                          28


<210>  70
<211>  50
<212>  DNA
<213>  Artificial sequence

<220>
<223>  derived from FLAG tag

<400>  70
gatccgccaa catggactac aaggacgacg atgacaagtc catggctggg                  50


<210>  71
<211>  50
<212>  DNA
<213>  Artificial sequence

<220>
<223>  derived from FLAG tag

<400>  71
aattcccagc catggacttg tcatcgtcgt ccttgtagtc catgttggcg                  50


<210>  72
<211>  34
<212>  DNA
<213>  Artificial sequence

<220>
<223>  derived from ORC1

<400>  72
ctgtctagag ccatggcaca ctaccccaca aggc                                   34


<210>  73
<211>  31
<212>  DNA
<213>  Artificial sequence

<220>
<223>  derived from ORC1

<400>  73
ctgtctagat tactcgtctt tcagcgcata c                                      31


<210>  74
<211>  35
<212>  DNA
<213>  Artificial sequence

<220>
<223>  derived from ORC2

<400>  74
ctgccatggg aagtaaacca gaattaaagg aagac                                  35


<210>  75
<211>  30
<212>  DNA
<213>  Artificial sequence

<220>
<223>  derived from ORC2

<400>  75
ctgctcgagt caagcctcct cttcttcctt                                        30


<210>  76
<211>  22
<212>  DNA
<213>  Artificial sequence

<220>
<223>  derived from ORC3

<400>  76
ctgccatggc tacgtcctcg at                                                22


<210>  77
<211>  30
<212>  DNA
<213>  Artificial sequence

<220>
<223>  derived from ORC3

<400>  77
ctgtctagat tagcagcctc cccatgttag                                        30


<210>  78
<211>  29
<212>  DNA
<213>  Artificial sequence

<220>
<223>  derived from ORC4

<400>  78
ctgctcgaga gcagtcgtaa atcaaagag                                         29


<210>  79
<211>  32
<212>  DNA
<213>  Artificial sequence

<220>
<223>  derived from ORC4

<400>  79
ctgtctagat tataaccagc ttagtgagga tg                                     32


<210>  80
<211>  29
<212>  DNA
<213>  Artificial sequence

<220>
<223>  derived from ORC5

<400>  80
ctggaattct ccccacttgg aaaacgtgg                                         29


<210>  81
<211>  33
<212>  DNA
<213>  Artificial sequence

<220>
<223>  derived from ORC5

<400>  81
ctgctcgagt cacaagaaat catacaagta ttt                                    33


<210>  82
<211>  25
<212>  DNA
<213>  Artificial sequence

<220>
<223>  derived from ORC6

<400>  82
ctgctcgagg ggtcggagct gatcg                                             25


<210>  83
<211>  31
<212>  DNA
<213>  Artificial sequence

<220>
<223>  derived from ORC6

<400>  83
ctgtctagat tactctgctg tagccttttg a                                      31


<210>  84
<211>  18
<212>  DNA
<213>  Artificial sequence

<220>
<223>  derived from obi1

<400>  84
ctgccatggc tcagaccg                                                     18


<210>  85
<211>  34
<212>  DNA
<213>  Artificial sequence

<220>
<223>  derived from obi1

<400>  85
ctgtctagat taacttttag ttgcttttga tggg                                   34


<210>  86
<211>  27
<212>  DNA
<213>  Artificial sequence

<220>
<223>  derived from obi1

<400>  86
ctgccatggc ttgcagagtc cccatca                                           27


<210>  87
<211>  32
<212>  DNA
<213>  Artificial sequence

<220>
<223>  derived from obi1

<400>  87
ctgtctagat tatttgccat ctgcagaaag tg                                     32


<210>  88
<211>  26
<212>  DNA
<213>  Artificial sequence

<220>
<223>  derived from obi1

<400>  88
ctgccatggg gagcaaaggc agtgag                                            26


<210>  89
<211>  32
<212>  DNA
<213>  Artificial sequence

<220>
<223>  derived from obi1

<400>  89
ctgccatgga tcctcctata atttctttgc aa                                     32


<210>  90
<211>  30
<212>  DNA
<213>  Artificial sequence

<220>
<223>  derived from obi1

<400>  90
ctggaattct atggcgcaga ctgttcagaa                                        30


<210>  91
<211>  32
<212>  DNA
<213>  Artificial sequence

<220>
<223>  derived from obi1

<400>  91
ctgctcgagt catggcttaa aggactttgg ag                                     32


<210>  92
<211>  40
<212>  DNA
<213>  Artificial sequence

<220>
<223>  derived from cdt1

<400>  92
aattctatgt atgatgttcc tgattatgct agcctctaat                             40


<210>  93
<211>  40
<212>  DNA
<213>  Artificial sequence

<220>
<223>  derived from cdt1

<400>  93
ctagattaga ggctagcata atcaggaaca tcatacatag                             40


<210>  94
<211>  27
<212>  DNA
<213>  Artificial sequence

<220>
<223>  derived from cdt1

<400>  94
ctgaagctta ccatggagca gcgccgc                                           27


<210>  95
<211>  25
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  derived from cdt1

<400>  95
ctggaattca gcccctcctc agcac                                             25


<210>  96
<211>  3552
<212>  DNA
<213>  Homo sapiens

<400>  96
ggcgaagagt agcggtaggt cggcgggact tccgtgttgg cgggattctg aacgctgcca       60

tggctcagac cgtgcagaat gttacattgt cgctcactct gcccatcacg tgccacattt      120

gcttggggaa ggtacgtcag cctgtcatat gcatcaacaa ccatgtattt tgttcgattt      180

gtattgattt gtggttgaag aataatagcc agtgtccagc ttgcagagtc cccatcactc      240

ctgaaaatcc ttgcaaagaa attataggag gaacaagtga aagtgaacct atgctaagcc      300

atacggtcag gaagcatctt cggaaaacta gacttgaatt actacacaaa gaatatgagg      360

acgaaataga ttgtttacag aaagaagtag aagagcttaa gagtaaaaat ctcagcttgg      420

agtcacagat caaaactatt ctggatcctt taaccttggt gcagggcaac caaaatgaag      480

acaaacatct agtcacagat aatccaagta aaattaaccc agaaactgta gcagagtgga      540

agaaaaaact cagaacagct aatgaaatct atgaaaaagt gaaagatgat gtggataagc      600

taaaggaggc aaataaaaaa ttgaaattgg aaaatggtgg tctggtgagg gagaatttac      660

gactgaaggc tgaagttgat aacagatcac ctcaaaagtt tggaaggttt gcagttgctg      720

ctcttcagtc caaagtagaa cagtatgagc gtgaaaccaa tcgcctcaag aaagccctgg      780

aacgaagtga taagtatata gaggaactag aatctcaagt tgcacagcta aaaaattcaa      840

gtgaagagaa agaagctatg aattccattt gccagacagc actttctgca gatggcaaag      900

ggagcaaagg cagtgaggag gatgtggtgt caaagaatca aggcgatagt gccagaaagc      960

agcctggctc atccacctcc agttcttctc acctagcgaa gccttccagc agcagactgt     1020

gtgacaccag ttctgcaagg caggaaagta ccagcaaagc agaccttaac tgttctaaga     1080

acaaagacct atatcaagaa caggtagaag taatgttaga tgtgacagat acaagtatgg     1140

atacttattt ggaaagagaa tgggggaata aaccaagtga ctgtgtaccc tacaaagatg     1200

aagaacttta tgatcttcca gctccttgta ctcctttgtc ccttagttgc cttcagctca     1260

gtactccaga aaatagagag agctctgtgg tccaagcagg aggttccaaa aagcactcaa     1320

accatctcag aaaattggtg tttgatgatt tttgtgattc ttcaaatgtt tctaataaag     1380

attcttcaga agatgatata agtagaagtg aaaatgaaaa gaaatcagaa tgtttttctt     1440

ccccaaagac aggattttgg gactgttgtt ccacaagcta tgcccaaaac ttagattttg     1500

aaagttcaga ggggaacacg atagcaaatt ctgttggaga aatatcttca aaattgagtg     1560

agaaatcagg cttatgttta tccaaaaggt tgaattctat tcgctctttt gaaatgaacc     1620

ggacaagaac atccagtgaa gcatcgatgg atgctgctta ccttgacaaa atctctgagt     1680

tggattcaat gatgtcagag tcagacaaca gcaagagccc ttgtaataac ggttttaagt     1740

cactggattt ggatgggtta tcaaagtcat ctcaaggcag tgaatttctt gaggaacctg     1800

ataagttgga agaaaaaact gagctaaacc tttccaaagg ttctctaact aatgatcagt     1860

tagaaaatgg aagtgaatgg aaacccactt ctttttttct cctctctcca tctgaccaag     1920

aaatgaatga agatttttca ctccattcca gttcttgtcc agtaactaat gaaatcaaac     1980

ccccaagctg cttgtttcag acagagtttt cccagggcat tttgttaagc agttcacatc     2040

gactatttga agatcaaaga tttgggtcat ctttgtttaa gatgtcctca gagatgcaca     2100

gtcttcataa ccaccttcag tctccttggt ctacttcctt tgtgcctgaa aagaggaata     2160

aaaatgtgaa tcaatcaaca aaaagaaaaa tccagagcag cctttccagt gccagcccat     2220

caaaagcaac taaaagttga ctcattagaa aggtgtcatt tgtggttttg tcctgagaga     2280

aatagaaaag ttgttaaagt tacctttttt cctcataaaa gttctataca aattggaatt     2340

gataatcttt agtcaagtat caagtcagga tggtggatta acctgtaccc agaatactta     2400

ttgttcattt tgaaaagact ttgttctttt catttttatt tgggagtctt tgtgaccaga     2460

gaagttaggg aggaggttat ttttgtgttt tggggttggt tggttggttg gttttgtttt     2520

tggttttgtt tttttactga atttgatatg tatctcggtt ggatatacat tgttttttta     2580

aaaaatgtta tttaactgtt agatacagtg gcctgttgat aagccccact tgtcttcaga     2640

acttggattt cttaaataaa acttttagtg ttgtctatac actgctcaat aagacacttg     2700

agtttaagct tttcccaggg tggaaattat tttacctgtc cctttttatt tatgtttagt     2760

gatggcctag tttttctgca gggccatgat ggagaaatag cactctagcc ttagtccaat     2820

attgatttac tttctttttt taggttttat gtatatgttt gcatttttta gcattgtgtt     2880

ttgtccagtt ttgtgaaaat gttctgctag tatgaaagaa aacattttct atatgaagac     2940

atttgtttta tgttaggtag cttacatttt ctcctctgcg tgtgtgtgta tgtgtgtaaa     3000

atcagaaatt tagcatacta tggaaagaag gcatggagca cttgggttta gaggaaccta     3060

aaacatcata gcttcattgt tccagatgta acaggtttga aagagctcat cgccaagttc     3120

ttgatccact tgcattccag gggagttttc ttttgagtag tatgtttctt gtttgcatgt     3180

tcctgttctt tgtggaaact atgcatggta gcatttttgc ttgctgtgtt ttccatactt     3240

aagaaaaaga ggtttcagtt ggctgataga atatctttta tgtaggacaa aacttttctg     3300

tgaagagtgt tgagggggtg aagataggta agaggtaagc acaattttta atttaggctc     3360

tgaaaaagtg tattgttcta aacgtatttg gtatgcctat ataggtcttt aaaaatgggt     3420

atgtatgctg tttaatgtgc actgaacatt ttacattaat attgtactgt tttacattaa     3480

tactgcatgc ttttctatgt gaattgaata aagaatgtca taagcactgt gttcaaaaaa     3540

aaaaaaaaaa aa                                                         3552


<210>  97
<211>  2181
<212>  DNA
<213>  Homo sapiens

<400>  97
atggctcaga ccgtgcagaa tgttacattg tcgctcactc tgcccatcac gtgccacatt       60

tgcttgggga aggtacgtca gcctgtcata tgcatcaaca accatgtatt ttgttcgatt      120

tgtattgatt tgtggttgaa gaataatagc cagtgtccag cttgcagagt ccccatcact      180

cctgaaaatc cttgcaaaga aattatagga ggaacaagtg aaagtgaacc tatgctaagc      240

catacggtca ggaagcatct tcggaaaact agacttgaat tactacacaa agaatatgag      300

gacgaaatag attgtttaca gaaagaagta gaagagctta agagtaaaaa tctcagcttg      360

gagtcacaga tcaaaactat tctggatcct ttaaccttgg tgcagggcaa ccaaaatgaa      420

gacaaacatc tagtcacaga taatccaagt aaaattaacc cagaaactgt agcagagtgg      480

aagaaaaaac tcagaacagc taatgaaatc tatgaaaaag tgaaagatga tgtggataag      540

ctaaaggagg caaataaaaa attgaaattg gaaaatggtg gtctggtgag ggagaattta      600

cgactgaagg ctgaagttga taacagatca cctcaaaagt ttggaaggtt tgcagttgct      660

gctcttcagt ccaaagtaga acagtatgag cgtgaaacca atcgcctcaa gaaagccctg      720

gaacgaagtg ataagtatat agaggaacta gaatctcaag ttgcacagct aaaaaattca      780

agtgaagaga aagaagctat gaattccatt tgccagacag cactttctgc agatggcaaa      840

gggagcaaag gcagtgagga ggatgtggtg tcaaagaatc aaggcgatag tgccagaaag      900

cagcctggct catccacctc cagttcttct cacctagcga agccttccag cagcagactg      960

tgtgacacca gttctgcaag gcaggaaagt accagcaaag cagaccttaa ctgttctaag     1020

aacaaagacc tatatcaaga acaggtagaa gtaatgttag atgtgacaga tacaagtatg     1080

gatacttatt tggaaagaga atgggggaat aaaccaagtg actgtgtacc ctacaaagat     1140

gaagaacttt atgatcttcc agctccttgt actcctttgt cccttagttg ccttcagctc     1200

agtactccag aaaatagaga gagctctgtg gtccaagcag gaggttccaa aaagcactca     1260

aaccatctca gaaaattggt gtttgatgat ttttgtgatt cttcaaatgt ttctaataaa     1320

gattcttcag aagatgatat aagtagaagt gaaaatgaaa agaaatcaga atgtttttct     1380

tccccaaaga caggattttg ggactgttgt tccacaagct atgcccaaaa cttagatttt     1440

gaaagttcag aggggaacac gatagcaaat tctgttggag aaatatcttc aaaattgagt     1500

gagaaatcag gcttatgttt atccaaaagg ttgaattcta ttcgctcttt tgaaatgaac     1560

cggacaagaa catccagtga agcatcgatg gatgctgctt accttgacaa aatctctgag     1620

ttggattcaa tgatgtcaga gtcagacaac agcaagagcc cttgtaataa cggttttaag     1680

tcactggatt tggatgggtt atcaaagtca tctcaaggca gtgaatttct tgaggaacct     1740

gataagttgg aagaaaaaac tgagctaaac ctttccaaag gttctctaac taatgatcag     1800

ttagaaaatg gaagtgaatg gaaacccact tctttttttc tcctctctcc atctgaccaa     1860

gaaatgaatg aagatttttc actccattcc agttcttgtc cagtaactaa tgaaatcaaa     1920

cccccaagct gcttgtttca gacagagttt tcccagggca ttttgttaag cagttcacat     1980

cgactatttg aagatcaaag atttgggtca tctttgttta agatgtcctc agagatgcac     2040

agtcttcata accaccttca gtctccttgg tctacttcct ttgtgcctga aaagaggaat     2100

aaaaatgtga atcaatcaac aaaaagaaaa atccagagca gcctttccag tgccagccca     2160

tcaaaagcaa ctaaaagttg a                                               2181


<210>  98
<211>  3550
<212>  DNA
<213>  Homo sapiens

<400>  98
ggcgaagagt agcggtaggt cggcgggact tccgtgttgg cgggattctg aacgctgcca       60

tggctcagac cgtgcagaat gttacattgt cgctcactct gcccatcacg tgccacattt      120

gcttggggaa ggtacgtcag cctgtcatat gcatcaacaa ccatgtattt tgttcgattt      180

gtattgattt gtggttgaag aataatagcc agtgtccagc ttgcagagtc cccatcactc      240

ctgaaaatcc ttgcaaagaa attataggag gaacaagtga aagtgaacct atgctaagcc      300

atacggtcag gaagcatctt cggaaaacta gacttgaatt actacacaaa gaatatgagg      360

acgaaataga ttgtttacag aaagaagtag aagagcttaa gagtaaaaat ctcagcttgg      420

agtcacagat caaaactatt ctggatcctt taaccttggt gcagggcaac caaaatgaag      480

acaaacatct agtcacagat aatccaagta aaattaaccc agaaactgta gcagagtgga      540

agaaaaaact cagaacagct aatgaaatct atgaaaaagt gaaagatgat gtggataagc      600

taaaggaggc aaataaaaaa ttgaaattgg aaaatggtgg tctggtgagg gagaatttac      660

gactgaaggc tgaagttgat aacagatcac ctcaaaagtt tggaaggttt gcagttgctg      720

ctcttcagtc caaagtagaa cagtatgagc gtgaaaccaa tcgcctcaag aaagccctgg      780

aacgaagtga taagtatata gaggaactag aatctcaagt tgcacagcta aaaaattcaa      840

gtgaagagaa agaagctatg aattccattt gccagacagc actttctgca gatggcaaag      900

ggagcaaagg cagtgaggag gatgtggtgt caaagaatca aggcgatagt gccagaaagc      960

agcctggctc atccacctcc agttcttctc acctagcgaa gccttccagc agcagactgt     1020

gtgacaccag ttctgcaagg caggaaagta ccagcaaagc agaccttaac tgttctaaga     1080

acaaagacct atatcaagaa caggtagaag taatgttaga tgtgacagat acaagtatgg     1140

atacttattt ggaaagagaa tgggggaata aaccaagtga ctgtgtaccc tacaaagatg     1200

aagaacttta tgatcttcca gctccttgta ctcctttgtc ccttagttgc cttcagctca     1260

gtactccaga aaatagagag agctctgtgg tccaagcagg aggttccaaa aagcactcaa     1320

accatctcag aaaattggtg tttgatgatt tttgtgattc ttcaaatgtt tctaataaag     1380

attcttcaga agatgatata agtagaagtg aaaatgaaaa gaaatcagtg tttttcttcc     1440

ccaaagacag gattttggga ctgttgttcc acaagctatg cccaaaactt agattttgaa     1500

agttcagagg ggaacacgat agcaaattct gttggagaaa tatcttcaaa attgagtgag     1560

aaatcaggct tatgtttatc caaaaggttg aattctattc gctcttttga aatgaaccgg     1620

acaagaacat ccagtgaagc atcgatggat gctgcttacc ttgacaaaat ctctgagttg     1680

gattcaatga tgtcagagtc agacaacagc aagagccctt gtaataacgg ttttaagtca     1740

ctggatttgg atgggttatc aaagtcatct caaggcagtg aatttcttga ggaacctgat     1800

aagttggaag aaaaaactga gctaaacctt tccaaaggtt ctctaactaa tgatcagtta     1860

gaaaatggaa gtgaatggaa acccacttct ttttttctcc tctctccatc tgaccaagaa     1920

atgaatgaag atttttcact ccattccagt tcttgtccag taactaatga aatcaaaccc     1980

ccaagctgct tgtttcagac agagttttcc cagggcattt tgttaagcag ttcacatcga     2040

ctatttgaag atcaaagatt tgggtcatct ttgtttaaga tgtcctcaga gatgcacagt     2100

cttcataacc accttcagtc tccttggtct acttcctttg tgcctgaaaa gaggaataaa     2160

aatgtgaatc aatcaacaaa aagaaaaatc cagagcagcc tttccagtgc cagcccatca     2220

aaagcaacta aaagttgact cattagaaag gtgtcatttg tggttttgtc ctgagagaaa     2280

tagaaaagtt gttaaagtta ccttttttcc tcataaaagt tctatacaaa ttggaattga     2340

taatctttag tcaagtatca agtcaggatg gtggattaac ctgtacccag aatacttatt     2400

gttcattttg aaaagacttt gttcttttca tttttatttg ggagtctttg tgaccagaga     2460

agttagggag gaggttattt ttgtgttttg gggttggttg gttggttggt tttgtttttg     2520

gttttgtttt tttactgaat ttgatatgta tctcggttgg atatacattg tttttttaaa     2580

aaatgttatt taactgttag atacagtggc ctgttgataa gccccacttg tcttcagaac     2640

ttggatttct taaataaaac ttttagtgtt gtctatacac tgctcaataa gacacttgag     2700

tttaagcttt tcccagggtg gaaattattt tacctgtccc tttttattta tgtttagtga     2760

tggcctagtt tttctgcagg gccatgatgg agaaatagca ctctagcctt agtccaatat     2820

tgatttactt tcttttttta ggttttatgt atatgtttgc attttttagc attgtgtttt     2880

gtccagtttt gtgaaaatgt tctgctagta tgaaagaaaa cattttctat atgaagacat     2940

ttgttttatg ttaggtagct tacattttct cctctgcgtg tgtgtgtatg tgtgtaaaat     3000

cagaaattta gcatactatg gaaagaaggc atggagcact tgggtttaga ggaacctaaa     3060

acatcatagc ttcattgttc cagatgtaac aggtttgaaa gagctcatcg ccaagttctt     3120

gatccacttg cattccaggg gagttttctt ttgagtagta tgtttcttgt ttgcatgttc     3180

ctgttctttg tggaaactat gcatggtagc atttttgctt gctgtgtttt ccatacttaa     3240

gaaaaagagg tttcagttgg ctgatagaat atcttttatg taggacaaaa cttttctgtg     3300

aagagtgttg agggggtgaa gataggtaag aggtaagcac aatttttaat ttaggctctg     3360

aaaaagtgta ttgttctaaa cgtatttggt atgcctatat aggtctttaa aaatgggtat     3420

gtatgctgtt taatgtgcac tgaacatttt acattaatat tgtactgttt tacattaata     3480

ctgcatgctt ttctatgtga attgaataaa gaatgtcata agcactgtgt tcaaaaaaaa     3540

aaaaaaaaaa                                                            3550


<210>  99
<211>  1440
<212>  DNA
<213>  Homo sapiens

<400>  99
atggctcaga ccgtgcagaa tgttacattg tcgctcactc tgcccatcac gtgccacatt       60

tgcttgggga aggtacgtca gcctgtcata tgcatcaaca accatgtatt ttgttcgatt      120

tgtattgatt tgtggttgaa gaataatagc cagtgtccag cttgcagagt ccccatcact      180

cctgaaaatc cttgcaaaga aattatagga ggaacaagtg aaagtgaacc tatgctaagc      240

catacggtca ggaagcatct tcggaaaact agacttgaat tactacacaa agaatatgag      300

gacgaaatag attgtttaca gaaagaagta gaagagctta agagtaaaaa tctcagcttg      360

gagtcacaga tcaaaactat tctggatcct ttaaccttgg tgcagggcaa ccaaaatgaa      420

gacaaacatc tagtcacaga taatccaagt aaaattaacc cagaaactgt agcagagtgg      480

aagaaaaaac tcagaacagc taatgaaatc tatgaaaaag tgaaagatga tgtggataag      540

ctaaaggagg caaataaaaa attgaaattg gaaaatggtg gtctggtgag ggagaattta      600

cgactgaagg ctgaagttga taacagatca cctcaaaagt ttggaaggtt tgcagttgct      660

gctcttcagt ccaaagtaga acagtatgag cgtgaaacca atcgcctcaa gaaagccctg      720

gaacgaagtg ataagtatat agaggaacta gaatctcaag ttgcacagct aaaaaattca      780

agtgaagaga aagaagctat gaattccatt tgccagacag cactttctgc agatggcaaa      840

gggagcaaag gcagtgagga ggatgtggtg tcaaagaatc aaggcgatag tgccagaaag      900

cagcctggct catccacctc cagttcttct cacctagcga agccttccag cagcagactg      960

tgtgacacca gttctgcaag gcaggaaagt accagcaaag cagaccttaa ctgttctaag     1020

aacaaagacc tatatcaaga acaggtagaa gtaatgttag atgtgacaga tacaagtatg     1080

gatacttatt tggaaagaga atgggggaat aaaccaagtg actgtgtacc ctacaaagat     1140

gaagaacttt atgatcttcc agctccttgt actcctttgt cccttagttg ccttcagctc     1200

agtactccag aaaatagaga gagctctgtg gtccaagcag gaggttccaa aaagcactca     1260

aaccatctca gaaaattggt gtttgatgat ttttgtgatt cttcaaatgt ttctaataaa     1320

gattcttcag aagatgatat aagtagaagt gaaaatgaaa agaaatcagt gtttttcttc     1380

cccaaagaca ggattttggg actgttgttc cacaagctat gcccaaaact tagattttga     1440


<210>  100
<211>  479
<212>  PRT
<213>  Homo sapiens

<400>  100

Met Ala Gln Thr Val Gln Asn Val Thr Leu Ser Leu Thr Leu Pro Ile 
1               5                   10                  15      


Thr Cys His Ile Cys Leu Gly Lys Val Arg Gln Pro Val Ile Cys Ile 
            20                  25                  30          


Asn Asn His Val Phe Cys Ser Ile Cys Ile Asp Leu Trp Leu Lys Asn 
        35                  40                  45              


Asn Ser Gln Cys Pro Ala Cys Arg Val Pro Ile Thr Pro Glu Asn Pro 
    50                  55                  60                  


Cys Lys Glu Ile Ile Gly Gly Thr Ser Glu Ser Glu Pro Met Leu Ser 
65                  70                  75                  80  


His Thr Val Arg Lys His Leu Arg Lys Thr Arg Leu Glu Leu Leu His 
                85                  90                  95      


Lys Glu Tyr Glu Asp Glu Ile Asp Cys Leu Gln Lys Glu Val Glu Glu 
            100                 105                 110         


Leu Lys Ser Lys Asn Leu Ser Leu Glu Ser Gln Ile Lys Thr Ile Leu 
        115                 120                 125             


Asp Pro Leu Thr Leu Val Gln Gly Asn Gln Asn Glu Asp Lys His Leu 
    130                 135                 140                 


Val Thr Asp Asn Pro Ser Lys Ile Asn Pro Glu Thr Val Ala Glu Trp 
145                 150                 155                 160 


Lys Lys Lys Leu Arg Thr Ala Asn Glu Ile Tyr Glu Lys Val Lys Asp 
                165                 170                 175     


Asp Val Asp Lys Leu Lys Glu Ala Asn Lys Lys Leu Lys Leu Glu Asn 
            180                 185                 190         


Gly Gly Leu Val Arg Glu Asn Leu Arg Leu Lys Ala Glu Val Asp Asn 
        195                 200                 205             


Arg Ser Pro Gln Lys Phe Gly Arg Phe Ala Val Ala Ala Leu Gln Ser 
    210                 215                 220                 


Lys Val Glu Gln Tyr Glu Arg Glu Thr Asn Arg Leu Lys Lys Ala Leu 
225                 230                 235                 240 


Glu Arg Ser Asp Lys Tyr Ile Glu Glu Leu Glu Ser Gln Val Ala Gln 
                245                 250                 255     


Leu Lys Asn Ser Ser Glu Glu Lys Glu Ala Met Asn Ser Ile Cys Gln 
            260                 265                 270         


Thr Ala Leu Ser Ala Asp Gly Lys Gly Ser Lys Gly Ser Glu Glu Asp 
        275                 280                 285             


Val Val Ser Lys Asn Gln Gly Asp Ser Ala Arg Lys Gln Pro Gly Ser 
    290                 295                 300                 


Ser Thr Ser Ser Ser Ser His Leu Ala Lys Pro Ser Ser Ser Arg Leu 
305                 310                 315                 320 


Cys Asp Thr Ser Ser Ala Arg Gln Glu Ser Thr Ser Lys Ala Asp Leu 
                325                 330                 335     


Asn Cys Ser Lys Asn Lys Asp Leu Tyr Gln Glu Gln Val Glu Val Met 
            340                 345                 350         


Leu Asp Val Thr Asp Thr Ser Met Asp Thr Tyr Leu Glu Arg Glu Trp 
        355                 360                 365             


Gly Asn Lys Pro Ser Asp Cys Val Pro Tyr Lys Asp Glu Glu Leu Tyr 
    370                 375                 380                 


Asp Leu Pro Ala Pro Cys Thr Pro Leu Ser Leu Ser Cys Leu Gln Leu 
385                 390                 395                 400 


Ser Thr Pro Glu Asn Arg Glu Ser Ser Val Val Gln Ala Gly Gly Ser 
                405                 410                 415     


Lys Lys His Ser Asn His Leu Arg Lys Leu Val Phe Asp Asp Phe Cys 
            420                 425                 430         


Asp Ser Ser Asn Val Ser Asn Lys Asp Ser Ser Glu Asp Asp Ile Ser 
        435                 440                 445             


Arg Ser Glu Asn Glu Lys Lys Ser Val Phe Phe Phe Pro Lys Asp Arg 
    450                 455                 460                 


Ile Leu Gly Leu Leu Phe His Lys Leu Cys Pro Lys Leu Arg Phe 
465                 470                 475                 


<210>  101
<211>  27
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  derived from human Obi1 protein

<400>  101

Lys Ser Glu Cys Phe Ser Ser Pro Lys Thr Gly Phe Trp Asp Cys Cys 
1               5                   10                  15      


Ser Thr Ser Tyr Ala Gln Asn Leu Asp Phe Glu 
            20                  25          


<210>  102
<211>  81
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  derived from human Obi1 gene

<400>  102
aaatcagaat gtttttcttc cccaaagaca ggattttggg actgttgttc cacaagctat       60

gcccaaaact tagattttga a                                                 81


<210>  103
<211>  79
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  derived from human mutated Obi1 gene

<400>  103
aaatcagtgt ttttcttccc caaagacagg attttgggac tgttgttcca caagctatgc       60

ccaaaactta gattttgaa                                                    79


<210>  104
<211>  25
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  derived from mutated Obi1 protein

<400>  104

Lys Ser Val Phe Phe Phe Pro Lys Asp Arg Ile Leu Gly Leu Leu Phe 
1               5                   10                  15      


His Lys Leu Cys Pro Lys Leu Arg Phe 
            20                  25  


<210>  105
<211>  1104
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  uclic acid coding for a dominant negative form of Obi1

<400>  105
atggagcaaa agctcatttc tgaagaggac ttgaatgaaa tggagcaaaa gctcatttct       60

gaagaggact tgaatgaaat ggagcaaaag ctcatttctg aagaggactt gaatgaaatg      120

gagcaaaagc tcatttctga agaggacttg aatgaaatgg agcaaaagct catttctgaa      180

gaggacttga atgaaatgga gagcttgggc gacctcacca tgtctctggc tctcaaactg      240

gctggactgg acatcggatc catggctcag accgtgcaga atgttacatt gtcgctcact      300

ctgcccatca cgtgccacat ttgcttgggg aaggtacgtc agcctgtcat atgcatcaac      360

aaccatgtat tttgttcgat ttgtattgat ttgtggttga agaataatag ccagtgtcca      420

gcttgcagag tccccatcac tcctgaaaat ccttgcaaag aaattatagg aggaacaagt      480

gaaagtgaac ctatgctaag ccatacggtc aggaagcatc ttcggaaaac tagacttgaa      540

ttactacaca aagaatatga ggacgaaata gattgtttac agaaagaagt agaagagctt      600

aagagtaaaa atctcagctt ggagtcacag atcaaaacta ttctggatcc tttaaccttg      660

gtgcagggca accaaaatga agacaaacat ctagtcacag ataatccaag taaaattaac      720

ccagaaactg tagcagagtg gaagaaaaaa ctcagaacag ctaatgaaat ctatgaaaaa      780

gtgaaagatg atgtggataa gctaaaggag gcaaataaaa aattgaaatt ggaaaatggt      840

ggtctggtga gggagaattt acgactgaag gctgaagttg ataacagatc acctcaaaag      900

tttggaaggt ttgcagttgc tgctcttcag tccaaagtag aacagtatga gcgtgaaacc      960

aatcgcctca agaaagccct ggaacgaagt gataagtata tagaggaact agaatctcaa     1020

gttgcacagc taaaaaattc aagtgaagag aaagaagcta tgaattccat ttgccagaca     1080

gcactttctg cagatggcaa ataa                                            1104


<210>  106
<211>  367
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  dominant negative form of OBI1

<400>  106

Met Glu Gln Lys Leu Ile Ser Glu Glu Asp Leu Asn Glu Met Glu Gln 
1               5                   10                  15      


Lys Leu Ile Ser Glu Glu Asp Leu Asn Glu Met Glu Gln Lys Leu Ile 
            20                  25                  30          


Ser Glu Glu Asp Leu Asn Glu Met Glu Gln Lys Leu Ile Ser Glu Glu 
        35                  40                  45              


Asp Leu Asn Glu Met Glu Gln Lys Leu Ile Ser Glu Glu Asp Leu Asn 
    50                  55                  60                  


Glu Met Glu Ser Leu Gly Asp Leu Thr Met Ser Leu Ala Leu Lys Leu 
65                  70                  75                  80  


Ala Gly Leu Asp Ile Gly Ser Met Ala Gln Thr Val Gln Asn Val Thr 
                85                  90                  95      


Leu Ser Leu Thr Leu Pro Ile Thr Cys His Ile Cys Leu Gly Lys Val 
            100                 105                 110         


Arg Gln Pro Val Ile Cys Ile Asn Asn His Val Phe Cys Ser Ile Cys 
        115                 120                 125             


Ile Asp Leu Trp Leu Lys Asn Asn Ser Gln Cys Pro Ala Cys Arg Val 
    130                 135                 140                 


Pro Ile Thr Pro Glu Asn Pro Cys Lys Glu Ile Ile Gly Gly Thr Ser 
145                 150                 155                 160 


Glu Ser Glu Pro Met Leu Ser His Thr Val Arg Lys His Leu Arg Lys 
                165                 170                 175     


Thr Arg Leu Glu Leu Leu His Lys Glu Tyr Glu Asp Glu Ile Asp Cys 
            180                 185                 190         


Leu Gln Lys Glu Val Glu Glu Leu Lys Ser Lys Asn Leu Ser Leu Glu 
        195                 200                 205             


Ser Gln Ile Lys Thr Ile Leu Asp Pro Leu Thr Leu Val Gln Gly Asn 
    210                 215                 220                 


Gln Asn Glu Asp Lys His Leu Val Thr Asp Asn Pro Ser Lys Ile Asn 
225                 230                 235                 240 


Pro Glu Thr Val Ala Glu Trp Lys Lys Lys Leu Arg Thr Ala Asn Glu 
                245                 250                 255     


Ile Tyr Glu Lys Val Lys Asp Asp Val Asp Lys Leu Lys Glu Ala Asn 
            260                 265                 270         


Lys Lys Leu Lys Leu Glu Asn Gly Gly Leu Val Arg Glu Asn Leu Arg 
        275                 280                 285             


Leu Lys Ala Glu Val Asp Asn Arg Ser Pro Gln Lys Phe Gly Arg Phe 
    290                 295                 300                 


Ala Val Ala Ala Leu Gln Ser Lys Val Glu Gln Tyr Glu Arg Glu Thr 
305                 310                 315                 320 


Asn Arg Leu Lys Lys Ala Leu Glu Arg Ser Asp Lys Tyr Ile Glu Glu 
                325                 330                 335     


Leu Glu Ser Gln Val Ala Gln Leu Lys Asn Ser Ser Glu Glu Lys Glu 
            340                 345                 350         


Ala Met Asn Ser Ile Cys Gln Thr Ala Leu Ser Ala Asp Gly Lys 
        355                 360                 365         


<210>  107
<211>  4352
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  vector pCS2 comprising Myc tag

<400>  107
cgccattctg cctggggacg tcggagcaag cttgatttag gtgacactat agaatacaag       60

ctacttgttc tttttgcagg atcccatcga tttaaagcta tggagcaaaa gctcatttct      120

gaagaggact tgaatgaaat ggagcaaaag ctcatttctg aagaggactt gaatgaaatg      180

gagcaaaagc tcatttctga agaggacttg aatgaaatgg agcaaaagct catttctgaa      240

gaggacttga atgaaatgga gcaaaagctc atttctgaag aggacttgaa tgaaatggag      300

agcttgggcg acctcaccat ggagcaaaag ctcatttctg aagaggactt gaattcaagg      360

cctctcgagc ctctagaact atagtgagtc gtattacgta gatccagaca tgataagata      420

cattgatgag tttggacaaa ccacaactag aatgcagtga aaaaaatgct ttatttgtga      480

aatttgtgat gctattgctt tatttgtaac cattataagc tgcaataaac aagttaacaa      540

caacaattgc attcatttta tgtttcaggt tcagggggag gtgtgggagg ttttttaatt      600

cgcggccgcg gcgccaatgc attgggcccg gtacccagct tttgttccct ttagtgaggg      660

ttaattgcgc gcttggcgta atcatggtca tagctgtttc ctgtgtgaaa ttgttatccg      720

ctcacaattc cacacaacat acgagccgga agcataaagt gtaaagcctg gggtgcctaa      780

tgagtgagct aactcacatt aattgcgttg cgctcactgc ccgctttcca gtcgggaaac      840

ctgtcgtgcc agctgcatta atgaatcggc caacgcgcgg ggagaggcgg tttgcgtatt      900

gggcgctctt ccgcttcctc gctcactgac tcgctgcgct cggtcgttcg gctgcggcga      960

gcggtatcag ctcactcaaa ggcggtaata cggttatcca cagaatcagg ggataacgca     1020

ggaaagaaca tgtgagcaaa aggccagcaa aaggccagga accgtaaaaa ggccgcgttg     1080

ctggcgtttt tccataggct ccgcccccct gacgagcatc acaaaaatcg acgctcaagt     1140

cagaggtggc gaaacccgac aggactataa agataccagg cgtttccccc tggaagctcc     1200

ctcgtgcgct ctcctgttcc gaccctgccg cttaccggat acctgtccgc ctttctccct     1260

tcgggaagcg tggcgctttc tcatagctca cgctgtaggt atctcagttc ggtgtaggtc     1320

gttcgctcca agctgggctg tgtgcacgaa ccccccgttc agcccgaccg ctgcgcctta     1380

tccggtaact atcgtcttga gtccaacccg gtaagacacg acttatcgcc actggcagca     1440

gccactggta acaggattag cagagcgagg tatgtaggcg gtgctacaga gttcttgaag     1500

tggtggccta actacggcta cactagaagg acagtatttg gtatctgcgc tctgctgaag     1560

ccagttacct tcggaaaaag agttggtagc tcttgatccg gcaaacaaac caccgctggt     1620

agcggtggtt tttttgtttg caagcagcag attacgcgca gaaaaaaagg atctcaagaa     1680

gatcctttga tcttttctac ggggtctgac gctcagtgga acgaaaactc acgttaaggg     1740

attttggtca tgagattatc aaaaaggatc ttcacctaga tccttttaaa ttaaaaatga     1800

agttttaaat caatctaaag tatatatgag taaacttggt ctgacagtta ccaatgctta     1860

atcagtgagg cacctatctc agcgatctgt ctatttcgtt catccatagt tgcctgactc     1920

cccgtcgtgt agataactac gatacgggag ggcttaccat ctggccccag tgctgcaatg     1980

ataccgcgag acccacgctc accggctcca gatttatcag caataaacca gccagccgga     2040

agggccgagc gcagaagtgg tcctgcaact ttatccgcct ccatccagtc tattaattgt     2100

tgccgggaag ctagagtaag tagttcgcca gttaatagtt tgcgcaacgt tgttgccatt     2160

gctacaggca tcgtggtgtc acgctcgtcg tttggtatgg cttcattcag ctccggttcc     2220

caacgatcaa ggcgagttac atgatccccc atgttgtgca aaaaagcggt tagctccttc     2280

ggtcctccga tcgttgtcag aagtaagttg gccgcagtgt tatcactcat ggttatggca     2340

gcactgcata attctcttac tgtcatgcca tccgtaagat gcttttctgt gactggtgag     2400

tactcaacca agtcattctg agaatagtgt atgcggcgac cgagttgctc ttgcccggcg     2460

tcaatacggg ataataccgc gccacatagc agaactttaa aagtgctcat cattggaaaa     2520

cgttcttcgg ggcgaaaact ctcaaggatc ttaccgctgt tgagatccag ttcgatgtaa     2580

cccactcgtg cacccaactg atcttcagca tcttttactt tcaccagcgt ttctgggtga     2640

gcaaaaacag gaaggcaaaa tgccgcaaaa aagggaataa gggcgacacg gaaatgttga     2700

atactcatac tcttcctttt tcaatattat tgaagcattt atcagggtta ttgtctcatg     2760

agcggataca tatttgaatg tatttagaaa aataaacaaa taggggttcc gcgcacattt     2820

ccccgaaaag tgccacctaa attgtaagcg ttaatatttt gttaaaattc gcgttaaatt     2880

tttgttaaat cagctcattt tttaaccaat aggccgaaat cggcaaaatc ccttataaat     2940

caaaagaata gaccgagata gggttgagtg ttgttccagt ttggaacaag agtccactat     3000

taaagaacgt ggactccaac gtcaaagggc gaaaaaccgt ctatcagggc gatggcccac     3060

tacgtgaacc atcaccctaa tcaagttttt tggggtcgag gtgccgtaaa gcactaaatc     3120

ggaaccctaa agggagcccc cgatttagag cttgacgggg aaagccggcg aacgtggcga     3180

gaaaggaagg gaagaaagcg aaaggagcgg gcgctagggc gctggcaagt gtagcggtca     3240

cgctgcgcgt aaccaccaca cccgccgcgc ttaatgcgcc gctacagggc gcgtcccatt     3300

cgccattcag gctgcgcaac tgttgggaag ggcgatcggt gcgggcctct tcgctattac     3360

gccagtcgac catagccaat tcaatatggc gtatatggac tcatgccaat tcaatatggt     3420

ggatctggac ctgtgccaat tcaatatggc gtatatggac tcgtgccaat tcaatatggt     3480

ggatctggac cccagccaat tcaatatggc ggacttggca ccatgccaat tcaatatggc     3540

ggacttggca ctgtgccaac tggggagggg tctacttggc acggtgccaa gtttgaggag     3600

gggtcttggc cctgtgccaa gtccgccata ttgaattggc atggtgccaa taatggcggc     3660

catattggct atatgccagg atcaatatat aggcaatatc caatatggcc ctatgccaat     3720

atggctattg gccaggttca atactatgta ttggccctat gccatatagt attccatata     3780

tgggttttcc tattgacgta gatagcccct cccaatgggc ggtcccatat accatatatg     3840

gggcttccta ataccgccca tagccactcc cccattgacg tcaatggtct ctatatatgg     3900

tctttcctat tgacgtcata tgggcggtcc tattgacgta tatggcgcct cccccattga     3960

cgtcaattac ggtaaatggc ccgcctggct caatgcccat tgacgtcaat aggaccaccc     4020

accattgacg tcaatgggat ggctcattgc ccattcatat ccgttctcac gccccctatt     4080

gacgtcaatg acggtaaatg gcccacttgg cagtacatca atatctatta atagtaactt     4140

ggcaagtaca ttactattgg aaggacgcca gggtacattg gcagtactcc cattgacgtc     4200

aatggcggta aatggcccgc gatggctgcc aagtacatcc ccattgacgt caatggggag     4260

gggcaatgac gcaaatgggc gttccattga cgtaaatggg cggtaggcgt gcctaatggg     4320

aggtctatat aagcaatgct cgtttaggga ac                                   4352


<210>  108
<211>  52
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  derived from NES of PKI

<400>  108
catgtctctg gctctcaaac tggctggact ggacatcgga tccatggtct tg               52


<210>  109
<211>  52
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  derived from NES of PKI

<400>  109
aattcaagac catggatccg atgtccagtc cagccagttt gagagccaga ga               52


