                               SEQUENCE LISTING

<110> HARVARD UNIVERSITY
 
<120> HEMOPEXIN FUSIONS FOR THE TREATMENT OF SEPSIS

<130> 002806-076881-PCT

<140>
<141>

<150> 61/825,707
<151> 2013-05-21

<160> 18     

<170> PatentIn version 3.5

<210> 1
<211> 462
<212> PRT
<213> Homo sapiens

<400> 1
Met Ala Arg Val Leu Gly Ala Pro Val Ala Leu Gly Leu Trp Ser Leu 
1               5                   10                  15      


Cys Trp Ser Leu Ala Ile Ala Thr Pro Leu Pro Pro Thr Ser Ala His 
            20                  25                  30          


Gly Asn Val Ala Glu Gly Glu Thr Lys Pro Asp Pro Asp Val Thr Glu 
        35                  40                  45              


Arg Cys Ser Asp Gly Trp Ser Phe Asp Ala Thr Thr Leu Asp Asp Asn 
    50                  55                  60                  


Gly Thr Met Leu Phe Phe Lys Gly Glu Phe Val Trp Lys Ser His Lys 
65                  70                  75                  80  


Trp Asp Arg Glu Leu Ile Ser Glu Arg Trp Lys Asn Phe Pro Ser Pro 
                85                  90                  95      


Val Asp Ala Ala Phe Arg Gln Gly His Asn Ser Val Phe Leu Ile Lys 
            100                 105                 110         


Gly Asp Lys Val Trp Val Tyr Pro Pro Glu Lys Lys Glu Lys Gly Tyr 
        115                 120                 125             


Pro Lys Leu Leu Gln Asp Glu Phe Pro Gly Ile Pro Ser Pro Leu Asp 
    130                 135                 140                 


Ala Ala Val Glu Cys His Arg Gly Glu Cys Gln Ala Glu Gly Val Leu 
145                 150                 155                 160 


Phe Phe Gln Gly Asp Arg Glu Trp Phe Trp Asp Leu Ala Thr Gly Thr 
                165                 170                 175     


Met Lys Glu Arg Ser Trp Pro Ala Val Gly Asn Cys Ser Ser Ala Leu 
            180                 185                 190         


Arg Trp Leu Gly Arg Tyr Tyr Cys Phe Gln Gly Asn Gln Phe Leu Arg 
        195                 200                 205             


Phe Asp Pro Val Arg Gly Glu Val Pro Pro Arg Tyr Pro Arg Asp Val 
    210                 215                 220                 


Arg Asp Tyr Phe Met Pro Cys Pro Gly Arg Gly His Gly His Arg Asn 
225                 230                 235                 240 


Gly Thr Gly His Gly Asn Ser Thr His His Gly Pro Glu Tyr Met Arg 
                245                 250                 255     


Cys Ser Pro His Leu Val Leu Ser Ala Leu Thr Ser Asp Asn His Gly 
            260                 265                 270         


Ala Thr Tyr Ala Phe Ser Gly Thr His Tyr Trp Arg Leu Asp Thr Ser 
        275                 280                 285             


Arg Asp Gly Trp His Ser Trp Pro Ile Ala His Gln Trp Pro Gln Gly 
    290                 295                 300                 


Pro Ser Ala Val Asp Ala Ala Phe Ser Trp Glu Glu Lys Leu Tyr Leu 
305                 310                 315                 320 


Val Gln Gly Thr Gln Val Tyr Val Phe Leu Thr Lys Gly Gly Tyr Thr 
                325                 330                 335     


Leu Val Ser Gly Tyr Pro Lys Arg Leu Glu Lys Glu Val Gly Thr Pro 
            340                 345                 350         


His Gly Ile Ile Leu Asp Ser Val Asp Ala Ala Phe Ile Cys Pro Gly 
        355                 360                 365             


Ser Ser Arg Leu His Ile Met Ala Gly Arg Arg Leu Trp Trp Leu Asp 
    370                 375                 380                 


Leu Lys Ser Gly Ala Gln Ala Thr Trp Thr Glu Leu Pro Trp Pro His 
385                 390                 395                 400 


Glu Lys Val Asp Gly Ala Leu Cys Met Glu Lys Ser Leu Gly Pro Asn 
                405                 410                 415     


Ser Cys Ser Ala Asn Gly Pro Gly Leu Tyr Leu Ile His Gly Pro Asn 
            420                 425                 430         


Leu Tyr Cys Tyr Ser Asp Val Glu Lys Leu Asn Ala Ala Lys Ala Leu 
        435                 440                 445             


Pro Gln Pro Gln Asn Val Thr Ser Leu Leu Gly Cys Thr His 
    450                 455                 460         


<210> 2
<211> 233
<212> PRT
<213> Homo sapiens

<400> 2
Thr Pro Leu Pro Pro Thr Ser Ala His Gly Asn Val Ala Glu Gly Glu 
1               5                   10                  15      


Thr Lys Pro Asp Pro Asp Val Thr Glu Arg Cys Ser Asp Gly Trp Ser 
            20                  25                  30          


Phe Asp Ala Thr Thr Leu Asp Asp Asn Gly Thr Met Leu Phe Phe Lys 
        35                  40                  45              


Gly Glu Phe Val Trp Lys Ser His Lys Trp Asp Arg Glu Leu Ile Ser 
    50                  55                  60                  


Glu Arg Trp Lys Asn Phe Pro Ser Pro Val Asp Ala Ala Phe Arg Gln 
65                  70                  75                  80  


Gly His Asn Ser Val Phe Leu Ile Lys Gly Asp Lys Val Trp Val Tyr 
                85                  90                  95      


Pro Pro Glu Lys Lys Glu Lys Gly Tyr Pro Lys Leu Leu Gln Asp Glu 
            100                 105                 110         


Phe Pro Gly Ile Pro Ser Pro Leu Asp Ala Ala Val Glu Cys His Arg 
        115                 120                 125             


Gly Glu Cys Gln Ala Glu Gly Val Leu Phe Phe Gln Gly Asp Arg Glu 
    130                 135                 140                 


Trp Phe Trp Asp Leu Ala Thr Gly Thr Met Lys Glu Arg Ser Trp Pro 
145                 150                 155                 160 


Ala Val Gly Asn Cys Ser Ser Ala Leu Arg Trp Leu Gly Arg Tyr Tyr 
                165                 170                 175     


Cys Phe Gln Gly Asn Gln Phe Leu Arg Phe Asp Pro Val Arg Gly Glu 
            180                 185                 190         


Val Pro Pro Arg Tyr Pro Arg Asp Val Arg Asp Tyr Phe Met Pro Cys 
        195                 200                 205             


Pro Gly Arg Gly His Gly His Arg Asn Gly Thr Gly His Gly Asn Ser 
    210                 215                 220                 


Thr His His Gly Pro Glu Tyr Met Arg 
225                 230             


<210> 3
<211> 674
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      polypeptide

<400> 3
Ala Lys Thr Glu Pro Lys Ser Ser Asp Lys Thr His Thr Cys Pro Pro 
1               5                   10                  15      


Cys Pro Ala Pro Glu Leu Leu Gly Gly Pro Ser Val Phe Leu Phe Pro 
            20                  25                  30          


Pro Lys Pro Lys Asp Thr Leu Met Ile Ser Arg Thr Pro Glu Val Thr 
        35                  40                  45              


Cys Val Val Val Asp Val Ser His Glu Asp Pro Glu Val Lys Phe Asn 
    50                  55                  60                  


Trp Tyr Val Asp Gly Val Glu Val His Asn Ala Lys Thr Lys Pro Arg 
65                  70                  75                  80  


Glu Glu Gln Tyr Asp Ser Thr Tyr Arg Val Val Ser Val Leu Thr Val 
                85                  90                  95      


Leu His Gln Asp Trp Leu Asn Gly Lys Glu Tyr Lys Cys Lys Val Ser 
            100                 105                 110         


Asn Lys Ala Leu Pro Ala Pro Ile Glu Lys Thr Ile Ser Lys Ala Lys 
        115                 120                 125             


Gly Gln Pro Arg Glu Pro Gln Val Tyr Thr Leu Pro Pro Ser Arg Asp 
    130                 135                 140                 


Glu Leu Thr Lys Asn Gln Val Ser Leu Thr Cys Leu Val Lys Gly Phe 
145                 150                 155                 160 


Tyr Pro Ser Asp Ile Ala Val Glu Trp Glu Ser Asn Gly Gln Pro Glu 
                165                 170                 175     


Asn Asn Tyr Lys Thr Thr Pro Pro Val Leu Asp Ser Asp Gly Ser Phe 
            180                 185                 190         


Phe Leu Tyr Ser Lys Leu Thr Val Asp Lys Ser Arg Trp Gln Gln Gly 
        195                 200                 205             


Asn Val Phe Ser Cys Ser Val Met His Glu Ala Leu His Asn His Tyr 
    210                 215                 220                 


Thr Gln Lys Ser Leu Ser Leu Ser Pro Gly Ala Thr Pro Leu Pro Pro 
225                 230                 235                 240 


Thr Ser Ala His Gly Asn Val Ala Glu Gly Glu Thr Lys Pro Asp Pro 
                245                 250                 255     


Asp Val Thr Glu Arg Cys Ser Asp Gly Trp Ser Phe Asp Ala Thr Thr 
            260                 265                 270         


Leu Asp Asp Asn Gly Thr Met Leu Phe Phe Lys Gly Glu Phe Val Trp 
        275                 280                 285             


Lys Ser His Lys Trp Asp Arg Glu Leu Ile Ser Glu Arg Trp Lys Asn 
    290                 295                 300                 


Phe Pro Ser Pro Val Asp Ala Ala Phe Arg Gln Gly His Asn Ser Val 
305                 310                 315                 320 


Phe Leu Ile Lys Gly Asp Lys Val Trp Val Tyr Pro Pro Glu Lys Lys 
                325                 330                 335     


Glu Lys Gly Tyr Pro Lys Leu Leu Gln Asp Glu Phe Pro Gly Ile Pro 
            340                 345                 350         


Ser Pro Leu Asp Ala Ala Val Glu Cys His Arg Gly Glu Cys Gln Ala 
        355                 360                 365             


Glu Gly Val Leu Phe Phe Gln Gly Asp Arg Glu Trp Phe Trp Asp Leu 
    370                 375                 380                 


Ala Thr Gly Thr Met Lys Glu Arg Ser Trp Pro Ala Val Gly Asn Cys 
385                 390                 395                 400 


Ser Ser Ala Leu Arg Trp Leu Gly Arg Tyr Tyr Cys Phe Gln Gly Asn 
                405                 410                 415     


Gln Phe Leu Arg Phe Asp Pro Val Arg Gly Glu Val Pro Pro Arg Tyr 
            420                 425                 430         


Pro Arg Asp Val Arg Asp Tyr Phe Met Pro Cys Pro Gly Arg Gly His 
        435                 440                 445             


Gly His Arg Asn Gly Thr Gly His Gly Asn Ser Thr His His Gly Pro 
    450                 455                 460                 


Glu Tyr Met Arg Cys Ser Pro His Leu Val Leu Ser Ala Leu Thr Ser 
465                 470                 475                 480 


Asp Asn His Gly Ala Thr Tyr Ala Phe Ser Gly Thr His Tyr Trp Arg 
                485                 490                 495     


Leu Asp Thr Ser Arg Asp Gly Trp His Ser Trp Pro Ile Ala His Gln 
            500                 505                 510         


Trp Pro Gln Gly Pro Ser Ala Val Asp Ala Ala Phe Ser Trp Glu Glu 
        515                 520                 525             


Lys Leu Tyr Leu Val Gln Gly Thr Gln Val Tyr Val Phe Leu Thr Lys 
    530                 535                 540                 


Gly Gly Tyr Thr Leu Val Ser Gly Tyr Pro Lys Arg Leu Glu Lys Glu 
545                 550                 555                 560 


Val Gly Thr Pro His Gly Ile Ile Leu Asp Ser Val Asp Ala Ala Phe 
                565                 570                 575     


Ile Cys Pro Gly Ser Ser Arg Leu His Ile Met Ala Gly Arg Arg Leu 
            580                 585                 590         


Trp Trp Leu Asp Leu Lys Ser Gly Ala Gln Ala Thr Trp Thr Glu Leu 
        595                 600                 605             


Pro Trp Pro His Glu Lys Val Asp Gly Ala Leu Cys Met Glu Lys Ser 
    610                 615                 620                 


Leu Gly Pro Asn Ser Cys Ser Ala Asn Gly Pro Gly Leu Tyr Leu Ile 
625                 630                 635                 640 


His Gly Pro Asn Leu Tyr Cys Tyr Ser Asp Val Glu Lys Leu Asn Ala 
                645                 650                 655     


Ala Lys Ala Leu Pro Gln Pro Gln Asn Val Thr Ser Leu Leu Gly Cys 
            660                 665                 670         


Thr His 
        


<210> 4
<211> 468
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      polypeptide

<400> 4
Ala Lys Thr Glu Pro Lys Ser Ser Asp Lys Thr His Thr Cys Pro Pro 
1               5                   10                  15      


Cys Pro Ala Pro Glu Leu Leu Gly Gly Pro Ser Val Phe Leu Phe Pro 
            20                  25                  30          


Pro Lys Pro Lys Asp Thr Leu Met Ile Ser Arg Thr Pro Glu Val Thr 
        35                  40                  45              


Cys Val Val Val Asp Val Ser His Glu Asp Pro Glu Val Lys Phe Asn 
    50                  55                  60                  


Trp Tyr Val Asp Gly Val Glu Val His Asn Ala Lys Thr Lys Pro Arg 
65                  70                  75                  80  


Glu Glu Gln Tyr Asp Ser Thr Tyr Arg Val Val Ser Val Leu Thr Val 
                85                  90                  95      


Leu His Gln Asp Trp Leu Asn Gly Lys Glu Tyr Lys Cys Lys Val Ser 
            100                 105                 110         


Asn Lys Ala Leu Pro Ala Pro Ile Glu Lys Thr Ile Ser Lys Ala Lys 
        115                 120                 125             


Gly Gln Pro Arg Glu Pro Gln Val Tyr Thr Leu Pro Pro Ser Arg Asp 
    130                 135                 140                 


Glu Leu Thr Lys Asn Gln Val Ser Leu Thr Cys Leu Val Lys Gly Phe 
145                 150                 155                 160 


Tyr Pro Ser Asp Ile Ala Val Glu Trp Glu Ser Asn Gly Gln Pro Glu 
                165                 170                 175     


Asn Asn Tyr Lys Thr Thr Pro Pro Val Leu Asp Ser Asp Gly Ser Phe 
            180                 185                 190         


Phe Leu Tyr Ser Lys Leu Thr Val Asp Lys Ser Arg Trp Gln Gln Gly 
        195                 200                 205             


Asn Val Phe Ser Cys Ser Val Met His Glu Ala Leu His Asn His Tyr 
    210                 215                 220                 


Thr Gln Lys Ser Leu Ser Leu Ser Pro Gly Ala Thr Pro Leu Pro Pro 
225                 230                 235                 240 


Thr Ser Ala His Gly Asn Val Ala Glu Gly Glu Thr Lys Pro Asp Pro 
                245                 250                 255     


Asp Val Thr Glu Arg Cys Ser Asp Gly Trp Ser Phe Asp Ala Thr Thr 
            260                 265                 270         


Leu Asp Asp Asn Gly Thr Met Leu Phe Phe Lys Gly Glu Phe Val Trp 
        275                 280                 285             


Lys Ser His Lys Trp Asp Arg Glu Leu Ile Ser Glu Arg Trp Lys Asn 
    290                 295                 300                 


Phe Pro Ser Pro Val Asp Ala Ala Phe Arg Gln Gly His Asn Ser Val 
305                 310                 315                 320 


Phe Leu Ile Lys Gly Asp Lys Val Trp Val Tyr Pro Pro Glu Lys Lys 
                325                 330                 335     


Glu Lys Gly Tyr Pro Lys Leu Leu Gln Asp Glu Phe Pro Gly Ile Pro 
            340                 345                 350         


Ser Pro Leu Asp Ala Ala Val Glu Cys His Arg Gly Glu Cys Gln Ala 
        355                 360                 365             


Glu Gly Val Leu Phe Phe Gln Gly Asp Arg Glu Trp Phe Trp Asp Leu 
    370                 375                 380                 


Ala Thr Gly Thr Met Lys Glu Arg Ser Trp Pro Ala Val Gly Asn Cys 
385                 390                 395                 400 


Ser Ser Ala Leu Arg Trp Leu Gly Arg Tyr Tyr Cys Phe Gln Gly Asn 
                405                 410                 415     


Gln Phe Leu Arg Phe Asp Pro Val Arg Gly Glu Val Pro Pro Arg Tyr 
            420                 425                 430         


Pro Arg Asp Val Arg Asp Tyr Phe Met Pro Cys Pro Gly Arg Gly His 
        435                 440                 445             


Gly His Arg Asn Gly Thr Gly His Gly Asn Ser Thr His His Gly Pro 
    450                 455                 460                 


Glu Tyr Met Arg 
465             


<210> 5
<211> 465
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      polypeptide

<400> 5
Glu Pro Lys Ser Ser Asp Lys Thr His Thr Cys Pro Pro Cys Pro Ala 
1               5                   10                  15      


Pro Glu Leu Leu Gly Gly Pro Ser Val Phe Leu Phe Pro Pro Lys Pro 
            20                  25                  30          


Lys Asp Thr Leu Met Ile Ser Arg Thr Pro Glu Val Thr Cys Val Val 
        35                  40                  45              


Val Asp Val Ser His Glu Asp Pro Glu Val Lys Phe Asn Trp Tyr Val 
    50                  55                  60                  


Asp Gly Val Glu Val His Asn Ala Lys Thr Lys Pro Arg Glu Glu Gln 
65                  70                  75                  80  


Tyr Asp Ser Thr Tyr Arg Val Val Ser Val Leu Thr Val Leu His Gln 
                85                  90                  95      


Asp Trp Leu Asn Gly Lys Glu Tyr Lys Cys Lys Val Ser Asn Lys Ala 
            100                 105                 110         


Leu Pro Ala Pro Ile Glu Lys Thr Ile Ser Lys Ala Lys Gly Gln Pro 
        115                 120                 125             


Arg Glu Pro Gln Val Tyr Thr Leu Pro Pro Ser Arg Asp Glu Leu Thr 
    130                 135                 140                 


Lys Asn Gln Val Ser Leu Thr Cys Leu Val Lys Gly Phe Tyr Pro Ser 
145                 150                 155                 160 


Asp Ile Ala Val Glu Trp Glu Ser Asn Gly Gln Pro Glu Asn Asn Tyr 
                165                 170                 175     


Lys Thr Thr Pro Pro Val Leu Asp Ser Asp Gly Ser Phe Phe Leu Tyr 
            180                 185                 190         


Ser Lys Leu Thr Val Asp Lys Ser Arg Trp Gln Gln Gly Asn Val Phe 
        195                 200                 205             


Ser Cys Ser Val Met His Glu Ala Leu His Asn His Tyr Thr Gln Lys 
    210                 215                 220                 


Ser Leu Ser Leu Ser Pro Gly Ala Thr Pro Leu Pro Pro Thr Ser Ala 
225                 230                 235                 240 


His Gly Asn Val Ala Glu Gly Glu Thr Lys Pro Asp Pro Asp Val Thr 
                245                 250                 255     


Glu Arg Cys Ser Asp Gly Trp Ser Phe Asp Ala Thr Thr Leu Asp Asp 
            260                 265                 270         


Asn Gly Thr Met Leu Phe Phe Lys Gly Glu Phe Val Trp Lys Ser His 
        275                 280                 285             


Lys Trp Asp Arg Glu Leu Ile Ser Glu Arg Trp Lys Asn Phe Pro Ser 
    290                 295                 300                 


Pro Val Asp Ala Ala Phe Arg Gln Gly His Asn Ser Val Phe Leu Ile 
305                 310                 315                 320 


Lys Gly Asp Lys Val Trp Val Tyr Pro Pro Glu Lys Lys Glu Lys Gly 
                325                 330                 335     


Tyr Pro Lys Leu Leu Gln Asp Glu Phe Pro Gly Ile Pro Ser Pro Leu 
            340                 345                 350         


Asp Ala Ala Val Glu Cys His Arg Gly Glu Cys Gln Ala Glu Gly Val 
        355                 360                 365             


Leu Phe Phe Gln Gly Asp Arg Glu Trp Phe Trp Asp Leu Ala Thr Gly 
    370                 375                 380                 


Thr Met Lys Glu Arg Ser Trp Pro Ala Val Gly Asn Cys Ser Ser Ala 
385                 390                 395                 400 


Leu Arg Trp Leu Gly Arg Tyr Tyr Cys Phe Gln Gly Asn Gln Phe Leu 
                405                 410                 415     


Arg Phe Asp Pro Val Arg Gly Glu Val Pro Pro Arg Tyr Pro Arg Asp 
            420                 425                 430         


Val Arg Asp Tyr Phe Met Pro Cys Pro Gly Arg Gly His Gly His Arg 
        435                 440                 445             


Asn Gly Thr Gly His Gly Asn Ser Thr His His Gly Pro Glu Tyr Met 
    450                 455                 460                 


Arg 
465 


<210> 6
<211> 1635
<212> DNA
<213> Homo sapiens

<400> 6
aactctatat agggagttca actggtcacc cagagctgtc ctgtggcctc tgcagctcag       60

catggctagg gtactgggag cacccgttgc actggggttg tggagcctat gctggtctct      120

ggccattgcc acccctcttc ctccgactag tgcccatggg aatgttgctg aaggcgagac      180

caagccagac ccagacgtga ctgaacgctg ctcagatggc tggagctttg atgctaccac      240

cctggatgac aatggaacca tgctgttttt taaaggggag tttgtgtgga agagtcacaa      300

atgggaccgg gagttaatct cagagagatg gaagaatttc cccagccctg tggatgctgc      360

attccgtcaa ggtcacaaca gtgtctttct gatcaagggg gacaaagtct gggtataccc      420

tcctgaaaag aaggagaaag gatacccaaa gttgctccaa gatgaatttc ctggaatccc      480

atccccactg gatgcagctg tggaatgtca ccgtggagaa tgtcaagctg aaggcgtcct      540

cttcttccaa ggtgaccgcg agtggttctg ggacttggct acgggaacca tgaaggagcg      600

ttcctggcca gctgttggga actgctcctc tgccctgaga tggctgggcc gctactactg      660

cttccagggt aaccaattcc tgcgcttcga ccctgtcagg ggagaggtgc ctcccaggta      720

cccgcgggat gtccgagact acttcatgcc ctgccctggc agaggccatg gacacaggaa      780

tgggactggc catgggaaca gtacccacca tggccctgag tatatgcgct gtagcccaca      840

tctagtcttg tctgcactga cgtctgacaa ccatggtgcc acctatgcct tcagtgggac      900

ccactactgg cgtctggaca ccagccggga tggctggcat agctggccca ttgctcatca      960

gtggccccag ggtccttcag cagtggatgc tgccttttcc tgggaagaaa aactctatct     1020

ggtccagggc acccaggtat atgtcttcct gacaaaggga ggctataccc tagtaagcgg     1080

ttatccgaag cggctggaga aggaagtcgg gacccctcat gggattatcc tggactctgt     1140

ggatgcggcc tttatctgcc ctgggtcttc tcggctccat atcatggcag gacggcggct     1200

gtggtggctg gacctgaagt caggagccca agccacgtgg acagagcttc cttggcccca     1260

tgagaaggta gacggagcct tgtgtatgga aaagtccctt ggccctaact catgttccgc     1320

caatggtccc ggcttgtacc tcatccatgg tcccaatttg tactgctaca gtgatgtgga     1380

gaaactgaat gcagccaagg cccttccgca accccagaat gtgaccagtc tcctgggctg     1440

cactcactga ggggccttct gacatgagtc tggcctggcc ccacctccta gttcctcata     1500

ataaagacag attgcttctt cgcttctcac tgaggggcct tctgacatga gtctggcctg     1560

gccccacctc cccagtttct cataataaag acagattgct tcttcacttg aatcaaggga     1620

cctaaaaaaa aaaaa                                                      1635


<210> 7
<211> 231
<212> PRT
<213> Homo sapiens

<400> 7
Glu Pro Lys Ser Ser Asp Lys Thr His Thr Cys Pro Pro Cys Pro Ala 
1               5                   10                  15      


Pro Glu Leu Leu Gly Gly Pro Ser Val Phe Leu Phe Pro Pro Lys Pro 
            20                  25                  30          


Lys Asp Thr Leu Met Ile Ser Arg Thr Pro Glu Val Thr Cys Val Val 
        35                  40                  45              


Val Asp Val Ser His Glu Asp Pro Glu Val Lys Phe Asn Trp Tyr Val 
    50                  55                  60                  


Asp Gly Val Glu Val His Asn Ala Lys Thr Lys Pro Arg Glu Glu Gln 
65                  70                  75                  80  


Tyr Asp Ser Thr Tyr Arg Val Val Ser Val Leu Thr Val Leu His Gln 
                85                  90                  95      


Asp Trp Leu Asn Gly Lys Glu Tyr Lys Cys Lys Val Ser Asn Lys Ala 
            100                 105                 110         


Leu Pro Ala Pro Ile Glu Lys Thr Ile Ser Lys Ala Lys Gly Gln Pro 
        115                 120                 125             


Arg Glu Pro Gln Val Tyr Thr Leu Pro Pro Ser Arg Asp Glu Leu Thr 
    130                 135                 140                 


Lys Asn Gln Val Ser Leu Thr Cys Leu Val Lys Gly Phe Tyr Pro Ser 
145                 150                 155                 160 


Asp Ile Ala Val Glu Trp Glu Ser Asn Gly Gln Pro Glu Asn Asn Tyr 
                165                 170                 175     


Lys Thr Thr Pro Pro Val Leu Asp Ser Asp Gly Ser Phe Phe Leu Tyr 
            180                 185                 190         


Ser Lys Leu Thr Val Asp Lys Ser Arg Trp Gln Gln Gly Asn Val Phe 
        195                 200                 205             


Ser Cys Ser Val Met His Glu Ala Leu His Asn His Tyr Thr Gln Lys 
    210                 215                 220                 


Ser Leu Ser Leu Ser Pro Gly 
225                 230     


<210> 8
<211> 231
<212> PRT
<213> Homo sapiens

<400> 8
Glu Pro Lys Ser Ser Asp Lys Thr His Thr Cys Pro Pro Cys Pro Ala 
1               5                   10                  15      


Pro Glu Leu Leu Gly Gly Pro Ser Val Phe Leu Phe Pro Pro Lys Pro 
            20                  25                  30          


Lys Asp Thr Leu Met Ile Ser Arg Thr Pro Glu Val Thr Cys Val Val 
        35                  40                  45              


Val Asp Val Ser His Glu Asp Pro Glu Val Lys Phe Asn Trp Tyr Val 
    50                  55                  60                  


Asp Gly Val Glu Val His Asn Ala Lys Thr Lys Pro Arg Glu Glu Gln 
65                  70                  75                  80  


Tyr Asn Ser Thr Tyr Arg Val Val Ser Val Leu Thr Val Leu His Gln 
                85                  90                  95      


Asp Trp Leu Asn Gly Lys Glu Tyr Lys Cys Lys Val Ser Asn Lys Ala 
            100                 105                 110         


Leu Pro Ala Pro Ile Glu Lys Thr Ile Ser Lys Ala Lys Gly Gln Pro 
        115                 120                 125             


Arg Glu Pro Gln Val Tyr Thr Leu Pro Pro Ser Arg Asp Glu Leu Thr 
    130                 135                 140                 


Lys Asn Gln Val Ser Leu Thr Cys Leu Val Lys Gly Phe Tyr Pro Ser 
145                 150                 155                 160 


Asp Ile Ala Val Glu Trp Glu Ser Asn Gly Gln Pro Glu Asn Asn Tyr 
                165                 170                 175     


Lys Thr Thr Pro Pro Val Leu Asp Ser Asp Gly Ser Phe Phe Leu Tyr 
            180                 185                 190         


Ser Lys Leu Thr Val Asp Lys Ser Arg Trp Gln Gln Gly Asn Val Phe 
        195                 200                 205             


Ser Cys Ser Val Met His Glu Ala Leu His Asn His Tyr Thr Gln Lys 
    210                 215                 220                 


Ser Leu Ser Leu Ser Pro Gly 
225                 230     


<210> 9
<211> 233
<212> PRT
<213> Homo sapiens

<400> 9
Thr Pro Leu Pro Pro Thr Ser Ala His Gly Asn Val Ala Glu Gly Glu 
1               5                   10                  15      


Thr Lys Pro Asp Pro Asp Val Thr Glu Arg Cys Ser Asp Gly Trp Ser 
            20                  25                  30          


Phe Asp Ala Thr Thr Leu Asp Asp Asn Gly Thr Met Leu Phe Phe Lys 
        35                  40                  45              


Gly Glu Phe Val Trp Lys Ser His Lys Trp Asp Arg Glu Leu Ile Ser 
    50                  55                  60                  


Glu Arg Trp Lys Asn Phe Pro Ser Pro Val Asp Ala Ala Phe Arg Gln 
65                  70                  75                  80  


Gly His Asn Ser Val Phe Leu Ile Lys Gly Asp Lys Val Trp Val Tyr 
                85                  90                  95      


Pro Pro Glu Lys Lys Glu Lys Gly Tyr Pro Lys Leu Leu Gln Asp Glu 
            100                 105                 110         


Phe Pro Gly Ile Pro Ser Pro Leu Asp Ala Ala Val Glu Cys His Arg 
        115                 120                 125             


Gly Glu Cys Gln Ala Glu Gly Val Leu Phe Phe Gln Gly Asp Arg Glu 
    130                 135                 140                 


Trp Phe Trp Asp Leu Ala Thr Gly Thr Met Lys Glu Arg Ser Trp Pro 
145                 150                 155                 160 


Ala Val Gly Asn Cys Ser Ser Ala Leu Arg Trp Leu Gly Arg Tyr Tyr 
                165                 170                 175     


Cys Phe Gln Gly Asn Gln Phe Leu Arg Phe Asp Pro Val Arg Gly Glu 
            180                 185                 190         


Val Pro Pro Arg Tyr Pro Arg Asp Val Arg Asp Tyr Phe Met Pro Cys 
        195                 200                 205             


Pro Gly Arg Gly His Gly His Arg Asn Gly Thr Gly His Gly Asn Ser 
    210                 215                 220                 


Thr His His Gly Pro Glu Tyr Met Arg 
225                 230             


<210> 10
<211> 210
<212> PRT
<213> Homo sapiens

<400> 10
Thr Glu Arg Cys Ser Asp Gly Trp Ser Phe Asp Ala Thr Thr Leu Asp 
1               5                   10                  15      


Asp Asn Gly Thr Met Leu Phe Phe Lys Gly Glu Phe Val Trp Lys Ser 
            20                  25                  30          


His Lys Trp Asp Arg Glu Leu Ile Ser Glu Arg Trp Lys Asn Phe Pro 
        35                  40                  45              


Ser Pro Val Asp Ala Ala Phe Arg Gln Gly His Asn Ser Val Phe Leu 
    50                  55                  60                  


Ile Lys Gly Asp Lys Val Trp Val Tyr Pro Pro Glu Lys Lys Glu Lys 
65                  70                  75                  80  


Gly Tyr Pro Lys Leu Leu Gln Asp Glu Phe Pro Gly Ile Pro Ser Pro 
                85                  90                  95      


Leu Asp Ala Ala Val Glu Cys His Arg Gly Glu Cys Gln Ala Glu Gly 
            100                 105                 110         


Val Leu Phe Phe Gln Gly Asp Arg Glu Trp Phe Trp Asp Leu Ala Thr 
        115                 120                 125             


Gly Thr Met Lys Glu Arg Ser Trp Pro Ala Val Gly Asn Cys Ser Ser 
    130                 135                 140                 


Ala Leu Arg Trp Leu Gly Arg Tyr Tyr Cys Phe Gln Gly Asn Gln Phe 
145                 150                 155                 160 


Leu Arg Phe Asp Pro Val Arg Gly Glu Val Pro Pro Arg Tyr Pro Arg 
                165                 170                 175     


Asp Val Arg Asp Tyr Phe Met Pro Cys Pro Gly Arg Gly His Gly His 
            180                 185                 190         


Arg Asn Gly Thr Gly His Gly Asn Ser Thr His His Gly Pro Glu Tyr 
        195                 200                 205             


Met Arg 
    210 


<210> 11
<211> 206
<212> PRT
<213> Homo sapiens

<400> 11
Ser Asp Gly Trp Ser Phe Asp Ala Thr Thr Leu Asp Asp Asn Gly Thr 
1               5                   10                  15      


Met Leu Phe Phe Lys Gly Glu Phe Val Trp Lys Ser His Lys Trp Asp 
            20                  25                  30          


Arg Glu Leu Ile Ser Glu Arg Trp Lys Asn Phe Pro Ser Pro Val Asp 
        35                  40                  45              


Ala Ala Phe Arg Gln Gly His Asn Ser Val Phe Leu Ile Lys Gly Asp 
    50                  55                  60                  


Lys Val Trp Val Tyr Pro Pro Glu Lys Lys Glu Lys Gly Tyr Pro Lys 
65                  70                  75                  80  


Leu Leu Gln Asp Glu Phe Pro Gly Ile Pro Ser Pro Leu Asp Ala Ala 
                85                  90                  95      


Val Glu Cys His Arg Gly Glu Cys Gln Ala Glu Gly Val Leu Phe Phe 
            100                 105                 110         


Gln Gly Asp Arg Glu Trp Phe Trp Asp Leu Ala Thr Gly Thr Met Lys 
        115                 120                 125             


Glu Arg Ser Trp Pro Ala Val Gly Asn Cys Ser Ser Ala Leu Arg Trp 
    130                 135                 140                 


Leu Gly Arg Tyr Tyr Cys Phe Gln Gly Asn Gln Phe Leu Arg Phe Asp 
145                 150                 155                 160 


Pro Val Arg Gly Glu Val Pro Pro Arg Tyr Pro Arg Asp Val Arg Asp 
                165                 170                 175     


Tyr Phe Met Pro Cys Pro Gly Arg Gly His Gly His Arg Asn Gly Thr 
            180                 185                 190         


Gly His Gly Asn Ser Thr His His Gly Pro Glu Tyr Met Arg 
        195                 200                 205     


<210> 12
<211> 220
<212> PRT
<213> Homo sapiens

<400> 12
Thr Pro Leu Pro Pro Thr Ser Ala His Gly Asn Val Ala Glu Gly Glu 
1               5                   10                  15      


Thr Lys Pro Asp Pro Asp Val Thr Glu Arg Cys Ser Asp Gly Trp Ser 
            20                  25                  30          


Phe Asp Ala Thr Thr Leu Asp Asp Asn Gly Thr Met Leu Phe Phe Lys 
        35                  40                  45              


Gly Glu Phe Val Trp Lys Ser His Lys Trp Asp Arg Glu Leu Ile Ser 
    50                  55                  60                  


Glu Arg Trp Lys Asn Phe Pro Ser Pro Val Asp Ala Ala Phe Arg Gln 
65                  70                  75                  80  


Gly His Asn Ser Val Phe Leu Ile Lys Gly Asp Lys Val Trp Val Tyr 
                85                  90                  95      


Pro Pro Glu Lys Lys Glu Lys Gly Tyr Pro Lys Leu Leu Gln Asp Glu 
            100                 105                 110         


Phe Pro Gly Ile Pro Ser Pro Leu Asp Ala Ala Val Glu Cys His Arg 
        115                 120                 125             


Gly Glu Cys Gln Ala Glu Gly Val Leu Phe Phe Gln Gly Asp Arg Glu 
    130                 135                 140                 


Trp Phe Trp Asp Leu Ala Thr Gly Thr Met Lys Glu Arg Ser Trp Pro 
145                 150                 155                 160 


Ala Val Gly Asn Cys Ser Ser Ala Leu Arg Trp Leu Gly Arg Tyr Tyr 
                165                 170                 175     


Cys Phe Gln Gly Asn Gln Phe Leu Arg Phe Asp Pro Val Arg Gly Glu 
            180                 185                 190         


Val Pro Pro Arg Tyr Pro Arg Asp Val Arg Asp Tyr Phe Met Pro Cys 
        195                 200                 205             


Pro Gly Arg Gly His Gly His Arg Asn Gly Thr Gly 
    210                 215                 220 


<210> 13
<211> 213
<212> PRT
<213> Homo sapiens

<400> 13
Thr Pro Leu Pro Pro Thr Ser Ala His Gly Asn Val Ala Glu Gly Glu 
1               5                   10                  15      


Thr Lys Pro Asp Pro Asp Val Thr Glu Arg Cys Ser Asp Gly Trp Ser 
            20                  25                  30          


Phe Asp Ala Thr Thr Leu Asp Asp Asn Gly Thr Met Leu Phe Phe Lys 
        35                  40                  45              


Gly Glu Phe Val Trp Lys Ser His Lys Trp Asp Arg Glu Leu Ile Ser 
    50                  55                  60                  


Glu Arg Trp Lys Asn Phe Pro Ser Pro Val Asp Ala Ala Phe Arg Gln 
65                  70                  75                  80  


Gly His Asn Ser Val Phe Leu Ile Lys Gly Asp Lys Val Trp Val Tyr 
                85                  90                  95      


Pro Pro Glu Lys Lys Glu Lys Gly Tyr Pro Lys Leu Leu Gln Asp Glu 
            100                 105                 110         


Phe Pro Gly Ile Pro Ser Pro Leu Asp Ala Ala Val Glu Cys His Arg 
        115                 120                 125             


Gly Glu Cys Gln Ala Glu Gly Val Leu Phe Phe Gln Gly Asp Arg Glu 
    130                 135                 140                 


Trp Phe Trp Asp Leu Ala Thr Gly Thr Met Lys Glu Arg Ser Trp Pro 
145                 150                 155                 160 


Ala Val Gly Asn Cys Ser Ser Ala Leu Arg Trp Leu Gly Arg Tyr Tyr 
                165                 170                 175     


Cys Phe Gln Gly Asn Gln Phe Leu Arg Phe Asp Pro Val Arg Gly Glu 
            180                 185                 190         


Val Pro Pro Arg Tyr Pro Arg Asp Val Arg Asp Tyr Phe Met Pro Cys 
        195                 200                 205             


Pro Gly Arg Gly His 
    210             


<210> 14
<211> 212
<212> PRT
<213> Homo sapiens

<400> 14
Thr Pro Leu Pro Pro Thr Ser Ala His Gly Asn Val Ala Glu Gly Glu 
1               5                   10                  15      


Thr Lys Pro Asp Pro Asp Val Thr Glu Arg Cys Ser Asp Gly Trp Ser 
            20                  25                  30          


Phe Asp Ala Thr Thr Leu Asp Asp Asn Gly Thr Met Leu Phe Phe Lys 
        35                  40                  45              


Gly Glu Phe Val Trp Lys Ser His Lys Trp Asp Arg Glu Leu Ile Ser 
    50                  55                  60                  


Glu Arg Trp Lys Asn Phe Pro Ser Pro Val Asp Ala Ala Phe Arg Gln 
65                  70                  75                  80  


Gly His Asn Ser Val Phe Leu Ile Lys Gly Asp Lys Val Trp Val Tyr 
                85                  90                  95      


Pro Pro Glu Lys Lys Glu Lys Gly Tyr Pro Lys Leu Leu Gln Asp Glu 
            100                 105                 110         


Phe Pro Gly Ile Pro Ser Pro Leu Asp Ala Ala Val Glu Cys His Arg 
        115                 120                 125             


Gly Glu Cys Gln Ala Glu Gly Val Leu Phe Phe Gln Gly Asp Arg Glu 
    130                 135                 140                 


Trp Phe Trp Asp Leu Ala Thr Gly Thr Met Lys Glu Arg Ser Trp Pro 
145                 150                 155                 160 


Ala Val Gly Asn Cys Ser Ser Ala Leu Arg Trp Leu Gly Arg Tyr Tyr 
                165                 170                 175     


Cys Phe Gln Gly Asn Gln Phe Leu Arg Phe Asp Pro Val Arg Gly Glu 
            180                 185                 190         


Val Pro Pro Arg Tyr Pro Arg Asp Val Arg Asp Tyr Phe Met Pro Cys 
        195                 200                 205             


Pro Gly Arg Gly 
    210         


<210> 15
<211> 207
<212> PRT
<213> Homo sapiens

<400> 15
Thr Pro Leu Pro Pro Thr Ser Ala His Gly Asn Val Ala Glu Gly Glu 
1               5                   10                  15      


Thr Lys Pro Asp Pro Asp Val Thr Glu Arg Cys Ser Asp Gly Trp Ser 
            20                  25                  30          


Phe Asp Ala Thr Thr Leu Asp Asp Asn Gly Thr Met Leu Phe Phe Lys 
        35                  40                  45              


Gly Glu Phe Val Trp Lys Ser His Lys Trp Asp Arg Glu Leu Ile Ser 
    50                  55                  60                  


Glu Arg Trp Lys Asn Phe Pro Ser Pro Val Asp Ala Ala Phe Arg Gln 
65                  70                  75                  80  


Gly His Asn Ser Val Phe Leu Ile Lys Gly Asp Lys Val Trp Val Tyr 
                85                  90                  95      


Pro Pro Glu Lys Lys Glu Lys Gly Tyr Pro Lys Leu Leu Gln Asp Glu 
            100                 105                 110         


Phe Pro Gly Ile Pro Ser Pro Leu Asp Ala Ala Val Glu Cys His Arg 
        115                 120                 125             


Gly Glu Cys Gln Ala Glu Gly Val Leu Phe Phe Gln Gly Asp Arg Glu 
    130                 135                 140                 


Trp Phe Trp Asp Leu Ala Thr Gly Thr Met Lys Glu Arg Ser Trp Pro 
145                 150                 155                 160 


Ala Val Gly Asn Cys Ser Ser Ala Leu Arg Trp Leu Gly Arg Tyr Tyr 
                165                 170                 175     


Cys Phe Gln Gly Asn Gln Phe Leu Arg Phe Asp Pro Val Arg Gly Glu 
            180                 185                 190         


Val Pro Pro Arg Tyr Pro Arg Asp Val Arg Asp Tyr Phe Met Pro 
        195                 200                 205         


<210> 16
<211> 437
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      polypeptide

<400> 16
Thr Pro Leu Pro Pro Thr Ser Ala His Gly Asn Val Ala Glu Gly Glu 
1               5                   10                  15      


Thr Lys Pro Asp Pro Asp Val Thr Glu Arg Cys Ser Asp Gly Trp Ser 
            20                  25                  30          


Phe Asp Ala Thr Thr Leu Asp Asp Asn Gly Thr Met Leu Phe Phe Lys 
        35                  40                  45              


Gly Glu Phe Val Trp Lys Ser His Lys Trp Asp Arg Glu Leu Ile Ser 
    50                  55                  60                  


Glu Arg Trp Lys Asn Phe Pro Ser Pro Val Asp Ala Ala Phe Arg Gln 
65                  70                  75                  80  


Gly His Asn Ser Val Phe Leu Ile Lys Gly Asp Lys Val Trp Val Tyr 
                85                  90                  95      


Pro Pro Glu Lys Lys Glu Lys Gly Tyr Pro Lys Leu Leu Gln Asp Glu 
            100                 105                 110         


Phe Pro Gly Ile Pro Ser Pro Leu Asp Ala Ala Val Glu Cys His Arg 
        115                 120                 125             


Gly Glu Cys Gln Ala Glu Gly Val Leu Phe Phe Gln Gly Asp Arg Glu 
    130                 135                 140                 


Trp Phe Trp Asp Leu Ala Thr Gly Thr Met Lys Glu Arg Ser Trp Pro 
145                 150                 155                 160 


Ala Val Gly Asn Cys Ser Ser Ala Leu Arg Trp Leu Gly Arg Tyr Tyr 
                165                 170                 175     


Cys Phe Gln Gly Asn Gln Phe Leu Arg Phe Asp Pro Val Arg Gly Glu 
            180                 185                 190         


Val Pro Pro Arg Tyr Pro Arg Asp Val Arg Asp Tyr Phe Met Pro Cys 
        195                 200                 205             


Pro Gly Arg Gly His Gly His Arg Asn Gly Thr Gly Ser Gly Ser His 
    210                 215                 220                 


His Gly Pro Glu Tyr Met Arg Cys Ser Pro His Leu Val Leu Ser Ala 
225                 230                 235                 240 


Leu Thr Ser Asp Asn His Gly Ala Thr Tyr Ala Phe Ser Gly Thr His 
                245                 250                 255     


Tyr Trp Arg Leu Asp Thr Ser Arg Asp Gly Trp His Ser Trp Pro Ile 
            260                 265                 270         


Ala His Gln Trp Pro Gln Gly Pro Ser Ala Val Asp Ala Ala Phe Ser 
        275                 280                 285             


Trp Glu Glu Lys Leu Tyr Leu Val Gln Gly Thr Gln Val Tyr Val Phe 
    290                 295                 300                 


Leu Thr Lys Gly Gly Tyr Thr Leu Val Ser Gly Tyr Pro Lys Arg Leu 
305                 310                 315                 320 


Glu Lys Glu Val Gly Thr Pro His Gly Ile Ile Leu Asp Ser Val Asp 
                325                 330                 335     


Ala Ala Phe Ile Cys Pro Gly Ser Ser Arg Leu His Ile Met Ala Gly 
            340                 345                 350         


Arg Arg Leu Trp Trp Leu Asp Leu Lys Ser Gly Ala Gln Ala Thr Trp 
        355                 360                 365             


Thr Glu Leu Pro Trp Pro His Glu Lys Val Asp Gly Ala Leu Cys Met 
    370                 375                 380                 


Glu Lys Ser Leu Gly Pro Asn Ser Cys Ser Ala Asn Gly Pro Gly Leu 
385                 390                 395                 400 


Tyr Leu Ile His Gly Pro Asn Leu Tyr Cys Tyr Ser Asp Val Glu Lys 
                405                 410                 415     


Leu Asn Ala Ala Lys Ala Leu Pro Gln Pro Gln Asn Val Thr Ser Leu 
            420                 425                 430         


Leu Gly Cys Thr His 
        435         


<210> 17
<211> 235
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      polypeptide

<400> 17
Ala Lys Thr Glu Pro Lys Ser Ser Asp Lys Thr His Thr Cys Pro Pro 
1               5                   10                  15      


Cys Pro Ala Pro Glu Leu Leu Gly Gly Pro Ser Val Phe Leu Phe Pro 
            20                  25                  30          


Pro Lys Pro Lys Asp Thr Leu Met Ile Ser Arg Thr Pro Glu Val Thr 
        35                  40                  45              


Cys Val Val Val Asp Val Ser His Glu Asp Pro Glu Val Lys Phe Asn 
    50                  55                  60                  


Trp Tyr Val Asp Gly Val Glu Val His Asn Ala Lys Thr Lys Pro Arg 
65                  70                  75                  80  


Glu Glu Gln Tyr Asp Ser Thr Tyr Arg Val Val Ser Val Leu Thr Val 
                85                  90                  95      


Leu His Gln Asp Trp Leu Asn Gly Lys Glu Tyr Lys Cys Lys Val Ser 
            100                 105                 110         


Asn Lys Ala Leu Pro Ala Pro Ile Glu Lys Thr Ile Ser Lys Ala Lys 
        115                 120                 125             


Gly Gln Pro Arg Glu Pro Gln Val Tyr Thr Leu Pro Pro Ser Arg Asp 
    130                 135                 140                 


Glu Leu Thr Lys Asn Gln Val Ser Leu Thr Cys Leu Val Lys Gly Phe 
145                 150                 155                 160 


Tyr Pro Ser Asp Ile Ala Val Glu Trp Glu Ser Asn Gly Gln Pro Glu 
                165                 170                 175     


Asn Asn Tyr Lys Thr Thr Pro Pro Val Leu Asp Ser Asp Gly Ser Phe 
            180                 185                 190         


Phe Leu Tyr Ser Lys Leu Thr Val Asp Lys Ser Arg Trp Gln Gln Gly 
        195                 200                 205             


Asn Val Phe Ser Cys Ser Val Met His Glu Ala Leu His Asn His Tyr 
    210                 215                 220                 


Thr Gln Lys Ser Leu Ser Leu Ser Pro Gly Ala 
225                 230                 235 


<210> 18
<211> 4
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      peptide

<400> 18
Gly Ser Gly Ser 
1               

