                         SEQUENCE LISTING

<110>  Imperial Innovations Limited
 
<120>  Polypeptides

<130>  P57315WO/NJL

<150>  GB1309421.4	
<151>  2013-05-24

<160>  6     

<170>  PatentIn version 3.5

<210>  1
<211>  418
<212>  PRT
<213>  Homo sapiens

<400>  1

Met Arg Glu Ser Gln Asp Ala Ala Gly Ala His Gly Trp Asn Arg Val 
1               5                   10                  15      


Gly Ser Thr Ala Thr Lys Trp Phe Thr Gly Ala Pro Phe Gly Val Gln 
            20                  25                  30          


Ser His Arg Phe Asp Ile Ser Ala Val Tyr Pro Asn Trp Lys Lys Phe 
        35                  40                  45              


Ser Thr Phe Thr Glu Ala Pro Tyr Ser Thr Arg Tyr Ser Thr Gln Val 
    50                  55                  60                  


Ser His Ile Gly Pro Gly Thr Tyr Ser Ser Lys Glu Thr Cys Phe Ser 
65                  70                  75                  80  


Lys Lys Lys Leu Met Lys Glu Val Asp Thr Gly Trp Ala Lys Ala Gln 
                85                  90                  95      


Glu Ala Thr Arg Leu Thr Gln Leu Pro His Phe Gln Tyr Gln Ala Ile 
            100                 105                 110         


Met Lys Glu Lys Arg Leu Lys Glu Gln Lys Leu Gly Pro Gly Ser Tyr 
        115                 120                 125             


Asn Leu Lys Asp Phe Leu Glu Gln Leu Arg Glu Lys Pro Cys Ser Thr 
    130                 135                 140                 


Arg Gly Leu Leu Ser Ser Gly Glu Val Arg Phe Arg Gly Leu Thr Gly 
145                 150                 155                 160 


Asn Tyr Tyr Pro Gly Pro Gly Asn Tyr Gly Glu Lys Gly Asn Pro Tyr 
                165                 170                 175     


Thr Lys Leu Glu Glu Asn Ala Trp Asn Arg Ser His Ser Glu Gly Leu 
            180                 185                 190         


Met Cys Arg Met Ser Asn Lys Pro His Pro Arg Pro Tyr Gln Gly Ser 
        195                 200                 205             


Gly Leu Gly Pro Gly Thr Tyr Phe Phe Lys Ser Asp Leu Glu Thr Tyr 
    210                 215                 220                 


Val Ala Arg Ser Val Gly Thr Arg Gly Pro Tyr Asp Thr Phe Ser Gly 
225                 230                 235                 240 


Asp Arg Ser Lys Pro Leu Pro Tyr Gly His Tyr Ser Met Gln Lys Lys 
                245                 250                 255     


Lys Pro Arg Glu Leu Met Asn Phe Lys Ser Phe Val Glu Glu Leu Asn 
            260                 265                 270         


Ser His His Asn Lys Lys His Gly Val Phe Ser Lys Leu Pro Arg Asn 
        275                 280                 285             


Pro Lys Thr Pro Thr Glu Arg Ile Tyr Trp Ala Asn Leu Ser Gln Cys 
    290                 295                 300                 


Pro Arg Thr Leu Ala Thr Ser Gly Pro Ser Phe Trp Leu Pro Gln Glu 
305                 310                 315                 320 


Lys Lys Cys Lys Pro Val Asn Gln Pro Pro Phe Leu Leu Thr Ser Lys 
                325                 330                 335     


Gly Ser Gly Ala Lys Ala Cys Gln Met Ile Met Gly Ser Trp Asn Pro 
            340                 345                 350         


Val Gly Val Gly Arg Tyr Leu Asn Thr Trp Leu Met Glu Thr Lys Asp 
        355                 360                 365             


Arg Arg Gln Arg Tyr Arg Ser Leu Phe Leu Ser Gly Ser Lys Arg Tyr 
    370                 375                 380                 


Leu Ser Asp Leu Ala Arg Asp Met Leu Met Gln Glu Arg Ile Thr Pro 
385                 390                 395                 400 


Phe Thr Lys Gly Lys Cys Pro Pro Thr Val Asp Tyr Asn Ser Asp Pro 
                405                 410                 415     


Thr Pro 
        


<210>  2
<211>  414
<212>  PRT
<213>  Mus musculus

<400>  2

Met Arg Pro Arg Thr His Gly Ala Pro Pro Arg Asn Ile Met Ser Thr 
1               5                   10                  15      


Ile Pro Lys Trp Phe Lys Gly Ala Pro Phe Gly Val Gln Ser His Arg 
            20                  25                  30          


Phe Asp Val Ser Ala Val Tyr Pro Asn Gln Lys Lys Phe Ser Thr Phe 
        35                  40                  45              


Thr Glu Ala Pro Tyr Ser Arg His His Ser Val Glu Leu Ser His Ile 
    50                  55                  60                  


Gly Pro Gly Thr Tyr Asn Ser Lys Asp Thr Cys Phe Ser Lys Lys Phe 
65                  70                  75                  80  


Leu Glu Gln Lys Leu Gly Ser Gly Trp Ser Gln Ala His Glu Ala Thr 
                85                  90                  95      


Arg Leu Thr Gln Leu Pro His Phe His Tyr Gln Ala Ile Lys Lys Glu 
            100                 105                 110         


Lys Glu Gln Gln Val His Lys Arg Gly Pro Gly Ser Tyr Asn Ile Lys 
        115                 120                 125             


Asp Phe Ile Thr Glu Leu Gln Lys Lys Pro Gln Ser Lys Arg Gly Leu 
    130                 135                 140                 


Leu Ser Ser Gly Glu Thr Arg Phe Arg Gly Phe Ile Gly Asn Tyr Tyr 
145                 150                 155                 160 


Pro Gly Pro Gly Asn Tyr Gly Glu Lys Gly Asn Pro Tyr Thr Gln Leu 
                165                 170                 175     


Glu Glu Lys Ala Trp Asn Arg Ser His Ser Asp Gly Leu Met Cys Arg 
            180                 185                 190         


Val Ser Asn Lys Pro Pro Leu Phe His Gln Gly Ser Gly Leu Gly Pro 
        195                 200                 205             


Gly Thr Tyr Thr Ile Lys Ser Asp Leu Glu Thr Phe Val Lys Lys Ser 
    210                 215                 220                 


Thr Gly Asn Arg Gly Pro Tyr Asp Ile Phe Ser Gly Glu Arg Ser Ser 
225                 230                 235                 240 


Pro Leu Pro Tyr Gly His Tyr Ser Val Gln Lys Met Lys Pro Lys Glu 
                245                 250                 255     


Leu Thr Asp Tyr Lys Ser Phe Leu Asp Glu Met Asn Ser Gln His Lys 
            260                 265                 270         


Lys Lys Gln Gly Val Phe Ser Lys Tyr Pro Arg Asp Pro Lys His Pro 
        275                 280                 285             


Thr Glu Arg Ile Phe Trp Thr Thr Leu Ser Gln Cys Pro Lys Asn Met 
    290                 295                 300                 


Asp Ile Ala Gly Pro Gly Ser Trp Leu Pro His Glu Thr Glu Gln Lys 
305                 310                 315                 320 


His Val Asn Arg Pro Pro Phe Leu Leu Ala Ser Lys Arg Cys Gly Leu 
                325                 330                 335     


Lys Ala Tyr Gln Met Ile Leu Gly Thr Trp Asn Pro Val Gly Val Gly 
            340                 345                 350         


Arg Tyr Leu Asn Thr Thr Leu Met Glu Ser Ile Asp Arg Arg Gln Arg 
        355                 360                 365             


Tyr Arg Ser Leu Tyr Met Ser Glu Pro Lys Arg Tyr Leu Gln Asp Leu 
    370                 375                 380                 


Thr Arg Asp Arg Leu Met Gln Lys Arg Ile Thr Pro Ile Thr Lys Gly 
385                 390                 395                 400 


Lys Cys Arg Pro Thr Val Asp Tyr Asn Ser Asp Pro Thr Pro 
                405                 410                 


<210>  3
<211>  1257
<212>  DNA
<213>  Homo sapiens

<400>  3
atgagggaaa gccaggatgc cgccggagct catggctgga accgcgtcgg ctccacggcc       60

accaagtggt tcaccggggc gcccttcggg gtgcagagcc acaggtttga catctctgct      120

gtttatccca actggaagaa gttcagcacc ttcactgagg ccccatactc cacgcgttat      180

tctacccaag tgtcccacat aggccctggg acttacagct ccaaagagac ctgcttcagc      240

aagaagaagc tgatgaagga ggtggacaca ggctgggcca aggcccagga agccacgcgg      300

ctgacccagc taccccactt ccagtaccag gccatcatga aagagaagcg gctgaaggag      360

caaaagctgg gccccggctc ctacaacctc aaagacttct tagaacagct gcgggagaaa      420

ccatgtagca cccgggggct gctcagctct ggggaggttc gcttccgagg actcactggg      480

aactactatc caggccctgg aaattatggg gagaagggta acccatacac caagctggag      540

gagaatgcct ggaaccggtc tcattccgag ggcctcatgt gcaggatgag caacaagcca      600

cacccccggc cttatcaggg gagtggtctg ggacccggca cctacttctt caaaagcgac      660

cttgagacat atgtggcacg atccgtcggc acccgcggcc cctatgacac tttctctggt      720

gatcggagca agccactgcc ttatgggcac tactccatgc agaaaaaaaa gcccagggaa      780

ctgatgaatt tcaagagctt tgtagaagaa cttaactcac atcacaataa gaagcatggg      840

gttttttcta aacttccccg aaacccgaaa acccctacag agaggattta ctgggccaac      900

ctcagccagt gcccccgcac actggccaca tctggcccca gtttctggct tccacaagag      960

aagaaatgca aacccgtcaa ccagccccca ttcctgttga cctccaaggg gtcaggtgca     1020

aaggcctgcc agatgattat gggaagctgg aacccagtag gtgtgggccg ctacctcaac     1080

acctggctga tggagacaaa ggacaggcgg cagcgatatc gatccctatt cctgagtgga     1140

tccaaacgct acctctcaga cctggcccgg gacatgctca tgcaggaaag gatcacacca     1200

tttactaagg gaaagtgccc tccaactgtg gattacaatt cagatcctac tccttaa        1257


<210>  4
<211>  1245
<212>  DNA
<213>  Mus musculus

<400>  4
atgagacctc gcacccacgg cgcccccccg cgcaacatca tgtccaccat ccccaagtgg       60

ttcaaagggg cgccctttgg ggtgcagagc cacaggtttg atgtctccgc tgtctatccc      120

aaccagaaga aattcagcac cttcacagag gccccatact ccagacatca ttcggtggaa      180

ctgtcccaca taggacctgg gacctataac tccaaggata cctgcttcag caagaagttc      240

ctggaacaga agttgggctc aggatggtcc caggcccacg aagccactcg gctgacccag      300

ctaccccact tccactacca ggccatcaag aaggaaaaag agcagcaggt gcacaagcgt      360

ggccctggct cctacaacat caaagacttc ataactgagc tgcagaagaa accacagagc      420

aaacgggggc tgctcagctc tggggagaca cgtttccgag gttttattgg gaattattat      480

cctggccctg gagattatgg ggagaagggg aacccgtaca cacagctgga ggagaaggcc      540

tggaaccgct cacattctga cggcctgatg tgtagagtgt ctaacaagcc acccttgttt      600

catcagggca gtggcctggg acctggtacc tacaccatca aaagcgatct tgagaccttt      660

gtgaaaaagt ccactggtaa tcgtggcccc tatgacattt tctctggtga acggagcagt      720

cctttgccct atggacatta ctctgtgcag aaaatgaagc ccaaggaact gacagattac      780

aagagctttc tggacgaaat gaactcacaa cacaagaaga aacaaggggt tttctcgaaa      840

tatccccgag atccgaaaca ccccacagag agaattttct ggacaaccct tagtcagtgc      900

cccaaaaata tggatatagc tggccctggt tcttggcttc ctcatgagac ggaacagaaa      960

catgtcaacc ggccaccgtt cctcctggcc tccaaacggt gcggcctaaa ggcctaccag     1020

atgattttgg gaacctggaa cccagttggc gtaggccgct atctcaacac cacgctgatg     1080

gagtccatag accgaaggca gcgataccgt tctctgtaca tgagtgagcc caagcgatac     1140

ctgcaagacc taacccgaga cagactcatg cagaaacgga ttacacctat tacgaagggc     1200

aagtgccgtc caactgtgga ctacaattca gatcctactc cttaa                     1245


<210>  5
<211>  5259
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Retro protein vector sequence

<400>  5
atgctgaatg agggcatcgt tcccactgcg atgctggttg ccaacgatca gatggcgctg       60

ggcgcaatgc gcgccattac cgagtccggg ctgcgcgttg gtgcggatat ctcggtagtg      120

ggatacgacg ataccgaaga tagctcatgt tatatcccgc cgttaaccac catcaaacag      180

gattttcgcc tgctggggca aaccagcgtg gaccgcttgc tgcaactctc tcagggccag      240

gcggtgaagg gcaatcagct gttgccagtc tcactggtga aaagaaaaac caccctggcg      300

cccaatacgc aaaccgcctc tccccgcgcg ttggccgatt cattaatgca gctggcacga      360

caggtttccc gactggaaag cgggcagtga ctcatgacca aaatccctta acgtgagtta      420

cgcgcgcgtc gttccactga gcgtcagacc ccgtagaaaa gatcaaagga tcttcttgag      480

atcctttttt tctgcgcgta atctgctgct tgcaaacaaa aaaaccaccg ctaccagcgg      540

tggtttgttt gccggatcaa gagctaccaa ctctttttcc gaaggtaact ggcttcagca      600

gagcgcagat accaaatact gttcttctag tgtagccgta gttagcccac cacttcaaga      660

actctgtagc accgcctaca tacctcgctc tgctaatcct gttaccagtg gctgctgcca      720

gtggcgataa gtcgtgtctt accgggttgg actcaagacg atagttaccg gataaggcgc      780

agcggtcggg ctgaacgggg ggttcgtgca cacagcccag cttggagcga acgacctaca      840

ccgaactgag atacctacag cgtgagctat gagaaagcgc cacgcttccc gaagggagaa      900

aggcggacag gtatccggta agcggcaggg tcggaacagg agagcgcacg agggagcttc      960

cagggggaaa cgcctggtat ctttatagtc ctgtcgggtt tcgccacctc tgacttgagc     1020

gtcgattttt gtgatgctcg tcaggggggc ggagcctatg gaaaaacgcc agcaacgcgg     1080

cctttttacg gttcctggcc ttttgctggc cttttgctca catgttcttt cctgcgttat     1140

cccctgattc tgtggataac cgtattaccg cctttgagtg agctgatacc gctcgccgca     1200

gccgaacgac cgagcgcagc gagtcagtga gcgaggaagc ggaaggcgag agtagggaac     1260

tgccaggcat caaactaagc agaaggcccc tgacggatgg cctttttgcg tttctacaaa     1320

ctctttctgt gttgtaaaac gacggccagt cttaagctcg ggccccctgg gcggttctga     1380

taacgagtaa tcgttaatcc gcaaataacg taaaaacccg cttcggcggg tttttttatg     1440

gggggagttt agggaaagag catttgtcag aatatttaag ggcgcctgtc actttgcttg     1500

atatatgaga attatttaac cttataaatg agaaaaaagc aacgcacttt aaataagata     1560

cgttgctttt tcgattgatg aacacctata attaaactat tcatctatta tttatgattt     1620

tttgtatata caatatttct agtttgttaa agagaattaa gaaaataaat ctcgaaaata     1680

ataaagggaa aatcagtttt tgatatcaaa attatacatg tcaacgataa tacaaaatat     1740

aatacaaact ataagatgtt atcagtattt attatgcatt tagaataaat tttgtgtcgc     1800

ccttaattgt gagcggataa caattacgag cttcatgcac agtgaaatca tgaaaaattt     1860

atttgctttg tgagcggata acaattataa tatgtggaat tgtgagcgct cacaattcca     1920

caacggtttc cctctagaaa taattttgtt taacttttag gaggtaaaac atatgcatca     1980

tcaccaccat cattctagcg gcgtcgattt gggcacggag aacttgtatt ttcaaagcat     2040

gcgcgagtct caggacgcag cgggtgccca cggttggaac cgtgttggtt ctaccgcgac     2100

taaatggttt accggtgcgc cgttcggcgt tcagagccac cgctttgaca ttagcgcggt     2160

gtatccgaac tggaagaaat tctccacctt taccgaggcc ccgtactcca cgcgttacag     2220

cacccaagtc agccacattg gtccgggcac gtacagcagc aaagaaacct gtttctctaa     2280

gaagaagctg atgaaagagg tggataccgg ctgggcgaaa gctcaggaag caacccgcct     2340

gacgcagctg ccgcactttc aataccaggc aatcatgaaa gaaaaacgtc tgaaagagca     2400

aaagctgggt ccgggtagct acaacctgaa ggacttcctg gagcagctgc gcgagaagcc     2460

gtgcagcacc cgtggcctgc tgagcagcgg tgaggtgcgc tttcgtggtc tgacgggtaa     2520

ctactacccg ggtccaggta actatggcga gaagggtaat ccttatacga aattggaaga     2580

gaatgcgtgg aaccgttccc acagcgaggg tctgatgtgc cgtatgagca ataaaccgca     2640

tcctcgcccg taccagggta gcggcttggg ccctggtacc tatttcttca agagcgacct     2700

ggaaacgtat gtggctcgta gcgtcggtac gcgtggcccg tacgatacct ttagcggtga     2760

tcgtagcaaa ccgctgccgt atggtcacta ttctatgcag aagaagaaac cacgcgaact     2820

gatgaatttc aaaagcttcg tcgaagagct gaatagccat cacaacaaga agcacggtgt     2880

ttttagcaag ctgccgcgta acccaaaaac cccgaccgaa cgtatttact gggcgaatct     2940

gagccagtgc ccgcgtactc tggccaccag cggtccaagc ttctggctgc cgcaagaaaa     3000

gaaatgcaaa ccggtgaatc aaccgccgtt tctgctgacg tccaaaggct cgggcgcaaa     3060

agcgtgtcaa atgatcatgg gttcgtggaa tccggttggt gttggccgtt acctgaatac     3120

ctggttgatg gaaaccaagg accgccgtca acgctatcgt agcctgttct tgagcggcag     3180

caaacgttac ctgtccgacc tggcccgtga tatgctgatg caggagcgca tcaccccgtt     3240

caccaagggc aagtgtccgc cgacggttga ctacaacagc gatccgacgc cgtaactcga     3300

gccccaaggg cgacaccccc taattagccc gggcgaaagg cccagtcttt cgactgagcc     3360

tttcgtttta tttgatgcct ggcagttccc tactctcgca tggggagtcc ccacactacc     3420

atcggcgcta cggcgtttca cttctgagtt cggcatgggg tcaggtggga ccaccgcgct     3480

actgccgcca ggcaaacaag gggtgttatg agccatattc aggtataaat gggctcgcga     3540

taatgttcag aattggttaa ttggttgtaa cactgacccc tatttgttta tttttctaaa     3600

tacattcaaa tatgtatccg ctcatgagac aataaccctg ataaatgctt caataatatt     3660

gaaaaaggaa gaatatgagc catattcaac gggaaacgtc gaggccgcga ttaaattcca     3720

acatggatgc tgatttatat gggtataaat gggctcgcga taatgtcggg caatcaggtg     3780

cgacaatcta tcgcttgtat gggaagcccg atgcgccaga gttgtttctg aaacatggca     3840

aaggtagcgt tgccaatgat gttacagatg agatggtcag actaaactgg ctgacggaat     3900

ttatgccact tccgaccatc aagcatttta tccgtactcc tgatgatgca tggttactca     3960

ccactgcgat ccccggaaaa acagcgttcc aggtattaga agaatatcct gattcaggtg     4020

aaaatattgt tgatgcgctg gcagtgttcc tgcgccggtt gcactcgatt cctgtttgta     4080

attgtccttt taacagcgat cgcgtatttc gcctcgctca ggcgcaatca cgaatgaata     4140

acggtttggt tgatgcgagt gattttgatg acgagcgtaa tggctggcct gttgaacaag     4200

tctggaaaga aatgcataaa cttttgccat tctcaccgga ttcagtcgtc actcatggtg     4260

atttctcact tgataacctt atttttgacg aggggaaatt aataggttgt attgatgttg     4320

gacgagtcgg aatcgcagac cgataccagg atcttgccat cctatggaac tgcctcggtg     4380

agttttctcc ttcattacag aaacggcttt ttcaaaaata tggtattgat aatcctgata     4440

tgaataaatt gcagtttcat ttgatgctcg atgagttttt ctaagcggcg cgccatcgaa     4500

tggcgcaaaa cctttcgcgg tatggcatga tagcgcccgg aagagagtca attcagggtg     4560

gtgaatatga aaccagtaac gttatacgat gtcgcagagt atgccggtgt ctcttatcag     4620

accgtttccc gcgtggtgaa ccaggccagc cacgtttctg cgaaaacgcg ggaaaaagtg     4680

gaagcggcga tggcggagct gaattacatt cccaaccgcg tggcacaaca actggcgggc     4740

aaacagtcgt tgctgattgg cgttgccacc tccagtctgg ccctgcacgc gccgtcgcaa     4800

attgtcgcgg cgattaaatc tcgcgccgat caactgggtg ccagcgtggt ggtgtcgatg     4860

gtagaacgaa gcggcgtcga agcctgtaaa gcggcggtgc acaatcttct cgcgcaacgc     4920

gtcagtgggc tgatcattaa ctatccgctg gatgaccagg atgccattgc tgtggaagct     4980

gcctgcacta atgttccggc gttatttctt gatgtctctg accagacacc catcaacagt     5040

attattttct cccatgagga cggtacgcga ctgggcgtgg agcatctggt cgcattgggt     5100

caccagcaaa tcgcgctgtt agcgggccca ttaagttctg tctcggcgcg tctgcgtctg     5160

gctggctggc ataaatatct cactcgcaat caaattcagc cgatagcgga acgggaaggc     5220

gactggagtg ccatgtccgg ttttcaacaa accatgcaa                            5259


<210>  6
<211>  440
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  6xHis-TEV-Retro(1-418)_optEC protein sequence

<400>  6

Met His His His His His His Ser Ser Gly Val Asp Leu Gly Thr Glu 
1               5                   10                  15      


Asn Leu Tyr Phe Gln Ser Met Arg Glu Ser Gln Asp Ala Ala Gly Ala 
            20                  25                  30          


His Gly Trp Asn Arg Val Gly Ser Thr Ala Thr Lys Trp Phe Thr Gly 
        35                  40                  45              


Ala Pro Phe Gly Val Gln Ser His Arg Phe Asp Ile Ser Ala Val Tyr 
    50                  55                  60                  


Pro Asn Trp Lys Lys Phe Ser Thr Phe Thr Glu Ala Pro Tyr Ser Thr 
65                  70                  75                  80  


Arg Tyr Ser Thr Gln Val Ser His Ile Gly Pro Gly Thr Tyr Ser Ser 
                85                  90                  95      


Lys Glu Thr Cys Phe Ser Lys Lys Lys Leu Met Lys Glu Val Asp Thr 
            100                 105                 110         


Gly Trp Ala Lys Ala Gln Glu Ala Thr Arg Leu Thr Gln Leu Pro His 
        115                 120                 125             


Phe Gln Tyr Gln Ala Ile Met Lys Glu Lys Arg Leu Lys Glu Gln Lys 
    130                 135                 140                 


Leu Gly Pro Gly Ser Tyr Asn Leu Lys Asp Phe Leu Glu Gln Leu Arg 
145                 150                 155                 160 


Glu Lys Pro Cys Ser Thr Arg Gly Leu Leu Ser Ser Gly Glu Val Arg 
                165                 170                 175     


Phe Arg Gly Leu Thr Gly Asn Tyr Tyr Pro Gly Pro Gly Asn Tyr Gly 
            180                 185                 190         


Glu Lys Gly Asn Pro Tyr Thr Lys Leu Glu Glu Asn Ala Trp Asn Arg 
        195                 200                 205             


Ser His Ser Glu Gly Leu Met Cys Arg Met Ser Asn Lys Pro His Pro 
    210                 215                 220                 


Arg Pro Tyr Gln Gly Ser Gly Leu Gly Pro Gly Thr Tyr Phe Phe Lys 
225                 230                 235                 240 


Ser Asp Leu Glu Thr Tyr Val Ala Arg Ser Val Gly Thr Arg Gly Pro 
                245                 250                 255     


Tyr Asp Thr Phe Ser Gly Asp Arg Ser Lys Pro Leu Pro Tyr Gly His 
            260                 265                 270         


Tyr Ser Met Gln Lys Lys Lys Pro Arg Glu Leu Met Asn Phe Lys Ser 
        275                 280                 285             


Phe Val Glu Glu Leu Asn Ser His His Asn Lys Lys His Gly Val Phe 
    290                 295                 300                 


Ser Lys Leu Pro Arg Asn Pro Lys Thr Pro Thr Glu Arg Ile Tyr Trp 
305                 310                 315                 320 


Ala Asn Leu Ser Gln Cys Pro Arg Thr Leu Ala Thr Ser Gly Pro Ser 
                325                 330                 335     


Phe Trp Leu Pro Gln Glu Lys Lys Cys Lys Pro Val Asn Gln Pro Pro 
            340                 345                 350         


Phe Leu Leu Thr Ser Lys Gly Ser Gly Ala Lys Ala Cys Gln Met Ile 
        355                 360                 365             


Met Gly Ser Trp Asn Pro Val Gly Val Gly Arg Tyr Leu Asn Thr Trp 
    370                 375                 380                 


Leu Met Glu Thr Lys Asp Arg Arg Gln Arg Tyr Arg Ser Leu Phe Leu 
385                 390                 395                 400 


Ser Gly Ser Lys Arg Tyr Leu Ser Asp Leu Ala Arg Asp Met Leu Met 
                405                 410                 415     


Gln Glu Arg Ile Thr Pro Phe Thr Lys Gly Lys Cys Pro Pro Thr Val 
            420                 425                 430         


Asp Tyr Asn Ser Asp Pro Thr Pro 
        435                 440 


