                         SEQUENCE LISTING

<110>  Fundaci Hospital Universitari Vall d'Hebron - Institut de 
       Recerca
 
<120>  Sex Hormone-Binding globulin for use as a medicament

<130>  P2659PC00

<150>  EP13382202
<151>  2013-05-30

<160>  34    

<170>  PatentIn version 3.5

<210>  1
<211>  402
<212>  PRT
<213>  Homo sapiens

<400>  1

Met Glu Ser Arg Gly Pro Leu Ala Thr Ser Arg Leu Leu Leu Leu Leu 
1               5                   10                  15      


Leu Leu Leu Leu Leu Arg His Thr Arg Gln Gly Trp Ala Leu Arg Pro 
            20                  25                  30          


Val Leu Pro Thr Gln Ser Ala His Asp Pro Pro Ala Val His Leu Ser 
        35                  40                  45              


Asn Gly Pro Gly Gln Glu Pro Ile Ala Val Met Thr Phe Asp Leu Thr 
    50                  55                  60                  


Lys Ile Thr Lys Thr Ser Ser Ser Phe Glu Val Arg Thr Trp Asp Pro 
65                  70                  75                  80  


Glu Gly Val Ile Phe Tyr Gly Asp Thr Asn Pro Lys Asp Asp Trp Phe 
                85                  90                  95      


Met Leu Gly Leu Arg Asp Gly Arg Pro Glu Ile Gln Leu His Asn His 
            100                 105                 110         


Trp Ala Gln Leu Thr Val Gly Ala Gly Pro Arg Leu Asp Asp Gly Arg 
        115                 120                 125             


Trp His Gln Val Glu Val Lys Met Glu Gly Asp Ser Val Leu Leu Glu 
    130                 135                 140                 


Val Asp Gly Glu Glu Val Leu Arg Leu Arg Gln Val Ser Gly Pro Leu 
145                 150                 155                 160 


Thr Ser Lys Arg His Pro Ile Met Arg Ile Ala Leu Gly Gly Leu Leu 
                165                 170                 175     


Phe Pro Ala Ser Asn Leu Arg Leu Pro Leu Val Pro Ala Leu Asp Gly 
            180                 185                 190         


Cys Leu Arg Arg Asp Ser Trp Leu Asp Lys Gln Ala Glu Ile Ser Ala 
        195                 200                 205             


Ser Ala Pro Thr Ser Leu Arg Ser Cys Asp Val Glu Ser Asn Pro Gly 
    210                 215                 220                 


Ile Phe Leu Pro Pro Gly Thr Gln Ala Glu Phe Asn Leu Arg Asp Ile 
225                 230                 235                 240 


Pro Gln Pro His Ala Glu Pro Trp Ala Phe Ser Leu Asp Leu Gly Leu 
                245                 250                 255     


Lys Gln Ala Ala Gly Ser Gly His Leu Leu Ala Leu Gly Thr Pro Glu 
            260                 265                 270         


Asn Pro Ser Trp Leu Ser Leu His Leu Gln Asp Gln Lys Val Val Leu 
        275                 280                 285             


Ser Ser Gly Ser Gly Pro Gly Leu Asp Leu Pro Leu Val Leu Gly Leu 
    290                 295                 300                 


Pro Leu Gln Leu Lys Leu Ser Met Ser Arg Val Val Leu Ser Gln Gly 
305                 310                 315                 320 


Ser Lys Met Lys Ala Leu Ala Leu Pro Pro Leu Gly Leu Ala Pro Leu 
                325                 330                 335     


Leu Asn Leu Trp Ala Lys Pro Gln Gly Arg Leu Phe Leu Gly Ala Leu 
            340                 345                 350         


Pro Gly Glu Asp Ser Ser Thr Ser Phe Cys Leu Asn Gly Leu Trp Ala 
        355                 360                 365             


Gln Gly Gln Arg Leu Asp Val Asp Gln Ala Leu Asn Arg Ser His Glu 
    370                 375                 380                 


Ile Trp Thr His Ser Cys Pro Gln Ser Pro Gly Asn Gly Thr Asp Ala 
385                 390                 395                 400 


Ser His 
        


<210>  2
<211>  288
<212>  PRT
<213>  Homo sapiens

<400>  2

Pro Arg Phe Lys Gly Ser Pro Ala Val Leu Phe Lys Leu Thr Tyr Ala 
1               5                   10                  15      


Val Ile Thr Cys Phe Ser Leu Arg Leu Thr His Pro Pro Arg Pro Trp 
            20                  25                  30          


Ser Ala His Asp Pro Pro Ala Val His Leu Ser Asn Gly Pro Gly Gln 
        35                  40                  45              


Glu Pro Ile Ala Val Met Thr Phe Asp Leu Thr Lys Ile Thr Lys Thr 
    50                  55                  60                  


Ser Ser Ser Phe Glu Val Arg Thr Trp Asp Pro Glu Gly Val Ile Phe 
65                  70                  75                  80  


Tyr Gly Asp Thr Asn Pro Lys Asp Asp Trp Phe Met Leu Gly Leu Arg 
                85                  90                  95      


Asp Gly Arg Pro Glu Ile Gln Leu His Asn His Trp Ala Gln Leu Thr 
            100                 105                 110         


Val Gly Ala Gly Pro Arg Leu Asp Asp Gly Arg Trp His Gln Val Glu 
        115                 120                 125             


Val Lys Met Glu Gly Asp Ser Val Leu Leu Glu Val Asp Gly Glu Glu 
    130                 135                 140                 


Val Leu Arg Leu Arg Gln Val Ser Gly Pro Leu Thr Ser Lys Arg His 
145                 150                 155                 160 


Pro Ile Met Arg Ile Ala Leu Gly Gly Leu Leu Phe Pro Ala Ser Asn 
                165                 170                 175     


Leu Arg Leu Pro Leu Val Pro Ala Leu Asp Gly Cys Leu Arg Arg Asp 
            180                 185                 190         


Ser Trp Leu Asp Lys Gln Ala Glu Ile Ser Ala Ser Ala Pro Thr Ser 
        195                 200                 205             


Leu Arg Ser Cys Asp Val Glu Ser Asn Pro Gly Ile Phe Leu Pro Pro 
    210                 215                 220                 


Gly Thr Gln Ala Glu Phe Asn Leu Arg Asp Ile Pro Gln Pro His Ala 
225                 230                 235                 240 


Glu Pro Trp Ala Phe Ser Leu Asp Leu Gly Leu Lys Gln Ala Ala Gly 
                245                 250                 255     


Ser Gly His Leu Leu Ala Leu Gly Thr Pro Glu Asn Pro Ser Trp Leu 
            260                 265                 270         


Ser Leu His Leu Gln Asp Gln Glu Lys Thr Leu Pro Pro Leu Phe Ala 
        275                 280                 285             


<210>  3
<211>  293
<212>  PRT
<213>  Homo sapiens

<400>  3

Met Glu Ser Arg Gly Pro Leu Ala Thr Ser Arg Leu Leu Leu Leu Leu 
1               5                   10                  15      


Leu Leu Leu Leu Leu Arg His Thr Arg Gln Gly Trp Ala Leu Arg Pro 
            20                  25                  30          


Val Leu Pro Thr Gln Ser Ala His Asp Pro Pro Ala Val His Leu Ser 
        35                  40                  45              


Asn Gly Pro Gly Gln Glu Pro Ile Ala Val Met Thr Phe Asp Leu Thr 
    50                  55                  60                  


Lys Ile Thr Lys Thr Ser Ser Ser Phe Glu Val Arg Thr Trp Asp Pro 
65                  70                  75                  80  


Glu Gly Val Ile Phe Tyr Gly Asp Thr Asn Pro Lys Asp Asp Trp Phe 
                85                  90                  95      


Met Leu Gly Leu Arg Asp Gly Arg Pro Glu Ile Gln Leu His Asn His 
            100                 105                 110         


Trp Ala Gln Leu Thr Val Gly Ala Gly Pro Arg Leu Asp Asp Gly Arg 
        115                 120                 125             


Trp His Gln Val Glu Val Lys Met Glu Gly Asp Ser Val Leu Leu Glu 
    130                 135                 140                 


Val Asp Gly Glu Glu Val Leu Arg Leu Arg Gln Val Ser Gly Pro Leu 
145                 150                 155                 160 


Thr Ser Lys Arg His Pro Ile Met Arg Ile Ala Leu Gly Gly Leu Leu 
                165                 170                 175     


Phe Pro Ala Ser Asn Leu Arg Leu Pro Leu Val Pro Ala Leu Asp Gly 
            180                 185                 190         


Cys Leu Arg Arg Asp Ser Trp Leu Asp Lys Gln Ala Glu Ile Ser Ala 
        195                 200                 205             


Ser Ala Pro Thr Ser Leu Arg Ser Cys Asp Val Glu Ser Asn Pro Gly 
    210                 215                 220                 


Ile Phe Leu Pro Pro Gly Thr Gln Ala Glu Phe Asn Leu Arg Asp Ile 
225                 230                 235                 240 


Pro Gln Pro His Ala Glu Pro Trp Ala Phe Ser Leu Asp Leu Gly Leu 
                245                 250                 255     


Lys Gln Ala Ala Gly Ser Gly His Leu Leu Ala Leu Gly Thr Pro Glu 
            260                 265                 270         


Asn Pro Ser Trp Leu Ser Leu His Leu Gln Asp Gln Glu Lys Thr Leu 
        275                 280                 285             


Pro Pro Leu Phe Ala 
    290             


<210>  4
<211>  287
<212>  PRT
<213>  Homo sapiens

<400>  4

Met Glu Ser Arg Gly Pro Leu Ala Thr Ser Arg Leu Leu Leu Leu Leu 
1               5                   10                  15      


Leu Leu Leu Leu Leu Arg His Thr Arg Gln Gly Trp Ala Leu Arg Pro 
            20                  25                  30          


Val Leu Pro Thr Gln Ser Ala His Asp Pro Pro Ala Val His Leu Ser 
        35                  40                  45              


Asn Gly Pro Gly Gln Glu Pro Ile Ala Val Met Thr Phe Asp Leu Thr 
    50                  55                  60                  


Lys Ile Thr Lys Thr Ser Ser Ser Phe Glu Val Arg Thr Trp Asp Pro 
65                  70                  75                  80  


Glu Gly Val Ile Phe Tyr Gly Asp Thr Asn Pro Lys Asp Asp Trp Phe 
                85                  90                  95      


Met Leu Gly Leu Arg Asp Gly Arg Pro Glu Ile Gln Leu His Asn His 
            100                 105                 110         


Trp Ala Gln Leu Thr Val Gly Ala Gly Pro Arg Leu Asp Asp Gly Arg 
        115                 120                 125             


Trp His Gln Val Glu Val Lys Met Glu Gly Asp Ser Val Leu Leu Glu 
    130                 135                 140                 


Val Asp Gly Glu Glu Val Leu Arg Leu Arg Gln Val Ser Gly Pro Leu 
145                 150                 155                 160 


Thr Ser Lys Arg His Pro Ile Met Arg Ile Ala Leu Gly Gly Leu Leu 
                165                 170                 175     


Phe Pro Ala Ser Asn Leu Arg Leu Pro Leu Val Pro Ala Leu Asp Gly 
            180                 185                 190         


Cys Leu Arg Arg Asp Ser Trp Leu Asp Lys Gln Ala Glu Ile Ser Ala 
        195                 200                 205             


Ser Ala Pro Thr Ser Leu Arg Ser Cys Asp Val Glu Ser Asn Pro Gly 
    210                 215                 220                 


Ile Phe Leu Pro Pro Gly Thr Gln Ala Glu Phe Asn Leu Arg Gly Glu 
225                 230                 235                 240 


Asp Ser Ser Thr Ser Phe Cys Leu Asn Gly Leu Trp Ala Gln Gly Gln 
                245                 250                 255     


Arg Leu Asp Val Asp Gln Ala Leu Asn Arg Ser His Glu Ile Trp Thr 
            260                 265                 270         


His Ser Cys Pro Gln Ser Pro Gly Asn Gly Thr Asp Ala Ser His 
        275                 280                 285         


<210>  5
<211>  384
<212>  PRT
<213>  Homo sapiens

<400>  5

Met Glu Ser Arg Gly Pro Leu Ala Thr Ser Arg Leu Leu Leu Leu Leu 
1               5                   10                  15      


Leu Leu Leu Leu Leu Arg His Thr Arg Gln Gly Trp Ala Leu Arg Pro 
            20                  25                  30          


Val Leu Pro Thr Gln Ser Ala His Asp Pro Pro Ala Val His Leu Ser 
        35                  40                  45              


Asn Gly Pro Gly Gln Glu Pro Ile Ala Val Met Thr Phe Asp Leu Thr 
    50                  55                  60                  


Lys Ile Thr Lys Thr Ser Ser Ser Phe Glu Val Arg Thr Trp Asp Pro 
65                  70                  75                  80  


Glu Gly Val Ile Phe Tyr Gly Asp Thr Asn Pro Lys Asp Asp Trp Phe 
                85                  90                  95      


Met Leu Gly Leu Arg Asp Gly Arg Pro Glu Ile Gln Leu His Asn His 
            100                 105                 110         


Trp Ala Gln Leu Thr Val Gly Ala Gly Pro Arg Leu Asp Asp Gly Arg 
        115                 120                 125             


Trp His Gln Val Glu Val Lys Met Glu Gly Asp Ser Val Leu Leu Glu 
    130                 135                 140                 


Val Asp Gly Glu Glu Val Leu Arg Leu Arg Gln Val Ser Gly Pro Leu 
145                 150                 155                 160 


Thr Ser Lys Arg His Pro Ile Met Arg Ile Ala Leu Gly Gly Leu Leu 
                165                 170                 175     


Phe Pro Ala Ser Asn Leu Arg Leu Pro Ala Glu Ile Ser Ala Ser Ala 
            180                 185                 190         


Pro Thr Ser Leu Arg Ser Cys Asp Val Glu Ser Asn Pro Gly Ile Phe 
        195                 200                 205             


Leu Pro Pro Gly Thr Gln Ala Glu Phe Asn Leu Arg Asp Ile Pro Gln 
    210                 215                 220                 


Pro His Ala Glu Pro Trp Ala Phe Ser Leu Asp Leu Gly Leu Lys Gln 
225                 230                 235                 240 


Ala Ala Gly Ser Gly His Leu Leu Ala Leu Gly Thr Pro Glu Asn Pro 
                245                 250                 255     


Ser Trp Leu Ser Leu His Leu Gln Asp Gln Lys Val Val Leu Ser Ser 
            260                 265                 270         


Gly Ser Gly Pro Gly Leu Asp Leu Pro Leu Val Leu Gly Leu Pro Leu 
        275                 280                 285             


Gln Leu Lys Leu Ser Met Ser Arg Val Val Leu Ser Gln Gly Ser Lys 
    290                 295                 300                 


Met Lys Ala Leu Ala Leu Pro Pro Leu Gly Leu Ala Pro Leu Leu Asn 
305                 310                 315                 320 


Leu Trp Ala Lys Pro Gln Gly Arg Leu Phe Leu Gly Ala Leu Pro Gly 
                325                 330                 335     


Glu Asp Ser Ser Thr Ser Phe Cys Leu Asn Gly Leu Trp Ala Gln Gly 
            340                 345                 350         


Gln Arg Leu Asp Val Asp Gln Ala Leu Asn Arg Ser His Glu Ile Trp 
        355                 360                 365             


Thr His Ser Cys Pro Gln Ser Pro Gly Asn Gly Thr Asp Ala Ser His 
    370                 375                 380                 


<210>  6
<211>  403
<212>  PRT
<213>  Mus musculus

<400>  6

Met Glu Lys Arg Asp Ser Val Ala Leu His Trp Arg Leu Leu Leu Leu 
1               5                   10                  15      


Leu Leu Leu Leu Met Pro Pro Pro Thr His Gln Gly Arg Ala Leu Arg 
            20                  25                  30          


His Ile Asp Pro Ile Gln Ser Ala Gln Asp Pro Pro Ala Lys Tyr Leu 
        35                  40                  45              


Ser Asn Gly Pro Gly Gln Glu Pro Val Met Val Met Thr Ile Asp Leu 
    50                  55                  60                  


Thr Lys Ile Ser Lys Pro His Ser Ser Phe Glu Phe Arg Thr Trp Asp 
65                  70                  75                  80  


Pro Glu Gly Val Ile Phe Tyr Gly Asp Thr Asn Thr Glu Asp Asp Trp 
                85                  90                  95      


Phe Leu Leu Gly Leu Arg Ala Gly Gln Leu Glu Ile Gln Leu His Asn 
            100                 105                 110         


Ala Trp Ala Arg Leu Thr Val Gly Phe Gly Pro Arg Leu Asp Asp Gly 
        115                 120                 125             


Arg Trp His Pro Val Glu Leu Lys Met Asn Gly Asp Ser Leu Leu Leu 
    130                 135                 140                 


Trp Val Asp Gly Lys Glu Met Leu Cys Leu Arg Gln Ile Ser Ala Ser 
145                 150                 155                 160 


Leu Ala Asp His Ser Gln Arg Ser Met Arg Ile Ala Leu Gly Gly Leu 
                165                 170                 175     


Leu Leu Pro Thr Ser Lys Leu Arg Phe Pro Leu Val Pro Ala Leu Asp 
            180                 185                 190         


Gly Cys Ile Arg Arg Asp Ile Trp Leu Gly His Gln Ala Gln Leu Ser 
        195                 200                 205             


Ala Ser Pro Arg Thr Ser Leu Gly Asn Cys Asp Val Asp Leu Gln Pro 
    210                 215                 220                 


Gly Leu Phe Phe Pro Pro Gly Thr His Ala Glu Phe Ser Leu Gln Asp 
225                 230                 235                 240 


Ile Pro Gln Pro His Ala Asp Pro Trp Thr Phe Ser Leu Glu Leu Gly 
                245                 250                 255     


Phe Lys Leu Val Asp Gly Ser Gly Gln Leu Leu Ala Leu Gly Thr Gly 
            260                 265                 270         


Thr Asn Ser Ser Trp Leu Asn Ile His Leu Gln Asn Gln Ser Val Val 
        275                 280                 285             


Leu Ser Ser Glu Ala Glu Pro Lys Val Val Leu Pro Leu Asp Val Gly 
    290                 295                 300                 


Leu Pro Leu Gln Leu Thr Leu Asp Arg Val Lys Val Val Leu Ser Gln 
305                 310                 315                 320 


Gly Pro Lys Met Glu Val Leu Ser Met Ser Leu Leu Arg Pro Ala Ser 
                325                 330                 335     


Leu Trp Arg Leu Trp Ser His Pro Gln Gly His Leu Ser Leu Gly Ala 
            340                 345                 350         


Leu Pro Gly Glu Ser Ser Ser Ala Ser Phe Cys Leu Ser Asp Phe Trp 
        355                 360                 365             


Val Gln Gly Gln Arg Leu Asp Ile Asp Gln Ala Leu Ser Arg Ser Gln 
    370                 375                 380                 


Asp Ile Trp Thr His Ser Cys Pro Gln Arg Pro Ser Asn Asp Thr Arg 
385                 390                 395                 400 


Thr Ser His 
            


<210>  7
<211>  21
<212>  DNA
<213>  Artificial

<220>
<223>  Forward primer

<400>  7
gccattggta ttggggctta c                                                 21


<210>  8
<211>  20
<212>  DNA
<213>  Artificial

<220>
<223>  Reverse primer

<400>  8
cccgaccaag gactttgttg                                                   20


<210>  9
<211>  20
<212>  DNA
<213>  Artificial

<220>
<223>  Forward primer

<400>  9
ggcatcattg ggcactcctt                                                   20


<210>  10
<211>  20
<212>  DNA
<213>  Artificial

<220>
<223>  Reverse primer

<400>  10
gctgcaagca cagcctctct                                                   20


<210>  11
<211>  25
<212>  DNA
<213>  Artificial

<220>
<223>  Forward primer

<400>  11
catcttctca aaattcgagt gacaa                                             25


<210>  12
<211>  23
<212>  DNA
<213>  Artificial

<220>
<223>  Reverse primer

<400>  12
tgggagtaga caaggtacaa ccc                                               23


<210>  13
<211>  25
<212>  DNA
<213>  Artificial

<220>
<223>  Forward primer

<400>  13
caaccaacaa gtgatattct ccatg                                             25


<210>  14
<211>  21
<212>  DNA
<213>  Artificial

<220>
<223>  Reverse primer

<400>  14
gatccacact ctccagctgc a                                                 21


<210>  15
<211>  23
<212>  DNA
<213>  Artificial

<220>
<223>  Forward primer

<400>  15
ctgcaagaga cttccatcca gtt                                               23


<210>  16
<211>  19
<212>  DNA
<213>  Artificial

<220>
<223>  Reverse primer

<400>  16
gaagtaggga aggccgtgg                                                    19


<210>  17
<211>  20
<212>  DNA
<213>  Artificial

<220>
<223>  Forward primer

<400>  17
agggttcgat tccggagagg                                                   20


<210>  18
<211>  22
<212>  DNA
<213>  Artificial

<220>
<223>  Reverse primer

<400>  18
caactttaat atacgctatt gg                                                22


<210>  19
<211>  21
<212>  DNA
<213>  Artificial

<220>
<223>  Forward primer

<400>  19
gctgattatg gagagcagag g                                                 21


<210>  20
<211>  20
<212>  DNA
<213>  Artificial

<220>
<223>  Reverse primer

<400>  20
ggtcatgaca gcgataggct                                                   20


<210>  21
<211>  21
<212>  DNA
<213>  Artificial

<220>
<223>  Forward primer

<400>  21
gtggcgagtc cttatgacac g                                                 21


<210>  22
<211>  21
<212>  DNA
<213>  Artificial

<220>
<223>  Reverse primer

<400>  22
cacattgtcg gctaaacctg c                                                 21


<210>  23
<211>  21
<212>  DNA
<213>  Artificial

<220>
<223>  Forward primer

<400>  23
tcttaactgc cggatccaca a                                                 21


<210>  24
<211>  19
<212>  DNA
<213>  Artificial

<220>
<223>  Reverse primer

<400>  24
gcccaaacct gatggcatt                                                    19


<210>  25
<211>  22
<212>  DNA
<213>  Artificial

<220>
<223>  Forward primer

<400>  25
agccgcttat atgtatcgct ca                                                22


<210>  26
<211>  23
<212>  DNA
<213>  Artificial

<220>
<223>  Reverse primer

<400>  26
tgccgtcata atgattctgt tgg                                               23


<210>  27
<211>  23
<212>  DNA
<213>  Artificial

<220>
<223>  Forward primer

<400>  27
ctagacctca ggcctgtgaa tgc                                               23


<210>  28
<211>  20
<212>  DNA
<213>  Artificial

<220>
<223>  Reverse primer

<400>  28
ggcaggcagc cttgcgtgtg                                                   20


<210>  29
<211>  20
<212>  DNA
<213>  Artificial

<220>
<223>  Forward primer

<400>  29
gctcctcctt ctgctgctgc                                                   20


<210>  30
<211>  20
<212>  DNA
<213>  Artificial

<220>
<223>  Reverse primer

<400>  30
ggaagagctt gagacaggcc                                                   20


<210>  31
<211>  22
<212>  DNA
<213>  Artificial

<220>
<223>  Forward primer

<400>  31
ctgggagatt ctcctattga cc                                                22


<210>  32
<211>  24
<212>  DNA
<213>  Artificial

<220>
<223>  Reverse primer

<400>  32
cactttgatt gcactttggt actc                                              24


<210>  33
<211>  21
<212>  DNA
<213>  Artificial

<220>
<223>  Forward primer

<400>  33
taacgaacga gactctggca t                                                 21


<210>  34
<211>  22
<212>  DNA
<213>  Artificial

<220>
<223>  Reverse primer

<400>  34
cggacatcta agggcatcac ag                                                22


