                         SEQUENCE LISTING

<110>  Yale University
       Galan, Jorge E.
       Song, Jeongmin E.
 
<120>  COMPOSITIONS AND METHODS FOR DIAGNOSING, PREVENTING, AND TREATING SALMONELLA 
       TYPHI AND SALMONELLA PARATYPHI INFECTION

<130>  047162-5150-00-WO.602944

<150>  US 61/825,375
<151>  2013-05-20

<160>  21    

<170>  PatentIn version 3.5

<210>  1
<211>  60
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  chemically synthesized

<400>  1
gatccccgga caaatgggat gaactattca agagatagtt catcccattt gtcctttttc       60


<210>  2
<211>  60
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  chemically synthesized

<400>  2
tcgagaaaaa ggacaaatgg gatgaactat ctcttgaata gttcatccca tttgtccggg       60


<210>  3
<211>  19
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  chemically synthesized

<400>  3
accggggact acaaccctg                                                    19


<210>  4
<211>  22
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  chemically synthesized

<400>  4
tgtggtgtta ggtttagctg tg                                                22


<210>  5
<211>  22
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  chemically synthesized

<400>  5
gattactgct ctggctccta gc                                                22


<210>  6
<211>  22
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  chemically synthesized

<400>  6
gactcatcgt actcctgctt gc                                                22


<210>  7
<211>  269
<212>  PRT
<213>  Salmonella typhi

<400>  7

Met Lys Lys Pro Val Phe Phe Leu Leu Thr Met Ile Ile Cys Ser Tyr 
1               5                   10                  15      


Ile Ser Phe Ala Cys Ala Asn Ile Ser Asp Tyr Lys Val Met Thr Trp 
            20                  25                  30          


Asn Leu Gln Gly Ser Ser Ala Ser Thr Glu Ser Lys Trp Asn Val Asn 
        35                  40                  45              


Val Arg Gln Leu Leu Ser Gly Thr Ala Gly Val Asp Ile Leu Met Val 
    50                  55                  60                  


Gln Glu Ala Gly Ala Val Pro Thr Ser Ala Val Pro Thr Gly Arg His 
65                  70                  75                  80  


Ile Gln Pro Phe Gly Val Gly Ile Pro Ile Asp Glu Tyr Thr Trp Asn 
                85                  90                  95      


Leu Gly Thr Thr Ser Arg Gln Asp Ile Arg Tyr Ile Tyr His Ser Ala 
            100                 105                 110         


Ile Asp Val Gly Ala Arg Arg Val Asn Leu Ala Ile Val Ser Arg Gln 
        115                 120                 125             


Arg Ala Asp Asn Val Tyr Val Leu Arg Pro Thr Thr Val Ala Ser Arg 
    130                 135                 140                 


Pro Val Ile Gly Ile Gly Leu Gly Asn Asp Val Phe Leu Thr Ala His 
145                 150                 155                 160 


Ala Leu Ala Ser Gly Gly Pro Asp Ala Ala Ala Ile Val Arg Val Thr 
                165                 170                 175     


Ile Asn Phe Phe Arg Gln Pro Gln Met Arg His Leu Ser Trp Phe Leu 
            180                 185                 190         


Ala Gly Asp Phe Asn Arg Ser Pro Asp Arg Leu Glu Asn Asp Leu Met 
        195                 200                 205             


Thr Glu His Leu Glu Arg Val Val Ala Val Leu Ala Pro Thr Glu Pro 
    210                 215                 220                 


Thr Gln Ile Gly Gly Gly Ile Leu Asp Tyr Gly Val Ile Val Asp Arg 
225                 230                 235                 240 


Ala Pro Tyr Ser Gln Arg Val Glu Ala Leu Arg Asn Pro Gln Leu Ala 
                245                 250                 255     


Ser Asp His Tyr Pro Val Ala Phe Leu Ala Arg Ser Cys 
            260                 265                 


<210>  8
<211>  242
<212>  PRT
<213>  Salmonella typhi

<400>  8

Met Lys Lys Leu Ile Phe Leu Thr Leu Ser Ile Val Ser Phe Asn Asn 
1               5                   10                  15      


Tyr Ala Val Asp Phe Val Tyr Arg Val Asp Ser Thr Pro Pro Asp Val 
            20                  25                  30          


Ile Phe Arg Asp Gly Phe Ser Leu Leu Gly Tyr Asn Arg Asn Phe Gln 
        35                  40                  45              


Gln Phe Ile Ser Gly Arg Ser Cys Ser Gly Gly Ser Ser Asp Ser Arg 
    50                  55                  60                  


Tyr Ile Ala Thr Thr Ser Ser Val Asn Gln Thr Tyr Ala Ile Ala Arg 
65                  70                  75                  80  


Ala Tyr Tyr Ser Arg Ser Thr Phe Lys Gly Asn Leu Tyr Arg Tyr Gln 
                85                  90                  95      


Ile Arg Ala Asp Asn Asn Phe Tyr Ser Leu Leu Pro Ser Ile Thr Tyr 
            100                 105                 110         


Leu Glu Thr Gln Gly Gly His Phe Asn Ala Tyr Glu Lys Thr Met Met 
        115                 120                 125             


Arg Leu Gln Arg Glu Tyr Val Ser Thr Leu Ser Ile Leu Pro Glu Asn 
    130                 135                 140                 


Ile Gln Lys Ala Val Ala Leu Val Tyr Asp Ser Ala Thr Gly Leu Val 
145                 150                 155                 160 


Lys Asp Gly Val Ser Thr Met Asn Ala Ser Tyr Leu Gly Leu Ser Thr 
                165                 170                 175     


Thr Ser Asn Pro Gly Val Ile Pro Phe Leu Pro Glu Pro Gln Thr Tyr 
            180                 185                 190         


Thr Gln Gln Arg Ile Asp Ala Phe Gly Pro Leu Ile Ser Ser Cys Phe 
        195                 200                 205             


Ser Ile Gly Ser Val Cys His Ser His Arg Gly Gln Arg Ala Asp Val 
    210                 215                 220                 


Tyr Asn Met Ser Phe Tyr Asp Ala Arg Pro Val Ile Glu Leu Ile Leu 
225                 230                 235                 240 


Ser Lys 
        


<210>  9
<211>  137
<212>  PRT
<213>  Salmonella typhi

<400>  9

Met Tyr Met Ser Lys Tyr Val Pro Val Tyr Thr Leu Leu Ile Leu Ile 
1               5                   10                  15      


Tyr Ser Phe Asn Ala Ser Ala Glu Trp Thr Gly Asp Asn Thr Asn Ala 
            20                  25                  30          


Tyr Tyr Ser Asp Glu Val Ile Ser Glu Leu His Val Gly Gln Ile Asp 
        35                  40                  45              


Thr Ser Pro Tyr Phe Cys Ile Lys Thr Val Lys Ala Asn Gly Ser Gly 
    50                  55                  60                  


Thr Pro Val Val Ala Cys Ala Val Ser Lys Gln Ser Ile Trp Ala Pro 
65                  70                  75                  80  


Ser Phe Lys Glu Leu Leu Asp Gln Ala Arg Tyr Phe Tyr Ser Thr Gly 
                85                  90                  95      


Gln Ser Val Arg Ile His Val Gln Lys Asn Ile Trp Thr Tyr Pro Leu 
            100                 105                 110         


Phe Val Asn Thr Phe Ser Ala Asn Ala Leu Val Gly Leu Ser Ser Cys 
        115                 120                 125             


Ser Ala Thr Gln Cys Phe Gly Pro Lys 
    130                 135         


<210>  10
<211>  558
<212>  PRT
<213>  Homo sapiens

<400>  10

Met Arg Cys Ala Leu Ala Leu Ser Ala Leu Leu Leu Leu Leu Ser Thr 
1               5                   10                  15      


Pro Pro Leu Leu Pro Ser Ser Pro Ser Pro Ser Pro Ser Pro Ser Gln 
            20                  25                  30          


Asn Ala Thr Gln Thr Thr Thr Asp Ser Ser Asn Lys Thr Ala Pro Thr 
        35                  40                  45              


Pro Ala Ser Ser Val Thr Ile Met Ala Thr Asp Thr Ala Gln Gln Ser 
    50                  55                  60                  


Thr Val Pro Thr Ser Lys Ala Asn Glu Ile Leu Ala Ser Val Lys Ala 
65                  70                  75                  80  


Thr Thr Leu Gly Val Ser Ser Asp Ser Pro Gly Thr Thr Thr Leu Ala 
                85                  90                  95      


Gln Gln Val Ser Gly Pro Val Asn Thr Thr Val Ala Arg Gly Gly Gly 
            100                 105                 110         


Ser Gly Asn Pro Thr Thr Thr Ile Glu Ser Pro Lys Ser Thr Lys Ser 
        115                 120                 125             


Ala Asp Thr Thr Thr Val Ala Thr Ser Thr Ala Thr Ala Lys Pro Asn 
    130                 135                 140                 


Thr Thr Ser Ser Gln Asn Gly Ala Glu Asp Thr Thr Asn Ser Gly Gly 
145                 150                 155                 160 


Lys Ser Ser His Ser Val Thr Thr Asp Leu Thr Ser Thr Lys Ala Glu 
                165                 170                 175     


His Leu Thr Thr Pro His Pro Thr Ser Pro Leu Ser Pro Arg Gln Pro 
            180                 185                 190         


Thr Ser Thr His Pro Val Ala Thr Pro Thr Ser Ser Gly His Asp His 
        195                 200                 205             


Leu Met Lys Ile Ser Ser Ser Ser Ser Thr Val Ala Ile Pro Gly Tyr 
    210                 215                 220                 


Thr Phe Thr Ser Pro Gly Met Thr Thr Thr Leu Leu Glu Thr Val Phe 
225                 230                 235                 240 


His His Val Ser Gln Ala Gly Leu Glu Leu Leu Thr Ser Gly Asp Leu 
                245                 250                 255     


Pro Thr Leu Ala Ser Gln Ser Ala Gly Ile Thr Ala Ser Ser Val Ile 
            260                 265                 270         


Ser Gln Arg Thr Gln Gln Thr Ser Ser Gln Met Pro Ala Ser Ser Thr 
        275                 280                 285             


Ala Pro Ser Ser Gln Glu Thr Val Gln Pro Thr Ser Pro Ala Thr Ala 
    290                 295                 300                 


Leu Arg Thr Pro Thr Leu Pro Glu Thr Met Ser Ser Ser Pro Thr Ala 
305                 310                 315                 320 


Ala Ser Thr Thr His Arg Tyr Pro Lys Thr Pro Ser Pro Thr Val Ala 
                325                 330                 335     


His Glu Ser Asn Trp Ala Lys Cys Glu Asp Leu Glu Thr Gln Thr Gln 
            340                 345                 350         


Ser Glu Lys Gln Leu Val Leu Asn Leu Thr Gly Asn Thr Leu Cys Ala 
        355                 360                 365             


Gly Gly Ala Ser Asp Glu Lys Leu Ile Ser Leu Ile Cys Arg Ala Val 
    370                 375                 380                 


Lys Ala Thr Phe Asn Pro Ala Gln Asp Lys Cys Gly Ile Arg Leu Ala 
385                 390                 395                 400 


Ser Val Pro Gly Ser Gln Thr Val Val Val Lys Glu Ile Thr Ile His 
                405                 410                 415     


Thr Lys Leu Pro Ala Lys Asp Val Tyr Glu Arg Leu Lys Asp Lys Trp 
            420                 425                 430         


Asp Glu Leu Lys Glu Ala Gly Val Ser Asp Met Lys Leu Gly Asp Gln 
        435                 440                 445             


Gly Pro Pro Glu Glu Ala Glu Asp Arg Phe Ser Met Pro Leu Ile Ile 
    450                 455                 460                 


Thr Ile Val Cys Met Ala Ser Phe Leu Leu Leu Val Ala Ala Leu Tyr 
465                 470                 475                 480 


Gly Cys Cys His Gln Arg Leu Ser Gln Arg Lys Asp Gln Gln Arg Leu 
                485                 490                 495     


Thr Glu Glu Leu Gln Thr Val Glu Asn Gly Tyr His Asp Asn Pro Thr 
            500                 505                 510         


Leu Glu Val Met Glu Thr Ser Ser Glu Met Gln Glu Lys Lys Val Val 
        515                 520                 525             


Ser Leu Asn Gly Glu Leu Gly Asp Ser Trp Ile Val Pro Leu Asp Asn 
    530                 535                 540                 


Leu Thr Lys Asp Asp Leu Asp Glu Glu Glu Asp Thr His Leu 
545                 550                 555             


<210>  11
<211>  42
<212>  PRT
<213>  Aggregatibacter actinomycetemcomitans

<400>  11

Leu Gly Asp Ala His Leu Pro Arg Arg Glu Gln Val Arg Glu Arg Ile 
1               5                   10                  15      


Gly Ala Ser Leu Met Leu Asn Gln Leu Arg Ser Gln Ile Thr Ser Asp 
            20                  25                  30          


His Phe Pro Val Ser Phe Val His Asp Arg 
        35                  40          


<210>  12
<211>  42
<212>  PRT
<213>  Haemophilus ducreyi

<400>  12

Leu His Asp Ala His Leu Pro Arg Arg Glu Gln Ala Arg Glu Arg Ile 
1               5                   10                  15      


Gly Ala Ser Leu Met Leu Asn Gln Leu Arg Ser Gln Ile Thr Ser Asp 
            20                  25                  30          


His Phe Pro Val Ser Phe Val Arg Asp Arg 
        35                  40          


<210>  13
<211>  33
<212>  PRT
<213>  Salmonella typhi

<400>  13

Ile Val Asp Arg Ala Pro Tyr Ser Gln Arg Val Glu Ala Leu Arg Asn 
1               5                   10                  15      


Pro Gln Leu Ala Ser Asp His Tyr Pro Val Ala Phe Leu Ala Arg Ser 
            20                  25                  30          


Cys 
    


<210>  14
<211>  40
<212>  PRT
<213>  Campylobacter jejuni

<400>  14

Thr Gly Asn Ser Asn Arg Gln Gln Thr Tyr Thr Pro Pro Leu Leu Ala 
1               5                   10                  15      


Ala Ile Leu Met Leu Ala Ser Leu Arg Ser His Ile Val Ser Asp His 
            20                  25                  30          


Phe Pro Val Asn Phe Arg Lys Phe 
        35                  40  


<210>  15
<211>  41
<212>  PRT
<213>  Helicobacter hepaticus

<400>  15

Val Gly Arg Ser Ser Pro Ser Arg Ser Thr Ile Val Leu Pro Gln Ile 
1               5                   10                  15      


Ala Ala Ile Leu Met Ala Ala Asn Ile Arg Ala His Leu Ser Ser Asp 
            20                  25                  30          


His Ser Pro Val His Phe Gly Arg Phe 
        35                  40      


<210>  16
<211>  37
<212>  PRT
<213>  Providencia alcalifaciens

<400>  16

Ala Gly Asn Ala Val Ala Phe Arg Pro Leu Pro Leu Gln Ala Gly Ile 
1               5                   10                  15      


Val Tyr Gly Ala Arg Arg Thr Gln Ile Ser Ser Asp His Tyr Pro Val 
            20                  25                  30          


Gly Val Phe Arg Arg 
        35          


<210>  17
<211>  37
<212>  PRT
<213>  Shigella boydii

<400>  17

Ala Gly Asn Ala Val Ala Phe Arg Pro Phe Pro Leu Gln Ala Gly Ile 
1               5                   10                  15      


Val Tyr Gly Ala Arg Arg Thr Gln Ile Ser Ser Asp His Tyr Pro Val 
            20                  25                  30          


Gly Val Ser Arg Arg 
        35          


<210>  18
<211>  42
<212>  PRT
<213>  Escherichia coli

<400>  18

Val Gly Asn Ser Val Ser Phe Val Leu Pro Leu Leu Arg Ala Ser Leu 
1               5                   10                  15      


Leu Phe Gly Leu Leu Arg Gly Gln Ile Ala Ser Asp His Phe Pro Val 
            20                  25                  30          


Gly Phe Ile Pro Gly Arg Gly Ala Arg Arg 
        35                  40          


<210>  19
<211>  60
<212>  PRT
<213>  Salmonella typhi

<400>  19

Gly Val Ile Pro Phe Leu Pro Glu Pro Gln Thr Tyr Thr Gln Gln Arg 
1               5                   10                  15      


Ile Asp Ala Phe Gly Pro Leu Ile Ser Ser Cys Phe Ser Ile Gly Ser 
            20                  25                  30          


Val Cys His Ser His Arg Gly Gln Arg Ala Asp Val Tyr Asn Met Ser 
        35                  40                  45              


Phe Tyr Asp Ala Arg Pro Val Ile Glu Leu Ile Leu 
    50                  55                  60  


<210>  20
<211>  60
<212>  PRT
<213>  Salmonella typhimurium

<400>  20

Gly Val Ile Pro Asn Leu Pro Val Pro Gln Val Ser Thr Arg Glu Arg 
1               5                   10                  15      


Ile Ser Ala Phe Gly Thr Leu Ile Ser Ala Cys Phe Ser Met Arg Gly 
            20                  25                  30          


Val Arg Arg Asp Asp Ala Arg Ser Asn Tyr Asn Tyr Tyr Glu Met Glu 
        35                  40                  45              


Phe Tyr Asp Ala Arg Gly Val Leu Thr Glu Leu Leu 
    50                  55                  60  


<210>  21
<211>  1304
<212>  PRT
<213>  Homo sapiens

<400>  21

Met Tyr Leu Trp Leu Lys Leu Leu Ala Phe Gly Phe Ala Phe Leu Asp 
1               5                   10                  15      


Thr Glu Val Phe Val Thr Gly Gln Ser Pro Thr Pro Ser Pro Thr Gly 
            20                  25                  30          


Leu Thr Thr Ala Lys Met Pro Ser Val Pro Leu Ser Ser Asp Pro Leu 
        35                  40                  45              


Pro Thr His Thr Thr Ala Phe Ser Pro Ala Ser Thr Phe Glu Arg Glu 
    50                  55                  60                  


Asn Asp Phe Ser Glu Thr Thr Thr Ser Leu Ser Pro Asp Asn Thr Ser 
65                  70                  75                  80  


Thr Gln Val Ser Pro Asp Ser Leu Asp Asn Ala Ser Ala Phe Asn Thr 
                85                  90                  95      


Thr Gly Val Ser Ser Val Gln Thr Pro His Leu Pro Thr His Ala Asp 
            100                 105                 110         


Ser Gln Thr Pro Ser Ala Gly Thr Asp Thr Gln Thr Phe Ser Gly Ser 
        115                 120                 125             


Ala Ala Asn Ala Lys Leu Asn Pro Thr Pro Gly Ser Asn Ala Ile Ser 
    130                 135                 140                 


Asp Val Pro Gly Glu Arg Ser Thr Ala Ser Thr Phe Pro Thr Asp Pro 
145                 150                 155                 160 


Val Ser Pro Leu Thr Thr Thr Leu Ser Leu Ala His His Ser Ser Ala 
                165                 170                 175     


Ala Leu Pro Ala Arg Thr Ser Asn Thr Thr Ile Thr Ala Asn Thr Ser 
            180                 185                 190         


Asp Ala Tyr Leu Asn Ala Ser Glu Thr Thr Thr Leu Ser Pro Ser Gly 
        195                 200                 205             


Ser Ala Val Ile Ser Thr Thr Thr Ile Ala Thr Thr Pro Ser Lys Pro 
    210                 215                 220                 


Thr Cys Asp Glu Lys Tyr Ala Asn Ile Thr Val Asp Tyr Leu Tyr Asn 
225                 230                 235                 240 


Lys Glu Thr Lys Leu Phe Thr Ala Lys Leu Asn Val Asn Glu Asn Val 
                245                 250                 255     


Glu Cys Gly Asn Asn Thr Cys Thr Asn Asn Glu Val His Asn Leu Thr 
            260                 265                 270         


Glu Cys Lys Asn Ala Ser Val Ser Ile Ser His Asn Ser Cys Thr Ala 
        275                 280                 285             


Pro Asp Lys Thr Leu Ile Leu Asp Val Pro Pro Gly Val Glu Lys Phe 
    290                 295                 300                 


Gln Leu His Asp Cys Thr Gln Val Glu Lys Ala Asp Thr Thr Ile Cys 
305                 310                 315                 320 


Leu Lys Trp Lys Asn Ile Glu Thr Phe Thr Cys Asp Thr Gln Asn Ile 
                325                 330                 335     


Thr Tyr Arg Phe Gln Cys Gly Asn Met Ile Phe Asp Asn Lys Glu Ile 
            340                 345                 350         


Lys Leu Glu Asn Leu Glu Pro Glu His Glu Tyr Lys Cys Asp Ser Glu 
        355                 360                 365             


Ile Leu Tyr Asn Asn His Lys Phe Thr Asn Ala Ser Lys Ile Ile Lys 
    370                 375                 380                 


Thr Asp Phe Gly Ser Pro Gly Glu Pro Gln Ile Ile Phe Cys Arg Ser 
385                 390                 395                 400 


Glu Ala Ala His Gln Gly Val Ile Thr Trp Asn Pro Pro Gln Arg Ser 
                405                 410                 415     


Phe His Asn Phe Thr Leu Cys Tyr Ile Lys Glu Thr Glu Lys Asp Cys 
            420                 425                 430         


Leu Asn Leu Asp Lys Asn Leu Ile Lys Tyr Asp Leu Gln Asn Leu Lys 
        435                 440                 445             


Pro Tyr Thr Lys Tyr Val Leu Ser Leu His Ala Tyr Ile Ile Ala Lys 
    450                 455                 460                 


Val Gln Arg Asn Gly Ser Ala Ala Met Cys His Phe Thr Thr Lys Ser 
465                 470                 475                 480 


Ala Pro Pro Ser Gln Val Trp Asn Met Thr Val Ser Met Thr Ser Asp 
                485                 490                 495     


Asn Ser Met His Val Lys Cys Arg Pro Pro Arg Asp Arg Asn Gly Pro 
            500                 505                 510         


His Glu Arg Tyr His Leu Glu Val Glu Ala Gly Asn Thr Leu Val Arg 
        515                 520                 525             


Asn Glu Ser His Lys Asn Cys Asp Phe Arg Val Lys Asp Leu Gln Tyr 
    530                 535                 540                 


Ser Thr Asp Tyr Thr Phe Lys Ala Tyr Phe His Asn Gly Asp Tyr Pro 
545                 550                 555                 560 


Gly Glu Pro Phe Ile Leu His His Ser Thr Ser Tyr Asn Ser Lys Ala 
                565                 570                 575     


Leu Ile Ala Phe Leu Ala Phe Leu Ile Ile Val Thr Ser Ile Ala Leu 
            580                 585                 590         


Leu Val Val Leu Tyr Lys Ile Tyr Asp Leu His Lys Lys Arg Ser Cys 
        595                 600                 605             


Asn Leu Asp Glu Gln Gln Glu Leu Val Glu Arg Asp Asp Glu Lys Gln 
    610                 615                 620                 


Leu Met Asn Val Glu Pro Ile His Ala Asp Ile Leu Leu Glu Thr Tyr 
625                 630                 635                 640 


Lys Arg Lys Ile Ala Asp Glu Gly Arg Leu Phe Leu Ala Glu Phe Gln 
                645                 650                 655     


Ser Ile Pro Arg Val Phe Ser Lys Phe Pro Ile Lys Glu Ala Arg Lys 
            660                 665                 670         


Pro Phe Asn Gln Asn Lys Asn Arg Tyr Val Asp Ile Leu Pro Tyr Asp 
        675                 680                 685             


Tyr Asn Arg Val Glu Leu Ser Glu Ile Asn Gly Asp Ala Gly Ser Asn 
    690                 695                 700                 


Tyr Ile Asn Ala Ser Tyr Ile Asp Gly Phe Lys Glu Pro Arg Lys Tyr 
705                 710                 715                 720 


Ile Ala Ala Gln Gly Pro Arg Asp Glu Thr Val Asp Asp Phe Trp Arg 
                725                 730                 735     


Met Ile Trp Glu Gln Lys Ala Thr Val Ile Val Met Val Thr Arg Cys 
            740                 745                 750         


Glu Glu Gly Asn Arg Asn Lys Cys Ala Glu Tyr Trp Pro Ser Met Glu 
        755                 760                 765             


Glu Gly Thr Arg Ala Phe Gly Asp Val Val Val Lys Ile Asn Gln His 
    770                 775                 780                 


Lys Arg Cys Pro Asp Tyr Ile Ile Gln Lys Leu Asn Ile Val Asn Lys 
785                 790                 795                 800 


Lys Glu Lys Ala Thr Gly Arg Glu Val Thr His Ile Gln Phe Thr Ser 
                805                 810                 815     


Trp Pro Asp His Gly Val Pro Glu Asp Pro His Leu Leu Leu Lys Leu 
            820                 825                 830         


Arg Arg Arg Val Asn Ala Phe Ser Asn Phe Phe Ser Gly Pro Ile Val 
        835                 840                 845             


Val His Cys Ser Ala Gly Val Gly Arg Thr Gly Thr Tyr Ile Gly Ile 
    850                 855                 860                 


Asp Ala Met Leu Glu Gly Leu Glu Ala Glu Asn Lys Val Asp Val Tyr 
865                 870                 875                 880 


Gly Tyr Val Val Lys Leu Arg Arg Gln Arg Cys Leu Met Val Gln Val 
                885                 890                 895     


Glu Ala Gln Tyr Ile Leu Ile His Gln Ala Leu Val Glu Tyr Asn Gln 
            900                 905                 910         


Phe Gly Glu Thr Glu Val Asn Leu Ser Glu Leu His Pro Tyr Leu His 
        915                 920                 925             


Asn Met Lys Lys Arg Asp Pro Pro Ser Glu Pro Ser Pro Leu Glu Ala 
    930                 935                 940                 


Glu Phe Gln Arg Leu Pro Ser Tyr Arg Ser Trp Arg Thr Gln His Ile 
945                 950                 955                 960 


Gly Asn Gln Glu Glu Asn Lys Ser Lys Asn Arg Asn Ser Asn Val Ile 
                965                 970                 975     


Pro Tyr Asp Tyr Asn Arg Val Pro Leu Lys His Glu Leu Glu Met Ser 
            980                 985                 990         


Lys Glu Ser Glu His Asp Ser Asp  Glu Ser Ser Asp Asp  Asp Ser Asp 
        995                 1000                 1005             


Ser Glu  Glu Pro Ser Lys Tyr  Ile Asn Ala Ser Phe  Ile Met Ser 
    1010                 1015                 1020             


Tyr Trp  Lys Pro Glu Val Met  Ile Ala Ala Gln Gly  Pro Leu Lys 
    1025                 1030                 1035             


Glu Thr  Ile Gly Asp Phe Trp  Gln Met Ile Phe Gln  Arg Lys Val 
    1040                 1045                 1050             


Lys Val  Ile Val Met Leu Thr  Glu Leu Lys His Gly  Asp Gln Glu 
    1055                 1060                 1065             


Ile Cys  Ala Gln Tyr Trp Gly  Glu Gly Lys Gln Thr  Tyr Gly Asp 
    1070                 1075                 1080             


Ile Glu  Val Asp Leu Lys Asp  Thr Asp Lys Ser Ser  Thr Tyr Thr 
    1085                 1090                 1095             


Leu Arg  Val Phe Glu Leu Arg  His Ser Lys Arg Lys  Asp Ser Arg 
    1100                 1105                 1110             


Thr Val  Tyr Gln Tyr Gln Tyr  Thr Asn Trp Ser Val  Glu Gln Leu 
    1115                 1120                 1125             


Pro Ala  Glu Pro Lys Glu Leu  Ile Ser Met Ile Gln  Val Val Lys 
    1130                 1135                 1140             


Gln Lys  Leu Pro Gln Lys Asn  Ser Ser Glu Gly Asn  Lys His His 
    1145                 1150                 1155             


Lys Ser  Thr Pro Leu Leu Ile  His Cys Arg Asp Gly  Ser Gln Gln 
    1160                 1165                 1170             


Thr Gly  Ile Phe Cys Ala Leu  Leu Asn Leu Leu Glu  Ser Ala Glu 
    1175                 1180                 1185             


Thr Glu  Glu Val Val Asp Ile  Phe Gln Val Val Lys  Ala Leu Arg 
    1190                 1195                 1200             


Lys Ala  Arg Pro Gly Met Val  Ser Thr Phe Glu Gln  Tyr Gln Phe 
    1205                 1210                 1215             


Leu Tyr  Asp Val Ile Ala Ser  Thr Tyr Pro Ala Gln  Asn Gly Gln 
    1220                 1225                 1230             


Val Lys  Lys Asn Asn His Gln  Glu Asp Lys Ile Glu  Phe Asp Asn 
    1235                 1240                 1245             


Glu Val  Asp Lys Val Lys Gln  Asp Ala Asn Cys Val  Asn Pro Leu 
    1250                 1255                 1260             


Gly Ala  Pro Glu Lys Leu Pro  Glu Ala Lys Glu Gln  Ala Glu Gly 
    1265                 1270                 1275             


Ser Glu  Pro Thr Ser Gly Thr  Glu Gly Pro Glu His  Ser Val Asn 
    1280                 1285                 1290             


Gly Pro  Ala Ser Pro Ala Leu  Asn Gln Gly Ser 
    1295                 1300                 


