                               SEQUENCE LISTING

<110> CARIBOU BIOSCIENCES, INC.
 
<120> DNA-GUIDED DNA INTERFERENCE BY A PROKARYOTIC ARGONAUTE

<130> 44287-724.601 

<140> PCT/US2014/033885
<141> 2014-04-11

<150> 14/250,224
<151> 2014-04-10

<150> 61/939,680
<151> 2014-02-13

<150> GB 1306574.3
<151> 2013-04-11

<160> 125

<170> PatentIn version 3.5

<210> 1
<211> 33
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      primer

<400> 1
aaaaaaaagc ttcctcaacg gggaggttcc gga                                    33


<210> 2
<211> 35
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      primer

<400> 2
aaaaaagtcg acgctcagat ttgcatagga gctgc                                  35


<210> 3
<211> 33
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      primer

<400> 3
aaaaaagtcg acatggcaag ctggagccac ccg                                    33


<210> 4
<211> 36
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      primer

<400> 4
aaaaaatcta gactaaacga agaagagctt ttcccg                                 36


<210> 5
<211> 32
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      primer

<400> 5
aaaaaatcta gatgcccaag cggggcggaa cc                                     32


<210> 6
<211> 33
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      primer

<400> 6
aaaaaagaat tcggtcaatc cgccccgctt cca                                    33


<210> 7
<211> 34
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      primer

<400> 7
ggccgtctag acccgggagt ataacagaaa cctt                                   34


<210> 8
<211> 35
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      primer

<400> 8
gcgcgtctag atcaaaatgg tatgcgtttt gacac                                  35


<210> 9
<211> 36
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      primer

<400> 9
gcgcgcggta ccagatgaac caccttggaa aaacgg                                 36


<210> 10
<211> 43
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      primer

<400> 10
gcgcgcgcgg ccgcgaattc ctaaacgaag aagagctttt ccc                         43


<210> 11
<211> 32
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      primer

<400> 11
gcgcgcacat gtcaagctgg agccacccgc ag                                     32


<210> 12
<211> 32
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      primer

<400> 12
gcgcgcccta ggttaattag tggtggtgat gg                                     32


<210> 13
<211> 48
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      primer


<220>
<221> modified_base
<222> (21)..(21)
<223> Inosine

<400> 13
ggcggagctc gccgtgggct ntgccgccgg cggaagggag tcctttcg                    48


<210> 14
<211> 48
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      primer

<400> 14
cgaaaggact cccttccgcc ggcggcaaag cccacggcga gctccgcc                    48


<210> 15
<211> 44
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      primer

<400> 15
cccgggtcct cctccttcgg gccggccgcg tgccccagga cgag                        44


<210> 16
<211> 44
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      primer

<400> 16
ctcgtcctgg ggcacgcggc cggcccgaag gaggaggacc cggg                        44


<210> 17
<211> 98
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      primer

<400> 17
ggccatttaa ttaaattaaa agcttgaatg caatatttat ttaaaaattt atacgaggta       60

gtaggttgta tagtatatta aattatttaa atataaag                               98


<210> 18
<211> 98
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      primer

<400> 18
tcgactttat atttaaataa tttaatatac tatacaacct actacctcgt ataaattttt       60

aaataaatat tgcattcaag cttttaattt aattaaat                               98


<210> 19
<211> 98
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      primer

<400> 19
ggccaggtcc accatgcgta agcttgaatg ccggccagcc caagggctct gcacgaggta       60

gtaggttgta tagttgctgg caggcgtagg tctaagcg                               98


<210> 20
<211> 98
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      primer

<400> 20
tcgacgctta gacctacgcc tgccagcaac tatacaacct actacctcgt gcagagccct       60

tgggctggcc ggcattcaag cttacgcatg gtggacct                               98


<210> 21
<211> 21
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      primer

<220>
<223> 5'-phosphate

<400> 21
tgaggtagta ggttgtatag t                                                 21


<210> 22
<211> 21
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      primer

<220>
<223> 5'-phosphate

<400> 22
ttatacaacc tactacctcg t                                                 21


<210> 23
<211> 6
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      6xHis tag

<400> 23
His His His His His His 
1               5       


<210> 24
<211> 9
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      9xHis tag

<400> 24
His His His His His His His His His 
1               5                   


<210> 25
<211> 50
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      polypeptide


<220>
<221> misc_feature
<222> (1)..(50)
<223> This sequence may encompass 3-50 "Arg" residues, wherein
      some positions may be absent

<400> 25
Arg Arg Arg Arg Arg Arg Arg Arg Arg Arg Arg Arg Arg Arg Arg Arg 
1               5                   10                  15      


Arg Arg Arg Arg Arg Arg Arg Arg Arg Arg Arg Arg Arg Arg Arg Arg 
            20                  25                  30          


Arg Arg Arg Arg Arg Arg Arg Arg Arg Arg Arg Arg Arg Arg Arg Arg 
        35                  40                  45              


Arg Arg 
    50  


<210> 26
<211> 9
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      peptide

<400> 26
Arg Arg Arg Arg Arg Arg Arg Arg Arg 
1               5                   


<210> 27
<211> 9
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      peptide

<400> 27
Glu Glu Glu Glu Glu Glu Glu Glu Glu 
1               5                   


<210> 28
<211> 4
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      peptide

<400> 28
Asp Glu Asp Asp 
1               


<210> 29
<211> 34
<212> PRT
<213> Xanthomonas sp.

<400> 29
Leu Thr Pro Glu Gln Val Val Ala Ile Ala Ser His Asp Gly Gly Lys 
1               5                   10                  15      


Gln Ala Leu Glu Thr Val Gln Arg Leu Leu Pro Val Leu Cys Gln Ala 
            20                  25                  30          


His Gly 
        


<210> 30
<211> 7
<212> PRT
<213> Unknown

<220>
<223> Description of Unknown: Nuclear 
      localization signal peptide

<400> 30
Pro Lys Lys Lys Arg Lys Val 
1               5           


<210> 31
<211> 21
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide

<220>
<223> 5'-phosphate

<400> 31
agaggtagta ggttgtatag t                                                 21


<210> 32
<211> 11
<212> PRT
<213> Aquifex aeolicus

<400> 32
Ala Phe Val Gly Ile Asp Ile Ser Arg Ile Thr 
1               5                   10      


<210> 33
<211> 9
<212> PRT
<213> Aquifex aeolicus

<400> 33
Ser Lys Ile Val Val His Arg Asp Gly 
1               5                   


<210> 34
<211> 9
<212> PRT
<213> Aquifex aeolicus

<400> 34
Asp Glu Val Ala Ala Phe Lys Lys Tyr 
1               5                   


<210> 35
<211> 11
<212> PRT
<213> Lyngbya sp.

<400> 35
Tyr Phe Ile Gly Leu Asp Ile Ser Arg Thr Pro 
1               5                   10      


<210> 36
<211> 9
<212> PRT
<213> Lyngbya sp.

<400> 36
Lys Thr Val Leu Ile Tyr Arg Asp Gly 
1               5                   


<210> 37
<211> 9
<212> PRT
<213> Lyngbya sp.

<400> 37
Asp Glu Ile Lys His Leu Arg Glu Arg 
1               5                   


<210> 38
<211> 11
<212> PRT
<213> Microcycstis aeruginosa

<400> 38
Tyr Phe Ile Gly Leu Asp Val Gly Arg Met Pro 
1               5                   10      


<210> 39
<211> 8
<212> PRT
<213> Microcycstis aeruginosa

<400> 39
Thr Val Leu Ile Tyr Arg Asp Gly 
1               5               


<210> 40
<211> 9
<212> PRT
<213> Microcycstis aeruginosa

<400> 40
Lys Glu Val Asp Asn Leu Leu Ala Arg 
1               5                   


<210> 41
<211> 11
<212> PRT
<213> Microcycstis aeruginosa

<400> 41
Tyr Phe Ile Gly Leu Asp Val Gly Arg Met Pro 
1               5                   10      


<210> 42
<211> 8
<212> PRT
<213> Microcycstis aeruginosa

<400> 42
Thr Val Leu Ile Tyr Arg Asp Gly 
1               5               


<210> 43
<211> 9
<212> PRT
<213> Microcycstis aeruginosa

<400> 43
Lys Glu Val Glu Asn Leu Leu Ala Arg 
1               5                   


<210> 44
<211> 11
<212> PRT
<213> Clostridium bartlettii

<400> 44
Cys Tyr Ile Gly Leu Asp Val Cys Arg Glu Asn 
1               5                   10      


<210> 45
<211> 9
<212> PRT
<213> Clostridium bartlettii

<400> 45
Glu His Ile Val Phe His Arg Asp Gly 
1               5                   


<210> 46
<211> 9
<212> PRT
<213> Clostridium bartlettii

<400> 46
Glu Asp Ile Asp Leu Leu Lys Glu Ile 
1               5                   


<210> 47
<211> 11
<212> PRT
<213> Exiguobacterium sp.

<400> 47
Cys Phe Val Gly Leu Asp Val Ser His Glu Asn 
1               5                   10      


<210> 48
<211> 9
<212> PRT
<213> Exiguobacterium sp.

<400> 48
Lys His Ile Thr Phe His Arg Asp Gly 
1               5                   


<210> 49
<211> 9
<212> PRT
<213> Exiguobacterium sp.

<400> 49
Glu Asp Leu Thr Leu Ile Asp Ser Ile 
1               5                   


<210> 50
<211> 11
<212> PRT
<213> Anoxybacillus flavithermus

<400> 50
Cys Phe Ile Gly Leu Asp Val Ser His Glu Gln 
1               5                   10      


<210> 51
<211> 9
<212> PRT
<213> Anoxybacillus flavithermus

<400> 51
Ser His Ile Thr Phe His Arg Asp Gly 
1               5                   


<210> 52
<211> 9
<212> PRT
<213> Anoxybacillus flavithermus

<400> 52
Glu Asp Leu Ala His Leu Thr Gln Tyr 
1               5                   


<210> 53
<211> 11
<212> PRT
<213> Halogeometricum borinquense

<400> 53
Ala Phe Val Gly Leu Asp Val Thr Tyr Asp His 
1               5                   10      


<210> 54
<211> 9
<212> PRT
<213> Halogeometricum borinquense

<400> 54
Arg His Val Val Ile His Arg Asp Gly 
1               5                   


<210> 55
<211> 9
<212> PRT
<213> Halogeometricum borinquense

<400> 55
Leu Asp Ile Glu Ser Leu Ile Lys Arg 
1               5                   


<210> 56
<211> 11
<212> PRT
<213> Halorubrum lacusprofundi

<400> 56
Leu Phe Ile Gly Ile Asp Val Ser His Arg Tyr 
1               5                   10      


<210> 57
<211> 9
<212> PRT
<213> Halorubrum lacusprofundi

<400> 57
Asp Arg Ile Val Ile His Arg Asp Gly 
1               5                   


<210> 58
<211> 9
<212> PRT
<213> Halorubrum lacusprofundi

<400> 58
Glu Asp Leu Asp Gln Val Glu Glu Met 
1               5                   


<210> 59
<211> 11
<212> PRT
<213> Aromatoleum aromaticum

<400> 59
Leu Phe Ile Gly Leu Asp Leu Gly Gly Val Ser 
1               5                   10      


<210> 60
<211> 9
<212> PRT
<213> Aromatoleum aromaticum

<400> 60
Arg Arg Ile Ala Leu His Arg Asp Gly 
1               5                   


<210> 61
<211> 9
<212> PRT
<213> Aromatoleum aromaticum

<400> 61
Glu Ser Leu Asp Val Ile Arg Asn Phe 
1               5                   


<210> 62
<211> 11
<212> PRT
<213> Thermus thermophilus

<400> 62
Leu Ala Val Gly Phe Asp Ala Gly Gly Arg Glu 
1               5                   10      


<210> 63
<211> 9
<212> PRT
<213> Thermus thermophilus

<400> 63
Ser Arg Val Leu Leu Leu Arg Asp Gly 
1               5                   


<210> 64
<211> 9
<212> PRT
<213> Thermus thermophilus

<400> 64
Asp Glu Phe Ala Leu Ala Leu Glu Ala 
1               5                   


<210> 65
<211> 11
<212> PRT
<213> Thermus thermophilus

<400> 65
Leu Ala Val Gly Phe Asp Ala Gly Gly Arg Glu 
1               5                   10      


<210> 66
<211> 9
<212> PRT
<213> Thermus thermophilus

<400> 66
Ser Arg Val Leu Leu Leu Arg Asp Gly 
1               5                   


<210> 67
<211> 9
<212> PRT
<213> Thermus thermophilus

<400> 67
Asp Glu Phe Ala Leu Ala Leu Glu Ala 
1               5                   


<210> 68
<211> 11
<212> PRT
<213> Synechococcus sp.

<400> 68
Leu Val Ile Gly Phe Asp Ala Gly Arg Asn Glu 
1               5                   10      


<210> 69
<211> 9
<212> PRT
<213> Synechococcus sp.

<400> 69
Lys Arg Ile Leu Leu Met Arg Asp Gly 
1               5                   


<210> 70
<211> 9
<212> PRT
<213> Synechococcus sp.

<400> 70
Gln Glu Phe Ser Leu Ile Thr Glu Ala 
1               5                   


<210> 71
<211> 11
<212> PRT
<213> Thermosynechococcus elongatus

<400> 71
Leu Ile Ile Gly Phe Asp Thr Ser Thr Asn Arg 
1               5                   10      


<210> 72
<211> 9
<212> PRT
<213> Thermosynechococcus elongatus

<400> 72
Lys Lys Ile Leu Leu Met Arg Asp Gly 
1               5                   


<210> 73
<211> 10
<212> PRT
<213> Thermosynechococcus elongatus

<400> 73
Gly Glu Phe Glu Gln Thr Ile Arg Glu Leu 
1               5                   10  


<210> 74
<211> 11
<212> PRT
<213> Synechococcus elongatus

<400> 74
Leu Ile Ile Gly Phe Asp Thr Gly Thr Asn Arg 
1               5                   10      


<210> 75
<211> 9
<212> PRT
<213> Synechococcus elongatus

<400> 75
Gln Lys Leu Leu Leu Met Arg Asp Gly 
1               5                   


<210> 76
<211> 9
<212> PRT
<213> Synechococcus elongatus

<400> 76
Gly Glu Phe Gln Gln Thr Ile Glu Leu 
1               5                   


<210> 77
<211> 11
<212> PRT
<213> Synechococcus sp.

<400> 77
Leu Thr Ile Gly Phe Asp Val Gly Thr Asn Arg 
1               5                   10      


<210> 78
<211> 9
<212> PRT
<213> Synechococcus sp.

<400> 78
Arg Lys Val Leu Leu Met Arg Asp Gly 
1               5                   


<210> 79
<211> 10
<212> PRT
<213> Synechococcus sp.

<400> 79
Gly Glu Phe Asp Lys Thr Ile Glu Glu Leu 
1               5                   10  


<210> 80
<211> 11
<212> PRT
<213> Synechococcus sp.

<400> 80
Leu Ile Ile Gly Phe Asp Val Gly Thr Asn Arg 
1               5                   10      


<210> 81
<211> 9
<212> PRT
<213> Synechococcus sp.

<400> 81
Ser Lys Val Leu Leu Met Arg Asp Gly 
1               5                   


<210> 82
<211> 10
<212> PRT
<213> Synechococcus sp.

<400> 82
Gly Glu Phe Ser Arg Thr Ile Glu Glu Leu 
1               5                   10  


<210> 83
<211> 11
<212> PRT
<213> Synechococcus elongatus

<400> 83
Leu Ile Ile Gly Phe Asp Thr Gly Thr Asn Arg 
1               5                   10      


<210> 84
<211> 9
<212> PRT
<213> Synechococcus elongatus

<400> 84
Gln Lys Leu Leu Leu Met Arg Asp Gly 
1               5                   


<210> 85
<211> 9
<212> PRT
<213> Synechococcus elongatus

<400> 85
Gly Glu Phe Gln Gln Thr Ile Glu Leu 
1               5                   


<210> 86
<211> 45
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide

<400> 86
aaacgacggc cagtgccaag cttactatac aacctactac ctcat                       45


<210> 87
<211> 21
<212> RNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide

<220>
<223> 5'-phosphate

<400> 87
ugagguagua gguuguauag u                                                 21


<210> 88
<211> 21
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide

<400> 88
actatacaac ctactacctc g                                                 21


<210> 89
<211> 22
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide

<400> 89
actatacaac ctactacctc gt                                                22


<210> 90
<211> 22
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide

<400> 90
acgaggtagt aggttgtata gt                                                22


<210> 91
<211> 21
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide

<400> 91
acgaggtagt aggttgtata g                                                 21


<210> 92
<211> 21
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide

<220>
<223> 5'-phosphate

<400> 92
ggaggtagta ggttgtatag t                                                 21


<210> 93
<211> 21
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide

<220>
<223> 5'-phosphate

<400> 93
cgaggtagta ggttgtatag t                                                 21


<210> 94
<211> 103
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      polynucleotide

<400> 94
gtcgacttta tatttaaata atttaatata ctatacaacc tactacctcg tataaatttt       60

taaataaata ttgcattcaa gcttttaatt taattaaatg gcc                        103


<210> 95
<211> 103
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      polynucleotide

<400> 95
ggccatttaa ttaaattaaa agcttgaatg caatatttat ttaaaaattt atacgaggta       60

gtaggttgta tagtatatta aattatttaa atataaagtc gac                        103


<210> 96
<211> 103
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      polynucleotide

<400> 96
gtcgacgctt agacctacgc ctgccagcaa ctatacaacc tactacctcg tgcagagccc       60

ttgggctggc cggcattcaa gcttacgcat ggtggacctg gcc                        103


<210> 97
<211> 103
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      polynucleotide

<400> 97
ggccaggtcc accatgcgta agcttgaatg ccggccagcc caagggctct gcacgaggta       60

gtaggttgta tagttgctgg caggcgtagg tctaagcgtc gac                        103


<210> 98
<211> 10
<212> PRT
<213> Thermus thermophilus

<400> 98
Ala Phe Gly Ala Ser Gly Ala Ser Leu Arg 
1               5                   10  


<210> 99
<211> 10
<212> PRT
<213> Thermus thermophilus

<400> 99
Ala Gln Glu Thr Ala Leu Ala Leu Leu Arg 
1               5                   10  


<210> 100
<211> 10
<212> PRT
<213> Thermus thermophilus

<400> 100
Ala Val Ser Lys Pro Ala Asp Ala Leu Arg 
1               5                   10  


<210> 101
<211> 11
<212> PRT
<213> Thermus thermophilus

<400> 101
Glu Gly Ile Ala Tyr Asp Leu Val Ser Val Arg 
1               5                   10      


<210> 102
<211> 8
<212> PRT
<213> Thermus thermophilus

<400> 102
Glu Ile Ala Ser Trp Ile Gly Arg 
1               5               


<210> 103
<211> 12
<212> PRT
<213> Thermus thermophilus

<400> 103
Leu Ala Asp Gly Leu Tyr Val Pro Leu Glu Asp Lys 
1               5                   10          


<210> 104
<211> 7
<212> PRT
<213> Thermus thermophilus

<400> 104
Leu Gly Glu Glu Asp Pro Lys 
1               5           


<210> 105
<211> 10
<212> PRT
<213> Thermus thermophilus

<400> 105
Leu Gly Leu Gly Thr Pro Glu Ala Val Arg 
1               5                   10  


<210> 106
<211> 11
<212> PRT
<213> Thermus thermophilus

<400> 106
Leu Tyr Pro Ala Ser Gly Phe Ala Phe Pro Arg 
1               5                   10      


<210> 107
<211> 8
<212> PRT
<213> Thermus thermophilus

<400> 107
Met Gly Gln Asn Tyr Ala Tyr Arg 
1               5               


<210> 108
<211> 8
<212> PRT
<213> Thermus thermophilus

<400> 108
Ser Val Leu Ser Ala Leu Ala Arg 
1               5               


<210> 109
<211> 7
<212> PRT
<213> Thermus thermophilus

<400> 109
Thr Glu Val Phe Leu Asn Arg 
1               5           


<210> 110
<211> 11
<212> PRT
<213> Thermus thermophilus

<400> 110
Val Ala Trp Val Ala Asp Pro Lys Asp Pro Arg 
1               5                   10      


<210> 111
<211> 7
<212> PRT
<213> Thermus thermophilus

<400> 111
Val Tyr Pro Val Gln Gly Arg 
1               5           


<210> 112
<211> 48
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide

<400> 112
ggcggagctc gccgtgggct ttgccgccgg cggaagggag tcctttcg                    48


<210> 113
<211> 37
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide

<400> 113
gagagaggat cccgaattgt gcagctgtca atcaacc                                37


<210> 114
<211> 40
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<221> modified_base
<222> (40)..(40)
<223> a, c, t, g, unknown or other

<400> 114
gagagaggat cctttttttt tttttttttt ttttttttvn                             40


<210> 115
<211> 27
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide

<400> 115
ctagacgagg tagtaggttg tatagta                                           27


<210> 116
<211> 27
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide

<400> 116
agcttactat acaacctact acctcgt                                           27


<210> 117
<211> 685
<212> PRT
<213> Thermus thermophilus

<400> 117
Met Asn His Leu Gly Lys Thr Glu Val Phe Leu Asn Arg Phe Ala Leu 
1               5                   10                  15      


Arg Pro Leu Asn Pro Glu Glu Leu Arg Pro Trp Arg Leu Glu Val Val 
            20                  25                  30          


Leu Asp Pro Pro Pro Gly Arg Glu Glu Val Tyr Pro Leu Leu Ala Gln 
        35                  40                  45              


Val Ala Arg Arg Ala Gly Gly Val Thr Val Arg Met Gly Asp Gly Leu 
    50                  55                  60                  


Ala Ser Trp Ser Pro Pro Glu Val Leu Val Leu Glu Gly Thr Leu Ala 
65                  70                  75                  80  


Arg Met Gly Gln Thr Tyr Ala Tyr Arg Leu Tyr Pro Lys Gly Arg Arg 
                85                  90                  95      


Pro Leu Asp Pro Lys Asp Pro Gly Glu Arg Ser Val Leu Ser Ala Leu 
            100                 105                 110         


Ala Arg Arg Leu Leu Gln Glu Arg Leu Arg Arg Leu Glu Gly Val Trp 
        115                 120                 125             


Val Glu Gly Leu Ala Val Tyr Arg Arg Glu His Ala Arg Gly Pro Gly 
    130                 135                 140                 


Trp Arg Val Leu Gly Gly Ala Val Leu Asp Leu Trp Val Ser Asp Ser 
145                 150                 155                 160 


Gly Ala Phe Leu Leu Glu Val Asp Pro Ala Tyr Arg Ile Leu Cys Glu 
                165                 170                 175     


Met Ser Leu Glu Ala Trp Leu Ala Gln Gly His Pro Leu Pro Lys Arg 
            180                 185                 190         


Val Arg Asn Ala Tyr Asp Arg Arg Thr Trp Glu Leu Leu Arg Leu Gly 
        195                 200                 205             


Glu Glu Asp Pro Lys Glu Leu Pro Leu Pro Gly Gly Leu Ser Leu Leu 
    210                 215                 220                 


Asp Tyr His Ala Ser Lys Gly Arg Leu Gln Gly Arg Glu Gly Gly Arg 
225                 230                 235                 240 


Val Ala Trp Val Ala Asp Pro Lys Asp Pro Arg Lys Pro Ile Pro His 
                245                 250                 255     


Leu Thr Gly Leu Leu Val Pro Val Leu Thr Leu Glu Asp Leu His Glu 
            260                 265                 270         


Glu Glu Gly Ser Leu Ala Leu Ser Leu Pro Trp Glu Glu Arg Arg Arg 
        275                 280                 285             


Arg Thr Arg Glu Ile Ala Ser Trp Ile Gly Arg Arg Leu Gly Leu Gly 
    290                 295                 300                 


Thr Pro Glu Ala Val Arg Ala Gln Ala Tyr Arg Leu Ser Ile Pro Lys 
305                 310                 315                 320 


Leu Met Gly Arg Arg Ala Val Ser Lys Pro Ala Asp Ala Leu Arg Val 
                325                 330                 335     


Gly Phe Tyr Arg Ala Gln Glu Thr Ala Leu Ala Leu Leu Arg Leu Asp 
            340                 345                 350         


Gly Ala Gln Gly Trp Pro Glu Phe Leu Arg Arg Ala Leu Leu Arg Ala 
        355                 360                 365             


Phe Gly Ala Ser Gly Ala Ser Leu Arg Leu His Thr Leu His Ala His 
    370                 375                 380                 


Pro Ser Gln Gly Leu Ala Phe Arg Glu Ala Leu Arg Lys Ala Lys Glu 
385                 390                 395                 400 


Glu Gly Val Gln Ala Val Leu Val Leu Thr Pro Pro Met Ala Trp Glu 
                405                 410                 415     


Asp Arg Asn Arg Leu Lys Ala Leu Leu Leu Arg Glu Gly Leu Pro Ser 
            420                 425                 430         


Gln Ile Leu Asn Val Pro Leu Arg Glu Glu Glu Arg His Arg Trp Glu 
        435                 440                 445             


Asn Ala Leu Leu Gly Leu Leu Ala Lys Ala Gly Leu Gln Val Val Ala 
    450                 455                 460                 


Leu Ser Gly Ala Tyr Pro Ala Glu Leu Ala Val Gly Phe Asp Ala Gly 
465                 470                 475                 480 


Gly Arg Glu Ser Phe Arg Phe Gly Gly Ala Ala Cys Ala Val Gly Gly 
                485                 490                 495     


Asp Gly Gly His Leu Leu Trp Thr Leu Pro Glu Ala Gln Ala Gly Glu 
            500                 505                 510         


Arg Ile Pro Gln Glu Val Val Trp Asp Leu Leu Glu Glu Thr Leu Trp 
        515                 520                 525             


Ala Phe Arg Arg Lys Ala Gly Arg Leu Pro Ser Arg Val Leu Leu Leu 
    530                 535                 540                 


Arg Asp Gly Arg Val Pro Gln Asp Glu Phe Ala Leu Ala Leu Glu Ala 
545                 550                 555                 560 


Leu Ala Arg Glu Gly Ile Ala Tyr Asp Leu Val Ser Val Arg Lys Ser 
                565                 570                 575     


Gly Gly Gly Arg Val Tyr Pro Val Gln Gly Arg Leu Ala Asp Gly Leu 
            580                 585                 590         


Tyr Val Pro Leu Glu Asp Lys Thr Phe Leu Leu Leu Thr Val His Arg 
        595                 600                 605             


Asp Phe Arg Gly Thr Pro Arg Pro Leu Lys Leu Val His Glu Ala Gly 
    610                 615                 620                 


Asp Thr Pro Leu Glu Ala Leu Ala His Gln Ile Phe His Leu Thr Arg 
625                 630                 635                 640 


Leu Tyr Pro Ala Ser Gly Phe Ala Phe Pro Arg Leu Pro Ala Pro Leu 
                645                 650                 655     


His Leu Ala Asp Arg Leu Val Lys Glu Val Gly Arg Leu Gly Ile Arg 
            660                 665                 670         


His Leu Lys Glu Val Asp Arg Glu Lys Leu Phe Phe Val 
        675                 680                 685 


<210> 118
<211> 660
<212> PRT
<213> Thermus thermophilus

<400> 118
Met Asn His Leu Gly Lys Thr Glu Val Phe Leu Asn Arg Phe Ala Leu 
1               5                   10                  15      


Arg Pro Leu Asn Pro Glu Glu Leu Arg Pro Trp Arg Leu Glu Val Val 
            20                  25                  30          


Leu Asp Pro Pro Pro Gly Arg Glu Glu Val Tyr Pro Leu Leu Ala Gln 
        35                  40                  45              


Val Ala Arg Arg Ala Gly Gly Val Thr Val Arg Met Gly Asp Gly Leu 
    50                  55                  60                  


Ala Ser Trp Ser Pro Pro Glu Val Leu Val Leu Glu Gly Thr Leu Ala 
65                  70                  75                  80  


Arg Met Gly Gln Thr Tyr Ala Tyr Arg Leu Tyr Pro Lys Gly Arg Arg 
                85                  90                  95      


Pro Leu Asp Pro Lys Asp Pro Gly Glu Arg Ser Ala Leu Ser Ser Leu 
            100                 105                 110         


Ala Arg Arg Leu Leu Gln Glu Arg Leu Arg Arg Leu Glu Gly Val Trp 
        115                 120                 125             


Val Glu Gly Leu Ala Val Tyr Arg Arg Glu His Ala Arg Gly Pro Gly 
    130                 135                 140                 


Trp Arg Val Leu Gly Gly Ala Val Leu Asp Leu Trp Val Ser Asp Ser 
145                 150                 155                 160 


Gly Ala Phe Leu Leu Glu Val Asp Pro Ala Tyr Arg Ile Leu Cys Glu 
                165                 170                 175     


Met Ser Leu Glu Ala Trp Leu Ala Gln Gly His Pro Leu Pro Lys Arg 
            180                 185                 190         


Val Arg Asn Ala Tyr Asp Arg Arg Thr Trp Glu Leu Leu Arg Leu Gly 
        195                 200                 205             


Glu Glu Asp Pro Lys Glu Leu Pro Leu Pro Gly Gly Leu Ser Leu Leu 
    210                 215                 220                 


Asp Tyr His Ala Ser Lys Gly Arg Leu Gln Gly Arg Glu Gly Gly Arg 
225                 230                 235                 240 


Val Ala Trp Val Ala Asp Pro Lys Asp Pro Arg Lys Pro Ile Pro His 
                245                 250                 255     


Leu Thr Gly Leu Leu Val Pro Val Leu Thr Leu Glu Asp Leu His Glu 
            260                 265                 270         


Glu Glu Gly Gly Leu Ala Leu Ser Leu Pro Trp Glu Glu Arg Arg Arg 
        275                 280                 285             


Arg Thr Arg Glu Ile Ala Ser Trp Ile Gly Arg Arg Leu Gly Leu Gly 
    290                 295                 300                 


Thr Pro Glu Ala Val Arg Ala Gln Ala Tyr Arg Leu Ser Ile Pro Lys 
305                 310                 315                 320 


Leu Met Gly Arg Arg Ala Val Ser Lys Pro Ala Asp Ala Leu Arg Val 
                325                 330                 335     


Gly Leu Tyr Arg Ala Gln Glu Thr Ala Leu Ala Leu Leu Arg Leu Asp 
            340                 345                 350         


Gly Ala Gln Gly Trp Pro Glu Phe Leu Arg Arg Ala Leu Leu Gln Ala 
        355                 360                 365             


Phe Gly Ala Gly Gly Ala Ser Leu Arg Leu His Thr Leu His Ala His 
    370                 375                 380                 


Pro Ser Gln Gly Leu Ala Phe Arg Glu Ala Leu Arg Lys Ala Lys Glu 
385                 390                 395                 400 


Lys Gly Val Gln Ala Val Leu Val Leu Thr Pro Pro Met Ala Trp Glu 
                405                 410                 415     


Asp Arg Asn Arg Leu Lys Ala Leu Leu Leu Arg Glu Gly Leu Pro Ser 
            420                 425                 430         


Gln Ile Leu Asn Val Pro Leu Arg Glu Glu Glu Arg His Arg Trp Glu 
        435                 440                 445             


Asn Ala Leu Leu Gly Leu Leu Ala Lys Ala Gly Leu Gln Val Val Ala 
    450                 455                 460                 


Leu Ser Gly Ala Tyr Pro Ala Glu Leu Ala Val Gly Phe Asp Ala Gly 
465                 470                 475                 480 


Gly Arg Glu Ser Phe Arg Phe Gly Gly Ala Ala Cys Ala Val Gly Gly 
                485                 490                 495     


Asp Gly Gly His Leu Leu Trp Thr Leu Pro Glu Ala Gln Ala Gly Glu 
            500                 505                 510         


Arg Ile Pro Gln Glu Val Val Trp Asp Leu Leu Glu Glu Thr Leu Trp 
        515                 520                 525             


Ala Phe Arg Arg Lys Ala Gly Arg Leu Pro Ser Arg Val Leu Leu Leu 
    530                 535                 540                 


Arg Asp Gly Arg Val Pro Gln Asp Glu Phe Ala Leu Ala Leu Glu Ala 
545                 550                 555                 560 


Leu Ala Arg Glu Gly Ile Ala Tyr Asp Leu Val Ser Val Arg Lys Ser 
                565                 570                 575     


Gly Gly Gly Arg Val Tyr Pro Val Gln Gly Arg Leu Ala Asp Gly Leu 
            580                 585                 590         


Tyr Val Pro Leu Glu Asp Arg Thr Phe Leu Leu Leu Thr Val His Arg 
        595                 600                 605             


Asp Phe Arg Gly Thr Pro Arg Pro Leu Lys Leu Val His Glu Ala Gly 
    610                 615                 620                 


Asp Thr Pro Leu Glu Ala Leu Ala His Gln Ile Phe His Leu Thr Arg 
625                 630                 635                 640 


Leu Tyr Pro Ala Ser Gly Phe Ala Phe Pro Arg Leu Pro Ala Pro Leu 
                645                 650                 655     


His Leu Ala Asp 
            660 


<210> 119
<211> 706
<212> PRT
<213> Aquifex aeolicus

<400> 119
Met Gly Lys Glu Ala Leu Leu Asn Leu Tyr Arg Ile Glu Tyr Arg Pro 
1               5                   10                  15      


Lys Asp Thr Thr Phe Thr Val Phe Lys Pro Thr His Glu Ile Gln Lys 
            20                  25                  30          


Glu Lys Leu Asn Lys Val Arg Trp Arg Val Phe Leu Gln Thr Gly Leu 
        35                  40                  45              


Pro Thr Phe Arg Arg Glu Asp Glu Phe Trp Cys Ala Gly Lys Val Glu 
    50                  55                  60                  


Lys Asp Thr Leu Tyr Leu Thr Leu Ser Asn Gly Glu Ile Val Glu Leu 
65                  70                  75                  80  


Lys Arg Val Gly Glu Glu Glu Phe Arg Gly Phe Gln Asn Glu Arg Glu 
                85                  90                  95      


Cys Gln Glu Leu Phe Arg Asp Phe Leu Thr Lys Thr Lys Val Lys Asp 
            100                 105                 110         


Lys Phe Ile Ser Asp Phe Tyr Lys Lys Phe Arg Asp Lys Ile Thr Val 
        115                 120                 125             


Gln Gly Lys Asn Arg Lys Ile Ala Leu Ile Pro Glu Val Asn Glu Lys 
    130                 135                 140                 


Val Leu Lys Ser Glu Glu Gly Tyr Phe Leu Leu His Leu Asp Leu Lys 
145                 150                 155                 160 


Phe Arg Ile Gln Pro Phe Glu Thr Leu Gln Thr Leu Leu Glu Arg Asn 
                165                 170                 175     


Asp Phe Asn Pro Lys Arg Ile Arg Val Lys Pro Ile Gly Ile Asp Phe 
            180                 185                 190         


Val Gly Arg Val Gln Asp Val Phe Lys Ala Lys Glu Lys Gly Glu Glu 
        195                 200                 205             


Phe Phe Arg Leu Cys Met Glu Arg Ser Thr His Lys Ser Ser Lys Lys 
    210                 215                 220                 


Ala Trp Glu Glu Leu Leu Lys Asn Arg Glu Leu Arg Glu Lys Ala Phe 
225                 230                 235                 240 


Leu Val Val Leu Glu Lys Gly Tyr Thr Tyr Pro Ala Thr Ile Leu Lys 
                245                 250                 255     


Pro Val Leu Thr Tyr Glu Asn Leu Glu Asp Glu Glu Arg Asn Glu Val 
            260                 265                 270         


Ala Asp Ile Val Arg Met Glu Pro Gly Lys Arg Leu Asn Leu Ile Arg 
        275                 280                 285             


Tyr Ile Leu Arg Arg Tyr Val Lys Ala Leu Arg Asp Tyr Gly Trp Tyr 
    290                 295                 300                 


Ile Ser Pro Glu Glu Glu Arg Ala Lys Gly Lys Leu Asn Phe Lys Asp 
305                 310                 315                 320 


Thr Val Leu Asp Ala Lys Gly Lys Asn Thr Lys Val Ile Thr Asn Leu 
                325                 330                 335     


Arg Lys Phe Leu Glu Leu Cys Arg Pro Phe Val Lys Lys Asp Val Leu 
            340                 345                 350         


Ser Val Glu Ile Ile Ser Val Ser Val Tyr Lys Lys Leu Glu Trp Arg 
        355                 360                 365             


Lys Glu Glu Phe Leu Lys Glu Leu Ile Asn Phe Leu Lys Asn Lys Gly 
    370                 375                 380                 


Ile Lys Leu Lys Ile Lys Gly Lys Ser Leu Ile Leu Ala Gln Thr Arg 
385                 390                 395                 400 


Glu Glu Ala Lys Glu Lys Leu Ile Pro Val Ile Asn Lys Ile Lys Asp 
                405                 410                 415     


Val Asp Leu Val Ile Val Phe Leu Glu Glu Tyr Pro Lys Val Asp Pro 
            420                 425                 430         


Tyr Lys Ser Phe Leu Leu Tyr Asp Phe Val Lys Arg Glu Leu Leu Lys 
        435                 440                 445             


Lys Met Ile Pro Ser Gln Val Ile Leu Asn Arg Thr Leu Lys Asn Glu 
    450                 455                 460                 


Asn Leu Lys Phe Val Leu Leu Asn Val Ala Glu Gln Val Leu Ala Lys 
465                 470                 475                 480 


Thr Gly Asn Ile Pro Tyr Lys Leu Lys Glu Ile Glu Gly Lys Val Asp 
                485                 490                 495     


Ala Phe Val Gly Ile Asp Ile Ser Arg Ile Thr Arg Asp Gly Lys Thr 
            500                 505                 510         


Val Asn Ala Val Ala Phe Thr Lys Ile Phe Asn Ser Lys Gly Glu Leu 
        515                 520                 525             


Val Arg Tyr Tyr Leu Thr Ser Tyr Pro Ala Phe Gly Glu Lys Leu Thr 
    530                 535                 540                 


Glu Lys Ala Ile Gly Asp Val Phe Ser Leu Leu Glu Lys Leu Gly Phe 
545                 550                 555                 560 


Lys Lys Gly Ser Lys Ile Val Val His Arg Asp Gly Arg Leu Tyr Arg 
                565                 570                 575     


Asp Glu Val Ala Ala Phe Lys Lys Tyr Gly Glu Leu Tyr Gly Tyr Ser 
            580                 585                 590         


Leu Glu Leu Leu Glu Ile Ile Lys Arg Asn Asn Pro Arg Phe Phe Ser 
        595                 600                 605             


Asn Glu Lys Phe Ile Lys Gly Tyr Phe Tyr Lys Leu Ser Glu Asp Ser 
    610                 615                 620                 


Val Ile Leu Ala Thr Tyr Asn Gln Val Tyr Glu Gly Thr His Gln Pro 
625                 630                 635                 640 


Ile Lys Val Arg Lys Val Tyr Gly Glu Leu Pro Val Glu Val Leu Cys 
                645                 650                 655     


Ser Gln Ile Leu Ser Leu Thr Leu Met Asn Tyr Ser Ser Phe Gln Pro 
            660                 665                 670         


Ile Lys Leu Pro Ala Thr Val His Tyr Ser Asp Lys Ile Thr Lys Leu 
        675                 680                 685             


Met Leu Arg Gly Ile Glu Pro Ile Lys Lys Glu Gly Asp Ile Met Tyr 
    690                 695                 700                 


Trp Leu 
705     


<210> 120
<211> 770
<212> PRT
<213> Pyrococcus furiosus

<400> 120
Met Lys Ala Lys Val Val Ile Asn Leu Val Lys Ile Asn Lys Lys Ile 
1               5                   10                  15      


Ile Pro Asp Lys Ile Tyr Val Tyr Arg Leu Phe Asn Asp Pro Glu Glu 
            20                  25                  30          


Glu Leu Gln Lys Glu Gly Tyr Ser Ile Tyr Arg Leu Ala Tyr Glu Asn 
        35                  40                  45              


Val Gly Ile Val Ile Asp Pro Glu Asn Leu Ile Ile Ala Thr Thr Lys 
    50                  55                  60                  


Glu Leu Glu Tyr Glu Gly Glu Phe Ile Pro Glu Gly Glu Ile Ser Phe 
65                  70                  75                  80  


Ser Glu Leu Arg Asn Asp Tyr Gln Ser Lys Leu Val Leu Arg Leu Leu 
                85                  90                  95      


Lys Glu Asn Gly Ile Gly Glu Tyr Glu Leu Ser Lys Leu Leu Arg Lys 
            100                 105                 110         


Phe Arg Lys Pro Lys Thr Phe Gly Asp Tyr Lys Val Ile Pro Ser Val 
        115                 120                 125             


Glu Met Ser Val Ile Lys His Asp Glu Asp Phe Tyr Leu Val Ile His 
    130                 135                 140                 


Ile Ile His Gln Ile Gln Ser Met Lys Thr Leu Trp Glu Leu Val Asn 
145                 150                 155                 160 


Lys Asp Pro Lys Glu Leu Glu Glu Phe Leu Met Thr His Lys Glu Asn 
                165                 170                 175     


Leu Met Leu Lys Asp Ile Ala Ser Pro Leu Lys Thr Val Tyr Lys Pro 
            180                 185                 190         


Cys Phe Glu Glu Tyr Thr Lys Lys Pro Lys Leu Asp His Asn Gln Glu 
        195                 200                 205             


Ile Val Lys Tyr Trp Tyr Asn Tyr His Ile Glu Arg Tyr Trp Asn Thr 
    210                 215                 220                 


Pro Glu Ala Lys Leu Glu Phe Tyr Arg Lys Phe Gly Gln Val Asp Leu 
225                 230                 235                 240 


Lys Gln Pro Ala Ile Leu Ala Lys Phe Ala Ser Lys Ile Lys Lys Asn 
                245                 250                 255     


Lys Asn Tyr Lys Ile Tyr Leu Leu Pro Gln Leu Val Val Pro Thr Tyr 
            260                 265                 270         


Asn Ala Glu Gln Leu Glu Ser Asp Val Ala Lys Glu Ile Leu Glu Tyr 
        275                 280                 285             


Thr Lys Leu Met Pro Glu Glu Arg Lys Glu Leu Leu Glu Asn Ile Leu 
    290                 295                 300                 


Ala Glu Val Asp Ser Asp Ile Ile Asp Lys Ser Leu Ser Glu Ile Glu 
305                 310                 315                 320 


Val Glu Lys Ile Ala Gln Glu Leu Glu Asn Lys Ile Arg Val Arg Asp 
                325                 330                 335     


Asp Lys Gly Asn Ser Val Pro Ile Ser Gln Leu Asn Val Gln Lys Ser 
            340                 345                 350         


Gln Leu Leu Leu Trp Thr Asn Tyr Ser Arg Lys Tyr Pro Val Ile Leu 
        355                 360                 365             


Pro Tyr Glu Val Pro Glu Lys Phe Arg Lys Ile Arg Glu Ile Pro Met 
    370                 375                 380                 


Phe Ile Ile Leu Asp Ser Gly Leu Leu Ala Asp Ile Gln Asn Phe Ala 
385                 390                 395                 400 


Thr Asn Glu Phe Arg Glu Leu Val Lys Ser Met Tyr Tyr Ser Leu Ala 
                405                 410                 415     


Lys Lys Tyr Asn Ser Leu Ala Lys Lys Ala Arg Ser Thr Asn Glu Ile 
            420                 425                 430         


Gly Leu Pro Phe Leu Asp Phe Arg Gly Lys Glu Lys Val Ile Thr Glu 
        435                 440                 445             


Asp Leu Asn Ser Asp Lys Gly Ile Ile Glu Val Val Glu Gln Val Ser 
    450                 455                 460                 


Ser Phe Met Lys Gly Lys Glu Leu Gly Leu Ala Phe Ile Ala Ala Arg 
465                 470                 475                 480 


Asn Lys Leu Ser Ser Glu Lys Phe Glu Glu Ile Lys Arg Arg Leu Phe 
                485                 490                 495     


Asn Leu Asn Val Ile Ser Gln Val Val Asn Glu Asp Thr Leu Lys Asn 
            500                 505                 510         


Lys Arg Asp Lys Tyr Asp Arg Asn Arg Leu Asp Leu Phe Val Arg His 
        515                 520                 525             


Asn Leu Leu Phe Gln Val Leu Ser Lys Leu Gly Val Lys Tyr Tyr Val 
    530                 535                 540                 


Leu Asp Tyr Arg Phe Asn Tyr Asp Tyr Ile Ile Gly Ile Asp Val Ala 
545                 550                 555                 560 


Pro Met Lys Arg Ser Glu Gly Tyr Ile Gly Gly Ser Ala Val Met Phe 
                565                 570                 575     


Asp Ser Gln Gly Tyr Ile Arg Lys Ile Val Pro Ile Lys Ile Gly Glu 
            580                 585                 590         


Gln Arg Gly Glu Ser Val Asp Met Asn Glu Phe Phe Lys Glu Met Val 
        595                 600                 605             


Asp Lys Phe Lys Glu Phe Asn Ile Lys Leu Asp Asn Lys Lys Ile Leu 
    610                 615                 620                 


Leu Leu Arg Asp Gly Arg Ile Thr Asn Asn Glu Glu Glu Gly Leu Lys 
625                 630                 635                 640 


Tyr Ile Ser Glu Met Phe Asp Ile Glu Val Val Thr Met Asp Val Ile 
                645                 650                 655     


Lys Asn His Pro Val Arg Ala Phe Ala Asn Met Lys Met Tyr Phe Asn 
            660                 665                 670         


Leu Gly Gly Ala Ile Tyr Leu Ile Pro His Lys Leu Lys Gln Ala Lys 
        675                 680                 685             


Gly Thr Pro Ile Pro Ile Lys Leu Ala Lys Lys Arg Ile Ile Lys Asn 
    690                 695                 700                 


Gly Lys Val Glu Lys Gln Ser Ile Thr Arg Gln Asp Val Leu Asp Ile 
705                 710                 715                 720 


Phe Ile Leu Thr Arg Leu Asn Tyr Gly Ser Ile Ser Ala Asp Met Arg 
                725                 730                 735     


Leu Pro Ala Pro Val His Tyr Ala His Lys Phe Ala Asn Ala Ile Arg 
            740                 745                 750         


Asn Glu Trp Lys Ile Lys Glu Glu Phe Leu Ala Glu Gly Phe Leu Tyr 
        755                 760                 765             


Phe Val 
    770 


<210> 121
<211> 770
<212> PRT
<213> Pyrococcus furiosus

<400> 121
Met Lys Ala Lys Val Val Ile Asn Leu Val Lys Ile Asn Lys Lys Ile 
1               5                   10                  15      


Ile Pro Asp Lys Ile Tyr Val Tyr Arg Leu Phe Asn Asp Pro Glu Glu 
            20                  25                  30          


Glu Leu Gln Lys Glu Gly Tyr Ser Ile Tyr Arg Leu Ala Tyr Glu Asn 
        35                  40                  45              


Val Gly Ile Val Ile Asp Pro Glu Asn Leu Ile Ile Ala Thr Thr Lys 
    50                  55                  60                  


Glu Leu Glu Tyr Glu Gly Glu Phe Ile Pro Glu Gly Glu Ile Ser Phe 
65                  70                  75                  80  


Ser Glu Leu Arg Asn Asp Tyr Gln Ser Lys Leu Val Leu Arg Leu Leu 
                85                  90                  95      


Lys Glu Asn Gly Ile Gly Glu Tyr Glu Leu Ser Lys Leu Leu Arg Lys 
            100                 105                 110         


Phe Arg Lys Pro Lys Thr Phe Gly Asp Tyr Lys Val Ile Pro Ser Val 
        115                 120                 125             


Glu Met Ser Val Ile Lys His Asp Glu Asp Phe Tyr Leu Val Ile His 
    130                 135                 140                 


Ile Ile His Gln Ile Gln Ser Met Lys Thr Leu Trp Glu Leu Val Asn 
145                 150                 155                 160 


Lys Asp Pro Lys Glu Leu Glu Glu Phe Leu Met Thr His Lys Glu Asn 
                165                 170                 175     


Leu Met Leu Lys Asp Ile Ala Ser Pro Leu Lys Thr Val Tyr Lys Pro 
            180                 185                 190         


Cys Phe Glu Glu Tyr Thr Lys Lys Pro Lys Leu Asp His Asn Gln Glu 
        195                 200                 205             


Ile Val Lys Tyr Trp Tyr Asn Tyr His Ile Glu Arg Tyr Trp Asn Thr 
    210                 215                 220                 


Pro Glu Ala Lys Leu Glu Phe Tyr Arg Lys Phe Gly Gln Val Asp Leu 
225                 230                 235                 240 


Lys Gln Pro Ala Ile Leu Ala Lys Phe Ala Ser Lys Ile Lys Lys Asn 
                245                 250                 255     


Lys Asn Tyr Lys Ile Tyr Leu Leu Pro Gln Leu Val Val Pro Thr Tyr 
            260                 265                 270         


Asn Ala Glu Gln Leu Glu Ser Asp Val Ala Lys Glu Ile Leu Glu Tyr 
        275                 280                 285             


Thr Lys Leu Met Pro Glu Glu Arg Lys Glu Leu Leu Glu Asn Ile Leu 
    290                 295                 300                 


Ala Glu Val Asp Ser Asp Ile Ile Asp Lys Ser Leu Ser Glu Ile Glu 
305                 310                 315                 320 


Val Glu Lys Ile Ala Gln Glu Leu Glu Asn Lys Ile Arg Val Arg Asp 
                325                 330                 335     


Asp Lys Gly Asn Ser Val Pro Ile Ser Gln Leu Asn Val Gln Lys Ser 
            340                 345                 350         


Gln Leu Leu Leu Trp Thr Asn Tyr Ser Arg Lys Tyr Pro Val Ile Leu 
        355                 360                 365             


Pro Tyr Glu Val Pro Glu Lys Phe Arg Lys Ile Arg Glu Ile Pro Met 
    370                 375                 380                 


Phe Ile Ile Leu Asp Ser Gly Leu Leu Ala Asp Ile Gln Asn Phe Ala 
385                 390                 395                 400 


Thr Asn Glu Phe Arg Glu Leu Val Lys Ser Met Tyr Tyr Ser Leu Ala 
                405                 410                 415     


Lys Lys Tyr Asn Ser Leu Ala Lys Lys Ala Arg Ser Thr Asn Glu Ile 
            420                 425                 430         


Gly Leu Pro Phe Leu Asp Phe Arg Gly Lys Glu Lys Val Ile Thr Glu 
        435                 440                 445             


Asp Leu Asn Ser Asp Lys Gly Ile Ile Glu Val Val Glu Gln Val Ser 
    450                 455                 460                 


Ser Phe Met Lys Gly Lys Glu Leu Gly Leu Ala Phe Ile Ala Ala Arg 
465                 470                 475                 480 


Asn Lys Leu Ser Ser Glu Lys Phe Glu Glu Ile Lys Arg Arg Leu Phe 
                485                 490                 495     


Asn Leu Asn Val Ile Ser Gln Val Val Asn Glu Asp Thr Leu Lys Asn 
            500                 505                 510         


Lys Arg Asp Lys Tyr Asp Arg Asn Arg Leu Asp Leu Phe Val Arg His 
        515                 520                 525             


Asn Leu Leu Phe Gln Val Leu Ser Lys Leu Gly Val Lys Tyr Tyr Val 
    530                 535                 540                 


Leu Asp Tyr Arg Phe Asn Tyr Asp Tyr Ile Ile Gly Ile Asp Val Ala 
545                 550                 555                 560 


Pro Met Lys Arg Ser Glu Gly Tyr Ile Gly Gly Ser Ala Val Met Phe 
                565                 570                 575     


Asp Ser Gln Gly Tyr Ile Arg Lys Ile Val Pro Ile Lys Ile Gly Glu 
            580                 585                 590         


Gln Arg Gly Glu Ser Val Asp Met Asn Glu Phe Phe Lys Glu Met Val 
        595                 600                 605             


Asp Lys Phe Lys Glu Phe Asn Ile Lys Leu Asp Asn Lys Lys Ile Leu 
    610                 615                 620                 


Leu Leu Arg Asp Gly Arg Ile Thr Asn Asn Glu Glu Glu Gly Leu Lys 
625                 630                 635                 640 


Tyr Ile Ser Glu Met Phe Asp Ile Glu Val Val Thr Met Asp Val Ile 
                645                 650                 655     


Lys Asn His Pro Val Arg Ala Phe Ala Asn Met Lys Met Tyr Phe Asn 
            660                 665                 670         


Leu Gly Gly Ala Ile Tyr Leu Ile Pro His Lys Leu Lys Gln Ala Lys 
        675                 680                 685             


Gly Thr Pro Ile Pro Ile Lys Leu Ala Lys Lys Arg Ile Ile Lys Asn 
    690                 695                 700                 


Gly Lys Val Glu Lys Gln Ser Ile Thr Arg Gln Asp Val Leu Asp Ile 
705                 710                 715                 720 


Phe Ile Leu Thr Arg Leu Asn Tyr Gly Ser Ile Ser Ala Asp Met Arg 
                725                 730                 735     


Leu Pro Ala Pro Val His Tyr Ala His Lys Phe Ala Asn Ala Ile Arg 
            740                 745                 750         


Asn Glu Trp Lys Ile Lys Glu Glu Phe Leu Ala Glu Gly Phe Leu Tyr 
        755                 760                 765             


Phe Val 
    770 


<210> 122
<211> 427
<212> PRT
<213> Archaeoglobus fulgidus

<400> 122
Met Met Glu Tyr Lys Ile Val Glu Asn Gly Leu Thr Tyr Arg Ile Gly 
1               5                   10                  15      


Asn Gly Ala Ser Val Pro Ile Ser Asn Thr Gly Glu Leu Ile Lys Gly 
            20                  25                  30          


Leu Arg Asn Tyr Gly Pro Tyr Glu Val Pro Ser Leu Lys Tyr Asn Gln 
        35                  40                  45              


Ile Ala Leu Ile His Asn Asn Gln Phe Ser Ser Leu Ile Asn Gln Leu 
    50                  55                  60                  


Lys Ser Gln Ile Ser Ser Lys Ile Asp Glu Val Trp His Ile His Asn 
65                  70                  75                  80  


Ile Asn Ile Ser Glu Phe Ile Tyr Asp Ser Pro His Phe Asp Ser Ile 
                85                  90                  95      


Lys Ser Gln Val Asp Asn Ala Ile Asp Thr Gly Val Asp Gly Ile Met 
            100                 105                 110         


Leu Val Leu Pro Glu Tyr Asn Thr Pro Leu Tyr Tyr Lys Leu Lys Ser 
        115                 120                 125             


Tyr Leu Ile Asn Ser Ile Pro Ser Gln Phe Met Arg Tyr Asp Ile Leu 
    130                 135                 140                 


Ser Asn Arg Asn Leu Thr Phe Tyr Val Asp Asn Leu Leu Val Gln Phe 
145                 150                 155                 160 


Val Ser Lys Leu Gly Gly Lys Pro Trp Ile Leu Asn Val Asp Pro Glu 
                165                 170                 175     


Lys Gly Ser Asp Ile Ile Ile Gly Thr Gly Ala Thr Arg Ile Asp Asn 
            180                 185                 190         


Val Asn Leu Phe Cys Phe Ala Met Val Phe Lys Lys Asp Gly Thr Met 
        195                 200                 205             


Leu Trp Asn Glu Ile Ser Pro Ile Val Thr Ser Ser Glu Tyr Leu Thr 
    210                 215                 220                 


Tyr Leu Lys Ser Thr Ile Lys Lys Val Val Tyr Gly Phe Lys Lys Ser 
225                 230                 235                 240 


Asn Pro Asp Trp Asp Val Glu Lys Leu Thr Leu His Val Ser Gly Lys 
                245                 250                 255     


Arg Pro Lys Met Lys Asp Gly Glu Thr Lys Ile Leu Lys Glu Thr Val 
            260                 265                 270         


Glu Glu Leu Lys Lys Gln Glu Met Val Ser Arg Asp Val Lys Tyr Ala 
        275                 280                 285             


Ile Leu His Leu Asn Glu Thr His Pro Phe Trp Val Met Gly Asp Pro 
    290                 295                 300                 


Asn Asn Arg Phe His Pro Tyr Glu Gly Thr Lys Val Lys Leu Ser Ser 
305                 310                 315                 320 


Lys Arg Tyr Leu Leu Thr Leu Leu Gln Pro Tyr Leu Lys Arg Asn Gly 
                325                 330                 335     


Leu Glu Met Val Thr Pro Ile Lys Pro Leu Ser Val Glu Ile Val Ser 
            340                 345                 350         


Asp Asn Trp Thr Ser Glu Glu Tyr Tyr His Asn Val His Glu Ile Leu 
        355                 360                 365             


Asp Glu Ile Tyr Tyr Leu Ser Lys Met Asn Trp Arg Gly Phe Arg Ser 
    370                 375                 380                 


Arg Asn Leu Pro Val Thr Val Asn Tyr Pro Lys Leu Val Ala Gly Ile 
385                 390                 395                 400 


Ile Ala Asn Val Asn Arg Tyr Gly Gly Tyr Pro Ile Asn Pro Glu Gly 
                405                 410                 415     


Asn Arg Ser Leu Gln Thr Asn Pro Trp Phe Leu 
            420                 425         


<210> 123
<211> 707
<212> PRT
<213> Anoxybacillus flavithermus

<400> 123
Met Asn Gln Tyr Tyr Ile Thr Glu Cys Met Ala Asn Glu Asn Ala Asn 
1               5                   10                  15      


Asn Ile Pro Leu His Ile Tyr Thr Val Ser Leu Leu Asn Pro Asn Gln 
            20                  25                  30          


Lys Tyr Ser Phe Ala His His Ile Val Tyr Glu Leu Arg Lys Arg Asn 
        35                  40                  45              


Pro Asn Val Thr Ile Ala Val His Gly Gln Tyr Ile Ala Ser Phe Gln 
    50                  55                  60                  


Glu Ile Ala His Trp Gly Asp His Glu Tyr Ile Lys His Glu Tyr Arg 
65                  70                  75                  80  


Ala Ile Glu Cys Phe Asn Ala Thr Glu Arg Thr Val Leu Glu Arg Leu 
                85                  90                  95      


Leu Lys Gln Glu Leu Ile Glu Arg Cys Lys Ser Asp Tyr Lys Ile Tyr 
            100                 105                 110         


Lys Asp Leu Phe Cys Leu Lys Thr Glu Gln Ser Ile Glu Met Asn Glu 
        115                 120                 125             


Ile Ile Val Tyr Pro Ala Ile Tyr Leu Ser Phe Thr Val Glu Glu Asn 
    130                 135                 140                 


Gly Asn Ile Leu Ile Gly Phe Glu Tyr Gln His Arg Phe Glu Tyr Lys 
145                 150                 155                 160 


Lys Thr Leu Glu Asp Leu Leu Arg Asp Arg Ser Pro Leu Ile Lys Glu 
                165                 170                 175     


Gly Val Glu Val Val Asp Ser Tyr Asn Lys Lys Ser Tyr Tyr Tyr Thr 
            180                 185                 190         


Phe Val Glu Val Ala Pro Tyr Thr Ala Gly Glu Lys Ser Pro Tyr Leu 
        195                 200                 205             


Gln Gln Ser Val Ile Asp Tyr Tyr Ile Thr Lys Asn Glu Lys Trp Lys 
    210                 215                 220                 


Leu Lys Gly Val His Asn Lys Thr Pro Ile Val His Val Arg Ser Gln 
225                 230                 235                 240 


Thr Gly Asp Ile Phe Pro Tyr Leu Pro His Leu Leu Arg Leu Thr Cys 
                245                 250                 255     


Ser Tyr Glu Gln Leu Met Pro Ser Thr Ala Lys Gln Val Asn Arg Ile 
            260                 265                 270         


Ile Lys Leu Pro Pro Asn Lys Lys Met Pro Lys Leu Tyr Gln Glu Ile 
        275                 280                 285             


Phe Arg Leu Leu Gln Tyr Gln Asp Met Leu Thr Phe Arg Lys Glu Asn 
    290                 295                 300                 


Val Arg Ala Ala Asn Leu Asn Tyr Asn Ile Phe Lys Leu Ser Pro Pro 
305                 310                 315                 320 


Leu Met Lys Phe Gly Arg Asn Tyr Thr Thr Thr Lys Val Ser Asp Gly 
                325                 330                 335     


Leu Gly Gln Ala Gly Val Tyr Glu Pro Lys Ser Val Thr Val Ser Tyr 
            340                 345                 350         


Phe Val Asp Pro Glu Leu Asn Tyr Asp Gln Arg Lys Lys Asp Glu Ile 
        355                 360                 365             


Leu Asp Phe Thr Lys Lys Leu Gln Asp Leu Ser Gly Lys Leu Gly Val 
    370                 375                 380                 


Lys Leu Asn Val Ser Lys Lys Pro Arg Gln Leu Phe Gly Val Leu Pro 
385                 390                 395                 400 


Val Asp Phe Phe Lys Ser Glu Arg Leu Ser Phe Glu Leu Lys Ser Ile 
                405                 410                 415     


Thr Asn Ala Phe Glu Gly Thr Ile Val Val Ile Gly Thr Glu Glu Asn 
            420                 425                 430         


Ile Glu Arg Ala Tyr Met Ala Ile Lys Lys Glu Phe Gly Ala Lys Ala 
        435                 440                 445             


Asp Ile Met Thr Gln Phe Val Ile Phe Asp Ser Ser Ile Val Asn Asn 
    450                 455                 460                 


Ser Phe Tyr Tyr Tyr Asn Val Leu Leu Gly Ile Tyr Ala Lys Ser Gly 
465                 470                 475                 480 


Val Gln Pro Trp Ile Leu Leu Asp His Met Asn Ser Asp Cys Phe Ile 
                485                 490                 495     


Gly Leu Asp Val Ser His Glu Gln Gly Lys His Ala Ser Gly Ile Ile 
            500                 505                 510         


Gln Val Ile Gly Lys Asp Gly Arg Ile Ile Lys Gln Lys Ser Val Met 
        515                 520                 525             


Ala Thr Glu Ala Gly Glu Thr Ile Ala Arg Cys Thr Met Glu Glu Ile 
    530                 535                 540                 


Ile Asn Glu Ser Ile Phe Ser Tyr Glu Lys Met Tyr Gly Met Lys Pro 
545                 550                 555                 560 


Ser His Ile Thr Phe His Arg Asp Gly Val Cys Arg Glu Asp Leu Ala 
                565                 570                 575     


His Leu Thr Gln Tyr Met Gln Ser Phe Gln Ile Pro Phe Asp Phe Val 
            580                 585                 590         


Glu Ile Ile Lys Lys Pro Arg Arg Arg Met Ala Val Tyr Lys Asn Lys 
        595                 600                 605             


Ser Trp Phe Thr Glu Gln Gly Leu Cys Tyr Ala Lys Glu Arg Met Ala 
    610                 615                 620                 


Tyr Leu Cys Ala Thr Asp Pro Arg Glu Ser Val Gly Met Ala Gln Val 
625                 630                 635                 640 


Val Lys Ile Val Gln Lys Thr Asn Cys Leu Ser Ile Arg Asp Ile Val 
                645                 650                 655     


Ser Asp Ala Tyr Lys Leu Ser Phe Met His Ile His Ser Met Leu Lys 
            660                 665                 670         


Thr Arg Leu Pro Ile Thr Ile His Tyr Ala Asp Leu Ser Ser Thr Phe 
        675                 680                 685             


His Asn Arg Gly Leu Ile His Pro Arg Ser Val His Glu Arg Ala Leu 
    690                 695                 700                 


Pro Phe Val 
705         


<210> 124
<211> 895
<212> PRT
<213> Halogeometricum borinquense

<400> 124
Met Ala Val Lys Ala Asp Ile Glu Asp Gly Glu Glu Ile Asp Ile Ala 
1               5                   10                  15      


Leu His Val Thr Gly Ile Asp Glu Trp Glu His Asp Ala Ile Ala Arg 
            20                  25                  30          


Lys Ile Gln Leu Glu Asp Val Asp Gly Ala Ala Ile Asp Leu Thr Val 
        35                  40                  45              


Phe His Asn Asn Asp Val Ser Asp Phe Glu Trp Glu Ile Gly Glu Trp 
    50                  55                  60                  


Tyr Leu Leu Glu Asn Val Val Gly Asn Glu Phe Arg Gly Glu Met Gln 
65                  70                  75                  80  


Leu Asn Pro Gly Tyr Asp Leu Thr Val Thr Leu Leu Asn Asp Pro Pro 
                85                  90                  95      


Ala Ala Ala Gly Asn Asp Lys Ser Pro Gly Ser Val Pro Pro Glu Glu 
            100                 105                 110         


Pro Val Asp Gln Ser Gly Glu Ser Gly Ser Ser Gly Ala Ala Ala Ser 
        115                 120                 125             


Thr Ser Gly Glu Pro Gly Asp Ala Glu Phe Val Arg Gly Ser Glu Val 
    130                 135                 140                 


Asp Asp Gly Ser Arg Pro Thr Ala Asp Gly Gly Gly Lys Leu Leu His 
145                 150                 155                 160 


Gln Gln Pro Leu Ser Asp Gly Asn Tyr Leu Leu Gln Phe Glu Leu Gly 
                165                 170                 175     


Ser Leu Pro Glu Leu Pro Val His Glu Tyr Glu Leu Arg Ala Thr Gly 
            180                 185                 190         


Ser Gly Gly Ile Asp Pro Asp Asp Phe Thr Asn Gly Ile Glu Gly Phe 
        195                 200                 205             


Thr Ala Lys Ala Ala Asn Tyr Tyr Gln Ser Arg Ile Gly Ser Pro Val 
    210                 215                 220                 


Thr Thr Ala Asp Ala Ser Arg Arg Arg Ile Tyr Ala Thr Glu Lys Leu 
225                 230                 235                 240 


His Gly Thr Ile Ser Met His Gly Tyr Thr Val Lys Pro Val His Gln 
                245                 250                 255     


Gly Glu Thr Thr Leu Glu Ala Arg Ser Tyr Thr Asn Asp Gly Pro Leu 
            260                 265                 270         


Gln Glu Phe Val Lys Gln Asp Val Lys Arg Ala Val Ala Gly Arg Phe 
        275                 280                 285             


Glu Val Ser Gly Ile Asp Ser Ile Ile Glu Pro Thr Pro Gln Arg Thr 
    290                 295                 300                 


Ala Asn Ser Gly Leu Phe Glu Ala Tyr Arg Lys Tyr Lys Cys Arg Ile 
305                 310                 315                 320 


Arg Val Asp Ala Asp Gly Thr Val Ile Cys Gly Val Asn Val Ala Tyr 
                325                 330                 335     


His Leu Glu Ser Thr Phe Ser Ala Ala Glu Trp Val Gln Arg Gly His 
            340                 345                 350         


Asp Ile Ala Asp Val Thr Val Glu His Asp Thr Asp Leu Tyr Asp Ser 
        355                 360                 365             


Ala Arg Thr Ala Thr Val Lys Glu Ile Ile Asp Met Asp Tyr Asp Asp 
    370                 375                 380                 


Met Leu Asp Gly Pro Gly Val Pro Met Ser Glu Tyr His Glu Lys His 
385                 390                 395                 400 


Val Glu Gln Asp Val Ile Asp Ser Met Arg Ala Gly Asn Pro Val Ile 
                405                 410                 415     


Ala Asp Leu Gln Tyr Gly Ser Gly Glu Asp Ser Ile Phe Pro Gln Leu 
            420                 425                 430         


Leu Glu Tyr Cys Lys Val Ile Pro Thr Phe Asp Gln Leu Gly Arg Val 
        435                 440                 445             


Asp Glu Thr Phe Leu Asn Val Ile His Asn Glu Ser Arg Met Lys Pro 
    450                 455                 460                 


Glu Glu Arg Phe Asn Val Val Thr Ser Phe Val Asp Leu Leu Gly Pro 
465                 470                 475                 480 


Thr Pro Tyr Phe Asp Phe Gly Pro Val Pro Gln Pro Thr Asn Ala Gly 
                485                 490                 495     


Tyr Arg Glu Gln Lys Thr Pro Asn Ile Pro Asn Leu Arg Phe Gly Asp 
            500                 505                 510         


Gly Arg Thr Gly Tyr Tyr Gly Ala Gly Gly Leu Glu Arg Lys Gly Tyr 
        515                 520                 525             


Gly Val Tyr Lys Ala Pro Glu Ser Phe Asp Ile Ile Ala Leu Tyr Pro 
    530                 535                 540                 


Asp Ser Glu Gln Ala Ala Ala Arg Pro Tyr Val Leu Ser Val Leu Gly 
545                 550                 555                 560 


Lys Leu Ala Glu Tyr Asp Gly Lys Pro Thr Lys Phe Asp Gln Glu Thr 
                565                 570                 575     


Tyr Glu Leu Gly Ser Glu Phe His Tyr Ser Gln His Ala Gln Lys Thr 
            580                 585                 590         


Ser Asp Tyr Asp Ala Ala Leu Ile Val Val Pro Asp Lys Asp Lys Ala 
        595                 600                 605             


Ala Ala Ala Asp Tyr Asp Asp Pro Tyr Pro Glu Phe Lys Arg Arg Leu 
    610                 615                 620                 


Gly Gln Leu Gly Val Pro Ser Gln Met Ile Thr Ile Asp Asn Leu Gly 
625                 630                 635                 640 


Asn Asp Ser Tyr Leu Gly Asn Ile Ser Ser Ser Leu Ile Gly Lys Ala 
                645                 650                 655     


Gly Gly Val Pro Trp Arg Ile Asp Asp Val Pro Gly Asp Val Asp Ala 
            660                 665                 670         


Phe Val Gly Leu Asp Val Thr Tyr Asp His Ala Thr Lys Gln His Leu 
        675                 680                 685             


Gly Ala Ala Ala Asn Val Ile Met Ala Asp Gly Thr Ile Leu Ala Ser 
    690                 695                 700                 


Glu Ala Val Thr Lys Gln Ala Gly Glu Thr Phe Asp Glu Asp Asp Val 
705                 710                 715                 720 


Ala Asn Val Ile Lys His Val Leu Glu Ile Phe Ala Glu Glu Glu Gly 
                725                 730                 735     


Arg Pro Pro Arg His Val Val Ile His Arg Asp Gly Lys Phe Tyr Leu 
            740                 745                 750         


Asp Ile Glu Ser Leu Ile Lys Arg Leu Asp Lys Ala Arg Asp Leu Ile 
        755                 760                 765             


Gln Arg Phe Asp Leu Val Glu Ile Arg Lys Ser Gly Asn Pro Arg Ile 
    770                 775                 780                 


Ala Glu Tyr Asp Glu Ser Lys Ser Arg Phe Asp Ile Ala Asp Lys Gly 
785                 790                 795                 800 


Val Ala Phe His Val His Asn Gly Asp His Ser Tyr Leu Thr Thr Thr 
                805                 810                 815     


Gly Gly Lys Glu Gly Ser Pro Gly Thr Pro Arg Pro Leu Gln Ile Val 
            820                 825                 830         


Lys Arg His Gly Ser Thr Asp Leu Asp Thr Leu Ala Glu Gln Thr Tyr 
        835                 840                 845             


Trp Leu Ser Glu Ala His Val Gly Ser Leu Ser Arg Ser Thr Arg Leu 
    850                 855                 860                 


Pro Ile Thr Thr Tyr Tyr Ala Asp Lys Cys Ala Asp Phe Ala Met Lys 
865                 870                 875                 880 


Gly Tyr Leu Thr Lys Gly Ser Val Ile Arg Gly Val Pro Tyr Ile 
                885                 890                 895 


<210> 125
<211> 735
<212> PRT
<213> Synococchus elongatus

<400> 125
Met Asp Leu Leu Ser Asn Leu Arg Arg Ser Ser Ile Val Leu Asn Arg 
1               5                   10                  15      


Phe Tyr Val Lys Ser Leu Ser Gln Ser Asp Leu Thr Ala Tyr Glu Tyr 
            20                  25                  30          


Arg Cys Ile Phe Lys Lys Thr Pro Glu Leu Gly Asp Glu Lys Arg Leu 
        35                  40                  45              


Leu Ala Ser Ile Cys Tyr Lys Leu Gly Ala Ile Ala Val Arg Ile Gly 
    50                  55                  60                  


Ser Asn Ile Ile Thr Lys Glu Ala Val Arg Pro Glu Lys Leu Gln Gly 
65                  70                  75                  80  


His Asp Trp Gln Leu Val Gln Met Gly Thr Lys Gln Leu Asp Cys Arg 
                85                  90                  95      


Asn Asp Ala His Arg Cys Ala Leu Glu Thr Phe Glu Arg Lys Phe Leu 
            100                 105                 110         


Glu Arg Asp Leu Ser Ala Ser Ser Gln Thr Glu Val Arg Lys Ala Ala 
        115                 120                 125             


Glu Gly Gly Leu Ile Trp Trp Val Val Gly Ala Lys Gly Ile Glu Lys 
    130                 135                 140                 


Ser Gly Asn Gly Trp Glu Val His Arg Gly Arg Arg Ile Asp Val Ser 
145                 150                 155                 160 


Leu Asp Ala Glu Gly Asn Leu Tyr Leu Glu Ile Asp Ile His His Arg 
                165                 170                 175     


Phe Tyr Thr Pro Trp Thr Val His Gln Trp Leu Glu Gln Tyr Pro Glu 
            180                 185                 190         


Ile Pro Leu Ser Tyr Val Arg Asn Asn Tyr Leu Asp Glu Arg His Gly 
        195                 200                 205             


Phe Ile Asn Trp Gln Tyr Gly Arg Phe Thr Gln Glu Arg Pro Gln Asp 
    210                 215                 220                 


Ile Leu Leu Asp Cys Leu Gly Met Ser Leu Ala Glu Tyr His Leu Asn 
225                 230                 235                 240 


Lys Gly Ala Thr Glu Glu Glu Val Gln Gln Ser Tyr Val Val Tyr Val 
                245                 250                 255     


Lys Pro Ile Ser Trp Arg Lys Gly Lys Leu Thr Ala His Leu Ser Arg 
            260                 265                 270         


Arg Leu Ser Pro Ser Leu Thr Met Glu Met Leu Ala Lys Val Ala Glu 
        275                 280                 285             


Asp Ser Thr Val Cys Asp Arg Glu Lys Arg Glu Ile Arg Ala Val Phe 
    290                 295                 300                 


Lys Ser Ile Lys Gln Ser Ile Asn Gln Arg Leu Gln Glu Ala Gln Lys 
305                 310                 315                 320 


Thr Ala Ser Trp Ile Leu Thr Lys Thr Tyr Gly Ile Ser Ser Pro Ala 
                325                 330                 335     


Ile Ala Leu Ser Cys Asp Gly Tyr Leu Leu Pro Ala Ala Lys Leu Leu 
            340                 345                 350         


Ala Ala Asn Lys Gln Pro Val Ser Lys Thr Ala Asp Ile Arg Asn Lys 
        355                 360                 365             


Gly Cys Ala Lys Ile Gly Glu Thr Ser Phe Gly Tyr Leu Asn Leu Tyr 
    370                 375                 380                 


Asn Asn Gln Leu Gln Tyr Pro Leu Glu Val His Lys Cys Leu Leu Glu 
385                 390                 395                 400 


Ile Ala Asn Lys Asn Asn Leu Gln Leu Ser Leu Asp Gln Arg Arg Val 
                405                 410                 415     


Leu Ser Asp Tyr Pro Gln Asp Asp Leu Asp Gln Gln Met Phe Trp Gln 
            420                 425                 430         


Thr Trp Ser Ser Gln Gly Ile Lys Thr Val Leu Val Val Met Pro Trp 
        435                 440                 445             


Asp Ser His His Asp Lys Gln Lys Ile Arg Ile Gln Ala Ile Gln Ala 
    450                 455                 460                 


Gly Ile Ala Thr Gln Phe Met Val Pro Leu Pro Lys Ala Asp Lys Tyr 
465                 470                 475                 480 


Lys Ala Leu Asn Val Thr Leu Gly Leu Leu Cys Lys Ala Gly Trp Gln 
                485                 490                 495     


Pro Ile Gln Leu Glu Ser Val Asp His Pro Glu Val Ala Asp Leu Ile 
            500                 505                 510         


Ile Gly Phe Asp Thr Gly Thr Asn Arg Glu Leu Tyr Tyr Gly Thr Ser 
        515                 520                 525             


Ala Phe Ala Val Leu Ala Asp Gly Gln Ser Leu Gly Trp Glu Leu Pro 
    530                 535                 540                 


Ala Val Gln Arg Gly Glu Thr Phe Ser Gly Gln Ala Ile Trp Gln Thr 
545                 550                 555                 560 


Val Ser Lys Leu Ile Ile Lys Phe Tyr Gln Ile Cys Gln Arg Tyr Pro 
                565                 570                 575     


Gln Lys Leu Leu Leu Met Arg Asp Gly Leu Val Gln Glu Gly Glu Phe 
            580                 585                 590         


Gln Gln Thr Ile Glu Leu Leu Lys Glu Arg Lys Ile Ala Val Asp Val 
        595                 600                 605             


Ile Ser Val Arg Lys Ser Gly Ala Gly Arg Met Gly Gln Glu Ile Tyr 
    610                 615                 620                 


Glu Asn Gly Gln Leu Val Tyr Arg Asp Ala Ala Ile Gly Ser Val Ile 
625                 630                 635                 640 


Leu Gln Pro Ala Glu Arg Ser Phe Ile Met Val Thr Ser Gln Pro Val 
                645                 650                 655     


Ser Lys Thr Ile Gly Ser Ile Arg Pro Leu Arg Ile Val His Glu Tyr 
            660                 665                 670         


Gly Ser Thr Asp Leu Glu Leu Leu Ala Leu Gln Thr Tyr His Leu Thr 
        675                 680                 685             


Gln Leu His Pro Ala Ser Gly Phe Arg Ser Cys Arg Leu Pro Trp Val 
    690                 695                 700                 


Leu His Leu Ala Asp Arg Ser Ser Lys Glu Phe Gln Arg Ile Gly Gln 
705                 710                 715                 720 


Ile Ser Val Leu Gln Asn Ile Ser Arg Asp Lys Leu Ile Ala Val 
                725                 730                 735 


