                         SEQUENCE LISTING

<110>  VIB VZW
       LIFE SCIENCES RESEARCH PARTNERS VZW
       KATHOLIEKE UNIVERSITEIT LEUVEN, K.U.LEUVEN R&D
 
<120>  Single domain antibodies against SOD1 and their use in medicine

<130>  WR/NSOD/456

<150>  EP 13169476.2
<151>  2013-05-28

<160>  28    

<170>  PatentIn version 3.5

<210>  1
<211>  130
<212>  PRT
<213>  Camelus dromedarius

<400>  1

Gln Val Gln Leu Gln Glu Ser Gly Gly Gly Ser Val Gln Ala Gly Gly 
1               5                   10                  15      


Ser Leu Arg Leu Ala Cys Val Ala Ser Gly Gly Asp Thr Arg Pro Tyr 
            20                  25                  30          


Ile Thr Tyr Trp Met Gly Trp Tyr Arg Gln Ala Pro Gly Lys Glu Arg 
        35                  40                  45              


Glu Gly Val Ala Thr Ile Tyr Thr Gly Gly Ser Gly Thr Tyr Tyr Ser 
    50                  55                  60                  


Asp Ser Val Glu Gly Arg Phe Thr Ile Ser Gln Asp Lys Ala Gln Arg 
65                  70                  75                  80  


Thr Val Tyr Leu Gln Met Asn Asp Leu Lys Pro Glu Asp Thr Ala Met 
                85                  90                  95      


Tyr Tyr Cys Ala Ala Gly Asn Gly Ala Leu Pro Pro Gly Arg Arg Leu 
            100                 105                 110         


Ser Pro Gln Asn Met Asp Thr Trp Gly Pro Gly Thr Gln Val Thr Val 
        115                 120                 125             


Ser Ser 
    130 


<210>  2
<211>  117
<212>  PRT
<213>  Vicugna pacos

<400>  2

Gln Val Gln Leu Gln Glu Ser Gly Gly Gly Leu Val Gln Pro Gly Gly 
1               5                   10                  15      


Ser Leu Arg Leu Ser Cys Arg Ala Ser Glu Thr Leu Phe Ser Leu Tyr 
            20                  25                  30          


Ala Met Gly Trp Tyr Arg Gln Ala Pro Gly Lys Gln Pro Glu Leu Ile 
        35                  40                  45              


Ala Thr Ile Ser Gly Gly Gly Glu Gly Thr Gly Asn Tyr Ala Asp Pro 
    50                  55                  60                  


Val Lys Gly Arg Phe Thr Ile Ser Arg Asn Asn Ala Asp Asn Met Val 
65                  70                  75                  80  


Phe Leu Gln Met Asn Asn Leu Lys Pro Glu Asp Thr Ala Val Tyr Tyr 
                85                  90                  95      


Cys Asn Val Tyr Gly Thr Asn Leu Ala Pro Trp Gly Gln Gly Thr Gln 
            100                 105                 110         


Val Thr Val Ser Ser 
        115         


<210>  3
<211>  127
<212>  PRT
<213>  Camelus dromedarius

<400>  3

Gln Val Gln Leu Gln Glu Ser Gly Gly Gly Leu Val Gln Ala Gly Gly 
1               5                   10                  15      


Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Leu Pro Tyr Arg Thr Val 
            20                  25                  30          


Phe Met Gly Trp Phe Arg Gln Gly Pro Gly Lys Glu Arg Glu Gly Val 
        35                  40                  45              


Ala Val Ile Asn Ala Asp Gly Val Ser Thr Tyr Tyr Ala Asp Ser Val 
    50                  55                  60                  


Lys Gly Arg Phe Thr Ile Ser Gln Asp Asn Ala Lys Asn Thr Val Tyr 
65                  70                  75                  80  


Leu Gln Met Asn Ser Leu Lys Pro Glu Asp Thr Ala Ile Tyr His Cys 
                85                  90                  95      


Ala Ala Asn His Phe Phe Asp Tyr Ser Arg Asp Pro Leu Ala Thr Ala 
            100                 105                 110         


Glu Tyr Asn Tyr Trp Gly Gln Gly Thr Gln Val Thr Val Ser Ser 
        115                 120                 125         


<210>  4
<211>  123
<212>  PRT
<213>  Camelus dromedarius

<400>  4

Gln Val Gln Leu Gln Glu Ser Gly Gly Gly Ser Val Gln Thr Gly Gly 
1               5                   10                  15      


Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Tyr Thr Phe Ser Ser Tyr 
            20                  25                  30          


Cys Met Gly Trp Phe Arg Gln Ala Pro Gly Lys Glu Arg Glu Leu Val 
        35                  40                  45              


Ser Thr Ile Ile Ser Asp Gly Ser Thr Tyr Tyr Ala Asp Ser Val Lys 
    50                  55                  60                  


Gly Arg Phe Thr Ile Ser Gln Asp Asn Ala Lys Asn Thr Val Tyr Leu 
65                  70                  75                  80  


Gln Met Asn Asn Leu Lys Ala Glu Asp Thr Ala Ile Tyr Tyr Cys Ala 
                85                  90                  95      


Ala Arg Ser Gly Gly Val Cys Ser Gly Arg Ala Ser Arg Tyr Asn Tyr 
            100                 105                 110         


Trp Gly Gln Gly Thr Gln Val Thr Val Ser Ser 
        115                 120             


<210>  5
<211>  127
<212>  PRT
<213>  Camelus dromedarius

<400>  5

Gln Val Gln Leu Gln Glu Ser Gly Gly Gly Ser Val Gln Ala Gly Gly 
1               5                   10                  15      


Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Leu Pro Tyr Arg Thr Val 
            20                  25                  30          


Phe Met Gly Trp Phe Arg Gln Gly Pro Gly Lys Glu Arg Glu Gly Val 
        35                  40                  45              


Ala Val Ile Asn Ala Asp Gly Val Ser Thr Tyr Tyr Ala Asp Ser Val 
    50                  55                  60                  


Lys Gly Arg Phe Thr Ile Ser Arg Asp Asn Ala Lys Asp Thr Val Tyr 
65                  70                  75                  80  


Leu Gln Met Asn Ser Leu Lys Pro Glu Asp Thr Ala Ile Tyr His Cys 
                85                  90                  95      


Ala Ala Asn His Phe Phe Asp Tyr Ser Arg Asp Pro Leu Ala Thr Ala 
            100                 105                 110         


Glu Tyr Asn Tyr Trp Gly Gln Gly Thr Gln Val Thr Val Ser Ser 
        115                 120                 125         


<210>  6
<211>  127
<212>  PRT
<213>  Camelus dromedarius

<400>  6

Gln Val Gln Leu Gln Glu Ser Gly Gly Gly Ser Val Gln Ala Gly Gly 
1               5                   10                  15      


Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Leu Pro Tyr Arg Thr Val 
            20                  25                  30          


Phe Met Gly Trp Phe Arg Gln Gly Pro Gly Lys Glu Arg Glu Gly Val 
        35                  40                  45              


Ala Val Ile Asn Ala Asp Gly Val Ser Thr Tyr Tyr Ala Asp Ser Val 
    50                  55                  60                  


Lys Gly Arg Phe Thr Ile Ser Gln Asp Asn Ala Lys Asn Thr Val Tyr 
65                  70                  75                  80  


Leu Gln Met Asn Ser Leu Lys Pro Glu Asp Thr Ala Ile Tyr His Cys 
                85                  90                  95      


Ala Ala Asn His Phe Phe Asp Tyr Ser Arg Asp Pro Leu Ala Thr Ala 
            100                 105                 110         


Glu Tyr Asn Tyr Trp Gly Gln Gly Thr Gln Val Thr Val Ser Ser 
        115                 120                 125         


<210>  7
<211>  127
<212>  PRT
<213>  Camelus dromedarius

<400>  7

Gln Val Gln Leu Gln Glu Ser Gly Gly Gly Ser Val Gln Ala Gly Gly 
1               5                   10                  15      


Ser Leu Arg Leu Ser Cys Ala Ala Pro Gly Leu Pro Tyr Arg Val Val 
            20                  25                  30          


Phe Met Gly Trp Phe Arg Gln Gly Pro Gly Lys Glu Arg Glu Gly Val 
        35                  40                  45              


Ala Val Ile Asn Ala Asp Gly Val Ser Thr Tyr Tyr Ala Asp Ser Val 
    50                  55                  60                  


Lys Gly Arg Phe Thr Ile Ser Gln Asp Asn Ala Lys Asn Thr Val Tyr 
65                  70                  75                  80  


Leu Gln Met Asn Ser Leu Lys Pro Glu Asp Thr Ala Ile Tyr Tyr Cys 
                85                  90                  95      


Ala Ala Asn His Phe Phe Asp Tyr Ser Arg Asp Pro Leu Ala Thr Ala 
            100                 105                 110         


Glu Tyr Asn Tyr Trp Gly Gln Gly Thr Gln Val Thr Val Ser Ser 
        115                 120                 125         


<210>  8
<211>  130
<212>  PRT
<213>  Camelus dromedarius

<400>  8

Gln Val Gln Leu Gln Glu Ser Gly Gly Gly Ser Val Gln Ala Gly Gly 
1               5                   10                  15      


Ser Leu Arg Leu Ala Cys Val Ala Ser Gly Gly Asp Thr Arg Pro Tyr 
            20                  25                  30          


Ile Thr Tyr Trp Met Gly Trp Tyr Arg Gln Ala Pro Gly Lys Glu Arg 
        35                  40                  45              


Glu Gly Val Ala Thr Ile Tyr Thr Gly Gly Ser Gly Thr Tyr Tyr Ser 
    50                  55                  60                  


Asp Ser Val Glu Gly Arg Phe Thr Ile Ser Gln Asp Lys Ala Gln Arg 
65                  70                  75                  80  


Thr Val Tyr Leu Gln Met Asn Asp Leu Lys Pro Glu Asp Thr Gly Met 
                85                  90                  95      


Tyr Tyr Cys Ala Ala Gly Asn Gly Ala Leu Pro Pro Gly Arg Arg Leu 
            100                 105                 110         


Ser Pro Gln Asn Met Asp Thr Trp Gly Pro Gly Thr Gln Val Thr Val 
        115                 120                 125             


Ser Ser 
    130 


<210>  9
<211>  117
<212>  PRT
<213>  Vicugna pacos

<400>  9

Gln Val Gln Leu Gln Glu Ser Gly Gly Gly Leu Val Gln Pro Gly Gly 
1               5                   10                  15      


Ser Leu Arg Leu Ser Cys Arg Ala Ser Glu Ser Leu Phe Ser Leu Tyr 
            20                  25                  30          


Ala Met Gly Trp Tyr Arg Gln Ala Pro Gly Lys Gln Pro Glu Leu Ile 
        35                  40                  45              


Ala Thr Ile Ser Gly Gly Gly Glu Gly Thr Gly Asn Tyr Ala Asp Pro 
    50                  55                  60                  


Val Lys Gly Arg Phe Thr Ile Ser Arg Asn Asn Ala Asn Asn Met Val 
65                  70                  75                  80  


Phe Leu Gln Met Asn Ser Leu Lys Pro Glu Asp Thr Ala Val Tyr Tyr 
                85                  90                  95      


Cys Asn Val Tyr Gly Thr Asn Leu Ala Pro Trp Gly Gln Gly Thr Gln 
            100                 105                 110         


Val Thr Val Ser Ser 
        115         


<210>  10
<211>  117
<212>  PRT
<213>  Vicugna pacos

<400>  10

Gln Val Gln Leu Gln Glu Ser Gly Gly Gly Leu Val Gln Pro Gly Gly 
1               5                   10                  15      


Ser Leu Arg Leu Ser Cys Arg Ala Ser Glu Thr Leu Phe Ser Leu Tyr 
            20                  25                  30          


Ala Met Gly Trp Tyr Arg Gln Ala Pro Gly Lys Gln Pro Glu Leu Ile 
        35                  40                  45              


Ala Thr Ile Ser Gly Gly Gly Glu Gly Thr Gly Asn Tyr Ala Asp Pro 
    50                  55                  60                  


Val Lys Gly Arg Phe Thr Ile Ser Arg Asn Asn Ala Asn Asn Met Val 
65                  70                  75                  80  


Phe Leu Gln Met Asn Asn Leu Lys Pro Glu Asp Thr Ala Val Tyr Tyr 
                85                  90                  95      


Cys Asn Val Tyr Gly Thr Asn Leu Ala Pro Trp Gly Gln Gly Thr Gln 
            100                 105                 110         


Val Thr Val Ser Ser 
        115         


<210>  11
<211>  117
<212>  PRT
<213>  Vicugna pacos

<400>  11

Gln Val Gln Leu Gln Glu Ser Gly Gly Gly Leu Val Gln Pro Gly Gly 
1               5                   10                  15      


Ser Leu Arg Leu Ser Cys Arg Val Ser Glu Ser Leu Phe Ser Leu Tyr 
            20                  25                  30          


Ala Met Gly Trp Tyr Arg Gln Ala Pro Gly Lys Gln Pro Glu Leu Ile 
        35                  40                  45              


Ala Thr Ile Ser Gly Gly Gly Glu Gly Thr Gly Asn Tyr Ala Asp Pro 
    50                  55                  60                  


Val Lys Gly Arg Phe Thr Ile Ser Arg Asn Asn Ala Asn Asn Thr Val 
65                  70                  75                  80  


Phe Leu Gln Met Asn Ser Leu Lys Pro Glu Asp Thr Ala Val Tyr Tyr 
                85                  90                  95      


Cys Asn Val Tyr Gly Thr Asn Leu Ala Pro Trp Gly Gln Gly Thr Gln 
            100                 105                 110         


Val Thr Val Ser Ser 
        115         


<210>  12
<211>  117
<212>  PRT
<213>  Vicugna pacos

<400>  12

Gln Val Gln Leu Gln Glu Ser Gly Gly Gly Leu Val Gln Pro Gly Gly 
1               5                   10                  15      


Ser Leu Arg Leu Ser Cys Arg Ala Ser Glu Ser Leu Phe Ser Leu Tyr 
            20                  25                  30          


Ala Met Gly Trp Tyr Arg Gln Ala Pro Gly Lys Gln Pro Glu Leu Ile 
        35                  40                  45              


Ala Thr Ile Ser Gly Gly Gly Glu Gly Thr Gly Asn Tyr Ala Asp Pro 
    50                  55                  60                  


Val Lys Gly Arg Phe Thr Ile Ser Arg Asn Asn Ala Asn Asn Thr Val 
65                  70                  75                  80  


Phe Leu Gln Met Asn Ser Leu Lys Pro Glu Asp Thr Ala Val Tyr Tyr 
                85                  90                  95      


Cys Asn Val Tyr Gly Thr Asn Leu Ala Pro Trp Gly Gln Gly Thr Gln 
            100                 105                 110         


Val Thr Val Ser Ser 
        115         


<210>  13
<211>  117
<212>  PRT
<213>  Vicugna pacos

<400>  13

Gln Val Gln Leu Gln Glu Ser Gly Gly Gly Leu Val Gln Pro Gly Gly 
1               5                   10                  15      


Ser Leu Arg Leu Ser Cys Ala Ala Ser Glu Thr Leu Phe Ser Leu Tyr 
            20                  25                  30          


Ala Met Gly Trp Tyr Arg Gln Ala Pro Gly Lys Gln Pro Glu Leu Ile 
        35                  40                  45              


Ala Thr Ile Ser Gly Gly Gly Glu Gly Thr Gly Asn Tyr Ala Asp Pro 
    50                  55                  60                  


Val Lys Gly Arg Phe Thr Ile Ser Arg Asn Asn Ala Asp Asn Met Val 
65                  70                  75                  80  


Phe Leu Gln Met Asn Asn Leu Lys Pro Glu Asp Thr Ala Val Tyr Tyr 
                85                  90                  95      


Cys Asn Val Tyr Gly Thr Asn Leu Ala Pro Trp Gly Gln Gly Thr Gln 
            100                 105                 110         


Val Thr Val Ser Ser 
        115         


<210>  14
<211>  117
<212>  PRT
<213>  Vicugna pacos

<400>  14

Gln Val Gln Leu Gln Glu Ser Gly Gly Gly Leu Val His Ser Gly Gly 
1               5                   10                  15      


Ser Leu Arg Leu Ser Cys Arg Val Ser Glu Ser Leu Phe Ser Leu Tyr 
            20                  25                  30          


Ala Met Gly Trp Tyr Arg Gln Ala Leu Gly Lys Gln Pro Glu Leu Ile 
        35                  40                  45              


Ala Thr Ile Ser Gly Gly Gly Glu Gly Thr Gly Asn Tyr Ala Asp Pro 
    50                  55                  60                  


Val Lys Gly Arg Phe Thr Ile Ser Arg Asn Asn Ala Asn Asn Thr Val 
65                  70                  75                  80  


Phe Leu Gln Met Asn Ser Leu Lys Pro Glu Asp Thr Ala Val Tyr Tyr 
                85                  90                  95      


Cys Asn Val Tyr Gly Thr Asn Leu Ala Pro Trp Gly Gln Gly Thr Gln 
            100                 105                 110         


Val Thr Val Ser Ser 
        115         


<210>  15
<211>  13
<212>  PRT
<213>  Camelus dromedarius

<400>  15

Gly Gly Asp Thr Arg Pro Tyr Ile Thr Tyr Trp Met Gly 
1               5                   10              


<210>  16
<211>  17
<212>  PRT
<213>  Camelus dromedarius

<400>  16

Thr Ile Tyr Thr Gly Gly Ser Gly Thr Tyr Tyr Ser Asp Ser Val Glu 
1               5                   10                  15      


Gly 
    


<210>  17
<211>  18
<212>  PRT
<213>  Camelus dromedarius

<400>  17

Gly Asn Gly Ala Leu Pro Pro Gly Arg Arg Leu Ser Pro Gln Asn Met 
1               5                   10                  15      


Asp Thr 
        


<210>  18
<211>  10
<212>  PRT
<213>  Vicugna pacos

<400>  18

Glu Thr Leu Phe Ser Leu Tyr Ala Met Gly 
1               5                   10  


<210>  19
<211>  10
<212>  PRT
<213>  Vicugna pacos

<400>  19

Glu Ser Leu Phe Ser Leu Tyr Ala Met Gly 
1               5                   10  


<210>  20
<211>  18
<212>  PRT
<213>  Vicugna pacos

<400>  20

Thr Ile Ser Gly Gly Gly Glu Gly Thr Gly Asn Tyr Ala Asp Pro Val 
1               5                   10                  15      


Lys Gly 
        


<210>  21
<211>  7
<212>  PRT
<213>  Vicugna pacos

<400>  21

Tyr Gly Thr Asn Leu Ala Pro 
1               5           


<210>  22
<211>  10
<212>  PRT
<213>  Camelus dromedarius

<400>  22

Gly Leu Pro Tyr Arg Thr Val Phe Met Gly 
1               5                   10  


<210>  23
<211>  10
<212>  PRT
<213>  Camelus dromedarius

<400>  23

Gly Leu Pro Tyr Arg Val Val Phe Met Gly 
1               5                   10  


<210>  24
<211>  17
<212>  PRT
<213>  Camelus dromedarius

<400>  24

Val Ile Asn Ala Asp Gly Val Ser Thr Tyr Tyr Ala Asp Ser Val Lys 
1               5                   10                  15      


Gly 
    


<210>  25
<211>  18
<212>  PRT
<213>  Camelus dromedarius

<400>  25

Asn His Phe Phe Asp Tyr Ser Arg Asp Pro Leu Ala Thr Ala Glu Tyr 
1               5                   10                  15      


Asn Tyr 
        


<210>  26
<211>  10
<212>  PRT
<213>  Camelus dromedarius

<400>  26

Gly Tyr Thr Phe Ser Ser Tyr Cys Met Gly 
1               5                   10  


<210>  27
<211>  16
<212>  PRT
<213>  Camelus dromedarius

<400>  27

Thr Ile Ile Ser Asp Gly Ser Thr Tyr Tyr Ala Asp Ser Val Lys Gly 
1               5                   10                  15      


<210>  28
<211>  15
<212>  PRT
<213>  Camelus dromedarius

<400>  28

Arg Ser Gly Gly Val Cys Ser Gly Arg Ala Ser Arg Tyr Asn Tyr 
1               5                   10                  15  


