                         SEQUENCE LISTING

<110>  COOPER, LAURENCE J
       JENA, BIPULENDU
       SINGH, HARJEET
       RUSHWORTH, DAVID
 
<120>  CHIMERIC ANTIGEN RECEPTOR-TARGETING MONOCLONAL ANTIBODIES

<130>  UTFC.P1221WO

<140>  Unknown
<141>  2014-05-23

<150>  61/827,312
<151>  2013-05-24

<160>  25    

<170>  PatentIn version 3.5

<210>  1
<211>  153
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Antibody sequence

<400>  1

Leu Lys Pro Arg Glu Val Lys Leu Val Glu Ser Gly Gly Gly Leu Val 
1               5                   10                  15      


Gln Pro Gly Gly Ser Leu Lys Leu Ser Cys Ala Ala Ser Gly Phe Asp 
            20                  25                  30          


Phe Ser Arg Tyr Trp Met Ser Trp Val Arg Gln Ala Pro Gly Lys Gly 
        35                  40                  45              


Leu Glu Trp Ile Gly Glu Ile Asn Leu Asp Ser Ser Thr Ile Asn Tyr 
    50                  55                  60                  


Thr Pro Ser Leu Lys Asp Lys Phe Ile Ile Ser Arg Asp Asn Ala Lys 
65                  70                  75                  80  


Asn Thr Leu Tyr Leu Gln Met Ser Lys Val Arg Ser Glu Asp Thr Ala 
                85                  90                  95      


Leu Tyr Tyr Cys Ala Arg Arg Tyr Asp Ala Met Asp Tyr Trp Gly Gln 
            100                 105                 110         


Gly Thr Ser Val Thr Val Ser Ser Ala Lys Thr Thr Ala Pro Ser Val 
        115                 120                 125             


Tyr Pro Leu Ala Pro Val Cys Gly Asp Thr Thr Gly Ser Ser Val Thr 
    130                 135                 140                 


Leu Gly Cys Leu Val Lys Ala Ser Gln 
145                 150             


<210>  2
<211>  8
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Antibody polypeptide

<400>  2

Gly Phe Asp Phe Ser Arg Tyr Trp 
1               5               


<210>  3
<211>  8
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Antibody polypeptide

<400>  3

Ile Asn Leu Asp Ser Ser Thr Ile 
1               5               


<210>  4
<211>  9
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Antibody polypeptide

<400>  4

Ala Arg Arg Tyr Asp Ala Met Asp Tyr 
1               5                   


<210>  5
<211>  111
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Antibody polypeptide

<400>  5

Ala Ser Asp Ile Val Leu Thr Gln Ser Pro Ala Ser Leu Ala Val Ser 
1               5                   10                  15      


Leu Gly Gln Arg Ala Thr Ile Ser Cys Arg Ala Ser Glu Ser Val Asp 
            20                  25                  30          


Asp Tyr Gly Ile Ser Phe Met Asn Trp Phe Gln Gln Lys Pro Gly Gln 
        35                  40                  45              


Pro Pro Lys Leu Leu Ile Tyr Ala Ala Pro Asn Gln Gly Ser Gly Val 
    50                  55                  60                  


Pro Ala Arg Phe Ser Gly Ser Gly Ser Gly Thr Asp Phe Ser Leu Asn 
65                  70                  75                  80  


Ile His Pro Met Glu Glu Asp Asp Thr Ala Met Tyr Phe Cys Gln Gln 
                85                  90                  95      


Ser Lys Asp Val Arg Trp Arg His Gln Ala Gly Asp Gln Thr Gly 
            100                 105                 110     


<210>  6
<211>  10
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Antibody polypeptide

<400>  6

Glu Ser Val Asp Asp Tyr Gly Ile Ser Phe 
1               5                   10  


<210>  7
<211>  3
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Antibody polypeptide

<400>  7

Ala Ala Pro 
1           


<210>  8
<211>  5
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Antibody polypeptide

<400>  8

Gln Gln Ser Lys Asp 
1               5   


<210>  9
<211>  140
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Antibody polypeptide


<220>
<221>  misc_feature
<222>  (4)..(4)
<223>  Xaa can be any naturally occurring amino acid

<400>  9

Pro Arg Glu Xaa Lys Leu Glu Gln Ser Gly Thr Val Leu Ala Arg Pro 
1               5                   10                  15      


Gly Ala Ser Val Lys Met Ser Cys Lys Thr Ser Gly Tyr Thr Phe Thr 
            20                  25                  30          


Ser Tyr Trp Met His Trp Val Ile Gln Arg Pro Gly Gln Gly Leu Glu 
        35                  40                  45              


Trp Ile Gly Ala Ile Tyr Pro Gly Asn Ser Asp Thr Asn Tyr Asn Gln 
    50                  55                  60                  


Lys Phe Lys Val Lys Ala Lys Leu Thr Ala Val Thr Ser Thr Ser Thr 
65                  70                  75                  80  


Ala Tyr Met Glu Leu Ser Ser Leu Thr Asp Glu Asp Ser Ala Val Tyr 
                85                  90                  95      


Tyr Cys Thr Arg Val Asn Trp Asp Gly Tyr Ser Thr Met Asp Tyr Trp 
            100                 105                 110         


Gly Gln Gly Thr Ser Val Thr Val Ser Ser Ala Lys Thr Thr Pro Pro 
        115                 120                 125             


Ser Val Tyr Ala Ser Gln Arg Ala Asn Ser Arg Pro 
    130                 135                 140 


<210>  10
<211>  8
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Antibody polypeptide

<400>  10

Gly Tyr Thr Phe Thr Ser Tyr Trp 
1               5               


<210>  11
<211>  8
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Antibody polypeptide

<400>  11

Ile Tyr Pro Gly Asn Ser Asp Thr 
1               5               


<210>  12
<211>  13
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Antibody polypeptide

<400>  12

Thr Arg Val Asn Trp Asp Gly Tyr Ser Thr Met Asp Tyr 
1               5                   10              


<210>  13
<211>  115
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Antibody polypeptide

<400>  13

Ser Thr Leu Ser Leu Pro Val Ser Leu Gly Asp Gln Ala Ser Ile Ser 
1               5                   10                  15      


Cys Arg Ser Ser Gln Ser Leu Val His Ser Asn Gly Asn Thr Tyr Phe 
            20                  25                  30          


His Trp Tyr Leu Gln Lys Pro Gly Gln Ser Pro Lys Leu Leu Ile Tyr 
        35                  40                  45              


Lys Val Ser Asn Arg Phe Ser Gly Val Pro Asp Arg Phe Ser Gly Ser 
    50                  55                  60                  


Gly Ser Gly Thr Asn Phe Thr Leu Lys Ile Ser Arg Val Glu Ala Glu 
65                  70                  75                  80  


Asp Leu Gly Val Tyr Phe Cys Ser Gln Thr Thr His Val Pro Tyr Thr 
                85                  90                  95      


Phe Gly Gly Gly Thr Glu Leu Glu Ile Lys Arg Ala Asp Ala Ala Pro 
            100                 105                 110         


Thr Val Ser 
        115 


<210>  14
<211>  11
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Antibody polypeptide

<400>  14

Gln Ser Leu Val His Ser Asn Gly Asn Thr Tyr 
1               5                   10      


<210>  15
<211>  3
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Antibody polypeptide

<400>  15

Lys Val Ser 
1           


<210>  16
<211>  11
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Antibody polypeptide

<400>  16

Cys Ser Gln Thr Thr His Val Pro Tyr Thr Phe 
1               5                   10      


<210>  17
<211>  711
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Fusion protein

<400>  17

Met Leu Leu Leu Val Thr Ser Leu Leu Leu Leu Cys Glu Leu Pro His 
1               5                   10                  15      


Pro Ala Phe Leu Leu Ile Pro Asp Ile Gln Met Thr Gln Gln Thr Thr 
            20                  25                  30          


Ser Ser Leu Ser Ala Ser Leu Gly Asp Arg Val Thr Ile Ser Cys Arg 
        35                  40                  45              


Ala Ser Ser Gln Asp Ile Ser Lys Tyr Leu Asn Trp Tyr Gln Gln Lys 
    50                  55                  60                  


Pro Asp Gly Thr Val Lys Leu Leu Leu Ile Tyr His Thr Ser Arg Leu 
65                  70                  75                  80  


His Ser Gly Val Pro Ser Arg Phe Ser Gly Ser Gly Gly Ser Gly Thr 
                85                  90                  95      


Asp Tyr Ser Leu Thr Ile Ser Asn Leu Glu Gln Glu Asp Ile Ala Thr 
            100                 105                 110         


Tyr Tyr Phe Cys Gln Gln Gly Asn Thr Leu Pro Tyr Thr Phe Gly Gly 
        115                 120                 125             


Gly Thr Lys Leu Glu Ile Ile Thr Gly Ser Thr Ser Gly Ser Gly Lys 
    130                 135                 140                 


Pro Gly Ser Gly Glu Gly Ser Thr Lys Gly Glu Glu Val Lys Leu Gln 
145                 150                 155                 160 


Glu Ser Gly Pro Gly Leu Val Ala Pro Ser Gln Ser Leu Ser Val Thr 
                165                 170                 175     


Thr Cys Thr Val Ser Gly Val Ser Leu Pro Asp Tyr Gly Val Ser Trp 
            180                 185                 190         


Ile Arg Gln Pro Pro Pro Arg Lys Gly Leu Glu Trp Leu Gly Val Ile 
        195                 200                 205             


Trp Gly Ser Glu Thr Thr Tyr Tyr Asn Ser Ser Ala Leu Lys Ser Arg 
    210                 215                 220                 


Leu Thr Ile Ile Lys Asp Asn Ser Lys Ser Gln Val Phe Leu Lys Lys 
225                 230                 235                 240 


Met Asn Ser Leu Gln Thr Asp Asp Thr Ala Ile Tyr Tyr Cys Ala Lys 
                245                 250                 255     


His Tyr Tyr Tyr Tyr Gly Gly Ser Tyr Ala Met Asp Tyr Trp Gly Gln 
            260                 265                 270         


Gly Thr Ser Val Thr Val Ser Ser Glu Glu Ser Lys Tyr Gly Pro Pro 
        275                 280                 285             


Cys Pro Pro Cys Pro Ala Pro Glu Phe Leu Gly Gly Pro Ser Ser Val 
    290                 295                 300                 


Phe Leu Phe Pro Pro Lys Pro Lys Asp Thr Leu Met Ile Ser Arg Thr 
305                 310                 315                 320 


Pro Glu Val Val Thr Cys Val Val Val Asp Val Ser Gln Glu Asp Pro 
                325                 330                 335     


Glu Val Gln Phe Asn Trp Tyr Val Val Asp Gly Val Glu Val His Asn 
            340                 345                 350         


Ala Lys Thr Lys Pro Arg Glu Glu Gln Phe Asn Ser Thr Thr Tyr Arg 
        355                 360                 365             


Val Val Ser Val Leu Thr Val Leu His Gln Asp Trp Leu Asn Gly Lys 
    370                 375                 380                 


Glu Tyr Tyr Lys Cys Lys Val Ser Asn Lys Gly Leu Pro Ser Ser Ile 
385                 390                 395                 400 


Glu Lys Thr Ile Ser Lys Ala Ala Lys Gly Gln Pro Arg Glu Pro Gln 
                405                 410                 415     


Val Tyr Thr Leu Pro Pro Ser Gln Glu Glu Met Thr Thr Lys Asn Gln 
            420                 425                 430         


Val Ser Leu Thr Cys Leu Val Lys Gly Phe Tyr Pro Ser Asp Ile Ala 
        435                 440                 445             


Val Val Glu Trp Glu Ser Asn Gly Gln Pro Glu Asn Asn Tyr Lys Thr 
    450                 455                 460                 


Thr Pro Pro Val Leu Asp Asp Ser Asp Gly Ser Phe Phe Leu Tyr Ser 
465                 470                 475                 480 


Arg Leu Thr Val Asp Lys Ser Arg Trp Gln Glu Glu Gly Asn Val Phe 
                485                 490                 495     


Ser Cys Ser Val Met His Glu Ala Leu His Asn His Tyr Thr Gln Lys 
            500                 505                 510         


Lys Ser Leu Ser Leu Ser Leu Gly Lys Met Phe Trp Val Leu Val Val 
        515                 520                 525             


Val Gly Gly Val Leu Leu Ala Cys Tyr Ser Leu Leu Val Thr Val Ala 
    530                 535                 540                 


Phe Ile Ile Phe Trp Val Arg Ser Lys Arg Arg Ser Arg Gly Gly His 
545                 550                 555                 560 


Ser Asp Tyr Met Asn Met Thr Pro Arg Arg Pro Gly Pro Thr Arg Arg 
                565                 570                 575     


Lys His Tyr Gln Pro Tyr Ala Pro Pro Arg Asp Phe Ala Ala Tyr Arg 
            580                 585                 590         


Ser Arg Val Lys Lys Phe Ser Arg Ser Ala Asp Ala Pro Ala Tyr Gln 
        595                 600                 605             


Gln Gly Gln Asn Gln Leu Tyr Asn Glu Glu Leu Asn Leu Gly Arg Arg 
    610                 615                 620                 


Glu Glu Tyr Asp Val Leu Asp Lys Arg Arg Gly Arg Asp Pro Pro Glu 
625                 630                 635                 640 


Met Gly Gly Lys Pro Arg Arg Lys Asn Pro Gln Glu Gly Leu Tyr Asn 
                645                 650                 655     


Glu Leu Gln Gln Lys Asp Lys Met Ala Glu Ala Tyr Ser Glu Ile Gly 
            660                 665                 670         


Met Lys Gly Glu Arg Arg Arg Gly Gly Lys Gly His Asp Gly Leu Tyr 
        675                 680                 685             


Gln Gly Leu Ser Thr Ala Thr Lys Asp Thr Tyr Asp Ala Ala Leu His 
    690                 695                 700                 


Met Gln Ala Leu Pro Pro Arg 
705                 710     


<210>  18
<211>  229
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Fusion protein

<400>  18

Glu Ser Lys Tyr Gly Pro Pro Cys Pro Pro Cys Pro Ala Pro Glu Phe 
1               5                   10                  15      


Leu Gly Gly Pro Ser Val Phe Leu Phe Pro Pro Lys Pro Lys Asp Thr 
            20                  25                  30          


Leu Met Ile Ser Arg Thr Pro Glu Val Thr Cys Val Val Val Asp Val 
        35                  40                  45              


Ser Gln Glu Asp Pro Glu Val Gln Phe Asn Trp Tyr Val Asp Gly Val 
    50                  55                  60                  


Glu Val His Asn Ala Lys Thr Lys Pro Arg Glu Glu Gln Phe Asn Ser 
65                  70                  75                  80  


Thr Tyr Arg Val Val Ser Val Leu Thr Val Leu His Gln Asp Trp Leu 
                85                  90                  95      


Asn Gly Lys Glu Tyr Lys Cys Lys Val Ser Asn Lys Gly Leu Pro Ser 
            100                 105                 110         


Ser Ile Glu Lys Thr Ile Ser Lys Ala Lys Gly Gln Pro Arg Glu Pro 
        115                 120                 125             


Gln Val Tyr Thr Leu Pro Pro Ser Gln Glu Glu Met Thr Lys Asn Gln 
    130                 135                 140                 


Val Ser Leu Thr Cys Leu Val Lys Gly Phe Tyr Pro Ser Asp Ile Ala 
145                 150                 155                 160 


Val Glu Trp Glu Ser Asn Gly Gln Pro Glu Asn Asn Tyr Lys Thr Thr 
                165                 170                 175     


Pro Pro Val Leu Asp Ser Asp Gly Ser Phe Phe Leu Tyr Ser Arg Leu 
            180                 185                 190         


Thr Val Asp Lys Ser Arg Trp Gln Glu Gly Asn Val Phe Ser Cys Ser 
        195                 200                 205             


Val Met His Glu Ala Leu His Asn His Tyr Thr Gln Lys Ser Leu Ser 
    210                 215                 220                 


Leu Ser Leu Gly Lys 
225                 


<210>  19
<211>  28
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic polypeptide

<400>  19

Met Glu Thr Asp Thr Leu Leu Leu Trp Val Leu Leu Leu Trp Val Pro 
1               5                   10                  15      


Gly Ser Thr Gly Asp Tyr Lys Asp Glu Gly Thr Ser 
            20                  25              


<210>  20
<211>  28
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic primer

<400>  20
ggtacctctg gggggcaggg cctgcatg                                          28


<210>  21
<211>  33
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic primer

<400>  21
gggcccagcg ctgagagcaa gtacggccct ccc                                    33


<210>  22
<211>  233
<212>  PRT
<213>  Homo sapiens

<400>  22

Met Leu Leu Leu Val Thr Ser Leu Leu Leu Cys Glu Leu Pro His Pro 
1               5                   10                  15      


Ala Phe Leu Leu Ile Pro Glu Lys Ser Asp Leu Arg Thr Val Ala Pro 
            20                  25                  30          


Ala Ser Ser Leu Asn Val Arg Phe Asp Ser Arg Thr Met Asn Leu Ser 
        35                  40                  45              


Trp Asp Cys Gln Glu Asn Thr Thr Phe Ser Lys Cys Phe Leu Thr Asp 
    50                  55                  60                  


Lys Lys Asn Arg Val Val Glu Pro Arg Leu Ser Asn Asn Glu Cys Ser 
65                  70                  75                  80  


Cys Thr Phe Arg Glu Ile Cys Leu His Glu Gly Val Thr Phe Glu Val 
                85                  90                  95      


His Val Asn Thr Ser Gln Arg Gly Phe Gln Gln Lys Leu Leu Tyr Pro 
            100                 105                 110         


Asn Ser Gly Arg Glu Gly Thr Ala Ala Gln Asn Phe Ser Cys Phe Ile 
        115                 120                 125             


Tyr Asn Ala Asp Leu Met Asn Cys Thr Trp Ala Arg Gly Pro Thr Ala 
    130                 135                 140                 


Pro Arg Asp Val Gln Tyr Phe Leu Tyr Ile Arg Asn Ser Lys Arg Arg 
145                 150                 155                 160 


Arg Glu Ile Arg Cys Pro Tyr Tyr Ile Gln Asp Ser Gly Thr His Val 
                165                 170                 175     


Gly Cys His Leu Asp Asn Leu Ser Gly Leu Thr Ser Arg Asn Tyr Phe 
            180                 185                 190         


Leu Val Asn Gly Thr Ser Arg Glu Ile Gly Ile Gln Phe Phe Asp Ser 
        195                 200                 205             


Leu Leu Asp Thr Lys Lys Ile Gly Ser Leu Gly Tyr Ser Gly Cys Ser 
    210                 215                 220                 


Arg Gln Phe His Arg Ser Lys Thr Asn 
225                 230             


<210>  23
<211>  235
<212>  PRT
<213>  Homo sapiens

<400>  23

Met Ala Leu Pro Val Thr Ala Leu Leu Leu Pro Leu Ala Leu Leu Leu 
1               5                   10                  15      


His Ala Ala Arg Pro Ser Gln Phe Arg Val Ser Pro Leu Asp Arg Thr 
            20                  25                  30          


Trp Asn Leu Gly Glu Thr Val Glu Leu Lys Cys Gln Val Leu Leu Ser 
        35                  40                  45              


Asn Pro Thr Ser Gly Cys Ser Trp Leu Phe Gln Pro Arg Gly Ala Ala 
    50                  55                  60                  


Ala Ser Pro Thr Phe Leu Leu Tyr Leu Ser Gln Asn Lys Pro Lys Ala 
65                  70                  75                  80  


Ala Glu Gly Leu Asp Thr Gln Arg Phe Ser Gly Lys Arg Leu Gly Asp 
                85                  90                  95      


Thr Phe Val Leu Thr Leu Ser Asp Phe Arg Arg Glu Asn Glu Gly Tyr 
            100                 105                 110         


Tyr Phe Cys Ser Ala Leu Ser Asn Ser Ile Met Tyr Phe Ser His Phe 
        115                 120                 125             


Val Pro Val Phe Leu Pro Ala Lys Pro Thr Thr Thr Pro Ala Pro Arg 
    130                 135                 140                 


Pro Pro Thr Pro Ala Pro Thr Ile Ala Ser Gln Pro Leu Ser Leu Arg 
145                 150                 155                 160 


Pro Glu Ala Cys Arg Pro Ala Ala Gly Gly Ala Val His Thr Arg Gly 
                165                 170                 175     


Leu Asp Phe Ala Cys Asp Ile Tyr Ile Trp Ala Pro Leu Ala Gly Thr 
            180                 185                 190         


Cys Gly Val Leu Leu Leu Ser Leu Val Ile Thr Leu Tyr Cys Asn His 
        195                 200                 205             


Arg Asn Arg Arg Arg Val Cys Lys Cys Pro Arg Pro Val Val Lys Ser 
    210                 215                 220                 


Gly Asp Lys Pro Ser Leu Ser Ala Arg Tyr Val 
225                 230                 235 


<210>  24
<211>  123
<212>  PRT
<213>  Homo sapiens

<400>  24

Met Leu Arg Leu Leu Leu Ala Leu Asn Leu Phe Pro Ser Ile Gln Val 
1               5                   10                  15      


Thr Gly Asn Lys Ile Leu Val Lys Gln Ser Pro Met Leu Val Ala Tyr 
            20                  25                  30          


Asp Asn Ala Val Asn Leu Ser Trp Lys His Leu Cys Pro Ser Pro Leu 
        35                  40                  45              


Phe Pro Gly Pro Ser Lys Pro Phe Trp Val Leu Val Val Val Gly Gly 
    50                  55                  60                  


Val Leu Ala Cys Tyr Ser Leu Leu Val Thr Val Ala Phe Ile Ile Phe 
65                  70                  75                  80  


Trp Val Arg Ser Lys Arg Ser Arg Leu Leu His Ser Asp Tyr Met Asn 
                85                  90                  95      


Met Thr Pro Arg Arg Pro Gly Pro Thr Arg Lys His Tyr Gln Pro Tyr 
            100                 105                 110         


Ala Pro Pro Arg Asp Phe Ala Ala Tyr Arg Ser 
        115                 120             


<210>  25
<211>  163
<212>  PRT
<213>  Homo sapiens

<400>  25

Met Lys Trp Lys Ala Leu Phe Thr Ala Ala Ile Leu Gln Ala Gln Leu 
1               5                   10                  15      


Pro Ile Thr Glu Ala Gln Ser Phe Gly Leu Leu Asp Pro Lys Leu Cys 
            20                  25                  30          


Tyr Leu Leu Asp Gly Ile Leu Phe Ile Tyr Gly Val Ile Leu Thr Ala 
        35                  40                  45              


Leu Phe Leu Arg Val Lys Phe Ser Arg Ser Ala Asp Ala Pro Ala Tyr 
    50                  55                  60                  


Gln Gln Gly Gln Asn Gln Leu Tyr Asn Glu Leu Asn Leu Gly Arg Arg 
65                  70                  75                  80  


Glu Glu Tyr Asp Val Leu Asp Lys Arg Arg Gly Arg Asp Pro Glu Met 
                85                  90                  95      


Gly Gly Lys Pro Arg Arg Lys Asn Pro Gln Glu Gly Leu Tyr Asn Glu 
            100                 105                 110         


Leu Gln Lys Asp Lys Met Ala Glu Ala Tyr Ser Glu Ile Gly Met Lys 
        115                 120                 125             


Gly Glu Arg Arg Arg Gly Lys Gly His Asp Gly Leu Tyr Gln Gly Leu 
    130                 135                 140                 


Ser Thr Ala Thr Lys Asp Thr Tyr Asp Ala Leu His Met Gln Ala Leu 
145                 150                 155                 160 


Pro Pro Arg 
            


