                         SEQUENCE LISTING

<110>  CANCER RESEARCH TECHNOLOGY LIMITED
 
<120>  TREATMENT

<130>  N119324B-WO

<150>  1309238.2
<151>  2013-05-22

<150>  1321115.6
<151>  2013-11-29

<160>  67    

<170>  PatentIn version 3.5

<210>  1
<211>  7695
<212>  DNA
<213>  Homo sapiens

<400>  1
atgaagcagc tgcagccgca gccgcctccg aagatggggg atttctacga cccggagcac       60

ccgacccctg aagaagaaga aaatgaggca aagattgaaa atgtgcagaa aacaggtttc      120

atcaaaggac caatgttcaa aggtgttgct tctagtcgat ttttgcccaa aggcaccaaa      180

acaaaagtta atttggaaga acagggacga cagaaggtgt cattcagctt cagccttaca      240

aagaaaactt tgcagaatag gtttctcact gcacttggca atgaaaagca aagtgatact      300

ccaaaccctc cagctgtacc tcttcaggta gactcgactc ctaaaatgaa aatggaaatt      360

ggtgatacct tatctactgc agaagaatct tccccaccaa agtcaagggt ggaattgggc      420

aaaattcatt ttaagaaaca tctgcttcat gtaacatcca ggccactgct ggctactacc      480

acagcagtag catctccacc tactcatgca gcaccattac cagcagtgat agcagaatca      540

acaactgtag actcaccgcc ctcatctccg cctccaccgc ctccacctgc ccaagccaca      600

acactctcat caccagcacc agtaacagag ccagtggcct tgccacatac accaataaca      660

gttctaatgg cagcaccagt acccttacca gtagatgtag cagttagatc tctgaaagaa      720

ccaccaatta taattgtacc agaatcttta gaagcagata ctaagcagga cactatatct      780

aatagtttag aagaacacgt aactcaaata ttgaatgagc aagcagatat ttcctcaaaa      840

aaagaagatt cccatattgg gaaggatgaa gaaattccag atagttctaa gattagtctg      900

agctgtaaaa aaacaggttc taagaagaaa tcctcacaat ctgaaggcat ctttcttggt      960

tcagaatctg atgaagattc tgtacggact tcttcaagtc aaagatcaca tgatttaaaa     1020

ttttcagcaa gcattgaaaa ggaaagagat tttaaaaaga gctcagcacc tttaaaaagt     1080

gaggatctag ggaaaccttc acgatctaaa acagacagag atgataaata ttttagctat     1140

tcaaaacttg aaagagatac tcggtatgta tcttcccgat gtagatcaga aagagagcga     1200

cggcggagca gatctcactc taggtctgag agaggctcta gaactaattt atcctattcc     1260

aggtcagaac gatctcatta ttatgactct gatcgtcgct accataggag ctccccttat     1320

cgagagagga cgcgctattc tcggccatac acagataaca gagcacgaga gagttctgac     1380

tcagaagaag agtataagaa gacatactca aggcgtacct catctcattc ctcttcttac     1440

agagacctaa ggacatcatc ctattctaaa tctgatcggg actgtaaaac tgagacctct     1500

tacttagaga tggaaagaag aggcaagtat tcttcaaaac tagaaagaga atctaaaagg     1560

acttcagaaa atgaagcaat taaaagatgt tgttctcccc ctaatgaact gggattccga     1620

cgagggtcat catattctaa gcatgacagt agtgcttccc gttataaatc taccctttca     1680

aaacctatac ccaagtctga taaatttaaa aattctttct gttgtacaga attaaatgaa     1740

gaaatcaaac agtctcattc ttttagttta cagacacctt gttcaaaagg tagtgaatta     1800

agaatgatta ataaaaatcc tgaaagagaa aaggctgggt ctccagctcc atcaaatcga     1860

ttaaatgatt cacctacttt aaaaaagcta gatgaattgc ctatttttaa gtccgaattt     1920

ataacacatg atagccatga tagtattaag gaattagact ctttatctaa agtgaagaat     1980

gatcaattaa gaagtttttg tcccatagaa ttaaatataa atggatctcc tggggcagaa     2040

tctgatttgg caacattttg cacttctaaa actgatgctg ttttaatgac ttctgatgat     2100

agtgtgactg gatcggaatt atcccctttg gtcaaagcat gcatgctttc atcaaatgga     2160

tttcagaata ttagtaggtg caaagaaaaa gacttggatg atacctgcat gctgcataag     2220

aagtcagaaa gcccatttag agaaacagaa cctctggtgt caccacacca agataaactc     2280

atgtctatgc cagttatgac tgtggattat tccaaaacag tagttaaaga accagttgat     2340

acgagggttt cttgctgcaa aaccaaagat tcagacatat actgtacttt gaacgatagc     2400

aacccttctt tgtgtaactc tgaagctgaa aatattgagc cttcagttat gaagatttct     2460

tcaaatagct ttatgaatgt gcatttggaa tcaaaaccag ttatatgtga tagtagaaat     2520

ttgacagatc actcaaaatt tgcatgtgaa gaatataagc agagcatcgg tagcactagt     2580

tcagcttctg ttaatcattt tgatgattta tatcaaccta ttgggagttc aggtattgct     2640

tcatctcttc agagtcttcc accaggaata aaggtggaca gtctaactct cttgaaatgc     2700

ggagagaaca catctccagt tctggatgca gtgctaaaga gtaaaaaaag ttcagagttt     2760

ttaaagcatg cagggaaaga aacaatagta gaagtaggta gtgaccttcc tgattcagga     2820

aagggatttg cttccaggga gaacaggcgt aataatgggt tatctgggaa atgtttgcaa     2880

gaggctcaag aagaagggaa ttccatattg cctgaaagaa gaggaagacc agaaatctct     2940

ttagatgaaa gaggagaagg aggacatgtg catacttctg atgactcaga agttgtattt     3000

tcttcttgtg atttgaattt aaccatggaa gacagtgatg gtgtaactta tgcattaaag     3060

tgtgacagta gtggtcatgc cccagaaatt gtgtctacag ttcatgaaga ttattctggc     3120

tcttctgaaa gttcaaatga tgaaagtgat tcagaagata cagattcgga tgatagcagt     3180

attccaagaa accgtctcca gtctgttgtg gttgtgccaa agaattctac tttgcccatg     3240

gaagaaacaa gtccttgttc ttctcggagc agtcaaagtt atagacacta ttctgaccat     3300

tgggaagatg agagattgga gtcaaggaga catttgtatg aggaaaaatt tgaaagtata     3360

gcaagtaaag cctgtcctca aactgataag tttttccttc ataaaggaac agagaagaat     3420

ccggaaattt cttttacaca gtccagtaga aaacaaatag ataatcgcct gcctgaactt     3480

tctcatcctc agagtgatgg ggttgatagt acaagtcata cagatgtgaa atctgaccct     3540

ctgggtcacc caaattcaga ggaaaccgtg aaagccaaaa taccttctag gcagcaagaa     3600

gagctgccaa tttattcttc tgattttgaa gatgtcccaa ataagtcttg gcaacagacc     3660

actttccaaa acaggccaga tagtagactg ggaaaaacag aattgagttt ttcttcctct     3720

tgtgagatac cacatgtgga tggcttgcac tcatcagaag agctcagaaa cttaggttgg     3780

gacttctctc aagaaaagcc ttctaccacg tatcagcaac ctgacagtag ctatggagct     3840

tgtggtggac acaagtatca gcaaaatgca gaacagtatg gtgggacacg tgattactgg     3900

caaggcaatg gttactggga tccaagatca ggtagacctc ctggaactgg ggttgtgtat     3960

gatcgaactc aaggacaagt accagattcc ctaacagatg atcgtgaaga agaggagaat     4020

tgggatcaac aggatggatc ccatttttca gaccagtccg ataaatttct tctatccctt     4080

cagaaagaca aggggtcagt gcaagcacct gaaataagca gcaattccat taaggacact     4140

ttagctgtga atgaaaagaa agatttttca aaaaacttag aaaaaaatga tatcaaagat     4200

agagggcctc ttaaaaaaag gaggcaggaa atagagagtg attctgaaag tgatggtgag     4260

cttcaggaca gaaagaaagt tagagtggag gtagagcagg gagagacatc agtgccccca     4320

ggttcagcac tggttgggcc ctcctgtgtc atggatgact tcagggaccc acagcgatgg     4380

aaggaatgtg ccaagcaagg gaaaatgcca tgttactttg atcttattga agaaaatgtt     4440

tatttaacag aaagaaagaa gaataaatct catcgagata ttaagcgaat gcagtgtgag     4500

tgtacacctc tttctaaaga tgaaagagct caaggtgaaa tagcatgtgg ggaagattgt     4560

cttaatcgtc ttctcatgat tgaatgttct tctcggtgtc caaatgggga ttattgttcc     4620

aatagacggt ttcagagaaa acagcatgca gatgtggaag tcatactcac agaaaagaaa     4680

ggctggggct tgagagctgc caaagacctt ccttcgaaca cctttgtcct agaatattgt     4740

ggagaggtac tcgatcataa agagtttaaa gctcgagtga aggagtatgc acgaaacaaa     4800

aacatccatt actatttcat ggccctgaag aatgatgaga taatagatgc cactcaaaaa     4860

ggaaattgct ctcgtttcat gaatcacagc tgtgaaccaa attgtgaaac ccaaaaatgg     4920

actgtgaacg gacaactgag ggttgggttt tttaccacca aactggttcc ttcaggctca     4980

gagttaacgt ttgactatca gttccagaga tatggaaaag aagcccagaa atgtttctgc     5040

ggatcagcca attgccgggg ttacctggga ggagaaaaca gagtcagcat cagagcagca     5100

ggagggaaaa tgaagaagga acgatctcgt aagaaggatt cagtggatgg agagctagaa     5160

gctctgatgg aaaatggtga gggtctctct gataaaaacc aggtgctcag cttatcccgg     5220

ctaatggtta gaattgaaac tttggagcag aaacttacct gtctggaact catacagaac     5280

acacactcac agtcctgcct gaagtccttt ctggaacgtc atgggctgtc tttgttgtgg     5340

atctggatgg cagagctagg tgacggccgg gaaagtaacc agaagcttca ggaagagatt     5400

ataaagactt tggaacactt gcccattcct actaaaaata tgttggagga aagcaaagta     5460

cttccaatta ttcaacgctg gtctcagact aagactgctg tccctccgtt gagtgaagga     5520

gatgggtatt ctagtgagaa tacatcgcgt gctcatacac cactcaacac acctgatcct     5580

tccaccaagc tgagcacaga agctgacaca gacactccca agaaactaat gtttcgcaga     5640

ctgaaaatta taagtgaaaa tagcatggac agtgcaatct ctgatgcaac cagtgagcta     5700

gaaggcaagg atggcaaaga ggatcttgat caattagaaa atgtccctgt agaggaagag     5760

gaagaattgc agtcacaaca gctactccca caacagctgc ctgaatgcaa agttgatagt     5820

gaaaccaaca tagaagctag taagctacct acatctgaac cagaagctga cgctgaaata     5880

gagcccaaag agagcaacgg cacaaaacta gaagaaccta ttaatgaaga aacaccatcc     5940

caagatgaag aggagggtgt gtctgatgtg gagagtgaaa ggagccaaga acagccagat     6000

aaaacagtgg atataagtga tttggccacc aaactcctgg acagttggaa agacctaaag     6060

gaggtatatc gaattccaaa gaaaagtcaa actgaaaagg aaaacacaac aactgaacga     6120

ggaagggatg ctgttggctt cagagatcaa acacctgccc cgaagactcc taataggtca     6180

agagagagag acccagacaa gcaaactcaa aataaagaga aaaggaaacg aagaagctcc     6240

ctctcaccac cctcttctgc ctatgagcgg ggaacaaaaa ggccagatga cagatatgat     6300

acaccaactt ctaaaaagaa agtacgaatt aaagaccgca ataaactttc tacagaggaa     6360

cgccggaagt tgtttgagca agaggtggct caacgggagg ctcagaaaca acagcaacag     6420

atgcagaacc tgggaatgac atcaccactg ccctatgact ctcttggtta taatgccccg     6480

catcatccct ttgctggtta cccaccaggt tatcccatgc aggcctatgt ggatcccagc     6540

aaccctaatg ctggaaaggt gctcctgccc acacccagca tggacccagt gtgttctcct     6600

gctccttatg atcatgctca gcccttggtg ggacattcta cagaacccct ttctgcccct     6660

ccaccagtac cagtggtgcc acatgtggca gctcctgtgg aagtttccag ttcccagtat     6720

gtggcccaga gtgatggtgt agtacaccaa gactccagcg ttgctgtctt gccagtgccg     6780

gcccccggcc cagttcaggg acagaattat agtgtttggg attcaaacca acagtctgtc     6840

agtgtacagc agcagtactc tcctgcacag tctcaagcaa ccatatatta tcaaggacag     6900

acatgtccaa cagtctatgg tgtgacatca ccttattcac agacaactcc accaattgta     6960

cagagttatg cccagccaag tcttcagtat atccaggggc aacagatttt cacagctcat     7020

ccacaaggag tggtggtaca gccagccgca gcagtgacta caatagttgc accagggcag     7080

cctcagccct tgcagccatc tgaaatggtt gtgacaaata atctcttgga tctgccgccc     7140

ccctctcctc ccaaaccaaa aaccattgtc ttacctccca actggaagac agctcgagat     7200

ccagaaggga agatttatta ctaccatgtg atcacaaggc agactcagtg ggatcctcct     7260

acttgggaaa gcccaggaga tgatgccagc cttgagcatg aagctgagat ggacctggga     7320

actccaacat atgatgaaaa ccccatgaag gcctcgaaaa agcccaagac agcagaagca     7380

gacacctcca gtgaactagc aaagaaaagc aaagaagtat tcagaaaaga gatgtcccag     7440

ttcatcgtcc agtgcctgaa cccttaccgg aaacctgact gcaaagtggg aagaattacc     7500

acaactgaag actttaaaca tctggctcgc aagctgactc acggtgttat gaataaggag     7560

ctgaagtact gtaagaatcc tgaggacctg gagtgcaatg agaatgtgaa acacaaaacc     7620

aaggagtaca ttaagaagta catgcagaag tttggggctg tttacaaacc caaagaggac     7680

actgaattag agtga                                                      7695


<210>  2
<211>  2564
<212>  PRT
<213>  Homo sapiens

<400>  2

Met Lys Gln Leu Gln Pro Gln Pro Pro Pro Lys Met Gly Asp Phe Tyr 
1               5                   10                  15      


Asp Pro Glu His Pro Thr Pro Glu Glu Glu Glu Asn Glu Ala Lys Ile 
            20                  25                  30          


Glu Asn Val Gln Lys Thr Gly Phe Ile Lys Gly Pro Met Phe Lys Gly 
        35                  40                  45              


Val Ala Ser Ser Arg Phe Leu Pro Lys Gly Thr Lys Thr Lys Val Asn 
    50                  55                  60                  


Leu Glu Glu Gln Gly Arg Gln Lys Val Ser Phe Ser Phe Ser Leu Thr 
65                  70                  75                  80  


Lys Lys Thr Leu Gln Asn Arg Phe Leu Thr Ala Leu Gly Asn Glu Lys 
                85                  90                  95      


Gln Ser Asp Thr Pro Asn Pro Pro Ala Val Pro Leu Gln Val Asp Ser 
            100                 105                 110         


Thr Pro Lys Met Lys Met Glu Ile Gly Asp Thr Leu Ser Thr Ala Glu 
        115                 120                 125             


Glu Ser Ser Pro Pro Lys Ser Arg Val Glu Leu Gly Lys Ile His Phe 
    130                 135                 140                 


Lys Lys His Leu Leu His Val Thr Ser Arg Pro Leu Leu Ala Thr Thr 
145                 150                 155                 160 


Thr Ala Val Ala Ser Pro Pro Thr His Ala Ala Pro Leu Pro Ala Val 
                165                 170                 175     


Ile Ala Glu Ser Thr Thr Val Asp Ser Pro Pro Ser Ser Pro Pro Pro 
            180                 185                 190         


Pro Pro Pro Pro Ala Gln Ala Thr Thr Leu Ser Ser Pro Ala Pro Val 
        195                 200                 205             


Thr Glu Pro Val Ala Leu Pro His Thr Pro Ile Thr Val Leu Met Ala 
    210                 215                 220                 


Ala Pro Val Pro Leu Pro Val Asp Val Ala Val Arg Ser Leu Lys Glu 
225                 230                 235                 240 


Pro Pro Ile Ile Ile Val Pro Glu Ser Leu Glu Ala Asp Thr Lys Gln 
                245                 250                 255     


Asp Thr Ile Ser Asn Ser Leu Glu Glu His Val Thr Gln Ile Leu Asn 
            260                 265                 270         


Glu Gln Ala Asp Ile Ser Ser Lys Lys Glu Asp Ser His Ile Gly Lys 
        275                 280                 285             


Asp Glu Glu Ile Pro Asp Ser Ser Lys Ile Ser Leu Ser Cys Lys Lys 
    290                 295                 300                 


Thr Gly Ser Lys Lys Lys Ser Ser Gln Ser Glu Gly Ile Phe Leu Gly 
305                 310                 315                 320 


Ser Glu Ser Asp Glu Asp Ser Val Arg Thr Ser Ser Ser Gln Arg Ser 
                325                 330                 335     


His Asp Leu Lys Phe Ser Ala Ser Ile Glu Lys Glu Arg Asp Phe Lys 
            340                 345                 350         


Lys Ser Ser Ala Pro Leu Lys Ser Glu Asp Leu Gly Lys Pro Ser Arg 
        355                 360                 365             


Ser Lys Thr Asp Arg Asp Asp Lys Tyr Phe Ser Tyr Ser Lys Leu Glu 
    370                 375                 380                 


Arg Asp Thr Arg Tyr Val Ser Ser Arg Cys Arg Ser Glu Arg Glu Arg 
385                 390                 395                 400 


Arg Arg Ser Arg Ser His Ser Arg Ser Glu Arg Gly Ser Arg Thr Asn 
                405                 410                 415     


Leu Ser Tyr Ser Arg Ser Glu Arg Ser His Tyr Tyr Asp Ser Asp Arg 
            420                 425                 430         


Arg Tyr His Arg Ser Ser Pro Tyr Arg Glu Arg Thr Arg Tyr Ser Arg 
        435                 440                 445             


Pro Tyr Thr Asp Asn Arg Ala Arg Glu Ser Ser Asp Ser Glu Glu Glu 
    450                 455                 460                 


Tyr Lys Lys Thr Tyr Ser Arg Arg Thr Ser Ser His Ser Ser Ser Tyr 
465                 470                 475                 480 


Arg Asp Leu Arg Thr Ser Ser Tyr Ser Lys Ser Asp Arg Asp Cys Lys 
                485                 490                 495     


Thr Glu Thr Ser Tyr Leu Glu Met Glu Arg Arg Gly Lys Tyr Ser Ser 
            500                 505                 510         


Lys Leu Glu Arg Glu Ser Lys Arg Thr Ser Glu Asn Glu Ala Ile Lys 
        515                 520                 525             


Arg Cys Cys Ser Pro Pro Asn Glu Leu Gly Phe Arg Arg Gly Ser Ser 
    530                 535                 540                 


Tyr Ser Lys His Asp Ser Ser Ala Ser Arg Tyr Lys Ser Thr Leu Ser 
545                 550                 555                 560 


Lys Pro Ile Pro Lys Ser Asp Lys Phe Lys Asn Ser Phe Cys Cys Thr 
                565                 570                 575     


Glu Leu Asn Glu Glu Ile Lys Gln Ser His Ser Phe Ser Leu Gln Thr 
            580                 585                 590         


Pro Cys Ser Lys Gly Ser Glu Leu Arg Met Ile Asn Lys Asn Pro Glu 
        595                 600                 605             


Arg Glu Lys Ala Gly Ser Pro Ala Pro Ser Asn Arg Leu Asn Asp Ser 
    610                 615                 620                 


Pro Thr Leu Lys Lys Leu Asp Glu Leu Pro Ile Phe Lys Ser Glu Phe 
625                 630                 635                 640 


Ile Thr His Asp Ser His Asp Ser Ile Lys Glu Leu Asp Ser Leu Ser 
                645                 650                 655     


Lys Val Lys Asn Asp Gln Leu Arg Ser Phe Cys Pro Ile Glu Leu Asn 
            660                 665                 670         


Ile Asn Gly Ser Pro Gly Ala Glu Ser Asp Leu Ala Thr Phe Cys Thr 
        675                 680                 685             


Ser Lys Thr Asp Ala Val Leu Met Thr Ser Asp Asp Ser Val Thr Gly 
    690                 695                 700                 


Ser Glu Leu Ser Pro Leu Val Lys Ala Cys Met Leu Ser Ser Asn Gly 
705                 710                 715                 720 


Phe Gln Asn Ile Ser Arg Cys Lys Glu Lys Asp Leu Asp Asp Thr Cys 
                725                 730                 735     


Met Leu His Lys Lys Ser Glu Ser Pro Phe Arg Glu Thr Glu Pro Leu 
            740                 745                 750         


Val Ser Pro His Gln Asp Lys Leu Met Ser Met Pro Val Met Thr Val 
        755                 760                 765             


Asp Tyr Ser Lys Thr Val Val Lys Glu Pro Val Asp Thr Arg Val Ser 
    770                 775                 780                 


Cys Cys Lys Thr Lys Asp Ser Asp Ile Tyr Cys Thr Leu Asn Asp Ser 
785                 790                 795                 800 


Asn Pro Ser Leu Cys Asn Ser Glu Ala Glu Asn Ile Glu Pro Ser Val 
                805                 810                 815     


Met Lys Ile Ser Ser Asn Ser Phe Met Asn Val His Leu Glu Ser Lys 
            820                 825                 830         


Pro Val Ile Cys Asp Ser Arg Asn Leu Thr Asp His Ser Lys Phe Ala 
        835                 840                 845             


Cys Glu Glu Tyr Lys Gln Ser Ile Gly Ser Thr Ser Ser Ala Ser Val 
    850                 855                 860                 


Asn His Phe Asp Asp Leu Tyr Gln Pro Ile Gly Ser Ser Gly Ile Ala 
865                 870                 875                 880 


Ser Ser Leu Gln Ser Leu Pro Pro Gly Ile Lys Val Asp Ser Leu Thr 
                885                 890                 895     


Leu Leu Lys Cys Gly Glu Asn Thr Ser Pro Val Leu Asp Ala Val Leu 
            900                 905                 910         


Lys Ser Lys Lys Ser Ser Glu Phe Leu Lys His Ala Gly Lys Glu Thr 
        915                 920                 925             


Ile Val Glu Val Gly Ser Asp Leu Pro Asp Ser Gly Lys Gly Phe Ala 
    930                 935                 940                 


Ser Arg Glu Asn Arg Arg Asn Asn Gly Leu Ser Gly Lys Cys Leu Gln 
945                 950                 955                 960 


Glu Ala Gln Glu Glu Gly Asn Ser Ile Leu Pro Glu Arg Arg Gly Arg 
                965                 970                 975     


Pro Glu Ile Ser Leu Asp Glu Arg Gly Glu Gly Gly His Val His Thr 
            980                 985                 990         


Ser Asp Asp Ser Glu Val Val Phe  Ser Ser Cys Asp Leu  Asn Leu Thr 
        995                 1000                 1005             


Met Glu  Asp Ser Asp Gly Val  Thr Tyr Ala Leu Lys  Cys Asp Ser 
    1010                 1015                 1020             


Ser Gly  His Ala Pro Glu Ile  Val Ser Thr Val His  Glu Asp Tyr 
    1025                 1030                 1035             


Ser Gly  Ser Ser Glu Ser Ser  Asn Asp Glu Ser Asp  Ser Glu Asp 
    1040                 1045                 1050             


Thr Asp  Ser Asp Asp Ser Ser  Ile Pro Arg Asn Arg  Leu Gln Ser 
    1055                 1060                 1065             


Val Val  Val Val Pro Lys Asn  Ser Thr Leu Pro Met  Glu Glu Thr 
    1070                 1075                 1080             


Ser Pro  Cys Ser Ser Arg Ser  Ser Gln Ser Tyr Arg  His Tyr Ser 
    1085                 1090                 1095             


Asp His  Trp Glu Asp Glu Arg  Leu Glu Ser Arg Arg  His Leu Tyr 
    1100                 1105                 1110             


Glu Glu  Lys Phe Glu Ser Ile  Ala Ser Lys Ala Cys  Pro Gln Thr 
    1115                 1120                 1125             


Asp Lys  Phe Phe Leu His Lys  Gly Thr Glu Lys Asn  Pro Glu Ile 
    1130                 1135                 1140             


Ser Phe  Thr Gln Ser Ser Arg  Lys Gln Ile Asp Asn  Arg Leu Pro 
    1145                 1150                 1155             


Glu Leu  Ser His Pro Gln Ser  Asp Gly Val Asp Ser  Thr Ser His 
    1160                 1165                 1170             


Thr Asp  Val Lys Ser Asp Pro  Leu Gly His Pro Asn  Ser Glu Glu 
    1175                 1180                 1185             


Thr Val  Lys Ala Lys Ile Pro  Ser Arg Gln Gln Glu  Glu Leu Pro 
    1190                 1195                 1200             


Ile Tyr  Ser Ser Asp Phe Glu  Asp Val Pro Asn Lys  Ser Trp Gln 
    1205                 1210                 1215             


Gln Thr  Thr Phe Gln Asn Arg  Pro Asp Ser Arg Leu  Gly Lys Thr 
    1220                 1225                 1230             


Glu Leu  Ser Phe Ser Ser Ser  Cys Glu Ile Pro His  Val Asp Gly 
    1235                 1240                 1245             


Leu His  Ser Ser Glu Glu Leu  Arg Asn Leu Gly Trp  Asp Phe Ser 
    1250                 1255                 1260             


Gln Glu  Lys Pro Ser Thr Thr  Tyr Gln Gln Pro Asp  Ser Ser Tyr 
    1265                 1270                 1275             


Gly Ala  Cys Gly Gly His Lys  Tyr Gln Gln Asn Ala  Glu Gln Tyr 
    1280                 1285                 1290             


Gly Gly  Thr Arg Asp Tyr Trp  Gln Gly Asn Gly Tyr  Trp Asp Pro 
    1295                 1300                 1305             


Arg Ser  Gly Arg Pro Pro Gly  Thr Gly Val Val Tyr  Asp Arg Thr 
    1310                 1315                 1320             


Gln Gly  Gln Val Pro Asp Ser  Leu Thr Asp Asp Arg  Glu Glu Glu 
    1325                 1330                 1335             


Glu Asn  Trp Asp Gln Gln Asp  Gly Ser His Phe Ser  Asp Gln Ser 
    1340                 1345                 1350             


Asp Lys  Phe Leu Leu Ser Leu  Gln Lys Asp Lys Gly  Ser Val Gln 
    1355                 1360                 1365             


Ala Pro  Glu Ile Ser Ser Asn  Ser Ile Lys Asp Thr  Leu Ala Val 
    1370                 1375                 1380             


Asn Glu  Lys Lys Asp Phe Ser  Lys Asn Leu Glu Lys  Asn Asp Ile 
    1385                 1390                 1395             


Lys Asp  Arg Gly Pro Leu Lys  Lys Arg Arg Gln Glu  Ile Glu Ser 
    1400                 1405                 1410             


Asp Ser  Glu Ser Asp Gly Glu  Leu Gln Asp Arg Lys  Lys Val Arg 
    1415                 1420                 1425             


Val Glu  Val Glu Gln Gly Glu  Thr Ser Val Pro Pro  Gly Ser Ala 
    1430                 1435                 1440             


Leu Val  Gly Pro Ser Cys Val  Met Asp Asp Phe Arg  Asp Pro Gln 
    1445                 1450                 1455             


Arg Trp  Lys Glu Cys Ala Lys  Gln Gly Lys Met Pro  Cys Tyr Phe 
    1460                 1465                 1470             


Asp Leu  Ile Glu Glu Asn Val  Tyr Leu Thr Glu Arg  Lys Lys Asn 
    1475                 1480                 1485             


Lys Ser  His Arg Asp Ile Lys  Arg Met Gln Cys Glu  Cys Thr Pro 
    1490                 1495                 1500             


Leu Ser  Lys Asp Glu Arg Ala  Gln Gly Glu Ile Ala  Cys Gly Glu 
    1505                 1510                 1515             


Asp Cys  Leu Asn Arg Leu Leu  Met Ile Glu Cys Ser  Ser Arg Cys 
    1520                 1525                 1530             


Pro Asn  Gly Asp Tyr Cys Ser  Asn Arg Arg Phe Gln  Arg Lys Gln 
    1535                 1540                 1545             


His Ala  Asp Val Glu Val Ile  Leu Thr Glu Lys Lys  Gly Trp Gly 
    1550                 1555                 1560             


Leu Arg  Ala Ala Lys Asp Leu  Pro Ser Asn Thr Phe  Val Leu Glu 
    1565                 1570                 1575             


Tyr Cys  Gly Glu Val Leu Asp  His Lys Glu Phe Lys  Ala Arg Val 
    1580                 1585                 1590             


Lys Glu  Tyr Ala Arg Asn Lys  Asn Ile His Tyr Tyr  Phe Met Ala 
    1595                 1600                 1605             


Leu Lys  Asn Asp Glu Ile Ile  Asp Ala Thr Gln Lys  Gly Asn Cys 
    1610                 1615                 1620             


Ser Arg  Phe Met Asn His Ser  Cys Glu Pro Asn Cys  Glu Thr Gln 
    1625                 1630                 1635             


Lys Trp  Thr Val Asn Gly Gln  Leu Arg Val Gly Phe  Phe Thr Thr 
    1640                 1645                 1650             


Lys Leu  Val Pro Ser Gly Ser  Glu Leu Thr Phe Asp  Tyr Gln Phe 
    1655                 1660                 1665             


Gln Arg  Tyr Gly Lys Glu Ala  Gln Lys Cys Phe Cys  Gly Ser Ala 
    1670                 1675                 1680             


Asn Cys  Arg Gly Tyr Leu Gly  Gly Glu Asn Arg Val  Ser Ile Arg 
    1685                 1690                 1695             


Ala Ala  Gly Gly Lys Met Lys  Lys Glu Arg Ser Arg  Lys Lys Asp 
    1700                 1705                 1710             


Ser Val  Asp Gly Glu Leu Glu  Ala Leu Met Glu Asn  Gly Glu Gly 
    1715                 1720                 1725             


Leu Ser  Asp Lys Asn Gln Val  Leu Ser Leu Ser Arg  Leu Met Val 
    1730                 1735                 1740             


Arg Ile  Glu Thr Leu Glu Gln  Lys Leu Thr Cys Leu  Glu Leu Ile 
    1745                 1750                 1755             


Gln Asn  Thr His Ser Gln Ser  Cys Leu Lys Ser Phe  Leu Glu Arg 
    1760                 1765                 1770             


His Gly  Leu Ser Leu Leu Trp  Ile Trp Met Ala Glu  Leu Gly Asp 
    1775                 1780                 1785             


Gly Arg  Glu Ser Asn Gln Lys  Leu Gln Glu Glu Ile  Ile Lys Thr 
    1790                 1795                 1800             


Leu Glu  His Leu Pro Ile Pro  Thr Lys Asn Met Leu  Glu Glu Ser 
    1805                 1810                 1815             


Lys Val  Leu Pro Ile Ile Gln  Arg Trp Ser Gln Thr  Lys Thr Ala 
    1820                 1825                 1830             


Val Pro  Pro Leu Ser Glu Gly  Asp Gly Tyr Ser Ser  Glu Asn Thr 
    1835                 1840                 1845             


Ser Arg  Ala His Thr Pro Leu  Asn Thr Pro Asp Pro  Ser Thr Lys 
    1850                 1855                 1860             


Leu Ser  Thr Glu Ala Asp Thr  Asp Thr Pro Lys Lys  Leu Met Phe 
    1865                 1870                 1875             


Arg Arg  Leu Lys Ile Ile Ser  Glu Asn Ser Met Asp  Ser Ala Ile 
    1880                 1885                 1890             


Ser Asp  Ala Thr Ser Glu Leu  Glu Gly Lys Asp Gly  Lys Glu Asp 
    1895                 1900                 1905             


Leu Asp  Gln Leu Glu Asn Val  Pro Val Glu Glu Glu  Glu Glu Leu 
    1910                 1915                 1920             


Gln Ser  Gln Gln Leu Leu Pro  Gln Gln Leu Pro Glu  Cys Lys Val 
    1925                 1930                 1935             


Asp Ser  Glu Thr Asn Ile Glu  Ala Ser Lys Leu Pro  Thr Ser Glu 
    1940                 1945                 1950             


Pro Glu  Ala Asp Ala Glu Ile  Glu Pro Lys Glu Ser  Asn Gly Thr 
    1955                 1960                 1965             


Lys Leu  Glu Glu Pro Ile Asn  Glu Glu Thr Pro Ser  Gln Asp Glu 
    1970                 1975                 1980             


Glu Glu  Gly Val Ser Asp Val  Glu Ser Glu Arg Ser  Gln Glu Gln 
    1985                 1990                 1995             


Pro Asp  Lys Thr Val Asp Ile  Ser Asp Leu Ala Thr  Lys Leu Leu 
    2000                 2005                 2010             


Asp Ser  Trp Lys Asp Leu Lys  Glu Val Tyr Arg Ile  Pro Lys Lys 
    2015                 2020                 2025             


Ser Gln  Thr Glu Lys Glu Asn  Thr Thr Thr Glu Arg  Gly Arg Asp 
    2030                 2035                 2040             


Ala Val  Gly Phe Arg Asp Gln  Thr Pro Ala Pro Lys  Thr Pro Asn 
    2045                 2050                 2055             


Arg Ser  Arg Glu Arg Asp Pro  Asp Lys Gln Thr Gln  Asn Lys Glu 
    2060                 2065                 2070             


Lys Arg  Lys Arg Arg Ser Ser  Leu Ser Pro Pro Ser  Ser Ala Tyr 
    2075                 2080                 2085             


Glu Arg  Gly Thr Lys Arg Pro  Asp Asp Arg Tyr Asp  Thr Pro Thr 
    2090                 2095                 2100             


Ser Lys  Lys Lys Val Arg Ile  Lys Asp Arg Asn Lys  Leu Ser Thr 
    2105                 2110                 2115             


Glu Glu  Arg Arg Lys Leu Phe  Glu Gln Glu Val Ala  Gln Arg Glu 
    2120                 2125                 2130             


Ala Gln  Lys Gln Gln Gln Gln  Met Gln Asn Leu Gly  Met Thr Ser 
    2135                 2140                 2145             


Pro Leu  Pro Tyr Asp Ser Leu  Gly Tyr Asn Ala Pro  His His Pro 
    2150                 2155                 2160             


Phe Ala  Gly Tyr Pro Pro Gly  Tyr Pro Met Gln Ala  Tyr Val Asp 
    2165                 2170                 2175             


Pro Ser  Asn Pro Asn Ala Gly  Lys Val Leu Leu Pro  Thr Pro Ser 
    2180                 2185                 2190             


Met Asp  Pro Val Cys Ser Pro  Ala Pro Tyr Asp His  Ala Gln Pro 
    2195                 2200                 2205             


Leu Val  Gly His Ser Thr Glu  Pro Leu Ser Ala Pro  Pro Pro Val 
    2210                 2215                 2220             


Pro Val  Val Pro His Val Ala  Ala Pro Val Glu Val  Ser Ser Ser 
    2225                 2230                 2235             


Gln Tyr  Val Ala Gln Ser Asp  Gly Val Val His Gln  Asp Ser Ser 
    2240                 2245                 2250             


Val Ala  Val Leu Pro Val Pro  Ala Pro Gly Pro Val  Gln Gly Gln 
    2255                 2260                 2265             


Asn Tyr  Ser Val Trp Asp Ser  Asn Gln Gln Ser Val  Ser Val Gln 
    2270                 2275                 2280             


Gln Gln  Tyr Ser Pro Ala Gln  Ser Gln Ala Thr Ile  Tyr Tyr Gln 
    2285                 2290                 2295             


Gly Gln  Thr Cys Pro Thr Val  Tyr Gly Val Thr Ser  Pro Tyr Ser 
    2300                 2305                 2310             


Gln Thr  Thr Pro Pro Ile Val  Gln Ser Tyr Ala Gln  Pro Ser Leu 
    2315                 2320                 2325             


Gln Tyr  Ile Gln Gly Gln Gln  Ile Phe Thr Ala His  Pro Gln Gly 
    2330                 2335                 2340             


Val Val  Val Gln Pro Ala Ala  Ala Val Thr Thr Ile  Val Ala Pro 
    2345                 2350                 2355             


Gly Gln  Pro Gln Pro Leu Gln  Pro Ser Glu Met Val  Val Thr Asn 
    2360                 2365                 2370             


Asn Leu  Leu Asp Leu Pro Pro  Pro Ser Pro Pro Lys  Pro Lys Thr 
    2375                 2380                 2385             


Ile Val  Leu Pro Pro Asn Trp  Lys Thr Ala Arg Asp  Pro Glu Gly 
    2390                 2395                 2400             


Lys Ile  Tyr Tyr Tyr His Val  Ile Thr Arg Gln Thr  Gln Trp Asp 
    2405                 2410                 2415             


Pro Pro  Thr Trp Glu Ser Pro  Gly Asp Asp Ala Ser  Leu Glu His 
    2420                 2425                 2430             


Glu Ala  Glu Met Asp Leu Gly  Thr Pro Thr Tyr Asp  Glu Asn Pro 
    2435                 2440                 2445             


Met Lys  Ala Ser Lys Lys Pro  Lys Thr Ala Glu Ala  Asp Thr Ser 
    2450                 2455                 2460             


Ser Glu  Leu Ala Lys Lys Ser  Lys Glu Val Phe Arg  Lys Glu Met 
    2465                 2470                 2475             


Ser Gln  Phe Ile Val Gln Cys  Leu Asn Pro Tyr Arg  Lys Pro Asp 
    2480                 2485                 2490             


Cys Lys  Val Gly Arg Ile Thr  Thr Thr Glu Asp Phe  Lys His Leu 
    2495                 2500                 2505             


Ala Arg  Lys Leu Thr His Gly  Val Met Asn Lys Glu  Leu Lys Tyr 
    2510                 2515                 2520             


Cys Lys  Asn Pro Glu Asp Leu  Glu Cys Asn Glu Asn  Val Lys His 
    2525                 2530                 2535             


Lys Thr  Lys Glu Tyr Ile Lys  Lys Tyr Met Gln Lys  Phe Gly Ala 
    2540                 2545                 2550             


Val Tyr  Lys Pro Lys Glu Asp  Thr Glu Leu Glu 
    2555                 2560                 


<210>  3
<211>  1941
<212>  DNA
<213>  Homo sapiens

<400>  3
atgagcttcc tgagccgaca gcagccgccg ccaccccgcc gcgccggggc ggcctgcacc       60

ttgcggcaga agctgatctt ctcgccctgc agcgactgtg aggaggagga agaagaggag      120

gaggaggagg gcagcggcca cagcaccggg gaggactcgg cctttcaaga gcccgactcg      180

ccgctgccgc ccgcgcggag ccccacggag cccgggcccg agcgccgccg ctcgcccggg      240

ccggcccccg gcagccccgg cgagctggag gaggacctgt tgctgcccgg cgcctgcccg      300

ggcgcggacg aggcgggcgg tggggcggag ggcgactcgt gggaggagga gggcttcggc      360

tcctcgtcgc cggtcaagtc gccggcggcc ccctacttcc tgggtagctc tttctcgccg      420

gtgcgctgcg gcggcccagg agatgcgtcg ccgcggggtt gcggggcgcg ccgggcgggc      480

gaaggccgcc gctcgccgcg gccggaccac ccgggcaccc cgccacacaa gaccttccgc      540

aagctgcgac tcttcgacac cccgcacacg cccaagagtt tgctctccaa agctcgggga      600

attgattcca gctctgttaa actccggggt agttctctct tcatggatac agaaaaatca      660

ggaaaaaggg aatttgatgt gcgacagact cctcaagtga atattaatcc ttttactccg      720

gattctttgt tgcttcattc ctcaggacag tgtcgtcgta gaaagagaac gtattggaat      780

gattcctgtg gtgaagacat ggaagccagt gattatgagc ttgaagatga aacaagacct      840

gctaagagaa ttacaattac tgaaagcaat atgaagtccc ggtatacaac agaatttcat      900

gagctagaga aaatcggctc tggagaattt ggttctgtat ttaagtgtgt gaagaggctg      960

gatggatgca tttatgccat taagcgatca aaaaagccat tggcgggctc tgttgatgag     1020

cagaacgctt tgagagaagt atatgctcat gcagtgcttg gacagcattc tcatgtagtt     1080

cgatatttct ctgcgtgggc agaagatgat catatgctta tacagaatga atattgtaat     1140

ggtggaagtt tagctgatgc tataagtgaa aactacagaa tcatgagtta ctttaaagaa     1200

gcagagttga aggatctcct tttgcaagtt ggccgaggct tgaggtatat tcattcaatg     1260

tctttggttc acatggatat aaaacctagt aatattttca tatctcgaac ctcaatccca     1320

aatgctgcct ctgaagaagg agacgaagat gattgggcat ccaacaaagt tatgtttaaa     1380

ataggtgatc ttgggcatgt aacaaggatc tccagtccac aagttgaaga gggcgatagt     1440

cgttttcttg caaatgaagt tttacaggag aattataccc atctaccaaa agcagatatt     1500

tttgcgcttg ccctcacagt ggtatgtgct gctggtgctg aacctcttcc gagaaatgga     1560

gatcaatggc atgaaatcag acagggtaga ttacctcgga taccacaagt gctttcccaa     1620

gaatttacag agttgctaaa agttatgatt catccagatc cagagagaag accttcagca     1680

atggcactgg taaagcattc agtattgctg tccgcttcta gaaagagtgc agaacaatta     1740

cgaatagaat tgaatgccga aaagttcaaa aattcacttt tacaaaaaga actcaagaaa     1800

gcacagatgg caaaagctgc agctgaggaa agagcactct tcactgaccg gatggccact     1860

aggtccacca cccagagtaa tagaacatct cgacttattg gaaagaaaat gaaccgctct     1920

gtcagcctta ctatatactg a                                               1941


<210>  4
<211>  3374
<212>  DNA
<213>  Homo sapiens

<400>  4
ctgagactgg acctgaggag acctcagcct cggtgctcgg gccgccccgc ctctgccgga       60

aagtccgcgc cgccgctgcc gccaccgtcc gcagcccgag cgccccggag ccgcaggccg      120

ccgccgcgca gagacgccgc ggctgcgact aggcgcgccc agccgcacgt ggcggacccg      180

cccccaggcc cgcagtgtcc tggaccccgc aggcctccgc tctcctgtcc tcggccccgt      240

ccccagggcc gcgatgagct tcctgagccg acagcagccg ccgccacccc gccgcgccgg      300

ggcggcctgc accttgcggc agaagctgat cttctcgccc tgcagcgact gtgaggagga      360

ggaagaagag gaggaggagg agggcagcgg ccacagcacc ggggaggact cggcctttca      420

agagcccgac tcgccgctgc cgcccgcgcg gagccccacg gagcccgggc ccgagcgccg      480

ccgctcgccc gggccggccc ccggcagccc cggcgagctg gaggaggacc tgttgctgcc      540

cggcgcctgc ccgggcgcgg acgaggcggg cggtggggcg gagggcgact cgtgggagga      600

ggagggcttc ggctcctcgt cgccggtcaa gtcgccggcg gccccctact tcctgggtag      660

ctctttctcg ccggtgcgct gcggcggccc aggagatgcg tcgccgcggg gttgcggggc      720

gcgccgggcg ggcgaaggcc gccgctcgcc gcggccggac cacccgggca ccccgccaca      780

caagaccttc cgcaagctgc gactcttcga caccccgcac acgcccaaga gtttgctctc      840

caaagctcgg ggaattgatt ccagctctgt taaactccgg ggtagttctc tcttcatgga      900

tacagaaaaa tcaggaaaaa gggaatttga tgtgcgacag actcctcaag tgaatattaa      960

tccttttact ccggattctt tgttgcttca ttcctcagga cagtgtcgtc gtagaaagag     1020

aacgtattgg aatgattcct gtggtgaaga catggaagcc agtgattatg agcttgaaga     1080

tgaaacaaga cctgctaaga gaattacaat tactgaaagc aatatgaagt cccggtatac     1140

aacagaattt catgagctag agaaaatcgg ctctggagaa tttggttctg tatttaagtg     1200

tgtgaagagg ctggatggat gcatttatgc cattaagcga tcaaaaaagc cattggcggg     1260

ctctgttgat gagcagaacg ctttgagaga agtatatgct catgcagtgc ttggacagca     1320

ttctcatgta gttcgatatt tctctgcgtg ggcagaagat gatcatatgc ttatacagaa     1380

tgaatattgt aatggtggaa gtttagctga tgctataagt gaaaactaca gaatcatgag     1440

ttactttaaa gaagcagagt tgaaggatct ccttttgcaa gttggccgag gcttgaggta     1500

tattcattca atgtctttgg ttcacatgga tataaaacct agtaatattt tcatatctcg     1560

aacctcaatc ccaaatgctg cctctgaaga aggagacgaa gatgattggg catccaacaa     1620

agttatgttt aaaataggtg atcttgggca tgtaacaagg atctccagtc cacaagttga     1680

agagggcgat agtcgttttc ttgcaaatga agttttacag gagaattata cccatctacc     1740

aaaagcagat atttttgcgc ttgccctcac agtggtatgt gctgctggtg ctgaacctct     1800

tccgagaaat ggagatcaat ggcatgaaat cagacagggt agattacctc ggataccaca     1860

agtgctttcc caagaattta cagagttgct aaaagttatg attcatccag atccagagag     1920

aagaccttca gcaatggcac tggtaaagca ttcagtattg ctgtccgctt ctagaaagag     1980

tgcagaacaa ttacgaatag aattgaatgc cgaaaagttc aaaaattcac ttttacaaaa     2040

agaactcaag aaagcacaga tggcaaaagc tgcagctgag gaaagagcac tcttcactga     2100

ccggatggcc actaggtcca ccacccagag taatagaaca tctcgactta ttggaaagaa     2160

aatgaaccgc tctgtcagcc ttactatata ctgagctact cctttcccac ctccccctga     2220

acactgtgac aagaggaagc taggttgaaa tcactgatag aatccagttt gcaattactt     2280

tctcgattgg tgtcagtagt tttactgatt aggactttta ttgtgaatta cagttgaaag     2340

ctgtattttg atgattgcta tgtcaggctt tcatctaatc ttaccagtct gtcttctgta     2400

ggatgtgtca ctgttggatg ttacaccagc ctttccaggg ttaaccactg tggtggtgtg     2460

ctgcttatag tttgctgttg cattgtaata aaaggtgtct ttccctgtag tgacctgtaa     2520

aaagtactca agggctttat tacagacata ccctcccttt gaaaagggac atgctaaaag     2580

actcattact actcagcctt caatgtacct gtgtgtccat cttatatttc tttttttttt     2640

aattgtgaat tagacttgta tatcccactg ggagcacttt gtaggcattg catgaaccat     2700

gggatgatga ttctgtggag gtattgcctt gtgaatttgc tgctatttta gttttgtctt     2760

tgctgtaaac ttgtagcatt aaacaatcat tgttgttaat aggtcttctt tttgaaacaa     2820

ttatgtgaaa tgtatagctg cttttgatga aaagcagcta tttgcctttt tttttttttc     2880

ctttgaactt tgaagctagt gcattggaaa aatgcaccct ttccctcctt tggaatgctg     2940

tattaatgta gtataataat tactggtttt gtaacttgtt ctggtaatgt ccttcccgga     3000

ctctttttaa atgtctcccc ctaagtttta tacttgattg tattattagt ctgtttttaa     3060

atgttttgcc cggtttttct cttcaatatt tgtgtatata aaccgatctt cgtgatactg     3120

tacatagctg tttgaaatgc cagaatgact tctgacattc caagtttttc acaaaatata     3180

ttttatctgt gattagccat ttgactaata atactggcta acagatgttg aaaaaaattg     3240

tctgtttgtt ttctcattaa ttttggtcta aaacatgttt gcacttgtct ttgacttgtg     3300

ttttattaac attgattggc atattaaaag tcactctgag cttaccttaa ttgtctaaaa     3360

aaaaaaaaaa aaaa                                                       3374


<210>  5
<211>  646
<212>  PRT
<213>  Homo sapiens

<400>  5

Met Ser Phe Leu Ser Arg Gln Gln Pro Pro Pro Pro Arg Arg Ala Gly 
1               5                   10                  15      


Ala Ala Cys Thr Leu Arg Gln Lys Leu Ile Phe Ser Pro Cys Ser Asp 
            20                  25                  30          


Cys Glu Glu Glu Glu Glu Glu Glu Glu Glu Glu Gly Ser Gly His Ser 
        35                  40                  45              


Thr Gly Glu Asp Ser Ala Phe Gln Glu Pro Asp Ser Pro Leu Pro Pro 
    50                  55                  60                  


Ala Arg Ser Pro Thr Glu Pro Gly Pro Glu Arg Arg Arg Ser Pro Gly 
65                  70                  75                  80  


Pro Ala Pro Gly Ser Pro Gly Glu Leu Glu Glu Asp Leu Leu Leu Pro 
                85                  90                  95      


Gly Ala Cys Pro Gly Ala Asp Glu Ala Gly Gly Gly Ala Glu Gly Asp 
            100                 105                 110         


Ser Trp Glu Glu Glu Gly Phe Gly Ser Ser Ser Pro Val Lys Ser Pro 
        115                 120                 125             


Ala Ala Pro Tyr Phe Leu Gly Ser Ser Phe Ser Pro Val Arg Cys Gly 
    130                 135                 140                 


Gly Pro Gly Asp Ala Ser Pro Arg Gly Cys Gly Ala Arg Arg Ala Gly 
145                 150                 155                 160 


Glu Gly Arg Arg Ser Pro Arg Pro Asp His Pro Gly Thr Pro Pro His 
                165                 170                 175     


Lys Thr Phe Arg Lys Leu Arg Leu Phe Asp Thr Pro His Thr Pro Lys 
            180                 185                 190         


Ser Leu Leu Ser Lys Ala Arg Gly Ile Asp Ser Ser Ser Val Lys Leu 
        195                 200                 205             


Arg Gly Ser Ser Leu Phe Met Asp Thr Glu Lys Ser Gly Lys Arg Glu 
    210                 215                 220                 


Phe Asp Val Arg Gln Thr Pro Gln Val Asn Ile Asn Pro Phe Thr Pro 
225                 230                 235                 240 


Asp Ser Leu Leu Leu His Ser Ser Gly Gln Cys Arg Arg Arg Lys Arg 
                245                 250                 255     


Thr Tyr Trp Asn Asp Ser Cys Gly Glu Asp Met Glu Ala Ser Asp Tyr 
            260                 265                 270         


Glu Leu Glu Asp Glu Thr Arg Pro Ala Lys Arg Ile Thr Ile Thr Glu 
        275                 280                 285             


Ser Asn Met Lys Ser Arg Tyr Thr Thr Glu Phe His Glu Leu Glu Lys 
    290                 295                 300                 


Ile Gly Ser Gly Glu Phe Gly Ser Val Phe Lys Cys Val Lys Arg Leu 
305                 310                 315                 320 


Asp Gly Cys Ile Tyr Ala Ile Lys Arg Ser Lys Lys Pro Leu Ala Gly 
                325                 330                 335     


Ser Val Asp Glu Gln Asn Ala Leu Arg Glu Val Tyr Ala His Ala Val 
            340                 345                 350         


Leu Gly Gln His Ser His Val Val Arg Tyr Phe Ser Ala Trp Ala Glu 
        355                 360                 365             


Asp Asp His Met Leu Ile Gln Asn Glu Tyr Cys Asn Gly Gly Ser Leu 
    370                 375                 380                 


Ala Asp Ala Ile Ser Glu Asn Tyr Arg Ile Met Ser Tyr Phe Lys Glu 
385                 390                 395                 400 


Ala Glu Leu Lys Asp Leu Leu Leu Gln Val Gly Arg Gly Leu Arg Tyr 
                405                 410                 415     


Ile His Ser Met Ser Leu Val His Met Asp Ile Lys Pro Ser Asn Ile 
            420                 425                 430         


Phe Ile Ser Arg Thr Ser Ile Pro Asn Ala Ala Ser Glu Glu Gly Asp 
        435                 440                 445             


Glu Asp Asp Trp Ala Ser Asn Lys Val Met Phe Lys Ile Gly Asp Leu 
    450                 455                 460                 


Gly His Val Thr Arg Ile Ser Ser Pro Gln Val Glu Glu Gly Asp Ser 
465                 470                 475                 480 


Arg Phe Leu Ala Asn Glu Val Leu Gln Glu Asn Tyr Thr His Leu Pro 
                485                 490                 495     


Lys Ala Asp Ile Phe Ala Leu Ala Leu Thr Val Val Cys Ala Ala Gly 
            500                 505                 510         


Ala Glu Pro Leu Pro Arg Asn Gly Asp Gln Trp His Glu Ile Arg Gln 
        515                 520                 525             


Gly Arg Leu Pro Arg Ile Pro Gln Val Leu Ser Gln Glu Phe Thr Glu 
    530                 535                 540                 


Leu Leu Lys Val Met Ile His Pro Asp Pro Glu Arg Arg Pro Ser Ala 
545                 550                 555                 560 


Met Ala Leu Val Lys His Ser Val Leu Leu Ser Ala Ser Arg Lys Ser 
                565                 570                 575     


Ala Glu Gln Leu Arg Ile Glu Leu Asn Ala Glu Lys Phe Lys Asn Ser 
            580                 585                 590         


Leu Leu Gln Lys Glu Leu Lys Lys Ala Gln Met Ala Lys Ala Ala Ala 
        595                 600                 605             


Glu Glu Arg Ala Leu Phe Thr Asp Arg Met Ala Thr Arg Ser Thr Thr 
    610                 615                 620                 


Gln Ser Asn Arg Thr Ser Arg Leu Ile Gly Lys Lys Met Asn Arg Ser 
625                 630                 635                 640 


Val Ser Leu Thr Ile Tyr 
                645     


<210>  6
<211>  3234
<212>  DNA
<213>  Homo sapiens

<400>  6
atgtaactga acaatgggcc tcgtctggaa cttcatctta caaaggggcc gatcggcccg       60

tccgggtggc caaggatttg ccgcccgttg agtccgggcc gccccgagcg tgtcagcccc      120

gagtgcggca ccgataacgc ggttcgcgag gatgctggag ggtgccggcc cggccacctg      180

acactcccga gccataggat gccttttaaa cgcggcgatc gggcctgtaa tttgggcggc      240

gcgggcagaa ggagtttaaa gaaaaataat tgtcccgccc tgatcgtgtc gtgtcgtgtg      300

gcgtggatgg gggaaaggtc tggggcatgc agggagacta cgcttggact tgggagtaaa      360

ggctggcctt ccaagcattt acagtcctac agactcatcc taagtccagg cagtactgag      420

gcctgtttct ggacaaggtc ttggcccagc atttgttttt atcgtgggtt tgcggtgccc      480

agagtttggc cggcctccgt gtgattagga acatcctacc gtagataagg tatcttaaag      540

aaggaggtgt tcagcacctg tgttttgaaa ggccttcgag tactgcgcag atgaccactt      600

ttaaaactgc agattttaaa gctgatactt ccagagatta agacaagcct cgcatttgta      660

aggttaacag ggaagatgca ccttttaaaa gtttgctctc caaagctcgg ggaattgatt      720

ccagctctgt taaactccgg ggtagttctc tcttcatgga tacagaaaaa tcaggaaaaa      780

gggaatttga tgtgcgacag actcctcaag tgaatattaa tccttttact ccggattctt      840

tgttgcttca ttcctcagga cagtgtcgtc gtagaaagag aacgtattgg aatgattcct      900

gtggtgaaga catggaagcc agtgattatg agcttgaaga tgaaacaaga cctgctaaga      960

gaattacaat tactgaaagc aatatgaagt cccggtatac aacagaattt catgagctag     1020

agaaaatcgg ctctggagaa tttggttctg tatttaagtg tgtgaagagg ctggatggat     1080

gcatttatgc cattaagcga tcaaaaaagc cattggcggg ctctgttgat gagcagaacg     1140

ctttgagaga agtatatgct catgcagtgc ttggacagca ttctcatgta gttcgatatt     1200

tctctgcgtg ggcagaagat gatcatatgc ttatacagaa tgaatattgt aatggtggaa     1260

gtttagctga tgctataagt gaaaactaca gaatcatgag ttactttaaa gaagcagagt     1320

tgaaggatct ccttttgcaa gttggccgag gcttgaggta tattcattca atgtctttgg     1380

ttcacatgga tataaaacct agtaatattt tcatatctcg aacctcaatc ccaaatgctg     1440

cctctgaaga aggagacgaa gatgattggg catccaacaa agttatgttt aaaataggtg     1500

atcttgggca tgtaacaagg atctccagtc cacaagttga agagggcgat agtcgttttc     1560

ttgcaaatga agttttacag gagaattata cccatctacc aaaagcagat atttttgcgc     1620

ttgccctcac agtggtatgt gctgctggtg ctgaacctct tccgagaaat ggagatcaat     1680

ggcatgaaat cagacagggt agattacctc ggataccaca agtgctttcc caagaattta     1740

cagagttgct aaaagttatg attcatccag atccagagag aagaccttca gcaatggcac     1800

tggtaaagca ttcagtattg ctgtccgctt ctagaaagag tgcagaacaa ttacgaatag     1860

aattgaatgc cgaaaagttc aaaaattcac ttttacaaaa agaactcaag aaagcacaga     1920

tggcaaaagc tgcagctgag gaaagagcac tcttcactga ccggatggcc actaggtcca     1980

ccacccagag taatagaaca tctcgactta ttggaaagaa aatgaaccgc tctgtcagcc     2040

ttactatata ctgagctact cctttcccac ctccccctga acactgtgac aagaggaagc     2100

taggttgaaa tcactgatag aatccagttt gcaattactt tctcgattgg tgtcagtagt     2160

tttactgatt aggactttta ttgtgaatta cagttgaaag ctgtattttg atgattgcta     2220

tgtcaggctt tcatctaatc ttaccagtct gtcttctgta ggatgtgtca ctgttggatg     2280

ttacaccagc ctttccaggg ttaaccactg tggtggtgtg ctgcttatag tttgctgttg     2340

cattgtaata aaaggtgtct ttccctgtag tgacctgtaa aaagtactca agggctttat     2400

tacagacata ccctcccttt gaaaagggac atgctaaaag actcattact actcagcctt     2460

caatgtacct gtgtgtccat cttatatttc tttttttttt aattgtgaat tagacttgta     2520

tatcccactg ggagcacttt gtaggcattg catgaaccat gggatgatga ttctgtggag     2580

gtattgcctt gtgaatttgc tgctatttta gttttgtctt tgctgtaaac ttgtagcatt     2640

aaacaatcat tgttgttaat aggtcttctt tttgaaacaa ttatgtgaaa tgtatagctg     2700

cttttgatga aaagcagcta tttgcctttt tttttttttc ctttgaactt tgaagctagt     2760

gcattggaaa aatgcaccct ttccctcctt tggaatgctg tattaatgta gtataataat     2820

tactggtttt gtaacttgtt ctggtaatgt ccttcccgga ctctttttaa atgtctcccc     2880

ctaagtttta tacttgattg tattattagt ctgtttttaa atgttttgcc cggtttttct     2940

cttcaatatt tgtgtatata aaccgatctt cgtgatactg tacatagctg tttgaaatgc     3000

cagaatgact tctgacattc caagtttttc acaaaatata ttttatctgt gattagccat     3060

ttgactaata atactggcta acagatgttg aaaaaaattg tctgtttgtt ttctcattaa     3120

ttttggtcta aaacatgttt gcacttgtct ttgacttgtg ttttattaac attgattggc     3180

atattaaaag tcactctgag cttaccttaa ttgtctaaaa aaaaaaaaaa aaaa           3234


<210>  7
<211>  432
<212>  PRT
<213>  Homo sapiens

<400>  7

Met Asp Thr Glu Lys Ser Gly Lys Arg Glu Phe Asp Val Arg Gln Thr 
1               5                   10                  15      


Pro Gln Val Asn Ile Asn Pro Phe Thr Pro Asp Ser Leu Leu Leu His 
            20                  25                  30          


Ser Ser Gly Gln Cys Arg Arg Arg Lys Arg Thr Tyr Trp Asn Asp Ser 
        35                  40                  45              


Cys Gly Glu Asp Met Glu Ala Ser Asp Tyr Glu Leu Glu Asp Glu Thr 
    50                  55                  60                  


Arg Pro Ala Lys Arg Ile Thr Ile Thr Glu Ser Asn Met Lys Ser Arg 
65                  70                  75                  80  


Tyr Thr Thr Glu Phe His Glu Leu Glu Lys Ile Gly Ser Gly Glu Phe 
                85                  90                  95      


Gly Ser Val Phe Lys Cys Val Lys Arg Leu Asp Gly Cys Ile Tyr Ala 
            100                 105                 110         


Ile Lys Arg Ser Lys Lys Pro Leu Ala Gly Ser Val Asp Glu Gln Asn 
        115                 120                 125             


Ala Leu Arg Glu Val Tyr Ala His Ala Val Leu Gly Gln His Ser His 
    130                 135                 140                 


Val Val Arg Tyr Phe Ser Ala Trp Ala Glu Asp Asp His Met Leu Ile 
145                 150                 155                 160 


Gln Asn Glu Tyr Cys Asn Gly Gly Ser Leu Ala Asp Ala Ile Ser Glu 
                165                 170                 175     


Asn Tyr Arg Ile Met Ser Tyr Phe Lys Glu Ala Glu Leu Lys Asp Leu 
            180                 185                 190         


Leu Leu Gln Val Gly Arg Gly Leu Arg Tyr Ile His Ser Met Ser Leu 
        195                 200                 205             


Val His Met Asp Ile Lys Pro Ser Asn Ile Phe Ile Ser Arg Thr Ser 
    210                 215                 220                 


Ile Pro Asn Ala Ala Ser Glu Glu Gly Asp Glu Asp Asp Trp Ala Ser 
225                 230                 235                 240 


Asn Lys Val Met Phe Lys Ile Gly Asp Leu Gly His Val Thr Arg Ile 
                245                 250                 255     


Ser Ser Pro Gln Val Glu Glu Gly Asp Ser Arg Phe Leu Ala Asn Glu 
            260                 265                 270         


Val Leu Gln Glu Asn Tyr Thr His Leu Pro Lys Ala Asp Ile Phe Ala 
        275                 280                 285             


Leu Ala Leu Thr Val Val Cys Ala Ala Gly Ala Glu Pro Leu Pro Arg 
    290                 295                 300                 


Asn Gly Asp Gln Trp His Glu Ile Arg Gln Gly Arg Leu Pro Arg Ile 
305                 310                 315                 320 


Pro Gln Val Leu Ser Gln Glu Phe Thr Glu Leu Leu Lys Val Met Ile 
                325                 330                 335     


His Pro Asp Pro Glu Arg Arg Pro Ser Ala Met Ala Leu Val Lys His 
            340                 345                 350         


Ser Val Leu Leu Ser Ala Ser Arg Lys Ser Ala Glu Gln Leu Arg Ile 
        355                 360                 365             


Glu Leu Asn Ala Glu Lys Phe Lys Asn Ser Leu Leu Gln Lys Glu Leu 
    370                 375                 380                 


Lys Lys Ala Gln Met Ala Lys Ala Ala Ala Glu Glu Arg Ala Leu Phe 
385                 390                 395                 400 


Thr Asp Arg Met Ala Thr Arg Ser Thr Thr Gln Ser Asn Arg Thr Ser 
                405                 410                 415     


Arg Leu Ile Gly Lys Lys Met Asn Arg Ser Val Ser Leu Thr Ile Tyr 
            420                 425                 430         


<210>  8
<211>  1431
<212>  DNA
<213>  Homo sapiens

<400>  8
atggcagtgc cctttgtgga agactgggac ttggtgcaaa ccctgggaga aggtgcctat       60

ggagaagttc aacttgctgt gaatagagta actgaagaag cagtcgcagt gaagattgta      120

gatatgaagc gtgccgtaga ctgtccagaa aatattaaga aagagatctg tatcaataaa      180

atgctaaatc atgaaaatgt agtaaaattc tatggtcaca ggagagaagg caatatccaa      240

tatttatttc tggagtactg tagtggagga gagctttttg acagaataga gccagacata      300

ggcatgcctg aaccagatgc tcagagattc ttccatcaac tcatggcagg ggtggtttat      360

ctgcatggta ttggaataac tcacagggat attaaaccag aaaatcttct gttggatgaa      420

agggataacc tcaaaatctc agactttggc ttggcaacag tatttcggta taataatcgt      480

gagcgtttgt tgaacaagat gtgtggtact ttaccatatg ttgctccaga acttctgaag      540

agaagagaat ttcatgcaga accagttgat gtttggtcct gtggaatagt acttactgca      600

atgctcgctg gagaattgcc atgggaccaa cccagtgaca gctgtcagga gtattctgac      660

tggaaagaaa aaaaaacata cctcaaccct tggaaaaaaa tcgattctgc tcctctagct      720

ctgctgcata aaatcttagt tgagaatcca tcagcaagaa ttaccattcc agacatcaaa      780

aaagatagat ggtacaacaa acccctcaag aaaggggcaa aaaggccccg agtcacttca      840

ggtggtgtgt cagagtctcc cagtggattt tctaagcaca ttcaatccaa tttggacttc      900

tctccagtaa acagtgcttc tagtgaagaa aatgtgaagt actccagttc tcagccagaa      960

ccccgcacag gtctttcctt atgggatacc agcccctcat acattgataa attggtacaa     1020

gggatcagct tttcccagcc cacatgtcct gatcatatgc ttttgaatag tcagttactt     1080

ggcaccccag gatcctcaca gaacccctgg cagcggttgg tcaaaagaat gacacgattc     1140

tttaccaaat tggatgcaga caaatcttat caatgcctga aagagacttg tgagaagttg     1200

ggctatcaat ggaagaaaag ttgtatgaat caggttacta tatcaacaac tgataggaga     1260

aacaataaac tcattttcaa agtgaatttg ttagaaatgg atgataaaat attggttgac     1320

ttccggcttt ctaagggtga tggattggag ttcaagagac acttcctgaa gattaaaggg     1380

aagctgattg atattgtgag cagccagaag atttggcttc ctgccacatg a              1431


<210>  9
<211>  4174
<212>  DNA
<213>  Homo sapiens

<400>  9
cttttaaatt tgcgttgtaa gatttatttt ggctctcccc gcctgttctt tgcacattaa       60

aaatgaaaaa gtttgtagaa ctaagctaag cagatggtct tcctgcaaaa agaccgggct      120

gaagtaaagc attgttttgg agctggttca cagaaaaaag gcaaaactgg ttatcctgac      180

ttcaagctcc aacataaact gctcgctttc tccgggaaac ttgccccgcc acacacactt      240

gactgcgtgg ccagttcttt cgaagcctct cgctcccaac acggagttcc tcccatttct      300

tcacagtcgg ctctcagcag ctgctgctgg tttctcggct ccagcaccac gagtaccgca      360

ctctgaggtt tacaaagcac tctgcttcac cgactgtgat cctcacagtc ctgtccggtg      420

gcctcacgca ggtggcggtg cagcctttca ggcccagagc ggccaggagc gaagcccgca      480

gccccgcctg gaagcgcagc gcggtcggtc gcgcgcccct gaggcttgga ggcctgggct      540

tcccccagca gcgctcgagc accgcccagt cgagcctcac accggatgcc acttcatatt      600

tgggcccaga gctcaattcg cgccgatgcg gtccgccgtc cttaaatctc ttcagccagg      660

atctctcccc gactgcaaag cagccctggg cgggagcggc aacatctcca cgtcaccctt      720

ttggagccgc cgacattcag aggggcagga cacgggaacg cgcgctgtct tgctttacgg      780

cgcgggtgcg cgagtttgcg gcagcgtgac gccctcaagt tttggcggga aaagcgctgc      840

atttggattc ctgcagtggt gggcaaagga cagtccgccg aggtgctcgg tggagtcatg      900

gcagtgccct ttgtggaaga ctgggacttg gtgcaaaccc tgggagaagg tgcctatgga      960

gaagttcaac ttgctgtgaa tagagtaact gaagaagcag tcgcagtgaa gattgtagat     1020

atgaagcgtg ccgtagactg tccagaaaat attaagaaag agatctgtat caataaaatg     1080

ctaaatcatg aaaatgtagt aaaattctat ggtcacagga gagaaggcaa tatccaatat     1140

ttatttctgg agtactgtag tggaggagag ctttttgaca gaatagagcc agacataggc     1200

atgcctgaac cagatgctca gagattcttc catcaactca tggcaggggt ggtttatctg     1260

catggtattg gaataactca cagggatatt aaaccagaaa atcttctgtt ggatgaaagg     1320

gataacctca aaatctcaga ctttggcttg gcaacagtat ttcggtataa taatcgtgag     1380

cgtttgttga acaagatgtg tggtacttta ccatatgttg ctccagaact tctgaagaga     1440

agagaatttc atgcagaacc agttgatgtt tggtcctgtg gaatagtact tactgcaatg     1500

ctcgctggag aattgccatg ggaccaaccc agtgacagct gtcaggagta ttctgactgg     1560

aaagaaaaaa aaacatacct caacccttgg aaaaaaatcg attctgctcc tctagctctg     1620

ctgcataaaa tcttagttga gaatccatca gcaagaatta ccattccaga catcaaaaaa     1680

gatagatggt acaacaaacc cctcaagaaa ggggcaaaaa ggccccgagt cacttcaggt     1740

ggtgtgtcag agtctcccag tggattttct aagcacattc aatccaattt ggacttctct     1800

ccagtaaaca gtgcttctag tgaagaaaat gtgaagtact ccagttctca gccagaaccc     1860

cgcacaggtc tttccttatg ggataccagc ccctcataca ttgataaatt ggtacaaggg     1920

atcagctttt cccagcccac atgtcctgat catatgcttt tgaatagtca gttacttggc     1980

accccaggat cctcacagaa cccctggcag cggttggtca aaagaatgac acgattcttt     2040

accaaattgg atgcagacaa atcttatcaa tgcctgaaag agacttgtga gaagttgggc     2100

tatcaatgga agaaaagttg tatgaatcag gttactatat caacaactga taggagaaac     2160

aataaactca ttttcaaagt gaatttgtta gaaatggatg ataaaatatt ggttgacttc     2220

cggctttcta agggtgatgg attggagttc aagagacact tcctgaagat taaagggaag     2280

ctgattgata ttgtgagcag ccagaagatt tggcttcctg ccacatgatc ggaccatcgg     2340

ctctggggaa tcctggtgaa tatagtgctg ctatgttgac attattcttc ctagagaaga     2400

ttatcctgtc ctgcaaactg caaatagtag ttcctgaagt gttcacttcc ctgtttatcc     2460

aaacatcttc caatttattt tgtttgttcg gcatacaaat aatacctata tcttaattgt     2520

aagcaaaact ttggggaaag gatgaataga attcatttga ttatttcttc atgtgtgttt     2580

agtatctgaa tttgaaactc atctggtgga aaccaagttt caggggacat gagttttcca     2640

gcttttatac acacgtatct catttttatc aaaacatttt gtttaattca aaaagtacat     2700

attccatgtt gatttaattc taagatgaac caataaagac ataattcttg tgacttttgg     2760

acagtagatt tatcagtctg tgaagcgaag ccagcttcaa aacatatccc caagatttgt     2820

acttatattt tcaaaagggc ctggccagtt atataaacct gtttttgaat tataatgatt     2880

aattaaaatt gcaagtaggt gttttttcca gtgtagttag taaaatactt gtattttaca     2940

gtgttgcata aactctagtg cttaactaac tttactctaa aaattactgt tgaacatctt     3000

aaatattttt ctatattttc tactttcata gccatatttt aaccttttca acttactggt     3060

gaccaagctt ttaggtgata aagaataaaa gagggaaggg aagagtaagg aagctataag     3120

aaaaatagat ctgattcttt gttcctttac ctgttagact tacaaaaagt ttgtttttct     3180

aataaaattt gtatcaactt tggggcatat taggttgagg ccttggctcc tgcctgtagt     3240

cccagctact taggaggctg agagaggagg atcgcgtgaa cctggaagtt tgaggctgta     3300

gtgagctatg attgcaccag tgcactccag cttggatgac agagtaagac cctacctcta     3360

ataaaaattt ttaaaattgt aaaacattat aaaattaatc agttatttta atctgaagcc     3420

aagaacatgt agaatgttat gattagagtt tatcacatat taatgtatac tggcaaattg     3480

tgttactgga gtatacccat aggaggaata aattcaaacc tgttttattt atttgaacct     3540

atttacggta tgcttaagaa ttgaatcagt ataaattctc aaatatggga gaaattttgt     3600

tcttgagaat tatctgagtc attaatattt ttcaaaaaca gctctcactg acttgaacct     3660

cttctgtaag ctctaacctt ttacctgctt tacatttcca cttgaatgtc tagtaggcat     3720

ctcttgacca aaaacagctt ttgattcctg ttctccaacc tgttcctctc ctagttttct     3780

ccatctcaga aatgttactt cctctgcaaa gtctttccct gacttatcta aaataataac     3840

ctcctctgtt tgctgtggga atttgtatag aatggtggga aaatttcaag tttcatattt     3900

ggattagctc tgacatttat ttatctgaac actggtaatt gcctcagtaa agacactgat     3960

aataagtacc ttttagagtt attttaatct ttaatgcttt aatgtgtagg aagagtatag     4020

tgtcctgttt tgcacagaaa ggcattctgt aaataataag ttgccttaat tttcctgtaa     4080

tgttcattat attgttgtgg gaaggtattt actcctatta ttaaaaataa aaatgtgtaa     4140

aatttactac ctgaaaaaaa aaaaaaaaaa aaaa                                 4174


<210>  10
<211>  476
<212>  PRT
<213>  Homo sapiens

<400>  10

Met Ala Val Pro Phe Val Glu Asp Trp Asp Leu Val Gln Thr Leu Gly 
1               5                   10                  15      


Glu Gly Ala Tyr Gly Glu Val Gln Leu Ala Val Asn Arg Val Thr Glu 
            20                  25                  30          


Glu Ala Val Ala Val Lys Ile Val Asp Met Lys Arg Ala Val Asp Cys 
        35                  40                  45              


Pro Glu Asn Ile Lys Lys Glu Ile Cys Ile Asn Lys Met Leu Asn His 
    50                  55                  60                  


Glu Asn Val Val Lys Phe Tyr Gly His Arg Arg Glu Gly Asn Ile Gln 
65                  70                  75                  80  


Tyr Leu Phe Leu Glu Tyr Cys Ser Gly Gly Glu Leu Phe Asp Arg Ile 
                85                  90                  95      


Glu Pro Asp Ile Gly Met Pro Glu Pro Asp Ala Gln Arg Phe Phe His 
            100                 105                 110         


Gln Leu Met Ala Gly Val Val Tyr Leu His Gly Ile Gly Ile Thr His 
        115                 120                 125             


Arg Asp Ile Lys Pro Glu Asn Leu Leu Leu Asp Glu Arg Asp Asn Leu 
    130                 135                 140                 


Lys Ile Ser Asp Phe Gly Leu Ala Thr Val Phe Arg Tyr Asn Asn Arg 
145                 150                 155                 160 


Glu Arg Leu Leu Asn Lys Met Cys Gly Thr Leu Pro Tyr Val Ala Pro 
                165                 170                 175     


Glu Leu Leu Lys Arg Arg Glu Phe His Ala Glu Pro Val Asp Val Trp 
            180                 185                 190         


Ser Cys Gly Ile Val Leu Thr Ala Met Leu Ala Gly Glu Leu Pro Trp 
        195                 200                 205             


Asp Gln Pro Ser Asp Ser Cys Gln Glu Tyr Ser Asp Trp Lys Glu Lys 
    210                 215                 220                 


Lys Thr Tyr Leu Asn Pro Trp Lys Lys Ile Asp Ser Ala Pro Leu Ala 
225                 230                 235                 240 


Leu Leu His Lys Ile Leu Val Glu Asn Pro Ser Ala Arg Ile Thr Ile 
                245                 250                 255     


Pro Asp Ile Lys Lys Asp Arg Trp Tyr Asn Lys Pro Leu Lys Lys Gly 
            260                 265                 270         


Ala Lys Arg Pro Arg Val Thr Ser Gly Gly Val Ser Glu Ser Pro Ser 
        275                 280                 285             


Gly Phe Ser Lys His Ile Gln Ser Asn Leu Asp Phe Ser Pro Val Asn 
    290                 295                 300                 


Ser Ala Ser Ser Glu Glu Asn Val Lys Tyr Ser Ser Ser Gln Pro Glu 
305                 310                 315                 320 


Pro Arg Thr Gly Leu Ser Leu Trp Asp Thr Ser Pro Ser Tyr Ile Asp 
                325                 330                 335     


Lys Leu Val Gln Gly Ile Ser Phe Ser Gln Pro Thr Cys Pro Asp His 
            340                 345                 350         


Met Leu Leu Asn Ser Gln Leu Leu Gly Thr Pro Gly Ser Ser Gln Asn 
        355                 360                 365             


Pro Trp Gln Arg Leu Val Lys Arg Met Thr Arg Phe Phe Thr Lys Leu 
    370                 375                 380                 


Asp Ala Asp Lys Ser Tyr Gln Cys Leu Lys Glu Thr Cys Glu Lys Leu 
385                 390                 395                 400 


Gly Tyr Gln Trp Lys Lys Ser Cys Met Asn Gln Val Thr Ile Ser Thr 
                405                 410                 415     


Thr Asp Arg Arg Asn Asn Lys Leu Ile Phe Lys Val Asn Leu Leu Glu 
            420                 425                 430         


Met Asp Asp Lys Ile Leu Val Asp Phe Arg Leu Ser Lys Gly Asp Gly 
        435                 440                 445             


Leu Glu Phe Lys Arg His Phe Leu Lys Ile Lys Gly Lys Leu Ile Asp 
    450                 455                 460                 


Ile Val Ser Ser Gln Lys Ile Trp Leu Pro Ala Thr 
465                 470                 475     


<210>  11
<211>  1329
<212>  DNA
<213>  Homo sapiens

<400>  11
atggcagtgc cctttgtgga agactgggac ttggtgcaaa ccctgggaga aggtgcctat       60

ggagaagttc aacttgctgt gaatagagta actgaagaag cagtcgcagt gaagattgta      120

gatatgaagc gtgccgtaga ctgtccagaa aatattaaga aagagatctg tatcaataaa      180

atgctaaatc atgaaaatgt agtaaaattc tatggtcaca ggagagaagg caatatccaa      240

tatttatttc tggagtactg tagtggagga gagctttttg acagaataga gccagacata      300

ggcatgcctg aaccagatgc tcagagattc ttccatcaac tcatggcagg ggtggtttat      360

ctgcatggta ttggaataac tcacagggat attaaaccag aaaatcttct gttggatgaa      420

agggataacc tcaaaatctc agactttggc ttggcaacag tatttcggta taataatcgt      480

gagcgtttgt tgaacaagat gtgtggtact ttaccatatg ttgctccaga acttctgaag      540

agaagagaat ttcatgcaga accagttgat gtttggtcct gtggaatagt acttactgca      600

atgctcgctg gagaattgcc atgggaccaa cccagtgaca gctgtcagga gtattctgac      660

tggaaagaaa aaaaaacata cctcaaccct tggaaaaaaa tcgattctgc tcctctagct      720

ctgctgcata aaatcttagt tgagaatcca tcagcaagaa ttaccattcc agacatcaaa      780

aaagatagat ggtacaacaa acccctcaag aaaggggcaa aaaggccccg agtcacttca      840

ggtggtgtgt cagagtctcc cagtggattt tctaagcaca ttcaatccaa tttggacttc      900

tctccagtaa acagtgcttc tagtgaagaa aatgtgaagt actccagttc tcagccagaa      960

ccccgcacag gtctttcctt atgggatacc agcccctcat acattgataa attggtacaa     1020

gggatcagct tttcccagcc cacatgtcct gatcatatgc ttttgaatag tcagttactt     1080

ggcaccccag gatcctcaca gaacccctgg cagcggttgg tcaaaagaat gacacgattc     1140

tttaccaaat tggatgcaga caaatcttat caatgcctga aagagacttg tgagaagttg     1200

ggctatcaat ggaagaaaag ttgtatgaat cagggtgatg gattggagtt caagagacac     1260

ttcctgaaga ttaaagggaa gctgattgat attgtgagca gccagaagat ttggcttcct     1320

gccacatga                                                             1329


<210>  12
<211>  4072
<212>  DNA
<213>  Homo sapiens

<400>  12
cttttaaatt tgcgttgtaa gatttatttt ggctctcccc gcctgttctt tgcacattaa       60

aaatgaaaaa gtttgtagaa ctaagctaag cagatggtct tcctgcaaaa agaccgggct      120

gaagtaaagc attgttttgg agctggttca cagaaaaaag gcaaaactgg ttatcctgac      180

ttcaagctcc aacataaact gctcgctttc tccgggaaac ttgccccgcc acacacactt      240

gactgcgtgg ccagttcttt cgaagcctct cgctcccaac acggagttcc tcccatttct      300

tcacagtcgg ctctcagcag ctgctgctgg tttctcggct ccagcaccac gagtaccgca      360

ctctgaggtt tacaaagcac tctgcttcac cgactgtgat cctcacagtc ctgtccggtg      420

gcctcacgca ggtggcggtg cagcctttca ggcccagagc ggccaggagc gaagcccgca      480

gccccgcctg gaagcgcagc gcggtcggtc gcgcgcccct gaggcttgga ggcctgggct      540

tcccccagca gcgctcgagc accgcccagt cgagcctcac accggatgcc acttcatatt      600

tgggcccaga gctcaattcg cgccgatgcg gtccgccgtc cttaaatctc ttcagccagg      660

atctctcccc gactgcaaag cagccctggg cgggagcggc aacatctcca cgtcaccctt      720

ttggagccgc cgacattcag aggggcagga cacgggaacg cgcgctgtct tgctttacgg      780

cgcgggtgcg cgagtttgcg gcagcgtgac gccctcaagt tttggcggga aaagcgctgc      840

atttggattc ctgcagtggt gggcaaagga cagtccgccg aggtgctcgg tggagtcatg      900

gcagtgccct ttgtggaaga ctgggacttg gtgcaaaccc tgggagaagg tgcctatgga      960

gaagttcaac ttgctgtgaa tagagtaact gaagaagcag tcgcagtgaa gattgtagat     1020

atgaagcgtg ccgtagactg tccagaaaat attaagaaag agatctgtat caataaaatg     1080

ctaaatcatg aaaatgtagt aaaattctat ggtcacagga gagaaggcaa tatccaatat     1140

ttatttctgg agtactgtag tggaggagag ctttttgaca gaatagagcc agacataggc     1200

atgcctgaac cagatgctca gagattcttc catcaactca tggcaggggt ggtttatctg     1260

catggtattg gaataactca cagggatatt aaaccagaaa atcttctgtt ggatgaaagg     1320

gataacctca aaatctcaga ctttggcttg gcaacagtat ttcggtataa taatcgtgag     1380

cgtttgttga acaagatgtg tggtacttta ccatatgttg ctccagaact tctgaagaga     1440

agagaatttc atgcagaacc agttgatgtt tggtcctgtg gaatagtact tactgcaatg     1500

ctcgctggag aattgccatg ggaccaaccc agtgacagct gtcaggagta ttctgactgg     1560

aaagaaaaaa aaacatacct caacccttgg aaaaaaatcg attctgctcc tctagctctg     1620

ctgcataaaa tcttagttga gaatccatca gcaagaatta ccattccaga catcaaaaaa     1680

gatagatggt acaacaaacc cctcaagaaa ggggcaaaaa ggccccgagt cacttcaggt     1740

ggtgtgtcag agtctcccag tggattttct aagcacattc aatccaattt ggacttctct     1800

ccagtaaaca gtgcttctag tgaagaaaat gtgaagtact ccagttctca gccagaaccc     1860

cgcacaggtc tttccttatg ggataccagc ccctcataca ttgataaatt ggtacaaggg     1920

atcagctttt cccagcccac atgtcctgat catatgcttt tgaatagtca gttacttggc     1980

accccaggat cctcacagaa cccctggcag cggttggtca aaagaatgac acgattcttt     2040

accaaattgg atgcagacaa atcttatcaa tgcctgaaag agacttgtga gaagttgggc     2100

tatcaatgga agaaaagttg tatgaatcag ggtgatggat tggagttcaa gagacacttc     2160

ctgaagatta aagggaagct gattgatatt gtgagcagcc agaagatttg gcttcctgcc     2220

acatgatcgg accatcggct ctggggaatc ctggtgaata tagtgctgct atgttgacat     2280

tattcttcct agagaagatt atcctgtcct gcaaactgca aatagtagtt cctgaagtgt     2340

tcacttccct gtttatccaa acatcttcca atttattttg tttgttcggc atacaaataa     2400

tacctatatc ttaattgtaa gcaaaacttt ggggaaagga tgaatagaat tcatttgatt     2460

atttcttcat gtgtgtttag tatctgaatt tgaaactcat ctggtggaaa ccaagtttca     2520

ggggacatga gttttccagc ttttatacac acgtatctca tttttatcaa aacattttgt     2580

ttaattcaaa aagtacatat tccatgttga tttaattcta agatgaacca ataaagacat     2640

aattcttgtg acttttggac agtagattta tcagtctgtg aagcgaagcc agcttcaaaa     2700

catatcccca agatttgtac ttatattttc aaaagggcct ggccagttat ataaacctgt     2760

ttttgaatta taatgattaa ttaaaattgc aagtaggtgt tttttccagt gtagttagta     2820

aaatacttgt attttacagt gttgcataaa ctctagtgct taactaactt tactctaaaa     2880

attactgttg aacatcttaa atatttttct atattttcta ctttcatagc catattttaa     2940

ccttttcaac ttactggtga ccaagctttt aggtgataaa gaataaaaga gggaagggaa     3000

gagtaaggaa gctataagaa aaatagatct gattctttgt tcctttacct gttagactta     3060

caaaaagttt gtttttctaa taaaatttgt atcaactttg gggcatatta ggttgaggcc     3120

ttggctcctg cctgtagtcc cagctactta ggaggctgag agaggaggat cgcgtgaacc     3180

tggaagtttg aggctgtagt gagctatgat tgcaccagtg cactccagct tggatgacag     3240

agtaagaccc tacctctaat aaaaattttt aaaattgtaa aacattataa aattaatcag     3300

ttattttaat ctgaagccaa gaacatgtag aatgttatga ttagagttta tcacatatta     3360

atgtatactg gcaaattgtg ttactggagt atacccatag gaggaataaa ttcaaacctg     3420

ttttatttat ttgaacctat ttacggtatg cttaagaatt gaatcagtat aaattctcaa     3480

atatgggaga aattttgttc ttgagaatta tctgagtcat taatattttt caaaaacagc     3540

tctcactgac ttgaacctct tctgtaagct ctaacctttt acctgcttta catttccact     3600

tgaatgtcta gtaggcatct cttgaccaaa aacagctttt gattcctgtt ctccaacctg     3660

ttcctctcct agttttctcc atctcagaaa tgttacttcc tctgcaaagt ctttccctga     3720

cttatctaaa ataataacct cctctgtttg ctgtgggaat ttgtatagaa tggtgggaaa     3780

atttcaagtt tcatatttgg attagctctg acatttattt atctgaacac tggtaattgc     3840

ctcagtaaag acactgataa taagtacctt ttagagttat tttaatcttt aatgctttaa     3900

tgtgtaggaa gagtatagtg tcctgttttg cacagaaagg cattctgtaa ataataagtt     3960

gccttaattt tcctgtaatg ttcattatat tgttgtggga aggtatttac tcctattatt     4020

aaaaataaaa atgtgtaaaa tttactacct gaaaaaaaaa aaaaaaaaaa aa             4072


<210>  13
<211>  442
<212>  PRT
<213>  Homo sapiens

<400>  13

Met Ala Val Pro Phe Val Glu Asp Trp Asp Leu Val Gln Thr Leu Gly 
1               5                   10                  15      


Glu Gly Ala Tyr Gly Glu Val Gln Leu Ala Val Asn Arg Val Thr Glu 
            20                  25                  30          


Glu Ala Val Ala Val Lys Ile Val Asp Met Lys Arg Ala Val Asp Cys 
        35                  40                  45              


Pro Glu Asn Ile Lys Lys Glu Ile Cys Ile Asn Lys Met Leu Asn His 
    50                  55                  60                  


Glu Asn Val Val Lys Phe Tyr Gly His Arg Arg Glu Gly Asn Ile Gln 
65                  70                  75                  80  


Tyr Leu Phe Leu Glu Tyr Cys Ser Gly Gly Glu Leu Phe Asp Arg Ile 
                85                  90                  95      


Glu Pro Asp Ile Gly Met Pro Glu Pro Asp Ala Gln Arg Phe Phe His 
            100                 105                 110         


Gln Leu Met Ala Gly Val Val Tyr Leu His Gly Ile Gly Ile Thr His 
        115                 120                 125             


Arg Asp Ile Lys Pro Glu Asn Leu Leu Leu Asp Glu Arg Asp Asn Leu 
    130                 135                 140                 


Lys Ile Ser Asp Phe Gly Leu Ala Thr Val Phe Arg Tyr Asn Asn Arg 
145                 150                 155                 160 


Glu Arg Leu Leu Asn Lys Met Cys Gly Thr Leu Pro Tyr Val Ala Pro 
                165                 170                 175     


Glu Leu Leu Lys Arg Arg Glu Phe His Ala Glu Pro Val Asp Val Trp 
            180                 185                 190         


Ser Cys Gly Ile Val Leu Thr Ala Met Leu Ala Gly Glu Leu Pro Trp 
        195                 200                 205             


Asp Gln Pro Ser Asp Ser Cys Gln Glu Tyr Ser Asp Trp Lys Glu Lys 
    210                 215                 220                 


Lys Thr Tyr Leu Asn Pro Trp Lys Lys Ile Asp Ser Ala Pro Leu Ala 
225                 230                 235                 240 


Leu Leu His Lys Ile Leu Val Glu Asn Pro Ser Ala Arg Ile Thr Ile 
                245                 250                 255     


Pro Asp Ile Lys Lys Asp Arg Trp Tyr Asn Lys Pro Leu Lys Lys Gly 
            260                 265                 270         


Ala Lys Arg Pro Arg Val Thr Ser Gly Gly Val Ser Glu Ser Pro Ser 
        275                 280                 285             


Gly Phe Ser Lys His Ile Gln Ser Asn Leu Asp Phe Ser Pro Val Asn 
    290                 295                 300                 


Ser Ala Ser Ser Glu Glu Asn Val Lys Tyr Ser Ser Ser Gln Pro Glu 
305                 310                 315                 320 


Pro Arg Thr Gly Leu Ser Leu Trp Asp Thr Ser Pro Ser Tyr Ile Asp 
                325                 330                 335     


Lys Leu Val Gln Gly Ile Ser Phe Ser Gln Pro Thr Cys Pro Asp His 
            340                 345                 350         


Met Leu Leu Asn Ser Gln Leu Leu Gly Thr Pro Gly Ser Ser Gln Asn 
        355                 360                 365             


Pro Trp Gln Arg Leu Val Lys Arg Met Thr Arg Phe Phe Thr Lys Leu 
    370                 375                 380                 


Asp Ala Asp Lys Ser Tyr Gln Cys Leu Lys Glu Thr Cys Glu Lys Leu 
385                 390                 395                 400 


Gly Tyr Gln Trp Lys Lys Ser Cys Met Asn Gln Gly Asp Gly Leu Glu 
                405                 410                 415     


Phe Lys Arg His Phe Leu Lys Ile Lys Gly Lys Leu Ile Asp Ile Val 
            420                 425                 430         


Ser Ser Gln Lys Ile Trp Leu Pro Ala Thr 
        435                 440         


<210>  14
<211>  7935
<212>  DNA
<213>  Homo sapiens

<400>  14
atgggggaac atggcctgga gctggcttcc atgatccccg ccctgcggga gctgggcagt       60

gccacaccag aggaatataa tacagttgta cagaagccaa gacaaattct gtgtcaattc      120

attgaccgga tacttacaga tgtaaatgtt gttgctgtag aacttgtaaa gaaaactgac      180

tctcagccaa cctccgtgat gttgcttgat ttcatccagc atatcatgaa atcctcccca      240

cttatgtttg taaatgtgag tggaagccat gaggccaaag gcagttgtat tgaattcagt      300

aattggatca taacgagact tctgcggatt gcagcaactc cctcctgtca tttgttacac      360

aagaaaatct gtgaagtcat ctgttcatta ttatttcttt ttaaaagcaa gagtcctgct      420

atttttgggg tactcacaaa agaattatta caactttttg aagacttggt ttacctccat      480

agaagaaatg tgatgggtca tgctgtggaa tggccagtgg tcatgagccg atttttaagt      540

caattagatg aacacatggg atatttacaa tcagctcctt tgcagttgat gagtatgcaa      600

aatttagaat ttattgaagt cactttatta atggttctta ctcgtattat tgcaattgtg      660

ttttttagaa ggcaagaact cttactttgg cagataggtt gtgttctgct agagtatggt      720

agtccaaaaa ttaaatccct agcaattagc tttttaacag aactttttca gcttggagga      780

ctaccagcac aaccagctag cacttttttc agctcatttt tggaattatt aaaacacctt      840

gtagaaatgg atactgacca attgaaactc tatgaagagc cattatcaaa gctgataaag      900

acactatttc cctttgaagc agaagcttat agaaatattg aacctgtcta tttaaatatg      960

ctgctggaaa aactctgtgt catgtttgaa gacggtgtgc tcatgcggct taagtctgat     1020

ttgctaaaag cagctttgtg ccatttactg cagtatttcc ttaaatttgt gccagctggg     1080

tatgaatctg ctttacaagt caggaaggtc tatgtgagaa atatttgtaa agctcttttg     1140

gatgtgcttg gaattgaggt agatgcagag tacttgttgg gcccacttta tgcagctttg     1200

aaaatggaaa gtatggaaat cattgaggag attcaatgcc aaactcaaca ggaaaacctc     1260

agcagtaata gtgatggaat atcacccaaa aggcgtcgtc tcagctcgtc tctaaaccct     1320

tctaaaagag caccaaaaca gactgaggaa attaaacatg tggacatgaa ccaaaagagc     1380

atattatgga gtgcactgaa acagaaagct gaatcccttc agatttccct tgaatacagt     1440

ggcctaaaga atcctgttat tgagatgtta gaaggaattg ctgttgtctt acaactgact     1500

gctctgtgta ctgttcattg ttctcatcaa aacatgaact gccgtacttt caaggactgt     1560

caacataaat ccaagaagaa accttctgta gtgataactt ggatgtcatt ggatttttac     1620

acaaaagtgc ttaagagctg tagaagtttg ttagaatctg ttcagaaact ggacctggag     1680

gcaaccattg ataaggtggt gaaaatttat gatgctttga tttatatgca agtaaacagt     1740

tcatttgaag atcatatcct ggaagattta tgtggtatgc tctcacttcc atggatttat     1800

tcccattctg atgatggctg tttaaagttg accacatttg ccgctaatct tctaacatta     1860

agctgtagga tttcagatag ctattcacca caggcacaat cacgatgtgt gtttcttctg     1920

actctgtttc caagaagaat attccttgag tggagaacag cagtttacaa ctgggccctg     1980

cagagctccc atgaagtaat ccgggctagt tgtgttagtg gattttttat cttattgcag     2040

cagcagaatt cttgtaacag agttcccaag attcttatag ataaagtcaa agatgattct     2100

gacattgtca agaaagaatt tgcttctata cttggtcaac ttgtctgtac tcttcacggc     2160

atgttttatc tgacaagttc tttaacagaa cctttctctg aacacggaca tgtggacctc     2220

ttctgtagga acttgaaagc cacttctcaa catgaatgtt catcttctca actaaaagct     2280

tctgtctgca agccattcct tttcctactg aaaaaaaaaa tacctagtcc agtaaaactt     2340

gctttcatag ataatctaca tcatctttgt aagcatcttg attttagaga agatgaaaca     2400

gatgtaaaag cagttcttgg aactttatta aatttaatgg aagatccaga caaagatgtt     2460

agagtggctt ttagtggaaa tatcaagcac atattggaat ccttggactc tgaagatgga     2520

tttataaagg agctttttgt cttaagaatg aaggaagcat atacacatgc ccaaatatca     2580

agaaataatg agctgaagga taccttgatt cttacaacag gggatattgg aagggccgca     2640

aaaggagatt tggtaccatt tgcactctta cacttattgc attgtttgtt atccaagtca     2700

gcatctgtct ctggagcagc atacacagaa attagagctc tggttgcagc taaaagtgtt     2760

aaactgcaaa gttttttcag ccagtataag aaacccatct gtcagttttt ggtagaatcc     2820

cttcactcta gtcagatgac agcacttccg aatactccat gccagaatgc tgacgtgcga     2880

aaacaagatg tggctcacca gagagaaatg gctttaaata cgttgtctga aattgccaac     2940

gttttcgact ttcctgatct taatcgtttt cttactagga cattacaagt tctactacct     3000

gatcttgctg ccaaagcaag ccctgcagct tctgctctca ttcgaacttt aggaaaacaa     3060

ttaaatgtca atcgtagaga gattttaata aacaacttca aatatatttt ttctcatttg     3120

gtctgttctt gttccaaaga tgaattagaa cgtgcccttc attatctgaa gaatgaaaca     3180

gaaattgaac tggggagcct gttgagacaa gatttccaag gattgcataa tgaattattg     3240

ctgcgtattg gagaacacta tcaacaggtt tttaatggtt tgtcaatact tgcctcattt     3300

gcatccagtg atgatccata tcagggcccg agagatatca tatcacctga actgatggct     3360

gattatttac aacccaaatt gttgggcatt ttggcttttt ttaacatgca gttactgagc     3420

tctagtgttg gcattgaaga taagaaaatg gccttgaaca gtttgatgtc tttgatgaag     3480

ttaatgggac ccaaacatgt cagttctgtg agggtgaaga tgatgaccac actgagaact     3540

ggccttcgat tcaaggatga ttttcctgaa ttgtgttgca gagcttggga ctgctttgtt     3600

cgctgcctgg atcatgcttg tctgggctcc cttctcagtc atgtaatagt agctttgtta     3660

cctcttatac acatccagcc taaagaaact gcagctatct tccactacct cataattgaa     3720

aacagggatg ctgtgcaaga ttttcttcat gaaatatatt ttttacctga tcatccagaa     3780

ttaaaaaaga taaaagccgt tctccaggaa tacagaaagg agacctctga gagcactgat     3840

cttcagacaa ctcttcagct ctctatgaag gccattcaac atgaaaatgt cgatgttcgt     3900

attcatgctc ttacaagctt gaaggaaacc ttgtataaaa atcaggaaaa actgataaag     3960

tatgcaacag acagtgaaac agtagaacct attatctcac agttggtgac agtgcttttg     4020

aaaggttgcc aagatgcaaa ctctcaagct cggttgctct gtggggaatg tttaggggaa     4080

ttgggggcga tagatccagg tcgattagat ttctcaacaa ctgaaactca aggaaaagat     4140

tttacatttg tgactggagt agaagattca agctttgcct atggattatt gatggagcta     4200

acaagagctt accttgcgta tgctgataat agccgagctc aagattcagc tgcctatgcc     4260

attcaggagt tgctttctat ttatgactgt agagagatgg agaccaacgg cccaggtcac     4320

caattgtgga ggagatttcc tgagcatgtt cgggaaatac tagaacctca tctaaatacc     4380

agatacaaga gttctcagaa gtcaaccgat tggtctggag taaagaagcc aatttactta     4440

agtaaattgg gtagtaactt tgcagaatgg tcagcatctt gggcaggtta tcttattaca     4500

aaggttcgac atgatcttgc cagtaaaatt ttcacctgct gtagcattat gatgaagcat     4560

gatttcaaag tgaccatcta tcttcttcca catattctgg tgtatgtctt actgggttgt     4620

aatcaagaag atcagcagga ggtttatgca gaaattatgg cagttctaaa gcatgacgat     4680

cagcatacca taaataccca agacattgca tctgatctgt gtcaactcag tacacagact     4740

gtgttctcca tgcttgacca tctcacacag tgggcaaggc acaaatttca ggcactgaaa     4800

gctgagaaat gtccacacag caaatcaaac agaaataagg tagactcaat ggtatctact     4860

gtggattatg aagactatca gagtgtaacc cgttttctag acctcatacc ccaggatact     4920

ctggcagtag cttcctttcg ctccaaagca tacacacgag ctgtaatgca ctttgaatca     4980

tttattacag aaaagaagca aaatattcag gaacatcttg gatttttaca gaaattgtat     5040

gctgctatgc atgaacctga tggagtggcc ggagtcagtg caattagaaa ggcagaacca     5100

tctctaaaag aacagatcct tgaacatgaa agccttggct tgctgaggga tgccactgct     5160

tgttatgaca gggctattca gctagaacca gaccagatca ttcattatca tggtgtagta     5220

aagtccatgt taggtcttgg tcagctgtct actgttatca ctcaggtgaa tggagtgcat     5280

gctaacaggt ccgagtggac agatgaatta aacacgtaca gagtggaagc agcttggaaa     5340

ttgtcacagt gggatttggt ggaaaactat ttggcagcag atggaaaatc tacaacatgg     5400

agtgtcagac tgggacagct attattatca gccaaaaaaa gagatatcac agctttttat     5460

gactcactga aactagtgag agcagaacaa attgtacctc tttcagctgc aagctttgaa     5520

agaggctcct accaacgagg atatgaatat attgtgagat tgcacatgtt atgtgagttg     5580

gagcatagca tcaaaccact tttccagcat tctccaggtg acagttctca agaagattct     5640

ctaaactggg tagctcgact agaaatgacc cagaattcct acagagccaa ggagcctatc     5700

ctggctctcc ggagggcttt actaagcctc aacaaaagac cagattacaa tgaaatggtt     5760

ggagaatgct ggctgcagag tgccagggta gctagaaagg ctggtcacca ccagacagcc     5820

tacaatgctc tccttaatgc aggggaatca cgactcgctg aactgtacgt ggaaagggca     5880

aagtggctct ggtccaaggg tgatgttcac caggcactaa ttgttcttca aaaaggtgtt     5940

gaattatgtt ttcctgaaaa tgaaacccca cctgagggta agaacatgtt aatccatggt     6000

cgagctatgc tactagtggg ccgatttatg gaagaaacag ctaactttga aagcaatgca     6060

attatgaaaa aatataagga tgtgaccgcg tgcctgccag aatgggagga tgggcatttt     6120

taccttgcca agtactatga caaattgatg cccatggtca cagacaacaa aatggaaaag     6180

caaggtgatc tcatccggta tatagttctt cattttggca gatctctaca atatggaaat     6240

cagttcatat atcagtcaat gccacgaatg ttaactctat ggcttgatta tggtacaaag     6300

gcatatgaat gggaaaaagc tggccgctcc gatcgtgtac aaatgaggaa tgatttgggt     6360

aaaataaaca aggttatcac agagcataca aactatttag ctccatatca atttttgact     6420

gctttttcac aattgatctc tcgaatttgt cattctcacg atgaagtttt tgttgtcttg     6480

atggaaataa tagccaaagt atttctagcc tatcctcaac aagcaatgtg gatgatgaca     6540

gctgtgtcaa agtcatctta tcccatgcgt gtgaacagat gcaaggaaat cctcaataaa     6600

gctattcata tgaaaaaatc cttagagaag tttgttggag atgcaactcg cctaacagat     6660

aagcttctag aattgtgcaa taaaccggtt gatggaagta gttccacatt aagcatgagc     6720

actcatttta aaatgcttaa aaagctggta gaagaagcaa catttagtga aatcctcatt     6780

cctctacaat cagtcatgat acctacactt ccatcaattc tgggtaccca tgctaaccat     6840

gctagccatg aaccatttcc tggacattgg gcctatattg cagggtttga tgatatggtg     6900

gaaattcttg cttctcttca gaaaccaaag aagatttctt taaaaggctc agatggaaag     6960

ttctacatca tgatgtgtaa gccaaaagat gacctgagaa aggattgtag actaatggaa     7020

ttcaattcct tgattaataa gtgcttaaga aaagatgcag agtctcgtag aagagaactt     7080

catattcgaa catatgcagt tattccacta aatgatgaat gtgggattat tgaatgggtg     7140

aacaacactg ctggtttgag acctattctg accaaactat ataaagaaaa gggagtgtat     7200

atgacaggaa aagaacttcg ccagtgtatg ctaccaaagt cagcagcttt atctgaaaaa     7260

ctcaaagtat tccgagaatt tctcctgccc aggcatcctc ctatttttca tgagtggttt     7320

ctgagaacat tccctgatcc tacatcatgg tacagtagta gatcagctta ctgccgttcc     7380

actgcagtaa tgtcaatggt tggttatatt ctggggcttg gagaccgtca tggtgaaaat     7440

attctctttg attctttgac tggtgaatgc gtacatgtag atttcaattg tcttttcaat     7500

aagggagaaa cctttgaagt tccagaaatt gtgccatttc gcctgactca taatatggtt     7560

aatggaatgg gtcctatggg aacagagggt ctttttcgaa gagcatgtga agttacaatg     7620

aggctgatgc gtgatcagcg agagccttta atgagtgtct taaagacttt tctacatgat     7680

cctcttgtgg aatggagtaa accagtgaaa gggcattcca aagcgccact gaatgaaact     7740

ggagaagttg tcaatgaaaa ggccaagacc catgttcttg acattgagca gcgactacaa     7800

ggtgtaatca agactcgaaa tagagtgaca ggactgccgt tatctattga aggacatgtg     7860

cattacctta tacaggaagc tactgatgaa aacttactat gccagatgta tcttggttgg     7920

actccatata tgtga                                                      7935


<210>  15
<211>  8258
<212>  DNA
<213>  Homo sapiens

<400>  15
ttccgggagg agttttggcc tccacacggc tccgtcgggc gccgcgctct tccggcagcg       60

gtagctttgg agacgccggg aacccgcgtt ggcgtggttg actagtgcct cgcagcctca      120

gcatggggga acatggcctg gagctggctt ccatgatccc cgccctgcgg gagctgggca      180

gtgccacacc agaggaatat aatacagttg tacagaagcc aagacaaatt ctgtgtcaat      240

tcattgaccg gatacttaca gatgtaaatg ttgttgctgt agaacttgta aagaaaactg      300

actctcagcc aacctccgtg atgttgcttg atttcatcca gcatatcatg aaatcctccc      360

cacttatgtt tgtaaatgtg agtggaagcc atgaggccaa aggcagttgt attgaattca      420

gtaattggat cataacgaga cttctgcgga ttgcagcaac tccctcctgt catttgttac      480

acaagaaaat ctgtgaagtc atctgttcat tattatttct ttttaaaagc aagagtcctg      540

ctatttttgg ggtactcaca aaagaattat tacaactttt tgaagacttg gtttacctcc      600

atagaagaaa tgtgatgggt catgctgtgg aatggccagt ggtcatgagc cgatttttaa      660

gtcaattaga tgaacacatg ggatatttac aatcagctcc tttgcagttg atgagtatgc      720

aaaatttaga atttattgaa gtcactttat taatggttct tactcgtatt attgcaattg      780

tgttttttag aaggcaagaa ctcttacttt ggcagatagg ttgtgttctg ctagagtatg      840

gtagtccaaa aattaaatcc ctagcaatta gctttttaac agaacttttt cagcttggag      900

gactaccagc acaaccagct agcacttttt tcagctcatt tttggaatta ttaaaacacc      960

ttgtagaaat ggatactgac caattgaaac tctatgaaga gccattatca aagctgataa     1020

agacactatt tccctttgaa gcagaagctt atagaaatat tgaacctgtc tatttaaata     1080

tgctgctgga aaaactctgt gtcatgtttg aagacggtgt gctcatgcgg cttaagtctg     1140

atttgctaaa agcagctttg tgccatttac tgcagtattt ccttaaattt gtgccagctg     1200

ggtatgaatc tgctttacaa gtcaggaagg tctatgtgag aaatatttgt aaagctcttt     1260

tggatgtgct tggaattgag gtagatgcag agtacttgtt gggcccactt tatgcagctt     1320

tgaaaatgga aagtatggaa atcattgagg agattcaatg ccaaactcaa caggaaaacc     1380

tcagcagtaa tagtgatgga atatcaccca aaaggcgtcg tctcagctcg tctctaaacc     1440

cttctaaaag agcaccaaaa cagactgagg aaattaaaca tgtggacatg aaccaaaaga     1500

gcatattatg gagtgcactg aaacagaaag ctgaatccct tcagatttcc cttgaataca     1560

gtggcctaaa gaatcctgtt attgagatgt tagaaggaat tgctgttgtc ttacaactga     1620

ctgctctgtg tactgttcat tgttctcatc aaaacatgaa ctgccgtact ttcaaggact     1680

gtcaacataa atccaagaag aaaccttctg tagtgataac ttggatgtca ttggattttt     1740

acacaaaagt gcttaagagc tgtagaagtt tgttagaatc tgttcagaaa ctggacctgg     1800

aggcaaccat tgataaggtg gtgaaaattt atgatgcttt gatttatatg caagtaaaca     1860

gttcatttga agatcatatc ctggaagatt tatgtggtat gctctcactt ccatggattt     1920

attcccattc tgatgatggc tgtttaaagt tgaccacatt tgccgctaat cttctaacat     1980

taagctgtag gatttcagat agctattcac cacaggcaca atcacgatgt gtgtttcttc     2040

tgactctgtt tccaagaaga atattccttg agtggagaac agcagtttac aactgggccc     2100

tgcagagctc ccatgaagta atccgggcta gttgtgttag tggatttttt atcttattgc     2160

agcagcagaa ttcttgtaac agagttccca agattcttat agataaagtc aaagatgatt     2220

ctgacattgt caagaaagaa tttgcttcta tacttggtca acttgtctgt actcttcacg     2280

gcatgtttta tctgacaagt tctttaacag aacctttctc tgaacacgga catgtggacc     2340

tcttctgtag gaacttgaaa gccacttctc aacatgaatg ttcatcttct caactaaaag     2400

cttctgtctg caagccattc cttttcctac tgaaaaaaaa aatacctagt ccagtaaaac     2460

ttgctttcat agataatcta catcatcttt gtaagcatct tgattttaga gaagatgaaa     2520

cagatgtaaa agcagttctt ggaactttat taaatttaat ggaagatcca gacaaagatg     2580

ttagagtggc ttttagtgga aatatcaagc acatattgga atccttggac tctgaagatg     2640

gatttataaa ggagcttttt gtcttaagaa tgaaggaagc atatacacat gcccaaatat     2700

caagaaataa tgagctgaag gataccttga ttcttacaac aggggatatt ggaagggccg     2760

caaaaggaga tttggtacca tttgcactct tacacttatt gcattgtttg ttatccaagt     2820

cagcatctgt ctctggagca gcatacacag aaattagagc tctggttgca gctaaaagtg     2880

ttaaactgca aagttttttc agccagtata agaaacccat ctgtcagttt ttggtagaat     2940

cccttcactc tagtcagatg acagcacttc cgaatactcc atgccagaat gctgacgtgc     3000

gaaaacaaga tgtggctcac cagagagaaa tggctttaaa tacgttgtct gaaattgcca     3060

acgttttcga ctttcctgat cttaatcgtt ttcttactag gacattacaa gttctactac     3120

ctgatcttgc tgccaaagca agccctgcag cttctgctct cattcgaact ttaggaaaac     3180

aattaaatgt caatcgtaga gagattttaa taaacaactt caaatatatt ttttctcatt     3240

tggtctgttc ttgttccaaa gatgaattag aacgtgccct tcattatctg aagaatgaaa     3300

cagaaattga actggggagc ctgttgagac aagatttcca aggattgcat aatgaattat     3360

tgctgcgtat tggagaacac tatcaacagg tttttaatgg tttgtcaata cttgcctcat     3420

ttgcatccag tgatgatcca tatcagggcc cgagagatat catatcacct gaactgatgg     3480

ctgattattt acaacccaaa ttgttgggca ttttggcttt ttttaacatg cagttactga     3540

gctctagtgt tggcattgaa gataagaaaa tggccttgaa cagtttgatg tctttgatga     3600

agttaatggg acccaaacat gtcagttctg tgagggtgaa gatgatgacc acactgagaa     3660

ctggccttcg attcaaggat gattttcctg aattgtgttg cagagcttgg gactgctttg     3720

ttcgctgcct ggatcatgct tgtctgggct cccttctcag tcatgtaata gtagctttgt     3780

tacctcttat acacatccag cctaaagaaa ctgcagctat cttccactac ctcataattg     3840

aaaacaggga tgctgtgcaa gattttcttc atgaaatata ttttttacct gatcatccag     3900

aattaaaaaa gataaaagcc gttctccagg aatacagaaa ggagacctct gagagcactg     3960

atcttcagac aactcttcag ctctctatga aggccattca acatgaaaat gtcgatgttc     4020

gtattcatgc tcttacaagc ttgaaggaaa ccttgtataa aaatcaggaa aaactgataa     4080

agtatgcaac agacagtgaa acagtagaac ctattatctc acagttggtg acagtgcttt     4140

tgaaaggttg ccaagatgca aactctcaag ctcggttgct ctgtggggaa tgtttagggg     4200

aattgggggc gatagatcca ggtcgattag atttctcaac aactgaaact caaggaaaag     4260

attttacatt tgtgactgga gtagaagatt caagctttgc ctatggatta ttgatggagc     4320

taacaagagc ttaccttgcg tatgctgata atagccgagc tcaagattca gctgcctatg     4380

ccattcagga gttgctttct atttatgact gtagagagat ggagaccaac ggcccaggtc     4440

accaattgtg gaggagattt cctgagcatg ttcgggaaat actagaacct catctaaata     4500

ccagatacaa gagttctcag aagtcaaccg attggtctgg agtaaagaag ccaatttact     4560

taagtaaatt gggtagtaac tttgcagaat ggtcagcatc ttgggcaggt tatcttatta     4620

caaaggttcg acatgatctt gccagtaaaa ttttcacctg ctgtagcatt atgatgaagc     4680

atgatttcaa agtgaccatc tatcttcttc cacatattct ggtgtatgtc ttactgggtt     4740

gtaatcaaga agatcagcag gaggtttatg cagaaattat ggcagttcta aagcatgacg     4800

atcagcatac cataaatacc caagacattg catctgatct gtgtcaactc agtacacaga     4860

ctgtgttctc catgcttgac catctcacac agtgggcaag gcacaaattt caggcactga     4920

aagctgagaa atgtccacac agcaaatcaa acagaaataa ggtagactca atggtatcta     4980

ctgtggatta tgaagactat cagagtgtaa cccgttttct agacctcata ccccaggata     5040

ctctggcagt agcttccttt cgctccaaag catacacacg agctgtaatg cactttgaat     5100

catttattac agaaaagaag caaaatattc aggaacatct tggattttta cagaaattgt     5160

atgctgctat gcatgaacct gatggagtgg ccggagtcag tgcaattaga aaggcagaac     5220

catctctaaa agaacagatc cttgaacatg aaagccttgg cttgctgagg gatgccactg     5280

cttgttatga cagggctatt cagctagaac cagaccagat cattcattat catggtgtag     5340

taaagtccat gttaggtctt ggtcagctgt ctactgttat cactcaggtg aatggagtgc     5400

atgctaacag gtccgagtgg acagatgaat taaacacgta cagagtggaa gcagcttgga     5460

aattgtcaca gtgggatttg gtggaaaact atttggcagc agatggaaaa tctacaacat     5520

ggagtgtcag actgggacag ctattattat cagccaaaaa aagagatatc acagcttttt     5580

atgactcact gaaactagtg agagcagaac aaattgtacc tctttcagct gcaagctttg     5640

aaagaggctc ctaccaacga ggatatgaat atattgtgag attgcacatg ttatgtgagt     5700

tggagcatag catcaaacca cttttccagc attctccagg tgacagttct caagaagatt     5760

ctctaaactg ggtagctcga ctagaaatga cccagaattc ctacagagcc aaggagccta     5820

tcctggctct ccggagggct ttactaagcc tcaacaaaag accagattac aatgaaatgg     5880

ttggagaatg ctggctgcag agtgccaggg tagctagaaa ggctggtcac caccagacag     5940

cctacaatgc tctccttaat gcaggggaat cacgactcgc tgaactgtac gtggaaaggg     6000

caaagtggct ctggtccaag ggtgatgttc accaggcact aattgttctt caaaaaggtg     6060

ttgaattatg ttttcctgaa aatgaaaccc cacctgaggg taagaacatg ttaatccatg     6120

gtcgagctat gctactagtg ggccgattta tggaagaaac agctaacttt gaaagcaatg     6180

caattatgaa aaaatataag gatgtgaccg cgtgcctgcc agaatgggag gatgggcatt     6240

tttaccttgc caagtactat gacaaattga tgcccatggt cacagacaac aaaatggaaa     6300

agcaaggtga tctcatccgg tatatagttc ttcattttgg cagatctcta caatatggaa     6360

atcagttcat atatcagtca atgccacgaa tgttaactct atggcttgat tatggtacaa     6420

aggcatatga atgggaaaaa gctggccgct ccgatcgtgt acaaatgagg aatgatttgg     6480

gtaaaataaa caaggttatc acagagcata caaactattt agctccatat caatttttga     6540

ctgctttttc acaattgatc tctcgaattt gtcattctca cgatgaagtt tttgttgtct     6600

tgatggaaat aatagccaaa gtatttctag cctatcctca acaagcaatg tggatgatga     6660

cagctgtgtc aaagtcatct tatcccatgc gtgtgaacag atgcaaggaa atcctcaata     6720

aagctattca tatgaaaaaa tccttagaga agtttgttgg agatgcaact cgcctaacag     6780

ataagcttct agaattgtgc aataaaccgg ttgatggaag tagttccaca ttaagcatga     6840

gcactcattt taaaatgctt aaaaagctgg tagaagaagc aacatttagt gaaatcctca     6900

ttcctctaca atcagtcatg atacctacac ttccatcaat tctgggtacc catgctaacc     6960

atgctagcca tgaaccattt cctggacatt gggcctatat tgcagggttt gatgatatgg     7020

tggaaattct tgcttctctt cagaaaccaa agaagatttc tttaaaaggc tcagatggaa     7080

agttctacat catgatgtgt aagccaaaag atgacctgag aaaggattgt agactaatgg     7140

aattcaattc cttgattaat aagtgcttaa gaaaagatgc agagtctcgt agaagagaac     7200

ttcatattcg aacatatgca gttattccac taaatgatga atgtgggatt attgaatggg     7260

tgaacaacac tgctggtttg agacctattc tgaccaaact atataaagaa aagggagtgt     7320

atatgacagg aaaagaactt cgccagtgta tgctaccaaa gtcagcagct ttatctgaaa     7380

aactcaaagt attccgagaa tttctcctgc ccaggcatcc tcctattttt catgagtggt     7440

ttctgagaac attccctgat cctacatcat ggtacagtag tagatcagct tactgccgtt     7500

ccactgcagt aatgtcaatg gttggttata ttctggggct tggagaccgt catggtgaaa     7560

atattctctt tgattctttg actggtgaat gcgtacatgt agatttcaat tgtcttttca     7620

ataagggaga aacctttgaa gttccagaaa ttgtgccatt tcgcctgact cataatatgg     7680

ttaatggaat gggtcctatg ggaacagagg gtctttttcg aagagcatgt gaagttacaa     7740

tgaggctgat gcgtgatcag cgagagcctt taatgagtgt cttaaagact tttctacatg     7800

atcctcttgt ggaatggagt aaaccagtga aagggcattc caaagcgcca ctgaatgaaa     7860

ctggagaagt tgtcaatgaa aaggccaaga cccatgttct tgacattgag cagcgactac     7920

aaggtgtaat caagactcga aatagagtga caggactgcc gttatctatt gaaggacatg     7980

tgcattacct tatacaggaa gctactgatg aaaacttact atgccagatg tatcttggtt     8040

ggactccata tatgtgaaat gaaattatgt aaaagaatat gttaataatc taaaagtaat     8100

gcatttggta tgaatctgtg gttgtatctg ttcaattcta aagtacaaca taaatttacg     8160

ttctcagcaa ctgttatttc tctctgatca ttaattatat gtaaaataat atacattcag     8220

ttattaagaa ataaactgct ttcttaatac aaaaaaaa                             8258


<210>  16
<211>  2644
<212>  PRT
<213>  Homo sapiens

<400>  16

Met Gly Glu His Gly Leu Glu Leu Ala Ser Met Ile Pro Ala Leu Arg 
1               5                   10                  15      


Glu Leu Gly Ser Ala Thr Pro Glu Glu Tyr Asn Thr Val Val Gln Lys 
            20                  25                  30          


Pro Arg Gln Ile Leu Cys Gln Phe Ile Asp Arg Ile Leu Thr Asp Val 
        35                  40                  45              


Asn Val Val Ala Val Glu Leu Val Lys Lys Thr Asp Ser Gln Pro Thr 
    50                  55                  60                  


Ser Val Met Leu Leu Asp Phe Ile Gln His Ile Met Lys Ser Ser Pro 
65                  70                  75                  80  


Leu Met Phe Val Asn Val Ser Gly Ser His Glu Ala Lys Gly Ser Cys 
                85                  90                  95      


Ile Glu Phe Ser Asn Trp Ile Ile Thr Arg Leu Leu Arg Ile Ala Ala 
            100                 105                 110         


Thr Pro Ser Cys His Leu Leu His Lys Lys Ile Cys Glu Val Ile Cys 
        115                 120                 125             


Ser Leu Leu Phe Leu Phe Lys Ser Lys Ser Pro Ala Ile Phe Gly Val 
    130                 135                 140                 


Leu Thr Lys Glu Leu Leu Gln Leu Phe Glu Asp Leu Val Tyr Leu His 
145                 150                 155                 160 


Arg Arg Asn Val Met Gly His Ala Val Glu Trp Pro Val Val Met Ser 
                165                 170                 175     


Arg Phe Leu Ser Gln Leu Asp Glu His Met Gly Tyr Leu Gln Ser Ala 
            180                 185                 190         


Pro Leu Gln Leu Met Ser Met Gln Asn Leu Glu Phe Ile Glu Val Thr 
        195                 200                 205             


Leu Leu Met Val Leu Thr Arg Ile Ile Ala Ile Val Phe Phe Arg Arg 
    210                 215                 220                 


Gln Glu Leu Leu Leu Trp Gln Ile Gly Cys Val Leu Leu Glu Tyr Gly 
225                 230                 235                 240 


Ser Pro Lys Ile Lys Ser Leu Ala Ile Ser Phe Leu Thr Glu Leu Phe 
                245                 250                 255     


Gln Leu Gly Gly Leu Pro Ala Gln Pro Ala Ser Thr Phe Phe Ser Ser 
            260                 265                 270         


Phe Leu Glu Leu Leu Lys His Leu Val Glu Met Asp Thr Asp Gln Leu 
        275                 280                 285             


Lys Leu Tyr Glu Glu Pro Leu Ser Lys Leu Ile Lys Thr Leu Phe Pro 
    290                 295                 300                 


Phe Glu Ala Glu Ala Tyr Arg Asn Ile Glu Pro Val Tyr Leu Asn Met 
305                 310                 315                 320 


Leu Leu Glu Lys Leu Cys Val Met Phe Glu Asp Gly Val Leu Met Arg 
                325                 330                 335     


Leu Lys Ser Asp Leu Leu Lys Ala Ala Leu Cys His Leu Leu Gln Tyr 
            340                 345                 350         


Phe Leu Lys Phe Val Pro Ala Gly Tyr Glu Ser Ala Leu Gln Val Arg 
        355                 360                 365             


Lys Val Tyr Val Arg Asn Ile Cys Lys Ala Leu Leu Asp Val Leu Gly 
    370                 375                 380                 


Ile Glu Val Asp Ala Glu Tyr Leu Leu Gly Pro Leu Tyr Ala Ala Leu 
385                 390                 395                 400 


Lys Met Glu Ser Met Glu Ile Ile Glu Glu Ile Gln Cys Gln Thr Gln 
                405                 410                 415     


Gln Glu Asn Leu Ser Ser Asn Ser Asp Gly Ile Ser Pro Lys Arg Arg 
            420                 425                 430         


Arg Leu Ser Ser Ser Leu Asn Pro Ser Lys Arg Ala Pro Lys Gln Thr 
        435                 440                 445             


Glu Glu Ile Lys His Val Asp Met Asn Gln Lys Ser Ile Leu Trp Ser 
    450                 455                 460                 


Ala Leu Lys Gln Lys Ala Glu Ser Leu Gln Ile Ser Leu Glu Tyr Ser 
465                 470                 475                 480 


Gly Leu Lys Asn Pro Val Ile Glu Met Leu Glu Gly Ile Ala Val Val 
                485                 490                 495     


Leu Gln Leu Thr Ala Leu Cys Thr Val His Cys Ser His Gln Asn Met 
            500                 505                 510         


Asn Cys Arg Thr Phe Lys Asp Cys Gln His Lys Ser Lys Lys Lys Pro 
        515                 520                 525             


Ser Val Val Ile Thr Trp Met Ser Leu Asp Phe Tyr Thr Lys Val Leu 
    530                 535                 540                 


Lys Ser Cys Arg Ser Leu Leu Glu Ser Val Gln Lys Leu Asp Leu Glu 
545                 550                 555                 560 


Ala Thr Ile Asp Lys Val Val Lys Ile Tyr Asp Ala Leu Ile Tyr Met 
                565                 570                 575     


Gln Val Asn Ser Ser Phe Glu Asp His Ile Leu Glu Asp Leu Cys Gly 
            580                 585                 590         


Met Leu Ser Leu Pro Trp Ile Tyr Ser His Ser Asp Asp Gly Cys Leu 
        595                 600                 605             


Lys Leu Thr Thr Phe Ala Ala Asn Leu Leu Thr Leu Ser Cys Arg Ile 
    610                 615                 620                 


Ser Asp Ser Tyr Ser Pro Gln Ala Gln Ser Arg Cys Val Phe Leu Leu 
625                 630                 635                 640 


Thr Leu Phe Pro Arg Arg Ile Phe Leu Glu Trp Arg Thr Ala Val Tyr 
                645                 650                 655     


Asn Trp Ala Leu Gln Ser Ser His Glu Val Ile Arg Ala Ser Cys Val 
            660                 665                 670         


Ser Gly Phe Phe Ile Leu Leu Gln Gln Gln Asn Ser Cys Asn Arg Val 
        675                 680                 685             


Pro Lys Ile Leu Ile Asp Lys Val Lys Asp Asp Ser Asp Ile Val Lys 
    690                 695                 700                 


Lys Glu Phe Ala Ser Ile Leu Gly Gln Leu Val Cys Thr Leu His Gly 
705                 710                 715                 720 


Met Phe Tyr Leu Thr Ser Ser Leu Thr Glu Pro Phe Ser Glu His Gly 
                725                 730                 735     


His Val Asp Leu Phe Cys Arg Asn Leu Lys Ala Thr Ser Gln His Glu 
            740                 745                 750         


Cys Ser Ser Ser Gln Leu Lys Ala Ser Val Cys Lys Pro Phe Leu Phe 
        755                 760                 765             


Leu Leu Lys Lys Lys Ile Pro Ser Pro Val Lys Leu Ala Phe Ile Asp 
    770                 775                 780                 


Asn Leu His His Leu Cys Lys His Leu Asp Phe Arg Glu Asp Glu Thr 
785                 790                 795                 800 


Asp Val Lys Ala Val Leu Gly Thr Leu Leu Asn Leu Met Glu Asp Pro 
                805                 810                 815     


Asp Lys Asp Val Arg Val Ala Phe Ser Gly Asn Ile Lys His Ile Leu 
            820                 825                 830         


Glu Ser Leu Asp Ser Glu Asp Gly Phe Ile Lys Glu Leu Phe Val Leu 
        835                 840                 845             


Arg Met Lys Glu Ala Tyr Thr His Ala Gln Ile Ser Arg Asn Asn Glu 
    850                 855                 860                 


Leu Lys Asp Thr Leu Ile Leu Thr Thr Gly Asp Ile Gly Arg Ala Ala 
865                 870                 875                 880 


Lys Gly Asp Leu Val Pro Phe Ala Leu Leu His Leu Leu His Cys Leu 
                885                 890                 895     


Leu Ser Lys Ser Ala Ser Val Ser Gly Ala Ala Tyr Thr Glu Ile Arg 
            900                 905                 910         


Ala Leu Val Ala Ala Lys Ser Val Lys Leu Gln Ser Phe Phe Ser Gln 
        915                 920                 925             


Tyr Lys Lys Pro Ile Cys Gln Phe Leu Val Glu Ser Leu His Ser Ser 
    930                 935                 940                 


Gln Met Thr Ala Leu Pro Asn Thr Pro Cys Gln Asn Ala Asp Val Arg 
945                 950                 955                 960 


Lys Gln Asp Val Ala His Gln Arg Glu Met Ala Leu Asn Thr Leu Ser 
                965                 970                 975     


Glu Ile Ala Asn Val Phe Asp Phe Pro Asp Leu Asn Arg Phe Leu Thr 
            980                 985                 990         


Arg Thr Leu Gln Val Leu Leu Pro  Asp Leu Ala Ala Lys  Ala Ser Pro 
        995                 1000                 1005             


Ala Ala  Ser Ala Leu Ile Arg  Thr Leu Gly Lys Gln  Leu Asn Val 
    1010                 1015                 1020             


Asn Arg  Arg Glu Ile Leu Ile  Asn Asn Phe Lys Tyr  Ile Phe Ser 
    1025                 1030                 1035             


His Leu  Val Cys Ser Cys Ser  Lys Asp Glu Leu Glu  Arg Ala Leu 
    1040                 1045                 1050             


His Tyr  Leu Lys Asn Glu Thr  Glu Ile Glu Leu Gly  Ser Leu Leu 
    1055                 1060                 1065             


Arg Gln  Asp Phe Gln Gly Leu  His Asn Glu Leu Leu  Leu Arg Ile 
    1070                 1075                 1080             


Gly Glu  His Tyr Gln Gln Val  Phe Asn Gly Leu Ser  Ile Leu Ala 
    1085                 1090                 1095             


Ser Phe  Ala Ser Ser Asp Asp  Pro Tyr Gln Gly Pro  Arg Asp Ile 
    1100                 1105                 1110             


Ile Ser  Pro Glu Leu Met Ala  Asp Tyr Leu Gln Pro  Lys Leu Leu 
    1115                 1120                 1125             


Gly Ile  Leu Ala Phe Phe Asn  Met Gln Leu Leu Ser  Ser Ser Val 
    1130                 1135                 1140             


Gly Ile  Glu Asp Lys Lys Met  Ala Leu Asn Ser Leu  Met Ser Leu 
    1145                 1150                 1155             


Met Lys  Leu Met Gly Pro Lys  His Val Ser Ser Val  Arg Val Lys 
    1160                 1165                 1170             


Met Met  Thr Thr Leu Arg Thr  Gly Leu Arg Phe Lys  Asp Asp Phe 
    1175                 1180                 1185             


Pro Glu  Leu Cys Cys Arg Ala  Trp Asp Cys Phe Val  Arg Cys Leu 
    1190                 1195                 1200             


Asp His  Ala Cys Leu Gly Ser  Leu Leu Ser His Val  Ile Val Ala 
    1205                 1210                 1215             


Leu Leu  Pro Leu Ile His Ile  Gln Pro Lys Glu Thr  Ala Ala Ile 
    1220                 1225                 1230             


Phe His  Tyr Leu Ile Ile Glu  Asn Arg Asp Ala Val  Gln Asp Phe 
    1235                 1240                 1245             


Leu His  Glu Ile Tyr Phe Leu  Pro Asp His Pro Glu  Leu Lys Lys 
    1250                 1255                 1260             


Ile Lys  Ala Val Leu Gln Glu  Tyr Arg Lys Glu Thr  Ser Glu Ser 
    1265                 1270                 1275             


Thr Asp  Leu Gln Thr Thr Leu  Gln Leu Ser Met Lys  Ala Ile Gln 
    1280                 1285                 1290             


His Glu  Asn Val Asp Val Arg  Ile His Ala Leu Thr  Ser Leu Lys 
    1295                 1300                 1305             


Glu Thr  Leu Tyr Lys Asn Gln  Glu Lys Leu Ile Lys  Tyr Ala Thr 
    1310                 1315                 1320             


Asp Ser  Glu Thr Val Glu Pro  Ile Ile Ser Gln Leu  Val Thr Val 
    1325                 1330                 1335             


Leu Leu  Lys Gly Cys Gln Asp  Ala Asn Ser Gln Ala  Arg Leu Leu 
    1340                 1345                 1350             


Cys Gly  Glu Cys Leu Gly Glu  Leu Gly Ala Ile Asp  Pro Gly Arg 
    1355                 1360                 1365             


Leu Asp  Phe Ser Thr Thr Glu  Thr Gln Gly Lys Asp  Phe Thr Phe 
    1370                 1375                 1380             


Val Thr  Gly Val Glu Asp Ser  Ser Phe Ala Tyr Gly  Leu Leu Met 
    1385                 1390                 1395             


Glu Leu  Thr Arg Ala Tyr Leu  Ala Tyr Ala Asp Asn  Ser Arg Ala 
    1400                 1405                 1410             


Gln Asp  Ser Ala Ala Tyr Ala  Ile Gln Glu Leu Leu  Ser Ile Tyr 
    1415                 1420                 1425             


Asp Cys  Arg Glu Met Glu Thr  Asn Gly Pro Gly His  Gln Leu Trp 
    1430                 1435                 1440             


Arg Arg  Phe Pro Glu His Val  Arg Glu Ile Leu Glu  Pro His Leu 
    1445                 1450                 1455             


Asn Thr  Arg Tyr Lys Ser Ser  Gln Lys Ser Thr Asp  Trp Ser Gly 
    1460                 1465                 1470             


Val Lys  Lys Pro Ile Tyr Leu  Ser Lys Leu Gly Ser  Asn Phe Ala 
    1475                 1480                 1485             


Glu Trp  Ser Ala Ser Trp Ala  Gly Tyr Leu Ile Thr  Lys Val Arg 
    1490                 1495                 1500             


His Asp  Leu Ala Ser Lys Ile  Phe Thr Cys Cys Ser  Ile Met Met 
    1505                 1510                 1515             


Lys His  Asp Phe Lys Val Thr  Ile Tyr Leu Leu Pro  His Ile Leu 
    1520                 1525                 1530             


Val Tyr  Val Leu Leu Gly Cys  Asn Gln Glu Asp Gln  Gln Glu Val 
    1535                 1540                 1545             


Tyr Ala  Glu Ile Met Ala Val  Leu Lys His Asp Asp  Gln His Thr 
    1550                 1555                 1560             


Ile Asn  Thr Gln Asp Ile Ala  Ser Asp Leu Cys Gln  Leu Ser Thr 
    1565                 1570                 1575             


Gln Thr  Val Phe Ser Met Leu  Asp His Leu Thr Gln  Trp Ala Arg 
    1580                 1585                 1590             


His Lys  Phe Gln Ala Leu Lys  Ala Glu Lys Cys Pro  His Ser Lys 
    1595                 1600                 1605             


Ser Asn  Arg Asn Lys Val Asp  Ser Met Val Ser Thr  Val Asp Tyr 
    1610                 1615                 1620             


Glu Asp  Tyr Gln Ser Val Thr  Arg Phe Leu Asp Leu  Ile Pro Gln 
    1625                 1630                 1635             


Asp Thr  Leu Ala Val Ala Ser  Phe Arg Ser Lys Ala  Tyr Thr Arg 
    1640                 1645                 1650             


Ala Val  Met His Phe Glu Ser  Phe Ile Thr Glu Lys  Lys Gln Asn 
    1655                 1660                 1665             


Ile Gln  Glu His Leu Gly Phe  Leu Gln Lys Leu Tyr  Ala Ala Met 
    1670                 1675                 1680             


His Glu  Pro Asp Gly Val Ala  Gly Val Ser Ala Ile  Arg Lys Ala 
    1685                 1690                 1695             


Glu Pro  Ser Leu Lys Glu Gln  Ile Leu Glu His Glu  Ser Leu Gly 
    1700                 1705                 1710             


Leu Leu  Arg Asp Ala Thr Ala  Cys Tyr Asp Arg Ala  Ile Gln Leu 
    1715                 1720                 1725             


Glu Pro  Asp Gln Ile Ile His  Tyr His Gly Val Val  Lys Ser Met 
    1730                 1735                 1740             


Leu Gly  Leu Gly Gln Leu Ser  Thr Val Ile Thr Gln  Val Asn Gly 
    1745                 1750                 1755             


Val His  Ala Asn Arg Ser Glu  Trp Thr Asp Glu Leu  Asn Thr Tyr 
    1760                 1765                 1770             


Arg Val  Glu Ala Ala Trp Lys  Leu Ser Gln Trp Asp  Leu Val Glu 
    1775                 1780                 1785             


Asn Tyr  Leu Ala Ala Asp Gly  Lys Ser Thr Thr Trp  Ser Val Arg 
    1790                 1795                 1800             


Leu Gly  Gln Leu Leu Leu Ser  Ala Lys Lys Arg Asp  Ile Thr Ala 
    1805                 1810                 1815             


Phe Tyr  Asp Ser Leu Lys Leu  Val Arg Ala Glu Gln  Ile Val Pro 
    1820                 1825                 1830             


Leu Ser  Ala Ala Ser Phe Glu  Arg Gly Ser Tyr Gln  Arg Gly Tyr 
    1835                 1840                 1845             


Glu Tyr  Ile Val Arg Leu His  Met Leu Cys Glu Leu  Glu His Ser 
    1850                 1855                 1860             


Ile Lys  Pro Leu Phe Gln His  Ser Pro Gly Asp Ser  Ser Gln Glu 
    1865                 1870                 1875             


Asp Ser  Leu Asn Trp Val Ala  Arg Leu Glu Met Thr  Gln Asn Ser 
    1880                 1885                 1890             


Tyr Arg  Ala Lys Glu Pro Ile  Leu Ala Leu Arg Arg  Ala Leu Leu 
    1895                 1900                 1905             


Ser Leu  Asn Lys Arg Pro Asp  Tyr Asn Glu Met Val  Gly Glu Cys 
    1910                 1915                 1920             


Trp Leu  Gln Ser Ala Arg Val  Ala Arg Lys Ala Gly  His His Gln 
    1925                 1930                 1935             


Thr Ala  Tyr Asn Ala Leu Leu  Asn Ala Gly Glu Ser  Arg Leu Ala 
    1940                 1945                 1950             


Glu Leu  Tyr Val Glu Arg Ala  Lys Trp Leu Trp Ser  Lys Gly Asp 
    1955                 1960                 1965             


Val His  Gln Ala Leu Ile Val  Leu Gln Lys Gly Val  Glu Leu Cys 
    1970                 1975                 1980             


Phe Pro  Glu Asn Glu Thr Pro  Pro Glu Gly Lys Asn  Met Leu Ile 
    1985                 1990                 1995             


His Gly  Arg Ala Met Leu Leu  Val Gly Arg Phe Met  Glu Glu Thr 
    2000                 2005                 2010             


Ala Asn  Phe Glu Ser Asn Ala  Ile Met Lys Lys Tyr  Lys Asp Val 
    2015                 2020                 2025             


Thr Ala  Cys Leu Pro Glu Trp  Glu Asp Gly His Phe  Tyr Leu Ala 
    2030                 2035                 2040             


Lys Tyr  Tyr Asp Lys Leu Met  Pro Met Val Thr Asp  Asn Lys Met 
    2045                 2050                 2055             


Glu Lys  Gln Gly Asp Leu Ile  Arg Tyr Ile Val Leu  His Phe Gly 
    2060                 2065                 2070             


Arg Ser  Leu Gln Tyr Gly Asn  Gln Phe Ile Tyr Gln  Ser Met Pro 
    2075                 2080                 2085             


Arg Met  Leu Thr Leu Trp Leu  Asp Tyr Gly Thr Lys  Ala Tyr Glu 
    2090                 2095                 2100             


Trp Glu  Lys Ala Gly Arg Ser  Asp Arg Val Gln Met  Arg Asn Asp 
    2105                 2110                 2115             


Leu Gly  Lys Ile Asn Lys Val  Ile Thr Glu His Thr  Asn Tyr Leu 
    2120                 2125                 2130             


Ala Pro  Tyr Gln Phe Leu Thr  Ala Phe Ser Gln Leu  Ile Ser Arg 
    2135                 2140                 2145             


Ile Cys  His Ser His Asp Glu  Val Phe Val Val Leu  Met Glu Ile 
    2150                 2155                 2160             


Ile Ala  Lys Val Phe Leu Ala  Tyr Pro Gln Gln Ala  Met Trp Met 
    2165                 2170                 2175             


Met Thr  Ala Val Ser Lys Ser  Ser Tyr Pro Met Arg  Val Asn Arg 
    2180                 2185                 2190             


Cys Lys  Glu Ile Leu Asn Lys  Ala Ile His Met Lys  Lys Ser Leu 
    2195                 2200                 2205             


Glu Lys  Phe Val Gly Asp Ala  Thr Arg Leu Thr Asp  Lys Leu Leu 
    2210                 2215                 2220             


Glu Leu  Cys Asn Lys Pro Val  Asp Gly Ser Ser Ser  Thr Leu Ser 
    2225                 2230                 2235             


Met Ser  Thr His Phe Lys Met  Leu Lys Lys Leu Val  Glu Glu Ala 
    2240                 2245                 2250             


Thr Phe  Ser Glu Ile Leu Ile  Pro Leu Gln Ser Val  Met Ile Pro 
    2255                 2260                 2265             


Thr Leu  Pro Ser Ile Leu Gly  Thr His Ala Asn His  Ala Ser His 
    2270                 2275                 2280             


Glu Pro  Phe Pro Gly His Trp  Ala Tyr Ile Ala Gly  Phe Asp Asp 
    2285                 2290                 2295             


Met Val  Glu Ile Leu Ala Ser  Leu Gln Lys Pro Lys  Lys Ile Ser 
    2300                 2305                 2310             


Leu Lys  Gly Ser Asp Gly Lys  Phe Tyr Ile Met Met  Cys Lys Pro 
    2315                 2320                 2325             


Lys Asp  Asp Leu Arg Lys Asp  Cys Arg Leu Met Glu  Phe Asn Ser 
    2330                 2335                 2340             


Leu Ile  Asn Lys Cys Leu Arg  Lys Asp Ala Glu Ser  Arg Arg Arg 
    2345                 2350                 2355             


Glu Leu  His Ile Arg Thr Tyr  Ala Val Ile Pro Leu  Asn Asp Glu 
    2360                 2365                 2370             


Cys Gly  Ile Ile Glu Trp Val  Asn Asn Thr Ala Gly  Leu Arg Pro 
    2375                 2380                 2385             


Ile Leu  Thr Lys Leu Tyr Lys  Glu Lys Gly Val Tyr  Met Thr Gly 
    2390                 2395                 2400             


Lys Glu  Leu Arg Gln Cys Met  Leu Pro Lys Ser Ala  Ala Leu Ser 
    2405                 2410                 2415             


Glu Lys  Leu Lys Val Phe Arg  Glu Phe Leu Leu Pro  Arg His Pro 
    2420                 2425                 2430             


Pro Ile  Phe His Glu Trp Phe  Leu Arg Thr Phe Pro  Asp Pro Thr 
    2435                 2440                 2445             


Ser Trp  Tyr Ser Ser Arg Ser  Ala Tyr Cys Arg Ser  Thr Ala Val 
    2450                 2455                 2460             


Met Ser  Met Val Gly Tyr Ile  Leu Gly Leu Gly Asp  Arg His Gly 
    2465                 2470                 2475             


Glu Asn  Ile Leu Phe Asp Ser  Leu Thr Gly Glu Cys  Val His Val 
    2480                 2485                 2490             


Asp Phe  Asn Cys Leu Phe Asn  Lys Gly Glu Thr Phe  Glu Val Pro 
    2495                 2500                 2505             


Glu Ile  Val Pro Phe Arg Leu  Thr His Asn Met Val  Asn Gly Met 
    2510                 2515                 2520             


Gly Pro  Met Gly Thr Glu Gly  Leu Phe Arg Arg Ala  Cys Glu Val 
    2525                 2530                 2535             


Thr Met  Arg Leu Met Arg Asp  Gln Arg Glu Pro Leu  Met Ser Val 
    2540                 2545                 2550             


Leu Lys  Thr Phe Leu His Asp  Pro Leu Val Glu Trp  Ser Lys Pro 
    2555                 2560                 2565             


Val Lys  Gly His Ser Lys Ala  Pro Leu Asn Glu Thr  Gly Glu Val 
    2570                 2575                 2580             


Val Asn  Glu Lys Ala Lys Thr  His Val Leu Asp Ile  Glu Gln Arg 
    2585                 2590                 2595             


Leu Gln  Gly Val Ile Lys Thr  Arg Asn Arg Val Thr  Gly Leu Pro 
    2600                 2605                 2610             


Leu Ser  Ile Glu Gly His Val  His Tyr Leu Ile Gln  Glu Ala Thr 
    2615                 2620                 2625             


Asp Glu  Asn Leu Leu Cys Gln  Met Tyr Leu Gly Trp  Thr Pro Tyr 
    2630                 2635                 2640             


Met 
    


<210>  17
<211>  19
<212>  RNA
<213>  Artificial sequence

<220>
<223>  siRNA oligonucleotide

<400>  17
aauagaacau cucgacuua                                                    19


<210>  18
<211>  19
<212>  RNA
<213>  Artificial sequence

<220>
<223>  siRNA oligonucleotide

<400>  18
aauaugaagu cccgguaua                                                    19


<210>  19
<211>  19
<212>  RNA
<213>  Artificial sequence

<220>
<223>  siRNA oligonucleotide

<400>  19
gaucauaugc uuauacaga                                                    19


<210>  20
<211>  19
<212>  RNA
<213>  Artificial sequence

<220>
<223>  siRNA oligonucleotide

<400>  20
cgacagacuc cucaaguga                                                    19


<210>  21
<211>  25
<212>  RNA
<213>  Artificial sequence

<220>
<223>  siRNA oligonucleotide

<400>  21
ggcuuggcaa caguauuucg guaua                                             25


<210>  22
<211>  25
<212>  RNA
<213>  Artificial sequence

<220>
<223>  siRNA oligonucleotide

<400>  22
gggaaauacu agaaccucau cuaaa                                             25


<210>  23
<211>  25
<212>  RNA
<213>  Artificial sequence

<220>
<223>  siRNA oligonucleotide

<400>  23
gcgcagugua gcuacuucuu cuauu                                             25


<210>  24
<211>  19
<212>  RNA
<213>  Artificial sequence

<220>
<223>  siRNA oligonucleotide

<400>  24
guaagaaagu agccauaaa                                                    19


<210>  25
<211>  19
<212>  RNA
<213>  Artificial sequence

<220>
<223>  siRNA oligonucleotide

<400>  25
gcauaggacu caaguguca                                                    19


<210>  26
<211>  19
<212>  RNA
<213>  Artificial sequence

<220>
<223>  siRNA oligonucleotide

<400>  26
guugugaacu ccgugguuu                                                    19


<210>  27
<211>  19
<212>  RNA
<213>  Artificial sequence

<220>
<223>  siRNA oligonucleotide

<400>  27
cucaggaacu cuauucuau                                                    19


<210>  28
<211>  19
<212>  RNA
<213>  Artificial sequence

<220>
<223>  siRNA oligonucleotide

<400>  28
gaaaccgucu ccagucugu                                                    19


<210>  29
<211>  19
<212>  RNA
<213>  Artificial sequence

<220>
<223>  siRNA oligonucleotide

<400>  29
uaaaggaggu auaucgaau                                                    19


<210>  30
<211>  3195
<212>  DNA
<213>  Homo sapiens

<400>  30
atggcttctg agtctgaaac tctgaatccc agtgctagga taatgacctt ttatccaact       60

atggaagagt tccgaaactt cagtagatac attgcctaca ttgaatccca aggagctcat      120

cgggcagggc tagccaaggt tgttcctcca aaagagtgga agccacgagc atcctatgat      180

gacattgatg atttggtcat tcctgccccc attcaacagc tggtgacggg gcagtctggc      240

ctctttactc agtacaacat acagaagaaa gccatgactg ttcgagagtt ccgcaagata      300

gccaatagcg ataagtactg taccccacgc tatagtgagt ttgaagagct cgagcggaaa      360

tactggaaaa atcttacatt caatcctcca atctatggtg cagatgtgaa tggtaccctc      420

tatgaaaagc atgttgatga gtggaatatt ggccggctga gaacaatcct ggacttggtg      480

gaaaaggaga gtgggatcac cattgagggt gtgaacaccc catacctgta ctttggcatg      540

tggaagacat cctttgcttg gcacactgaa gacatggacc tctacagcat caactacctg      600

cactttggag aaccaaagtc ctggtactct gttccacctg agcatggaaa gcggttggaa      660

cgcctcgcca aaggcttttt cccaggaagt gctcaaagct gtgaggcatt tctccgccac      720

aagatgaccc tgatttcccc gttaatgctg aagaaatatg gaattccctt tgacaaggtg      780

actcaagagg ctggagagtt tatgatcact ttcccttatg gttaccatgc cggctttaac      840

catggtttta actgtgcgga gtctaccaat tttgctaccc gtcggtggat tgagtacggc      900

aagcaagctg tgctgtgctc ctgtagaaag gacatggtga agatctccat ggatgtgttt      960

gtgagaaagt tccagccaga aaggtacaaa ctttggaaag ctgggaagga caacacagtt     1020

attgaccata ctctgcccac gccagaagca gctgagtttc ttaaggagag tgaactgcct     1080

ccaagagctg gcaacgagga ggagtgccca gaggaggaca tggaaggggt ggaggatgga     1140

gaggaaggag acctgaagac aagcctggcc aagcaccgaa tagggacaaa gaggcaccga     1200

gtttgtcttg aaataccaca ggaggtgagt cagagtgagc tcttccccaa ggaggatctg     1260

agttctgagc agtatgagat gacggagtgc ccggcagccc tcgcccctgt gaggcccacc     1320

catagctctg tgcggcaagt tgaggatggt cttaccttcc cagattattc tgactccact     1380

gaagtcaaat ttgaagagct taaaaatgtc aaactagaag aggaggatga ggaggaagaa     1440

caagcagcag ctgccttgga tctttctgtg aatcctgcgt ctgtaggggg acgccttgtc     1500

ttctcaggct ccaaaaagaa atcatcttct agcctgggct ctggctcttc acgggattct     1560

atctcttctg attcagaaac tagtgagcct ctctcctgcc gagcccaagg gcaaacggga     1620

gttctcactg tgcacagtta tgccaaaggg gatggcaggg tcactgtggg agagccatgc     1680

acgaggaaga aaggaagcgc cgctagaagt ttcagtgagc gggagctggc agaggttgca     1740

gatgaataca tgttttccct agaagagaat aagaagtcca agggacgccg tcagccttta     1800

agcaagctcc cccgccatca cccacttgtg ctgcaggagt gtgtcagtga tgatgagaca     1860

tctgaacagc tgacccctga ggaagaggct gaggagacag aggcctgggc caagcctctg     1920

agccaactgt ggcagaaccg acctccaaac tttgaggctg agaaggaatt caatgagacc     1980

atggcccaac aggcccctca ctgcgctgtc tgtatgatct tccagactta tcatcaggtt     2040

gaatttggag gctttaatca gaactgtgga aatgcttcag atttagcccc ccagaagcag     2100

aggaccaagc cattgattcc agaaatgtgc ttcacttcga ctggctgcag cacggacatc     2160

aacctttcta ctccttatct tgaggaggat ggcaccagca tactcgtttc ctgcaagaag     2220

tgcagcgtcc gggtccatgc cagttgctat ggggtccccc ctgcaaaggc ttctgaagac     2280

tggatgtgtt ctcggtgttc agccaatgcc ctagaggagg actgctgttt atgctcatta     2340

cgaggagggg ccctgcagag agcaaatgat gacaggtggg tccacgtttc atgtgctgtg     2400

gcaattctgg aagcaaggtt tgtcaacatt gcagaaagaa gtccggtgga tgtgagcaaa     2460

atccccctgc cccgcttcaa actgaaatgt atcttctgta agaagcggag gaaaagaact     2520

gctggctgct gtgtgcagtg ttctcacggc cgctgcccaa ctgccttcca tgtgagctgc     2580

gcccaggctg ccggtgtgat gatgcagcct gacgactggc cttttgtggt cttcattacc     2640

tgctttcggc acaagattcc taatttggag cgtgccaagg gggccttgca aagcatcact     2700

gcaggccaga aagtcattag caagcataag aacgggcgct tctaccagtg tgaagtggtc     2760

aggctcacca ccgagacctt ctatgaagtc aactttgatg atggctcctt cagcgacaat     2820

ctttatcctg aggacatagt gagccaggac tgtctccagt ttggtcctcc tgctgaaggg     2880

gaagtggtcc aagtgagatg gacagacggc caagtctatg gagccaagtt tgtggcctcc     2940

caccctatcc aaatgtacca ggtggagttt gaggatggct cacaacttgt ggttaagaga     3000

gatgatgtat acacactgga tgaagagctt cccaagagag tcaaatctag actgtcagta     3060

gcctcagaca tgcgcttcaa tgagattttc acagagaaag aggttaagca agaaaagaaa     3120

cggcaacgag ttatcaactc aagataccgg gaagattata ttgagcctgc actataccgg     3180

gccatcatgg agtag                                                      3195


<210>  31
<211>  1064
<212>  PRT
<213>  Homo sapiens

<400>  31

Met Ala Ser Glu Ser Glu Thr Leu Asn Pro Ser Ala Arg Ile Met Thr 
1               5                   10                  15      


Phe Tyr Pro Thr Met Glu Glu Phe Arg Asn Phe Ser Arg Tyr Ile Ala 
            20                  25                  30          


Tyr Ile Glu Ser Gln Gly Ala His Arg Ala Gly Leu Ala Lys Val Val 
        35                  40                  45              


Pro Pro Lys Glu Trp Lys Pro Arg Ala Ser Tyr Asp Asp Ile Asp Asp 
    50                  55                  60                  


Leu Val Ile Pro Ala Pro Ile Gln Gln Leu Val Thr Gly Gln Ser Gly 
65                  70                  75                  80  


Leu Phe Thr Gln Tyr Asn Ile Gln Lys Lys Ala Met Thr Val Arg Glu 
                85                  90                  95      


Phe Arg Lys Ile Ala Asn Ser Asp Lys Tyr Cys Thr Pro Arg Tyr Ser 
            100                 105                 110         


Glu Phe Glu Glu Leu Glu Arg Lys Tyr Trp Lys Asn Leu Thr Phe Asn 
        115                 120                 125             


Pro Pro Ile Tyr Gly Ala Asp Val Asn Gly Thr Leu Tyr Glu Lys His 
    130                 135                 140                 


Val Asp Glu Trp Asn Ile Gly Arg Leu Arg Thr Ile Leu Asp Leu Val 
145                 150                 155                 160 


Glu Lys Glu Ser Gly Ile Thr Ile Glu Gly Val Asn Thr Pro Tyr Leu 
                165                 170                 175     


Tyr Phe Gly Met Trp Lys Thr Ser Phe Ala Trp His Thr Glu Asp Met 
            180                 185                 190         


Asp Leu Tyr Ser Ile Asn Tyr Leu His Phe Gly Glu Pro Lys Ser Trp 
        195                 200                 205             


Tyr Ser Val Pro Pro Glu His Gly Lys Arg Leu Glu Arg Leu Ala Lys 
    210                 215                 220                 


Gly Phe Phe Pro Gly Ser Ala Gln Ser Cys Glu Ala Phe Leu Arg His 
225                 230                 235                 240 


Lys Met Thr Leu Ile Ser Pro Leu Met Leu Lys Lys Tyr Gly Ile Pro 
                245                 250                 255     


Phe Asp Lys Val Thr Gln Glu Ala Gly Glu Phe Met Ile Thr Phe Pro 
            260                 265                 270         


Tyr Gly Tyr His Ala Gly Phe Asn His Gly Phe Asn Cys Ala Glu Ser 
        275                 280                 285             


Thr Asn Phe Ala Thr Arg Arg Trp Ile Glu Tyr Gly Lys Gln Ala Val 
    290                 295                 300                 


Leu Cys Ser Cys Arg Lys Asp Met Val Lys Ile Ser Met Asp Val Phe 
305                 310                 315                 320 


Val Arg Lys Phe Gln Pro Glu Arg Tyr Lys Leu Trp Lys Ala Gly Lys 
                325                 330                 335     


Asp Asn Thr Val Ile Asp His Thr Leu Pro Thr Pro Glu Ala Ala Glu 
            340                 345                 350         


Phe Leu Lys Glu Ser Glu Leu Pro Pro Arg Ala Gly Asn Glu Glu Glu 
        355                 360                 365             


Cys Pro Glu Glu Asp Met Glu Gly Val Glu Asp Gly Glu Glu Gly Asp 
    370                 375                 380                 


Leu Lys Thr Ser Leu Ala Lys His Arg Ile Gly Thr Lys Arg His Arg 
385                 390                 395                 400 


Val Cys Leu Glu Ile Pro Gln Glu Val Ser Gln Ser Glu Leu Phe Pro 
                405                 410                 415     


Lys Glu Asp Leu Ser Ser Glu Gln Tyr Glu Met Thr Glu Cys Pro Ala 
            420                 425                 430         


Ala Leu Ala Pro Val Arg Pro Thr His Ser Ser Val Arg Gln Val Glu 
        435                 440                 445             


Asp Gly Leu Thr Phe Pro Asp Tyr Ser Asp Ser Thr Glu Val Lys Phe 
    450                 455                 460                 


Glu Glu Leu Lys Asn Val Lys Leu Glu Glu Glu Asp Glu Glu Glu Glu 
465                 470                 475                 480 


Gln Ala Ala Ala Ala Leu Asp Leu Ser Val Asn Pro Ala Ser Val Gly 
                485                 490                 495     


Gly Arg Leu Val Phe Ser Gly Ser Lys Lys Lys Ser Ser Ser Ser Leu 
            500                 505                 510         


Gly Ser Gly Ser Ser Arg Asp Ser Ile Ser Ser Asp Ser Glu Thr Ser 
        515                 520                 525             


Glu Pro Leu Ser Cys Arg Ala Gln Gly Gln Thr Gly Val Leu Thr Val 
    530                 535                 540                 


His Ser Tyr Ala Lys Gly Asp Gly Arg Val Thr Val Gly Glu Pro Cys 
545                 550                 555                 560 


Thr Arg Lys Lys Gly Ser Ala Ala Arg Ser Phe Ser Glu Arg Glu Leu 
                565                 570                 575     


Ala Glu Val Ala Asp Glu Tyr Met Phe Ser Leu Glu Glu Asn Lys Lys 
            580                 585                 590         


Ser Lys Gly Arg Arg Gln Pro Leu Ser Lys Leu Pro Arg His His Pro 
        595                 600                 605             


Leu Val Leu Gln Glu Cys Val Ser Asp Asp Glu Thr Ser Glu Gln Leu 
    610                 615                 620                 


Thr Pro Glu Glu Glu Ala Glu Glu Thr Glu Ala Trp Ala Lys Pro Leu 
625                 630                 635                 640 


Ser Gln Leu Trp Gln Asn Arg Pro Pro Asn Phe Glu Ala Glu Lys Glu 
                645                 650                 655     


Phe Asn Glu Thr Met Ala Gln Gln Ala Pro His Cys Ala Val Cys Met 
            660                 665                 670         


Ile Phe Gln Thr Tyr His Gln Val Glu Phe Gly Gly Phe Asn Gln Asn 
        675                 680                 685             


Cys Gly Asn Ala Ser Asp Leu Ala Pro Gln Lys Gln Arg Thr Lys Pro 
    690                 695                 700                 


Leu Ile Pro Glu Met Cys Phe Thr Ser Thr Gly Cys Ser Thr Asp Ile 
705                 710                 715                 720 


Asn Leu Ser Thr Pro Tyr Leu Glu Glu Asp Gly Thr Ser Ile Leu Val 
                725                 730                 735     


Ser Cys Lys Lys Cys Ser Val Arg Val His Ala Ser Cys Tyr Gly Val 
            740                 745                 750         


Pro Pro Ala Lys Ala Ser Glu Asp Trp Met Cys Ser Arg Cys Ser Ala 
        755                 760                 765             


Asn Ala Leu Glu Glu Asp Cys Cys Leu Cys Ser Leu Arg Gly Gly Ala 
    770                 775                 780                 


Leu Gln Arg Ala Asn Asp Asp Arg Trp Val His Val Ser Cys Ala Val 
785                 790                 795                 800 


Ala Ile Leu Glu Ala Arg Phe Val Asn Ile Ala Glu Arg Ser Pro Val 
                805                 810                 815     


Asp Val Ser Lys Ile Pro Leu Pro Arg Phe Lys Leu Lys Cys Ile Phe 
            820                 825                 830         


Cys Lys Lys Arg Arg Lys Arg Thr Ala Gly Cys Cys Val Gln Cys Ser 
        835                 840                 845             


His Gly Arg Cys Pro Thr Ala Phe His Val Ser Cys Ala Gln Ala Ala 
    850                 855                 860                 


Gly Val Met Met Gln Pro Asp Asp Trp Pro Phe Val Val Phe Ile Thr 
865                 870                 875                 880 


Cys Phe Arg His Lys Ile Pro Asn Leu Glu Arg Ala Lys Gly Ala Leu 
                885                 890                 895     


Gln Ser Ile Thr Ala Gly Gln Lys Val Ile Ser Lys His Lys Asn Gly 
            900                 905                 910         


Arg Phe Tyr Gln Cys Glu Val Val Arg Leu Thr Thr Glu Thr Phe Tyr 
        915                 920                 925             


Glu Val Asn Phe Asp Asp Gly Ser Phe Ser Asp Asn Leu Tyr Pro Glu 
    930                 935                 940                 


Asp Ile Val Ser Gln Asp Cys Leu Gln Phe Gly Pro Pro Ala Glu Gly 
945                 950                 955                 960 


Glu Val Val Gln Val Arg Trp Thr Asp Gly Gln Val Tyr Gly Ala Lys 
                965                 970                 975     


Phe Val Ala Ser His Pro Ile Gln Met Tyr Gln Val Glu Phe Glu Asp 
            980                 985                 990         


Gly Ser Gln Leu Val Val Lys Arg  Asp Asp Val Tyr Thr  Leu Asp Glu 
        995                 1000                 1005             


Glu Leu  Pro Lys Arg Val Lys  Ser Arg Leu Ser Val  Ala Ser Asp 
    1010                 1015                 1020             


Met Arg  Phe Asn Glu Ile Phe  Thr Glu Lys Glu Val  Lys Gln Glu 
    1025                 1030                 1035             


Lys Lys  Arg Gln Arg Val Ile  Asn Ser Arg Tyr Arg  Glu Asp Tyr 
    1040                 1045                 1050             


Ile Glu  Pro Ala Leu Tyr Arg  Ala Ile Met Glu 
    1055                 1060                 


<210>  32
<211>  3291
<212>  DNA
<213>  Homo sapiens

<400>  32
atggggtctg aggaccacgg cgcccagaac cccagctgta aaatcatgac gtttcgccca       60

accatggaag aatttaaaga cttcaacaaa tacgtggcct acatagagtc gcagggagcc      120

caccgggcgg gcctggccaa gatcatcccc ccgaaggagt ggaagccgcg gcagacgtat      180

gatgacatcg acgacgtggt gatcccggcg cccatccagc aggtggtgac gggccagtcg      240

ggcctcttca cgcagtacaa tatccagaag aaggccatga cagtgggcga gtaccgccgc      300

ctggccaaca gcgagaagta ctgtaccccg cggcaccagg actttgatga ccttgaacgc      360

aaatactgga agaacctcac ctttgtctcc ccgatctacg gggctgacat cagcggctct      420

ttgtatgatg acgacgtggc ccagtggaac atcgggagcc tccggaccat cctggacatg      480

gtggagcgcg agtgcggcac catcatcgag ggcgtgaaca cgccctacct gtacttcggc      540

atgtggaaga ccaccttcgc ctggcacacc gaggacatgg acctgtacag catcaactac      600

ctgcactttg gggagcctaa gtcctggtac gccatcccac cagagcacgg caagcgcctg      660

gagcggctgg ccatcggctt cttccccggg agctcgcagg gctgcgacgc cttcctgcgg      720

cataagatga ccctcatctc gcccatcatc ctgaagaagt acgggatccc cttcagccgg      780

atcacgcagg aggccgggga attcatgatc acatttccct acggctacca cgccggcttc      840

aatcacgggt tcaactgcgc agaatctacc aacttcgcca ccctgcggtg gattgactac      900

ggcaaagtgg ccactcagtg cacgtgccgg aaggacatgg tcaagatctc catggacgtg      960

ttcgtgcgca tcctgcagcc cgagcgctac gagctgtgga agcagggcaa ggacctcacg     1020

gtgctggacc acacgcggcc cacggcgctc accagccccg agctgagctc ctggagtgca     1080

tcccgggcct cgctgaaggc caagctcctc cgcaggtctc accggaaacg gagccagccc     1140

aagaagccga agcccgaaga ccccaagttc cctggggagg gtacggctgg ggcagcgctc     1200

ctagaggagg ctgggggcag cgtgaaggag gaggctgggc cggaggttga ccccgaggag     1260

gaggaggagg agccgcagcc actgccacac ggccgggagg ccgagggcgc agaagaggac     1320

gggaggggca agctgcggcc aaccaaggcc aagagcgagc ggaagaagaa gagcttcggc     1380

ctgctgcccc cacagctgcc gcccccgcct gctcacttcc cctcagagga ggcgctgtgg     1440

ctgccatccc cactggagcc cccggtgctg ggcccaggcc ctgcagccat ggaggagagc     1500

cccctgccgg caccccttaa tgtcgtgccc cctgaggtgc ccagtgagga gctagaggcc     1560

aagcctcggc ccatcatccc catgctgtac gtggtgccgc ggccgggcaa ggcagccttc     1620

aaccaggagc acgtgtcctg ccagcaggcc tttgagcact ttgcccagaa gggtccgacc     1680

tggaaggaac cagtttcccc catggagctg acggggccag aggacggtgc agccagcagt     1740

ggggcaggtc gcatggagac caaagcccgg gccggagagg ggcaggcacc gtccacattt     1800

tccaaattga agatggagat caagaagagc cggcgccatc ccctgggccg gccgcccacc     1860

cggtccccac tgtcggtggt gaagcaggag gcctcaagtg acgaggaggc atcccctttc     1920

tccggggagg aagatgtgag tgacccggac gccttgaggc cgctgctgtc tctgcagtgg     1980

aagaacaggg cggccagctt ccaggccgag aggaagttca acgcagcggc tgcgcgcacg     2040

gagccctact gcgccatctg cacgctcttc tacccctact gccaggccct acagactgag     2100

aaggaggcac ccatagcctc cctcggaaag ggctgcccgg ccacattacc ctccaaaagc     2160

cgtcagaaga cccgaccgct catccctgag atgtgcttca cctctggcgg tgagaacacg     2220

gagccgctgc ctgccaactc ctacatcggc gacgacggga ccagccccct gatcgcctgc     2280

ggcaagtgct gcctgcaggt ccatgccagt tgctatggca tccgtcccga gctggtcaat     2340

gaaggctgga cgtgttcccg gtgcgcggcc cacgcctgga ctgcggagtg ctgcctgtgc     2400

aacctgcgag gaggtgcgct gcagatgacc accgatagga ggtggatcca cgtgatctgt     2460

gccatcgcag tccccgaggc gcgcttcctg aacgtgattg agcgccaccc tgtggacatc     2520

agcgccatcc ccgagcagcg gtggaagctg aaatgcgtgt actgccggaa gcggatgaag     2580

aaggtgtcag gtgcctgtat ccagtgctcc tacgagcact gctccacgtc cttccacgtg     2640

acctgcgccc acgccgcagg cgtgctcatg gagccggacg actggcccta tgtggtctcc     2700

atcacctgcc tcaagcacaa gtcggggggt cacgctgtcc aactcctgag ggccgtgtcc     2760

ctaggccagg tggtcatcac caagaaccgc aacgggctgt actaccgctg tcgcgtcatc     2820

ggtgccgcct cgcagacctg ctacgaagtg aacttcgacg atggctccta cagcgacaac     2880

ctgtaccctg agagcatcac gagtagggac tgtgtccagc tgggaccccc ttccgagggg     2940

gagctggtgg agctccggtg gactgacggc aacctctaca aggccaagtt catctcctcc     3000

gtcaccagcc acatctacca ggtggagttt gaggacgggt cccagctgac ggtgaagcgt     3060

ggggacatct tcaccctgga ggaggagctg cccaagaggg tccgctctcg gctgtcactg     3120

agcacggggg caccgcagga gcccgccttc tcgggggagg aggccaaggc cgccaagcgc     3180

ccgcgtgtgg gcaccccgct tgccacggag gactccgggc ggagccagga ctacgtggcc     3240

ttcgtggaga gcctcctgca ggtgcagggc cggcccggag cccccttcta g              3291


<210>  33
<211>  1096
<212>  PRT
<213>  Homo sapiens

<400>  33

Met Gly Ser Glu Asp His Gly Ala Gln Asn Pro Ser Cys Lys Ile Met 
1               5                   10                  15      


Thr Phe Arg Pro Thr Met Glu Glu Phe Lys Asp Phe Asn Lys Tyr Val 
            20                  25                  30          


Ala Tyr Ile Glu Ser Gln Gly Ala His Arg Ala Gly Leu Ala Lys Ile 
        35                  40                  45              


Ile Pro Pro Lys Glu Trp Lys Pro Arg Gln Thr Tyr Asp Asp Ile Asp 
    50                  55                  60                  


Asp Val Val Ile Pro Ala Pro Ile Gln Gln Val Val Thr Gly Gln Ser 
65                  70                  75                  80  


Gly Leu Phe Thr Gln Tyr Asn Ile Gln Lys Lys Ala Met Thr Val Gly 
                85                  90                  95      


Glu Tyr Arg Arg Leu Ala Asn Ser Glu Lys Tyr Cys Thr Pro Arg His 
            100                 105                 110         


Gln Asp Phe Asp Asp Leu Glu Arg Lys Tyr Trp Lys Asn Leu Thr Phe 
        115                 120                 125             


Val Ser Pro Ile Tyr Gly Ala Asp Ile Ser Gly Ser Leu Tyr Asp Asp 
    130                 135                 140                 


Asp Val Ala Gln Trp Asn Ile Gly Ser Leu Arg Thr Ile Leu Asp Met 
145                 150                 155                 160 


Val Glu Arg Glu Cys Gly Thr Ile Ile Glu Gly Val Asn Thr Pro Tyr 
                165                 170                 175     


Leu Tyr Phe Gly Met Trp Lys Thr Thr Phe Ala Trp His Thr Glu Asp 
            180                 185                 190         


Met Asp Leu Tyr Ser Ile Asn Tyr Leu His Phe Gly Glu Pro Lys Ser 
        195                 200                 205             


Trp Tyr Ala Ile Pro Pro Glu His Gly Lys Arg Leu Glu Arg Leu Ala 
    210                 215                 220                 


Ile Gly Phe Phe Pro Gly Ser Ser Gln Gly Cys Asp Ala Phe Leu Arg 
225                 230                 235                 240 


His Lys Met Thr Leu Ile Ser Pro Ile Ile Leu Lys Lys Tyr Gly Ile 
                245                 250                 255     


Pro Phe Ser Arg Ile Thr Gln Glu Ala Gly Glu Phe Met Ile Thr Phe 
            260                 265                 270         


Pro Tyr Gly Tyr His Ala Gly Phe Asn His Gly Phe Asn Cys Ala Glu 
        275                 280                 285             


Ser Thr Asn Phe Ala Thr Leu Arg Trp Ile Asp Tyr Gly Lys Val Ala 
    290                 295                 300                 


Thr Gln Cys Thr Cys Arg Lys Asp Met Val Lys Ile Ser Met Asp Val 
305                 310                 315                 320 


Phe Val Arg Ile Leu Gln Pro Glu Arg Tyr Glu Leu Trp Lys Gln Gly 
                325                 330                 335     


Lys Asp Leu Thr Val Leu Asp His Thr Arg Pro Thr Ala Leu Thr Ser 
            340                 345                 350         


Pro Glu Leu Ser Ser Trp Ser Ala Ser Arg Ala Ser Leu Lys Ala Lys 
        355                 360                 365             


Leu Leu Arg Arg Ser His Arg Lys Arg Ser Gln Pro Lys Lys Pro Lys 
    370                 375                 380                 


Pro Glu Asp Pro Lys Phe Pro Gly Glu Gly Thr Ala Gly Ala Ala Leu 
385                 390                 395                 400 


Leu Glu Glu Ala Gly Gly Ser Val Lys Glu Glu Ala Gly Pro Glu Val 
                405                 410                 415     


Asp Pro Glu Glu Glu Glu Glu Glu Pro Gln Pro Leu Pro His Gly Arg 
            420                 425                 430         


Glu Ala Glu Gly Ala Glu Glu Asp Gly Arg Gly Lys Leu Arg Pro Thr 
        435                 440                 445             


Lys Ala Lys Ser Glu Arg Lys Lys Lys Ser Phe Gly Leu Leu Pro Pro 
    450                 455                 460                 


Gln Leu Pro Pro Pro Pro Ala His Phe Pro Ser Glu Glu Ala Leu Trp 
465                 470                 475                 480 


Leu Pro Ser Pro Leu Glu Pro Pro Val Leu Gly Pro Gly Pro Ala Ala 
                485                 490                 495     


Met Glu Glu Ser Pro Leu Pro Ala Pro Leu Asn Val Val Pro Pro Glu 
            500                 505                 510         


Val Pro Ser Glu Glu Leu Glu Ala Lys Pro Arg Pro Ile Ile Pro Met 
        515                 520                 525             


Leu Tyr Val Val Pro Arg Pro Gly Lys Ala Ala Phe Asn Gln Glu His 
    530                 535                 540                 


Val Ser Cys Gln Gln Ala Phe Glu His Phe Ala Gln Lys Gly Pro Thr 
545                 550                 555                 560 


Trp Lys Glu Pro Val Ser Pro Met Glu Leu Thr Gly Pro Glu Asp Gly 
                565                 570                 575     


Ala Ala Ser Ser Gly Ala Gly Arg Met Glu Thr Lys Ala Arg Ala Gly 
            580                 585                 590         


Glu Gly Gln Ala Pro Ser Thr Phe Ser Lys Leu Lys Met Glu Ile Lys 
        595                 600                 605             


Lys Ser Arg Arg His Pro Leu Gly Arg Pro Pro Thr Arg Ser Pro Leu 
    610                 615                 620                 


Ser Val Val Lys Gln Glu Ala Ser Ser Asp Glu Glu Ala Ser Pro Phe 
625                 630                 635                 640 


Ser Gly Glu Glu Asp Val Ser Asp Pro Asp Ala Leu Arg Pro Leu Leu 
                645                 650                 655     


Ser Leu Gln Trp Lys Asn Arg Ala Ala Ser Phe Gln Ala Glu Arg Lys 
            660                 665                 670         


Phe Asn Ala Ala Ala Ala Arg Thr Glu Pro Tyr Cys Ala Ile Cys Thr 
        675                 680                 685             


Leu Phe Tyr Pro Tyr Cys Gln Ala Leu Gln Thr Glu Lys Glu Ala Pro 
    690                 695                 700                 


Ile Ala Ser Leu Gly Lys Gly Cys Pro Ala Thr Leu Pro Ser Lys Ser 
705                 710                 715                 720 


Arg Gln Lys Thr Arg Pro Leu Ile Pro Glu Met Cys Phe Thr Ser Gly 
                725                 730                 735     


Gly Glu Asn Thr Glu Pro Leu Pro Ala Asn Ser Tyr Ile Gly Asp Asp 
            740                 745                 750         


Gly Thr Ser Pro Leu Ile Ala Cys Gly Lys Cys Cys Leu Gln Val His 
        755                 760                 765             


Ala Ser Cys Tyr Gly Ile Arg Pro Glu Leu Val Asn Glu Gly Trp Thr 
    770                 775                 780                 


Cys Ser Arg Cys Ala Ala His Ala Trp Thr Ala Glu Cys Cys Leu Cys 
785                 790                 795                 800 


Asn Leu Arg Gly Gly Ala Leu Gln Met Thr Thr Asp Arg Arg Trp Ile 
                805                 810                 815     


His Val Ile Cys Ala Ile Ala Val Pro Glu Ala Arg Phe Leu Asn Val 
            820                 825                 830         


Ile Glu Arg His Pro Val Asp Ile Ser Ala Ile Pro Glu Gln Arg Trp 
        835                 840                 845             


Lys Leu Lys Cys Val Tyr Cys Arg Lys Arg Met Lys Lys Val Ser Gly 
    850                 855                 860                 


Ala Cys Ile Gln Cys Ser Tyr Glu His Cys Ser Thr Ser Phe His Val 
865                 870                 875                 880 


Thr Cys Ala His Ala Ala Gly Val Leu Met Glu Pro Asp Asp Trp Pro 
                885                 890                 895     


Tyr Val Val Ser Ile Thr Cys Leu Lys His Lys Ser Gly Gly His Ala 
            900                 905                 910         


Val Gln Leu Leu Arg Ala Val Ser Leu Gly Gln Val Val Ile Thr Lys 
        915                 920                 925             


Asn Arg Asn Gly Leu Tyr Tyr Arg Cys Arg Val Ile Gly Ala Ala Ser 
    930                 935                 940                 


Gln Thr Cys Tyr Glu Val Asn Phe Asp Asp Gly Ser Tyr Ser Asp Asn 
945                 950                 955                 960 


Leu Tyr Pro Glu Ser Ile Thr Ser Arg Asp Cys Val Gln Leu Gly Pro 
                965                 970                 975     


Pro Ser Glu Gly Glu Leu Val Glu Leu Arg Trp Thr Asp Gly Asn Leu 
            980                 985                 990         


Tyr Lys Ala Lys Phe Ile Ser Ser  Val Thr Ser His Ile  Tyr Gln Val 
        995                 1000                 1005             


Glu Phe  Glu Asp Gly Ser Gln  Leu Thr Val Lys Arg  Gly Asp Ile 
    1010                 1015                 1020             


Phe Thr  Leu Glu Glu Glu Leu  Pro Lys Arg Val Arg  Ser Arg Leu 
    1025                 1030                 1035             


Ser Leu  Ser Thr Gly Ala Pro  Gln Glu Pro Ala Phe  Ser Gly Glu 
    1040                 1045                 1050             


Glu Ala  Lys Ala Ala Lys Arg  Pro Arg Val Gly Thr  Pro Leu Ala 
    1055                 1060                 1065             


Thr Glu  Asp Ser Gly Arg Ser  Gln Asp Tyr Val Ala  Phe Val Glu 
    1070                 1075                 1080             


Ser Leu  Leu Gln Val Gln Gly  Arg Pro Gly Ala Pro  Phe 
    1085                 1090                 1095     


<210>  34
<211>  3171
<212>  DNA
<213>  Homo sapiens

<400>  34
atggaggtgg ccgaggtgga aagtcctctg aaccccagct gtaagataat gaccttcaga       60

ccctccatgg aggagttccg ggagttcaac aaataccttg catacatgga gtctaaagga      120

gcccatcgtg cgggtcttgc aaaggtgatt cctcctaagg agtggaagcc aagacagtgc      180

tatgatgaca ttgataattt gctcattcca gcaccaattc agcagatggt cacagggcag      240

tcaggactgt tcactcagta caacatccag aaaaaagcga tgactgtgaa ggagttcagg      300

cagctggcca acagtggcaa atattgtact ccaagatact tggattacga agatttggag      360

cgcaagtact ggaagaactt aacttttgtg gcacctatct atggtgcaga tattaatggg      420

agcatatatg atgagggtgt ggatgaatgg aacatagctc gcctcaatac agtcttggat      480

gtggttgaag aagagtgtgg catttctatt gagggtgtaa ataccccata tctctatttt      540

ggcatgtgga agaccacgtt tgcatggcac accgaagaca tggacctcta tagcattaat      600

tatctccact ttggagagcc caagtcttgg tatgctatac ctccggagca tggaaaacga      660

cttgaaagac tagctcaagg ttttttccca agcagctccc aagggtgtga tgcatttctt      720

cgccacaaga tgacattgat ttctccatca gtattgaaga aatatggtat tccctttgac      780

aagataaccc aggaggctgg agaattcatg atcactttcc catatggcta ccatgctggt      840

tttaatcatg gtttcaactg tgcagaatct acaaattttg ctactgtcag atggattgac      900

tatggaaaag ttgccaaatt gtgcacttgc aggaaagaca tggtgaagat ttcaatggat      960

atctttgtga ggaaatttca gccagacaga tatcagcttt ggaaacaagg aaaggatata     1020

tacaccattg atcacacgaa gcctactcca gcatccaccc ctgaagtaaa agcatggctg     1080

cagaggagga ggaaagtaag aaaagcatcc cgaagcttcc agtgtgctag gtctacctct     1140

aaaaggccta aggctgatga ggaagaggaa gtgtcagatg aagtcgatgg ggcagaggtc     1200

cctaaccccg actcagtcac agatgacctc aaggtcagtg aaaagtcaga agcagcagtg     1260

aagctgagga acacagaagc atcttcagaa gaagagtcat ctgctagcag gatgcaggtg     1320

gagcagaatt tatcagatca tatcaaactc tcaggaaaca gctgcttaag tacatctgta     1380

acagaagaca taaaaactga ggatgacaaa gcttatgcat atagaagtgt accttctata     1440

tccagtgagg ctgatgattc cattccattg tctagtggct atgagaagcc cgagaaatca     1500

gacccatccg agctttcatg gccaaagtca cctgagtcat gctcatcagt ggcagagagt     1560

aatggtgtgt taacagaggg agaagagagt gatgtggaga gccatgggaa tggccttgaa     1620

cctggggaaa tcccagcggt ccccagtgga gagagaaata gcttcaaagt ccccagtata     1680

gcagagggag agaacaaaac ctctaagagt tggcgccatc cacttagcag gcctccagca     1740

agatctccga tgactcttgt gaagcagcag gcgccaagtg atgaagaatt gcctgaggtt     1800

ctgtccattg aggaggaagt ggaagaaaca gagtcttggg cgaaacctct catccacctt     1860

tggcagacga agtcccctaa cttcgcagct gagcaagagt ataatgcaac agtggccagg     1920

atgaagccac actgtgccat ctgcactctg ctcatgccgt accacaagcc agatagcagc     1980

aatgaagaaa atgatgctag atgggagaca aaattagatg aagtcgttac atcggaggga     2040

aagactaagc ccctcatacc agagatgtgt tttatttata gtgaagaaaa tatagaatat     2100

tctccaccca atgccttcct tgaagaggat ggaacaagtc tccttatttc ctgtgcaaag     2160

tgctgcgtac gggttcatgc aagttgttat ggtattcctt ctcatgagat ctgtgatgga     2220

tggctgtgtg cccggtgcaa aagaaatgcg tggacagcag aatgctgtct ctgcaatttg     2280

agaggaggtg ctcttaagca aacgaagaac aataagtggg cccatgtcat gtgcgccgtt     2340

gcggtcccag aagttcgatt cactaatgtc ccagaaagga cacaaataga tgtaggcaga     2400

atacctttac agaggttaaa attgaaatgc atcttctgca gacaccgggt taagagggtc     2460

tctggagcct gcatccagtg ttcctacggt cgctgcccgg cctccttcca tgtcacttgt     2520

gcccatgctg ctggggtact gatggagcct gatgactggc cttatgtggt gaacattaca     2580

tgctttcgac ataaggtcaa ccccaacgtg aagtccaagg cttgcgagaa ggtcatttcc     2640

gtgggtcaaa cggtcatcac gaagcatcgg aacacccggt attacagttg cagagtgatg     2700

gctgtgacat cgcagacctt ctatgaggtc atgtttgatg atggctcctt tagcagagac     2760

acatttcctg aggatatcgt gagccgagac tgtctgaagc tgggcccacc tgctgaggga     2820

gaagtcgtcc aagtcaagtg gcccgatggc aaactctatg gagcaaaata ttttggatca     2880

aatattgccc acatgtacca ggttgagttt gaagatggat cccagatagc aatgaagaga     2940

gaggacatct acactttaga tgaagagtta cccaagagag tgaaagctcg attttccaca     3000

gcctctgaca tgcgatttga agacacgttt tatggagcag acattatcca aggggagaga     3060

aagagacaaa gagtgctgag ctccaggttt aagaatgaat atgtggccga ccctgtatac     3120

cgcacttttt tgaagagctc tttccagaag aagtgccaga agagacagta g              3171


<210>  35
<211>  1056
<212>  PRT
<213>  Homo sapiens

<400>  35

Met Glu Val Ala Glu Val Glu Ser Pro Leu Asn Pro Ser Cys Lys Ile 
1               5                   10                  15      


Met Thr Phe Arg Pro Ser Met Glu Glu Phe Arg Glu Phe Asn Lys Tyr 
            20                  25                  30          


Leu Ala Tyr Met Glu Ser Lys Gly Ala His Arg Ala Gly Leu Ala Lys 
        35                  40                  45              


Val Ile Pro Pro Lys Glu Trp Lys Pro Arg Gln Cys Tyr Asp Asp Ile 
    50                  55                  60                  


Asp Asn Leu Leu Ile Pro Ala Pro Ile Gln Gln Met Val Thr Gly Gln 
65                  70                  75                  80  


Ser Gly Leu Phe Thr Gln Tyr Asn Ile Gln Lys Lys Ala Met Thr Val 
                85                  90                  95      


Lys Glu Phe Arg Gln Leu Ala Asn Ser Gly Lys Tyr Cys Thr Pro Arg 
            100                 105                 110         


Tyr Leu Asp Tyr Glu Asp Leu Glu Arg Lys Tyr Trp Lys Asn Leu Thr 
        115                 120                 125             


Phe Val Ala Pro Ile Tyr Gly Ala Asp Ile Asn Gly Ser Ile Tyr Asp 
    130                 135                 140                 


Glu Gly Val Asp Glu Trp Asn Ile Ala Arg Leu Asn Thr Val Leu Asp 
145                 150                 155                 160 


Val Val Glu Glu Glu Cys Gly Ile Ser Ile Glu Gly Val Asn Thr Pro 
                165                 170                 175     


Tyr Leu Tyr Phe Gly Met Trp Lys Thr Thr Phe Ala Trp His Thr Glu 
            180                 185                 190         


Asp Met Asp Leu Tyr Ser Ile Asn Tyr Leu His Phe Gly Glu Pro Lys 
        195                 200                 205             


Ser Trp Tyr Ala Ile Pro Pro Glu His Gly Lys Arg Leu Glu Arg Leu 
    210                 215                 220                 


Ala Gln Gly Phe Phe Pro Ser Ser Ser Gln Gly Cys Asp Ala Phe Leu 
225                 230                 235                 240 


Arg His Lys Met Thr Leu Ile Ser Pro Ser Val Leu Lys Lys Tyr Gly 
                245                 250                 255     


Ile Pro Phe Asp Lys Ile Thr Gln Glu Ala Gly Glu Phe Met Ile Thr 
            260                 265                 270         


Phe Pro Tyr Gly Tyr His Ala Gly Phe Asn His Gly Phe Asn Cys Ala 
        275                 280                 285             


Glu Ser Thr Asn Phe Ala Thr Val Arg Trp Ile Asp Tyr Gly Lys Val 
    290                 295                 300                 


Ala Lys Leu Cys Thr Cys Arg Lys Asp Met Val Lys Ile Ser Met Asp 
305                 310                 315                 320 


Ile Phe Val Arg Lys Phe Gln Pro Asp Arg Tyr Gln Leu Trp Lys Gln 
                325                 330                 335     


Gly Lys Asp Ile Tyr Thr Ile Asp His Thr Lys Pro Thr Pro Ala Ser 
            340                 345                 350         


Thr Pro Glu Val Lys Ala Trp Leu Gln Arg Arg Arg Lys Val Arg Lys 
        355                 360                 365             


Ala Ser Arg Ser Phe Gln Cys Ala Arg Ser Thr Ser Lys Arg Pro Lys 
    370                 375                 380                 


Ala Asp Glu Glu Glu Glu Val Ser Asp Glu Val Asp Gly Ala Glu Val 
385                 390                 395                 400 


Pro Asn Pro Asp Ser Val Thr Asp Asp Leu Lys Val Ser Glu Lys Ser 
                405                 410                 415     


Glu Ala Ala Val Lys Leu Arg Asn Thr Glu Ala Ser Ser Glu Glu Glu 
            420                 425                 430         


Ser Ser Ala Ser Arg Met Gln Val Glu Gln Asn Leu Ser Asp His Ile 
        435                 440                 445             


Lys Leu Ser Gly Asn Ser Cys Leu Ser Thr Ser Val Thr Glu Asp Ile 
    450                 455                 460                 


Lys Thr Glu Asp Asp Lys Ala Tyr Ala Tyr Arg Ser Val Pro Ser Ile 
465                 470                 475                 480 


Ser Ser Glu Ala Asp Asp Ser Ile Pro Leu Ser Ser Gly Tyr Glu Lys 
                485                 490                 495     


Pro Glu Lys Ser Asp Pro Ser Glu Leu Ser Trp Pro Lys Ser Pro Glu 
            500                 505                 510         


Ser Cys Ser Ser Val Ala Glu Ser Asn Gly Val Leu Thr Glu Gly Glu 
        515                 520                 525             


Glu Ser Asp Val Glu Ser His Gly Asn Gly Leu Glu Pro Gly Glu Ile 
    530                 535                 540                 


Pro Ala Val Pro Ser Gly Glu Arg Asn Ser Phe Lys Val Pro Ser Ile 
545                 550                 555                 560 


Ala Glu Gly Glu Asn Lys Thr Ser Lys Ser Trp Arg His Pro Leu Ser 
                565                 570                 575     


Arg Pro Pro Ala Arg Ser Pro Met Thr Leu Val Lys Gln Gln Ala Pro 
            580                 585                 590         


Ser Asp Glu Glu Leu Pro Glu Val Leu Ser Ile Glu Glu Glu Val Glu 
        595                 600                 605             


Glu Thr Glu Ser Trp Ala Lys Pro Leu Ile His Leu Trp Gln Thr Lys 
    610                 615                 620                 


Ser Pro Asn Phe Ala Ala Glu Gln Glu Tyr Asn Ala Thr Val Ala Arg 
625                 630                 635                 640 


Met Lys Pro His Cys Ala Ile Cys Thr Leu Leu Met Pro Tyr His Lys 
                645                 650                 655     


Pro Asp Ser Ser Asn Glu Glu Asn Asp Ala Arg Trp Glu Thr Lys Leu 
            660                 665                 670         


Asp Glu Val Val Thr Ser Glu Gly Lys Thr Lys Pro Leu Ile Pro Glu 
        675                 680                 685             


Met Cys Phe Ile Tyr Ser Glu Glu Asn Ile Glu Tyr Ser Pro Pro Asn 
    690                 695                 700                 


Ala Phe Leu Glu Glu Asp Gly Thr Ser Leu Leu Ile Ser Cys Ala Lys 
705                 710                 715                 720 


Cys Cys Val Arg Val His Ala Ser Cys Tyr Gly Ile Pro Ser His Glu 
                725                 730                 735     


Ile Cys Asp Gly Trp Leu Cys Ala Arg Cys Lys Arg Asn Ala Trp Thr 
            740                 745                 750         


Ala Glu Cys Cys Leu Cys Asn Leu Arg Gly Gly Ala Leu Lys Gln Thr 
        755                 760                 765             


Lys Asn Asn Lys Trp Ala His Val Met Cys Ala Val Ala Val Pro Glu 
    770                 775                 780                 


Val Arg Phe Thr Asn Val Pro Glu Arg Thr Gln Ile Asp Val Gly Arg 
785                 790                 795                 800 


Ile Pro Leu Gln Arg Leu Lys Leu Lys Cys Ile Phe Cys Arg His Arg 
                805                 810                 815     


Val Lys Arg Val Ser Gly Ala Cys Ile Gln Cys Ser Tyr Gly Arg Cys 
            820                 825                 830         


Pro Ala Ser Phe His Val Thr Cys Ala His Ala Ala Gly Val Leu Met 
        835                 840                 845             


Glu Pro Asp Asp Trp Pro Tyr Val Val Asn Ile Thr Cys Phe Arg His 
    850                 855                 860                 


Lys Val Asn Pro Asn Val Lys Ser Lys Ala Cys Glu Lys Val Ile Ser 
865                 870                 875                 880 


Val Gly Gln Thr Val Ile Thr Lys His Arg Asn Thr Arg Tyr Tyr Ser 
                885                 890                 895     


Cys Arg Val Met Ala Val Thr Ser Gln Thr Phe Tyr Glu Val Met Phe 
            900                 905                 910         


Asp Asp Gly Ser Phe Ser Arg Asp Thr Phe Pro Glu Asp Ile Val Ser 
        915                 920                 925             


Arg Asp Cys Leu Lys Leu Gly Pro Pro Ala Glu Gly Glu Val Val Gln 
    930                 935                 940                 


Val Lys Trp Pro Asp Gly Lys Leu Tyr Gly Ala Lys Tyr Phe Gly Ser 
945                 950                 955                 960 


Asn Ile Ala His Met Tyr Gln Val Glu Phe Glu Asp Gly Ser Gln Ile 
                965                 970                 975     


Ala Met Lys Arg Glu Asp Ile Tyr Thr Leu Asp Glu Glu Leu Pro Lys 
            980                 985                 990         


Arg Val Lys Ala Arg Phe Ser Thr  Ala Ser Asp Met Arg  Phe Glu Asp 
        995                 1000                 1005             


Thr Phe  Tyr Gly Ala Asp Ile  Ile Gln Gly Glu Arg  Lys Arg Gln 
    1010                 1015                 1020             


Arg Val  Leu Ser Ser Arg Phe  Lys Asn Glu Tyr Val  Ala Asp Pro 
    1025                 1030                 1035             


Val Tyr  Arg Thr Phe Leu Lys  Ser Ser Phe Gln Lys  Lys Cys Gln 
    1040                 1045                 1050             


Lys Arg  Gln 
    1055     


<210>  36
<211>  411
<212>  DNA
<213>  Homo sapiens

<400>  36
atggctcgca ctaagcaaac tgctcggaag tctactggtg gcaaggcgcc acgcaaacag       60

ttggccacta aggcagcccg caaaagcgct ccggccaccg gcggcgtgaa aaagccccac      120

cgctaccggc cgggcaccgt ggctctgcgc gagatccgcc gttatcagaa gtccactgaa      180

ctgcttattc gtaaactacc tttccagcgc ctggtgcgcg agattgcgca ggactttaaa      240

acagacctgc gtttccagag ctccgctgtg atggctctgc aggaggcgtg cgaggcctac      300

ttggtagggc tatttgagga cactaacctg tgcgccatcc acgccaagcg cgtcactatc      360

atgcccaagg acatccagct cgcccgccgc atccgcggag agagggcgtg a               411


<210>  37
<211>  136
<212>  PRT
<213>  Homo sapiens

<400>  37

Met Ala Arg Thr Lys Gln Thr Ala Arg Lys Ser Thr Gly Gly Lys Ala 
1               5                   10                  15      


Pro Arg Lys Gln Leu Ala Thr Lys Ala Ala Arg Lys Ser Ala Pro Ala 
            20                  25                  30          


Thr Gly Gly Val Lys Lys Pro His Arg Tyr Arg Pro Gly Thr Val Ala 
        35                  40                  45              


Leu Arg Glu Ile Arg Arg Tyr Gln Lys Ser Thr Glu Leu Leu Ile Arg 
    50                  55                  60                  


Lys Leu Pro Phe Gln Arg Leu Val Arg Glu Ile Ala Gln Asp Phe Lys 
65                  70                  75                  80  


Thr Asp Leu Arg Phe Gln Ser Ser Ala Val Met Ala Leu Gln Glu Ala 
                85                  90                  95      


Cys Glu Ala Tyr Leu Val Gly Leu Phe Glu Asp Thr Asn Leu Cys Ala 
            100                 105                 110         


Ile His Ala Lys Arg Val Thr Ile Met Pro Lys Asp Ile Gln Leu Ala 
        115                 120                 125             


Arg Arg Ile Arg Gly Glu Arg Ala 
    130                 135     


<210>  38
<211>  411
<212>  DNA
<213>  Homo sapiens

<400>  38
atggctcgta ctaaacagac agctcggaaa tccaccggcg gtaaagcgcc acgcaagcag       60

ctggctacca aggctgctcg caagagcgcg ccggctaccg gcggcgtgaa aaagcctcac      120

cgttaccgcc cgggcactgt ggctctgcgc gagatccgcc gctaccaaaa gtcgaccgag      180

ttgctgattc ggaagctgcc gttccagcgc ctggtgcgag aaatcgccca agacttcaag      240

accgatcttc gcttccagag ctctgcggtg atggcgctgc aggaggcttg tgaggcctac      300

ttggtagggc tctttgagga cacaaacctt tgcgccatcc atgctaagcg agtgactatt      360

atgcccaaag acatccagct cgctcgccgc attcgcggag aaagagcgta a               411


<210>  39
<211>  136
<212>  PRT
<213>  Homo sapiens

<400>  39

Met Ala Arg Thr Lys Gln Thr Ala Arg Lys Ser Thr Gly Gly Lys Ala 
1               5                   10                  15      


Pro Arg Lys Gln Leu Ala Thr Lys Ala Ala Arg Lys Ser Ala Pro Ala 
            20                  25                  30          


Thr Gly Gly Val Lys Lys Pro His Arg Tyr Arg Pro Gly Thr Val Ala 
        35                  40                  45              


Leu Arg Glu Ile Arg Arg Tyr Gln Lys Ser Thr Glu Leu Leu Ile Arg 
    50                  55                  60                  


Lys Leu Pro Phe Gln Arg Leu Val Arg Glu Ile Ala Gln Asp Phe Lys 
65                  70                  75                  80  


Thr Asp Leu Arg Phe Gln Ser Ser Ala Val Met Ala Leu Gln Glu Ala 
                85                  90                  95      


Cys Glu Ala Tyr Leu Val Gly Leu Phe Glu Asp Thr Asn Leu Cys Ala 
            100                 105                 110         


Ile His Ala Lys Arg Val Thr Ile Met Pro Lys Asp Ile Gln Leu Ala 
        115                 120                 125             


Arg Arg Ile Arg Gly Glu Arg Ala 
    130                 135     


<210>  40
<211>  411
<212>  DNA
<213>  Homo sapiens

<400>  40
atggctcgta cgaagcaaac agctcgcaag tctaccggcg gcaaagctcc gcgcaagcag       60

cttgctacta aagcagcccg taagagcgct ccggccaccg gtggcgtgaa gaaacctcat      120

cgctaccgcc cgggcaccgt ggccttgcgc gaaatccgtc gctaccagaa gtccaccgag      180

ctgctgatcc ggaagctgcc gttccagcgc ctggtgcgag aaatcgccca ggacttcaaa      240

accgacctgc gtttccagag ctctgcggtg atggcgctgc aggaggcttg tgaggcctac      300

ctggtgggac tcttcgaaga caccaatctg tgcgctattc acgctaaacg cgtcaccatc      360

atgcccaaag atatccagct ggcacgtcgc atccgtgggg aaagggcata a               411


<210>  41
<211>  136
<212>  PRT
<213>  Homo sapiens

<400>  41

Met Ala Arg Thr Lys Gln Thr Ala Arg Lys Ser Thr Gly Gly Lys Ala 
1               5                   10                  15      


Pro Arg Lys Gln Leu Ala Thr Lys Ala Ala Arg Lys Ser Ala Pro Ala 
            20                  25                  30          


Thr Gly Gly Val Lys Lys Pro His Arg Tyr Arg Pro Gly Thr Val Ala 
        35                  40                  45              


Leu Arg Glu Ile Arg Arg Tyr Gln Lys Ser Thr Glu Leu Leu Ile Arg 
    50                  55                  60                  


Lys Leu Pro Phe Gln Arg Leu Val Arg Glu Ile Ala Gln Asp Phe Lys 
65                  70                  75                  80  


Thr Asp Leu Arg Phe Gln Ser Ser Ala Val Met Ala Leu Gln Glu Ala 
                85                  90                  95      


Cys Glu Ala Tyr Leu Val Gly Leu Phe Glu Asp Thr Asn Leu Cys Ala 
            100                 105                 110         


Ile His Ala Lys Arg Val Thr Ile Met Pro Lys Asp Ile Gln Leu Ala 
        115                 120                 125             


Arg Arg Ile Arg Gly Glu Arg Ala 
    130                 135     


<210>  42
<211>  411
<212>  DNA
<213>  Homo sapiens

<400>  42
atggctcgta ccaagcagac tgctcgcaag tccacgggtg ggaaagcgcc acgcaagcag       60

ctggccacca aggctgctcg aaagagcgct ccagccaccg gcggcgtgaa gaagccccac      120

cgttaccggc ccggcacggt ggctctgcgc gagatccgcc gctaccagaa gtcgaccgag      180

ctgctgattc gcaaactgcc attccagcgt ctagtccgtg agatcgcgca ggacttcaag      240

actgatctgc gttttcagag ctcggcggtg atggcgctgc aggaggcctg cgaggcctac      300

ctggtggggc tgtttgagga caccaaccta tgcgccattc acgccaagcg agtgactatc      360

atgcccaagg acatccagct tgctcgccgc attcgtgggg agagggcgta a               411


<210>  43
<211>  136
<212>  PRT
<213>  Homo sapiens

<400>  43

Met Ala Arg Thr Lys Gln Thr Ala Arg Lys Ser Thr Gly Gly Lys Ala 
1               5                   10                  15      


Pro Arg Lys Gln Leu Ala Thr Lys Ala Ala Arg Lys Ser Ala Pro Ala 
            20                  25                  30          


Thr Gly Gly Val Lys Lys Pro His Arg Tyr Arg Pro Gly Thr Val Ala 
        35                  40                  45              


Leu Arg Glu Ile Arg Arg Tyr Gln Lys Ser Thr Glu Leu Leu Ile Arg 
    50                  55                  60                  


Lys Leu Pro Phe Gln Arg Leu Val Arg Glu Ile Ala Gln Asp Phe Lys 
65                  70                  75                  80  


Thr Asp Leu Arg Phe Gln Ser Ser Ala Val Met Ala Leu Gln Glu Ala 
                85                  90                  95      


Cys Glu Ala Tyr Leu Val Gly Leu Phe Glu Asp Thr Asn Leu Cys Ala 
            100                 105                 110         


Ile His Ala Lys Arg Val Thr Ile Met Pro Lys Asp Ile Gln Leu Ala 
        115                 120                 125             


Arg Arg Ile Arg Gly Glu Arg Ala 
    130                 135     


<210>  44
<211>  411
<212>  DNA
<213>  Homo sapiens

<400>  44
atggcgcgta ctaagcagac ggctcgtaaa tccacaggcg gtaaagcacc gcgcaaacag       60

ctggccacta aggcagctcg caagagcgct ccggccacgg gcggcgtgaa gaagccccat      120

cgctaccgcc ctggcaccgt ggctctgcgc gagatccgtc gctaccagaa gtctaccgag      180

cttctaatcc ggaagctgcc gtttcagcgc ctggtgcgag aaatagctca ggacttcaag      240

accgacctgc gcttccagag ttccgcggtg atggcgctgc aggaggcctg cgaggcctac      300

ttggtggggc ttttcgagga caccaacctg tgcgctattc atgccaaacg cgtgaccatc      360

atgcctaaag acatccagct tgcccgccgc attcgtgggg agagggcgtg a               411


<210>  45
<211>  136
<212>  PRT
<213>  Homo sapiens

<400>  45

Met Ala Arg Thr Lys Gln Thr Ala Arg Lys Ser Thr Gly Gly Lys Ala 
1               5                   10                  15      


Pro Arg Lys Gln Leu Ala Thr Lys Ala Ala Arg Lys Ser Ala Pro Ala 
            20                  25                  30          


Thr Gly Gly Val Lys Lys Pro His Arg Tyr Arg Pro Gly Thr Val Ala 
        35                  40                  45              


Leu Arg Glu Ile Arg Arg Tyr Gln Lys Ser Thr Glu Leu Leu Ile Arg 
    50                  55                  60                  


Lys Leu Pro Phe Gln Arg Leu Val Arg Glu Ile Ala Gln Asp Phe Lys 
65                  70                  75                  80  


Thr Asp Leu Arg Phe Gln Ser Ser Ala Val Met Ala Leu Gln Glu Ala 
                85                  90                  95      


Cys Glu Ala Tyr Leu Val Gly Leu Phe Glu Asp Thr Asn Leu Cys Ala 
            100                 105                 110         


Ile His Ala Lys Arg Val Thr Ile Met Pro Lys Asp Ile Gln Leu Ala 
        115                 120                 125             


Arg Arg Ile Arg Gly Glu Arg Ala 
    130                 135     


<210>  46
<211>  411
<212>  DNA
<213>  Homo sapiens

<400>  46
atggcacgca cgaagcaaac agctcgtaag tccactggcg gcaaagcccc gcgcaagcag       60

ctggccacta aggcggctcg caaaagcgcg ccagccaccg gtggcgtgaa gaagccccac      120

cgctacaggc ctggtactgt cgccctccgt gaaatccgcc gctatcagaa atcgactgag      180

ctactgattc gcaagctacc attccagcgt ctggtacgtg agatcgcgca ggacttcaag      240

accgacctgc gcttccagag ctcggctgtg atggcgctgc aggaggcctg cgaggcttac      300

ctggtggggc tctttgagga caccaacctg tgtgctatcc acgccaagcg agtgactatc      360

atgcccaagg acatccagct cgctcgccgc attcgcggag agagggcata a               411


<210>  47
<211>  136
<212>  PRT
<213>  Homo sapiens

<400>  47

Met Ala Arg Thr Lys Gln Thr Ala Arg Lys Ser Thr Gly Gly Lys Ala 
1               5                   10                  15      


Pro Arg Lys Gln Leu Ala Thr Lys Ala Ala Arg Lys Ser Ala Pro Ala 
            20                  25                  30          


Thr Gly Gly Val Lys Lys Pro His Arg Tyr Arg Pro Gly Thr Val Ala 
        35                  40                  45              


Leu Arg Glu Ile Arg Arg Tyr Gln Lys Ser Thr Glu Leu Leu Ile Arg 
    50                  55                  60                  


Lys Leu Pro Phe Gln Arg Leu Val Arg Glu Ile Ala Gln Asp Phe Lys 
65                  70                  75                  80  


Thr Asp Leu Arg Phe Gln Ser Ser Ala Val Met Ala Leu Gln Glu Ala 
                85                  90                  95      


Cys Glu Ala Tyr Leu Val Gly Leu Phe Glu Asp Thr Asn Leu Cys Ala 
            100                 105                 110         


Ile His Ala Lys Arg Val Thr Ile Met Pro Lys Asp Ile Gln Leu Ala 
        115                 120                 125             


Arg Arg Ile Arg Gly Glu Arg Ala 
    130                 135     


<210>  48
<211>  411
<212>  DNA
<213>  Homo sapiens

<400>  48
atggcccgca ccaagcagac tgcacgcaag tccaccggtg gcaaagcgcc gcgcaagcag       60

ctggccacta aggcggctcg gaaaagcgcg ccggccaccg gcggcgtgaa gaaacctcat      120

cgctaccgtc ccggcaccgt ggctctgcgc gagattcgcc gctatcagaa gtcgactgag      180

ctgctgatcc gcaagttgcc tttccaacgc ctggtgcgag aaatcgctca ggacttcaag      240

acagatctgc gctttcagag ttccgcggtg atggccctgc aggaggcctg cgaggcctac      300

ttggtggggc tctttgagga taccaacctg tgtgccatcc atgctaagcg agtgactatc      360

atgcccaagg acattcagct cgctcgccgc attcgtgggg agagagcgta g               411


<210>  49
<211>  136
<212>  PRT
<213>  Homo sapiens

<400>  49

Met Ala Arg Thr Lys Gln Thr Ala Arg Lys Ser Thr Gly Gly Lys Ala 
1               5                   10                  15      


Pro Arg Lys Gln Leu Ala Thr Lys Ala Ala Arg Lys Ser Ala Pro Ala 
            20                  25                  30          


Thr Gly Gly Val Lys Lys Pro His Arg Tyr Arg Pro Gly Thr Val Ala 
        35                  40                  45              


Leu Arg Glu Ile Arg Arg Tyr Gln Lys Ser Thr Glu Leu Leu Ile Arg 
    50                  55                  60                  


Lys Leu Pro Phe Gln Arg Leu Val Arg Glu Ile Ala Gln Asp Phe Lys 
65                  70                  75                  80  


Thr Asp Leu Arg Phe Gln Ser Ser Ala Val Met Ala Leu Gln Glu Ala 
                85                  90                  95      


Cys Glu Ala Tyr Leu Val Gly Leu Phe Glu Asp Thr Asn Leu Cys Ala 
            100                 105                 110         


Ile His Ala Lys Arg Val Thr Ile Met Pro Lys Asp Ile Gln Leu Ala 
        115                 120                 125             


Arg Arg Ile Arg Gly Glu Arg Ala 
    130                 135     


<210>  50
<211>  411
<212>  PRT
<213>  Homo sapiens

<400>  50

Ala Thr Gly Gly Cys Gly Cys Gly Thr Ala Cys Gly Ala Ala Gly Cys 
1               5                   10                  15      


Ala Gly Ala Cys Thr Gly Cys Thr Cys Gly Cys Ala Ala Gly Thr Cys 
            20                  25                  30          


Cys Ala Cys Cys Gly Gly Cys Gly Gly Cys Ala Ala Gly Gly Cys Thr 
        35                  40                  45              


Cys Cys Gly Cys Gly Cys Ala Ala Gly Cys Ala Gly Cys Thr Gly Gly 
    50                  55                  60                  


Cys Cys Ala Cys Cys Ala Ala Gly Gly Cys Gly Gly Cys Thr Cys Gly 
65                  70                  75                  80  


Gly Ala Ala Gly Ala Gly Cys Gly Cys Thr Cys Cys Gly Gly Cys Cys 
                85                  90                  95      


Ala Cys Cys Gly Gly Cys Gly Gly Thr Gly Thr Cys Ala Ala Gly Ala 
            100                 105                 110         


Ala Gly Cys Cys Cys Cys Ala Thr Cys Gly Cys Thr Ala Thr Cys Gly 
        115                 120                 125             


Gly Cys Cys Thr Gly Gly Thr Ala Cys Ala Gly Thr Gly Gly Cys Thr 
    130                 135                 140                 


Cys Thr Cys Cys Gly Cys Gly Ala Gly Ala Thr Thr Cys Gly Cys Cys 
145                 150                 155                 160 


Gly Cys Thr Ala Cys Cys Ala Gly Ala Ala Gly Thr Cys Cys Ala Cys 
                165                 170                 175     


Cys Gly Ala Gly Cys Thr Gly Cys Thr Gly Ala Thr Cys Ala Gly Ala 
            180                 185                 190         


Ala Ala Gly Cys Thr Gly Cys Cys Thr Thr Thr Thr Cys Ala Gly Cys 
        195                 200                 205             


Gly Thr Cys Thr Gly Gly Thr Gly Cys Gly Thr Gly Ala Gly Ala Thr 
    210                 215                 220                 


Cys Gly Cys Gly Cys Ala Gly Gly Ala Cys Thr Thr Cys Ala Ala Gly 
225                 230                 235                 240 


Ala Cys Cys Gly Ala Cys Thr Thr Gly Cys Gly Cys Thr Thr Cys Cys 
                245                 250                 255     


Ala Gly Ala Gly Cys Thr Cys Cys Gly Cys Gly Gly Thr Gly Ala Thr 
            260                 265                 270         


Gly Gly Cys Gly Cys Thr Gly Cys Ala Ala Gly Ala Gly Gly Cys Ala 
        275                 280                 285             


Thr Gly Cys Gly Ala Gly Gly Cys Cys Thr Ala Cys Cys Thr Gly Gly 
    290                 295                 300                 


Thr Gly Gly Gly Gly Cys Thr Cys Thr Thr Thr Gly Ala Gly Gly Ala 
305                 310                 315                 320 


Cys Ala Cys Cys Ala Ala Cys Cys Thr Gly Thr Gly Cys Gly Cys Cys 
                325                 330                 335     


Ala Thr Cys Cys Ala Cys Gly Cys Cys Ala Ala Gly Cys Gly Gly Gly 
            340                 345                 350         


Thr Gly Ala Cys Thr Ala Thr Cys Ala Thr Gly Cys Cys Cys Ala Ala 
        355                 360                 365             


Gly Gly Ala Cys Ala Thr Cys Cys Ala Gly Cys Thr Cys Gly Cys Ala 
    370                 375                 380                 


Cys Gly Thr Cys Gly Thr Ala Thr Cys Cys Gly Cys Gly Gly Cys Gly 
385                 390                 395                 400 


Ala Gly Ala Gly Gly Gly Cys Thr Thr Gly Ala 
                405                 410     


<210>  51
<211>  136
<212>  PRT
<213>  Homo sapiens

<400>  51

Met Ala Arg Thr Lys Gln Thr Ala Arg Lys Ser Thr Gly Gly Lys Ala 
1               5                   10                  15      


Pro Arg Lys Gln Leu Ala Thr Lys Ala Ala Arg Lys Ser Ala Pro Ala 
            20                  25                  30          


Thr Gly Gly Val Lys Lys Pro His Arg Tyr Arg Pro Gly Thr Val Ala 
        35                  40                  45              


Leu Arg Glu Ile Arg Arg Tyr Gln Lys Ser Thr Glu Leu Leu Ile Arg 
    50                  55                  60                  


Lys Leu Pro Phe Gln Arg Leu Val Arg Glu Ile Ala Gln Asp Phe Lys 
65                  70                  75                  80  


Thr Asp Leu Arg Phe Gln Ser Ser Ala Val Met Ala Leu Gln Glu Ala 
                85                  90                  95      


Cys Glu Ala Tyr Leu Val Gly Leu Phe Glu Asp Thr Asn Leu Cys Ala 
            100                 105                 110         


Ile His Ala Lys Arg Val Thr Ile Met Pro Lys Asp Ile Gln Leu Ala 
        115                 120                 125             


Arg Arg Ile Arg Gly Glu Arg Ala 
    130                 135     


<210>  52
<211>  411
<212>  DNA
<213>  Homo sapiens

<400>  52
atggcacgaa caaagcaaac agctcgcaag tccaccggcg gcaaagcgcc gcgcaagcag       60

ctggccacca aggcggctcg caagagcgct ccggccaccg gtggcgtcaa gaagccccac      120

cgctaccgcc ccggcaccgt ggccctgcgc gagatccgcc gctaccagaa gtcgaccgag      180

ctgctaatcc ggaagctacc ttttcagcgc ttggtacggg agatcgcaca ggactttaag      240

accgatctgc gcttccagag ctcggcggtg atggcgctgc aggaggcttg cgaggcctac      300

ctggtggggc tatttgagga taccaacctg tgcgccattc acgccaaacg cgtcactatt      360

atgcctaaag acatccagct tgcgcgccgc atccgagggg agagggcata a               411


<210>  53
<211>  136
<212>  PRT
<213>  Homo sapiens

<400>  53

Met Ala Arg Thr Lys Gln Thr Ala Arg Lys Ser Thr Gly Gly Lys Ala 
1               5                   10                  15      


Pro Arg Lys Gln Leu Ala Thr Lys Ala Ala Arg Lys Ser Ala Pro Ala 
            20                  25                  30          


Thr Gly Gly Val Lys Lys Pro His Arg Tyr Arg Pro Gly Thr Val Ala 
        35                  40                  45              


Leu Arg Glu Ile Arg Arg Tyr Gln Lys Ser Thr Glu Leu Leu Ile Arg 
    50                  55                  60                  


Lys Leu Pro Phe Gln Arg Leu Val Arg Glu Ile Ala Gln Asp Phe Lys 
65                  70                  75                  80  


Thr Asp Leu Arg Phe Gln Ser Ser Ala Val Met Ala Leu Gln Glu Ala 
                85                  90                  95      


Cys Glu Ala Tyr Leu Val Gly Leu Phe Glu Asp Thr Asn Leu Cys Ala 
            100                 105                 110         


Ile His Ala Lys Arg Val Thr Ile Met Pro Lys Asp Ile Gln Leu Ala 
        115                 120                 125             


Arg Arg Ile Arg Gly Glu Arg Ala 
    130                 135     


<210>  54
<211>  411
<212>  DNA
<213>  Homo sapiens

<400>  54
atggcccgga cgaagcagac agctcgcaag tctaccggcg gcaaggcacc gcggaagcag       60

ctggccacca aggcagcgcg caaaagcgct ccagcgactg gcggtgtgaa gaagccccac      120

cgctacaggc caggcaccgt ggccttgcgt gagatccgcc gttatcagaa gtcgactgag      180

ctgctcatcc gcaaactgcc atttcagcgc ctggtgcgag aaatcgcgca ggatttcaaa      240

accgaccttc gtttccagag ctcggcggtg atggcgctgc aagaggcgtg cgaggcctat      300

ctggtgggtc tctttgaaga caccaacctc tgtgctattc acgccaagcg tgtcactatt      360

atgcctaagg acatccagct tgcgcgtcgt atccgtggcg agcgagcata a               411


<210>  55
<211>  136
<212>  PRT
<213>  Homo sapiens

<400>  55

Met Ala Arg Thr Lys Gln Thr Ala Arg Lys Ser Thr Gly Gly Lys Ala 
1               5                   10                  15      


Pro Arg Lys Gln Leu Ala Thr Lys Ala Ala Arg Lys Ser Ala Pro Ala 
            20                  25                  30          


Thr Gly Gly Val Lys Lys Pro His Arg Tyr Arg Pro Gly Thr Val Ala 
        35                  40                  45              


Leu Arg Glu Ile Arg Arg Tyr Gln Lys Ser Thr Glu Leu Leu Ile Arg 
    50                  55                  60                  


Lys Leu Pro Phe Gln Arg Leu Val Arg Glu Ile Ala Gln Asp Phe Lys 
65                  70                  75                  80  


Thr Asp Leu Arg Phe Gln Ser Ser Ala Val Met Ala Leu Gln Glu Ala 
                85                  90                  95      


Cys Glu Ala Tyr Leu Val Gly Leu Phe Glu Asp Thr Asn Leu Cys Ala 
            100                 105                 110         


Ile His Ala Lys Arg Val Thr Ile Met Pro Lys Asp Ile Gln Leu Ala 
        115                 120                 125             


Arg Arg Ile Arg Gly Glu Arg Ala 
    130                 135     


<210>  56
<211>  411
<212>  DNA
<213>  Homo sapiens

<400>  56
atggcccgta ctaagcagac tgctcgcaag tcgaccggcg gcaaggcccc gaggaagcag       60

ctggccacca aggcggcccg caagagcgcg ccggccacgg gcggggtgaa gaagccgcac      120

cgctaccggc ccggcaccgt agccctgcgg gagatccggc gctaccagaa gtccacggag      180

ctgctgatcc gcaagctgcc cttccagcgg ctggtacgcg agatcgcgca ggactttaag      240

acggacctgc gcttccagag ctcggccgtg atggcgctgc aggaggccag cgaggcctac      300

ctggtggggc tgttcgaaga cacgaacctg tgcgccatcc acgccaagcg cgtgaccatt      360

atgcccaagg acatccagct ggcccgccgc atccgtggag agcgggctta a               411


<210>  57
<211>  136
<212>  PRT
<213>  Homo sapiens

<400>  57

Met Ala Arg Thr Lys Gln Thr Ala Arg Lys Ser Thr Gly Gly Lys Ala 
1               5                   10                  15      


Pro Arg Lys Gln Leu Ala Thr Lys Ala Ala Arg Lys Ser Ala Pro Ala 
            20                  25                  30          


Thr Gly Gly Val Lys Lys Pro His Arg Tyr Arg Pro Gly Thr Val Ala 
        35                  40                  45              


Leu Arg Glu Ile Arg Arg Tyr Gln Lys Ser Thr Glu Leu Leu Ile Arg 
    50                  55                  60                  


Lys Leu Pro Phe Gln Arg Leu Val Arg Glu Ile Ala Gln Asp Phe Lys 
65                  70                  75                  80  


Thr Asp Leu Arg Phe Gln Ser Ser Ala Val Met Ala Leu Gln Glu Ala 
                85                  90                  95      


Ser Glu Ala Tyr Leu Val Gly Leu Phe Glu Asp Thr Asn Leu Cys Ala 
            100                 105                 110         


Ile His Ala Lys Arg Val Thr Ile Met Pro Lys Asp Ile Gln Leu Ala 
        115                 120                 125             


Arg Arg Ile Arg Gly Glu Arg Ala 
    130                 135     


<210>  58
<211>  411
<212>  DNA
<213>  Homo sapiens

<400>  58
atggcccgta ctaagcagac tgctcgcaag tcgaccggcg gcaaggcccc gaggaagcag       60

ctggccacca aggcggcccg caagagcgcg ccggccacgg gcggggtgaa gaagccgcac      120

cgctaccggc ccggcaccgt agccctgcgg gagatccggc gctaccagaa gtccacggag      180

ctgctgatcc gcaagctgcc cttccagcgg ctggtacgcg agatcgcgca ggactttaag      240

acggacctgc gcttccagag ctcggccgtg atggcgctgc aggaggccag cgaggcctac      300

ctggtggggc tgttcgaaga cacgaacctg tgcgccatcc acgccaagcg cgtgaccatt      360

atgcccaagg acatccagct ggcccgccgc atccgtggag agcgggctta a               411


<210>  59
<211>  136
<212>  PRT
<213>  Homo sapiens

<400>  59

Met Ala Arg Thr Lys Gln Thr Ala Arg Lys Ser Thr Gly Gly Lys Ala 
1               5                   10                  15      


Pro Arg Lys Gln Leu Ala Thr Lys Ala Ala Arg Lys Ser Ala Pro Ala 
            20                  25                  30          


Thr Gly Gly Val Lys Lys Pro His Arg Tyr Arg Pro Gly Thr Val Ala 
        35                  40                  45              


Leu Arg Glu Ile Arg Arg Tyr Gln Lys Ser Thr Glu Leu Leu Ile Arg 
    50                  55                  60                  


Lys Leu Pro Phe Gln Arg Leu Val Arg Glu Ile Ala Gln Asp Phe Lys 
65                  70                  75                  80  


Thr Asp Leu Arg Phe Gln Ser Ser Ala Val Met Ala Leu Gln Glu Ala 
                85                  90                  95      


Ser Glu Ala Tyr Leu Val Gly Leu Phe Glu Asp Thr Asn Leu Cys Ala 
            100                 105                 110         


Ile His Ala Lys Arg Val Thr Ile Met Pro Lys Asp Ile Gln Leu Ala 
        115                 120                 125             


Arg Arg Ile Arg Gly Glu Arg Ala 
    130                 135     


<210>  60
<211>  411
<212>  DNA
<213>  Homo sapiens

<400>  60
atggcccgta ctaagcagac tgcccgcaag tcgaccggcg gcaaggcccc gaggaagcag       60

ctggctacca aagcggcccg caagagcgcg ccggccacgg gcggggtgaa gaagccgcac      120

cgctaccggc ccggcaccgt ggctctgcgg gagatccggc gctaccagaa gtctacggag      180

ctgctgatcc gcaagctgcc cttccagcgg ctggtacgcg agatcgcgca ggactttaag      240

acggacctgc gcttccagag ctcggccgtg atggcgctgc aggaggccag cgaggcctac      300

ctggtggggc tgttcgaaga cacgaacctg tgcgccatcc atgccaagcg cgtgaccatc      360

atgcccaagg acatccagtt ggcccgccgc atccgcgggg agcgggccta a               411


<210>  61
<211>  136
<212>  PRT
<213>  Homo sapiens

<400>  61

Met Ala Arg Thr Lys Gln Thr Ala Arg Lys Ser Thr Gly Gly Lys Ala 
1               5                   10                  15      


Pro Arg Lys Gln Leu Ala Thr Lys Ala Ala Arg Lys Ser Ala Pro Ala 
            20                  25                  30          


Thr Gly Gly Val Lys Lys Pro His Arg Tyr Arg Pro Gly Thr Val Ala 
        35                  40                  45              


Leu Arg Glu Ile Arg Arg Tyr Gln Lys Ser Thr Glu Leu Leu Ile Arg 
    50                  55                  60                  


Lys Leu Pro Phe Gln Arg Leu Val Arg Glu Ile Ala Gln Asp Phe Lys 
65                  70                  75                  80  


Thr Asp Leu Arg Phe Gln Ser Ser Ala Val Met Ala Leu Gln Glu Ala 
                85                  90                  95      


Ser Glu Ala Tyr Leu Val Gly Leu Phe Glu Asp Thr Asn Leu Cys Ala 
            100                 105                 110         


Ile His Ala Lys Arg Val Thr Ile Met Pro Lys Asp Ile Gln Leu Ala 
        115                 120                 125             


Arg Arg Ile Arg Gly Glu Arg Ala 
    130                 135     


<210>  62
<211>  411
<212>  DNA
<213>  Homo sapiens

<400>  62
atggctcgta caaagcagac tgcccgcaaa tcgaccggtg gtaaagcacc caggaagcaa       60

ctggctacaa aagccgctcg caagagtgcg ccctctactg gaggggtgaa gaaacctcat      120

cgttacaggc ctggtactgt ggcgctccgt gaaattagac gttatcagaa gtccactgaa      180

cttctgattc gcaaacttcc cttccagcgt ctggtgcgag aaattgctca ggactttaaa      240

acagatctgc gcttccagag cgcagctatc ggtgctttgc aggaggcaag tgaggcctat      300

ctggttggcc tttttgaaga caccaacctg tgtgctatcc atgccaaacg tgtaacaatt      360

atgccaaaag acatccagct agcacgccgc atacgtggag aacgtgctta a               411


<210>  63
<211>  136
<212>  PRT
<213>  Homo sapiens

<400>  63

Met Ala Arg Thr Lys Gln Thr Ala Arg Lys Ser Thr Gly Gly Lys Ala 
1               5                   10                  15      


Pro Arg Lys Gln Leu Ala Thr Lys Ala Ala Arg Lys Ser Ala Pro Ser 
            20                  25                  30          


Thr Gly Gly Val Lys Lys Pro His Arg Tyr Arg Pro Gly Thr Val Ala 
        35                  40                  45              


Leu Arg Glu Ile Arg Arg Tyr Gln Lys Ser Thr Glu Leu Leu Ile Arg 
    50                  55                  60                  


Lys Leu Pro Phe Gln Arg Leu Val Arg Glu Ile Ala Gln Asp Phe Lys 
65                  70                  75                  80  


Thr Asp Leu Arg Phe Gln Ser Ala Ala Ile Gly Ala Leu Gln Glu Ala 
                85                  90                  95      


Ser Glu Ala Tyr Leu Val Gly Leu Phe Glu Asp Thr Asn Leu Cys Ala 
            100                 105                 110         


Ile His Ala Lys Arg Val Thr Ile Met Pro Lys Asp Ile Gln Leu Ala 
        115                 120                 125             


Arg Arg Ile Arg Gly Glu Arg Ala 
    130                 135     


<210>  64
<211>  411
<212>  DNA
<213>  Homo sapiens

<400>  64
atggcccgaa ccaagcagac tgctcgtaag tccaccggtg ggaaagcccc ccgcaaacag       60

ctggccacga aagccgccag gaaaagcgct ccctctaccg gcggggtgaa gaagcctcat      120

cgctacaggc ccgggaccgt ggcgcttcga gagattcgtc gttatcagaa gtcgaccgag      180

ctgctcatcc ggaagctgcc cttccagagg ttggtgaggg agatcgcgca ggatttcaaa      240

accgacctga ggtttcagag cgcagccatc ggtgcgctgc aggaggctag cgaagcgtac      300

ctggtgggtc tgttcgaaga taccaacctg tgtgccatcc acgctaagag agtcaccatc      360

atgcccaaag acatccagtt ggctcgccgg atacggggag agagagctta a               411


<210>  65
<211>  136
<212>  PRT
<213>  Homo sapiens

<400>  65

Met Ala Arg Thr Lys Gln Thr Ala Arg Lys Ser Thr Gly Gly Lys Ala 
1               5                   10                  15      


Pro Arg Lys Gln Leu Ala Thr Lys Ala Ala Arg Lys Ser Ala Pro Ser 
            20                  25                  30          


Thr Gly Gly Val Lys Lys Pro His Arg Tyr Arg Pro Gly Thr Val Ala 
        35                  40                  45              


Leu Arg Glu Ile Arg Arg Tyr Gln Lys Ser Thr Glu Leu Leu Ile Arg 
    50                  55                  60                  


Lys Leu Pro Phe Gln Arg Leu Val Arg Glu Ile Ala Gln Asp Phe Lys 
65                  70                  75                  80  


Thr Asp Leu Arg Phe Gln Ser Ala Ala Ile Gly Ala Leu Gln Glu Ala 
                85                  90                  95      


Ser Glu Ala Tyr Leu Val Gly Leu Phe Glu Asp Thr Asn Leu Cys Ala 
            100                 105                 110         


Ile His Ala Lys Arg Val Thr Ile Met Pro Lys Asp Ile Gln Leu Ala 
        115                 120                 125             


Arg Arg Ile Arg Gly Glu Arg Ala 
    130                 135     


<210>  66
<211>  1245
<212>  DNA
<213>  Homo sapiens

<400>  66
atgtccaaaa aaatcagtgg cggttctgtg gtagagatgc aaggagatga aatgacacga       60

atcatttggg aattgattaa agagaaactc atttttccct acgtggaatt ggatctacat      120

agctatgatt taggcataga gaatcgtgat gccaccaacg accaagtcac caaggatgct      180

gcagaagcta taaagaagca taatgttggc gtcaaatgtg ccactatcac tcctgatgag      240

aagagggttg aggagttcaa gttgaaacaa atgtggaaat caccaaatgg caccatacga      300

aatattctgg gtggcacggt cttcagagaa gccattatct gcaaaaatat cccccggctt      360

gtgagtggat gggtaaaacc tatcatcata ggtcgtcatg cttatgggga tcaatacaga      420

gcaactgatt ttgttgttcc tgggcctgga aaagtagaga taacctacac accaagtgac      480

ggaacccaaa aggtgacata cctggtacat aactttgaag aaggtggtgg tgttgccatg      540

gggatgtata atcaagataa gtcaattgaa gattttgcac acagttcctt ccaaatggct      600

ctgtctaagg gttggccttt gtatctgagc accaaaaaca ctattctgaa gaaatatgat      660

gggcgtttta aagacatctt tcaggagata tatgacaagc agtacaagtc ccagtttgaa      720

gctcaaaaga tctggtatga gcataggctc atcgacgaca tggtggccca agctatgaaa      780

tcagagggag gcttcatctg ggcctgtaaa aactatgatg gtgacgtgca gtcggactct      840

gtggcccaag ggtatggctc tctcggcatg atgaccagcg tgctggtttg tccagatggc      900

aagacagtag aagcagaggc tgcccacggg actgtaaccc gtcactaccg catgtaccag      960

aaaggacagg agacgtccac caatcccatt gcttccattt ttgcctggac cagagggtta     1020

gcccacagag caaagcttga taacaataaa gagcttgcct tctttgcaaa tgctttggaa     1080

gaagtctcta ttgagacaat tgaggctggc ttcatgacca aggacttggc tgcttgcatt     1140

aaaggtttac ccaatgtgca acgttctgac tacttgaata catttgagtt catggataaa     1200

cttggagaaa acttgaagat caaactagct caggccaaac tttaa                     1245


<210>  67
<211>  414
<212>  PRT
<213>  Homo sapiens

<400>  67

Met Ser Lys Lys Ile Ser Gly Gly Ser Val Val Glu Met Gln Gly Asp 
1               5                   10                  15      


Glu Met Thr Arg Ile Ile Trp Glu Leu Ile Lys Glu Lys Leu Ile Phe 
            20                  25                  30          


Pro Tyr Val Glu Leu Asp Leu His Ser Tyr Asp Leu Gly Ile Glu Asn 
        35                  40                  45              


Arg Asp Ala Thr Asn Asp Gln Val Thr Lys Asp Ala Ala Glu Ala Ile 
    50                  55                  60                  


Lys Lys His Asn Val Gly Val Lys Cys Ala Thr Ile Thr Pro Asp Glu 
65                  70                  75                  80  


Lys Arg Val Glu Glu Phe Lys Leu Lys Gln Met Trp Lys Ser Pro Asn 
                85                  90                  95      


Gly Thr Ile Arg Asn Ile Leu Gly Gly Thr Val Phe Arg Glu Ala Ile 
            100                 105                 110         


Ile Cys Lys Asn Ile Pro Arg Leu Val Ser Gly Trp Val Lys Pro Ile 
        115                 120                 125             


Ile Ile Gly Arg His Ala Tyr Gly Asp Gln Tyr Arg Ala Thr Asp Phe 
    130                 135                 140                 


Val Val Pro Gly Pro Gly Lys Val Glu Ile Thr Tyr Thr Pro Ser Asp 
145                 150                 155                 160 


Gly Thr Gln Lys Val Thr Tyr Leu Val His Asn Phe Glu Glu Gly Gly 
                165                 170                 175     


Gly Val Ala Met Gly Met Tyr Asn Gln Asp Lys Ser Ile Glu Asp Phe 
            180                 185                 190         


Ala His Ser Ser Phe Gln Met Ala Leu Ser Lys Gly Trp Pro Leu Tyr 
        195                 200                 205             


Leu Ser Thr Lys Asn Thr Ile Leu Lys Lys Tyr Asp Gly Arg Phe Lys 
    210                 215                 220                 


Asp Ile Phe Gln Glu Ile Tyr Asp Lys Gln Tyr Lys Ser Gln Phe Glu 
225                 230                 235                 240 


Ala Gln Lys Ile Trp Tyr Glu His Arg Leu Ile Asp Asp Met Val Ala 
                245                 250                 255     


Gln Ala Met Lys Ser Glu Gly Gly Phe Ile Trp Ala Cys Lys Asn Tyr 
            260                 265                 270         


Asp Gly Asp Val Gln Ser Asp Ser Val Ala Gln Gly Tyr Gly Ser Leu 
        275                 280                 285             


Gly Met Met Thr Ser Val Leu Val Cys Pro Asp Gly Lys Thr Val Glu 
    290                 295                 300                 


Ala Glu Ala Ala His Gly Thr Val Thr Arg His Tyr Arg Met Tyr Gln 
305                 310                 315                 320 


Lys Gly Gln Glu Thr Ser Thr Asn Pro Ile Ala Ser Ile Phe Ala Trp 
                325                 330                 335     


Thr Arg Gly Leu Ala His Arg Ala Lys Leu Asp Asn Asn Lys Glu Leu 
            340                 345                 350         


Ala Phe Phe Ala Asn Ala Leu Glu Glu Val Ser Ile Glu Thr Ile Glu 
        355                 360                 365             


Ala Gly Phe Met Thr Lys Asp Leu Ala Ala Cys Ile Lys Gly Leu Pro 
    370                 375                 380                 


Asn Val Gln Arg Ser Asp Tyr Leu Asn Thr Phe Glu Phe Met Asp Lys 
385                 390                 395                 400 


Leu Gly Glu Asn Leu Lys Ile Lys Leu Ala Gln Ala Lys Leu 
                405                 410                 


