                         SEQUENCE LISTING

<110>  Shire Human Genetic Therapies, Inc.
 
<120>  ANTI-CCL2 AND ANTI-LOXL2 COMBINATION THERAPY FOR TREATMENT OF SCLERODERMA

<130>  2006685-0569

<150>  61/826692
<151>  2013-05-23

<160>  2     

<170>  PatentIn version 3.5

<210>  1
<211>  99
<212>  PRT
<213>  Homo sapiens

<400>  1

Met Lys Val Ser Ala Ala Leu Leu Cys Leu Leu Leu Ile Ala Ala Thr 
1               5                   10                  15      


Phe Ile Pro Gln Gly Leu Ala Gln Pro Asp Ala Ile Asn Ala Pro Val 
            20                  25                  30          


Thr Cys Cys Tyr Asn Phe Thr Asn Arg Lys Ile Ser Val Gln Arg Leu 
        35                  40                  45              


Ala Ser Tyr Arg Arg Ile Thr Ser Ser Lys Cys Pro Lys Glu Ala Val 
    50                  55                  60                  


Ile Phe Lys Thr Ile Val Ala Lys Glu Ile Cys Ala Asp Pro Lys Gln 
65                  70                  75                  80  


Lys Trp Val Gln Asp Ser Met Asp His Leu Asp Lys Gln Thr Gln Thr 
                85                  90                  95      


Pro Lys Thr 
            


<210>  2
<211>  638
<212>  PRT
<213>  Homo sapiens

<400>  2

Met Glu Gly Tyr Val Glu Val Lys Glu Gly Lys Thr Trp Lys Gln Ile 
1               5                   10                  15      


Cys Asp Lys His Trp Thr Ala Lys Asn Ser Arg Val Val Cys Gly Met 
            20                  25                  30          


Phe Gly Phe Pro Gly Glu Arg Thr Tyr Asn Thr Lys Val Tyr Lys Met 
        35                  40                  45              


Phe Ala Ser Arg Arg Lys Gln Arg Tyr Trp Pro Phe Ser Met Asp Cys 
    50                  55                  60                  


Thr Gly Thr Glu Ala His Ile Ser Ser Cys Lys Leu Gly Pro Gln Val 
65                  70                  75                  80  


Ser Leu Asp Pro Met Lys Asn Val Thr Cys Glu Asn Gly Gln Pro Ala 
                85                  90                  95      


Val Val Ser Cys Val Pro Gly Gln Val Phe Ser Pro Asp Gly Pro Ser 
            100                 105                 110         


Arg Phe Arg Lys Ala Tyr Lys Pro Glu Gln Pro Leu Val Arg Leu Arg 
        115                 120                 125             


Gly Gly Ala Tyr Ile Gly Glu Gly Arg Val Glu Val Leu Lys Asn Gly 
    130                 135                 140                 


Glu Trp Gly Thr Val Cys Asp Asp Lys Trp Asp Leu Val Ser Ala Ser 
145                 150                 155                 160 


Val Val Cys Arg Glu Leu Gly Phe Gly Ser Ala Lys Glu Ala Val Thr 
                165                 170                 175     


Gly Ser Arg Leu Gly Gln Gly Ile Gly Pro Ile His Leu Asn Glu Ile 
            180                 185                 190         


Gln Cys Thr Gly Asn Glu Lys Ser Ile Ile Asp Cys Lys Phe Asn Ala 
        195                 200                 205             


Glu Ser Gln Gly Cys Asn His Glu Glu Asp Ala Gly Val Arg Cys Asn 
    210                 215                 220                 


Thr Pro Ala Met Gly Leu Gln Lys Lys Leu Arg Leu Asn Gly Gly Arg 
225                 230                 235                 240 


Asn Pro Tyr Glu Gly Arg Val Glu Val Leu Val Glu Arg Asn Gly Ser 
                245                 250                 255     


Leu Val Trp Gly Met Val Cys Gly Gln Asn Trp Gly Ile Val Glu Ala 
            260                 265                 270         


Met Val Val Cys Arg Gln Leu Gly Leu Gly Phe Ala Ser Asn Ala Phe 
        275                 280                 285             


Gln Glu Thr Trp Tyr Trp His Gly Asp Val Asn Ser Asn Lys Val Val 
    290                 295                 300                 


Met Ser Gly Val Lys Cys Ser Gly Thr Glu Leu Ser Leu Ala His Cys 
305                 310                 315                 320 


Arg His Asp Gly Glu Asp Val Ala Cys Pro Gln Gly Gly Val Gln Tyr 
                325                 330                 335     


Gly Ala Gly Val Ala Cys Ser Glu Thr Ala Pro Asp Leu Val Leu Asn 
            340                 345                 350         


Ala Glu Met Val Gln Gln Thr Thr Tyr Leu Glu Asp Arg Pro Met Phe 
        355                 360                 365             


Met Leu Gln Cys Ala Met Glu Glu Asn Cys Leu Ser Ala Ser Ala Ala 
    370                 375                 380                 


Gln Thr Asp Pro Thr Thr Gly Tyr Arg Arg Leu Leu Arg Phe Ser Ser 
385                 390                 395                 400 


Gln Ile His Asn Asn Gly Gln Ser Asp Phe Arg Pro Lys Asn Gly Arg 
                405                 410                 415     


His Ala Trp Ile Trp His Asp Cys His Arg His Tyr His Ser Met Glu 
            420                 425                 430         


Val Phe Thr His Tyr Asp Leu Leu Asn Leu Asn Gly Thr Lys Val Ala 
        435                 440                 445             


Glu Gly Gln Lys Ala Ser Phe Cys Leu Glu Asp Thr Glu Cys Glu Gly 
    450                 455                 460                 


Asp Ile Gln Lys Asn Tyr Glu Cys Ala Asn Phe Gly Asp Gln Gly Ile 
465                 470                 475                 480 


Thr Met Gly Cys Trp Asp Met Tyr Arg His Asp Ile Asp Cys Gln Trp 
                485                 490                 495     


Val Asp Ile Thr Asp Val Pro Pro Gly Asp Tyr Leu Phe Gln Val Val 
            500                 505                 510         


Ile Asn Pro Asn Phe Glu Val Ala Glu Ser Asp Tyr Ser Asn Asn Ile 
        515                 520                 525             


Met Lys Cys Arg Ser Arg Tyr Asp Gly His Arg Ile Trp Met Tyr Asn 
    530                 535                 540                 


Ser His Ile Gly Gly Ser Phe Ser Glu Glu Thr Glu Lys Lys Phe Glu 
545                 550                 555                 560 


His Phe Ser Gly Leu Leu Asn Asn Gln Leu Ser Pro Pro Val Lys Lys 
                565                 570                 575     


Pro Ala Trp Ser Thr Pro Val Phe Arg Pro His His Ile Phe His Gly 
            580                 585                 590         


Thr Ser Pro Gln Gln Leu Ser Leu Asn Glu Cys His Val Pro Ser Pro 
        595                 600                 605             


Ser Pro Ala Pro Thr Leu Ser Arg Pro Leu Gln Leu Cys Leu Ser Ser 
    610                 615                 620                 


Gly Gly Lys Gly Pro Ser His His Ser Trp Gly Ala Ala Thr 
625                 630                 635             


