                         SEQUENCE LISTING

<110>  The Johns Hopkins University
       Amplimmune, Inc.
       Chen, Lieping
       Yao, Sheng
       Liu, Linda
       Langermann, Solomon
 
<120>  Anti-B7-H5 Antibodies and Their Uses

<130>  AMP 1164

<150>  61/827,216
<151>  2013-05-24

<160>  29    

<170>  PatentIn version 3.5

<210>  1
<211>  414
<212>  PRT
<213>  Homo sapiens

<400>  1

Met Lys Ala Gln Thr Ala Leu Ser Phe Phe Leu Ile Leu Ile Thr Ser 
1               5                   10                  15      


Leu Ser Gly Ser Gln Gly Ile Phe Pro Leu Ala Phe Phe Ile Tyr Val 
            20                  25                  30          


Pro Met Asn Glu Gln Ile Val Ile Gly Arg Leu Asp Glu Asp Ile Ile 
        35                  40                  45              


Leu Pro Ser Ser Phe Glu Arg Gly Ser Glu Val Val Ile His Trp Lys 
    50                  55                  60                  


Tyr Gln Asp Ser Tyr Lys Val His Ser Tyr Tyr Lys Gly Ser Asp His 
65                  70                  75                  80  


Leu Glu Ser Gln Asp Pro Arg Tyr Ala Asn Arg Thr Ser Leu Phe Tyr 
                85                  90                  95      


Asn Glu Ile Gln Asn Gly Asn Ala Ser Leu Phe Phe Arg Arg Val Ser 
            100                 105                 110         


Leu Leu Asp Glu Gly Ile Tyr Thr Cys Tyr Val Gly Thr Ala Ile Gln 
        115                 120                 125             


Val Ile Thr Asn Lys Val Val Leu Lys Val Gly Val Phe Leu Thr Pro 
    130                 135                 140                 


Val Met Lys Tyr Glu Lys Arg Asn Thr Asn Ser Phe Leu Ile Cys Ser 
145                 150                 155                 160 


Val Leu Ser Val Tyr Pro Arg Pro Ile Ile Thr Trp Lys Met Asp Asn 
                165                 170                 175     


Thr Pro Ile Ser Glu Asn Asn Met Glu Glu Thr Gly Ser Leu Asp Ser 
            180                 185                 190         


Phe Ser Ile Asn Ser Pro Leu Asn Ile Thr Gly Ser Asn Ser Ser Tyr 
        195                 200                 205             


Glu Cys Thr Ile Glu Asn Ser Leu Leu Lys Gln Thr Trp Thr Gly Arg 
    210                 215                 220                 


Trp Thr Met Lys Asp Gly Leu His Lys Met Gln Ser Glu His Val Ser 
225                 230                 235                 240 


Leu Ser Cys Gln Pro Val Asn Asp Tyr Phe Ser Pro Asn Gln Asp Phe 
                245                 250                 255     


Lys Val Thr Trp Ser Arg Met Lys Ser Gly Thr Phe Ser Val Leu Ala 
            260                 265                 270         


Tyr Tyr Leu Ser Ser Ser Gln Asn Thr Ile Ile Asn Glu Ser Arg Phe 
        275                 280                 285             


Ser Trp Asn Lys Glu Leu Ile Asn Gln Ser Asp Phe Ser Met Asn Leu 
    290                 295                 300                 


Met Asp Leu Asn Leu Ser Asp Ser Gly Glu Tyr Leu Cys Asn Ile Ser 
305                 310                 315                 320 


Ser Asp Glu Tyr Thr Leu Leu Thr Ile His Thr Val His Val Glu Pro 
                325                 330                 335     


Ser Gln Glu Thr Ala Ser His Asn Lys Gly Leu Trp Ile Leu Val Pro 
            340                 345                 350         


Ser Ala Ile Leu Ala Ala Phe Leu Leu Ile Trp Ser Val Lys Cys Cys 
        355                 360                 365             


Arg Ala Gln Leu Glu Ala Arg Arg Ser Arg His Pro Ala Asp Gly Ala 
    370                 375                 380                 


Gln Gln Glu Arg Cys Cys Val Pro Pro Gly Glu Arg Cys Pro Ser Ala 
385                 390                 395                 400 


Pro Asp Asn Gly Glu Glu Asn Val Pro Leu Ser Gly Lys Val 
                405                 410                 


<210>  2
<211>  1242
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic Polynucleotide - human B7-H5 cDNA

<400>  2
atgaaggcac agacagcact gtctttcttc ctcattctca taacatctct gagtggatct       60

caaggcatat tccctttggc tttcttcatt tatgttccta tgaatgaaca aatcgtcatt      120

ggaagacttg atgaagatat aattctccct tcttcatttg agaggggatc cgaagtcgta      180

atacactgga agtatcaaga tagctataag gttcatagtt actacaaagg cagtgaccat      240

ttggaaagcc aagatcccag atatgcaaac aggacatccc ttttctataa tgagattcaa      300

aatgggaatg cgtcactatt tttcagaaga gtaagccttc tggacgaagg aatttacacc      360

tgctatgtag gaacagcaat tcaagtgatt acaaacaaag tggtgctaaa ggtgggagtt      420

tttctcacac ccgtgatgaa gtatgaaaag aggaacacaa acagcttctt aatatgcagc      480

gtgttaagtg tttatcctcg tccaattatc acgtggaaaa tggacaacac acctatctct      540

gaaaacaaca tggaagaaac agggtctttg gattcttttt ctattaacag cccactgaat      600

attacaggat caaattcatc ttatgaatgt acaattgaaa attcactgct gaagcaaaca      660

tggacagggc gctggacgat gaaagatggc cttcataaaa tgcaaagtga acacgtttca      720

ctctcatgtc aacctgtaaa tgattatttt tcaccaaacc aagacttcaa agttacttgg      780

tccagaatga aaagtgggac tttctctgtc ctggcttact atctgagctc ctcacaaaat      840

acaattatca atgaatcccg attctcatgg aacaaagagc tgataaacca gagtgacttc      900

tctatgaatt tgatggatct taatctttca gacagtgggg aatatttatg caatatttct      960

tcggatgaat atactttact taccatccac acagtgcatg tagaaccgag ccaagaaaca     1020

gcttcccata acaaaggctt atggattttg gtgccctctg cgattttggc agcttttctg     1080

ctgatttgga gcgtaaaatg ttgcagagcc cagctagaag ccaggaggag cagacaccct     1140

gctgatggag cccaacaaga aagatgttgt gtccctcctg gtgagcgctg tcccagtgca     1200

cccgataatg gcgaagaaaa tgtgcctctt tcaggaaaag ta                        1242


<210>  3
<211>  356
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic Polypeptide - B7-H5 fusion protein

<400>  3

Ile Phe Pro Leu Ala Phe Phe Ile Tyr Val Pro Met Asn Glu Gln Ile 
1               5                   10                  15      


Val Ile Gly Arg Leu Asp Glu Asp Ile Ile Leu Pro Ser Ser Phe Glu 
            20                  25                  30          


Arg Gly Ser Glu Val Val Ile His Trp Lys Tyr Gln Asp Ser Tyr Lys 
        35                  40                  45              


Val His Ser Tyr Tyr Lys Gly Ser Asp His Leu Glu Ser Gln Asp Pro 
    50                  55                  60                  


Arg Tyr Ala Asn Arg Thr Ser Leu Phe Tyr Asn Glu Ile Gln Asn Gly 
65                  70                  75                  80  


Asn Ala Ser Leu Phe Phe Arg Arg Val Ser Leu Leu Asp Glu Gly Ile 
                85                  90                  95      


Tyr Thr Cys Tyr Val Gly Thr Ala Ile Gln Val Ile Thr Asn Lys Val 
            100                 105                 110         


Val Leu Lys Val Gly Val Phe Leu Thr Pro Val Met Lys Tyr Glu Lys 
        115                 120                 125             


Glu Ser Lys Tyr Gly Pro Pro Cys Pro Pro Cys Pro Ala Pro Glu Phe 
    130                 135                 140                 


Leu Gly Gly Pro Ser Val Phe Leu Phe Pro Pro Lys Pro Lys Asp Thr 
145                 150                 155                 160 


Leu Met Ile Ser Arg Thr Pro Glu Val Thr Cys Val Val Val Asp Val 
                165                 170                 175     


Ser Gln Glu Asp Pro Glu Val Gln Phe Asn Trp Tyr Val Asp Gly Val 
            180                 185                 190         


Glu Val His Asn Ala Lys Thr Lys Pro Arg Glu Glu Gln Phe Asn Ser 
        195                 200                 205             


Thr Tyr Arg Val Val Ser Val Leu Thr Val Leu His Gln Asp Trp Leu 
    210                 215                 220                 


Asn Gly Lys Glu Tyr Lys Cys Lys Val Ser Asn Lys Gly Leu Pro Ser 
225                 230                 235                 240 


Ser Ile Glu Lys Thr Ile Ser Lys Ala Lys Gly Gln Pro Arg Glu Pro 
                245                 250                 255     


Gln Val Tyr Thr Leu Pro Pro Ser Gln Glu Glu Met Thr Lys Asn Gln 
            260                 265                 270         


Val Ser Leu Thr Cys Leu Val Lys Gly Phe Tyr Pro Ser Asp Ile Ala 
        275                 280                 285             


Val Glu Trp Glu Ser Asn Gly Gln Pro Glu Asn Asn Tyr Lys Thr Thr 
    290                 295                 300                 


Pro Pro Val Leu Asp Ser Asp Gly Ser Phe Phe Leu Tyr Ser Arg Leu 
305                 310                 315                 320 


Thr Val Asp Lys Ser Arg Trp Gln Glu Gly Asn Val Phe Ser Cys Ser 
                325                 330                 335     


Val Met His Glu Ala Leu His Asn His Tyr Thr Gln Lys Ser Leu Ser 
            340                 345                 350         


Leu Ser Pro Gly 
        355     


<210>  4
<211>  22
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic Polypeptide - signal sequence

<400>  4

Met Lys Ala Gln Thr Ala Leu Ser Phe Phe Leu Ile Leu Ile Thr Ser 
1               5                   10                  15      


Leu Ser Gly Ser Gln Gly 
            20          


<210>  5
<211>  66
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic Polynucleotide - nucleic acid encoding a signal 
       sequence

<400>  5
atgaaggccc agaccgccct gtccttcttc ctgatcctga tcacctccct gtccggcagc       60

caggga                                                                  66


<210>  6
<211>  1068
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic Polynucleotide - Sequence encoding a fusion protein

<400>  6
atcttccctc tggccttctt catctacgtg cccatgaacg agcagatcgt gatcggccgg       60

ctggacgagg atattatcct gccctccagc ttcgagcggg gctccgaggt cgtgatccac      120

tggaagtacc aggactccta caaggtgcac tcctactaca agggctccga ccacctggaa      180

tcccaggacc ccagatacgc caaccggacc agcctgttct acaacgagat ccagaacggc      240

aacgcctccc tgttcttccg gcgagtgtcc ctgctggatg agggcatcta cacctgttac      300

gtgggcaccg ccatccaagt gatcaccaac aaggtggtgc tgaaagtggg cgtgttcctg      360

acccccgtga tgaagtacga gaaagagtct aagtacggcc ctccctgccc cccttgtcct      420

gcccctgaat ttctgggcgg accctctgtg ttcctgttcc ccccaaagcc caaggacacc      480

ctgatgatct cccggacccc cgaagtgacc tgcgtggtgg tggatgtgtc ccaggaagat      540

cccgaggtgc agttcaattg gtacgtggac ggcgtggaag tgcacaacgc caagaccaag      600

cccagagagg aacagttcaa ctccacctac cgggtggtgt ccgtgctgac cgtgctgcac      660

caggattggc tgaacggcaa agagtacaag tgcaaggtgt ccaacaaggg cctgcccagc      720

tccatcgaaa agaccatctc caaggccaag ggccagcccc gggaacccca ggtgtacaca      780

ctgcctccaa gccaggaaga gatgaccaag aaccaggtgt ccctgacctg tctcgtgaag      840

ggcttctacc cctccgatat cgccgtggaa tgggagtcca acggccagcc tgagaacaac      900

tacaagacca ccccccctgt gctggactcc gacggctctt tcttcctgta ctcccgcctg      960

accgtggaca agtccagatg gcaggaaggc aacgtgttct cctgctccgt gatgcacgag     1020

gccctgcaca accactacac ccagaagtcc ctgtccctga gccccggc                  1068


<210>  7
<211>  282
<212>  PRT
<213>  Homo sapiens

<400>  7

Met Gly Ser Pro Gly Met Val Leu Gly Leu Leu Val Gln Ile Trp Ala 
1               5                   10                  15      


Leu Gln Glu Ala Ser Ser Leu Ser Val Gln Gln Gly Pro Asn Leu Leu 
            20                  25                  30          


Gln Val Arg Gln Gly Ser Gln Ala Thr Leu Val Cys Gln Val Asp Gln 
        35                  40                  45              


Ala Thr Ala Trp Glu Arg Leu Arg Val Lys Trp Thr Lys Asp Gly Ala 
    50                  55                  60                  


Ile Leu Cys Gln Pro Tyr Ile Thr Asn Gly Ser Leu Ser Leu Gly Val 
65                  70                  75                  80  


Cys Gly Pro Gln Gly Arg Leu Ser Trp Gln Ala Pro Ser His Leu Thr 
                85                  90                  95      


Leu Gln Leu Asp Pro Val Ser Leu Asn His Ser Gly Ala Tyr Val Cys 
            100                 105                 110         


Trp Ala Ala Val Glu Ile Pro Glu Leu Glu Glu Ala Glu Gly Asn Ile 
        115                 120                 125             


Thr Arg Leu Phe Val Asp Pro Asp Asp Pro Thr Gln Asn Arg Asn Arg 
    130                 135                 140                 


Ile Ala Ser Phe Pro Gly Phe Leu Phe Val Leu Leu Gly Val Gly Ser 
145                 150                 155                 160 


Met Gly Val Ala Ala Ile Val Trp Gly Ala Trp Phe Trp Gly Arg Arg 
                165                 170                 175     


Ser Cys Gln Gln Arg Asp Ser Gly Asn Ser Pro Gly Asn Ala Phe Tyr 
            180                 185                 190         


Ser Asn Val Leu Tyr Arg Pro Arg Gly Ala Pro Lys Lys Ser Glu Asp 
        195                 200                 205             


Cys Ser Gly Glu Gly Lys Asp Gln Arg Gly Gln Ser Ile Tyr Ser Thr 
    210                 215                 220                 


Ser Phe Pro Gln Pro Ala Pro Arg Gln Pro His Leu Ala Ser Arg Pro 
225                 230                 235                 240 


Cys Pro Ser Pro Arg Pro Cys Pro Ser Pro Arg Pro Gly His Pro Val 
                245                 250                 255     


Ser Met Val Arg Val Ser Pro Arg Pro Ser Pro Thr Gln Gln Pro Arg 
            260                 265                 270         


Pro Lys Gly Phe Pro Lys Val Gly Glu Glu 
        275                 280         


<210>  8
<211>  846
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic Polynucleotide - cDNA encoding human CD28H

<400>  8
atggggtccc cgggcatggt gctgggcctc ctggtgcaga tctgggccct gcaagaagcc       60

tcaagcctga gcgtgcagca ggggcccaac ttgctgcagg tgaggcaggg cagtcaggcg      120

accctggtct gccaggtgga ccaggccaca gcctgggaac ggctccgtgt taagtggaca      180

aaggatgggg ccatcctgtg tcaaccgtac atcaccaacg gcagcctcag cctgggggtc      240

tgcgggcccc agggacggct ctcctggcag gcacccagcc atctcaccct gcagctggac      300

cctgtgagcc tcaaccacag cggggcgtac gtgtgctggg cggccgtaga gattcctgag      360

ttggaggagg ctgagggcaa cataacaagg ctctttgtgg acccagatga ccccacacag      420

aacagaaacc ggatcgcaag cttcccagga ttcctcttcg tgctgctggg ggtgggaagc      480

atgggtgtgg ctgcgatcgt gtggggtgcc tggttctggg gccgccgcag ctgccagcaa      540

agggactcag gtaacagccc aggaaatgca ttctacagca acgtcctata ccggccccgg      600

ggggccccaa agaagagtga ggactgctct ggagagggga aggaccagag gggccagagc      660

atttattcaa cctccttccc gcaaccggcc ccccgccagc cgcacctggc gtcaagaccc      720

tgccccagcc cgagaccctg ccccagcccc aggcccggcc accccgtctc tatggtcagg      780

gtctctccta gaccaagccc cacccagcag ccgaggccaa aagggttccc caaagtggga      840

gaggag                                                                 846


<210>  9
<211>  117
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic Polynucleotide - Heavy Chain Variable Region Anti-Human
       B7-H5 Clone 2D3

<400>  9

Gln Val Gln Leu Gln Gln Ser Gly Ala Glu Leu Val Lys Pro Gly Ala 
1               5                   10                  15      


Ser Val Lys Leu Ser Cys Lys Ala Ser Gly Tyr Thr Phe Thr Ser His 
            20                  25                  30          


Asp Ile Asn Trp Val Arg Gln Arg Pro Glu Leu Gly Leu Glu Trp Ile 
        35                  40                  45              


Gly Trp Ile Phe Pro Gly Asp Gly Ser Thr Lys Phe Asn Glu Lys Phe 
    50                  55                  60                  


Lys Gly Lys Ala Thr Leu Thr Thr Asp Lys Ser Ser Ser Thr Ala Tyr 
65                  70                  75                  80  


Ile Gln Leu Ser Arg Leu Thr Ser Glu Asp Ser Ala Val Tyr Phe Cys 
                85                  90                  95      


Ala Arg Asn Ser Phe Tyr Ser Met Asp Tyr Trp Gly Gln Gly Thr Ser 
            100                 105                 110         


Val Thr Val Ser Ser 
        115         


<210>  10
<211>  351
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic Polynucleotide - Polynucleotide Encoding Heavy Chain 
       Variable Region Anti-Human B7-H5 Clone 2D3

<400>  10
caggttcaac tgcaacagtc tggagctgaa ctggtaaagc ctggggcttc agtgaagttg       60

tcctgcaagg cttctggcta caccttcaca agccatgata taaactgggt gaggcagagg      120

cctgaactgg gacttgagtg gattggatgg atttttcctg gggatggtag tactaagttc      180

aatgagaagt tcaagggcaa ggccacactg actacagaca aatcctccag cacagcctac      240

atacagctca gcaggctgac gtctgaggac tctgctgtct atttctgtgc aagaaactcc      300

ttctactcta tggactattg gggtcaagga acctcagtca ccgtctcctc a               351


<210>  11
<211>  112
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic Polypeptide - Light Chain Variable Region Anti-Human 
       B7-H5 Clone 2D3

<400>  11

Asp Ile Val Met Ser Gln Ser Pro Ser Ser Leu Ala Val Ser Ala Gly 
1               5                   10                  15      


Glu Lys Val Thr Met Ser Cys Lys Ser Ser Gln Ser Leu Leu Asn Ser 
            20                  25                  30          


Arg Thr Arg Lys Asn Gln Leu Ala Trp Tyr Gln Gln Lys Pro Gly Gln 
        35                  40                  45              


Ser Pro Lys Leu Leu Ile Tyr Trp Ala Phe Ile Arg Glu Ser Gly Val 
    50                  55                  60                  


Pro Asp Arg Phe Thr Gly Ser Gly Ser Gly Thr Asp Phe Thr Leu Thr 
65                  70                  75                  80  


Ile Ser Ser Val Gln Ala Glu Asp Leu Ala Val Tyr Tyr Cys Lys Gln 
                85                  90                  95      


Ser Tyr Asn Leu Arg Thr Phe Gly Gly Gly Thr Lys Leu Glu Ile Lys 
            100                 105                 110         


<210>  12
<211>  337
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic Polynucleotide - Polynucleotide Encoding Light Chain 
       Variable Region Anti-Human B7-H5 Clone 2D3

<400>  12
gacattgtga tgtcacagtc tccatcctcc ctggctgtgt cagcaggaga gaaggtcact       60

atgagctgca aatccagtca gagtctgctc aacagtagaa cccgaaagaa ccagttggct      120

tggtaccagc agaaaccagg acagtctcct aaattactga tctactgggc attcattagg      180

gaatctgggg tccctgatcg cttcacaggc agtggatctg ggacagattt cactctcacc      240

atcagcagtg tgcaggctga agacctggca gtttattact gcaagcaatc ttataatctt      300

cggacgttcg gtggaggcac caagctggaa atcaaac                               337


<210>  13
<211>  117
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic Polypeptide - Heavy Chain Variable Region Anti-Human 
       B7-H5 Clone 18C3

<400>  13

Gln Val Gln Leu Gln Gln Ser Gly Ala Glu Leu Val Lys Pro Gly Ala 
1               5                   10                  15      


Ser Val Lys Leu Ser Cys Lys Ala Ser Gly Tyr Thr Phe Thr Ser His 
            20                  25                  30          


Asp Ile Asn Trp Val Arg Gln Arg Pro Glu Gln Gly Leu Glu Trp Ile 
        35                  40                  45              


Gly Trp Ile Phe Pro Gly Asp Gly Ser Thr Lys Phe Asn Glu Lys Phe 
    50                  55                  60                  


Lys Gly Lys Ala Thr Leu Thr Thr Asp Lys Ser Ser Ser Thr Ala Tyr 
65                  70                  75                  80  


Ile Gln Leu Ser Arg Leu Thr Ser Glu Asp Ser Ala Val Tyr Phe Cys 
                85                  90                  95      


Ala Arg Asn Ser Phe Tyr Ser Met Asp Tyr Trp Gly Gln Gly Thr Ser 
            100                 105                 110         


Val Thr Val Ser Ser 
        115         


<210>  14
<211>  351
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic Polynucleotide - Polynucleotide Encoding Heavy Chain 
       Variable Region Anti-Human B7-H5 Clone 18C3

<400>  14
caggttcaac tgcagcagtc tggagctgaa ctggtaaagc ctggggcttc agtgaagttg       60

tcctgcaagg cttctggcta caccttcaca agccatgata taaactgggt gaggcagagg      120

cctgaacagg gacttgagtg gattggatgg atttttcctg gggatggtag tactaagttc      180

aatgagaagt tcaagggcaa ggccacactg actacagaca aatcctccag cacagcctac      240

atacagctca gcaggctgac atctgaggac tctgctgtct atttctgtgc aagaaactcc      300

ttctattcta tggactactg gggtcaagga acctcagtca ccgtctcctc a               351


<210>  15
<211>  112
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic Polypeptide - Light Chain Variable Region Anti-Human 
       B7-H5 Clone 18C3

<400>  15

Asp Ile Val Met Ser Gln Ser Pro Ser Ser Leu Ala Val Ser Ala Gly 
1               5                   10                  15      


Glu Lys Val Thr Met Ser Cys Lys Ser Ser Gln Ser Leu Leu Asn Ser 
            20                  25                  30          


Arg Thr Arg Lys Asn Gln Leu Ala Trp Tyr Gln Gln Lys Pro Gly Gln 
        35                  40                  45              


Ser Pro Lys Leu Leu Ile Tyr Trp Ala Ser Thr Arg Glu Ser Gly Val 
    50                  55                  60                  


Pro Asp Arg Phe Thr Gly Ser Gly Ser Gly Thr Asp Phe Thr Leu Thr 
65                  70                  75                  80  


Ile Ser Ser Val Gln Ala Glu Asp Leu Ala Val Tyr Tyr Cys Lys Gln 
                85                  90                  95      


Ser Tyr Asn Leu Arg Thr Phe Gly Gly Gly Thr Lys Leu Glu Ile Lys 
            100                 105                 110         


<210>  16
<211>  4
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic Polypeptide - linker

<400>  16

Gly Ser Gly Ser 
1               


<210>  17
<211>  4
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic Polypeptide - Linker

<400>  17

Gly Gly Gly Ser 
1               


<210>  18
<211>  15
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic Polypeptide - linker

<400>  18

Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser 
1               5                   10                  15  


<210>  19
<211>  20
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic Polypeptide - Linker

<400>  19

Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Gly 
1               5                   10                  15      


Gly Gly Gly Ser 
            20  


<210>  20
<211>  347
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic Polypeptide - CD28H-hIgG4 fusion protein

<400>  20

Leu Ser Val Gln Gln Gly Pro Asn Leu Leu Gln Val Arg Gln Gly Ser 
1               5                   10                  15      


Gln Ala Thr Leu Val Cys Gln Val Asp Gln Ala Thr Ala Trp Glu Arg 
            20                  25                  30          


Leu Arg Val Lys Trp Thr Lys Asp Gly Ala Ile Leu Cys Gln Pro Tyr 
        35                  40                  45              


Ile Thr Asn Gly Ser Leu Ser Leu Gly Val Cys Gly Pro Gln Gly Arg 
    50                  55                  60                  


Leu Ser Trp Gln Ala Pro Ser His Leu Thr Leu Gln Leu Asp Pro Val 
65                  70                  75                  80  


Ser Leu Asn His Ser Gly Ala Tyr Val Cys Trp Ala Ala Val Glu Ile 
                85                  90                  95      


Pro Glu Leu Glu Glu Ala Glu Gly Asn Ile Thr Arg Leu Phe Val Asp 
            100                 105                 110         


Pro Asp Asp Pro Thr Gln Glu Ser Lys Tyr Gly Pro Pro Cys Pro Pro 
        115                 120                 125             


Cys Pro Ala Pro Glu Phe Leu Gly Gly Pro Ser Val Phe Leu Phe Pro 
    130                 135                 140                 


Pro Lys Pro Lys Asp Thr Leu Met Ile Ser Arg Thr Pro Glu Val Thr 
145                 150                 155                 160 


Cys Val Val Val Asp Val Ser Gln Glu Asp Pro Glu Val Gln Phe Asn 
                165                 170                 175     


Trp Tyr Val Asp Gly Val Glu Val His Asn Ala Lys Thr Lys Pro Arg 
            180                 185                 190         


Glu Glu Gln Phe Asn Ser Thr Tyr Arg Val Val Ser Val Leu Thr Val 
        195                 200                 205             


Leu His Gln Asp Trp Leu Asn Gly Lys Glu Tyr Lys Cys Lys Val Ser 
    210                 215                 220                 


Asn Lys Gly Leu Pro Ser Ser Ile Glu Lys Thr Ile Ser Lys Ala Lys 
225                 230                 235                 240 


Gly Gln Pro Arg Glu Pro Gln Val Tyr Thr Leu Pro Pro Ser Gln Glu 
                245                 250                 255     


Glu Met Thr Lys Asn Gln Val Ser Leu Thr Cys Leu Val Lys Gly Phe 
            260                 265                 270         


Tyr Pro Ser Asp Ile Ala Val Glu Trp Glu Ser Asn Gly Gln Pro Glu 
        275                 280                 285             


Asn Asn Tyr Lys Thr Thr Pro Pro Val Leu Asp Ser Asp Gly Ser Phe 
    290                 295                 300                 


Phe Leu Tyr Ser Arg Leu Thr Val Asp Lys Ser Arg Trp Gln Glu Gly 
305                 310                 315                 320 


Asn Val Phe Ser Cys Ser Val Met His Glu Ala Leu His Asn His Tyr 
                325                 330                 335     


Thr Gln Lys Ser Leu Ser Leu Ser Pro Gly Lys 
            340                 345         


<210>  21
<211>  20
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic Polypeptide - signal sequence

<400>  21

Met Ser Val Pro Thr Gln Val Leu Gly Leu Leu Leu Leu Trp Leu Thr 
1               5                   10                  15      


Asp Ala Arg Cys 
            20  


<210>  22
<211>  22
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic Polypeptide - signal sequence

<400>  22

Met Gly Ser Pro Gly Met Val Leu Gly Leu Leu Val Gln Ile Trp Ala 
1               5                   10                  15      


Leu Gln Glu Ala Ser Ser 
            20          


<210>  23
<211>  1104
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic Polynucleotide - Polynucleotide encoding a CD28H-Ig

<400>  23
atgtccgtgc ccacccaggt gctgggattg ctgctgctgt ggctgaccga cgccagatgc       60

ctgtctgtgc agcagggccc taacctgctg caagtgcggc agggctctca ggctacactc      120

gtgtgtcagg tggaccaggc caccgcctgg gagagactga gagtgaagtg gaccaaggac      180

ggcgccatcc tgtgccagcc ctacatcacc aacggctccc tgtccctggg cgtgtgtgga      240

cctcagggca gactgtcttg gcaggcccct tctcacctga ccctgcagct ggaccctgtg      300

tccctgaatc actccggcgc ctacgtgtgt tgggccgctg tggaaatccc cgagctggaa      360

gaggccgagg gcaacatcac ccggctgttc gtggaccctg acgaccctac ccaggaatct      420

aagtacggcc ctccctgccc tccttgccca gcccctgaat ttctgggcgg accctccgtg      480

ttcctgttcc ccccaaagcc caaggacacc ctgatgatct cccggacccc cgaagtgacc      540

tgcgtggtgg tggatgtgtc ccaggaagat cccgaggtgc agttcaattg gtacgtggac      600

ggcgtggaag tgcacaacgc caagaccaag cccagagagg aacagttcaa ctccacctac      660

cgggtggtgt ccgtgctgac cgtgctgcac caggattggc tgaacggcaa agagtacaag      720

tgcaaggtgt ccaacaaggg cctgcccagc tccatcgaaa agaccatctc caaggccaag      780

ggccagcccc gggaacccca ggtgtacaca ctgcctccaa gccaggaaga gatgaccaag      840

aaccaggtgt cactgacctg tctcgtgaag ggcttctacc cctccgatat cgccgtggaa      900

tgggagtcca acggccagcc tgagaacaac tacaagacca ccccccctgt gctggactcc      960

gacggctcct tcttcctgta ctcccgcctg accgtggaca agtccagatg gcaggaaggc     1020

aacgtgttct cctgctccgt gatgcacgag gccctgcaca accactacac ccagaagtcc     1080

ctgagcctgt cccccggcaa gtga                                            1104


<210>  24
<211>  546
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic Polypeptide - B7-H5ECD-hIgG4P fusion protein

<400>  24

Ile Phe Pro Leu Ala Phe Phe Ile Tyr Val Pro Met Asn Glu Gln Ile 
1               5                   10                  15      


Val Ile Gly Arg Leu Asp Glu Asp Ile Ile Leu Pro Ser Ser Phe Glu 
            20                  25                  30          


Arg Gly Ser Glu Val Val Ile His Trp Lys Tyr Gln Asp Ser Tyr Lys 
        35                  40                  45              


Val His Ser Tyr Tyr Lys Gly Ser Asp His Leu Glu Ser Gln Asp Pro 
    50                  55                  60                  


Arg Tyr Ala Asn Arg Thr Ser Leu Phe Tyr Asn Glu Ile Gln Asn Gly 
65                  70                  75                  80  


Asn Ala Ser Leu Phe Phe Arg Arg Val Ser Leu Leu Asp Glu Gly Ile 
                85                  90                  95      


Tyr Thr Cys Tyr Val Gly Thr Ala Ile Gln Val Ile Thr Asn Lys Val 
            100                 105                 110         


Val Leu Lys Val Gly Val Phe Leu Thr Pro Val Met Lys Tyr Glu Lys 
        115                 120                 125             


Arg Asn Thr Asn Ser Phe Leu Ile Cys Ser Val Leu Ser Val Tyr Pro 
    130                 135                 140                 


Arg Pro Ile Ile Thr Trp Lys Met Asp Asn Thr Pro Ile Ser Glu Asn 
145                 150                 155                 160 


Asn Met Glu Glu Thr Gly Ser Leu Asp Ser Phe Ser Ile Asn Ser Pro 
                165                 170                 175     


Leu Asn Ile Thr Gly Ser Asn Ser Ser Tyr Glu Cys Thr Ile Glu Asn 
            180                 185                 190         


Ser Leu Leu Lys Gln Thr Trp Thr Gly Arg Trp Thr Met Lys Asp Gly 
        195                 200                 205             


Leu His Lys Met Gln Ser Glu His Val Ser Leu Ser Cys Gln Pro Val 
    210                 215                 220                 


Asn Asp Tyr Phe Ser Pro Asn Gln Asp Phe Lys Val Thr Trp Ser Arg 
225                 230                 235                 240 


Met Lys Ser Gly Thr Phe Ser Val Leu Ala Tyr Tyr Leu Ser Ser Ser 
                245                 250                 255     


Gln Asn Thr Ile Ile Asn Glu Ser Arg Phe Ser Trp Asn Lys Glu Leu 
            260                 265                 270         


Ile Asn Gln Ser Asp Phe Ser Met Asn Leu Met Asp Leu Asn Leu Ser 
        275                 280                 285             


Asp Ser Gly Glu Tyr Leu Cys Asn Ile Ser Ser Asp Glu Tyr Thr Leu 
    290                 295                 300                 


Leu Thr Ile His Thr Val His Val Glu Pro Ser Gln Glu Thr Glu Ser 
305                 310                 315                 320 


Lys Tyr Gly Pro Pro Cys Pro Pro Cys Pro Ala Pro Glu Phe Leu Gly 
                325                 330                 335     


Gly Pro Ser Val Phe Leu Phe Pro Pro Lys Pro Lys Asp Thr Leu Met 
            340                 345                 350         


Ile Ser Arg Thr Pro Glu Val Thr Cys Val Val Val Asp Val Ser Gln 
        355                 360                 365             


Glu Asp Pro Glu Val Gln Phe Asn Trp Tyr Val Asp Gly Val Glu Val 
    370                 375                 380                 


His Asn Ala Lys Thr Lys Pro Arg Glu Glu Gln Phe Asn Ser Thr Tyr 
385                 390                 395                 400 


Arg Val Val Ser Val Leu Thr Val Leu His Gln Asp Trp Leu Asn Gly 
                405                 410                 415     


Lys Glu Tyr Lys Cys Lys Val Ser Asn Lys Gly Leu Pro Ser Ser Ile 
            420                 425                 430         


Glu Lys Thr Ile Ser Lys Ala Lys Gly Gln Pro Arg Glu Pro Gln Val 
        435                 440                 445             


Tyr Thr Leu Pro Pro Ser Gln Glu Glu Met Thr Lys Asn Gln Val Ser 
    450                 455                 460                 


Leu Thr Cys Leu Val Lys Gly Phe Tyr Pro Ser Asp Ile Ala Val Glu 
465                 470                 475                 480 


Trp Glu Ser Asn Gly Gln Pro Glu Asn Asn Tyr Lys Thr Thr Pro Pro 
                485                 490                 495     


Val Leu Asp Ser Asp Gly Ser Phe Phe Leu Tyr Ser Arg Leu Thr Val 
            500                 505                 510         


Asp Lys Ser Arg Trp Gln Glu Gly Asn Val Phe Ser Cys Ser Val Met 
        515                 520                 525             


His Glu Ala Leu His Asn His Tyr Thr Gln Lys Ser Leu Ser Leu Ser 
    530                 535                 540                 


Pro Gly 
545     


<210>  25
<211>  1707
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic Polynucleotide - Polynucleotide encoding a 
       B7-H5ECD-hIgG4P

<400>  25

Ala Thr Gly Ala Ala Gly Gly Cys Cys Cys Ala Gly Ala Cys Cys Gly 
1               5                   10                  15      


Cys Cys Cys Thr Gly Thr Cys Cys Thr Thr Cys Thr Thr Cys Cys Thr 
            20                  25                  30          


Gly Ala Thr Cys Cys Thr Gly Ala Thr Cys Ala Cys Cys Thr Cys Cys 
        35                  40                  45              


Cys Thr Gly Thr Cys Cys Gly Gly Cys Ala Gly Cys Cys Ala Gly Gly 
    50                  55                  60                  


Gly Ala Ala Thr Cys Thr Thr Cys Cys Cys Thr Cys Thr Gly Gly Cys 
65                  70                  75                  80  


Cys Thr Thr Cys Thr Thr Cys Ala Thr Cys Thr Ala Cys Gly Thr Gly 
                85                  90                  95      


Cys Cys Cys Ala Thr Gly Ala Ala Cys Gly Ala Gly Cys Ala Gly Ala 
            100                 105                 110         


Thr Cys Gly Thr Gly Ala Thr Cys Gly Gly Cys Cys Gly Gly Cys Thr 
        115                 120                 125             


Gly Gly Ala Cys Gly Ala Gly Gly Ala Thr Ala Thr Thr Ala Thr Cys 
    130                 135                 140                 


Cys Thr Gly Cys Cys Cys Thr Cys Cys Ala Gly Cys Thr Thr Cys Gly 
145                 150                 155                 160 


Ala Gly Cys Gly Gly Gly Gly Cys Thr Cys Cys Gly Ala Gly Gly Thr 
                165                 170                 175     


Cys Gly Thr Gly Ala Thr Cys Cys Ala Cys Thr Gly Gly Ala Ala Gly 
            180                 185                 190         


Thr Ala Cys Cys Ala Gly Gly Ala Cys Thr Cys Cys Thr Ala Cys Ala 
        195                 200                 205             


Ala Gly Gly Thr Gly Cys Ala Cys Thr Cys Cys Thr Ala Cys Thr Ala 
    210                 215                 220                 


Cys Ala Ala Gly Gly Gly Cys Thr Cys Cys Gly Ala Cys Cys Ala Cys 
225                 230                 235                 240 


Cys Thr Gly Gly Ala Ala Thr Cys Cys Cys Ala Gly Gly Ala Cys Cys 
                245                 250                 255     


Cys Cys Ala Gly Ala Thr Ala Cys Gly Cys Cys Ala Ala Cys Cys Gly 
            260                 265                 270         


Gly Ala Cys Cys Ala Gly Cys Cys Thr Gly Thr Thr Cys Thr Ala Cys 
        275                 280                 285             


Ala Ala Cys Gly Ala Gly Ala Thr Cys Cys Ala Gly Ala Ala Cys Gly 
    290                 295                 300                 


Gly Cys Ala Ala Cys Gly Cys Cys Thr Cys Cys Cys Thr Gly Thr Thr 
305                 310                 315                 320 


Cys Thr Thr Cys Cys Gly Gly Cys Gly Ala Gly Thr Gly Thr Cys Cys 
                325                 330                 335     


Cys Thr Gly Cys Thr Gly Gly Ala Thr Gly Ala Gly Gly Gly Cys Ala 
            340                 345                 350         


Thr Cys Thr Ala Cys Ala Cys Cys Thr Gly Thr Thr Ala Cys Gly Thr 
        355                 360                 365             


Gly Gly Gly Cys Ala Cys Cys Gly Cys Cys Ala Thr Cys Cys Ala Ala 
    370                 375                 380                 


Gly Thr Gly Ala Thr Cys Ala Cys Cys Ala Ala Cys Ala Ala Gly Gly 
385                 390                 395                 400 


Thr Gly Gly Thr Gly Cys Thr Gly Ala Ala Ala Gly Thr Gly Gly Gly 
                405                 410                 415     


Cys Gly Thr Gly Thr Thr Cys Cys Thr Gly Ala Cys Cys Cys Cys Cys 
            420                 425                 430         


Gly Thr Gly Ala Thr Gly Ala Ala Gly Thr Ala Cys Gly Ala Gly Ala 
        435                 440                 445             


Ala Gly Cys Gly Gly Ala Ala Thr Ala Cys Cys Ala Ala Cys Thr Cys 
    450                 455                 460                 


Thr Thr Thr Cys Cys Thr Gly Ala Thr Cys Thr Gly Cys Thr Cys Cys 
465                 470                 475                 480 


Gly Thr Gly Cys Thr Gly Thr Cys Cys Gly Thr Gly Thr Ala Cys Cys 
                485                 490                 495     


Cys Thr Cys Gly Gly Cys Cys Cys Ala Thr Cys Ala Thr Cys Ala Cys 
            500                 505                 510         


Cys Thr Gly Gly Ala Ala Gly Ala Thr Gly Gly Ala Cys Ala Ala Cys 
        515                 520                 525             


Ala Cys Cys Cys Cys Cys Ala Thr Cys Thr Cys Cys Gly Ala Gly Ala 
    530                 535                 540                 


Ala Cys Ala Ala Cys Ala Thr Gly Gly Ala Ala Gly Ala Gly Ala Cys 
545                 550                 555                 560 


Ala Gly Gly Cys Thr Cys Cys Cys Thr Gly Gly Ala Cys Thr Cys Cys 
                565                 570                 575     


Thr Thr Cys Thr Cys Cys Ala Thr Cys Ala Ala Cys Thr Cys Cys Cys 
            580                 585                 590         


Cys Cys Cys Thr Gly Ala Ala Cys Ala Thr Thr Ala Cys Cys Gly Gly 
        595                 600                 605             


Cys Thr Cys Cys Ala Ala Cys Thr Cys Cys Thr Cys Cys Thr Ala Cys 
    610                 615                 620                 


Gly Ala Gly Thr Gly Cys Ala Cys Cys Ala Thr Cys Gly Ala Gly Ala 
625                 630                 635                 640 


Ala Cys Thr Cys Cys Cys Thr Gly Cys Thr Gly Ala Ala Gly Cys Ala 
                645                 650                 655     


Gly Ala Cys Cys Thr Gly Gly Ala Cys Cys Gly Gly Cys Ala Gly Ala 
            660                 665                 670         


Thr Gly Gly Ala Cys Thr Ala Thr Gly Ala Ala Gly Gly Ala Cys Gly 
        675                 680                 685             


Gly Cys Cys Thr Gly Cys Ala Cys Ala Ala Gly Ala Thr Gly Cys Ala 
    690                 695                 700                 


Gly Thr Cys Cys Gly Ala Gly Cys Ala Cys Gly Thr Gly Thr Cys Cys 
705                 710                 715                 720 


Cys Thr Gly Thr Cys Cys Thr Gly Cys Cys Ala Gly Cys Cys Cys Gly 
                725                 730                 735     


Thr Gly Ala Ala Cys Gly Ala Cys Thr Ala Cys Thr Thr Cys Ala Gly 
            740                 745                 750         


Cys Cys Cys Cys Ala Ala Cys Cys Ala Gly Gly Ala Cys Thr Thr Cys 
        755                 760                 765             


Ala Ala Ala Gly Thr Gly Ala Cys Cys Thr Gly Gly Thr Cys Cys Cys 
    770                 775                 780                 


Gly Gly Ala Thr Gly Ala Ala Gly Thr Cys Cys Gly Gly Cys Ala Cys 
785                 790                 795                 800 


Cys Thr Thr Cys Ala Gly Cys Gly Thr Gly Cys Thr Gly Gly Cys Cys 
                805                 810                 815     


Thr Ala Cys Thr Ala Cys Cys Thr Gly Thr Cys Cys Ala Gly Cys Thr 
            820                 825                 830         


Cys Cys Cys Ala Gly Ala Ala Cys Ala Cys Cys Ala Thr Cys Ala Thr 
        835                 840                 845             


Cys Ala Ala Cys Gly Ala Gly Thr Cys Cys Cys Gly Gly Thr Thr Cys 
    850                 855                 860                 


Thr Cys Cys Thr Gly Gly Ala Ala Cys Ala Ala Ala Gly Ala Gly Cys 
865                 870                 875                 880 


Thr Gly Ala Thr Cys Ala Ala Cys Cys Ala Gly Thr Cys Cys Gly Ala 
                885                 890                 895     


Cys Thr Thr Cys Thr Cys Cys Ala Thr Gly Ala Ala Cys Cys Thr Gly 
            900                 905                 910         


Ala Thr Gly Gly Ala Cys Cys Thr Gly Ala Ala Cys Cys Thr Gly Thr 
        915                 920                 925             


Cys Cys Gly Ala Cys Ala Gly Cys Gly Gly Cys Gly Ala Gly Thr Ala 
    930                 935                 940                 


Cys Cys Thr Gly Thr Gly Cys Ala Ala Cys Ala Thr Cys Thr Cys Cys 
945                 950                 955                 960 


Ala Gly Cys Gly Ala Cys Gly Ala Gly Thr Ala Cys Ala Cys Cys Cys 
                965                 970                 975     


Thr Gly Cys Thr Gly Ala Cys Cys Ala Thr Cys Cys Ala Cys Ala Cys 
            980                 985                 990         


Cys Gly Thr Gly Cys Ala Cys Gly  Thr Gly Gly Ala Ala  Cys Cys Cys 
        995                 1000                 1005             


Thr Cys  Cys Cys Ala Gly Gly  Ala Ala Ala Cys Cys  Gly Ala Gly 
    1010                 1015                 1020             


Thr Cys  Thr Ala Ala Gly Thr  Ala Cys Gly Gly Cys  Cys Cys Thr 
    1025                 1030                 1035             


Cys Cys  Cys Thr Gly Cys Cys  Cys Ala Cys Cys Thr  Thr Gly Thr 
    1040                 1045                 1050             


Cys Cys  Cys Gly Cys Cys Cys  Cys Thr Gly Ala Ala  Thr Thr Thr 
    1055                 1060                 1065             


Cys Thr  Gly Gly Gly Cys Gly  Gly Ala Cys Cys Cys  Thr Cys Thr 
    1070                 1075                 1080             


Gly Thr  Gly Thr Thr Cys Cys  Thr Gly Thr Thr Cys  Cys Cys Cys 
    1085                 1090                 1095             


Cys Cys  Ala Ala Ala Gly Cys  Cys Cys Ala Ala Gly  Gly Ala Cys 
    1100                 1105                 1110             


Ala Cys  Cys Cys Thr Gly Ala  Thr Gly Ala Thr Cys  Thr Cys Cys 
    1115                 1120                 1125             


Cys Gly  Gly Ala Cys Cys Cys  Cys Cys Gly Ala Ala  Gly Thr Gly 
    1130                 1135                 1140             


Ala Cys  Ala Thr Gly Cys Gly  Thr Gly Gly Thr Gly  Gly Thr Gly 
    1145                 1150                 1155             


Gly Ala  Thr Gly Thr Gly Thr  Cys Cys Cys Ala Gly  Gly Ala Ala 
    1160                 1165                 1170             


Gly Ala  Thr Cys Cys Cys Gly  Ala Gly Gly Thr Gly  Cys Ala Gly 
    1175                 1180                 1185             


Thr Thr  Cys Ala Ala Thr Thr  Gly Gly Thr Ala Cys  Gly Thr Gly 
    1190                 1195                 1200             


Gly Ala  Cys Gly Gly Cys Gly  Thr Gly Gly Ala Ala  Gly Thr Gly 
    1205                 1210                 1215             


Cys Ala  Cys Ala Ala Cys Gly  Cys Cys Ala Ala Gly  Ala Cys Cys 
    1220                 1225                 1230             


Ala Ala  Gly Cys Cys Cys Ala  Gly Ala Gly Ala Gly  Gly Ala Ala 
    1235                 1240                 1245             


Cys Ala  Gly Thr Thr Cys Ala  Ala Cys Thr Cys Cys  Ala Cys Cys 
    1250                 1255                 1260             


Thr Ala  Cys Cys Gly Gly Gly  Thr Gly Gly Thr Gly  Thr Cys Thr 
    1265                 1270                 1275             


Gly Thr  Gly Cys Thr Gly Ala  Cys Cys Gly Thr Gly  Cys Thr Gly 
    1280                 1285                 1290             


Cys Ala  Cys Cys Ala Gly Gly  Ala Cys Thr Gly Gly  Cys Thr Gly 
    1295                 1300                 1305             


Ala Ala  Cys Gly Gly Cys Ala  Ala Ala Gly Ala Gly  Thr Ala Cys 
    1310                 1315                 1320             


Ala Ala  Gly Thr Gly Cys Ala  Ala Gly Gly Thr Gly  Thr Cys Cys 
    1325                 1330                 1335             


Ala Ala  Cys Ala Ala Gly Gly  Gly Cys Cys Thr Gly  Cys Cys Cys 
    1340                 1345                 1350             


Ala Gly  Cys Thr Cys Cys Ala  Thr Cys Gly Ala Ala  Ala Ala Gly 
    1355                 1360                 1365             


Ala Cys  Cys Ala Thr Cys Thr  Cys Cys Ala Ala Gly  Gly Cys Cys 
    1370                 1375                 1380             


Ala Ala  Gly Gly Gly Cys Cys  Ala Gly Cys Cys Cys  Cys Gly Gly 
    1385                 1390                 1395             


Gly Ala  Ala Cys Cys Cys Cys  Ala Gly Gly Thr Gly  Thr Ala Cys 
    1400                 1405                 1410             


Ala Cys  Ala Cys Thr Gly Cys  Cys Thr Cys Cys Ala  Ala Gly Cys 
    1415                 1420                 1425             


Cys Ala  Gly Gly Ala Ala Gly  Ala Gly Ala Thr Gly  Ala Cys Cys 
    1430                 1435                 1440             


Ala Ala  Gly Ala Ala Cys Cys  Ala Gly Gly Thr Gly  Thr Cys Cys 
    1445                 1450                 1455             


Cys Thr  Gly Ala Cys Thr Thr  Gly Cys Cys Thr Cys  Gly Thr Gly 
    1460                 1465                 1470             


Ala Ala  Gly Gly Gly Cys Thr  Thr Cys Thr Ala Cys  Cys Cys Cys 
    1475                 1480                 1485             


Thr Cys  Cys Gly Ala Thr Ala  Thr Cys Gly Cys Cys  Gly Thr Gly 
    1490                 1495                 1500             


Gly Ala  Ala Thr Gly Gly Gly  Ala Gly Thr Cys Cys  Ala Ala Cys 
    1505                 1510                 1515             


Gly Gly  Cys Cys Ala Gly Cys  Cys Thr Gly Ala Gly  Ala Ala Cys 
    1520                 1525                 1530             


Ala Ala  Cys Thr Ala Cys Ala  Ala Gly Ala Cys Cys  Ala Cys Cys 
    1535                 1540                 1545             


Cys Cys  Cys Cys Cys Thr Gly  Thr Gly Cys Thr Gly  Gly Ala Cys 
    1550                 1555                 1560             


Thr Cys  Cys Gly Ala Cys Gly  Gly Cys Thr Cys Thr  Thr Thr Cys 
    1565                 1570                 1575             


Thr Thr  Cys Cys Thr Gly Thr  Ala Cys Thr Cys Cys  Cys Gly Cys 
    1580                 1585                 1590             


Cys Thr  Gly Ala Cys Cys Gly  Thr Gly Gly Ala Cys  Ala Ala Gly 
    1595                 1600                 1605             


Thr Cys  Cys Ala Gly Ala Thr  Gly Gly Cys Ala Gly  Gly Ala Ala 
    1610                 1615                 1620             


Gly Gly  Cys Ala Ala Cys Gly  Thr Gly Thr Thr Cys  Thr Cys Cys 
    1625                 1630                 1635             


Thr Gly  Cys Ala Gly Cys Gly  Thr Gly Ala Thr Gly  Cys Ala Cys 
    1640                 1645                 1650             


Gly Ala  Gly Gly Cys Cys Cys  Thr Gly Cys Ala Cys  Ala Ala Cys 
    1655                 1660                 1665             


Cys Ala  Cys Thr Ala Cys Ala  Cys Cys Cys Ala Gly  Ala Ala Gly 
    1670                 1675                 1680             


Thr Cys  Cys Cys Thr Gly Ala  Gly Cys Cys Thr Gly  Thr Cys Cys 
    1685                 1690                 1695             


Cys Cys  Cys Gly Gly Cys Thr  Gly Ala 
    1700                 1705         


<210>  26
<211>  318
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificial Polypeptide - extracellular domain

<400>  26

Ile Phe Pro Leu Ala Phe Phe Ile Tyr Val Pro Met Asn Glu Gln Ile 
1               5                   10                  15      


Val Ile Gly Arg Leu Asp Glu Asp Ile Ile Leu Pro Ser Ser Phe Glu 
            20                  25                  30          


Arg Gly Ser Glu Val Val Ile His Trp Lys Tyr Gln Asp Ser Tyr Lys 
        35                  40                  45              


Val His Ser Tyr Tyr Lys Gly Ser Asp His Leu Glu Ser Gln Asp Pro 
    50                  55                  60                  


Arg Tyr Ala Asn Arg Thr Ser Leu Phe Tyr Asn Glu Ile Gln Asn Gly 
65                  70                  75                  80  


Asn Ala Ser Leu Phe Phe Arg Arg Val Ser Leu Leu Asp Glu Gly Ile 
                85                  90                  95      


Tyr Thr Cys Tyr Val Gly Thr Ala Ile Gln Val Ile Thr Asn Lys Val 
            100                 105                 110         


Val Leu Lys Val Gly Val Phe Leu Thr Pro Val Met Lys Tyr Glu Lys 
        115                 120                 125             


Arg Asn Thr Asn Ser Phe Leu Ile Cys Ser Val Leu Ser Val Tyr Pro 
    130                 135                 140                 


Arg Pro Ile Ile Thr Trp Lys Met Asp Asn Thr Pro Ile Ser Glu Asn 
145                 150                 155                 160 


Asn Met Glu Glu Thr Gly Ser Leu Asp Ser Phe Ser Ile Asn Ser Pro 
                165                 170                 175     


Leu Asn Ile Thr Gly Ser Asn Ser Ser Tyr Glu Cys Thr Ile Glu Asn 
            180                 185                 190         


Ser Leu Leu Lys Gln Thr Trp Thr Gly Arg Trp Thr Met Lys Asp Gly 
        195                 200                 205             


Leu His Lys Met Gln Ser Glu His Val Ser Leu Ser Cys Gln Pro Val 
    210                 215                 220                 


Asn Asp Tyr Phe Ser Pro Asn Gln Asp Phe Lys Val Thr Trp Ser Arg 
225                 230                 235                 240 


Met Lys Ser Gly Thr Phe Ser Val Leu Ala Tyr Tyr Leu Ser Ser Ser 
                245                 250                 255     


Gln Asn Thr Ile Ile Asn Glu Ser Arg Phe Ser Trp Asn Lys Glu Leu 
            260                 265                 270         


Ile Asn Gln Ser Asp Phe Ser Met Asn Leu Met Asp Leu Asn Leu Ser 
        275                 280                 285             


Asp Ser Gly Glu Tyr Leu Cys Asn Ile Ser Ser Asp Glu Tyr Thr Leu 
    290                 295                 300                 


Leu Thr Ile His Thr Val His Val Glu Pro Ser Gln Glu Thr 
305                 310                 315             


<210>  27
<211>  233
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic Polypeptide - murine IgG2a domain

<400>  27

Glu Pro Arg Gly Pro Thr Ile Lys Pro Cys Pro Pro Cys Lys Cys Pro 
1               5                   10                  15      


Ala Pro Asn Leu Leu Gly Gly Pro Ser Val Phe Ile Phe Pro Pro Lys 
            20                  25                  30          


Ile Lys Asp Val Leu Met Ile Ser Leu Ser Pro Ile Val Thr Cys Val 
        35                  40                  45              


Val Val Asp Val Ser Glu Asp Asp Pro Asp Val Gln Ile Ser Trp Phe 
    50                  55                  60                  


Val Asn Asn Val Glu Val His Thr Ala Gln Thr Gln Thr His Arg Glu 
65                  70                  75                  80  


Asp Tyr Asn Ser Thr Leu Arg Val Val Ser Ala Leu Pro Ile Gln His 
                85                  90                  95      


Gln Asp Trp Met Ser Gly Lys Glu Phe Lys Cys Lys Val Asn Asn Lys 
            100                 105                 110         


Asp Leu Pro Ala Pro Ile Glu Arg Thr Ile Ser Lys Pro Lys Gly Ser 
        115                 120                 125             


Val Arg Ala Pro Gln Val Tyr Val Leu Pro Pro Pro Glu Glu Glu Met 
    130                 135                 140                 


Thr Lys Lys Gln Val Thr Leu Thr Cys Met Val Thr Asp Phe Met Pro 
145                 150                 155                 160 


Glu Asp Ile Tyr Val Glu Trp Thr Asn Asn Gly Lys Thr Glu Leu Asn 
                165                 170                 175     


Tyr Lys Asn Thr Glu Pro Val Leu Asp Ser Asp Gly Ser Tyr Phe Met 
            180                 185                 190         


Tyr Ser Lys Leu Arg Val Glu Lys Lys Asn Trp Val Glu Arg Asn Ser 
        195                 200                 205             


Tyr Ser Cys Ser Val Val His Glu Gly Leu His Asn His His Thr Thr 
    210                 215                 220                 


Lys Ser Phe Ser Arg Thr Pro Gly Lys 
225                 230             


<210>  28
<211>  337
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic Polynucleotide - Polynucleotide Encoding Light Chain 
       Variable Region Anti-Human B7-H5 Clone 18C3

<400>  28
gacattgtga tgtcacagtc tccatcctcc ctggctgtgt cagcaggaga gaaggtcact       60

atgagctgca aatccagtca gagtctgctc aacagtagaa cccgaaagaa ccagttggct      120

tggtaccagc agaaaccagg gcagtctcct aaactgctga tctactgggc atccactagg      180

gaatctgggg tccctgatcg cttcacaggc agtggatctg ggacagattt cactctcacc      240

atcagcagtg tgcaggctga agacctggca gtttattact gcaagcaatc ttataatctt      300

cggacgttcg gtggaggcac caagctggaa atcaaac                               337


<210>  29
<211>  22
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic Polypeptide - signal sequence

<400>  29

Met Lys Ala Gln Thr Ala Leu Ser Phe Phe Leu Ile Leu Ile Thr Ser 
1               5                   10                  15      


Leu Ser Gly Ser Gln Gly 
            20          


