                         SEQUENCE LISTING

<110>  IBB
 
<120>  Method for selection of hDIS3 PIN domain inhibitors and use of 
       hDIS3 PIN domain inhibitors for cancer treatment

<130>  PZ/1970/AGR/PCT

<160>  98    

<170>  PatentIn version 3.5

<210>  1
<211>  958
<212>  PRT
<213>  Homo sapiens

<400>  1

Met Leu Lys Ser Lys Thr Phe Leu Lys Lys Thr Arg Ala Gly Gly Val 
1               5                   10                  15      


Met Lys Ile Val Arg Glu His Tyr Leu Arg Asp Asp Ile Gly Cys Gly 
            20                  25                  30          


Ala Pro Gly Cys Ala Ala Cys Gly Gly Ala His Glu Gly Pro Ala Leu 
        35                  40                  45              


Glu Pro Gln Pro Gln Asp Pro Ala Ser Ser Val Cys Pro Gln Pro His 
    50                  55                  60                  


Tyr Leu Leu Pro Asp Thr Asn Val Leu Leu His Gln Ile Asp Val Leu 
65                  70                  75                  80  


Glu Asp Pro Ala Ile Arg Asn Val Ile Val Leu Gln Thr Val Leu Gln 
                85                  90                  95      


Glu Val Arg Asn Arg Ser Ala Pro Val Tyr Lys Arg Ile Arg Asp Val 
            100                 105                 110         


Thr Asn Asn Gln Glu Lys His Phe Tyr Thr Phe Thr Asn Glu His His 
        115                 120                 125             


Arg Glu Thr Tyr Val Glu Gln Glu Gln Gly Glu Asn Ala Asn Asp Arg 
    130                 135                 140                 


Asn Asp Arg Ala Ile Arg Val Ala Ala Lys Trp Tyr Asn Glu His Leu 
145                 150                 155                 160 


Lys Lys Met Ser Ala Asp Asn Gln Leu Gln Val Ile Phe Ile Thr Asn 
                165                 170                 175     


Asp Arg Arg Asn Lys Glu Lys Ala Ile Glu Glu Gly Ile Pro Ala Phe 
            180                 185                 190         


Thr Cys Glu Glu Tyr Val Lys Ser Leu Thr Ala Asn Pro Glu Leu Ile 
        195                 200                 205             


Asp Arg Leu Ala Cys Leu Ser Glu Glu Gly Asn Glu Ile Glu Ser Gly 
    210                 215                 220                 


Lys Ile Ile Phe Ser Glu His Leu Pro Leu Ser Lys Leu Gln Gln Gly 
225                 230                 235                 240 


Ile Lys Ser Gly Thr Tyr Leu Gln Gly Thr Phe Arg Ala Ser Arg Glu 
                245                 250                 255     


Asn Tyr Leu Glu Ala Thr Val Trp Ile His Gly Asp Ser Glu Glu Asn 
            260                 265                 270         


Lys Glu Ile Ile Leu Gln Gly Leu Lys His Leu Asn Arg Ala Val His 
        275                 280                 285             


Glu Asp Ile Val Ala Val Glu Leu Leu Pro Lys Ser Gln Trp Val Ala 
    290                 295                 300                 


Pro Ser Ser Val Val Leu His Asp Glu Gly Gln Asn Glu Glu Asp Val 
305                 310                 315                 320 


Glu Lys Glu Glu Glu Thr Glu Arg Met Leu Lys Thr Ala Val Ser Glu 
                325                 330                 335     


Lys Met Leu Lys Pro Thr Gly Arg Val Val Gly Ile Ile Lys Arg Asn 
            340                 345                 350         


Trp Arg Pro Tyr Cys Gly Met Leu Ser Lys Ser Asp Ile Lys Glu Ser 
        355                 360                 365             


Arg Arg His Leu Phe Thr Pro Ala Asp Lys Arg Ile Pro Arg Ile Arg 
    370                 375                 380                 


Ile Glu Thr Arg Gln Ala Ser Thr Leu Glu Gly Arg Arg Ile Ile Val 
385                 390                 395                 400 


Ala Ile Asp Gly Trp Pro Arg Asn Ser Arg Tyr Pro Asn Gly His Phe 
                405                 410                 415     


Val Arg Asn Leu Gly Asp Val Gly Glu Lys Glu Thr Glu Thr Glu Val 
            420                 425                 430         


Leu Leu Leu Glu His Asp Val Pro His Gln Pro Phe Ser Gln Ala Val 
        435                 440                 445             


Leu Ser Phe Leu Pro Lys Met Pro Trp Ser Ile Thr Glu Lys Asp Met 
    450                 455                 460                 


Lys Asn Arg Glu Asp Leu Arg His Leu Cys Ile Cys Ser Val Asp Pro 
465                 470                 475                 480 


Pro Gly Cys Thr Asp Ile Asp Asp Ala Leu His Cys Arg Glu Leu Glu 
                485                 490                 495     


Asn Gly Asn Leu Glu Val Gly Val His Ile Ala Asp Val Ser His Phe 
            500                 505                 510         


Ile Arg Pro Gly Asn Ala Leu Asp Gln Glu Ser Ala Arg Arg Gly Thr 
        515                 520                 525             


Thr Val Tyr Leu Cys Glu Lys Arg Ile Asp Met Val Pro Glu Leu Leu 
    530                 535                 540                 


Ser Ser Asn Leu Cys Ser Leu Lys Cys Asp Val Asp Arg Leu Ala Phe 
545                 550                 555                 560 


Ser Cys Ile Trp Glu Met Asn His Asn Ala Glu Ile Leu Lys Thr Lys 
                565                 570                 575     


Phe Thr Lys Ser Val Ile Asn Ser Lys Ala Ser Leu Thr Tyr Ala Glu 
            580                 585                 590         


Ala Gln Leu Arg Ile Asp Ser Ala Asn Met Asn Asp Asp Ile Thr Thr 
        595                 600                 605             


Ser Leu Arg Gly Leu Asn Lys Leu Ala Lys Ile Leu Lys Lys Arg Arg 
    610                 615                 620                 


Ile Glu Lys Gly Ala Leu Thr Leu Ser Ser Pro Glu Val Arg Phe His 
625                 630                 635                 640 


Met Asp Ser Glu Thr His Asp Pro Ile Asp Leu Gln Thr Lys Glu Leu 
                645                 650                 655     


Arg Glu Thr Asn Ser Met Val Glu Glu Phe Met Leu Leu Ala Asn Ile 
            660                 665                 670         


Ser Val Ala Lys Lys Ile His Glu Glu Phe Ser Glu His Ala Leu Leu 
        675                 680                 685             


Arg Lys His Pro Ala Pro Pro Pro Ser Asn Tyr Glu Ile Leu Val Lys 
    690                 695                 700                 


Ala Ala Arg Ser Arg Asn Leu Glu Ile Lys Thr Asp Thr Ala Lys Ser 
705                 710                 715                 720 


Leu Ala Glu Ser Leu Asp Gln Ala Glu Ser Pro Thr Phe Pro Tyr Leu 
                725                 730                 735     


Asn Thr Leu Leu Arg Ile Leu Ala Thr Arg Cys Met Met Gln Ala Val 
            740                 745                 750         


Tyr Phe Cys Ser Gly Met Asp Asn Asp Phe His His Tyr Gly Leu Ala 
        755                 760                 765             


Ser Pro Ile Tyr Thr His Phe Thr Ser Pro Ile Arg Arg Tyr Ala Asp 
    770                 775                 780                 


Val Ile Val His Arg Leu Leu Ala Val Ala Ile Gly Ala Asp Cys Thr 
785                 790                 795                 800 


Tyr Pro Glu Leu Thr Asp Lys His Lys Leu Ala Asp Ile Cys Lys Asn 
                805                 810                 815     


Leu Asn Phe Arg His Lys Met Ala Gln Tyr Ala Gln Arg Ala Ser Val 
            820                 825                 830         


Ala Phe His Thr Gln Leu Phe Phe Lys Ser Lys Gly Ile Val Ser Glu 
        835                 840                 845             


Glu Ala Tyr Ile Leu Phe Val Arg Lys Asn Ala Ile Val Val Leu Ile 
    850                 855                 860                 


Pro Lys Tyr Gly Leu Glu Gly Thr Val Phe Phe Glu Glu Lys Asp Lys 
865                 870                 875                 880 


Pro Asn Pro Gln Leu Ile Tyr Asp Asp Glu Ile Pro Ser Leu Lys Ile 
                885                 890                 895     


Glu Asp Thr Val Phe His Val Phe Asp Lys Val Lys Val Lys Ile Met 
            900                 905                 910         


Leu Asp Ser Ser Asn Leu Gln His Gln Lys Ile Arg Met Ser Leu Val 
        915                 920                 925             


Glu Pro Gln Ile Pro Gly Ile Ser Ile Pro Thr Asp Thr Ser Asn Met 
    930                 935                 940                 


Asp Leu Asn Gly Pro Lys Lys Lys Lys Met Lys Leu Gly Lys 
945                 950                 955             


<210>  2
<211>  1001
<212>  PRT
<213>  Saccharomyces cerevisiae

<400>  2

Met Ser Val Pro Ala Ile Ala Pro Arg Arg Lys Arg Leu Ala Asp Gly 
1               5                   10                  15      


Leu Ser Val Thr Gln Lys Val Phe Val Arg Ser Arg Asn Gly Gly Ala 
            20                  25                  30          


Thr Lys Ile Val Arg Glu His Tyr Leu Arg Ser Asp Ile Pro Cys Leu 
        35                  40                  45              


Ser Arg Ser Cys Thr Lys Cys Pro Gln Ile Val Val Pro Asp Ala Gln 
    50                  55                  60                  


Asn Glu Leu Pro Lys Phe Ile Leu Ser Asp Ser Pro Leu Glu Leu Ser 
65                  70                  75                  80  


Ala Pro Ile Gly Lys His Tyr Val Val Leu Asp Thr Asn Val Val Leu 
                85                  90                  95      


Gln Ala Ile Asp Leu Leu Glu Asn Pro Asn Cys Phe Phe Asp Val Ile 
            100                 105                 110         


Val Pro Gln Ile Val Leu Asp Glu Val Arg Asn Lys Ser Tyr Pro Val 
        115                 120                 125             


Tyr Thr Arg Leu Arg Thr Leu Cys Arg Asp Ser Asp Asp His Lys Arg 
    130                 135                 140                 


Phe Ile Val Phe His Asn Glu Phe Ser Glu His Thr Phe Val Glu Arg 
145                 150                 155                 160 


Leu Pro Asn Glu Thr Ile Asn Asp Arg Asn Asp Arg Ala Ile Arg Lys 
                165                 170                 175     


Thr Cys Gln Trp Tyr Ser Glu His Leu Lys Pro Tyr Asp Ile Asn Val 
            180                 185                 190         


Val Leu Val Thr Asn Asp Arg Leu Asn Arg Glu Ala Ala Thr Lys Glu 
        195                 200                 205             


Val Glu Ser Asn Ile Ile Thr Lys Ser Leu Val Gln Tyr Ile Glu Leu 
    210                 215                 220                 


Leu Pro Asn Ala Asp Asp Ile Arg Asp Ser Ile Pro Gln Met Asp Ser 
225                 230                 235                 240 


Phe Asp Lys Asp Leu Glu Arg Asp Thr Phe Ser Asp Phe Thr Phe Pro 
                245                 250                 255     


Glu Tyr Tyr Ser Thr Ala Arg Val Met Gly Gly Leu Lys Asn Gly Val 
            260                 265                 270         


Leu Tyr Gln Gly Asn Ile Gln Ile Ser Glu Tyr Asn Phe Leu Glu Gly 
        275                 280                 285             


Ser Val Ser Leu Pro Arg Phe Ser Lys Pro Val Leu Ile Val Gly Gln 
    290                 295                 300                 


Lys Asn Leu Asn Arg Ala Phe Asn Gly Asp Gln Val Ile Val Glu Leu 
305                 310                 315                 320 


Leu Pro Gln Ser Glu Trp Lys Ala Pro Ser Ser Ile Val Leu Asp Ser 
                325                 330                 335     


Glu His Phe Asp Val Asn Asp Asn Pro Asp Ile Glu Ala Gly Asp Asp 
            340                 345                 350         


Asp Asp Asn Asn Glu Ser Ser Ser Asn Thr Thr Val Ile Ser Asp Lys 
        355                 360                 365             


Gln Arg Arg Leu Leu Ala Lys Asp Ala Met Ile Ala Gln Arg Ser Lys 
    370                 375                 380                 


Lys Ile Gln Pro Thr Ala Lys Val Val Tyr Ile Gln Arg Arg Ser Trp 
385                 390                 395                 400 


Arg Gln Tyr Val Gly Gln Leu Ala Pro Ser Ser Val Asp Pro Gln Ser 
                405                 410                 415     


Ser Ser Thr Gln Asn Val Phe Val Ile Leu Met Asp Lys Cys Leu Pro 
            420                 425                 430         


Lys Val Arg Ile Arg Thr Arg Arg Ala Ala Glu Leu Leu Asp Lys Arg 
        435                 440                 445             


Ile Val Ile Ser Ile Asp Ser Trp Pro Thr Thr His Lys Tyr Pro Leu 
    450                 455                 460                 


Gly His Phe Val Arg Asp Leu Gly Thr Ile Glu Ser Ala Gln Ala Glu 
465                 470                 475                 480 


Thr Glu Ala Leu Leu Leu Glu His Asp Val Glu Tyr Arg Pro Phe Ser 
                485                 490                 495     


Lys Lys Val Leu Glu Cys Leu Pro Ala Glu Gly His Asp Trp Lys Ala 
            500                 505                 510         


Pro Thr Lys Leu Asp Asp Pro Glu Ala Val Ser Lys Asp Pro Leu Leu 
        515                 520                 525             


Thr Lys Arg Lys Asp Leu Arg Asp Lys Leu Ile Cys Ser Ile Asp Pro 
    530                 535                 540                 


Pro Gly Cys Val Asp Ile Asp Asp Ala Leu His Ala Lys Lys Leu Pro 
545                 550                 555                 560 


Asn Gly Asn Trp Glu Val Gly Val His Ile Ala Asp Val Thr His Phe 
                565                 570                 575     


Val Lys Pro Gly Thr Ala Leu Asp Ala Glu Gly Ala Ala Arg Gly Thr 
            580                 585                 590         


Ser Val Tyr Leu Val Asp Lys Arg Ile Asp Met Leu Pro Met Leu Leu 
        595                 600                 605             


Gly Thr Asp Leu Cys Ser Leu Lys Pro Tyr Val Asp Arg Phe Ala Phe 
    610                 615                 620                 


Ser Val Ile Trp Glu Leu Asp Asp Ser Ala Asn Ile Val Asn Val Asn 
625                 630                 635                 640 


Phe Met Lys Ser Val Ile Arg Ser Arg Glu Ala Phe Ser Tyr Glu Gln 
                645                 650                 655     


Ala Gln Leu Arg Ile Asp Asp Lys Thr Gln Asn Asp Glu Leu Thr Met 
            660                 665                 670         


Gly Met Arg Ala Leu Leu Lys Leu Ser Val Lys Leu Lys Gln Lys Arg 
        675                 680                 685             


Leu Glu Ala Gly Ala Leu Asn Leu Ala Ser Pro Glu Val Lys Val His 
    690                 695                 700                 


Met Asp Ser Glu Thr Ser Asp Pro Asn Glu Val Glu Ile Lys Lys Leu 
705                 710                 715                 720 


Leu Ala Thr Asn Ser Leu Val Glu Glu Phe Met Leu Leu Ala Asn Ile 
                725                 730                 735     


Ser Val Ala Arg Lys Ile Tyr Asp Ala Phe Pro Gln Thr Ala Met Leu 
            740                 745                 750         


Arg Arg His Ala Ala Pro Pro Ser Thr Asn Phe Glu Ile Leu Asn Glu 
        755                 760                 765             


Met Leu Asn Thr Arg Lys Asn Met Ser Ile Ser Leu Glu Ser Ser Lys 
    770                 775                 780                 


Ala Leu Ala Asp Ser Leu Asp Arg Cys Val Asp Pro Glu Asp Pro Tyr 
785                 790                 795                 800 


Phe Asn Thr Leu Val Arg Ile Met Ser Thr Arg Cys Met Met Ala Ala 
                805                 810                 815     


Gln Tyr Phe Tyr Ser Gly Ala Tyr Ser Tyr Pro Asp Phe Arg His Tyr 
            820                 825                 830         


Gly Leu Ala Val Asp Ile Tyr Thr His Phe Thr Ser Pro Ile Arg Arg 
        835                 840                 845             


Tyr Cys Asp Val Val Ala His Arg Gln Leu Ala Gly Ala Ile Gly Tyr 
    850                 855                 860                 


Glu Pro Leu Ser Leu Thr His Arg Asp Lys Asn Lys Met Asp Met Ile 
865                 870                 875                 880 


Cys Arg Asn Ile Asn Arg Lys His Arg Asn Ala Gln Phe Ala Gly Arg 
                885                 890                 895     


Ala Ser Ile Glu Tyr Tyr Val Gly Gln Val Met Arg Asn Asn Glu Ser 
            900                 905                 910         


Thr Glu Thr Gly Tyr Val Ile Lys Val Phe Asn Asn Gly Ile Val Val 
        915                 920                 925             


Leu Val Pro Lys Phe Gly Val Glu Gly Leu Ile Arg Leu Asp Asn Leu 
    930                 935                 940                 


Thr Glu Asp Pro Asn Ser Ala Ala Phe Asp Glu Val Glu Tyr Lys Leu 
945                 950                 955                 960 


Thr Phe Val Pro Thr Asn Ser Asp Lys Pro Arg Asp Val Tyr Val Phe 
                965                 970                 975     


Asp Lys Val Glu Val Gln Val Arg Ser Val Met Asp Pro Ile Thr Ser 
            980                 985                 990         


Lys Arg Lys Ala Glu Leu Leu Leu  Lys 
        995                 1000     


<210>  3
<211>  23
<212>  DNA
<213>  artificial

<220>
<223>  primer ADZKD106

<400>  3
cggtcatatg agagtgtgtt gcg                                               23


<210>  4
<211>  25
<212>  DNA
<213>  artificial

<220>
<223>   primer  ADZKD110

<400>  4
gagaatttgt attttcaggg tgagc                                             25


<210>  5
<211>  25
<212>  DNA
<213>  artificial

<220>
<223>  primer  ADZKD111

<400>  5
gctcaccctg aaaatacaaa ttctc                                             25


<210>  6
<211>  50
<212>  DNA
<213>  artificial

<220>
<223>  primer ADZKD107

<400>  6
agtggtttag tggtaaaatc caacgttgcc atcgttgggc ccccggttcg                  50


<210>  7
<211>  42
<212>  DNA
<213>  artificial

<220>
<223>  primer S477Rfor

<400>  7
tgtgtatctg cagagtagac ccaccaggat gtactgatat ag                          42


<210>  8
<211>  41
<212>  DNA
<213>  artificial

<220>
<223>  primer S477Rrev

<400>  8
ggtctactct gcagatacac agatgcctca ggtcttctcg g                           41


<210>  9
<211>  41
<212>  DNA
<213>  artificial

<220>
<223>  primer V504Gfo

<400>  9
aggttggtgg ccatattgct gatgtgagcc attttattag g                           41


<210>  10
<211>  42
<212>  DNA
<213>  artificial

<220>
<223>  primer cV504Grev

<400>  10
agcaatatgg ccaccaacct ccaaatttcc attttcgagt tc                          42


<210>  11
<211>  43
<212>  DNA
<213>  artificial

<220>
<223>  primer A524Pfor

<400>  11
agaatcacct aggagaggaa caactgtgta tctttgtgaa aag                         43


<210>  12
<211>  41
<212>  DNA
<213>  artificial

<220>
<223>  primer A524Prev

<400>  12
ttcctctcct aggtgattct tgatccaagg catttcctgg c                           41


<210>  13
<211>  41
<212>  DNA
<213>  artificial

<220>
<223>  primer G766Rfor

<400>  13
catcactacc ggttagcgtc tccaatatac acacatttta c                           41


<210>  14
<211>  43
<212>  DNA
<213>  artificial

<220>
<223>  primer G766Rrev

<400>  14
gacgctaacc ggtagtgatg aaaatcatta tccattccag aac                         43


<210>  15
<211>  43
<212>  DNA
<213>  artificial

<220>
<223>  primer R780Kfor

<400>  15
cccattaaac gttacgcaga tgtcattgtt catcggcttt tgg                         43


<210>  16
<211>  44
<212>  DNA
<213>  artificial

<220>
<223>  primer R780Krev

<400>  16
tctgcgtaac gtttaatggg tgaagtaaaa tgtgtgtata ttgg                        44


<210>  17
<211>  52
<212>  DNA
<213>  artificial

<220>
<223>  primer I845Vfor

<400>  17
caaaggagta gtaagtgaag aggcctatat tttatttgta agaaagaatg cc               52


<210>  18
<211>  52
<212>  DNA
<213>  artificial

<220>
<223>  primer I845Vrev

<400>  18
aaaatatagg cctcttcact tactactcct ttgcttttga agaataactg gg               52


<210>  19
<211>  20
<212>  DNA
<213>  artificial

<220>
<223>  primer SumoF

<400>  19
tcatactgtc aaagacaggg                                                   20


<210>  20
<211>  22
<212>  DNA
<213>  artificial

<220>
<223>  primer HD3F883

<400>  20
gaagatattg tggctgtgga gc                                                22


<210>  21
<211>  22
<212>  DNA
<213>  artificial

<220>
<223>  primer HD3F1848

<400>  21
ccgtggactg aataaactag cc                                                22


<210>  22
<211>  22
<212>  DNA
<213>  artificial

<220>
<223>  primer HD3F2429

<400>  22
tgacagacaa acacaagctt gc                                                22


<210>  23
<211>  22
<212>  DNA
<213>  artificial

<220>
<223>  primer HD3R1021

<400>  23
ttacagcagt cttaagcatt cg                                                22


<210>  24
<211>  22
<212>  DNA
<213>  artificial

<220>
<223>  primer HD3R1592

<400>  24
ctggctgatt cttgatccaa gg                                                22


<210>  25
<211>  22
<212>  DNA
<213>  artificial

<220>
<223>  primer HD3R2443

<400>  25
tgtgtttgtc tgtcaactct gg                                                22


<210>  26
<211>  31
<212>  RNA
<213>  artificial

<220>
<223>  oligoribonucleotide ss17-A14

<400>  26
ccccaccacc aucacuuaaa aaaaaaaaaa a                                      31


<210>  27
<211>  44
<212>  RNA
<213>  artificial

<220>
<223>  Oligoribonucleotide ss44

<400>  27
cgacuggagc acgaggacac ugacauggac ugaaggagua gaaa                        44


<210>  28
<211>  17
<212>  RNA
<213>  artificial

<220>
<223>  Oligoribonucleotide compl

<400>  28
aagugauggu ggugggg                                                      17


<210>  29
<211>  46
<212>  DNA
<213>  artificial

<220>
<223>  primer ADZKD134

<400>  29
agtgagtaac atcagcaata tggccaccaa cttcccaatt accgtt                      46


<210>  30
<211>  46
<212>  DNA
<213>  artificial

<220>
<223>  primer ADZKD136

<400>  30
tatacagaag tacctcttgc gggcccttcc gcatccaggg cagtgc                      46


<210>  31
<211>  45
<212>  DNA
<213>  artificial

<220>
<223>  primer ADZKD138

<400>  31
tgtgtagata tcaacggcta accggtagtg tctaaagtca ggata                       45


<210>  32
<211>  47
<212>  DNA
<213>  artificial

<220>
<223>  primer ADZKD140

<400>  32
atgggccaca acatcacagt aacgtttaat aggtgatgtg aaatgtg                     47


<210>  33
<211>  46
<212>  DNA
<213>  artificial

<220>
<223>  primer ADZKD133

<400>  33
aacggtaatt gggaagttgg tggccatatt gctgatgtta ctcact                      46


<210>  34
<211>  46
<212>  DNA
<213>  artificial

<220>
<223>  primer ADZKD135

<400>  34
gcactgccct ggatgcggaa gggcccgcaa gaggtacttc tgtata                      46


<210>  35
<211>  45
<212>  DNA
<213>  artificial

<220>
<223>  primer ADZKD137

<400>  35
tatcctgact ttagacacta ccggttagcc gttgatatct acaca                       45


<210>  36
<211>  47
<212>  DNA
<213>  artificial

<220>
<223>  primer ADZKD139

<400>  36
cacatttcac atcacctatt aaacgttact gtgatgttgt ggcccat                     47


<210>  37
<211>  20
<212>  DNA
<213>  artificial

<220>
<223>  primer ADZKD145

<400>  37
ggatgatgtt aattgcttgg                                                   20


<210>  38
<211>  20
<212>  DNA
<213>  artificial

<220>
<223>  primer ADZKD146

<400>  38
ttgaaactct accaccgacc                                                   20


<210>  39
<211>  20
<212>  DNA
<213>  artificial

<220>
<223>  primer RTADZ-9

<400>  39
gagatacatt gtgagggacc                                                   20


<210>  40
<211>  20
<212>  DNA
<213>  artificial

<220>
<223>  primer RTADZ-27

<400>  40
atgtcagttc ccgctatcgc                                                   20


<210>  41
<211>  20
<212>  DNA
<213>  artificial

<220>
<223>  primer ADZKD151

<400>  41
cgtcgttctt gttaccaacg                                                   20


<210>  42
<211>  20
<212>  DNA
<213>  artificial

<220>
<223>  primer ADZKD152

<400>  42
caccgtgatt tccgacaagc                                                   20


<210>  43
<211>  22
<212>  DNA
<213>  artificial

<220>
<223>  primer ADZ1601

<400>  43
gcccgcagaa ggccacgatt gg                                                22


<210>  44
<211>  22
<212>  DNA
<213>  artificial

<220>
<223>  primer RTADZ-68

<400>  44
agggctctct tgaaattgtc tg                                                22


<210>  45
<211>  22
<212>  DNA
<213>  artificial

<220>
<223>  primer ADZ1603

<400>  45
gacaggtgtg tggatcccga ag                                                22


<210>  46
<211>  29
<212>  DNA
<213>  artificial

<220>
<223>  primer ADZKD141

<400>  46
cctaaataga gcattcaacg gtgaccagg                                         29


<210>  47
<211>  29
<212>  DNA
<213>  artificial

<220>
<223>  primer ADZKD142

<400>  47
cctggtcacc gttgaatgct ctatttagg                                         29


<210>  48
<211>  19
<212>  DNA
<213>  artificial

<220>
<223>  oligonucleotide yeast 7S antisense

<400>  48
ggccagcaat ttcaagtta                                                    19


<210>  49
<211>  17
<212>  DNA
<213>  artificial

<220>
<223>  oligonucleotide yeast 5.8S antisense

<400>  49
gcgttgttca tcgatgc                                                      17


<210>  50
<211>  16
<212>  DNA
<213>  artificial

<220>
<223>  oligonucleotide yeast 5S antisense

<400>  50
ctactcggtc aggctc                                                       16


<210>  51
<211>  40
<212>  DNA
<213>  artificial

<220>
<223>  primer D3FMluI

<400>  51
atatacgcgt gccgccacca tgctcaagtc caagacgttc                             40


<210>  52
<211>  63
<212>  DNA
<213>  artificial

<220>
<223>  primer D3RB120I

<400>  52
gcgcgggccc ttacttgtcg tcgtcgtcct tgtaatctat atcttttcca agcttcatct       60

tct                                                                     63


<210>  53
<211>  45
<212>  DNA
<213>  artificial

<220>
<223>  primer eGFPFor

<400>  53
gcggaattca tatacctagg accatggtga gcaagggcga ggagc                       45


<210>  54
<211>  46
<212>  DNA
<213>  artificial

<220>
<223>  primer eGFPRev

<400>  54
gcgcgtcgac tcactacctc ctcttacttg tacagctcgt ccatgc                      46


<210>  55
<211>  20
<212>  DNA
<213>  artificial

<220>
<223>  primer hD3r819R

<400>  55
cttgttctcc tcggaatctc                                                   20


<210>  56
<211>  20
<212>  DNA
<213>  artificial

<220>
<223>  primer BI16seq1

<400>  56
cattctccgc tccatcgttc                                                   20


<210>  57
<211>  20
<212>  DNA
<213>  artificial

<220>
<223>  primer BI16seq2

<400>  57
tccactggtc gactcactac                                                   20


<210>  58
<211>  20
<212>  DNA
<213>  artificial

<220>
<223>  primer GAPDH_F

<400>  58
tgcaccacca actgcttagc                                                   20


<210>  59
<211>  21
<212>  DNA
<213>  artificial

<220>
<223>  primer GAPDH_R

<400>  59
ggcatggact gtggtcatga g                                                 21


<210>  60
<211>  20
<212>  DNA
<213>  artificial

<220>
<223>  primer 7SL_F

<400>  60
tcgggtgtcc gcactaagtt                                                   20


<210>  61
<211>  19
<212>  DNA
<213>  artificial

<220>
<223>  primer 7SL-R

<400>  61
tggctattca caggcgcga                                                    19


<210>  62
<211>  19
<212>  DNA
<213>  artificial

<220>
<223>  oligonucleotide human 5.8S rRNA precursor  antisense

<400>  62
gcgattgatc ggcaagcga                                                    19


<210>  63
<211>  32
<212>  DNA
<213>  artificial

<220>
<223>  oligonucleotide human 5.8S rRNA antisense

<400>  63
tcctgcaatt cacattaatt ctcgcagcta gc                                     32


<210>  64
<211>  22
<212>  DNA
<213>  artificial

<220>
<223>  oligonucleotide human 5S rRNA antisense oligo

<400>  64
catccaagta ctaaccaggc cc                                                22


<210>  65
<211>  30
<212>  DNA
<213>  artificial

<220>
<223>  oligonucleotide human tRNA AsnGTT antisense oligo

<400>  65
accaaccttt cggttaacag ccgaacgcgc                                        30


<210>  66
<211>  30
<212>  DNA
<213>  artificial

<220>
<223>  oligonucleotide human tRNA AspGTC antisense oligo

<400>  66
cggtctcccg cgtgacaggc ggggatactc                                        30


<210>  67
<211>  30
<212>  DNA
<213>  artificial

<220>
<223>  oligonucleotide human tRNA HisGTG antisense oligo

<400>  67
cgaggttgct gcggccacaa cgcagagtac                                        30


<210>  68
<211>  30
<212>  DNA
<213>  artificial

<220>
<223>  oligonucleotide human tRNA TrpCCA antisense oligo

<400>  68
cgcaaccttc tgatctggag tcagacgcgc                                        30


<210>  69
<211>  30
<212>  DNA
<213>  artificial

<220>
<223>  oligonucleotide human tRNA TyrGTA antisense oligo

<400>  69
gacctaagga tctacagtcc tccgctctac                                        30


<210>  70
<211>  30
<212>  DNA
<213>  artificial

<220>
<223>  oligonucleotide human tRNA LysTTT (1,2) antisense oligo

<400>  70
gaccctcaga ttaaaagtct gatgctctac                                        30


<210>  71
<211>  30
<212>  DNA
<213>  artificial

<220>
<223>  oligonucleotide human tRNA PheGAA antisense oligo

<400>  71
ggacctttag atcttcagtc taacgctctc                                        30


<210>  72
<211>  30
<212>  DNA
<213>  artificial

<220>
<223>  oligonucleotide human tRNA CysGCA antisense oligo

<400>  72
gggacctctt gatctgcagt caaatgctct                                        30


<210>  73
<211>  22
<212>  DNA
<213>  artificial

<220>
<223>  oligonucleotide human RNase P RNA antisense oligo

<400>  73
atgggcggag gagagtagtc tg                                                22


<210>  74
<211>  21
<212>  DNA
<213>  artificial

<220>
<223>  oligonucleotide human RNase MRP RNA antisense oligo

<400>  74
gccgcgctga gaatgagccc c                                                 21


<210>  75
<211>  30
<212>  DNA
<213>  artificial

<220>
<223>  oligonucleotide human U2 snRNA antisense oligo

<400>  75
gggtgcaccg ttcctggagg tactgcaata                                        30


<210>  76
<211>  30
<212>  DNA
<213>  artificial

<220>
<223>  oligonucleotide human U5 snRNA antisense oligo

<400>  76
ttgggttaag actcagagtt gttcctctcc                                        30


<210>  77
<211>  20
<212>  DNA
<213>  artificial

<220>
<223>  oligonucleotide human U6 snRNA antisense oligo

<400>  77
gaacgcttca cgaatttgcg                                                   20


<210>  78
<211>  30
<212>  DNA
<213>  artificial

<220>
<223>  oligonucleotide human U3 snoRNA antisense oligo

<400>  78
accactcaga ccgcgttctc tccctctcac                                        30


<210>  79
<211>  20
<212>  DNA
<213>  artificial

<220>
<223>  primer GAPDH Forward

<400>  79
gtcagccgca tcttcttttg                                                   20


<210>  80
<211>  20
<212>  DNA
<213>  artificial

<220>
<223>  primer GAPDH Reverse

<400>  80
gcgcccaata cgaccaaatc                                                   20


<210>  81
<211>  20
<212>  DNA
<213>  artificial

<220>
<223>  primer 40-2b PROM Forward

<400>  81
gggagtctaa ggaaaaggag                                                   20


<210>  82
<211>  20
<212>  DNA
<213>  artificial

<220>
<223>  primer 40-2b PROM Reverse

<400>  82
cagtgaaagg agagcgtatc                                                   20


<210>  83
<211>  20
<212>  DNA
<213>  artificial

<220>
<223>  primer 40-13 PROMPT Forward

<400>  83
ggaaatagtg gagaaaagca                                                   20


<210>  84
<211>  20
<212>  DNA
<213>  artificial

<220>
<223>  primer 40-13 PROMPT Reverse

<400>  84
catttttgaa ggaacggtag                                                   20


<210>  85
<211>  20
<212>  DNA
<213>  artificial

<220>
<223>  primer 40-33 PROMPT  Forward

<400>  85
ctggcctagc taaagtctca                                                   20


<210>  86
<211>  20
<212>  DNA
<213>  artificial

<220>
<223>  primer 40-33 PROMPT Reverse

<400>  86
tctgctccta gctctcagtc                                                   20


<210>  87
<211>  20
<212>  DNA
<213>  artificial

<220>
<223>  primer 40-52 PROMPT Forward

<400>  87
agttccaaga aaccacacac                                                   20


<210>  88
<211>  20
<212>  DNA
<213>  artificial

<220>
<223>  primer 40-52 PROMPT Reverse

<400>  88
ggtcgtttga gtggactaac                                                   20


<210>  89
<211>  20
<212>  DNA
<213>  artificial

<220>
<223>  primer 40-13 gene Forward

<400>  89
ggagttgaca gcagagtttt                                                   20


<210>  90
<211>  20
<212>  DNA
<213>  artificial

<220>
<223>  primer 40-13 gene Reverse

<400>  90
atgcacttta accaggtttg                                                   20


<210>  91
<211>  20
<212>  DNA
<213>  artificial

<220>
<223>  primer 40-33 gene Forward

<400>  91
ggtgacaact ggtctctgtc                                                   20


<210>  92
<211>  20
<212>  DNA
<213>  artificial

<220>
<223>  primer 40-33 gene Reverse

<400>  92
ccgaaagtta ccaaaacatt                                                   20


<210>  93
<211>  20
<212>  DNA
<213>  artificial

<220>
<223>  primer 40-52 gene Forward

<400>  93
aaaatgagac tggccactaa                                                   20


<210>  94
<211>  20
<212>  DNA
<213>  artificial

<220>
<223>  primer 40-52 gene  Reverse

<400>  94
gatgtgggat tctctcaaac                                                   20


<210>  95
<211>  22
<212>  DNA
<213>  artificial

<220>
<223>  primer mtATP6/8 Forward

<400>  95
ccatcagcct actcattcaa cc                                                22


<210>  96
<211>  22
<212>  DNA
<213>  artificial

<220>
<223>  primer mtATP6/8  Reverse

<400>  96
gcgacagcga tttctaggat ag                                                22


<210>  97
<211>  43
<212>  DNA
<213>  artificial

<220>
<223>  primer D3PINF

<400>  97
aggaataacc gggcgattcg agtagcagca aaatggtaca atg                         43


<210>  98
<211>  42
<212>  DNA
<213>  artificial

<220>
<223>  primer D3PINR

<400>  98
tcgaatcgcc cggttattcc tgtcattagc attttctccc tg                          42


